Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
These experiments demonstrated that the mutant RB product is capable of binding in vitro to c myc and L myc proteins with comparable affinity as wild type RB . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Alterations of oncogenes such as K ras , c erbB 2 / HER 2 / neu and c myc , and those of tumor suppressor genes such as p 53 , RB and DCC have been reported in ovarian cancer . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In addition , we studied the c myc gene for rearrangements by Southern blotting and assessed expression of the retinoblastoma ( Rb ) and p 53 genes by immunostaining . ^^^ Thus , mutations in the p 53 locus may be a cofactor for the development of ATLL in some cases , whereas the c myc , Rb , and RAS genes do not appear to be involved in these neoplasms . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Three nuclear genes , c myc , RB , and cyclin A were found to be common key downstream targets along the cytokine induced growth suppressive pathways . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Transcriptional repression of the E 2 containing promoters EIIaE , c myc , and RB 1 by the product of the RB 1 gene . ^^^ We now show that overexpression of p110RB1 causes repression of the adenovirus early promoter EIIaE and the promoters of two cellular genes , c myc and RB 1 , both of which contain E2F binding motifs . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Similar sequences are found in the promoters of two additional genes that are regulated by Rb ( c myc and TGF beta 1 ) , and binding assays demonstrate that the RCPs also interact with these elements . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The drug induced up or down regulation of RB expression did not correlate with changes in c myc expression indicating that the changes are not a manifestation of general metabolic changes potentially associated with altered proliferation . ^^^ Amongst the agents considered , retinoic acid was the only one that caused a significant parallel reduction in RB and c myc expression in the HL 60 human promyelocytic leukemia cells tested . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Vanadate did not increase mRNA corresponding to c src , c mos , c myc , p 53 , HSP 70 , pODC or RB genes , and expression of c erb A , c erb B , c sis and c fes genes was undetectable whether vanadium was present or not . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Abrogation by c myc of G 1 phase arrest induced by RB protein but not by p 53 . ^^^ The c myc protein is localized in the nucleus and can physically associate with RB protein in vitro , hence c myc may functionally antagonize RB function . ^^^ Here we co inject RB protein with c myc , EJ ras , c fos or c jun protein . ^^^ Co injection of c myc , but not EJ ras , c fos or c jun , inhibits the ability of Rb to arrest the cell cycle . ^^^ Thus , c myc and RB specifically antagonize one another in the cell . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Complex characteristics of the alterations of oncogenes HER 2 / ERBB 2 , HER 1 / ERBB 1 , HRAS 1 , C MYC and antioncogenes p 53 , RB 1 , as well as deletions of loci of chromosome 17 in colon carcinoma ] . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Southern blot hybridization was used to detect the rearrangement and amplification of five proto oncogenes ( bcl 2 , bcl 1 , c myc , c myb and c Ha ras ) and one tumor suppressor gene ( RB 1 ) in 55 Japanese patients with non Hodgkin ' s lymphoma ; 16 with T cell lymphomas and 39 with B cell lymphomas ( 7 follicular and 32 diffuse lymphomas ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Coupled down regulation of the RB retinoblastoma and c myc genes antecedes cell differentiation : possible role of RB as a `` status quo ' ' gene . ^^^ To investigate the potential coupling between down regulation of RB and c myc oncogene expression with cell differentiation , dose response relationships for the induced down regulation of RB and c myc expression were compared with each other and with induced cell differentiation . ^^^ In dose response experiments , progressively increasing RA or VD concentrations caused progressively greater reductions in RB as well as c myc expression with an increasing fraction of cells terminally differentiating . ^^^ For both RA and VD , the dose response relationships for reductions in RB and c myc expression were similar suggesting that their down regulation may be coupled . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Thus , taken with previous results , then amongst the nuclear oncogenes or tumor suppressor genes , c myc , RB , c fos , and c myb , only c myc and RB expression exhibit early regulation during induced HL 60 cell differentiation . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Twenty five mouse lung tumors induced by a single urethan treatment in female A / J , BALB / c , and ( A / J 10 C3H / He ) F 1 ( AC 3 ) mice were analyzed for the presence of mutations at codon 61 of the Ki ras gene and for the expression of the surfactant protein A ( SP A ) , retinoblastoma ( Rb ) , growth arrest specific 3 ( gas 3 ) , p 53 , c myc , and thymidylate synthase ( TS ) genes . ^^^ Our data suggest that the pathogenesis of urethan induced lung tumors in mice involves specific and recurrent molecular alterations ( Ki ras mutations , decrease of Rb and gas 3 expression , and increase of c myc expression ) that could represent different steps in lung carcinogenesis . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Two copies of a motif ( the retinoblastoma control element ) similar to that found in the human c fos , transforming growth factor beta 1 , and c myc promoters are responsible for conferring Rb regulation to the fourth promoter of the insulinlike growth factor 2 gene . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In addition , the same DNAs have been analysed for abnormalities in the c myc , p 53 and retinoblastoma ( Rb 1 ) gene loci by Southern blotting . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The expression of the protein products of the c myc oncogene and retinoblastoma susceptibility gene ( RB ) was investigated during either goat anti mouse immunoglobulin ( GaMIg ) or phorbol ester ( TPA ) induced growth arrest of the murine B lymphoma cell line WEHI 231 . ^^^ Thus post translational control of both c myc and RB expression occurs during the growth arrest of WEHI 231 cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In addition , the mouse tumor was analysed for structural and expression changes in the Rb and the c myc genes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Recent evidence suggests that the inhibitory effects of TGF beta on growth , at least , might be mediated through the RB tumour suppressor gene product and the proto oncogene c myc . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Furthermore , a mutant Rb protein from a human tumour cell line that carried a 35 amino acid deletion in its C terminus failed to bind to c myc . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
TGF beta 1 , which rapidly elevates the steady state level of junB and PAI 1 mRNAs and decreases that of c myc mRNA , induces these responses in S phase populations of Mv1Lu lung epithelial cells containing RB in a phosphorylated state . ^^^ These results suggests that the c myc , junB , and PAI 1 responses to TGF beta 1 are not restricted to the G 1 phase of the cell cycle and that down regulation of c myc expression by TGF beta 1 can occur through a mechanism independent from the growth suppressive function of RB . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Forty four B chronic lymphocytic leukemias ( CLL ) were studied by Southern blot analysis using probes for the Ig genes and bcl 1 , bcl 2 ( major , minor and 5 ' breakpoint region ) , bcl 3 , c myc , and retinoblastoma ( Rb ) loci . ^^^ No rearrangements were detected of c myc and bcl 3 , located at chromosome 19 , nor was a deletion of Rb found . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Five oncogenes have been implied as having a role in human breast tumorigenesis : int 2 , c erbB 2 ( HER 2 ) , c myc , c Ha ras and the recessive Rb 1 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The results suggest the importance of the c myc oncogene in the growth and morphological control of human osteosarcoma cells and of the Rb gene in the pathogenesis of the tumor . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The study of these events led to the identification of the key genes involved ( BCR , ABL , C MYC , RB 1 and N MYC ) and served as models for substantial further work . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The experiments reported herein were designed to examine the effects of either JANUS neutron or gamma ray exposure on expression of genes encoding nucleus associated proteins ( H 4 histone , c jun , c myc , Rb , and p 53 ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We performed experiments to determine the effects of ionizing radiation exposure on expression of genes such as beta actin , c fos , histone H 4 , c myc , c jun , Rb , and p 53 after exposure of Syrian hamster embryo ( SHE ) cells to the protein synthesis inhibitor cycloheximide . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The results of slot blot hybridizations showed that tumor promoter TPA induced c fos and c myc expressions in mouse fibroblast cell line BALB / 3T3 and rat liver , decreased the levels of Rb RNA in BALB / 3T3 cell line and of alpha 1 I 3 RNA in rat liver . ^^^ Tumor promoters induced the expressions of c fos and c myc which were positively related to cancer formation and inhibited the expressions of Rb and alpha 1 I 3 which were negatively related to cancer formation . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
This study examined the effect of transforming growth factor beta 1 ( TGF beta 1 ) on c myc , RB 1 , junB and p 53 expression together with pRb phosphorylation , in carcinoma derived and normal human oral keratinocytes with a range of inhibitory responses to this ligand . ^^^ The data indicate that TGF beta induced growth control can exist independently of the presence of mutant p 53 and the control of Rb phosphorylation and c myc down regulation . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Together , these data demonstrate that relatively undifferentiated osteosarcomas commonly display c myc amplification , p 53 and RB 1 mutation , and autocrine growth factor production , all of which may play a role in osteosarcomagenesis . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
HB 1 cells showed chronic , high expression of c myc and Ha ras oncogenes but no N myc and apparently normal RB gene expression . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
