| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.68847661 |
| This study examines the genetic response in cultured human keratinocytes exposed to a single solar simulated ultraviolet dose and harvested at 1 , 4 , 8 , 24 , and 48 hours postirradiation for northern blot analysis using c DNA probes to well studied stress related genes , heat shock protein 70 and ubiquitin ; to a recently cloned gene associated with growth arrest and DNA damage ( gadd 153 ) ; to c myc and c fos , two proto oncogenes known to be associated with cell growth and differentiation ; and to glyceraldehyde phosphate dehydrogenase , known to be involved in cellular intermediary metabolism , gadd 153 and c fos mRNA levels are increased early ( 1 4 hours ) in keratinocytes , at a time when the cells appear indistinguishable from nonirradiated controls . 0.68847661^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Here we show that CHOP interacts with members of the immediate early response , growth promoting AP 1 transcription factor family , JunD , c Jun , and c Fos , to activate promoter elements in the somatostatin , JunD , and collagenase genes . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| CHOP dimerizes with and inhibits the binding of C / EBP related transcription factors to their consensus DNA target sequences and also forms novel complexes with other transcriptional proteins ( e . g . c Jun , c Fos ) . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Their gene products encode proteins involved in the regulation of cell growth ( proto oncogenes c myc and c fos ) , a gene inducible by growth arrest and DNA damage ( GADD 153 ) , the cytokine interleukin ( IL ) 1 alpha and beta and finally a differentiation associated small proline rich gene ( SPR 2 ) . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| We have explored the mechanisms involved in the induction of five stress response genes ( heme oxygenase [ HO ] , c fos , Egr 1 , gadd 153 , and HSP 70 ) in human diploid fibroblasts growth arrested by treatment with the antiproliferative prostaglandin A 2 ( PGA 2 ) . ^^^ The kinetics of c fos and Egr 1 induction were found to be rapid with maximum expression occurring within 60 min of treatment , whereas maximum expression of HO , gadd 153 , and HSP 70 occurred between 4 and 8 h of treatment . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Specific mRNA was detected using cDNA probes encoding the proto oncogenes c fos and c myc and the growth arrest and DNA damage ( GADD 153 ) gene , all recently shown by our laboratory to be modulated by UV in newborn keratinocytes ; interleukin ( IL ) 1a , IL 1b , and the IL 1 receptor antagonist ( IL 1ra ) , two keratinocyte cytokines and their competitive inhibitor , implicated in the immunomodulatory effect of UV ; and SPR 2 , a recently cloned gene known to be induced during normal keratinocyte differentiation and by lethal UV C irradiation . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Unlike GADD 45 , the response of other DNA damage inducible genes to IR is not dependent on p 53 based on the observation that induction in a panel of cell lines did not correlate with a normal p 53 status ; this included human GADD 153 , another member of the gadd ( growth arrest and DNA damage inducible ) group ; MyD 118 , a gene related to GADD 45 ; and the protooncogenes c jun and c fos . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Indeed , exposure of cells to oxidants or UVC stimulated binding of Fos and Jun to the GADD 153 AP 1 element . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NaDOC was found to activate transcription factors and induce or activate the promoters of genes that respond to protein malfolding ( grp 78 and hsp 70 ) , DNA damage ( gadd 153 , hsp 70 and c fos ) , oxidative stress ( NF kappaB , c fos , hsp 70 and gadd 153 ) , ER stress ( grp 78 ) and Ca++ imbalance ( grp 78 ) . . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Gene expression studies using RNase protection assays , reverse transcription PCR , and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth , such as c fos , c jun , and EGR 1 , as well as cell arrest , such as GADD 153 and GADD 45 . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| The stress response elements chosen were the c fos promoter , the gadd 153 promoter , and p 53 response element repeats . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| As ( 5 ) , at doses of 50 250 microM , produced a complex profile of activity showing significant dose dependent induction of the hMTIIA , GST Ya , HSP 70 , FOS , XRE , NFkappaBRE , GADD 153 , p53RE , and CRE promoters . ^^^ Whereas Cr ( 3 ) yielded small , though significant inductions of the CRE , FOS , GADD 153 , and XRE promoters only at the highest dose ( 750 microM ) , Cr ( 6 ) produced significant dose related inductions of the p53RE , FOS , NFkappaBRE , XRE , GADD 45 , HSP 70 , and CRE promoters at much lower doses , in the range of 5 10 microM . ^^^ Our results thus show metal activation of gene expression through several previously unreported signal transduction pathways , including As ( 5 ) induction of GST Ya , FOS , XRE , NFkBRE , GADD 153 , p53RE , and CRE ; Pb ( 2 ) induction of GST Ya , XRE , Cyp IA 1 , and GADD 153 ; Cd ( 2 ) induction of NFkBRE , Cyp IA 1 , XRE , and GST Ya ; and Cr ( 6 ) induction of p53RE , XRE , GADD 45 , HSP 70 , and CRE promoters , and thus suggest new insights into the biochemical mechanisms of toxicity and carcinogenicity of metals . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Increases occurred in oxidative stress responsive genes HO 1 , QR , HSP 70 , GADD 45 , GADD 153 , p 21 ( WAF1 / CIP16 ) , GST ' s , GAPDH , TPX , and GPX 1 ( 0 ) ; transcriptional regulators c jun , c fos , jun B , c myc , and IkappaB ; protein repair components Rdelta , RC 10 2 , C 3 , RC 7 , HR6B ubiquitin conjugating enzyme and ubiquitin ; DNA repair components PCNA , msh 2 , and O 6 methylguanine DNA methyltransferase ; lipid peroxide excision enzyme PLA 2 ; and apoptogenic components TNFalpha , iNOS 1 and FasL . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Marginal inductions were also recorded for the c fos , and 153 kDa growth arrest DNA damage ( GADD 153 ) promoters , indicating a potential for CdCl 2 to damage DNA . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| Co exposure of HepG 2 cells to atrazine also resulted in a significant increase in the potency of arsenic trioxide to upregulate a number of stress genes including those of the glutathione S transferase Ya subunit GST Ya , metallothioneinIIa HMTIIA , 70 kDa heat shock protein HSP 70 , c fos , 153 kDa growth arrest and DNA damage ( GADD 153 ) , 45 kDa growth arrest and DNA damage ( GADD 45 ) , and 78 kDa glucose regulated protein GRP 78 promoters , as well as the xenobiotic response element XRE , tumor suppressor protein response element p53RE , cyclic adenosine monophosphate response element CRE , and retinoic acid response element RARE . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| These results indicate the potential for lead nitrate to undergo biotransformation in the liver ( XRE ) , to cause cell proliferation ( c fos ) , protein damage ( HSP 70 , GRP 78 ) , metabolic perturbation ( CRE ) , and growth arrest and DNA damage ( GADD 153 ) . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| DU , ( 5 50 microg / ml ) produced a complex profile of activity demonstrating significant dose dependent induction of the hMTIIA FOS , p53RE , Gadd 153 , Gadd 45 , NFkappaBRE , CRE , HSP 70 , RARE , and GRP 78 promoters . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the metabolism of iprodione involves Phase 2 biotransformation in the liver ( XRE , GSTYa ) , and that this chemical has the potential to cause cell proliferation and / or inflammatory reactions ( c fos , NF kB ) , proteotoxic effects ( HSP 70 , GRP 78 ) , metabolic disruption ( CRE ) , and DNA damage ( GADD 45 , GADD 153 ) . . ^^^ |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35638 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
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