| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| In intact cells , the ERK 2 mutants were functionally active in phosphorylating Elk 1 and RSK 1 and activating the c fos promoter . ^^^ |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| Indeed , in vitro , MAP kinase and / or RSK phosphorylates histone H 3 and the recombinant c Fos and c Jun polypeptides , transcription factors phosphorylated in a variety of cells in response to growth stimuli . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| RSK 3 also phosphorylated potential nuclear target proteins including c Fos and histones . ^^^ |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| We now provide evidence that two growth regulated , nucleus and cytoplasm localized protein kinases , 90 kDa ribosomal S 6 kinase ( RSK ) and mitogen activated protein kinase ( MAP kinase ) , contribute to the serum induced phosphorylation of c Fos . ^^^ The major phosphopeptides derived from biosynthetically labeled c Fos correspond to phosphopeptides generated after phosphorylation of c Fos in vitro with both RSK and MAP kinase . ^^^ This study suggests a role for nuclear RSK and MAP kinase in modulating newly synthesized c Fos phosphorylation and downstream signaling . . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of c Fos at the C terminus enhances its transforming activity . c Fos is phosphorylated by MAP kinase and the 90 kDa ribosomal S 6 kinase ( RSK ) in vitro at serines 362 and 374 ( rat ) which we demonstrate are major in vivo phosphorylation sites in early G 1 . ^^^ These results indicate that phosphorylation of c Fos at its extreme carboxyterminus , possibly by MAP kinase and RSK , supports the proliferative response by increasing c Fos stability and / or by increasing its transactivation activity . ^^^ The highly conserved nature of these phosphorylation sites in other c fos family members suggests that these may also be targets of MAP kinase and RSK . . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| Rsk 2 activity is necessary for epidermal growth factor induced phosphorylation of CREB protein and transcription of c fos gene . ^^^ Finally , coexpression of Rsk 2 in transfected cells results in the activation of the c fos promoter via the cAMP responsive element . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| RSK B phosphorylates the cAMP response element binding protein ( CREB ) and c Fos peptides . ^^^ |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| A number of cellular functions of RSK have been proposed . ( 1 ) Regulation of gene expression via association and phosphorylation of transcriptional regulators including c Fos , estrogen receptor , NFkappaB / IkappaB alpha , cAMP response element binding protein ( CREB ) and CREB binding protein ; ( 2 ) RSK is implicated in cell cycle regulation in Xenopus laevis oocytes by inactivation of the Myt 1 protein kinase leading to activation of the cyclin dependent kinase p34cdc2 ; ( 3 ) RSK may regulate protein synthesis by phosphorylation of polyribosomal proteins and glycogen synthase kinase 3 ; and ( 4 ) RSK phosphorylates the Ras GTP / GDP exchange factor , Sos leading to feedback inhibition of the Ras ERK pathway . . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| Ribosomal subunit kinases ( Rsk ) have been implicated in the regulation of transcription by phosphorylating and thereby activating numerous transcription factors , such as c Fos , cAMP responsive element binding protein ( CREB ) , and nuclear receptors . ^^^ Thus Rsk 2 is required for growth factor stimulated expression of c Fos and transcriptional activation of Elk 1 and the serum response factor , but not for activation of CREB or the mitogen activated protein kinase pathway in response to PDGF and IGF 1 stimulation . . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| These results suggest a signaling pathway in which Erk MAP kinase activates the c fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF 1 and CREB . . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| Both myrWT RSK and myrCTT RSK can signal to the RSK substrate c Fos in the absence of mitogen activation . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| However , when ERK signalling is sustained , c Fos is phosphorylated by still active ERK and RSK ( 90K ribosomal S 6 kinase ) . ^^^ |
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| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| Several genes were selected from p 53 related genes ( CDKN1A , TP53I11 and CDC 14 ) , Akt 2 related genes ( PRKCD , BRCA 1 , TRIB 3 and APPL ) , mitogen activated protein kinase related genes ( RSK and SH3BP5 ) , Ras superfamily genes ( RAP1GA1 , RHOC and ARHGDIA ) and AP 1 family and related genes ( RIP 140 , FOS , ATF 3 , JUN and FRA 2 ) . ^^^ |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15418 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
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