Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Wortmannin also inhibited the increase in c fos mRNA induced by PDGF , which is dependent on ERK activation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
PTF also reduced PDGF induced c fos mRNA expression , which is dependent on activation of the RAS / ERK pathway . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Phosphorylation of the TCFs Elk 1 and Sap 1a by the ERK and JNK subclasses of MAP kinases triggers c fos transcription . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Conversely , PKC activation resulted in a rapid , but transient induction of c fos RNA and of both kinases , JNK 1 and ERK 2 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Neuregulin induced expression of immediate early genes c jun and c fos , which followed and depended on the ERK activation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Further , phosphorylation of ERK is essential for c fos activation via SRE cis element . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The results show that ERK and p 38 cooperate in contraction stimulated activation of c fos transcription . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Phosphorylation of elk 1 by MEK / ERK pathway is necessary for c fos gene activation during cardiac myocyte hypertrophy . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The stimulatory effect is mediated through the immediate induction of c fos gene by activating ERK of MAPK . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Exposure to HNE caused ERK , JNK , and p 38 MAP kinase activation as well as the induction of c fos and c jun gene expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
This is followed by phosphorylation of Erk 1 / 2 peaking at 5 minutes and expression of c fos mRNA within 30 minutes . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Negative regulation of ERK and Elk by protein kinase B modulates c Fos transcription . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In contrast , ET induced ERK activation and c fos gene expression were predominantly regulated by EGFR . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
However , the expression of ERK cascade dependent genes , such as c fos and IL 1beta , was extremely limited . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
PKC zeta is required for angiotensin 2 induced activation of ERK and synthesis of C FOS in MCF 7 cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
At 1 h after the peak of p ERK expression these cap cells express c fos , Period 1 , and Period 2 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Bonjardim , Plasminogen / plasmin regulates c fos and egr 1 expression via the MEK / ERK pathway , Biochem . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Epithelial injury induces egr 1 and fos expression by a pathway involving protein kinase C and ERK . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Elevated ERK MAP kinase activity protects the FOS family member FRA 1 against proteasomal degradation in colon carcinoma cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In this paper , we report that overexpression of GAP blocks the phorbol ester ( tetradecanoyl phorbol acetate [ TPA ] ) induced activation of p 42 mitogen activated protein kinase ( p42mapk ) , c fos expression , and DNA synthesis . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Previously , we and others have demonstrated that oncogenic forms of Raf 1 kinase , when expressed in fibroblasts , lead to the constitutive activation of ERK 2 , the de regulation of c fos expression and increased cell proliferation . ^^^ In Rat 6 cells , although both ERK 1 and ERK 2 are activated in response to mitogens that induce c fos expression , such as Epidermal Growth Factor ( EGF ) , lysophosphatidic acid ( LPA ) or serum , expression of 5 Raf fails to induce c fos expression and increase proliferation . ^^^ The co transfection of an interfering mutant of ERK 2 has no effect on the level of c fos reporter expression in Rat 6 cells whereas the analogous ERK 1 mutant reduces its expression . ^^^ Thus , not only do mitogenic signals appear to by pass both Raf 1 kinase and ERK 2 , the Raf 1 ERK 2 pathway seems to be functionally compromised in Rat 6 cells as its activation leads neither to c fos expression nor to increased proliferation . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In this study , expression of dominant interfering mutants of SHPTP 2 was found to inhibit insulin stimulation of c fos reporter gene expression and activation of the 42 kDa ( Erk 2 ) and 44 kDa ( Erk 1 ) mitogen activated protein kinases . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Moreover , activation of the ERK pathway was necessary and sufficient for the c Fos phosphorylation and stabilization by Mos . ^^^ These results indicate that c Fos undergoes stabilization , and mediates at least partly the oncogenic signalling , by the Mos / MEK / ERK pathway . ^^^ The present findings also suggest that , in general , the ERK pathway may regulate the cell fate and function by affecting the metabolic stability of c Fos . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
To determine how , after UVB irradiation , signal transduction pathways , DNA damage , and cell cycle arrest interact in the human melanocyte , we analyzed here the possible activation of tyrosine kinases , the serine threonine kinases Baf 1 and ERK 2 , the status of the transcription factor c fos , and the activation of cell cycle checkpoints induced by expression of p 53 protein . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NGF induced phosphorylation of the trkA receptor , activated a cascade of cellular intermediaries such as phospholipase C gamma 1 and ERK proteins , and stimulated c fos gene transcription in all trkA expressing clones . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Inhibition of 5 raf dependent c fos expression and transformation by a kinase defective mutant of the mitogen activated protein kinase Erk 2 . ^^^ In NIH 3T3 fibroblasts , 5 raf activates Erk 2 , and overexpression of an interfering mutant of Erk 2 both blocks the ability of 5 raf to activate the c fos promoter and suppresses transformation . ^^^ These results provide compelling evidence that phosphorylation of TCF / Elk 1 by Erk 2 is a major link in the Raf 1 kinase dependent signal transduction pathway that activates c fos expression . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Inhibition of tyrosine phosphatase activities by sodium vanadate treatment delays but does not block ERK 2 inactivation , TCF dephosphorylation , and c fos repression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Ras can stimulate AP 1 activity by inducing c fos transcription , a process which is probably mediated by the ERK 1 and 2 mitogen activated protein ( MAP ) kinases , which phosphorylate the transcription factor Elk 1 / TCF . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Mitogen activated protein kinases ( MAP ) or extracellular signal regulated protein kinases ( ERK ) are a family of protein serine / threonine kinases that are activated very rapidly in response to many extracellular stimuli . elk 1 , an ets related gene codes for two transcriptional factors elk 1 , which regulates c fos transcription and delta elk 1 , both of which are substrates for MAP kinases . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Elk 1 ( also called p62TCF ) , a transcription factor involved in the induction of the expression from the c fos promoter through the promoter ' s serum response element , is known to be activated as a result of phosphorylation by the MAP kinases ERK 1 and ERK 2 . ^^^ However , induction of c fos expression in response to noxious agents takes place in the absence of ERK activation . ^^^ Expression of the SAPK upstream activator kinase , MEKK 1 , induces SAPK activation and c fos transcription in the absence of ERK activity . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Neither ERK nor JNK / SAPK MAP kinase subtypes are essential for histone H3 / HMG 14 phosphorylation or c fos and c jun induction . ^^^ The effects of EGF , TPA , UV radiation , okadaic acid and anisomycin on ERK and JNK / SAPK MAP kinase cascades have been compared with their ability to elicit histone H3 / HMG 14 phosphorylation and induce c fos and c jun in C3H 10T1 / 2 cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Expression of constitutively active MKK induce ERK 2 kinase activity and caused expression from the c Fos promoter , but did not significantly activate expression of reporter genes under the control of either the ANF or MLC 2 promoters . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The reduced ERK 2 activity in response to EGF was associated with decreased c fos and c jun mRNA expression and lower levels of AP 1 transcription factor DNA binding activity in the aged hepatocytes . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
As determined by immunohistochemical staining and phosphotyrosine blotting , the functional responses to acute stimulation with BDNF , NT 3 and NT 4 / 5 , including c Fos induction and phosphorylation of Trk and extracellular signal regulated kinase ( ERK ) proteins , were significantly decreased after 6 days in culture by prior exposure to BDNF . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The ERK , JNK / SAPK and p38 / RK MAP kinase subtypes ( reviewed in [ 1 ] ) are differentially activated in mammalian cells by various stimuli , which elicit induction of immediate early ( IE ) genes , such as c fos and c jun ( reviewed in [ 1 3 ] ) , as well as phosphorylation of histone H 3 [ 4 ] and HMG 14 [ 5 ] . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
As Elk 1 is most likely phosphorylated while bound to the c fos promoter , these results suggest that UV irradiation and MEKK 1 activation stimulate TCF / Elk 1 activity through JNK activation , while growth factors induce c fos through ERK activation . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling induced ERK activation and c fos gene expression in cardiac myocytes . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The p 38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c fos transcription in response to UV light . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