RB gene alterations were found to occur more frequently in estrogen receptor ( ER ) positive than in ER negative tumours and less frequently in tumours with oncogene amplification than in tumours without oncogene amplification of HER2 / neu , c myc or 11q13 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We have investigated levels of mRNA encoding cdk 1 ( p34cdc2 ) , cyclin A , cyclin B , Rb , GAPDH , c myc , and histone H 4 genes for sensitivity to okadaic acid in HeLa cells to determine if transformation altered their regulation . ^^^ When starved cells were subsequently exposed to 19 nM okadaic acid or refed 10 % serum , mRNA levels of cyclin A , cyclin B , cdk 1 , and Rb dramatically increased while mRNA levels for c myc and GAPDH were largely unaffected . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Cells en route to apoptosis are characterized by the upregulation of c fos , c myc , c jun , cdc 2 , and RB phosphorylation , resembling events of early cell cycle traverse . ^^^ Investigating the regulation of early cell cycle genes during this process , we found that c myc , c jun , c fos , and cdc 2 protein presence is induced after serum deprivation , when the phosphorylated form of the RB protein also appears . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Essentially the same region of the c Myc protein also binds the product of the retinoblastoma gene , the RB protein . c Myc protein coimmunoprecipitates with TBP in lysates of mammalian cells , demonstrating that the proteins are also complexed in vivo . ^^^ A short peptide that spans the RB binding site of the E 7 protein of human papilloma virus type 16 interferes with the binding of c Myc to TBP . ^^^ The same peptide also blocks binding of adenovirus E1A protein to TBP , suggesting that c Myc and E1A bind to RB and TBP through overlapping epitopes . ^^^ Our data suggest that one of the functions of RB and RB like proteins is to prevent interaction of viral and cellular oncoproteins , such as c Myc and E1A , with TBP . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The percentage of myeloma patients with a greater than normal incidence of plasma cells expressing these proteins was 53 % for c myc , 28 % for Rb , 28 % for bcl 2 , 27 % for c fos , 24 % for p 53 wild , 22 % for p 53 mutant , 13 % for c neu and 13 % for pan ras . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Expression of tumour suppressor gene Rb , apoptosis suppressing protein Bcl 2 and c Myc have no independent prognostic value in renal adenocarcinoma . ^^^ The expression of retinoblastoma ( Rb ) , c Myc and Bcl 2 proteins was studied by immunohistochemical methods in 104 cases of renal adenocarcinoma . ^^^ In multivariate analysis the expression of Rb , Bcl 2 and c Myc had no independent prognostic value over T category ( P < 0 . 001 ) , mitotic index ( P = 0 . 008 ) and combined nuclear grade ( P = 0 . 056 ) . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The transient expression of the retinoblastoma protein ( Rb ) regulates the transcription of a variety of growth control genes , including c fos , c myc , and the gene for transforming growth factor beta 1 via discrete promoter sequences termed retinoblastoma control elements ( RCE ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The protein product of the retinoblastoma tumor suppressor gene ( RB ) has been demonstrated to bind c Myc protein ( Myc ) in vitro . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The levels of most proteins ( including 5 Rel , p 53 , c Myc , Rb and Bcl 2 ) do not change in these cells even at advanced stages of apoptosis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The simian virus 40 large T antigen ( LT ) shares structural and functional homology with E1a and c myc , and all three proteins bind to the retinoblastoma gene product , Rb . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
DNA copy number abnormalities detected in this study include previously identified increases at 1p22 32 ( L myc ) , 2p24 25 ( N myc ) , and 8q24 ( c myc ) and decreases at 17p13 ( p 53 ) , 13q14 ( RB ) , and 3p . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Proliferation and differentiation of villous trophoblast during placental development , from an early stage to full term , were investigated in routinely fixed and processed tissues , by means of the immunocytochemical localization of the cell cycle related proto oncogene c myc and the p 53 and retinoblastoma susceptibility ( Rb ) tumour suppressor gene products . ^^^ Diffuse nuclear immunoreactivity for PCNA , c myc and Rb gene products was a consistent finding in early cytotrophoblast ; c myc product expression was also detectable in both layers of mid gestation trophoblast . ^^^ In full term placenta c myc expression was undetectable while Rb gene product and PCNA immunoreactivity declined markedly . ^^^ A potential involvement of the oncosuppressor gene products p 53 and Rb in the control of trophoblastic proliferation and of c myc in the control of both the proliferative and differentiation pathways of trophoblastic cells is suggested . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
BON cells also exhibited increased expression of c myc and cdc 2 kinase mRNA and protein ; TGF beta 1 , p 53 and retinoblastoma ( RB ) mRNA and protein levels were decreased . ^^^ SIM cells exhibited moderately increased N ras and c myc mRNA levels along with decreased levels of RB mRNA and protein . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
AGM 1470 does not inhibit early G 1 mitogenic events , such as cellular protein tyrosyl phosphorylation or the expression of immediate early genes c fos and c myc , but potently inhibits phosphorylation of RB protein , a tumor suppressor retinoblastoma gene product . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We also found that apoptotic mouse 3T3 fibroblasts express c fos , c myc , c jun , and cdc 2 , as well as the upregulation of RB phosphorylation and BrdU incorporation , just before final DNA fragmentation and death . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Rb transcripts were decreased similarly in lungs from all treatment groups ( NNK / O2 = DEN / O2 = DEN alone ) in spite of large differences in PNEC hyperplasia between these groups . c myc was overexpressed in lungs from animals treated with NNK / O2 , DEN / O2 and DEN alone , in which c myc protein immunostaining occurred predominantly in non PNECs . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Unexpectedly however , over expression of RB caused an overall transcriptional activation of the c myc promoter . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In contrast , expression of cyclin E , cyclin A , and Rb phosphorylation were delayed when quiescent c myc heterozygous cells were stimulated to enter the cell cycle . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Southern and Northern blot analyses of BIL derived cell lines before and after crisis showed that they all constitutively expressed H ras and Rb and that no cell line showed rearrangement , amplification , or overexpression of c myc , H ras , Rb , and p 53 either before or after crisis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Southern blot hybridization analysis failed to show evidence of bcl 1 , bcl 2 , c myc proto oncogene or retinoblastoma ( Rb ) tumor suppressor gene rearrangements in these six cases of Richter ' s syndrome . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The oncoproteins associated with cell cycle regulation ( cyclin D , p 53 , Rb , and c myc ) have shown strong promise of providing important prognostic information . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The `` low risk ' ' human papillomavirus types ( HPV 6 or 11 ) were determined by in situ hybridization and PCR amplification followed by direct sequencing using consensus primers from the highly conserved L 1 region in six different condylomas . mRNA levels of certain cytokines ( e . g . , TGF beta 1 , IFN beta ) , tumor suppressor genes ( RB , p 53 ) , c myc , epidermal growth factor receptor , and cdc 2 kinase were measured by RT / PCR . ^^^ Western blot experiments demonstrated a higher proportion of the hyperphosphorylated form of RB protein and a higher level of cdc 2 kinase and c myc , but low p 53 and TGF beta 1 levels in condylomas . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We have investigated the levels of expression of genes for c myc , c H ras , c K ras , c N ras , TGF beta and Rb in 42 morphologically transformed 10T1 / 2 cell lines , in an attempt to define the molecular mechanisms governing morphologic transformation and tumorigenicity in the 10T1 / 2 cell system . ^^^ In contrast , levels of expression for c myc , c H ras and Rb genes were not correlated with tumorigenicity . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In 45 human esophageal squamous cell carcinomas , 29 showed alterations of EGFr , c myc , int 2 , Rb and p 53 gene by Southern blot hybridization , a frequency of 15 . 6 % , 31 . 1 % , 35 . 6 % , 22 . 2 % , 6 . 7 % , respectively . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Therefore , we investigated bcl 2 , p 53 , and retinoblastoma gene ( Rb ) expression immunohistochemically ; the occurrence of bcl 2 , c myc , and Rb gene rearrangements using Southern blotting ; and the presence of ras and p 53 gene somatic mutations by single strand conformation polymorphism assay in a panel of 18 well characterized ALCLs . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
