| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :1.2084602 |
| We show that c Fos interacts with STAT 1 after IFN gamma activation and the c Fos / STAT 1 complex binds to the gamma activated site ( GAS ) element in close proximity to AP 1 sites located at 4 . 9 kb upstream of the transcription start site . 1.2084602^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| Moreover , TFII 1 can form in vivo protein protein complexes with the c fos upstream activators SRF , STAT 1 , and STAT 3 . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| One consequence of the activation of STAT 91 in the nucleus is the appearance of GH stimulated DNA binding activity , as assessed by gel mobility shift assay using an oligonucleotide containing a c sis inducible element from the c fos promoter . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| The Stat 91 pathway regulated c fos gene transcription involves activation by tyrosine phosphorylation of the DNA binding factor SIF ( sis inducing factor ) in the cytoplasm , its nuclear translocation , and interaction with the regulatory element SIE ( sis inducing element ) . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| GH activation of the two groups of Stats leads to their selective binding to DNA response elements upstream of the c fos gene ( c sis inducible enhancer element ; Stat 1 and Stat 3 binding ) and the beta casein gene ( mammary gland factor element ; liver Stat 5 binding ) . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| Treatment of cells with EGF activates Stat 1 and Stat 3 , which become phosphorylated on tyrosine residues to form homo or heterodimers and translocate into the nucleus , binding to the sis inducible element ( SIE ) in the c fos promoter . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| In NK3 . 3 cells , IL 2 induced comparable formation of c fos promoter sis inducible element IFN gamma activated sequence binding complexes containing STAT 3 alone with complexes containing STAT 3 and STAT 1 alpha , while in preactivated primary NK cells , it preferentially induced complexes containing STAT 3 and STAT 1 alpha . ^^^ However , supershift analyses using the c fos promoter sis inducible element probe showed that IL 12 activated STAT 4 , STAT 1 alpha , and STAT 3 , and induced complexes containing STAT 4 only , STAT 4 with STAT 1 alpha , STAT 3 with STAT 1 alpha , or STAT 1 alpha only in preactivated primary NK cells . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| Upon IL 10 treatment Stat 1 , 3 , and 5 bind to the GRR of the FcgammaRI gene , activated Stat 1 and 3 bind to the SIE sequence of the c fos promoter and transcriptionally active Stat 5 assembles at the PRL STAT consensus sequence of the beta casein gene . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| Differential activation of signal transducer and activator of transcription ( STAT ) 3 and STAT 1 transcription factors and c fos messenger ribonucleic acid by interleukin 6 and interferon gamma in Sertoli cells . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| The effects of the testicular cytokines , interleukin 6 ( IL 6 ) and interferon gamma ( IFN gamma ) , on signal transducers and activators of transcription 3 and 1 ( STAT 3 and STAT 1 ) and on c fos gene expression in primary Sertoli cells are suggestive of their roles in differential function . ^^^ Using the tyrosine phosphorylation inhibitor , genistein , and electrophoretic mobility shift assay , we show that IL 6 and IFN gamma induce nuclear factor STAT 3 and STAT 1 DNA binding activity to the sis inducible element of c fos in a genistein dependent pathway . ^^^ H 7 , a serine / threonine phosphorylation inhibitor , also blocks c fos gene induction by IL 6 and IFN gamma , but does not affect the DNA binding activities of STAT 3 and STAT 1 . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| Testicular leukemia inhibitory factor ( LIF ) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription ( STAT ) 3 and STAT 1 and induce c fos transcription and activator protein 1 activation in rat Sertoli but not germ cells . ^^^ In addition , we characterized the effects of LIF on the signal transducers and activators of transcription ( STAT ) 3 and STAT 1 , c fos gene expression , and activator protein 1 regulation in primary rat Sertoli cells . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| G CSF , but not SCF , induces the tyrosine phosphorylation of STAT 1 and STAT 3 , transcription factors that can mediate the induction of c fos . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| Moreover , geldanamycin interfered with mitogen induced phosphorylation of extracellular signal regulated kinase and transcription of c fos and Egr 1 , but not with transactivation of STAT 1 transcription factor . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We show that interleukin 6 , leukemia inhibitory factor and interferon gamma treatment induce the nuclear STAT 3 and STAT 1 proteins to bind to the sis inducible element of c fos in both C 6 glioma cells and primary cortical astrocytes . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| We present evidence here that STAT 3 and not STAT 1 accumulates on the chromosomal c fos promoter and provides a boost to transcription without the activation of resident nuclear proteins through serine kinases . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| Thus , under overexpression of c fos gene , c Fos inactivates STAT 1 to down regulate p21waf1 / cip1 gene expression in the lymphocytes of patients with RA , and in this way may enhance proliferation of lymphocytes . . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| The upregulated genes fall into several categories including antioxidants : ceruloplasmin , metallothionein , and heme oxygenase ; antiapoptotic gene : bag 3 , chloride channels : clic 1 and clic 4 ; transcription factors : c fos , fra 1 , junB , stat 1 , krox 24 and c / ebp ; secreted signaling molecules : chitinase 3 like protein 1 and osteopontin ; inflammation related genes : MCP 1 and ICAM 1 and others . ^^^ |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P42224 |
Pubmed |
SVM Score :0.0 |
| NA |
|