IRS 1 deficiency results in a 70 to 80 % reduction in IGF 1 stimulated cell growth and parallel decreases in IGF 1 stimulated S phase entry , PI 3 kinase activity , and induction of the immediate early genes c fos and egr 1 but unaltered activation of the mitogen activated protein kinases ERK 1 and ERK 2 . ^^^ These results indicate that IRS 1 is not necessary for activation of ERK 1 and ERK 2 and that activation of ERK 1 and ERK 2 is not sufficient for IGF 1 stimulated activation of c fos and egr 1 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Antioxidants as well as oxidants activate c fos via Ras dependent activation of extracellular signal regulated kinase 2 and Elk 1 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Recently , H2O2 has been reported to stimulate the activity of the mitogen activated protein kinases ( MAPKs ) ERK and JNK , and the expression of the proto oncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Our data suggest that one mechanism of somatostatin action involves inhibition of ERK activity , Elk 1 phosphorylation and transcriptional activation , and ultimately c fos gene transcription . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Phosphorylation of the guanine nucleotide exchange protein p 170 son of sevenless further suggested a receptor mediated activation of the ERK pathway . c Fos and c Jun expression , downstream targets of ERK and JNK , was dramatically increased in cultured tissue compared with uncultured tissue . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Gastrin induction of ERK 2 activity also resulted in a threefold increase in the transcriptional activity of Elk 1 , a factor known to bind to the c fos SRE and to be phosphorylated and activated by ERK 2 . ^^^ Our data lead us to conclude that the trophic actions of gastrin are mediated by ERK 2 induced c fos gene expression via PKC dependent and independent pathways . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The expression of c fos , c jun and cyclin D 1 , which are downstream of ERK in the mitogenic pathway were stimulated by thrombin but this stimulation was not affected by ceramide or dihydroceramide . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
However , Cd2+ did lead to a sustained activation of the Erk family mitogen activated protein kinases ( MAPK ) that correlated with induction of c fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Requirements of focal adhesions and calcium fluxes for interleukin 1 induced ERK kinase activation and c fos expression in fibroblasts . ^^^ Treatment of human gingival fibroblasts with IL 1 activated extracellular signal regulated kinases ( ERK ) , c Jun N terminal kinase ( JNK ) , and p 38 kinase activity and induced c fos expression in a dose and time dependent fashion . ^^^ Plating cells on poly L lysine prevented focal adhesion formation , eliminated IL 1 induced calcium influx , abolished ERK stimulation , and blocked c fos expression . ^^^ Cells in suspension and hence with no suitable substratum for focal adhesion formation also showed no ERK activation or enhanced c fos expression in response to IL 1 . ^^^ Calcium depletion abolished IL 1 induced calcium uptake , ERK activation , and c fos expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Microinjection of antibodies against Fyn and Yes blocked angiotensin 2 induced DNA synthesis and c Fos expression in WB cells , indicating an obligatory involvement of these tyrosine kinases in the activation of the ERK cascade by angiotensin 2 . ^^^ Finally , substantial reduction of the angiotensin 2 stimulated activation of Fyn , Raf 1 , ERK , and expression of c Fos by pertussis toxin pretreatment argues that G proteins of the Gi family as well as the Gq family are involved in angiotensin 2 mediated mitogenic pathways in WB cells . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
AMP enhances CSF 1 induced ERK activity and c fos mRNA expression via a MEK dependent and Ras independent mechanism in macrophages . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Treatment with HNE resulted in activation of extracellular signal regulated protein kinases ERK 1 and ERK 2 , induction of c fos and c jun protein expression , and an increase in transcription factor AP 1 DNA binding activity . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Increased c fos mRNA levels required Ca2+ influx but not the cyclic AMP or extracellular signal regulated kinase ( ERK 1 / 2 ) signaling pathways , both of which are activated when fibroblasts contract stressed collagen matrices . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
OT stimulated c fos expression was also mediated by ERK 2 phosphorylation . ^^^ The ERK c fos pathway has been shown to be associated with cell proliferation , but OT had no effect on [ 3H ] thymidine uptake by CHO OTR cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
JNK and ERK activations were followed by a 3 . 9 fold increase in arterial AP 1 DNA binding activity , which contained c Jun and c Fos proteins . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Exposure of these cells to EGF resulted in increased expression and phosphorylation of the EGF receptor ( EGF R ) , increased ERK 2 activity and phosphorylation , and increased c fos protein levels . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Evidence is presented that stimulation of c fos transcription by MC involves a signal transduction pathway , which includes activation of the small G protein Ras , Raf 1 kinase , and the mitogen activated protein ( MAP ) kinases , ERK 1 and ERK 2 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In the present study , we report the involvement of epidermal growth factor receptor ( EGF R ) in Ang 2 induced extracellular signal regulated kinase ( ERK ) activation , c fos gene expression , and DNA synthesis in cardiac fibroblasts . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
ANG 2 caused no detectable increase in ERK activity or in c fos mRNA abundance in ARVM but increased ERK activity within 5 min in CMEC and increased c fos mRNA levels . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We show that a transient activation of extracellular signal regulated kinase ( ERK ) proteins ( detected by immunocytochemistry with an anti active antibody ) is spatially coincident with the onset of IEG induction [ c fos , zif 268 , and map kinase phosphatase 1 ( MKP 1 ) detected by in situ hybridization ] in the striatum , bilaterally . ^^^ The role of the ERK signaling cascade in gene regulation was confirmed after intrastriatal and unilateral injection of the specific ERK inhibitor PD 98059 , which completely abolished c fos , zif 268 , and MKP 1 mRNA induction in the injected side . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The contribution of the Ras / mitogen activated protein kinase kinase ( MEK ) / extracellular signal regulated kinase ( ERK ) pathway to Elk 1 mediated transcriptional activation of the c fos SRE in response to GH was examined . ^^^ Wortmannin , which inhibited GH induced ERK phosphorylation , also attenuated transcriptional activation of c fos by GH . ^^^ Taken together , these data suggest that GH dependent activation of the Ras / MEK / ERK pathway and subsequent serine phosphorylation of Elk 1 contribute to GH stimulated c fos expression through the SRE . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Both IL 8 and GROalpha activate ERK and MEK through R 2 , whereas MIP 1alpha , a beta chemokine , does not activate these kinases through either of these receptors . ( b ) ERK activation is inhibited by pertussis toxin and MEK 1 inhibitor . ( c ) ERK activation is independent of the upstream mediators Ras and Raf 1 . ( d ) The downstream effects of ERK activation result in an increase of c fos mRNA through both R 1 and R 2 receptors . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
These data indicate that ERK functions as a common component in two signaling pathways ( ERK / Elk 1 and ERK / ? / CREB ) converging on the c fos promoter in postmitotic neuronal cells and that CaM Ks act as positive regulators of these pathways . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In response to oxidant stress , the cardiovascular system is known to express a number of genes , which could occur owing to the participation of mitogen activated protein kinases such as MAPKs , ERK and JNK ( SAPK ) followed by stimulation of at least two well defined transcription factors NF KB and AP 1 ( c Fos and c Jun ) . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In these transfectants , ACTH induced c FOS protein expression , but did not activate the ERK isoforms of MAP Kinase and did not stimulate DNA synthesis . ^^^ Apparently , the ACTH R in Balb 3T3 cells induces the c fos gene by a pathway independent of cAMP / protein kinase A and ERK / MAP Kinase . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Thus , in a physiological context the Ras Raf MEK ERK pathway , but not RhoA , is required for LPA stimulated c Fos expression in Rat 1 cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Ectopic expression of the wild type APS , but not C terminal truncated APS , in NIH3T3 fibroblasts suppressed PDGF induced MAP kinase ( Erk 2 ) activation , c fos and c myc induction as well as cell proliferation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
To understand the role of redox sensitive mechanisms in vascular smooth muscle cell ( VSMC ) growth , we have studied the effect of N acetylcysteine ( NAC ) , a thiol antioxidant , and diphenyleneiodonium ( DPI ) , a potent NADH / NADPH oxidase inhibitor , on serum , platelet derived growth factor BB , and thrombin induced ERK 2 , JNK 1 , and p 38 mitogen activated protein ( MAP ) kinase activation ; c Fos , c Jun , and JunB expression ; and DNA synthesis . ^^^ On the contrary , these compounds had differential effects on agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation and c Fos , c Jun , and JunB expression . ^^^ NAC inhibited agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation and c Fos , c Jun , and JunB expression except for platelet derived growth factor BB induced ERK 2 activation . ^^^ Together , these results strongly suggest a role for redox sensitive mechanisms in agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation ; c Fos , c Jun , and JunB expression ; AP 1 activity ; and DNA synthesis in VSMC . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Translocation of MAP ( Erk 1 and 2 ) kinases to cell nuclei and activation of c fos gene during healing of experimental gastric ulcers . ^^^ We examined localization of extracellular signal regulated kinases ( Erk ) 1 and 2 , and c fos mRNA expression in normal and ulcerated gastric mucosa in rats at 1 , 3 and 7 days after gastric ulcer induction . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Specific inhibition of MEK leads to suppression of ERK activation , marked reduction in steady state levels of c Fos , and inhibition of cell movement and MMP 9 production . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