APC / MCC , RAS , DCC , p 53 mutations and / or allelic losses , hyperexpression of c MYC and RB genes , as well as other genomic alterations appear at characteristic stages of tumor development and are observed in most neoplasms . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We collected cells of the 327th passage of SO Rb 50 , purified its genomic DNA and detected it with Rb and c myc cDNA probes respectively ( normal human white blood cells DNA was the control ) . ^^^ We found the Rb gene was deleted while c myc gene was amplified three times . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Alterations involving three other cancer related genes associated with human esophageal carcinogenesis , c erbB 1 / epidermal growth factor receptor ( EGFR ) , c myc , and retinoblastoma ( Rb ) , were examined by Southern blot or immunohistochemical analysis in the same sample set to explore the possibility of a link between oncogene activation and loss of tumor suppressor function . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We analysed the expression of c myc , N myc , L myc , max and RB 1 mRNAs in a panel of human gliomas and glioma cell lines and compared the findings with normal neural cells . ^^^ We conclude that ( 1 ) glioma cells in vivo may coexpress several myc genes , thus resembling fetal neural cells ; but ( 2 ) cultured glioma cells expression only c myc ; ( 3 ) myc , max and RB 1 are regulated independently in glioma cells ; and ( 4 ) alternative processing of max mRNA in some glioma cells results in delta Max encoding mRNAs not seen in normal fetal brain . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In an attempt to understand the molecular pathogenesis of these tumors , we have investigated the involvement of dominantly acting oncogenes ( c myc , N , K , H Ras ) , tumor suppressor genes ( p 53 , RB 1 ) , and Epstein Barr virus ( EBV ) infection in 27 AIDS NHL samples ( 16 SNCCL , 5 LC IBP , and 6 LNCCL ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Some rat cell lines were euploid by chromosome number , but three specific genes , c myc , c raf 1 and Rb , were not always diploid . ^^^ Only one cell line , an early passage subclone of the Rat 1 cell line , was diploid for c myc , c raf 1 and Rb . ^^^ Expression patterns of the c myc , c raf 1 and Rb genes and several properties of the gene products were found to be normal . ^^^ Thus , by both genetic and physiological criteria the TGR 1 cell line is a good model system for the analysis of the roles of c myc , c raf 1 and Rb in signal transduction , and will probably prove useful in studies involving other genes . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The retinoblastoma ( RB ) protein is implicated in transcriptional regulation of at least five cellular genes , including c fos , c myc , and transforming growth factor beta 1 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Other less clearly defined abnormalities in astrocytomas include mutations of the retinoblastoma ( RB ) gene and overexpression of platelet derived growth factor ; transforming growth factor alpha and beta ; the c erb B 1 , c myc , ras , c fos , and ros oncogenes ; and insulin like growth factor 1 and 2 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Twenty four tumor tissues and one human cell strain established from an osteosarcoma were examined by Southern blot analysis using a recessive oncogene ( p0 . 9R and p3 . 8R derived from a cDNA of the Rb gene ) and eight dominant oncogenes ( c myc , c K ras , c fos , c raf 1 , c fms , c sis , N myc , and c erb B ) as probes . ^^^ All cases with c myc amplification had alterations in the structure of the Rb locus , and these patients showed rapid clinical malignancy progression and a probable tendency to bone metastases . ^^^ Results of this study suggest that structural alterations of the Rb gene and amplification of c myc might play an important role in the clinical course and pathogenesis of osteosarcoma . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The putative transregulatory activity of the RB ( retinoblastoma tumor suppressor ) gene product on the expression of the c myc and c fos proteins during the cell cycle was assessed in HL 60 promyelocytic leukemia cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Nine of these genes ( H ras , c myc , c fos , c jun , junB , N myc , c abl , c yes , and p 53 ) were expressed in epithelial cells , whereas two ( RB 1 and N ras ) were not . expression of four other genes ( c src , K ras , c raf , and c myb ) was observed , but the intensity of these bands was too low for densitometric analysis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The most common alterations found in esophageal cancers include allelic losses at chromosomes 3p , 5q , 9p , 9q , 13q , 17p , 17q and 18q , as well as mutations of p 53 ( mostly missense ) , Rb ( deletions ) , cyclin DI ( amplifications ) and c myc ( amplifications ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
By ABC immunostaining with specific antibodies , expression of proteins coded for growth regulatory genes , including Ki 67 , Topo 2 , Pol alpha , c MYC , p 53 , Rb , bcl 3 , bcl 2 , and BM 1 , was found to be variably altered in transformed cells compared with immortalized cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
IFN gamma caused a rapid ( within 12 24 h ) down regulation of cyclin A , c myc , and cdc 2 proteins , as well as a disappearance of hyperphosphorylated forms of the retinoblastoma family proteins , Rb and p 130 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
C myc expression and gene structure were studied using Northern and Southern blot techniques Rb protein expression was analyzed by Western blot . ^^^ No correlation between loss of Rb protein and c myc expression was observed . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The high levels of c myc transcripts and protein could regulate myeloma cell proliferation and apoptotic death by controlling p 53 expression and , through it , the expression of the Rb and BAX genes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In the absence of TGF beta 1 , transient expression of RB in 5 Abl expressing cells resulted in decreased c myc transcription , inhibition of GAL 4 E2F 1 driven transactivation and inhibition of cellular proliferation . ^^^ In summary , these studies established that in myeloid cells : ( 1 ) 5 Abl binds RB resulting in increased E2F 1 driven c myc transcription , and ( 2 ) an alternative pathway exists for TGF beta 1 mediated growth inhibition of 5 Abl transformed cells , in which increased rather than decreased E2F mediated c myc transcription is observed . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In the absence of this morphology , both the GI cyclin kinase inhibitor p21 / WAF 1 and positive proliferative signals including c myc and cyclin DI were expressed and the retinoblastoma protein ( Rb ) continued to be hyperphosphorylated . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Other downstream targets for ceramide action include Cox , IL 6 and IL 2 gene expression , PKC zeta , Vav , Rb , c Myc , c Fos , c Jun and other transcriptional regulators . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Our results suggest that alterations of c myc , N myc , and c fos oncogenes occur in osteosarcomas , in addition to those previously described for the tumor suppressor genes RB and p 53 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Candidate tumor suppressor genes and oncogenes affected by this trio of consistent changes include the c myc gene on chromosome 8q24 , the RB gene at 13q14 , and potentially multiple novel genes on the short arm of chromosome 8 , with a gene located more proximally potentially involved in tumor initiation and a gene or genes located more distally involved in tumor progression . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Karyotype , H ras , c myc and mutant p 53 gene expression , Rb , G 1 and S phase cyclins , E2F and major cyclin / CDK inhibitors such as p 16 and p 21 and p glycoprotein were analyzed using cytogenetic , Northern blot and immunological methods . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The down modulating effects of the inhibitors on the expression of the following cell cycle regulators have been examined : c myc , cyclin D 1 and D 2 , cdk 4 , Rb phosphorylation , E2F binding activity , ribonucleotide reductase subunits , and PCNA . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Defects in p21WAF1 / CIP1 , Rb , and c myc signaling in phorbol ester resistant cancer cells . ^^^ Treatment of SKBr 3 and LNCaP cells with PMA was followed by Raf 1 hyperphosphorylation , p 21 induction , Rb hypophosphorylation , c myc down regulation and growth inhibition . ^^^ The 10 remaining PMA resistant cell lines were comprised of 5 that failed to induce p 21 and 5 that induced p 21 but had defects in steps putatively downstream of this ( Rb hypophosphorylation and c myc down regulation ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
This interaction between Rb and E2F1 , which is subject to the level of cAMP , is critical to transcriptional control of c myc . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We and others have previously shown that the SP family of mammalian transcription factors regulates the transcription of a number of genes whose activities are governed by the product of the retinoblastoma ( Rb ) susceptibility gene , including c FOS , c MYC , TGFbeta 1 , IGF 2 , and c JUN . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We recently reported that in Madin Darby canine kidney ( MDCK ) epithelial cells the binding of LT to RB family proteins results in a massive apoptosis and a concomitant down regulation of c myc . ^^^ The stable retransformation of MDCK ( LT ) with a RB and / or c myc expressing vector restores the expression of epithelial characteristics . ^^^ Our data therefore suggest an important role for RB and c myc in modulating the epithelial phenotype both during normal tissue development and in invasive processes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Transcriptional activation of the human c myc gene by simian virus 40 large T antigen without binding to p 53 and RB proteins in the transient expression system . ^^^ CAT assay using mutated T antigen lacking p 53 or the RB binding site indicated that p 53 or RB was not mainly involved in transcriptional activation of the c myc gene . ^^^ It appears that activation of the c myc gene by T antigen is probably dependent upon E2F and a cellular factor through a mechanism which is independent of binding of T antigen to p 53 and RB . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Interference with c myc expression and RB phosphorylation during TNF mediated growth arrest in human endothelial cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The normal range of expression for each of 6 oncoproteins ( c myc , c fos , c neu , bcl 2 , p ras , p 53 mutant ) and 2 tumour suppressor gene products ( p 53 wild and Rb ) was determined in plasma cells from 33 normal bone marrows . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Immunocytochemical analysis demonstrated positive nuclear staining for WAF 1 , Rb protein , c myc , and p 53 both in the original and metastatic tumors . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
These antigens included the labelling index ( LI , bromodeoxyuridine ) , number of nucleoside transporter per cell , p glycoprotein ( JSB 1 ) , and oncoprotein expression ( c myc , c fos , c neu , bcl 2 , p ras , p53m , p 53w , and Rb ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
