| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Activation of AP 1 ( c Fos and c Jun proteins ) and NF kappa B transcription factors were also inhibited . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| HNE did not affect the Ras / ERK pathway , c fos expression , DNA synthesis , or NF kappaB binding . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| By immunohistology , NF kappa B ( p 65 subunit ) and the c Fos subunit of AP 1 were localized primarily in vascular endothelium . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| A c fos antisense oligodeoxynucleotide ( ODN ) inhibited AP 1 , but not NF kappaB , activation after SCI . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The levels of NF kappaB and CREB transcription factors and the proto oncogenes c fos and c myc were also elevated significantly . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| A down regulation of c jun , NF kappaB 1 , Max , Ets 1 , and p 53 mRNA , and an up regulation of c fos mRNA was noticed . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| TNF regulates some of its cellular responses via induction of the transcription factors NF kappa B and AP 1 ( jun / fos ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The involvement of the Ah receptor , Maf , Nrl , Jun , Fos , and NF kappa B in GST induction is discussed . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Jun D , but not of the other Jun or Fos proteins increased by threefold NF kappaB transactivation . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Anti CD 3 fos also fails to effectively activate zeta associated protein of 70 kDa or NF kappaB . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| A number of genes known to be induced following T cell activation and associated with cell growth were increased in the transfectants , including c fos , c myc , c myb , HLA DR , lck , NF kappa B , interleukin 2 and interleukin 2 receptor alpha ( IL 2R alpha ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Both HD lines also constitutively expressed transcripts for c fos and c jun , which are involved in heterodimeric formation of the transcription factor activation protein 1 , as well as for the NF kappa B / KBF1 gene . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The effects were selective because PDTC did not interfere with MHBst and HBx induced activation of the c fos promoter / enhancer , nor with the basal activity of several other reporter genes lacking functional NF kappa B binding motifs . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Although these three different stimuli produce similar levels of induction of the NF kappa B transcription factor , it is reported that they cause differential expression of other cellular activation genes , including c fos and IL 2 . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| N myc transfected neuroblastoma cells were found to be blocked in the activation of both c fos mRNA and the NF kappa B transcription factor by phorbol ester . ^^^ Introduction of a protein kinase C expression vector in N myc transfected neuroblastoma cells restored inducibility of both c fos and NF kappa B by phorbol ester . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The DNA sequences utilized were : the region of the c fos promoter containing the binding site for serum response factor ( SRF ) ; the region of the HIV LTR containing two binding sites for the transcription factor NF kappa B ; the region of the HIV LTR containing three binding sites for the cellular factor sp 1 . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Since the protooncogenes ( c fos , c jun , and c myc ) are immediate early response genes that are implicated in the process of cell proliferation and differentiation , and activation of certain transcription factors , in particular NF kappa B , is associated with the immediate response of the cell to an injury , we propose that 12 ( R ) HETrE ' s mitogenic and angiogenic activities are mediated , in part , via the activation of NF kappa B and expression of these protooncogenes . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Recent studies have demonstrated that the early response genes c jun , Egr 1 , c fos , and NF kappa B are induced following exposure of mammalian cells to ionizing radiation . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Further investigations have proposed that the bony abnormalities seen in Paget ' s disease are due to the effects of the virus on osteoclastic interleukin 6 and c FOS production , possibly via the transcription factor NF kappa B . