| Interacting proteins: Q16520 and P01100 |
Pubmed |
SVM Score :0.0 |
| Glutathione s transferase B ATF heterodimerizes efficiently with in vitro translated JunB , c Jun , and JunD , but only weakly associates with c Fos . ^^^ |
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| Interacting proteins: Q16520 and P01100 |
Pubmed |
SVM Score :0.0 |
| B ATF functions as a negative regulator of AP 1 mediated transcription and blocks cellular transformation by Ras and Fos . ^^^ Jun / B ATF dimers display similar DNA binding profiles as Jun / Fos dimers , with a bias toward binding TRE ( 12 O tetradecanolyphorbol 13 acetate response element ) over CRE ( cyclic AMP response element ) DNA sites . ^^^ B ATF inhibits transcriptional activation of a reporter gene containing TRE sites in a dose dependent manner , presumably by competing with Fos for Jun and forming transcriptionally inert Jun / B ATF heterodimers . ^^^ This effect is dominant in the presence of the growth promoting effects of the H Ras or the 5 Fos oncoproteins , since expression of B ATF restricts the efficiency of focus formation by these transforming agents . ^^^ |
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| Interacting proteins: Q16520 and P01100 |
Pubmed |
SVM Score :0.0 |
| Tumor model specific proviral insertional mutagenesis of the Fos / Jdp2 / Batf locus . ^^^ On the basis of retroviral tag retrieval from 1190 individual Akv and SL 3 3 induced lymphomas , we here report that insertional mutagenesis into the 250 kb Fos / Jdp2 / Batf locus is associated with SL 3 3 MLV induced T but not Akv induced B cell lymphomas of NMRI and SWR mice . ^^^ Whereas elevated mRNA levels of the Fos gene could not be correlated with provirus presence , in one case , Northern blot analysis as well as quantitative real time PCR indicated proviral activation of the AP 1 super family member Batf , a gene not previously reported to be a target of insertional mutagenesis . ^^^ |
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| Interacting proteins: Q16520 and P01100 |
Pubmed |
SVM Score :0.0 |
| Furthermore , almost all kinds of the AP 1 family genes including c jun , c fos , junD , junB , atf 2 and b atf were successfully selected from an mRNA display library constructed from a mouse brain poly A ( + ) RNA after six rounds of selection . ^^^ |
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