But the transcriptional expression of c fos , c myc , c jun , H ras , 5 erb B oncogenes and Rb antioncogene in atherosclerotic lesion has not yet been reported . ^^^ The results showed that the atherosclerotic plaques contained 3 4 fold more 5 sis , c fos and c myc mRNA ( P < 0 . 01 ) , 2 fold more c jun and H ras mRNA ( P < 0 . 01 ) , and less Rb mRNA ( P < 0 . 05 ) than those in the normal aortic arteries . ^^^ These results indicate that the abnormal expression of 5 sis , c myc , c fos , c jun , and H ras oncogenes and Rb antioncogene may play an important role in arterial SMC proliferation and pathogenesis of atherosclerosis . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Also in bladder carcinoma the study of cellular differentiation markers has been replaced by that of genotypic alterations , and , mainly with the help of immunohistochemistry , of the expression of genes involved in cell proliferation and death , such as MTS 1 , TP 53 , Rb , c myc , Bcl 2 , c erb B 2 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In addition to anti apoptotic survival mechanisms , involving abnormalities of several oncogenes and suppressor genes ( ras , c myc , p 53 , Rb and bcl 2 ) , the broad resistance spectrum might be explained but clinical studies which include the evaluation of resistance factors are missing . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The inhibition of Rb ( type 1 ) phosphatase and ICE / CED 3 like protease activities , and the abrogation of c myc expression , are mechanisms which could explain the anti apoptotic action of cAMP increasing agents in myeloid cells . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Bladder carcinoma can arise from genetic changes that may activate the oncogenes ( c erbB 2 , c erbB 1 , c myc , ras , etc . ) and / or inactivate the suppressor genes ( p 53 , Rb ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
RESULTS : Analyzing mRNA levels of various epithelial genes ( c myc , cdc 2 kinase , E2F , PCNA , p 53 , and RB , cytokeratins 5 and 10 ) we concluded that MCCs express markers of epithelial hyperproliferation together with markers of neuroendocrine differentiation ( NSE ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
C myc , retinoblastoma ( Rb ) , carcinoembryonic antigen ( CEA ) , and alkaline phosphatase ( AP ) expression was assessed by immunoblotting . ^^^ In LS174T cells , ASO caused a dose dependent decrease in c myc and Rb protein expression , but an increase in CEA and AP expression . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of beta actin , EGFR , c cerbB 2 , MTS 1 , k ras , RB , BRCA 1 , cyclin E , and c myc genes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Moreover , the core protein is implicated in the regulation of the transcription of cellular genes including c myc , RB and p 53 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Other genetic alterations detected in mouse lung tumors include reduced expression of Rb and p 16 , and increased c myc expression . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Molecular genetic abnormalities such as bcl 2 , c myc , ras , p 53 , and Rb genes have been identified in this disease and are related to a poor prognosis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
To explain these findings , expression of Bcl 2 , Bax , c Myc and RB protein and mutations of the p 53 gene were analysed . ^^^ Overexpression of c Myc and loss of RB was found in U 1285 cells whereas both U 1906 and U 1810 cells expressed RB and showed lower c Myc expression . ^^^ RB loss and overexpression of c Myc may enhance apoptosis in U 1285 cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
This family includes the MDS 1 EVI1 gene inactivated in myeloid leukemia , the PRDI BF1 / BLIMP1 transcription repressor of c myc involved in driving B cell differentiation , and the RIZ gene , which encodes proteins capable of binding to the retinoblastoma tumor suppressor protein ( Rb ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
RB and c Myc activate expression of the E cadherin gene in epithelial cells through interaction with transcription factor AP 2 . ^^^ We recently reported that inactivation of RB family proteins by simian virus 40 large T antigen ( LT ) in MDCK epithelial cells results in a mesenchymal conversion associated with invasiveness and a down regulation of c Myc . ^^^ Reexpression of RB or c Myc in such cells allows the reexpression of epithelial markers including E cadherin . ^^^ Here we show that both RB and c Myc specifically activate transcription of the E cadherin promoter in epithelial cells but not in NIH 3T3 mesenchymal cells . ^^^ Moreover , they define RB and c Myc as coactivators of AP 2 in epithelial cells and shed new light on the significance of the LT RB complex , linking it to the dedifferentiation processes occurring during tumor progression . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The relative importance of p 53 , c Myc , Rb , and the Bcl 2 homologs in the regulation of apoptosis in different human cancers is not clear . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
To test this hypothesis , a recently developed quantitative reverse transcriptase polymerase chain reaction method was used to assess simultaneously expression of 15 genes mechanistically associated with cell cycle control ( c myc , E2F 1 , p 21 , rb , PCNA , cyclin D 2 , cyclin D 3 , cyclin E , cdc 2 , CDK 2 , CDK 4 , mad , max p 21 , max p 22 , and p 53 ) in normal cell cultures from five individuals and in nine different malignant BEC lines . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Immunohistochemistry was used to localize the products of c myc , c erB 2 , RB , BCL 2 , P 21 , and P 53 genes and anti cytokeratin was used to identify fetal cells amongst the maternal decidual cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In cells with exogenous c myc expression , retinoblastoma ( Rb ) was constitutively hyperphosphorylated , regardless of whether the cells were growth arrested by EGF withdrawal or were traversing the cell cycle following EGF stimulation . ^^^ The abnormal phosphorylation status of Rb in c myc overexpressing cells was associated with premature activation of cdk 2 kinase activity , reduced p 27 expression , and early onset of cyclin E expression . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
To investigate the regulatory mechanism of the expression of the multidrug resistance gene ( mdr 1 ) and the multidrug resistance associated protein gene ( mrp ) , we investigated if p 53 , WT 1 , RB , C myc , N myc , cyclin D 1 , p16INK4 ( p 16 ) are involved in the acquirement of multidrug resistance phenotype ( MDR ) in human vincristine ( VCR ) resistant cells of leukemia / lymphoma cell lines . ^^^ Although the change in the expression level of cyclin D 1 and p 16 accompanied the development of VCR resistance , the mRNA of RB , C myc and N myc showed no correlation with the degree of VCR resistance or the level of mdr 1 expression . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
High levels of c myc gene expression were observed in five of six tumors with E 7 expression , suggesting that a pathway involving E 7 , inactivation of Rb , and activation of c myc is important in tumorigenesis of HPV 16 in these transgenic animals . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
JeKo 1 cells were Epstein Barr virus negative and showed a B cell phenotype with IgM+ , IgD+ , CD 3 , CD5+ , CD 10 , CD19+ , CD20+ and CD 23 ; they overexpressed cyclin D 1 , Bcl 2 , c Myc and Rb proteins . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We have used FISH to determine the level of synchronisation in replication timing of four pairs of alleles , unrelated to chromosome 21 ( p 53 , HER 2 , RB 1 , and c myc ) , in foetal ( amniotic fluid ) cell samples of Down syndrome and in normal foetuses . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Changes in the expression of c myc , RB and tyrosine phosphorylated proteins during proliferation of NIH 3T3 cells induced by hyaluronic acid . ^^^ Stimulation of proliferation was also accompanied by increase in c Myc protein , which was inhibited by amlloride , an inhibitor of Na+ / H+ antiporter and EGTA and increase in the steady state level of pRb , the RB gene product . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Large T antigen ( LT ) expressed by the oncogenic DNA virus SV 40 transforms cells by interacting with and perturbing the normal function of several important cellular proteins including P 53 , RB , c MYC , and AP 2 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The growth arrest and downregulation of c myc transcription induced by ceramide are related events dependent on p 21 induction , Rb underphosphorylation and E2F sequestering . ^^^ Ceramide induced downregulation of the c myc promoter was restored in SAOS 2 # 1 cells in which a functional Rb gene was reintroduced . ^^^ Our studies demonstrate that pRb dephosphorylation , induced by ceramide , is at least partly necessary for c myc downregulation , and therefore the CDK Rb E2F pathway appears to be a target for the ceramide induced modulation of cell cycle regulated gene transcription . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Dual color interphase FISH was performed to B cell Non Hodgkin ' s lymphomas to detect numerical genetic alterations in c MYC , RB 1 , TP 53 and centromere 8 and 17 . ^^^ The probe combinations c MYC / centromere 8 , RB 1 / centromere 8 and TP53 / centromere 17 were applied , and the hybridization signals scored in a correlated fashion . ^^^ Numerical alterations in c MYC and RB 1 were not associated with prognosis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Together , these results demonstrated that amplified c myc , mutant p 53 , and RB 1 genes seem to be important in osteosarcoma tumorigenicity and that an additional altered gene or genes on chromosome 22 may play a key role in osteosarcoma tumorigenicity . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
To identify the possible genes included in the abnormal chromosome regions , selected cases were analyzed for P 53 , P 16 ( INK4a ) , RB , C MYC , N MYC , BCL 2 , BCL 6 , CDK 4 , and BMI 1 gene alterations . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Frequent inactivation of PTEN / MMAC1 tumor suppressor gene at 10q23 , MXI 1 at 10q25 , KAI 1 at 11p11 . 2 , Rb at 13q14 . 2 , and p 53 at 17p13 . 1 and deregulation of c myc oncogene at 8q24 have recently been the subject of intense scrutiny and debate . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
MEN 1 gene , although found in some sporadic tumors , is more likely associated with familial adenoma . p 53 , Ras , Rb , nm 23 and c myc genes play some role in the promotion of tumors especially toward their aggressive variant . p 53 gene , which is found in up to 60 % of ACTH producing adenomas , through action of p 21 inhibits progression of cell cycle from G 1 to S phase , by inhibiting the action of cyclin D 3 on cdk 4 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Adenovirus mediated transfer of wild type p 53 gene sensitizes TNF resistant MCF 7 derivatives to the cytotoxic effect of this cytokine : relationship with c myc and Rb . ^^^ This correlated with a significant down regulation of c myc in both TNF resistant cell lines and a decrease of Retinoblastoma protein ( Rb ) in 1001 clone . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Fluorescence in situ hybridization was used to identify chromosome gains or losses for the cyclin D 1 , p 53 , Rb and c myc genes and the ploidy of their respective chromosomes . ^^^ Cyclin D 1 gene amplification , but normal copy numbers of p 53 , Rb and c myc , and normal ploidy of chromosomes 8 , 11 , 13 and 17 were observed . ^^^ In the absence of p 53 , Rb or c myc abnormalities , the results suggested that cyclin D 1 gene amplification and its protein overexpression may be involved in the genesis of renal pelvic carcinomas associated with phenacetin abuse . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