A number of cellular functions of RSK have been proposed . ( 1 ) Regulation of gene expression via association and phosphorylation of transcriptional regulators including c Fos , estrogen receptor , NFkappaB / IkappaB alpha , cAMP response element binding protein ( CREB ) and CREB binding protein ; ( 2 ) RSK is implicated in cell cycle regulation in Xenopus laevis oocytes by inactivation of the Myt 1 protein kinase leading to activation of the cyclin dependent kinase p34cdc2 ; ( 3 ) RSK may regulate protein synthesis by phosphorylation of polyribosomal proteins and glycogen synthase kinase 3 ; and ( 4 ) RSK phosphorylates the Ras GTP / GDP exchange factor , Sos leading to feedback inhibition of the Ras ERK pathway . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Here , we report that the EGF receptor kinase inhibitor AG 1478 and the ERK kinase inhibitor PD 98059 markedly inhibited angiotensin 2 induced c Fos expression and protein synthesis but not c Jun expression in these cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Blockade of calcium influx through nifedipine sensitive voltage gated calcium channels reduced buserelin induced activation of extracellular signal regulated kinase ( ERK ) and c Fos while activation of c Jun N terminal kinase and c Jun was unaffected . ^^^ Direct activation of alphaT 3 1 cell L type calcium channels with the agonist Bay K 8644 resulted in phosphorylation of ERK and induction of c Fos . ^^^ These observations suggest that calcium influx through L type channels is required for GnRH induced activation of ERK and c Fos and that the influence of calcium lies downstream of protein kinase C . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We examined the mechanisms of interaction of crocidolite asbestos fibers with the epidermal growth factor ( EGF ) receptor ( EGFR ) and the role of the EGFR extracellular signal regulated kinase ( ERK ) signaling pathway in early response protooncogene ( c fos / c jun ) expression and apoptosis induced by asbestos in rat pleural mesothelial ( RPM ) cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
A much lowered degree of Shc phosphorylation , Ras and Erk 2 activation and c fos induction was seen in the Y568F mutant , while in the Y570F mutant these responses were less affected . ^^^ In a mutant receptor with both Tyr 568 and Tyr 570 mutated to phenylalanine residues , no phosphorylation of Shc and no activation of Ras and Erk 2 was seen in response to stem cell factor stimulation , very weak induction of c fos was seen and the mitogenic response was severely depressed . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Isolated DH PH 2 module activates c Jun NH ( 2 ) terminal kinase and the c fos promoter in response to LPA , providing the basis for an ERK independent mechanism . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Novel membrane targeted ERK 1 and ERK 2 chimeras which act as dominant negative , isotype specific mitogen activated protein kinase inhibitors of Ras Raf mediated transcriptional activation of c fos in NIH 3T3 cells . ^^^ The inhibition of the Ras mediated c fos induction by ERK 2 CAAX can in part be rescued by coexpression of a wild type ERK 2 but not by wild type ERK 1 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Activation of p 38 MAP kinase and ERK are required for ultraviolet B induced c fos gene expression in human keratinocytes . ^^^ The effects of p 38 MAP kinase and ERK on UVB induced c fos gene expression were studied in a human keratinocyte cell line , FL 30 . ^^^ UVB significantly increased c fos gene expression at both the transcriptional and protein levels . p 38 and ERK were also significantly activated after UVB irradiation . ^^^ Inhibiting ERK partially abrogated UVB induced c fos transcriptional and protein levels . ^^^ Suppression of both p 38 and ERK not only completely blocked UVB induced c fos expression , but also decreased c fos gene basal expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
JNK and c Jun but not ERK and c Fos are associated with sustained neointima formation after balloon injury . ^^^ Cryocut sections were stained using antibodies directed against c Jun , phosphorylated c Jun , c Fos , c Jun amino terminal kinase ( JNK ) , extracellular signal related kinase ( ERK ) , von Willebrand factor , ki 67 antigen , and alpha actin . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Exposure to 10 microM CdCl ( 2 ) for 8 h caused a prolonged activation of Erk kinase and accumulation of c fos mRNA . ^^^ Inhibition of Erk activation with PD 98059 only partially inhibited c fos induction , indicating that additional pathways are involved . ^^^ All three signals , i . e . , Erk activity , SAPK activity , and c fos mRNA levels in response to Cd ( 2+ ) showed a similar biphasic time course with an initial increase at 15 30 min and then a larger and more prolonged increase several hours later . ^^^ We conclude that Cd ( 2+ ) is a specific inducer of c fos in mesangial cells , probably through activation of both Erk kinase and SAPK pathways . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Point mutations within the consensus MAP kinase binding motif of TFII 1 inhibit its ability to bind ERK and its ability to enhance the c fos promoter . ^^^ In addition , TFII 1 can be phosphorylated in vitro by ERK and mutation of consensus MAP kinase substrate sites at serines 627 and 633 impairs the phosphorylation of TFII 1 by ERK and its activity on the c fos promoter . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In the present study , we have investigated the roles of two mitogen activated protein ( MAP ) kinases , extracellular signal regulated protein kinase ( ERK ) and p 38 MAP kinase ( p 38 kinase ) in calcium and NO induced c fos expression in PC 12 cells . ^^^ This finding indicates that the calmodulin dependent activation of ERK and p 38 kinase is involved in calcium induced c fos expression . ^^^ We also observed that NO dose dependently potentiates not only calcium induced c fos expression but also calcium induced ERK activation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
MEK inhibitor PD inhibited c fos induction by FGF 2 and PDGF BB , suggesting that c fos is the downstream target of ERK pathway . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Pretreatment of THP 1 cells with PD 98059 , an inhibitor of the ERK kinase cascade , abolished bufalin induced c fos and IL 1 beta gene expressions , indicating that the ERK kinase cascade mediates the induction of inflammatory cytokines by bufalin . ^^^ Inhibition of the Na ( + ) / Ca ( 2+ ) exchanger by KB R 7943 and of protein kinase C ( PKC ) by Ro 31 8220 suppressed ERK activation and gene expressions of c fos and IL 1 beta . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In addition , okadaic acid treatment resulted in the activation of ERK 2 ( p 42 MAP kinase ) and the induction of both c Jun and c Fos proteins without activating JNK ( c Jun NH 2 terminal kinase ) . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Activation of the c fos enhancer by the erk MAP kinase pathway through two sequence elements : the c fos AP 1 and p62TCF sites . ^^^ We find here that the FAP 1 site contributes strongly to phorbol ester ( TPA ) and Erk MAP kinase activation of the c fos enhancer and that both the p62TCF and FAP 1 sites are required for effective activation of the enhancer . ^^^ These results suggest a signaling pathway in which Erk MAP kinase activates the c fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF 1 and CREB . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Although induction of c fos by serum is thought to signal through the Erk mitogen activated protein kinase family , Erk activity was decreased more by 1 microgram / ml heparin in A 10 cells than in PAC 1 or ASMC . ^^^ Although Erk is implicated in c fos induction , cells comparatively resistant to heparin still show heparin dependent inhibition of Erk activation , suggesting that other pathways may be more important for heparin resistance . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
At low concentrations , these chemicals may activate the MAPK ( ERK 2 , JNK 1 , p 38 ) leading to gene expression of survival genes ( c Fos , c Jun ) and defensive genes ( Phase 2 detoxifying enzymes ; GST , QR ) resulting in survival and protective mechanisms ( homeostasis response ) . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Recently , several new members of this family have been identified including IRS 3 , IRS 4 , and growth factor receptor binding protein 2 associated binder 1 ( Gab 1 ) . 3T3 cell lines derived from IRS 1 deficient embryos exhibit a 70 80 % reduction in IGF 1 stimulated S phase entry and a parallel decrease in the induction of the immediate early genes c fos and egr 1 but unaltered activation of the mitogen activated protein kinases extracellular signal regulated kinase 1 and extracellular signal regulated kinase 2 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
By elaborately localizing ERK 2 in the nuclei of senescent cells , we could restore c fos transcriptional activity upon growth stimuli , which was repressed in senescent cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Substantial nuclear immunostaining was commonly apparent , indicative of an activated c jun pool , with associations with MAP kinase signalling elements , e . g . , transforming growth factor alpha ( p = 0 . 04 ) , epidermal growth factor receptor ( p = 0 . 08 ) , phosphorylated erk 1 / 2 MAP kinase ( p = 0 . 001 ) and phosphorylated jun kinase ( p = 0 . 05 ) Little association was noted with c fos protein , perhaps indicating alternative AP 1 partners for c jun with a diversity of cellular end points . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Both TPA and NGF induced a sustained activation and nuclear accumulation of ERK that was accompanied by transactivation of a serum response element ( SRE ) driven reporter and of the c fos gene . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
CRE binding studies suggested that the CRE complex consisted of CRE binding protein and EGF ERK dependent recruitment of c Jun c Fos ( AP 1 ) to the CRE . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
GnRH induced induction and activation of the JNK target c Jun was inhibited after chelation of intracellular calcium , whereas induction of c Fos , a known target of ERK , was unaffected . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We furthermore investigated the mechanisms by which LRb controls downstream ERK activation and c fos and SOCS 3 message accumulation . ^^^ Tyr ( 985 ) and ERK activation similarly mediate c fos mRNA accumulation . ^^^ Thus , the two LRb tyrosine residues that are phosphorylated during receptor activation mediate distinct signaling pathways as follows : SHP 2 binding to Tyr ( 985 ) positively regulates the ERK > c fos pathway , and STAT 3 binding to Tyr ( 1138 ) mediates the inhibitory SOCS 3 pathway . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
