| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| The induction of the expression of two oncogenes ( c fos and c myc ) , three heat shock protein ( HSP ) genes ( HSP 27 , HSP 70 , and HSP 89 mRNAs ) and two antioxidative enzyme genes ( Mn superoxide dismutase ( SOD ) and catalase mRNAs ) by northern hybridisation , as well as the activities of four major antioxidative enzymes ( SOD , catalase , glutathione peroxidase , and glutathione reductase ) were examined in control and 1 10 PC and 4 10 PC hearts . ^^^ RESULTS : Northern hybridisation detected enhanced level of c fos 2 . 2 kb mRNA and c myc 2 . 4 kb mRNA in 4 10 PC hearts after 60 min of reperfusion , induction being stronger for c fos . 1 10 PC hearts showed minimal expression of c fos mRNA , but not c myc mRNA . 4 10 PC hearts also showed the induction of HSP 27 , HSP 70 , and HSP 89 mRNAs as well as catalase and Mn SOD mRNAs , whereas 1 10 PC hearts showed some induction of HSP 70 mRNA and catalase mRNA only . 2 D gel electrophoresis revealed the expression of 15 20 new proteins in 4 10 PC hearts only . ^^^ CONCLUSIONS : Repeated ischaemia and reperfusion ( 4 10 PC ) , and not 1 10 PC , caused the induction of several stress related and antioxidant genes including HSP 27 , 70 , and 89 genes , Mn SOD and catalase genes , and proto oncogenes ( c fos and c myc ) , as well as the expression of several stress inducible proteins and stimulation of three antioxidative enzymes . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| The study of several human breast cancer cell lines containing oestrogen receptors has allowed characterization of a number of oestrogen induced proteins ( e . g . progesterone receptor , cathepsin D , pS 2 , Hsp 27 , c Myc ) . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| In this manner , in 11 sensitive and 11 resistant B CLL cell samples tested , 13 genes were found to be specific for all resistant samples : nuclear orphan receptor TR 3 , major histocompatibility complex ( MHC ) class 2 glycoprotein HLA DQA 1 , mtmr 6 , c myc , c rel , c IAP 1 , mat2A , and fmod were up regulated , whereas MIP1a / GOS19 1 homolog , stat 1 , blk , hsp 27 , and ech 1 were down regulated . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| Also , a number of genes that are upregulated by c Myc in cells expressing wild type conformation p 53 encode chaperones related to cell death protection as HSP 105 , HSP 90 and HSP 27 . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| Our results also indicate that elevated levels of Stat 3 phosphorylation were significantly associated with increased expression of potential downstream targets of Stat 3 which include apoptosis inhibitors ( Survivin , Mcl 1 , HSP 27 , Adrenomedullin , and Bcl xL ) , cell cycle regulators ( c Fos , MEK 5 , and c Myc ) , and inducer of tumor angiogenesis ( VEGF , COX 2 , MMP 2 , MMP 10 , and MMP 1 ) in invasive breast cancer tissues . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| Immediately following RF field exposure ( T = 6 h ) and 18 h post exposure ( T = 24 h ) , cell pellets were collected from each of the culture dishes and analyzed for transcript levels of proto oncogenes ( c jun , c myc and c fos ) and the stress related genes ( heat shock proteins ( HSP ) HSP 27 and HSP70B ) by quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ RESULTS : No significant effects were observed in mRNA expression of HSP 27 , HSP 70 , c jun , c myc or c fos between the sham and RF exposed groups , in either of the two cell lines . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| Interestingly , when overlapping genes were excluded , 12 ( e . g . , NM 23 H2 , MCM 7 , PARP 1 , YWHAH , HSPB 1 , and MSH 2 ) of the top 34 upregulated genes and five ( e . g . , MT1A and MT 3 ) of the top 33 downregulated genes were c myc regulated genes . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| Not altered in most hypertrophied hearts was expression of c fos , junB , p 53 , c neu , c myc , HSP 70 , HSP 27 , TGF beta or IGF 1 mRNAs . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| Although , the expression of Hsp 27 and Hsp 70 proteins remained unchanged , the oncogenic protein c Myc is upregulated upon DEX treatment . ^^^ |
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| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| Many genes have been selected as targets for antisense therapy , including HER 2 / neu , PKA , TGF alpha , EGFR , TGF beta , IGFIR , P 12 , MDM 2 , BRCA , Bcl 2 , ER , VEGF , MDR , ferritin , transferrin receptor , IRE , C fos , HSP 27 , C myc , C raf and metallothionein genes . ^^^ |
|
| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04792 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
|