E cadherin expression was previously shown to be activated by RB and c myc specifically in epithelial cells , through interaction with the AP 2 transcription factor . ^^^ In addition , overexpression of c myc 2 or c myc 1 inhibited c myc and RB mediated activation in a dose dependent manner , suggesting that the ratio of the two c Myc proteins is essential for transactivation . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The distal segment of the mitogenic signaling pathway , which consists of Rb phosphorylation , the release of E2F , the induction of c myc , cyclins E and A , and DNA synthesis , is distinguished by a multiplicity of nested positive feedback loops ; these would be expected to drive a mitogenic signal that entered the distal segment through at least one round of DNA synthesis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Several proto oncogenes and tumor suppressor genes have been implicated in the regulation of telomerase activity , both directly and indirectly ; these include c Myc , Bcl 2 , p 21 ( WAF 1 ) , Rb , p 53 , PKC , Akt / PKB , and protein phosphatase 2A . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In order to investigate a possible link between the two tumours , we investigated mutations in the p 53 gene , loss of heterozygosity ( LOH ) at p 53 , Rb and p 16 , c Myc expression , and the telomerase activity of the angiomyolipoma and the osteosarcoma . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Genetic changes associated with the development of ESCC include mutation of the p 53 gene , disruption of cell cycle control in G 1 by several mechanisms ( inactivation of p16MTS1 , amplification of Cyclin D 1 , alterations of RB ) , activation of oncogenes ( e . g . , EGFR , c MYC ) and inactivation of several tumor suppressor genes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
CDP / cut is cell cycle regulated through interactions with Rb , p 107 , specific kinases and phosphatases directing the transcriptional activity of CDP / cut on such genes encoding p 21 ( WAF 1 , CIP 1 ) , c myc , thymidine kinase , and histones . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In Swiss 3T3 cells , PMT induced up regulation of c Myc ; cyclins D 1 , D 2 , D 3 , and E ; p 21 ; PCNA ; and the Rb proteins , p 107 and p 130 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
BRCA 1 contains several functional domains that interact directly or indirectly with a variety of molecules , including tumor suppressors ( p 53 , RB , BRCA 2 and ATM ) , oncogenes ( c Myc , casein kinase 2 and E2F ) , DNA damage repair proteins ( RAD 50 and RAD 51 ) , cell cycle regulators ( cyclins and cyclin dependent kinases ) , transcriptional activators and repressors ( RNA polymerase 2 , RHA , histone deacetylase complex and CtIP ) and others . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
This linkage has been recognized for tumor suppressor genes such as p 53 and RB , the dominant oncogene , c Myc , and several cyclin dependent kinases ( Cdks ) and their regulators . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Our results suggest that YY 1 , acting as a transcription factor binding to its site on the promoter , or through protein protein interaction with AP 2 , may be part of a regulatory network including key cell cycle regulators such as c Myc and Rb in controlling growth and differentiation regulated gene expression . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
RB , CDK 4 , MDM 2 , c myc , c fos , and p 53 gene expression , which are the major genes involved in osteosarcoma susceptibility , were studied . ^^^ Our results revealed an inactive form of p 53 sporadically seen in the samples , a total loss of Rb protein expression , an increased expression of Cdk 4 , MDM 2 , c fos , and c myc proteins which literature currently reports being the principal alterations found in osteosarcoma . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Northern blot hybridization showed increased expression of RB gene and decreased expression of c myc gene in 11A1 R 1 , 11A1 R 2 cells compared to 11A1 cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Amplification of H ras and c myc oncogenes and mutations of p 53 , nm 23 and Rb genes have been identified disproportionately more in aggressive tumors and , in the case of Rb gene , in pituitary carcinomas , providing evidence that amplification of these oncogenes ( H ras and c myc ) and inactivation of tumor suppressor genes ( p 53 , nm 23 and Rb ) seem to be at least one mechanism by which pituitary tumors progress . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
These genes were Rb ; p 21 ( WAF1 / CIP1 ) ; bad ; cdk 2 ; cyclins A , D 3 , E 1 ; c myc ; egr 1 ; iNOS ; and FasL . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
OBJECTIVE : To study the effect of compound Chinese drug Bailong on the transcription of Cyclin Dependent Kinase Inhibitor ( CKI ) p16INK4a , p 21 and Rb , c myc genes , and the relationship between gene expression and cAMP PKA pathway . ^^^ Being same as p16INK4a , tumor suppressor genes Rb , p 21 and oncogene c myc expression were all affected by Bailong . ^^^ CONCLUSION : Bailong can affect many anticancer genes ( including p16INK4a , p 21 and Rb genes ) and oncogenes ( including c myc ) transcription by regulating cAMP PKA pathway . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the expressions of p 53 , c myc ( oncogene ) and proliferating cell nuclear antigen ( PCNA ) in retinoblastoma ( Rb ) and the relationships of the expression to the degree of differentiation and optic nerve infiltration . ^^^ METHOD : The expressions of p 53 , c myc and PCNA in Rb tissues of 31 cases were analyzed by using LSAB immunohistochemical method . ^^^ RESULTS : The positive rates of p 53 , c myc and PCNA in Rb were respectively 51 . 6 % , 45 . 2 % and 67 . 7 % and all the expressions were significantly related to the differentiation degree of Rb ( all P < 0 . 05 ) . ^^^ Both the expressions of p 53 and c myc in Rb were markedly correlated with the expression of PCNA ( all P < 0 . 05 ) . ^^^ The determinations of p 53 , c myc and PCNA are of significance for evaluating the histologic characteristics and biological behavior of Rb . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Expression of EBNA 2 and some of the key players regulating G1 / S phase transition such as c myc expression , phosphorylation of Rb protein , expression of G 1 cyclins , and the cyclin dependent kinase inhibitor p 27 were followed . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The quantitative expansion of the Rb , p 53 , c myc , and Her 2 / neu alterations towards high grade carcinomas suggests common pathogenetic mechanisms in the spectrum of these neoplasms . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
METHODS : The expression of various oncoproteins ( p 21 , EGFR 1 , erbB 2 , c jun , c myc , bcl 2 , Bax ) and suppressor gene products ( WT 1 , RB gene , p 53 ) was studied in normal urothelium , transitional cell carcinoma ( TCC ) cell lines and their MDR sublines by using specific antibodies and an indirect immunofluorescence flow cytometric method . ^^^ They had a low expression rate of c myc , Bax and RB gene when compared to normal urothelium . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In eight of the tumors we observed whole or partial gain of chromosome 15 centering on 15D2 D 3 ( orthologous to human chromosome 8q24 ) , the map location of the c Myc gene , and six of the tumors exhibited copy number loss of whole or partial chromosome 14 , including 14D3 , the map location of Rb 1 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
For some of these genes , an overexpression or downregulation of the encoded protein was confirmed ( cyclin D 1 , c myc , BMI 1 , cystatin c , SPARC , RB ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
METHODS : In this study , the effect of inhibition of beta hCG and c myc singly or in combination was evaluated in DU 145 ( RB / , p 53 / , androgen independent ) and LNCaP ( Rb+ / + , p 53 + / + , androgen sensitive ) human prostate cancer cell lines and in a DU 145 subcutaneous xenograft murine model . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The nuclear arrangement of the ABL , c MYC , and RB 1 genes was quantitatively investigated in human undifferentiated HL 60 cells and in a terminally differentiated population of human granulocytes . ^^^ The ABL gene was expressed in both cell types , the c MYC gene was active in HL 60 cells and down regulated in granulocytes , and expression of the RB 1 gene was undetectable in HL 60 cells but up regulated in granulocytes . ^^^ In both cell types , the c MYC and RB 1 genes were located at the periphery of the chromosome territories regardless of their activity . ^^^ Close spatial proximity of the c MYC and RB 1 genes with centromeric heterochromatin , forming the chromocenters , correlated with gene activity , although the nearest chromocenter of the silenced RB 1 gene did not involve centromeric heterochromatin of chromosome 13 where the given gene is localized . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
With Northern blot analysis , 2 was found to inhibit the expression of c myc gene in A 549 cells and have no marked effect on H ras oncogene expression , and increase the cellular P 53 mRNA contents , though it did not affect the expression of RB tumor suppressor gene . 2 also suppressed the P 46 ( JNK / SAPK ) expression in A 549 cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In RA sensitive cell lines , ATRA induced G0 / G1 arrest is associated with down regulaton of c myc and hyperphosphorylated Rb expression , and up regulation of p21WAF1 / CIP1 and p 53 expression . ^^^ These results indicate that growth inhibition , rather than apoptosis , is correlated with G0 / G1 arrest of these cell lines , more important molecules related cell cycle , including c myc , p21WAF1 / CIP1 , p 53 and Rb , are involveed in regulation of cell cycle in gastric cancer cells . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the common regulative effects of the Chinese drug Bailong and hexamethylen bisacetamide ( HMBA ) on expressions of oncogenes ( c H ras and c myc ) , and tumor suppressor genes ( Rb , p 53 and p 21 ) of MGC 80 3 in human cancer cell cycle . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