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Tax activates transcription of viral and cellular genes through specific enhancers : the 21 bp enhancer of human T cell leukemia virus type 1 , the nuclear factor kappa B ( NF kappa B ) binding site of the interleukin 2 receptor alpha gene , and the serum responsive element of c fos . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| These studies demonstrate that NF kappa B augments gene expression mediated by a multimerized c fos serum response element in the presence of C / EBP . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| A transcriptional activator of human T cell leukemia virus type 1 ( HTLV 1 ) activates at least three distinct enhancers : the viral 21 bp enhancer , the NF kappa B binding site of the IL 2R alpha gene and the CArG box of the c fos gene . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Remarkably , we observed that these samples displayed a persistent expression of the c fos protooncogene , associated to an increased AP 1 DNA binding activity , whereas no variations of CREB or NF kB were detected . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| We now demonstrate that the bZIP regions of c Fos and c Jun are capable of physically interacting with NF kappa B p 65 through the Rel homology domain . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The interferon inducible p 202 protein as a modulator of transcription : inhibition of NF kappa B , c Fos , and c Jun activities . ^^^ Furthermore , p 202 binds the NF kappa B p 50 and p 65 and the AP 1 c Fos and c Jun transcription factors in vitro and in vivo . ^^^ NF kappa B , c Fos , and c Jun participate in the transcription of various cellular and viral genes , and thus p 202 can modulate the expression of these genes in response to interferons . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Rat neonatal cardiac myocytes were exposed to H2O2 , and changes in c fos and c jun mRNAs , immunoreactive c Fos and c Jun proteins ( components of AP 1 ) , and immunoreactive p 50 subunit of NF kappa B were determined . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The interferon inducible growth inhibitory p 202 protein : DNA binding properties and identification of a DNA binding domain . p 202 is an interferon inducible protein whose expression in transfected cells inhibits proliferation . p 202 binds to the retinoblastoma tumor suppressor protein in vitro and in vivo and the transcription factors AP 1 c Fos and c Jun , NF kappaB p 50 and p 65 , and inhibits the transcriptional activity of these factors in vivo . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| This latter E 2 has been demonstrated to participate in transcription factor NF kappaB maturation , c fos degradation , and human papilloma virus mediated p 53 degradation in vitro . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Indeed , whereas activation of transcription factors such as NF kappa B and increased expression of immediate early genes such as c fos , c jun , egr 1 , and c myc are induced during compensatory regeneration , such changes are not observed during hyperplasia induced by certain primary mitogens . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Cytochrome P4502E1 and cytochrome P4502B1 / 2B2 catalyzed carbon tetrachloride metabolism : effects on signal transduction as demonstrated by altered immediate early ( c Fos and c Jun ) gene expression and nuclear AP 1 and NF kappa B transcription factor levels . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Two copies of the IRF 1 kappa B site fused to the heterologous c fos promoter conferred induction of a chloramphenicol acetyl transferase ( CAT ) reported gene in response to stimulation of L 929 fibroblasts with various NF kappa B inducers , such as tumor necrosis factor alpha ( TNF alpha ) or phorbol 12 myristate 13 acetate ( PMA ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB p 50 and p 65 , AP 1 c Fos and c Jun , and E2F1 , and inhibits their transcriptional activity . p 202 also binds pRb , the retinoblastoma protein , and if overexpressed it retards cell proliferation . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| We suggest that increased gene expression of NF kappaB and AP 1 binding activity and up regulation of c fos and c jun may play a role in the mechanism of benzene leukemogenesis . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Of the NF kappaB / Rel family members tested , this CD28RE / AP 1 specific complex contains predominantly c Rel , despite the fact that both p 50 and RelA can efficiently bind to the CD28RE . c Fos and c Jun are also found in this CD28RE / AP 1 specific complex . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The cAMP induced NF kappaB complex contained p 50 and RelB ; in co transfection assays , p 50 and RelB transactivated a reporter construct containing the c myb intronic NF kappaB site upstream of a minimal promoter . 8 Br cAMP and forskolin also increased the DNA binding activity of AP 1 complexes containing JunB , JunD and c Fos in MEL cells which could cooperate with NF kappaB . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Constitutive expression c fos , c jun , and NF kappa B mRNA is in nucleated fetal blood cells and up regulation of c fos and c jun with anti CD 3 stimulation . ^^^ We used reverse transcriptase polymerase chain reaction to examine both fetal and term neonatal cord bloods for mRNA expression of three transcription factors implicated in T cell activation : c jun , c fos , and NF kappa B ( p 50 subunit ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Thus , iodide decreases the formation of Mod 1 , an enhancer A complex involving the p 50 subunit of NF kappa B and a c fos family member , fra 2 , which was previously shown to be important in the suppression of class 1 levels by hydrocortisone . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Overexpression of p 202 in transfected cells retards cell proliferation . p 202 modulates the pattern of gene expression by inhibiting the activity of various transcription factors including NF kappaB , c Fos , c Jun , E2F 1 , and p 53 . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Conversely , co transfection of c Fos and c Jun encoding expression vectors potentiated the p65 / NF kappaB mediated transactivation of the VCAM 1 promoter CAT reporter gene . ^^^ In gel mobility supershift assays , the antibodies to c Fos or c Jun inhibited the binding of TNF alpha activated nuclear NF kappaB to the kappaL kappaR , suggesting that both c Fos and c Jun interacted with NF kappaB . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| IL 2 receptor signaling is a complex process involving a large number of molecules : Ras , Rho , PI 3 kinase , PKC , Akt , transcription factors NF AT , and NF kappaB and some target genes such as bcl 2 , c myc , c jun and c fos . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Moreover , overexpression of p 202 in transfected cells inhibits the transcriptional activity of E2Fs ( E2F 1 / DP 1 and E2F 4 / DP 1 ) , p 53 , AP 1 c Fos and c Jun , NF kappaB p 50 and p 65 . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The human UBE2L3 gene encodes the ubiquitin conjugating enzyme UbcH 7 , demonstrated to participate in the ubiquitination of p 53 , c Fos , and NF kappaB in vitro . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| As assessed by gel mobility shift assay , glomerular DNA binding activity of AP 1 containing both c Jun and c Fos and NF kappaB composed of P 50 and P 65 subunits was significantly increased after ATS injection . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Transcript levels for the NF kappaB inhibitor IkappaBalpha and for the activating protein 1 constituents c jun and c fos also increased in response to HA stimulation of tubular cells . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| We showed that serum deprivation and etoposide induced a distinct pattern of regulation of c Fos , c Jun and p 53 protein levels , as well as the differential changes in DNA binding activity of AP 1 and NF kappaB transcription factors . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB ( p 50 and p 65 ) , AP 1 ( c Fos and c Jun ) , E2F 1 , E2F 4 , MyoD , and myogenin ) . p 202 modulates the transcriptional activity of these factors in transfected cells . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| In response to oxidant stress , the cardiovascular system is known to express a number of genes , which could occur owing to the participation of mitogen activated protein kinases such as MAPKs , ERK and JNK ( SAPK ) followed by stimulation of at least two well defined transcription factors NF KB and AP 1 ( c Fos and c Jun ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Signal transduction pathways involved in the activation of NF kappa B , AP 1 , and c fos by Mycoplasma fermentans membrane lipoproteins in macrophages . ^^^ LAMPf was capable of inducing NF kappa B , activated protein 1 ( AP 1 ) , and c fos activation in macrophages and of stimulating NF kappa B and AP 1 transactivation . ^^^ Furthermore , we have delineated the contribution of each mitogen activated protein kinase pathway to the LAMPf mediated activation of AP 1 , c fos , and NF kappa B . ^^^ Whereas the selective extracellular signal regulated kinase pathway inhibitor PD 98059 did not affect the LAMPf mediated transactivation of AP 1 , c fos , or NF kappa B , the specific p 38 inhibitor SB 203580 abrogated this activity . ^^^ A c Jun N terminal kinase dominant negative was shown to block the activation of AP 1 without altering NF kappa B or c fos activation by LAMPf . