| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.86687952 |
| Since amphiphysin 2 ( BIN 1 ) was reported to interact with Myc , it may also be implicated in a signaling pathway linking the cortical cytoplasm to nuclear function . . 0.86687952^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.51963554 |
| Bin 1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms . 0.51963554^^^ |
|
| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.70451641 |
| We report on the structural features of the interaction between c Myc and Bin 1 , and describe two mechanisms by which the binding of different Bin 1 isoforms to c Myc may be regulated in cells . 0.70451641^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| BIN 1 is a novel MYC interacting protein with features of a tumour suppressor . ^^^ BIN 1 is a novel protein that interacts with the functionally critical Myc box regions at the N terminus of the MYC oncoprotein . ^^^ Consistent with this likelihood , BIN 1 inhibited malignant cell transformation by MYC . ^^^ We conclude that BIN 1 is an MYC interacting protein with features of a tumour suppressor . . ^^^ |
|
| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| BIN 1 is a putative tumor suppressor that was identified in a genetic screen for polypeptides that interact with the MYC oncoprotein . ^^^ |
|
| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| BIN 1 is a putative tumor suppressor that was identified through its interaction with the MYC oncoprotein . ^^^ One alternately spliced exon encodes part of the MYC binding domain , suggesting that splicing controls the MYC binding capacity of BIN 1 polypeptides . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| A variety of functions of C MYC , the product of c myc , are attributed to protein protein interactions with various cellular factors including Max , YY 1 , p 107 , Bin 1 and TBP . ^^^ Max and YY 1 bind to the C terminal region of C MYC , while p 107 , Bin 1 and TBP bind to the N terminal region covering myc boxes . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin 1 , a novel Myc interacting protein . ^^^ Bin 1 is a novel protein that specifically binds Myc and inhibits , at least in part , Myc transactivation . ^^^ Since MYC family genes play a regulatory role in the proliferation , differentiation , and apoptosis of the nervous system , we studied the effects of the overexpression of the Myc interacting protein , Bin 1 , in neuroblastoma and astrocytoma cell lines , which were chosen as neural cell system models . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| Bin 1 is an adapter protein with features of a tumor suppressor that was identified through its interaction with and inhibition of the oncogenic properties of c Myc . ^^^ Exon 12A sequences abolished the ability of Bin 1 to inhibit malignant transformation by c Myc or adenovirus E1A . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| Recent data suggest that Bin 1 , a novel C MYC interacting protein , is a suppressor gene whose loss of expression is a frequent aberration associated with several malignancies . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that the MYC interacting adaptor protein BIN 1 is frequently missing in malignant breast cells and that this loss is functionally significant . ^^^ We propose that loss of BIN 1 may contribute to breast cancer progression by eliminating a mechanism that restrains the ability of activated MYC to drive cell division inappropriately . . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| Bin 1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified through its ability to interact with and inhibit malignant transformation by c Myc . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| The c Myc interacting adaptor protein Bin 1 activates a caspase independent cell death program . ^^^ The Bin 1 gene encodes a nucleocytosolic adaptor protein with tumor suppressor properties , initially identified through its ability to interact with and inhibit malignant transformation by c Myc and other oncogenes . ^^^ In support of a link to c Myc induced death processes , AEBSF , a serine protease inhibitor that inhibits apoptosis by c Myc , potently suppressed DNA degradation by Bin 1 . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that BIN 1 , a MYC interacting protein capable of inducing apoptosis , may be an important regulator of MYCN in neuroblastoma . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| Bin 1 mediates apoptosis by c Myc in transformed primary cells . ^^^ The Bin 1 gene encodes a c Myc interacting adapter protein with tumor suppressor and cell death properties . ^^^ In this study , we offer evidence that Bin 1 participates in a mechanism through which c Myc activates programmed cell death in transformed primary chick or rat cells . ^^^ Antisense or dominant inhibitory Bin 1 genes did not affect the ability of c Myc to drive proliferation or transformation , but they did reduce the susceptibility of cells to c Myc induced apoptosis . ^^^ Protein protein interaction was implicated , suggesting that Bin 1 mediates a death or death sensitization signal from c Myc . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| Using this strategy , we demonstrate interactions between the mammalian basic helix loop helix proteins MyoD and E 12 , and between c Myc and Bin 1 . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| Bin 1 holds special interest as certain splice isoforms localize to the nucleus , interact with the c Abl and c Myc oncoproteins , and display tumor suppressor properties . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| BIN 1 ( 2q14 ) encodes multiple isoforms of a Myc interacting adaptor protein that has features of a tumor suppressor , including the ability to inhibit Myc mediated cell transformation and to promote apoptosis . ^^^ We hypothesized that BIN 1 may function as a suppressor gene in NB , because Bin 1 is highly expressed in neural tissues and binds the Myc Box motifs that are conserved in MycN . ^^^ RESULTS : Four predominant BIN 1 isoforms resulting from alternative splicing of exon 12A ( a neural tissue specific exon ) and exon 13 ( a Myc binding domain encoding exon ) were variably expressed in the 56 primary NBs . ^^^ Forced expression of BIN 1 isoforms containing the Myc binding domain ( with or without exon 12A ) inhibited colony formation in NB cell lines with MYCN amplification ( P < 0 . 01 ) but not in those without . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| While these properties may reflect the ability of these isoforms to interact with and suppress the cell transforming activity of c Myc , the effects of Bin 1 deletion on the oncogenicity of c myc or other transforming genes has not been gauged directly . ^^^ Here we report that targeted deletion of Bin 1 enhances the neoplastic character of primary murine embryo fibroblasts ( MEFs ) cotransformed by c myc and mutant grasg . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| Suppression of MEK / ERK signalling by Myc : role of Bin 1 . ^^^ However , using the Myc binding domain ( MBD ) of Bin 1 , which binds to and negatively regulates the activity of Myc , we selectively suppressed Myc induced apoptosis , without affecting its transforming properties . ^^^ |
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| Interacting proteins: O00499 and P01106 |
Pubmed |
SVM Score :0.0 |
| NA |
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