It interacts directly or indirectly with a variety of important proteins , including oncogene proteins ( c myc , E2F ) , tumor suppressor proteins ( p 53 , RB , BRCA 2 ) , DNA damage repair proteins ( RAD 50 , RAD 51 ) , cell cycle regulators ( cyclin , CDK ) , transcriptional regulators ( RNA polymerase 2 ) and others related to the important biological events . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Quantitative reverse transcription polymerase chain reaction verified mRNA changes in this group , which included gadd45a , c myc , cyclin D 1 and cdk 4 , pcna , cyclin G , Rb , and E2F5 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Expression of the apoptosis related proteins p 53 , p 21 , Rb , bcl 2 , bax , c myc , Fas and Fas L was assessed immunohistochemically . ^^^ Untreated , both tumors were equally positive for p 53 , bax , Fas , Fas L , c myc and negative for Rb . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Direct regulation of RNA polymerase 3 transcription by RB , p 53 and c Myc . ^^^ These observations may be explained by the fact that a pol 3 specific transcription factor , TFIIIB , is strongly regulated by the tumor suppressors RB and p 53 , as well as the proto oncogene product c Myc . ^^^ The ability to regulate pol 3 output may therefore be integral to the growth control functions of RB , p 53 and c Myc . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
AIM : To investigate the relationship between Helicobacter pylori ( H . pylori ) infection and the expressions of the p 53 , Rb , c myc , bcl 2 and hTERT mRNA in a series of diseases from chronic gastritis ( CG ) , intestinal metaplasia type 1 or 2 ( IMI 2 ) , intestinal metaplasia type 3 ( IMIII ) , mild or modest dysplasia ( DysI 2 ) , severe dysplasia ( DysIII ) to gastric cancer ( GC ) and to elucidate the mechanism of gastric carcinogenesis relating to H . pylori infection . ^^^ H . pylori infection and the expressions of p 53 , Rb , c myc , bcl 2 were detected by means of streptavidin peroxidase ( SP ) immunohistochemical method . ^^^ RESULTS : The expressions of p 53 , Rb , c myc , hTERT mRNA and bcl 2 were higher in the GC than in CG , IM , Dys . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
While kinase inhibitors restore susceptibility of cancer cells to apoptosis , they do not necessarily cause growth arrest in cancer cells harboring additional mutations in downstream signaling pathways such as inactivation of Rb and overexpression of c myc . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Despite this oncogenic lesion , Y 1 cells retain tight regulatory mechanisms of cell cycle control typified by the sequential events comprising the mitogenic response triggered by FGF 2 in G0 / G1 arrested Y 1 cells : 1 ) activation of ERK1 / 2 and PI3K , by 5 minutes ; 2 ) induction of c Fos and c Myc proteins by 2 hours ; 3 ) induction of cyclin D 1 protein by 5 hours ; 4 ) phosphorylation of Rb protein between 6 and 8 hours ; 5 ) onset of DNA synthesis by 8 9 hours . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
For FISH the following probes were used : MLL , CBF beta / MYH11 , ETV 6 / AML1 ; AML1 / ETO , BCR / ABL , PML / RAR , c MYC , TP 53 , RB 1 , 5q31 / 5p15 . 2 , 5q33 34 , 7q31 / CEP7 , 20q13 ; CEP 4 , 10 , Y . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In previous investigations , we reported that loss of heterozygosity at the Rb gene locus , telomerase activity , hTERT , and c Myc expression were associated with tumor progression in liposarcomas . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Notably , c Myc is able to induce cells to enter S phase in quiescent cells through an Rb / E2F independent pathway . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Prostatic glandular epithelial cells express protein kinase Cepsilon ( PKCepsilon ) , an oncoprotein that coordinately disrupts the reactivation of the tumor suppressor Rb , derepressess transcriptional elongation of the c myc oncogene , and propagates survival signals in LNCaP cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Novel functions have been revealed for RB , p 53 and c Myc , that may help explain their profound biological effects . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
To gain an insight into the possible underlying pathways , cell culture experiments were performed focusing on the expression of p 21 , Rb and c myc . ^^^ Standard Western blot analysis was performed for protein expression of p 21 , Rb and c myc in HDAC treated vs untreated prostate cancer cells . ^^^ As demonstrated by Western blot analysis , these effects seem to be independent of p 53 status and a pathway via p 21 Rb c myc is possibly involved . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The cell cycle regulation related proteins CDK 2 , Rb and c myc were inhibited by PH 2 7 in a dose dependent manner , whereas the expression of CyclinE was increased after exposure to PH 2 7 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
To assess the cellular mechanisms underlying the mesangial cell proliferation and glomerulosclerosis in progressive human IgA nephropathy ( IgAN ) , we examined the expression of E2F1 , Rb , c Myc , proliferating cell nuclear antigen ( PCNA ) , cyclins ( D 1 , E and A ) , cyclin dependent kinase 2 ( CDK 2 ) and CDK inhibitors ( p 21 ( waf 1 ) , p 27 ( kip 1 ) , 57 ( kip 2 ) and p 16 ( ink4a ) ) by immunohistochemistry in renal biopsy specimens . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Alterations of chromosomes ( 3p , 5q , 9p ) , genes ( Rb , C myc , C mos , hTERT ) , proteins ( p 16 , p 53 , K ras , hnRNP A2 / B1 , MCM 2 , EGFR , erbB 2 , erbB 3 , erbB 4 ) and others can be found in lung cancer . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We found that Rz 170 reduced the expression of the viral E 6 and E 7 proteins , and cellular c myc , bcl 2 proteins , but increased the expression of p 53 and Rb proteins . ^^^ It is likely that the ribozyme inhibited cervical cancer cell growth by reducing the expression of the HPV 16 E6 and E7gene , which may alter the expression of p 53 , Rb , c myc and bcl 2 , and led to apoptosis in cancer cells . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In general , the checkpoint for replicative senescence is found at the G ( 1 ) / S border , controlled by the modulation of a battery of proteins , typified by gaining inhibitors of cell cycle traverse , such as cyclin dependent kinases or RB hyperphosphorylation , and losing pro proliferation gene expressions such as c fos , c myc , and a cadre of proliferation dependent kinases . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Our results demonstrated that 16 genes ; bad , bax , bcl 2 , bcl w , bcl 10 , caspase 3 , caspase 7 , caspase 8 , c myc , E 124 , GADD 45 , mdm 2 , NKkappab 1 , p 53 , p 21 , Rb and trail were up regulated and six genes ; caspase 1 , caspase 2 , DR 5 , E2F1 , FasL and iNOS did not changed in response to DES treatment in wild type mice compared to p53+ / knockout mice . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Microarray analysis by ATRA treatment for 48 hr in peripheral blood mononuclear cells ( in vivo ) and in cultured bone marrow mononuclear cells ( in vitro ) from a patient with APL revealed upregulation of CD11b , CD11c , CCAAT enhancer binding protein epsilon , Rb 1 , Mad , and tumor necrosis factor related genes ; and downregulation of hTERT , c Myc , WT 1 , bcl 2 , and eukaryotic translation elongation factor 1alpha2 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : An inverse polymerase chain reaction ( PCR ) based methodology was used to amplify rearrangements that had occurred between one of four target regions ( in or neighbouring the avian myelocytomatosis viral oncogene homologue ( c MYC ) , cyclin dependent kinase inhibitor 1A ( CDKN1A ) , fibroblast growth factor receptor 2 ( FGFR 2 ) , or retinoblastoma 1 ( RB 1 ) genes ) and sequences elsewhere in the genome , following gamma irradiation and subsequent incubation at 37 degrees C of normal human IMR 90 fibroblasts . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
All cases were analyzed for chromosomal aberrations commonly observed in nodal large B cell lymphomas , including structural aberrations of the genes BCL 2 , BCL 6 , and c MYC , and numerical aberrations of the chromosomes / genes 3 , 7 , 8 , 11 , 12 , 13 , 17 , 18q , RB 1 , and p 53 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Detailed analysis of expression of selected genes in beta carotene treated LNCaP cells at the level of mRNA and protein indicated that the observed increase of proliferation could have been the result of slight induction of a few genes affecting proliferation ( c myc , c jun ) and apoptosis ( bcl 2 ) with no significant effect on major cell cycle control genes ( cdk 2 , RB , E2F 1 ) . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In contrast , transformation of multiple strains of human fibroblasts requires the constitutive expression of c Myc , H RAS , and hTERT , together with loss of function of the p 53 , RB , and PTEN tumor suppressor genes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Moreover , the upregulation of p 21 was followed by the inactivations of cdk 4 and cdk 2 , the hypophosphorylation of Rb , and a marked decline in the expression of c myc ( a gene regulated by E2F that is a transcription factor whose activity is suppressed when it is bound to hypophosphorylated Rb ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Immunoblotting analyses demonstrated that Epimedin C caused a decreased expression of hyperphosphorylated retinoblastoma ( Rb ) protein , cyclin D 1 , c Myc , and c Fos . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for cell cycle regulators [ p 53 , p 21 , p 27 , p 16 , cyclin D 1 , Rb ] , apoptosis related proteins [ Fas , Fas L , FADD , TRAIL , DR 4 , DR 5 , caspase 8 , caspase 3 , bcl 2 , Bax ] , tumor suppressor proteins [ beta catenin , E cadherin , FHIT , Smad 4 , VHL , PTEN , KAI 1 ] , and oncoproteins [ c myc , COX 2 , EGFR ] . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
RhoB facilitates c Myc turnover by supporting efficient nuclear accumulation of GSK 3 . ^^^ Recent studies link RhoB to trafficking of Akt , which through its regulation of glycogen synthase kinase 3 ( GSK 3 ) has an important role in controlling the stability of the c Myc oncoprotein . c Myc stabilization may be a root feature of human tumorigenesis as it phenocopies an essential contribution of SV 40 small T antigen in human cell transformation . ^^^ In this study we show that RhoB directs efficient turnover of c Myc in established or transformed mouse fibroblasts and that the attenuation of RhoB which occurs commonly in human cancer is a sufficient cause to elevate c Myc levels . ^^^ Increased levels of c Myc elicited by RhoB deletion increased the proliferation of nullizygous cells , whereas restoring RhoB in null cells decreased the stability of c Myc and restrained cell proliferation . ^^^ Mechanistic analyses indicated that RhoB facilitated nuclear accumulation of GSK 3 and GSK 3 mediated phosphorylation of c Myc T 58 , the critical site for ubiquitination and degradation of c Myc . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