To dissect the mechanism of these effects , we measured c Jun and c Fos expression , and the activity of c Jun NH 2 terminal kinase ( JNK ) and extracellular signal regulated kinase ( ERK ) in human umbilical vein endothelial cells ( HUVEC ) . ^^^ In addition , PDTC promoted more transient activation in ERK c fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Exposure of mesangial cells to ionic Cd ( 2+ ) induces the proto oncogene c fos , while activating both Erk and stress activated protein kinase ( SAPK ) MAP kinase pathways . ^^^ While we have previously used a pharmacological inhibitor of Erk activation to implicate involvement of this pathway in the induction of c fos by Cd ( 2+ ) , the consequences of SAPK activation remained unknown . ^^^ However , inhibition of Erk and SAPK pathways together abrogates the increase , suggesting that these pathways act in concert in the induction of c fos by this toxic metal . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
To determine if CREB and mitogen activated protein kinases ( MAPKs ) are involved in the regulation of c fos mRNA expression by LPS and CHX , Western blot was carried out using the phosphorylated form of antibodies against ERK , JNK , p 38 , and CREB . ^^^ Our results suggest that the phosphorylation of ERK , p 38 , and CREB may be involved in the regulation of synergistic c fos mRNA expression induced by LPS plus CHX in C 6 rat glioma cells . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Cross linking of cell surface E selectin with Abs , as a mimic of multivalent ligand engagement , strongly stimulated MAPK / extracellular signal related kinase ( ERK ) kinase ( MEK ) dependent MAPK activation and concomitant up regulation of mRNA for c fos , an immediate early response gene , whereas Ab cross linking of HLA class 1 molecules ( present at comparable density ) failed to do so . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
GAL 4 Elk1 studies revealed that DEX suppressed TGF beta induced ERK activation which led to c fos gene expression followed by increase in AP 1 complex formation , whereas the Smad pathway was not involved in DEX dependent negative regulation of AP 1 in a reporter assay that requires FAST 1 Smad2 for the activation . ^^^ DEX also eliminated TGF beta induced c fos mRNA expression and ERK activation in Northern analysis and in vitro kinase assay , respectively . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The AngII induced EGF receptor transactivation leads to activation of downstream signaling molecules including Ras , ERK , c fos , Akt / protein kinase B , and p 70 S6 kinase . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Intravenous administration of leukaemia inhibitory factor ( LIF ) induced tyrosine phosphorylation of STAT 3 and ERK 1 / 2 and expression of c fos and beta MHC mRNAs in wild type littermates ' ( WT ) hearts . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The gene expression was preceded by 1 ) induction of AP 1 components c fos and c jun and 2 ) phosphorylation of extracellular signal regulated kinase ( ERK ) , p 38 mitogen activated protein ( MAP ) kinase , and c Jun NH ( 2 ) terminal kinase ( JNK ) , the upstream inducers / activators of AP 1 . ^^^ Suppression of ERK by PD 098059 abrogated induction of c fos and c jun , and the p 38 MAP kinase inhibitor SB 203580 attenuated c fos expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Because SL 327 antagonized cocaine induced c fos expression and Elk 1 hyperphosphorylation , we suggest that the ERK intracellular signaling cascade is also involved in the prime burst of gene expression underlying long term behavioral changes induced by cocaine . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
To study the role of extracellular signal regulated kinase ( ERK ) cascade and the small GTP ase proteins in the activation of the c fos promoter by angiotensin 2 ( AII ) , transient transfection experiments were performed in CHO cells stably expressing the rat AT ( 1A ) receptor . ^^^ In this system AII activated ERK in 1 min and also increased the transcriptional activity of the c fos promoter luciferase reporter gene construct . ^^^ These results suggest that AII activates the transcription of the c fos through the Ras Raf ERK cascade . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Serum stimulated c Fos expression is dependent on MAPK / Erk activity because the MEK inhibitor PD 98059 suppresses Erk activity and c Fos expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The mitogenic signal transmission pathways leading to c fos activation upon 10 infection were apparently mediated by the protein kinases MEK , ERK , and PKA . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Cells differed in their susceptibility towards inhibition by genistein of phorbol ester induced proto oncogene c fos levels , transcription factor activator protein 1 ( AP 1 ) activity and extracellular signal regulated kinase ( ERK ) activity . ^^^ The results suggest that induction of apoptosis , G 2 cell cycle arrest and inhibition of c fos expression , AP 1 transactivation and ERK phosphorylation may contribute to the growth inhibitory effect of genistein in some breast cell types , but none of these effects of genistein constitutes a generic mode of growth arresting action . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
However , we find that T kininogen expressing cell lines are still capable of responding to growth factors present in the serum , both by activating the ERK pathway and by expressing early genes , such as c Fos and c Jun . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Such constitutive ERK and JNK activation as a consequence of continued HBx expression also led to sustained stimulation of further downstream events , such as increased levels of c Jun and c Fos proteins along with the persistent induction of activator protein 1 binding activity . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In intact cells , the ERK 2 mutants were functionally active in phosphorylating Elk 1 and RSK 1 and activating the c fos promoter . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
These results indicate that heparin and HS inhibited ET 1 induced ERK activation , resulting in suppression of Elk 1 phosphorylation , and lead to inhibition of c fos gene expression through SRF independent manner . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Phosphorylation of ERK and c fos mRNA expression were determined by Western and Northern blot analyses , respectively . ^^^ PPAR gamma agonists 15 d PGJ 2 and thiazolidinediones such as pioglitazone and troglitazone elicited rapid activation of ERK within 15 min and induced c fos mRNA expression within 30 min , whereas the PPAR alpha agonist bezafibrate failed to activate ERK . 15 d PGJ 2 induced expression of c fos mRNA was blocked by PD 98059 or U 0126 , two ERK kinase inhibitors , suggesting that the MEK / ERK pathway mediates 15 d PGJ 2 induced c fos gene expression . ^^^ Furthermore , pretreatment with wortmannin , an inhibitor of phosphatidylinositol 3 ( PI 3 ) kinase , inhibited 15 d PGJ 2 induced ERK activation and c fos mRNA expression , suggesting that PI 3 kinase is involved in the process . ^^^ Taken together , our findings show that 15 d PGJ 2 and thiazolidinediones activate the MEK / ERK pathway through PI 3 kinase and lead to c fos mRNA expression and DNA synthesis . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Potential nuclear targets of TNFalpha activated ERK 1 / 2 include the transcription factors Ets 1 , Egr 1 , and c fos , which are known to regulate cellular growth , differentiation , and migration . ^^^ The aim of this study was to investigate the expression of the transcription factors Ets 1 , Egr 1 and c fos in different types of vascular lesions , their regulation by TNFalpha and the role of ERK 1 / 2 in these signaling events . ^^^ Atherosclerotic lesions from fructose fed LDL receptor deficient mice and neointimal lesions from rat aortae 2 weeks post balloon injury demonstrated the presence and colocalization of TNFalpha , phosphorylated and activated ERK 1 / 2 , and transcription factors Ets 1 , Egr 1 and c fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
ET 1 induced transcription of the immediate early gene c fos requires the concomitant activation of both the PKC / ERK and p38MAPK dependent pathways , because inhibitors of either pathway block the ET 1 induced increase of c fos mRNA . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Treatment with EGCG inhibited phosphorylation of the EGFR , signal transducer and activator of transcription 3 ( Stat 3 ) , and extracellular regulated kinase ( ERK ) proteins and also inhibited basal and transforming growth factor alpha stimulated c fos and cyclin D 1 promoter activity . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Despite activation of EGF receptor ERK signaling pathway , epithelial proliferation is impaired in portal hypertensive gastric mucosa : relevance of MKP 1 , c fos , c myc , and cyclin D 1 expression . ^^^ In gastric mucosa of PHT and sham operated ( SO ) rats we studied : ( 1 ) EGF R mRNA and protein expression as well as phosphorylation and membrane protein tyrosine kinase ( PTK ) activity ; ( 2 ) ERK 2 phosphorylation and activity ; ( 3 ) MKP 1 mRNA and protein ; ( 4 ) c fos , c myc and cyclin D 1 mRNAs , and gastric epithelial proliferation . ^^^ These results suggest that in PHT gastric mucosa , ERK activation is mediated through EGF R upregulation , but the gastric epithelial proliferation is impaired , possibly by MKP 1 overexpression , leading to reduction of c fos , c myc and cyclin D1 . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Another signaling cascade by which GSA activates VSMCs is the ERK > c Fos > AP 1 pathway , which may lead to stimulation of cell proliferation and migration . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Downregulation of c fos gene transcription in cells transformed by E1A and cHa ras oncogenes : a role of sustained activation of MAP / ERK kinase cascade and of inactive chromatin structure at c fos promoter . ^^^ To elucidate the mechanisms of c fos downregulation in E1A+cHa ras transformants , we studied the levels of activity of ERK , JNK / SAPK and p 38 kinases and phosphorylation state of Elk 1 transcription factor involved in regulation of c fos gene . ^^^ In attempt to determine how serum caused the stimulatory effect , we found that PD 98059 , an inhibitor of MEK / ERK kinase cascade , completely suppressed serum induced c fos transcription both in REF and E1A+cHa ras cells , implicating the ERK as primary kinase for c fos transcription in these cells . ^^^ The refractory state of c fos in E1A+cHa ras cells is likely a consequence of Ras induced sustained activation of MAPK ( ERK ) cascade and persistent phosphorylation of TCF ( Elk 1 ) bound to SRE . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Nuclear activated extracellular signal regulated kinase ( ERK ) was rapidly dephosphorylated , with consequent short term activation of the Elk 1 transcription factor and expression of the c fos gene . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In conclusion , c fos promoter activation and transcription were enhanced through the activation of extracellular signal regulated kinases ( ERK ) / mitogen activated protein kinase ( MAPK ) cascade in gastric cancer cells when cocultured with H . pylori possessing intact cag PAI . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Inactivation of EGFR kinase with selective inhibitors significantly reduces PGE 2 induced ERK 2 activation , c fos mRNA expression and cell proliferation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Nuclear accumulation of activated ERK is associated with transient , peaking at 30 min , induction of c Fos and sustained , observed at 24 48 h , decrease of tropoelastin mRNA levels in NE challenged cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The MEK inhibitor PD 98059 produced near complete ( 97 98 % ) inhibition of ERK phosphorylation , whereas inhibition of c Fos , c Jun , HB EGF , AR , and VEGF mRNA by this compound was incomplete ( 41 65 % ) . ^^^ PD 98059 was significantly more effective than either PD 158780 or BB 2516 as an inhibitor of ERK phosphorylation and of the rapid rise in c Fos and c Jun mRNA expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Stimulation of DNA synthesis , activation of mitogen activated protein kinase ERK 2 and nuclear accumulation of c fos in human aortic smooth muscle cells by ketamine . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We have shown previously that GnRH activates ERK and induces the c fos and LH beta genes in these cells . ^^^ Signaling via the G ( 1 ) subfamily of G proteins was excluded , as neither ERK activation nor c Fos and LH beta induction was impaired by treatment with pertussis toxin or a cell permeable peptide that sequesters G beta gamma subunits . ^^^ A cell permeable peptide that uncouples G alpha ( s ) from receptors was also able to inhibit ERK , c Fos , and LH beta , indicating that both G ( q / 11 ) and G ( s ) proteins are involved in signaling . ^^^ Artificial elevation of cAMP with forskolin activated ERK and caused a partial induction of c Fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Incubation of OKP cells in acid media increased ERK activity and c fos expression , but did not increase JNK activity . ^^^ Expression of c srcK295M did not affect ERK or c fos activation by acid incubation . ^^^ CONCLUSIONS : These studies suggest that acidosis activates c Src and MEK / ERK / c fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Finally , blockade of ERK 1 / 2 phosphorylation with the mitogen activated protein kinase ( MEK ) 1 / 2 inhibitor SL 327 blocked alcohol induced c Fos expression , suggesting that alcohol induces c Fos in Edinger Westphal neurons through activation of the MEK1 / 2 ERK1 / 2 Stat 3 pathway . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In addition , apigenin resulted in a significant inhibition of the FBS induced phosphorylation of extracellular signal regulated kinase 1 / 2 ( ERK 1 / 2 ) and expression of c fos mRNA . ^^^ These results suggest that apigenin inhibits FBS and PDGF BB induced VSMC proliferation , and its activity may be mediated , at least in part , by down regulation of ERK 1 / 2 and its downstream c fos mRNA . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We show that the immediate early gene product c Fos functions as a sensor for ERK 1 ( extracellular signal regulated kinase 1 ) and ERK 2 signal duration . ^^^ When ERK activation is transient , its activity declines before the c Fos protein accumulates , and under these conditions c Fos is unstable . ^^^ However , when ERK signalling is sustained , c Fos is phosphorylated by still active ERK and RSK ( 90K ribosomal S 6 kinase ) . ^^^ Carboxy terminal phosphorylation stabilizes c Fos and primes additional phosphorylation by exposing a docking site for ERK , termed the FXFP ( DEF ) domain . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Activation of c fos expression is significantly inhibited in TTA treated cells but the enzymatic activation of mitogen activated protein kinase ( ERK ) is not affected . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The use of selective inhibitors for the ERK pathway ( PD 98059 and U 0126 ) , p 38 ( SB 203580 ) , and JNK pathway ( curcumin ) demonstrated that activation of all three MAPK signaling pathways was necessary for optimal stretch induced c fos expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The ERK pathway also modulates the expression of genes via phosphorylation of the transcription factor Elk 1 that controls the production of the c Fos transcription factor . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The Raf 1 / B Raf double deficient DT 40 cells show an almost complete block both in ERK activation and in the induction of the immediate early gene products c Fos and Egr 1 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Due to the presence of IP 3 receptors both in the SR ( A band region ) and in the nuclear envelope , these two events appear to be related ; 3 ) Phosphorylation of mitogen activated kinases ( ERK 1 / 2 ) and of the transcription factor CREB ( 30 s 10 min ) , as well as expression of the early genes c fos , c jun and egr 1 mRNA ( 5 15 min ) . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Deletion of the Gab 1 PH domain significantly attenuates GH induced ERK activation and trans activation of a c fos enhancer driven reporter construct compared with wild type Gab 1 in this system . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Specifically , our data suggest that , in keratinocytes derived from initiated mouse skin , ERK plays an important role in transmitting palytoxin stimulated signals to three downstream targets that are likely to affect carcinogenesis : c Fos , AP 1 , and MMP 13 . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The c Fos and extracellular signal regulated protein kinase ( ERK ) protein expression levels were examined in SGC 7901 cells and carcinoma tissue by immunohistochemistry and immunoblotting . ^^^ The c Fos and ERK 1 / ERK 2 proteins were decreased in the nude mice carcinoma tissues and SGC 7901 gastric carcinoma cells which treated with octreotide by immunohistochemistry or immunoblotting analysis . ^^^ CONCLUSION : Octreotide inhibits not only ERK 1 / ERK 2 and c Fos expressions but also AP 1 binding activity , which result in inhibition to proliferation of gastric carcinoma cell . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Differential response of two subdivisions of lateral amygdala to aversive conditioning as revealed by c Fos and P ERK mapping . ^^^ Next , immunocytochemical mapping of phosphorylated extracellular signal regulated kinase ( P ERK ) and c Fos transcription factor protein was performed , and the expression pattern of both markers within the dorsal nucleus of lateral amygdala ( LaD ) was analyzed . ^^^ As immunocytochemical studies revealed , aversive training induced ERK phosphorylation and c Fos expression specifically in ventral but not dorsal tip of LaD . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
After pre treatment of cells for 20 min , curcumin ( 40 microM ) inhibited EGF stimulated phosphorylation of the EGFR in MDA MB 468 cells and phosphorylation of extracellular signal regulated kinases ( ERKs ) 1 and 2 , as well as ERK activity and levels of nuclear c fos in both cell lines . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We now describe the calcium dependence of P CREB and P ERK induction and of the increases in mRNA of the early genes c fos , c jun , and egr 1 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We found that induction of both c fos and c jun by arsenite can be substantially inhibited by the MEK selective inhibitor U 0126 , suggesting that the ERK pathway is critically involved in their up regulation . ^^^ Finally , chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation / acetylation of histone H 3 associated with the c fos and c jun genes through an ERK dependent pathway . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Thus , while c Fms and alpha ( 5 ) beta ( 3 ) collaborate in the osteoclastogenic process via shared activation of the ERK / c Fos signaling pathway , the integrin is essential for matrix degradation . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Epidermal growth factor induces c fos and c jun mRNA via Raf 1 / MEK1 / ERK dependent and independent pathways in bovine luteal cells . ^^^ The present study was designed to examine in bovine luteal cells ( 1 ) activation of the extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase ( MAPK ) signaling cascade ( Raf / MEK / ERK ) by EGF ; ( 2 ) mRNA expression of AP 1 transcription factors , i . e . c fos and c jun , in response to EGF ; and ( 3 ) the role of ERK in EGF induced expression of c fos and c jun mRNA . ^^^ However , blocking EGF induced ERK activation by pretreatment with PD 098059 only partially attenuated EGF induced c fos and c jun mRNA expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In conclusion , the activation of conventional PKCs through P2Y2 receptor acts in concert with ERK and PI3K / PKC epsilon pathways to induce c Fos protein and HeLa cell proliferation . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Under conditions where JNK 1 and ERK 2 were activated , BHA also activated transcription factors nuclear factor kappa B ( NF kappaB ) , activated protein 1 ( AP 1 ) , and anti oxidant response element ( ARE ) , leading to induction of genes such as c jun , and c fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Early targets of activated ERK , c Jun and c Fos , were elevated during infection , as demonstrated by semiquantitative reverse transcription PCR . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We also examined possible mechanisms by which agrin may modulate neurite outgrowth , analyzing ERK phosphorylation and c fos phosphorylation . ^^^ These studies indicate that agrin augments a transient early phosphorylation of ERK in the presence of FGF 2 , and augments and sustains FGF 2 mediated increases in c fos phosphorylation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
