| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.64070384 |
| We have identified c Myc as a binding partner for Bcr in both yeast and mammalian cells . 0.64070384^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| H ras and c myc RNA expression in human T cell ALL and in normal human lymphocytes . ^^^ We have compared the RNA expression of two oncogenes , H ras and c myc , with normal human lymphocytes , normal human T cells , and human T cell acute lymphoblastic leukemia ( ALL ) . ^^^ T cell ALL samples from four of five children overexpressed H ras , while three of five patient samples overexpressed the third exon of c myc when compared to normal lymphocytes and normal T cells . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Our studies revealed that this translocation and myc gene rearrangement can also be found in L 2 type B ALL . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| N myc was expressed in five of six AML cases studied , in one of nine acute lymphocytic leukemia ( ALL ) cases , and in several leukemia cell lines , while c myc mRNA was detected in all leukemias and leukemia cell lines studied . ^^^ Coexpression of all three myc genes was observed in Dami and MOLT 4 cell lines and in two AMLs , and either L myc or N myc was coexpressed with c myc in several other cases . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Varying amounts of c myc related RNA were found in RNAs from leukocytes from patients with ANLL , CGL and ALL . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| We have determined the prevalence of amplification and rearrangements for c myc , c myb , c mos , bcr , c abl , c Ha ras 1 , c N ras , and c K ras 2 in a total of 51 cases of human leukaemia ( 19 patients with AML , 13 cases with CML , 14 cases with ALL , and 5 cases with CLL ) . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The reciprocal chromosome translocation , t ( 8 ; 14 ) , involving the heavy chain locus on chromosome 14 and the c myc oncogene on chromosome 8 is a characteristic of the B cell malignancies Burkitt ' s lymphoma and acute lymphoblastic leukaemia ( ALL ) . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The DNA obtained from the leukemia cells of an acute lymphoblastic leukemia ( ALL , L 3 type ) with a pre B phenotype and a typical t ( 8 ; 14 ) chromosomal translocation showed a rearrangement juxtaposing the c myc gene and the immunoglobulin ( Ig ) heavy chain gene enhancer . ^^^ Finally , as previously suggested by others , the phenotype expressed by the leukemia cells supported the notion that this particular type of rearrangement ( linking together the c myc gene and the Ig heavy chain gene enhancer element ) may be associated with a subgroup of B ALLs showing an immunologic phenotype relatively more immature than that of classical B ALL . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Expression of c myc and c myb was detected in all leukemic cells at variable levels and was characterized by well defined patterns within ALL subtypes . ^^^ The structure of these protooncogenes was not grossly modified , as evaluated by Southern analysis , except for c myc rearrangement in B ALL . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Remarkably different levels of expression of c myc were observed in ALL , whereas in CLL the expression of c myc was uniformly low or absent . ^^^ Differential expression of c myc was detected in AML as well as in CML , c myb was differentially expressed in AML and ALL , and absent in CLL and CML . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| We report that p 53 inactivation in ALL of B cell lineage is restricted to cases carrying a rearrangement of MLL or c MYC , whereas it is consistently negative in other molecular subgroups . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Because of a possible synergy between c myc and bcl 2 proteins in cell lines , we compared 40 ALL of either T or B lineage with seven Burkitt ' s ALL or sporadic Burkitt ' s lymphomas ( BL ) . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| In all these cases IgH is juxtaposed to an oncogene ( c MYC , BCL 1 , and BCL 2 , respectively ) . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Although B ALL cells commonly have a characteristic chromosomal translocation that includes 8q24 ( the location of the c myc protooncogene ) , the leukemic cells of the two patients reported in this paper showed normal karyotypes . ^^^ A c myc probe was used , and no rearrangement or amplification of c myc expression was found ; B ALL with the translocation including 8q24 is reported to show high levels of expression of rearranged c myc . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Furthermore , overexpression of c myc mRNA was confirmed in ALL blasts . ^^^ These findings indicate that MDS transformed to Burkitt ' s ALL through multiple cytogenetic evolutions , the final event of which seems to be overexpression of the c myc gene . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| A close correlation between all these properties was demonstrated by the observations that the few CD 10 positive cells found in the CD 10 negative acute lymphoblastic leukaemia group displayed elevated c myc and cycling capacities and were apoptosis prone . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| We describe immunophenotype of : B lineage ALL with MLL rearrangements , TEL / AML1 , BCR / ABL , E2A / PBX1 translocations , hyperdiploidy , and myc fusion genes ; T ALL with SCL gene aberrations and t ( 5 ; 14 ) translocation ; and AML with AML1 / ETO , PML / RARalpha , OTT / MAL and CBFbeta / MYH11 translocations , trisomies 8 or 11 and aberrations of chromosomes 7 and 5 . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The pattern of c myc rearrangement of the tonsil demonstrated by southern blotting was identical to that of the bone marrow at initial presentation and the recurrence of primary ALL L3 / BL was thus confirmed . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Finally , the transactivation and transrepression ( via NF kappa B and AP 1 binding ) of a wide range of genes ( like c myc ) which initiates the final apoptosis pathway are discussed and suggestions for future directions of research in ALL patients are given . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The expression of apoptosis related genes BCL 2 , BAX , BCL2L1 , BCL2A1 , MCL 1 , DAPK 1 and MYC was studied by quantitative real time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia ( ALL , n = 16 ) , acute myeloid leukaemia ( AML , n = 27 ) , chronic myeloid leukaemia ( CML , n = 12 ) , mantle cell lymphoma ( MCL , n = 19 ) and chronic lymphoid leukaemia ( CLL , n = 32 ) . ^^^ BCL 2 , BAX , BCL2A1 , MCL 1 , DAPK 1 and MYC were overexpressed in all patient groups . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Interestingly , multiple genes linked to cell proliferation ( eg , PCNA , MYC , CDK 2 , and POLA ) were down regulated in MLL fusion samples , relative to those transformed by other T ALL oncogenes ( P < . 000 001 , Fisher exact test ) . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The occurrence of a third oncogene rearrangement in association with the dual BCL 2 , cMYC translocations in ALL patients is very rare . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : B lineage ALL with a mature phenotype , L 1 morphology , and absent chromosomal translocations involving the c myc gene is best classified and managed as precursor B lymphoblastic leukemia / lymphoma instead of Burkitt leukemia / lymphoma . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| GC induced cell cycle arrest in ALL cells appears to be independent of apoptosis induction and vice versa , and critically depends on repression of both cyclin D 3 and c myc followed by increased expression of the cyclin dependent kinase inhibitor , p27Kip1 . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Mature B cell acute lymphoblastic leukemia ( ALL ) is typically associated with the FAB L 3 morphology and rearrangement of the MYC gene , features characteristic of the leukemic phase of Burkitt ' s lymphoma . ^^^ We describe two unusual cases of infantile B ALL with non L 3 morphology , expressing a mature B cell phenotype ( lambda sIg+ , CD19+ , CD 10 , TdT , and CD 34 ) , and showing MLL rearrangement without MYC rearrangement at presentation . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| CMYC translocations were absent in Burkitt like lymphomas from all three patients . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| G banding analysis , fluorescence in situ hybridization ( FISH ) with the IGH ( Cgamma and VH ) and oncogene ( c MYC , BCL 1 , BCL 2 , and BCL 6 ) probes , and long distance polymerase chain reaction ( LD PCR ) were performed on 6 patients with B cell lymphoma , one with angioimmunoblastic T cell lymphoma , and one with acute lymphoblastic leukemia ( ALL ) with B cell phenotype . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Thus , ectopic p185 / p190 BCR ABL expression , such as p 210 BCR ABL , PML RARA , or C MYC transduction , may induce an increased chromosomal instability leading to clonal karyotypic evolution , which may mimic secondary chromosome aberrations in human Ph positive ALL . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| We examined whether aberrant protein stabilization could be a mechanism of c Myc overexpression in leukemia cell lines and in primary bone marrow samples from pediatric acute lymphoblastic leukemia ( ALL ) patients . ^^^ Moreover , stabilized c Myc from the ALL cell lines showed decreased affinity for glycogen synthase kinase3beta , the kinase that phosphorylates c Myc at Threonine 58 and facilitates its degradation . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| No rearrangements could be demonstrated within or near the genes c myc , c myb , c abl , bcr , c Ki ras , and N ras . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The study of these events led to the identification of the key genes involved ( BCR , ABL , C MYC , RB 1 and N MYC ) and served as models for substantial further work . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| These results help to explain the ability of BCR ABL oncogenes to synergize with c myc in cell transformation . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| One of these genes , c myc , appears to play an important role in mediating apoptosis in B cells stimulated via the BCR complex . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Neither Ph chromosome , nor cabl and bcr gen rearrangement were demonstrated , but the expression and amplification of c myc oncogene indicated disease progression . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Differential complementation of Bcr Abl point mutants with c Myc . ^^^ Transformation inactive point mutants of Bcr Abl were tested for complementation with c Myc . ^^^ Hyperexpression of c Myc efficiently restored transformation activity only to the Bcr Abl SH 2 mutant . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The nuclear oncogene c myc plays a critical role in BCR ABL transformation . ^^^ Levels of c myc RNA are high in cells transformed by BCR ABL , and overexpression of dominant negative forms of myc blocks transformation by BCR ABL . ^^^ The role of myc in transformation by BCR ABL . ^^^ These findings suggest that myc may be a useful therapeutic target in BCR ABL related leukemias . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Expression of an exogenous myc gene in fibroblasts partially complements the transforming capacity of mutant P 210 BCR / ABL ( 1294F ) . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Nonetheless , the loss of the negative cell growth regulation by c ABL , or BCR / ABL fusion protein interaction with other cellular genes ( such as RAS or c MYC ) could also be involved in CML pathophysiology . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , the upstream regulatory element of the c myc promoter , known to be regulated by NF kappaB , was differently regulated after BCR ligation vs BCR plus CD 40 crosslinking . ^^^ The level of c myc RNA was rapidly downregulated after BCR engagement , but persistent in the presence of CD 40 signaling . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the B cell Ag receptor ( BCR ) induces activation of tyrosine kinases such as Lyn and Syk , phosphorylation and activation of multiple signaling components , and eventually , the expression of several genes including c myc . ^^^ Here , we report that BCR mediated induction of c myc promoter activity and of PKC activity , but not the expression level of functional PKC , was markedly augmented in Lyn deficient chicken B cells . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| In B lymphoma line WEHI 231 , stable expression of c Myc has been demonstrated to protect cells from BCR mediated apoptosis . ^^^ When transactivation of p 53 was inactivated , WEHI 231 cells overexpressing c Myc no longer underwent apoptosis in the absence of other stimuli , but showed markedly enhanced apoptosis in the presence of BCR ligation . ^^^ These results indicate that deregulated c Myc expression enhances apoptosis by a p 53 independent pathway in the presence of BCR signaling but requires p 53 for apoptosis in the absence of BCR crosslinking in WEHI 231 . ^^^ BCR ligation may thus activate a p 53 independent pathway of c Myc induced apoptosis . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The susceptibility of activated memory B cells to BCR induced killing is correlated with their enhanced expression of the transcripts encoding the pro apoptotic molecules Bax , c Myc and p 53 . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The influence of the cell cycle , differentiation and irradiation on the nuclear location of the abl , bcr and c myc genes in human leukemic cells . abl and bcr genes play an important role in the diagnostics of chronic myelogenous leukemia ( CML ) . ^^^ Nuclear topology of the abl , bcr and c myc genes was determined in differentiated as well as in irradiated HL 60 cells using dual colour fluorescence in situ hybridisation and image analysis by means of a high resolution cytometer . ^^^ We suggest that changes in the abl , bcr and c myc topology in the case of gamma irradiation are not the effects of the cell cycle . ^^^ It is possible , that differences in the cell cycle of hematopoietic cells after the gamma irradiation and concurrent proximity of the abl , bcr and c myc genes could be important from the point of view of contingent gene translocations , that are responsible for malignant transformation of cells . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| B cell receptor ( BCR ) cross linking with antibodies to membrane IgM ( but not with anti IgD ) induces c Myc downregulation via nuclear factor kappaB inactivation and p 27 ( Kip 1 ) accumulation in these B lymphomas . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Here we show that overexpression of BRDG 1 strongly augments BCR mediated activation of cAMP response element binding protein ( CREB ) but not that of c Jun and the promoters of c MYC and BCL xL genes . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Although signaling pathways for apoptosis are not yet fully defined in BCR mediated apoptosis , expression of the proto oncogene product c Myc is enhanced upon BCR ligation , and c Myc appears to mediate BCR ligation induced apoptosis by causing mitochondrial dysfunction , suggesting that BCR mediated apoptosis is a form of Myc induced apoptosis . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Downregulated genes at both time points were : IL2RA , CMYC , NPM , DEK , AF 4 , FLI 1 , htlf , MNDA , BCR , IKAROS , BPI and NFAT 4 . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The present studies demonstrate that BCR ligation of WEHI 231 as well as of normal immature B cells greatly increased expression of CTCF in association with down regulation of MYC followed by growth arrest and cell death . ^^^ Conditional expression of CTCF in WEHI 231 mimicked BCR ligation with activated cells showing repressed expression of MYC , enhanced expression of p 27 , p 21 , p 53 , and p 19 ( ARF ) , and inhibition of cell growth and induction of apoptosis . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Nevertheless , rapid down regulation of c Myc following BCR engagement seems to correlate with the resistance of B cells to apoptosis . ^^^ Thus , the soluble form of Lyn generated by caspases following BCR triggering acts as an inhibitor of B lymphocyte death likely through the modulation of c Myc expression . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| In this study , we assessed whether differential c Myc responsiveness to B cell receptor ( BCR ) ligation is associated with the mechanism of negative selection in immature B cells . ^^^ Using an in vitro bone marrow culture system and an Ig transgenic mouse model ( 3 83 ) we show here that c Myc is expressed at low levels throughout B cell development and that c Myc responsiveness to BCR ligation is developmentally regulated and increased with maturation . ^^^ Furthermore , we found that the competence to mount c Myc responsiveness upon BCR ligation is important for the induction of apoptosis and had no effect on the process of receptor editing . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Upon engagement of the B Cell Receptor ( BCR ) of WEHI 231 immature B cells , a drop in c Myc expression is followed by activation of the cyclin dependent kinase inhibitor ( CKI ) p 27 ( Kip 1 ) , which induces growth arrest and apoptosis . ^^^ Here , we report inverse patterns of p 27 and c Myc protein expression follow BCR engagement . ^^^ Induction of p 27 promoter activity followed BCR engagement of WEHI 231 cells , and this induction could be repressed upon co transfection of a c Myc expression vector . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Domains in BCR and ABL sequences work in concert to elicit a variety of leukemogenic signals including Ras , STAT 5 ( signal transducer and activator of transcription 5 ) , Myc , cyclin D 1 , P 13 ( phosphatidylinositol 3 kinase ) , RIN 1 ( Ras interaction / interference ) , and activation of actin cytoskeleton . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| To study the regulation of expression of the myc protooncogene , cells from normal individuals and patients with acute myelogenous leukemia ( AML ) , and chronic phase and blastic crisis of chronic myeloid leukemia ( CML ) cells were put in overnight culture in the presence or absence of fetal calf serum . ^^^ Myc expression in normal marrow cells and chronic phase CML cells fell after culture in vitro . ^^^ In contrast , myc expression was maintained or increased in a majority of the AML and blastic crisis CML specimens . ^^^ These data demonstrate that the regulation of myc expression is disordered in many AML and blastic crisis specimens but not in chronic phase CML cells . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The expression of C myc proto oncogene were studied at the levels of protein in bone marrow cells obtained from patients with AML and CML . ^^^ It was found that the expression of C myc in florid AML and during blast phase of CML were much higher than that in remission of AML and in chronic phase of CML . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Diagnosis and / or prognosis related alterations of ( proto ) oncogenes may be detected in neuroblastoma ( N myc ) , carcinoma of breast and ovary ( HER2 / neu ) , NHL ( c myc , bcl 2 ) , CML ( c abl / bcr ) , and some other neoplasias . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| While the c myc RNA level in the CML cell population as a whole is similar to that in normal marrow cell populations and less than that in the bone marrow cells of patients with acute myelogenous leukemia ( AML ) , c myc RNA levels in subpopulations of immature chronic phase CML myeloid cells approximate that found in AML cells . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The changes of mRNAs of both c myc and MDR 1 in CML bc tumor cells during the clinical course : a case report ] . ^^^ We examined the expressions of both c myc and MDR 1 in four samples isolated from a CML bc patient in series during the clinical course . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| A wide range of signal transduction molecules are activated by BCR / ABL1 , including MYC , PI 3 kinase , and different STAT molecules . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Bcr can form a complex with beta catenin and negatively regulate expression of c Myc . ^^^ Knockdown of Bcr by short interfering RNA relieves the block and activates expression of c Myc . ^^^ Expression of Bcr in the human colon carcinoma cell line HCT 116 , which has a high level of endogenous beta catenin , leads to reduced c Myc expression . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Outside the GC , AID ( + ) B cells are in contact with T cells and show partial evidence of CD 40 plus bcr stimulation dependent signature ( CCL 22 , JunB , cMYC , CD 30 ) but lack early and late plasma cell markers . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Two notable examples are that of the t ( 9 ; 22 ) translocation of chronic myelogenous leukemia ( CML ) , causing the transfer of the oncogene c abl from chromosome 9 to chromosome 22 , and that of the t ( 8 ; 14 ) translocation of Burkitt lymphoma , causing the transfer of the oncogene c myc from chromosome 8 to chromosome 14 . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Therefore , we examined the effect of c Myc protein downregulation , using antisense oligodeoxynucleotides , on the growth of the BCR / ABL dependent cell line and chronic myelogenous leukemia ( CML ) patients cells . ^^^ Downregulation of c Myc expression caused complete inhibition of the proliferation of BCR / ABL dependent BV 173 cell line and 50 70 % inhibition of the colony formation of CML cells . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| In regard to specific genetic aberrations , sporadic reports have shown alterations in H RAS , c MYC , retinoblastoma , and P 53 genes , as well as production of p190BCR ABL during the progression of CML . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Moreover , colony formation by the primary CML cells was also inhibited 75 95 % and up to 99 % by anti c myc and anti bcr abl phosphoramidate oligonucleotides , respectively , in a sequence and dose dependent manner within a 0 . 5 nM 5 microM dose range . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Detection of c myc oncogene amplification in a CML blastic phase patient with double minute chromosomes . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The expression of c abl , c sis , c myc and N ras oncogenes was examined in 2 lymphoblastoid cell lines , one with Ph 1 ( PB 1049 ) and the other without Ph 1 ( LN 1049 ) , both established from a patient with chronic myelogenous leukemia ( CML ) , and in a Ph 1 positive cell line ( PB 1049 T ) derived from a tumor formed after transplantation of PB 1049 cells in a nude mouse with reference to their tumorigenic potential in nude mice . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The expression of the proto oncogene c myc was studied at the protein level in cells obtained from patients with AML and CML . ^^^ In florid AML and during the blastic phase of CML the majority of cells contain c myc protein with the amount of protein differing widely among the cells of individual patients . ^^^ In contrast , during complete remission in AML and during the chronic phase of CML cells containing c myc protein are rare . ^^^ Further , the data suggest that high levels of c myc protein in the leukemic cells of AML patients are associated with a poor response to therapy and that high levels in AML patients in CR or in the peripheral blood of chronic phase CML patients may be indicative of impending acute leukemia . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The blast crisis of CML has been variably associated with abnormalities of proto oncogenes , such as RAS and MYC , or of tumour suppressor genes , in particular RB , p 53 and p 16 , or with the generation of chimeric transcription factors , as in the AML 1 EVI1 gene fusion . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The proliferation of chronic myelogenous leukemia ( CML ) cells and the transformation of normal hematopoietic cells by BCR ABL appear to require the expression of a functional MYC protein , suggesting an approach to treatment of Philadelphia leukemias based on simultaneous targeting of BCR ABL and c MYC . ^^^ To test this hypothesis , CML blast crisis ( CML BC ) primary cells were treated in vitro with bcr abl and c myc antisense phosphorothioate oligodeoxynucleotides ( [ S ] ODNs ) , individually or in combination . ^^^ To assess the therapeutic potential of multiple oncogene downregulation , SCID mice injected with CML BC primary cells were treated systematically with equal doses of bcr abl or c myc antisense [ S ] ODNs or with a combination of both antisense [ S ] ODNs . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| In conclusion , the characteristics of CML cells , namely proliferation rate , c myc and bcl 2 change during the course of the disease . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| During the course of a study aimed at improving antisense oligodeoxynucleotide mediated ex vivo bone marrow purging of patients suffering from chronic myeloid leukemia ( CML ) , the properties of a number of antisense structures intended to reduce the expression of c myc , mutant p 53 , and bcr abl mRNAs and proteins were examined . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| To date , molecular genetic studies of CML BC have mainly focused on alterations of well known tumor suppressor genes ( e . g . , TP 53 , CDKN2A , and RB 1 ) and oncogenes ( e . g . , RAS and MYC ) , whereas limited knowledge is available about the molecular genetic correlates of the unbalanced chromosomal abnormalities . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the effects of interferon alpha ( IFN alpha ) and IFN alpha combined with granulocytic macrophage colony stimulating factor ( GM CSF ) on expression of bcr abl , bcl 2 and c myc genes in the mononuclear cells ( MNCs ) from bone marrow ( BM ) of the patients with chronic myelogenous leukemia at chronic phase ( CML CP ) . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The discovery that some of these genes were located at the breakpoints of chromosome rearrangements in human malignancies , such as the MYC gene in Burkitt ' s lymphoma and the ABL gene in chronic myeloid leukemia ( CML ) has suggested that chromosome abnormalities were causally implicated in the pathogenesis of human diseases . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Enhanced apoptosis by the co treatment was abrogated by ectopic expression of cyclin D 1 , c Myc or active MEK CONCLUSION : The combination of FK 228 with STI 571 is a promising treatment for Bcr Abl positive CML , but the activation of the MEK / ERK pathway and its downstream target genes may bring resistance to the co treatment in leukemic cells . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Because c Myc and Ras cooperate in cell transformation and c Myc is up regulated in CML , we investigated the effect of c Myc on Ras activity in K 562 cells . c Myc antagonized the induction of p21Cip1 mediated by oncogenic H , K , and N Ras and by constitutively activated Raf and ERK 2 . ^^^ The data suggest that in particular tumor types , such as those associated with CML , c Myc contributes to tumorigenesis by inhibiting Ras antiproliferative activity . . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The aim of our study was to carry out the analysis of the presence of the amplification of the c myc oncogene , as well as the analysis of the changes in the expression of Bcl 2 in the patients with CML . ^^^ |
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| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| A novel MLH 1 mutation harbored as a germ line aberration by a young woman of an HNPCC like family and exhibited by a CML patient when occurring prior to the initiation of the blast phase concomitant with a c MYC amplification . ^^^ We further revealed a concomitant c MYC dramatic amplification in the CML MLH 1 mutation carrier patient , also occurring at the pre blast phase . ^^^ Furthermore , given the role of c MYC and its interaction with MLH 1 , taken together with the mutational status of both genes revealed at the pre blast phase in the CML patient , a plausible increased genetic instability might be expected to take place , possibly contributing to blast triggering . ^^^ |
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| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Treatment of CML cell lines and mouse Bcr Abl+ 32D cells with either Jak 2 short interfering RNA or Jak 2 kinase inhibitor AG 490 inhibited pTyr Gab 2 and pSer Akt formation , inhibited the activation of nuclear factor kappaB , and caused the activation of GSK 3beta , leading to the reduction of c Myc . ^^^ |
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| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| The mitochondrial cDNA sequences included cytochrome c oxidase , Wnt 13 , and the pHL gene , a c myc oncogene containing coxIII sequence . ^^^ |
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| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| Accordingly , MYC protein but not mRNA levels are increased in the CD34+ fraction of patients with CML in accelerated and blastic phase but not in chronic phase CML patients and in the CD34+ fraction of marrow cells from healthy donors . ^^^ |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11274 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|