DMBA induced mammary tumors exhibited elevated expression of the aryl hydrocarbon receptor ( AhR ) , c myc , cyclin D 1 , and hyperphosphorylated retinoblastoma ( Rb ) protein . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Previous studies in fibroblasts have shown that the pol 3 specific transcription factor IIIB ( TFIIIB ) is bound and regulated by the proto oncogene product c Myc , the mitogen activated protein kinase ERK and the retinoblastoma tumour suppressor protein , RB . ^^^ However , hypoxic conditions cause TFIIIB dissociation from c Myc and ERK , at the same time as increasing its interaction with RB . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The loss of Rb protein did not appear to permit transit to S phase , and was not accompanied by an expression of c Myc . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
APC / MCC , RAS , DCC , p 53 mutations and / or allelic losses , hyperexpression of c MYC and RB genes ) , as well as other genomic alterations , appear at characteristic stages of tumor development and are observed in most neoplasms . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Since neurofibromatosis type 1 ( NF 1 ) patients are at an increased risk to develop malignancies , we used the fluorescence in situ hybridization ( FISH ) replication assay and evaluated the level of replication synchrony of three cancer implicated genes ( RB 1 , AML 1 , and CMYC ) in lymphocytes derived from patients with NF 1 without malignancy . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
These changes include activation of dominant oncogenes myc family , ( K ras and neu genes ) , as well as loss of recessive growth regulatory genes or anti oncogenes ( p 53 , and RB as well as unidentified gene or genes on chromosome 3 ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Increasing numbers of alterations have been found in protooncogenes ( e . g . , ras , myc ) , as well as tumor suppressor genes ( e . g . , p 53 , Rb ) in various types of tumors . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
These genes include 1 ) those important to androgen metabolism in the prostate , the androgen receptor and steroid 5 alpha reductase genes ; 2 ) those that map to the 10q ( PLAU ) and 7q ( MET ) chromosomal regions found deleted in some prostate carcinomas , and 3 ) proto oncogenes ( ERBB 2 , INT 2 , and MYC ) and tumor suppressor gene loci ( RB 1 , TP 53 and D17S5 ) found altered in adenocarcinomas of the breast , colon and lung . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
A summary of what is known about some of these regulatory oncogenes ( fos , jun , myc , and Rb 1 ) and where they might function in the progression of a cell from G 0 to G 1 and G 1 to S is presented . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Some of the activated proto oncogenes and tumor suppressor genes are more selectively expressed or absent in small cell lung cancer ( L myc , c myb , c scr , Rb gene ) or non small cell lung cancer ( c erbB 2 , c sis , c fes ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The oncogenes imminently affecting surgical pathology practice are those of the ras , myc , HER 1 2 , and int families , and putative suppressor genes such as the Rb gene . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
RESULTS : Apoptotic proteins in tumors that showed positive staining were the highest for Bax ( 99 % ) , Fas ( 92 % ) , FasL ( 87 % ) , Rb ( 87 % ) , p 21 ( WAF 1 ) ( 73 % ) , and p 53 ( 70 % ) , and the lowest for c myc ( 58 % ) and Bcl 2 ( 58 % ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Oncogenes ( H ras , erbB 2 , EGFR , MDM 2 , C MYC , CCND 1 ) , tumor suppressor genes ( p 53 , Rb , p 21 , p27 / KIP1 , p 16 , PTEN , STK 15 , FHIT , FEZ1 / LZTS1 , bc 10 ) , telomerase , and methylation have all been studied in bladder cancer . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
CONCLUSIONS : Our results suggest that APC functions upstream of RB in the G ( 1 ) / S regulatory pathway , cyclin D 1 and cMYC affect APC mediated arrest equivalently to oncogenic beta catenin , and most colon tumors disrupt control of G ( 1 ) / S progression by APC mutation . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Transcripts coding for transcription factors ( RB , P 53 , FOS , MYC , MYB , ERBA , REL ) , growth factors ( FGF 1 , FGF 2 , INT 2 , TGFA , TGFB , PDGF , IGF 1 , IGF 2 ) , interleukins , ( IL 1 , IL 2 , IL 3 , IL 4 , IL 6 , TNF ) , growth factor receptors or cytosolic protein kinases ( RAF , PIM , FES , MET , SRC , ROS , TRK , KIT , CSFR , IGFR , PDGFR , EGFR , NEU ) were quantified in cultured human mammary fibroblasts from normal tissues , benign tumours , carcinomas and post radiation fibrosis lesions by slot blot autoradiography and image analysis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
For many others , such as MYC , CCND 1 , EMS 1 , EGF , RB 1 , NME , DCC and prohibitin , the evidence is still largely circumstantial , or obtained only by in vitro studies on breast cancer cell lines . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The present report summarizes the current molecular biological aspects of several oncogenes ( erbB , ras , myc , raf , fos , jun , bcl , mdm 2 , myb , kit CSF1R , met ) and tumor suppressor genes ( p 53 , rb , mts ) involved in lung cancer development with respect to the pathology of lung tumors , including the importance of these genes as far as the clinical course of the disease is concerned . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
No expression of Rb or p 53 was detected in REC : myc or the alpha particle induced REC : myc transformants . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Activated cellular oncogenes ( myc and ras , for example ) and inactivated anti oncogenes ( p 53 or Rb ) participate in multistep carcinogenesis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Both Rb ( 6 . 15 ) and T ( 14 ; 15 ) persisted together with G myc and R myc . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The DNA PK catalyzed phosphorylation of synthetic peptides corresponding to Myc and RB proteins in a DNA dependent manner , indicating that DNA PK may recognize a second core sequence motif Pro Ser / Thr in addition to the putative consensus sequences of Ser / Thr Gln . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In situ hybridization was performed on the normal and the inverted Rb chromosomes , using myc and kappa probes . ^^^ On the normal Rb chromosome , myc was in the 15 D2 / 3 region , whereas kappa hybridized in the 6 C 2 area , as expected . ^^^ On the inverted Rb chromosome , myc remains on the centrometric side of the translocation breakpoint on the chromosome 15 derived portion , whereas kappa has moved to the chromosome 6 derived segment that joined the same breakpoint on the telomeric side . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
DNA diagnostic techniques are being introduced rapidly into the clinical laboratory setting . 1 ) In lung cancer , several oncogenes and tumor suppressor genes , such as ras , myc , p 53 , RB , allelic loss of chromosomes , play very important roles . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The increase in copy number at 8q24 ( MYC ) and decreases at 17p13 ( TP 53 ) , 13q14 ( RB ) , and 3p have previously been identified in SCLC with other methods . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Recent experimental results suggest that RB 1 may exert its growth suppressing activity by regulating the transcription of a variety of growth related genes , including FOS , MYC , and TGFBI . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Loss of Rb and Myc activation co operate to suppress cyclin D 1 and contribute to transformation . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Such genes include K ras , p 53 , rb , myc , her2 / neu , and probably one or more tumor suppressor genes on chromosome 3p . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The blast crisis of CML has been variably associated with abnormalities of proto oncogenes , such as RAS and MYC , or of tumour suppressor genes , in particular RB , p 53 and p 16 , or with the generation of chimeric transcription factors , as in the AML 1 EVI1 gene fusion . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In the glioblastomas with no alterations of CDKN2A , CDK 4 or RB 1 , several other genes ( CCND 1 , CCND 2 , CCND 3 , CDK 6 , E2F , CDK 7 , MYC and MYCN ) whose products take part in cell cycle regulation were examined . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The selected markers were growth regulators ( p 53 , Rb and myc ) , metastasis suppressor gene product ( nm 23 ) , adhesion molecules ( Ep CAM , E cadherin , CD44v5 and CD44v6 ) and urokinase type plasminogen activator ( u PA ) . ^^^ For curative resectability , a significant association was found with Rb and E cadherin expression , while in multivariate analysis Rb and myc were selected as the combination with additional independent prognostic value , and E cadherin had no additional independent value . ^^^ For overall survival in univariate analysis , the amount of both eosinophilic and lymphocytic infiltrates and Rb and myc expression were of significant prognostic value . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The following markers were selected on their putative role in the process of metastasis and were studied using immunohistochemical and / or Southern blot techniques : proliferating cell nuclear antigen ( PCNA ) , p 53 , retinoblastoma tumor suppressor gene ( Rb ) , myc , bcl 2 ( inhibitor of apoptosis ) , epidermal growth factor ( EGF ) , EGF receptor ( EGFR ) , neu , nm 23 ( also known as NME 1 , putative metastasis suppressor ) , desmoplakin , neuron cell adhesion molecule ( N CAM ) , epithelial cell adhesion molecule ( Ep CAM ) , E cadherin , cyclin D 1 ( CCND 1 ) , and EMS 1 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The molecular changes include activation of dominant oncogenes ( myc family , K ras and HER / 2 / neu genes ) , as well as loss of recessive growth regulatory genes or anti oncogenes ( p 53 , and rb as well as unidentified gene or genes on chromosome 3 ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Using CAT reporter co transfection assays we show here that transcription from the MYC P 2 promoter is induced efficiently by E2F 1 , but repressed by RB . ^^^ We also find that expression of G 1 phase cyclin D 1 leads to an E2F binding site dependent trans activation of the MYC promoter and that this activation can be abrogated by overexpression of RB . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Under continuous carcinogens exposition these proliferating cells accumulate multiple genetic abnormalities affecting dominant oncogenes such as myc and ras , and recessive tumor suppressor genes such as Rb and p 53 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