RESULTS : Analysing the signalling events following stimulation of mouse embryonic stem cells with serum and lysophosphatidic acid , we show that the extracellular signal regulated kinase ( ERK ) pathway is involved in mediating c fos induction . ^^^ We demonstrate that the ERK activated kinase MSK 1 is required for full c fos promoter activation , as well as for the phosphorylation of cAMP responsive element ( CRE ) binding proteins . ^^^ We propose that MSK 1 contributes to ERK mediated c fos promoter activation by targeting CRE binding proteins . ^^^ CONCLUSION : These results show that MSK 1 is an important ERK activated mediator of mitogen stimulated c fos induction . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We have studied phospholipase D ( PLD ) activation in relation to protein kinase C ( PKC ) and the involvement of PLD in extracellularly regulated kinase 1 ( MAPK ) ( ERK 1 ) activation and c fos mRNA expression in C3H / 10T1 / 2 ( Cl 8 ) fibroblasts . ^^^ Formation of phosphatidylbutanol ( PtdBut ) at the expense of phosphatidic acid ( PtdH ) in the presence of n butanol inhibited ERK 1 activation and c fos mRNA expression in PDGF BB treated Cl 8 cells . ^^^ These results indicate ( 1 ) a role of a functional interaction between the RACK 1 scaffolding protein and a alphaPKC PLD complex for achieving full PLD activity in PDGF BB and PMA stimulated Cl 8 cells ; ( 2 ) PLD mediated PtdH formation is needed for optimal ERK 1 activation by PDGF BB and maximal increase in c fos mRNA expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Our results suggest that the increased expression of the c Fos , c Jun , and phosphorylation of ERK , JNK 1 , and CaMK 2 proteins may play important roles in the memory impairment and the cell death in CA 3 region of the hippocampus induced by i . c . v . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Cholesterol depletion also significantly attenuated GnRH but not phorbol ester mediated activation of extracellular signal related kinase ( ERK ) and c fos gene induction . ^^^ Raft localization and GnRHR signaling to ERK and c Fos were rescued upon repletion of membrane cholesterol . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Using the MEK inhibitor PD 098059 in order to assess the role of ERK MAPK in PMA / Io stimulated splenocytes ( SPLC ) , it was determined that IL 2 production and expression of c fos and c jun nuclear protein expression depended on activation of ERK MAPK . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Suppressive effect of taurine on platelet derived growth factor ( PDGF ) BB induced c fos and c jun mRNA expressions through extracellular signal regulated kinase ( ERK ) in mesenchymal cell lines . ^^^ Thus , the inhibitory mechanism of taurine on PDGF induced c fos and c jun mRNA expressions may depend on the p44 / p42 ERK pathway , but not on PDGF beta receptor tyrosine phosphorylation , JNK / SAPK or p 38 MAPK pathway . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Desensitization was observed for activation of ERK and p 38 MAPK and induction of c fos and LHbeta protein expression . ^^^ Activation of individual signaling pathways was able to partially mimic the desensitizing effect of GnRH on ERK , p 38 MAPK , c fos , and LHbeta but not on Gq / 11 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In this study , we show that PDGF regulates AP 1 by stimulating the expression and function of c Fos through extracellular signal regulated kinase ( ERK ) . ^^^ The latter involves the direct phosphorylation by ERK of multiple residues in the carboxyl terminal transactivation domain of c Fos , which results in its increased transcriptional activity . ^^^ Interestingly , the phosphorylation of c Fos by ERK was required for the ability of PDGF and serum to stimulate the activity of c Fos as well as AP 1 dependent transcription . ^^^ Furthermore , we provide evidence that the ERK dependent activation of c Fos is an integral component of the mitogenic pathway by which PDGF regulates normal and aberrant cell growth . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Hypertrophic stimuli transiently induced AP 1 dimers containing c Fos , and this was dependent on the ERK mitogen activated protein kinase pathway and coincided with the activation of AP 1 mediated transcription and the induction of GLUT 1 in cardiac myocytes . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Previous studies showed that palytoxin simulates an ERK dependent selective increase in the c Fos content of AP 1 complexes that bind to the promoter of the MMP 13 gene . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Interestingly , co administration of nicotine and Ang 2 at lower doses , which did not affect cell growth , induced DNA synthesis and c fos expression accompanied by enhancement of ERK , STAT , and p38MAPK activity . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In the hypothalamic arcuate nucleus , phosphorylation of ERK significantly increased during fasting , spatially coincident with phosphorylation of cAMP response element binding protein ( CREB ) , induction of c Fos , and expression of neuropeptide Y ( NPY ) . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Expression of the Gab 2 Tyr 614 > Phe ( Y614F ) mutant , defective in SHP 2 association , prevents ERK ( extracellular signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c fos SRE ( serum response element ) , indicating that interaction of SHP 2 with Gab 2 is required for ERK activation in response to IL 2 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Extracellular signal regulated kinase ( ERK ) and p 38 were involved in the c fos mRNA expression , and c Jun NH ( 2 ) terminal kinase ( JNK ) was involved in the c jun mRNA expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Subsequently , curcumin inhibits the activation of NF ( nucleor factor ) kappaB and the expressions of oncogenes including c jun , c fos , c myc , NIK , MAPKs , ERK , ELK , PI3K , Akt , CDKs and iNOS . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Given the evidence for abnormalities in schizophrenia in a neural circuit involving the cerebellum and thalamus , the present study was conducted to examine the expression of MAP kinases extracellular signal regulated kinase ( ERK ) , c Jun N terminal kinase ( JNK ) and p 38 , as well as immediate early genes fos ( c fos and fos B ) and jun ( c jun , jun B and jun D ) using a Western blot analysis and reverse transcription polymerase chain reaction ( RT PCR ) in postmortem thalamus from schizophrenic and control subjects . ^^^ There were significant increase in ERK 2 , c fos and c jun protein and mRNA levels in thalamus of patients with schizophrenia relative to controls . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
AR also strongly and quickly stimulated Akt and ERK phosphorylation and c fos and c jun expression in an EGF receptor dependent manner . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In addition to the induction of cell proliferation and migration , bradykinin ( BK ) can increase c fos mRNA expression , activate ERK 1 / 2 and generate reactive oxygen species ( ROS ) in vascular smooth muscle cells ( VSMC ) . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We found several proteins upregulated 24 h after training : extracellular signal regulated kinase ERK 2 , Ca2+ / calmodulin dependent protein kinase 2 alpha ( CaMKIIalpha ) , Syntaxin 1a , c fos and Homer 1a . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Furthermore , ERK activated through this PSD 95 / Homer1b / c dependent and Ca2+ independent pathway was able to phosphorylate the two key transcription factors Elk 1 and cAMP response element binding protein , which further leads to facilitation of c Fos expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In RAW 264 . 7 macrophages , ricin induced the activation of ERK , JNK , and p 38 MAPK , the accumulation of mRNA encoding tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 1 , the transcription factors c Fos , c Jun , and EGR 1 , and the appearance of TNF alpha protein in the culture medium . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Three MAPKs , extracellular signal regulated kinase ( ERK ) , p 38 MAPK and c Jun N terminal kinase ( JNK ) , which were simultaneously activated by IL 1beta , mediated subsequent c fos and c jun mRNA expression and DNA binding of AP 1 at different magnitudes . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
While inhibition of JNK mainly prevents expression and phosphorylation of JunD and c Jun , inhibition of the ERK pathway suppresses both phosphorylation and expression of Jun proteins , and expression of c Fos and Fra 1 . ^^^ The importance of AP 1 as a mediator ERK signaling during differentiation is demonstrated by the findings that expression of c fos siRNA and dominant negative AP 1 / c Jun ( bZIP ) downregulate the TPA and ERK induced expression of alpha2beta1 integrin mRNAs and proteins . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The impact of different provocations on ERK translocation and c fos expression in neonatal cultured cardiomyocytes . ] . ^^^ OBJECTIVE : To study the nuclear translocation of extracellular signal regulated kinase ( ERK ) and expression of c fos mRNA under stimulation of AngII as well as the influence on the nuclear translocation of ERK with different interferences in neonatal cultured cardiomyocytes . ^^^ METHODS : ERK in the cytoplasm or nucleus was observed by immunocytochemistry using specific antibody and the expression of c fos was evaluated with RT PCR technique . ^^^ CONCLUSION : The nuclear translocation of ERK might be a precondition for the inducement of c fos expression . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
This is associated with a reduction in levels of transiently induced MEK and ERK phosphorylation and reduced expression of c Fos and cyclin Dl . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Adenoviral expression of a kinase inactive , dominant negative version of PKCdelta impaired GnRH activation of ERK , but not induction of c Fos and LHbeta proteins , indicating that the novel PKCs signal to the ERK cascade . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Cam inhibition using W 7 was sufficient to block GnRH induced reporter gene activity for the c Fos , murine glycoprotein hormone alpha subunit , and MAPK phosphatase ( MKP ) 2 promoters , all shown to require ERK activation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Moreover , inhibition of ERK and JNK by EPA resulted in the decrease of c Fos expression and c Jun phosphorylation / expression induced by UV , respectively , which led to the inhibition of UV induced activator protein 1 DNA binding activity . ^^^ In conclusion , our results demonstrate that EPA can inhibit UV induced MMP 1 expression by inhibiting the MEK1 / ERK / c Fos and SEK1 / JNK / c Jun pathways . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Associated with this odorant specific induction event was activation of extracellular regulated kinase ( ERK ) 1 / 2 that preceded increased c fos expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Intrathecal injection of U 0126 or ERK antisense ODN markedly suppressed the increase of CCI induced pERK , pCREB and c Fos expression in the spinal cord . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Treatment with HNE increased ERK phosphorylation , c Fos protein , JNK phosphorylation , c Jun phosphorylation , and AP 1 binding . ^^^ Whereas inhibiting the ERK pathway with the MEK inhibitor PD 98059 significantly decreased HNE mediated ERK phosphorylation , c Fos protein induction , AP 1 binding , and HO 1 protein induction , inhibition of the ERK pathway had no effect on HNE induced HO 1 mRNA . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Dark pulse suppression of P ERK and c Fos in the hamster suprachiasmatic nuclei . ^^^ The SCN circadian clock is also reset by pulses of dark , but it is unknown if this stimulus alters the activity of ERK , the transcription factor Elk 1 or expression of the immediate early gene c fos in the SCN . ^^^ In constant light , levels of phosphorylated ERK ( P ERK ) showed significant circadian variation in the Syrian hamster SCN , while levels of c Fos or phosphorylated Elk 1 ( P Elk 1 ) did not . ^^^ A 6 h dark pulse beginning at circadian time ( CT ) 8 down regulated expression of P ERK and c Fos , but not P Elk 1 , in the SCN . ^^^ Following termination of the pulse , levels of c Fos increased above time matched control values , while P ERK expression did not . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Immunohistochemical methodology was employed to evaluate the expression levels of pc Jun , c Fos , JNK 2 , p JNK , p ERK and Runx 2 due to alteration in functional load . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Mechanistic studies to determine the potential of deguelin to block a number of established UVB induced molecular events yielded negative results [ including UVB induced AP 1 DNA binding , c fos and TNFalpha mRNA induction , arachidonic acid release and UVB induced phosphorylation of mTOR ( Ser 2448 ) , akt ( Ser 473 ) and erk ( Thr202 / Tyr204 ) ] . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Cells cotransfected with the dominant negative and positive mutants of signaling molecules revealed that the Ras / Raf / extracellular signal regulated kinase ( ERK ) signaling pathway is involved in ET induced c fos gene expression . ^^^ Furthermore , NO directly inhibited ET 1 induced ERK phosphorylation and activation in a cGMP dependent manner , indicating that NO modulates ET 1 induced c fos expression via its inhibitory effect on ERK signaling pathway . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Several MAPK regulated host transcription factors such as c Jun , STAT1alpha , MEF 2 , c Myc , ATF 2 and c Fos were induced early during infection , and ERK inhibition significantly blocked the c Fos , c Jun , c Myc , and STAT1alpha activation in the infected cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Immunohistochemistry demonstrated that the upstream regulators of c Fos and c Jun , ERK MAPK and MAPKp 38 localized to the nuclei of ONH astrocytes in monkeys with experimental glaucoma . ^^^ Taken together , these results demonstrate c Fos and c Jun activation in ONH astrocytes in vivo and in vitro , and that activation of both transcription factors is associated with ERK and MAPKp 38 activation in experimental glaucoma , suggesting that activation of transcription factors may participate in the induction and maintenance of the reactive astrocyte phenotype in glaucomatous optic neuropathy . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
RESULTS : Extracellular regulated kinase ( ERK ) and c Jun NH terminal kinase ( JNK ) phosphorylation , c fos mRNA expression , and activator protein 1 ( AP 1 ) DNA binding activity stimulated by TGF beta 1 were completely suppressed by the ERK kinase ( MEK ) inhibitors . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Among the downstream effectors of ERK examined , we found that Epimedin C selectively decreased the expression of c Fos , but not c Jun . ^^^ Taken together , the molecular mechanisms of anti tumor activity of Epimedin C may be proceeded by the combined effects of the cell cycle blockage via either the inhibition of CDK 2 and CDK 4 activities , with commensurate increase in their inhibitors , p 21 ( Cip 1 ) and p 27 ( Kip 1 ) or negatively modulates the ERK / c Fos / AP 1 signaling pathway . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The patterns of cocaine induced c Fos , JunB and Zif 268 protein expression were investigated , using an immunohistochemical approach , within distinct nuclei of the amygdala , either in the presence or absence of a selective inhibitor of the ERK pathway , SL 327 . ^^^ Additionally , chronic blocking of ERK activation affected cocaine induced c Fos and JunB but not Zif 268 expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Regulation of the transcriptional activity of c Fos by ERK . ^^^ In the case of c Fos , the activation of ERK leads to an increased expression of c fos mRNA . ^^^ In turn , we have recently shown that ERK phosphorylates multiple residues within the carboxylterminal transactivation domain ( TAD ) of c Fos , thus resulting in its increased transcriptional activity . ^^^ However , how ERK dependent phosphorylation regulates c Fos function is still poorly understood . ^^^ Here , we found that Pin 1 binds c Fos through specific pS / T P sites within the c Fos TAD , and that this interaction results in an enhanced transcriptional response of c Fos to polypeptide growth factors that stimulate ERK . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Basic fibroblast growth factor activates ERK and induces c fos in human embryonic stem cell line MizhES 1 . ^^^ To monitor the consequences of ERK activation , we examined expression of the immediate early gene c fos , one downstream target of the MEK1 / ERK pathway . mRNA and protein levels of the c fos gene were increased by bFGF . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
These data indicate that trilinolein inhibits ET 1 induced ERK phosphorylation , JNK phosphorylation , and c fos gene expression via attenuating superoxide production in cardiomyocytes . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Recently , it has been shown that intracerebroventricular ( i . c . v . ) injection of the D 1 DA receptor agonist , SKF 82958 , produces an enhanced locomotor activating effect as well as increased activation of striatal ERK 1 / 2 MAP kinase , CaM kinase 2 , CREB , and c fos in food restricted ( FR ) relative to ad libitum fed ( AL ) rats . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
JNK / ERK MAPKs and their downstream effectors , c Jun and c Fos ( AP 1 ) , are involved in chondroblastic differention / proliferation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In the present studies , the selective dopamine D 4 agonist PD 168077 induces c Fos expression and extracellular signal regulated kinase ( ERK ) phosphorylation in the hypothalamic paraventricular nucleus ( PVN ) , a site known to regulate proerectile activity . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
However , nuclear translocation of phosphorylated Erk and phosphorylation of its nuclear substrate Elk 1 , which activates the c fos promoter , were impaired . ^^^ CONCLUSION : These results suggest that WASP is essential for NF ATp activation , and for nuclear translocation of p Erk , Elk 1 phosphorylation , and c fos gene expression in T cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Our results show that MSK 1 is a major striatal kinase , downstream from ERK , responsible for the phosphorylation of CREB and H 3 and is required specifically for the induction of c Fos and dynorphin as well as for locomotor sensitization . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In this experiment , the roles of Fos , a protein product of immediate early gene c fos , and extracellular signal regulated protein kinase ( ERK ) 1 / 2 , a signal transduction molecule of mitogen activated protein kinase ( MAPK ) family , in these processes were studied in the PVN of the rat following IL 1beta stimulation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
These results suggest that H . hepaticus induces ERK activation by a pathway dependent upon Tpl 2 and p 105 , and that activation of ERK inhibits the expression of IL 12 p 40 by inducing c Fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In contrast treatment with pure compound showed no inhibitory effect on ERK . c fos and c jun mRNA levels were also reduced in PMA stimulated cells on treatment with crude extract and pure compound . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Indeed , the signal transduction pathways involved in adhesion of Saos 2 cells on HA and titanium were confirmed by the sequential expression of alphav and beta 1 integrins , FAK , and ERK genes followed by the expression of c jun and c fos genes for proliferation and alkaline phosphatase gene for differentiation . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Western blot analysis showed that activation of the MEK1 / 2 ( mitogen activated protein kinase kinase 1 / 2 ) , extracellular signal regulated kinase ( ERK ) , and up regulation of early growth response gene ( Egr 1 ) , c Fos and Cyclin D 1 were observed sequentially after mechanic injury in vitro . ^^^ However , berberine significantly attenuated MEK / ERK activation and downstream target ( Egr 1 , c Fos , Cyclin D 1 and PDGF A ) expression after mechanic injury in vitro . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We find that p 38 MAPK blockade restricts pericellular assembly of HA rich matrices and reduces basal as well as mechanical strain induced release of HA . p 38 MAPK blockers potentiated early strain induced increases but restricted sustained increases in MEK / ERK phosphorylation at later times ; c Fos hyperphosphorylation at threonine 325 was found to parallel this p 38 MAPK mediated modulation of ERK activation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
This was associated with reduced extracellular signal regulated kinase ( ERK ) and p 38 phosphorylation and DNA binding of their cotarget c fos in response to T cell receptor activation . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The first involves PKCdelta , ERK phosphorylation and c Fos accumulation , whilst the second requires another PKC isoform that induces the phosphorylation of c Jun . c Fos and c Jun jointly form an active AP 1 complex , which functions to activate the lytic cascade of KSHV . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Induction of IL 10 is dependent on TLR 2 and dectin 1 mediated activation of ERK MAPK via a mechanism independent of the activation protein 1 ( AP 1 ) transcription factor c Fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Moreover , inhibitions of ERK and JNK by 2 ' , 4 ' , 7 THF resulted in the decrease of c Fos expression and c Jun phosphorylation / expression induced by UV , respectively , which led to the inhibition of UV induced AP 1 DNA binding activity . ^^^ In conclusion , our results demonstrate that 2 ' , 4 ' , 7 THF can inhibit UV induced MMP 1 expression by inhibiting the MEK1 / ERK / c Fos and SEK1 / JNK / c Jun pathways . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