RESULTS : Molecular mechanisms altered in lung cancer include induced expression of oncogenes , such as RAS , MYC , c erbB 2 , and BCL 2 , and loss of tumor suppressor genes , such as RB , p 53 , and p16INK4A . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Twenty primary central nervous system lymphomas ( PCNSL ) from immunocompetent patients ( nineteen B cell lymphomas and one T cell lymphoma ) were investigated for genetic alterations and / or expression of the genes BCL 2 , CCND 1 , CDK 4 , CDKN1A , CDKN2A , MDM 2 , MYC , RB 1 , REL , and TP 53 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
New techniques for early detection of lung cancer based on molecular changes ( i . e . mutations in p 53 , K ras and rb , amplification of myc and Her 2 / neu , deletion of 3p , and microsatellite instability ) in sputum or bronchoalveolar lavage fluid may be used as tools in diagnosis and prognosis , as well as in screening programs . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Activated cellular oncogenes ( myc and ras , for example ) and inactivated anti oncogenesis ( p 53 or Rb ) participate in multistep carcinogenesis . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In this study we compared the expression of several proteins ( p 53 , Rb , cyclin D 1 myc , bcl 2 , EGFR , neu , E Cadherin , Ep CAM , Desmoplakin 1 and nm 23 ) in the three major sites of HNSCC ( larynx , pharynx , and oral cavity ) . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Re expression of myc activates the cell cycle without inducing apoptosis . myc triggers the expression of cyclin D 2 , cyclin E and Cdk 4 , followed by the activation of cyclin E associated kinase and hyper phosphorylation of Rb . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Moreover , we find that p16INK4a and the Rb related protein p 107 which releases Myc after phosphorylation by cyclin D1 / CDK4 efficiently block Myc ' s activity as a transcriptional transactivator and as an oncogene . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Such alterations include mutations of ras genes , overexpression of myc or erbB 2 genes and inactivation of RB genes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Mutations of Rb and P 53 genes can be associated with metastatic disease , mutations of the ras gene is rare whereas elevated level of myc oncogene are frequent but of little prognostic value . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The development of a lung cancer requires multiple genetic changes , consisting of the activation of oncogenes , including the K ras and myc genes , and of inactivation of tumour suppressor genes , including the Rb , p 53 and CDKN 2 genes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
FISH analysis of gene aberrations ( MYC , CCND 1 , ERBB 2 , RB , and AR ) in advanced prostatic carcinomas before and after androgen deprivation therapy . ^^^ Fluorescence in situ hybridization ( FISH ) analysis of dissociated nuclei with DNA probes for MYC ( 8q24 ) / # 8 , cyclin D 1 gene ( CCND 1 ; 11q13 ) / # 11 , ERBB 2 ( 17q13 ) / # 17 , the androgen receptor gene ( AR ; Xq 12 ) / # 10 , and the retinoblastoma gene ( RB ; 13q14 ) was applied to formalin fixed tissue from 63 patients with advanced PC after androgen deprivation therapy ( ADT ) ; matched tumor tissue before ADT was also available in 22 of these cases . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Cell cycle progression induced by Myc oncoproteins requires inactivation of Rb by Id 2 . ^^^ Thus , a dual connection links Id 2 and Rb : during normal cell cycle , Rb prohibits the action of Id 2 on its natural targets , but oncogenic activation of the Myc Id 2 transcriptional pathway overrides the tumour suppressor function of Rb . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The results indicate that activation of MYC ERTM in WI 38 cells is sufficient to cause S phase entry of quiescent cells , which is preceded by phosphorylation of Rb and activation of the Cdk 2 associated kinase . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Southern blot analyses indicated no detectable alterations in myc , ras , Rb , or p 53 genes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Corrective gene therapy to restore normal patterns of tumor suppressor gene ( p 53 , Rb , p 21 and p 16 ) expression or negate the effect of mutated tumor promoting oncogenes ( ras , myc , erbB 2 and bcl 2 ) have efficacy in animal models but this approach suffers from the fact that each cancer cell must be targeted . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
RESULTS : In contrast to non endocrine tumours of the digestive system such as carcinoma of the pancreas , colon and stomach , dNETs do not show alterations in oncogenes ( ras , Myc , fos jun , Src ) or in common tumor suppressor genes [ p 53 , retinoblastoma suspectibility gene ( Rb ) ] . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Id 2 is a natural target of the Rb protein that is recruited by Myc oncoproteins to bypass the tumor suppressor function of Rb . ^^^ Here we report that an `` N Myc Id 2 pathway ' ' persists during late development of the nervous system and parallels the rising levels of active Rb in neuronal precursors withdrawing from the cell cycle . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
The main targets of chromosomal changes are regulatory genes of cell proliferation and apoptosis ( e . g . p 16 , cyclin D 1 , Rb , p 53 , myc , bcl 2 ) and members of the signaling cascade of tyrosine kinase receptors ( e . g . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
To date , molecular genetic studies of CML BC have mainly focused on alterations of well known tumor suppressor genes ( e . g . , TP 53 , CDKN2A , and RB 1 ) and oncogenes ( e . g . , RAS and MYC ) , whereas limited knowledge is available about the molecular genetic correlates of the unbalanced chromosomal abnormalities . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Many oncogenes , gene products , and suppressor gene mutations , including those of Ras , Myc , p 53 , Rb , p 16 , p 21 , thrombospondin 1 , glutathione , and factors controlling expression and function of the epidermal growth factor receptor , have been shown to be involved in the biology of this disease . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
SAML 2 has 45 chromosomes , del ( 5 ) ( q11 . 2q31 ) with a t ( 12 ; 13 ) ins ( 12 ; 5 ) , leading to the proximity of IRF 1 and RB 1 , and complex translocations of chromosomes 8 and 11 , resulting in amplification of MYC and MLL . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We tested the importance of conserved E2F sites , based on known Myc interaction with the pRb related p 107 and on the transrepressive effects of Rb family proteins . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We studied the expression of selected tumor suppressor genes ( P 53 and retinoblastoma [ RB ] ) , oncogenes ( MYC and BCL 2 ) , and a transferrin receptor related protein ( Trump ) in sequential biopsies in 16 patients . ^^^ Immunoreactivity for RB , BCL 2 , and MYC was seldom associated with progression . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Identification and characterization of their substrates indicate that they regulate the turnover of key cell cycle proteins ( p27Kip1 , p21Cip1 , p57Kip2 , cyclin E ) , tumor suppressor proteins ( p 53 , RB ) , signaling kinases ( Src , Zap 70 , PI 3 kinase ) , apoptosis regulators ( Bcl 2 , Bax , Bik ) and transcription factors ( Myc , NF kappaB , E1F1 ) , all of which have been implicated in the pathogenesis of malignant lymphoma . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Location of Myc , Igh , and Igk on Robertsonian fusion chromosomes is inconsequential for Myc translocations and plasmacytoma development in mice , but Rb ( 6 . 15 ) carrying tumors prefer Igk Myc inversions over translocations . ^^^ The location of the Myc and immunoglobulin ( Ig ) loci on metacentric Robertsonian ( Rb ) fusion chromosomes may affect the development of mouse plasmacytomas ( Pcts ) by changing the probability with which chromosomal Myc Ig translocations occur . ^^^ Karyotyping of 70 Rb carrying Pcts demonstrated that in these tumors , just as in their counterparts in inbred C mice , the Igh heavy chain locus was translocated with Myc more often than was the Igk light chain locus . ^^^ Pcts harboring Igh or Igk on normal and Rb chromosomes showed no bias toward either in generating Myc translocations . ^^^ These findings indicated that the location of Myc , Igh , and Igk on normal or Rb chromosomes is inconsequential for Myc translocation and Pct development . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Thus , we propose that Myc and STAT 3 cooperate to induce the expression of Cdc25A and that their transcriptional activity is normally regulated by the Rb tumor suppressor gene . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
Likewise , the combined deletion of Rb plus p 130 up regulated myocardial expression of Myc , E2F 1 , and G 1 cyclin dependent kinase activities , synergistically . ^^^ Thus , Rb and p 130 have overlapping functional roles in vivo to suppress cell cycle activators , including Myc , and maintain quiescence in postnatal cardiac muscle . . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
We now show that expression of mammalian proteins that inactivate the tumor suppressors Rb and p 53 in conjunction with the oncoproteins Ras and Myc and the telomerase subunit hTERT is sufficient to drive a number of normal human somatic cells to a tumorigenic fate . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
In Myc deficient cells , despite its inability to overcome this proliferation block , 5 Src was able to regulate the expression of certain Myc transcriptional targets and induce the expression of active cyclin D / Cdk4 and Cdk 6 complexes ; it also induced the phosphorylation of Rb , albeit at reduced levels . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
SCLC is defined not only by its characteristic neuroendocrine differentiation , aggressiveness , and metastatic potential , but also by a specific set of genetic aberrations , including the loss of the tumor suppressor genes p 53 and Rb 1 and the amplification of any member of the Myc family of oncogenes . ^^^
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01106 and P06400	Pubmed	SVM Score :0.0
NA