This action of 1 MT correlated with an increased phosphorylation of p 38 and ERK MAPKs and sustained activation of the transcription factor c Fos . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The effects of mechanical strains alone and coupled with inhibitors of microfilament and receptor tyrosine kinase ( RTK ) on activation of extracellular signal regulated kinase ( ERK ) , c fos mRNA , and c Fos protein were examined . ^^^ ERK could be activated by mechanical stimuli in 5 min and so could be c fos mRNA and c Fos protein in 30 min . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Pharmacological inhibition of EGFR tyrosine kinase significantly inhibited UVB mediated induction of ERK , p 38 , and JNK MAP kinases , and their effectors , transcription factors c Fos and c Jun . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Inductions of c fos , c myc , and cyclin D 1 and phosphorylation of retinoblastoma protein ( pRb ) were observed after activation of ERK . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
However , no other downstream responses to NGF stimulation ( such as tyrosine phosphorylation of PLC gamma 1 , PI 3 kinase , ERK 1 and ERK 2 , induction of FOS and NGFI A mRNAs , and neurite extension ) were observed in the unresponsive cell lines . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
FGFR 4 activation also fails to elicit detectable signals characteristic of the FGFR 1 response : tyrosine phosphorylation of SHC and extracellular signal related kinase ( ERK ) proteins and induction of fos and tis 11 RNA expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In gel kinase assays indicated the constitutive activation of ERK 1 , which regulates fos synthesis via phosphorylation of p62TCF , but not ERK 2 , in UM SCC 1 cells . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Parasite infection leads to an up regulation of all members of the Jun / Fos family of proteins and surprisingly , this occurs in the absence of any detectable ERK , or p 38 MAP kinase activity . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
As extracellular signal regulated kinase ( Erk ) and stress activated protein kinase / c Jun N terminal kinase ( SAPK / JNK ) phosphorylation may induce Fos and Jun gene transcription and activator protein 1 ( AP 1 ) DNA binding , the activation of Erk 1 , Erk 2 , p 38 , and SAPK / JNK was examined in the nucleus tractus solitarii and neocortex during hypoxia and following administration of MK 801 . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Here we report that coumermycin induced oligomerization of a membrane localized Raf GyrB fusion protein potently activated Erk 1 and Erk 2 , up regulated Fos protein levels , and induced expression of many immediate early response genes . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Co stimulation synergistically activated fos expression and notably led to increased levels of ERK , CREB and EGF receptor phosphorylation , as well as hyperphosphorylation of ternary complex factor . ^^^ Nevertheless , the ERK pathway does not fully account for this synergy , since fos induction was differentially sensitive to the MEK inhibitor U 0126 , indicating that these two agonists signal differently to this immediate early gene . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Activity of extracellular regulated kinases ( ERK ) 1 and 2 and c jun and c fos mRNA levels were significantly elevated in CAPAN 2 cells cultured continuously in serum free medium . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites . ^^^ Drosophila JNK and ERK phosphorylate D Fos with overlapping , but distinct , patterns . ^^^ Analysis of flies expressing phosphorylation site point mutants of D Fos revealed that the transcription factor responds differentially to JNK and ERK signals . ^^^ These results indicate that the distinction between ERK and JNK signals can be made at the level of D Fos , and that different pathway specific phosphorylated forms of the protein can elicit different responses . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We have identified seven ERK related proteins ( `` ERPs ' ' ) , including ERK 2 , that are stably associated in vivo with AP 1 dimers composed of diverse Jun and Fos family proteins . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Furthermore , activation of ERK and Shc , and c fos gene expression were significantly inhibited by AG 1478 but not by cytochalasin D or PP 1 . ^^^ EGFR was Ca ( 2+ ) independently activated and predominantly contributed to Shc / ERK / c fos activation , while Pyk 2 or c Src contributed less to it . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
RA treatment also did not block TPA induced ERK phosphorylation , Jun / Fos family protein expression except for cFos , or DNA binding of the AP 1 complex . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Interestingly , transient Erk activation resulted in altered AP 1 DNA binding activity and the induction of an AP 1 complex that was devoid of Fos protein and consisted of Jun Jun dimers . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root . ^^^ In order to elucidate the dorsal horn responsiveness to noxious stimulation to the peripheral tissue in the neuritis model of the nerve root , we examined extracellular signal regulated kinase ( ERK ) phosphorylation and Fos expression in spinal cord dorsal horn neurons . ^^^ Three or 7 days after surgery , rats were perfused after receiving noxious mechanical stimulation of the plantar surface of the hind paw using a hemoclip , and the L4 / 5 spinal cord was processed for immunohistochemistry with antibodies for phospho ERK and Fos . ^^^ The number of Fos immunoreactive ( Fos LI ) neurons and phospho ERK immunoreactive ( phospho ERK LI ) neurons in the neuritis group after the noxious stimulation significantly increased compared to the sham treated group at 3 and 7 days after surgery . ^^^ The change in number of phospho ERK LI and Fos LI neurons occurred mainly in the superficial dorsal horn . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Double fluorescent staining proved that the phosphorylated ERK 1 / 2 positive cells in the ipsilateral dorsal spinal cord after axotomy predominantly were microglia and small portion was oligodendrocytes , whereas the Fos expression was mainly in neurons . ^^^ Collectively , the present results suggest that both ERK and Fos signal pathways involve the cellular activation in the spinal cord following dorsal rhizotomy , with ERK mainly in microglia and Fos in neurons . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Western blots for AP 1 and its signal mediators Erk and JNK showed that expression of Fos and JNK were decreased by the addition of FZFAT at 300 microg / ml , whereas Erk was not . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
ERK activation at the larval neuromuscular junction coincides with rapid reduction of synaptic Fasciclin 2 ; in soma , nuclear translocation of activated ERK occurs together with increased transcription of the immediate early genes Fos and c / EBP ( CCAAT element binding protein ) . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
In fibroblasts , the expression of immediate early gene ( IEG ) encoded Fos , Jun , Myc , and early growth response gene 1 ( Egr 1 ) transcription factors is significantly extended by sustained extracellular signal regulated kinase 1 and 2 ( ERK 1 and 2 ) signaling . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Acute Delta ( 9 ) tetrahydrocannabinol ( THC ) injection increased ERK pathway ( ERK , pCREB , and c fos ) mostly in the caudate putamen and cerebellum . ^^^ Moreover , chronic THC exposure induced increases in the ERK cascade ( ERK , pCREB , and Fos B ) in the prefrontal cortex and hippocampus , suggesting that different neuronal circuits seem to be involved in the early phase and late phase of exposure . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We show that extracellular signal regulated kinase ( ERK ) activation and c fos induction in the CPu in response to acute cocaine administration is mediated by the D 1 receptor and inhibited by the D 3 receptor . ^^^ Moreover , ERK activation mediates acute cocaine induced expression of Fos family genes , including c fos , fosB and fra 2 . ^^^ Furthermore , such regulation depends on proper ERK activation and c fos function . ^^^ These results suggest that the D 1 and D 3 receptors elicit opposite regulation of target gene expression by regulating ERK activation and c fos induction after acute and chronic cocaine treatment . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
ERK and p 38 MAP kinases , acting through the downstream mitogen and stress activated kinase 1 / 2 ( MSK1 / 2 ) , elicit histone H 3 phosphorylation on a subfraction of nucleosomes including those at Fos and Jun concomitant with gene induction . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
We show that COC conditioned place preference ( CPP ) activates ERK , CREB , Elk 1 , and Fos in the nucleus accumbens core ( AcbC ) but not shell . ^^^ Intra AcbC infusions of U 0126 , an inhibitor of the ERK kinase MEK , prevent both the activation of ERK , CREB , Elk 1 , and Fos and retrieval of COC CPP . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
Compared with nontransgenic controls and singly transgenic mice expressing hAPP or FYN alone , doubly transgenic FYN / hAPP mice had striking depletions of calbindin , Fos , and phosphorylated ERK ( extracellular signal regulated kinase ) , impaired neuronal induction of Arc , and impaired spatial memory retention . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The spinal ERK inhibition or knockdown also reduced morphine withdrawal induced phosphorylation of cAMP response element binding protein ( CREB ) , which is one of the important downstream substrates of ERK pathway , and Fos expression . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
The present findings suggest that tooth pulp driven neurons in the spinal trigeminal nucleus are involved in tooth pulp pain through activation of the intracellular signal transduction pathway that involves earlier ERK phosphorylation and subsequent Fos expression . . ^^^
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
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Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P28482	Pubmed	SVM Score :0.0
NA