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Some ubiquitously expressed genes seem unexpectedly to have unique functions that are largely confined to bone cells : M CSF , C Fos , PU . 1 , and NF kappaB are required for osteoclast formation , whereas c Src and Mitf ( microphthalmia transcription factor ) are required for osteoclast activity after the cells have formed . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF kappaB components p 50 and p 65 , and did not contain other NF kappaB proteins ( p 52 , c Rel , Rel B ) , AP 1 proteins ( c Fos , C Jun ) , CREB or C / EBPbeta ( NF IL 6 ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB is also involved in the regulation of the transcriptional activity of the c fos serum response factor ( SRF ) , since the activation of a SRE dependent promoter by RhoA can be efficiently interfered by the double mutant IkappaBalphaS32A / S36A , an inhibitor of the NF kappaB activity . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The AP 1 motif in the human p 53 promoter binds c Fos and c Jun and the NF kappaB motif binds p 50 ( NF kappaB ) and p65RelA . ^^^ The cooperative nature of transcriptional activation by these factors was documented by repression of c fos or NF kappaB 1 translation : Pretreatment of the cells with a c fos or p 50 ( NF kappaB 1 ) antisense oligonucleotide suppresses transcription from the human p 53 promoter completely . ^^^ In addition , we show that ( a ) the level of endogenous p 53 mRNA and ( b ) transcription from the strictly p 53 dependent human mdm 2 promoter are reduced in the presence of c fos , c jun , p 50 ( NF kappaB 1 ) , p65RelA or c myc antisense oligonucleotides , underscoring the importance of these transcription factors for the expression of functional p53 . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Activation of transcription factors such as NF kappaB and activator protein 1 ( AP 1 ) may be linked to increases in early response genes ( e . g . , c jun and c fos ) which govern proliferation , apoptosis , and inflammatory changes in the cells of the lung . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The presence of several transcription factor proteins , including JunB , JunD , c Fos , Fra 1 , CREB 1 , activating transcription factor 2 , NF KB p 50 , p 52 , and p 65 , and CAAT / enhancer binding protein delta , was demonstrated by supershift analysis . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Previous work by others and in our laboratory , using an in vitro uniform laminar shear stress model , has identified various shear stress response elements ( SSREs ) within the promoters of certain endothelial genes that regulate their expression by interacting with various transcription factors , including nuclear factor kappaB ( NF kappaB ) , early growth response 1 ( Egr 1 ) , and activator protein 1 ( AP 1 , composed of c Jun / c Jun and c Jun / c Fos protein dimers ) . ^^^ In the current study , we have examined the topographical patterns of NF kappaB , Egr 1 , c Jun , and c Fos activation in a specially designed in vitro disturbed laminar shear stress model , which incorporates regions of significant spatial shear stress gradients similar to those found in atherosclerosis prone arterial geometries in vivo ( eg , arterial bifurcations , curvatures , ostial openings ) . ^^^ Using newly developed quantitative image analysis techniques , we demonstrate that endothelial cells subjected to disturbed laminar shear stress exhibit increased levels of nuclear localized NF kappaB , Egr 1 , c Jun , and c Fos , compared with cells exposed to uniform laminar shear stress or maintained under static conditions . ^^^ In addition , individual cells display a heterogeneity in responsiveness to disturbed flow , as measured by the amount of NF kappaB , Egr 1 , c Jun , and c Fos in their nuclei . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NaDOC was found to activate transcription factors and induce or activate the promoters of genes that respond to protein malfolding ( grp 78 and hsp 70 ) , DNA damage ( gadd 153 , hsp 70 and c fos ) , oxidative stress ( NF kappaB , c fos , hsp 70 and gadd 153 ) , ER stress ( grp 78 ) and Ca++ imbalance ( grp 78 ) . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB and AP 1 components c Fos and c Jun were shown to physically associate by yeast two hybrid assays and electrophoretic mobility shift assays . ^^^ Coexpression of NF kappaB and c Fos or c Jun synergistically transactivated the HIV 1 LTR through the NF kappaB sites . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Ifi 202 encodes the p 202 protein whose overexpression is growth inhibitory and which can bind and inhibit the activity of numerous transcription factors including c Jun , c Fos , NF kappaB , E2F 1 , E2F 4 , MyoD , and myogenin . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis of nuclear extracts indicated that the AP 1 complex consists of c Jun , c Fos , JunD , and possibly JunB proteins , and that the NF kappaB complex contains p 50 , p 65 , and c Rel proteins . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Electrophoretic mobility shift assay showed that PDTC inhibited NF kappaB binding activity in heart and kidney , whereas AP 1 activity in the kidney was not decreased . dTGR exhibited increased left ventricular c fos and c jun mRNA expression . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| NF kappaB and AP 1 activities ; mucosal p 105 , p 50 , and inhibitor kappaB alpha ( IkappaB alpha ) levels ; and c fos , neurotensin , and ferritin H expression were determined by electrophoretic mobility shift assay and Western and Northern analyses , respectively . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| UbcH 7 is a ubiquitin conjugating enzyme mediating c fos degradation , transcription factor NF kappaB maturation , human papilloma virus mediated p 53 and Myc protein degradation , in vitro . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| We propose that interference or enhancement of endogenous p 300 function , by expression of exogenous fragments , can alter interactions with c Fos or NF kappaB and modulate signals during cellular stress . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Even 2 3 fold overexpression of p202a in cells retards proliferation . p202a was shown to modulate transcription by binding , and inhibiting the activity of several transcription factors including c Fos , c Jun , AP 2 , E2F1 , E2F4 , NF kappaB , MyoD , and myogenin . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The age related activation of AP 1 and NF kappaB in the gastric mucosa was associated with increased levels of c Jun , c Fos , and p 52 , but not p 50 or p 65 . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Valsartan prevented monocyte / macrophage infiltration , nuclear factor kappaB ( NF kappaB ) and activator protein 1 ( AP 1 ) activation , and c fos expression in dTGR hearts . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| In terms of cellular signaling , we present evidence that PGB ( 2 ) activates tyrosine kinase activities and efficiently increases c fos mRNA expression and nuclear factor kappa B ( NF kappa B ) translocation to the nucleus . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| In this paper , we attempted to investigate whether the transcription factors regulating the gene expression of c fos and nNOS , including activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappa B ) , and octamer factors ( Oct ) , are activated by CFA during the development of hyperalgesia . ^^^ Based on these findings , we conclude that AP 1 , NF kappa B and Oct are crucial for the expression of c Fos proteins at an early stage ( at 3 h ) and for the expression of nNOS at a late stage of hyperalgesia ( 48 h post injection ) induced by CFA . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| To understand the mechanism of neuronal apoptosis induced by herpes simplex virus ( HSV ) infection in vivo , the distribution of viral antigen , the appearance of apoptotic bodies , and the expressions of the tumor suppressor gene p 53 and several transcription factors such as c fos , c jun and NF kappaB were examined immunohistochemically and histopathologically after corneal infection of mice with HSV type 2 strain 186 . ^^^ Neuronal apoptosis was observed in the brain stem ipsilateral to the HSV infected side with the immunoreactivities of c fos , c jun , NF kappaB and p 53 . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| In addition , by immunohistochemistry , we performed staining for the NF kappaB subunits ( p 50 and p 65 ) and AP 1 subunits ( c fos , c jun ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The GM CSF promoted cell survival and proliferation correlated with MEK 1 dependent ERK1 / 2 , Elk 1 and CREB phosphorylation and Egr 1 , c Fos expression as well as with increased STAT 5 , AP 1 , c Myb and NF kappaB DNA binding . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| These genes included : phosphodiesterase 1C , cAMP dependent protein kinase , iNOS , beta NGF , proenkephalin B and orphanin , corticotrophin releasing factor ( CRF ) R , estrogen R , PAI 2 , and protease inhibitor 17 , NFkB p 105 , c fos , fos B , basic transcription factors , and cytoskeleton and motility proteins . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Short term treatment with 0 . 1 5 microM As ( 3 ) up regulates expression of c Fos and c Jun and the redox regulators , thioredoxin ( Trx ) and Redox factor 1 ( Ref 1 ) and activates both AP 1 and NF kappa B binding . ^^^ Chronic exposure to 0 . 1 or 0 . 5 microM As ( 3 ) decreased c Jun , c Fos and Ref 1 protein levels and AP 1 and NF kappa B binding activity , but increased Trx expression . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The exposure of mammalian cells to UV irradiation induces the expression of immediate early genes such as c jun and c fos and activates the transcription factors AP 1 and NF kappaB . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| In contrast to this generally accepted view of IKKalpha ' s physiological functions , we demonstrate in mouse embryonic fibroblasts ( MEFs ) that , akin to IKKbeta and NEMO / IKKgamma , IKKalpha is also a global regulator of tumor necrosis factor alpha and IL 1 responsive IKK signalsome dependent target genes including many known NF kappaB targets such as serum amyloid A 3 , C 3 , interleukin ( IL ) 6 , IL 11 , IL 1 receptor antagonist , vascular endothelial growth factor , Ptx 3 , beta ( 2 ) microglobulin , IL 1alpha , Mcp 1 and 3 , RANTES ( regulated on activation normal T cell expressed and secreted ) , Fas antigen , Jun B , c Fos , macrophage colony stimulating factor , and granulocyte macrophage colony stimulating factor . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| We conclude that CCY1a blocks cell proliferation via inhibition of the upstream effector of Ras and downstream events , including p42 / 44 MAPK activation and c fos and c jun mRNA expression , as well as NF kappa B and AP 1 DNA binding activities . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Of interest , we detected a significant decrease of NF kappaB , AP 1 , and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides ( NF kappaB , AP 1 , and CREB ) or Abs against various transcription factor subunits ( p 50 , p 65 , c Fos , Jun B , c Jun , and CREB 1 ) were added . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| However , TRAIL can also trigger transcriptional activations of the pro oncogene of c fos , JNK , and NF kappaB by other signaling pathways downstream of FADD / caspase 8 . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| IL 17 induced also HLA class 1 , C Fos , nuclear factor kappa B ( NF kappa B ) and C Jun expression by myoblasts but not that of HLA class 2 , CD 40 , vascular cell adhesion molecule 1 ( VCAM 1 ) and intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Under conditions where JNK 1 and ERK 2 were activated , BHA also activated transcription factors nuclear factor kappa B ( NF kappaB ) , activated protein 1 ( AP 1 ) , and anti oxidant response element ( ARE ) , leading to induction of genes such as c jun , and c fos . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We found that nuclear factor kappaB ( NF kappaB ) , as well as c Fos and c Jun , the components of activator protein 1 ( AP 1 ) , are activated after FcepsilonRI cross linking in human intestinal mast cells . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Also , simvastatin reduced NF kappa B and AP 1 dependent reporter gene activity in TNF alpha treated HT 1080 fibrosarcoma cells and reduced the nuclear levels of p 50 NF kappa B , p 65 NF kappa B , and the AP 1 components c fos and c jun in HMC . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Three predominant signaling pathways were identified to be inhibited by esculetin : ( a ) the activation of p42 / 44 mitogen activated protein kinase ( MAPK ) and the downstream effectors of c fos and c jun immediate early genes by means of western and reverse transcription polymerase chain reaction ( RT PCR ) analyses ; ( b ) the activation of nuclear factor kappaB ( NF kappaB ) and activator protein 1 ( AP 1 ) , using the electrophoretic mobility shift assay ; and ( c ) the activation of phosphoinositide 3 kinase ( PI 3 kinase ) and cell cycle progression , by western blot analysis and flow cytometric detection . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Although expression of the subunits of NF kappaB ( p 65 , p 50 ) and AP 1 ( c fos , c jun ) did not increase , irradiation caused a rapid and persistent translocation of p 65 and p 50 . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Proto oncogene ( c fos , c jun ) and nuclear factor kappa B ( NF kappaB ) expression , as well as DNA synthesis , in aortic and cerebral vascular smooth muscle cells ( VSMCs ) were upregulated by a decrease in extracellular magnesium ions ( [ Mg2+ ] o ) . ^^^ These data show that [ Mg2+ ] o may be an important , heretofore , overlooked natural modulator of proto oncogene and NF kappaB expression in VSMCs and that Ca2+ and PKC may play critical roles in induction of c fos and c jun in VSMCs induced by a decrease in [ Mg2+ ] o . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Besides its function in DNA repair , APE serves to maintain several transcription factors in an active reduced state such as c Fos , c Jun , NF kappaB , p 53 and HIF 1alpha , all of which have been shown to play a role in tumorigenesis . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| We found that dexamethasone ( Dex ) effectively suppressed T cell receptor induced ( TCR induced ) proliferation of naive CD4+ T cells , through a mechanism involving downregulation of c Fos expression and inhibition of activator protein 1 ( AP 1 ) , nuclear factor of activated T cells ( NF AT ) , and NF kappaB transcriptional activity . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Binding of NF kappaB p 50 , c Rel , p 65 , Sp 1 , Sp 3 , c Fos , and c Jun proteins to their cognate nuclear factor binding sites was somewhat impaired by HV infection , although a role for other as yet unidentified factors can not be dismissed . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Consistent with the increased expression of c Fos mRNA observed by RT PCR , the activation of c Fos occurred in osteoclast precursor cells stimulated by T ( 3 ) , while the activation of neither NF kappaB nor MAPKs was observed by immunoblot analysis . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Thus , our study revealed a distinct and essential role of NF kappaB in participating in the regulation of elk 1 , c fos , and VEGF expression . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The early oxidative stress response markers , NF kappaB transcriptional activation and c Fos gene expression , were significantly increased after spinal cord injury . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Piperine is a potent inhibitor of nuclear factor kappaB ( NF kappaB ) , c Fos , CREB , ATF 2 and proinflammatory cytokine gene expression in B16F 10 melanoma cells . ^^^ Immune regulation , induction of various inflammatory and growth regulatory genes such as IL 1beta , IL 6 , TNF alpha and GM CSF require activation of transcription factors such as nuclear factor kappaB ( NF kappaB ) , activated transcription factor ( ATF 2 ) , c Fos and cAMP response element binding protein ( CREB ) . ^^^ We found that the nuclear translocation of p 65 , p 50 , c Rel subunits of NF kappaB and other transcription factors such as ATF 2 , c Fos and CREB were inhibited by the treatment of piperine . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Mutational and biochemical analyses in the region 0 . 9 kb upstream of the transcription start site revealed that c Fos and JNK pathways , in addition to NF kappaB , participate in c src induction in response to RANKL . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Our results revealed that pretreatment with ISO significantly inhibited Ang 2 mediated NF kappaB through affecting the degradation and phosphorylation of IkappaBalpha and the activity of IKKbeta and AP 1 activation by influencing the expression of c Fos and c Jun proteins . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| MEK 1 dependent delayed expression of Fos related antigen 1 counteracts c Fos and p 65 NF kappaB mediated interleukin 8 transcription in response to cytokines or growth factors . ^^^ We report here that c Fos and Fos related antigen 1 ( Fra 1 ) , two inducible components of AP 1 , are recruited to the endogenous interleukin ( IL ) 8 promoter in an IL 1 dependent manner . c Fos activates IL 8 transcription and synergizes in this effect with p 65 NF kappaB . ^^^ Additional experiments reveal that , in conjunction with p 65 NF kappaB , the MEK 1 ERK dependent synthesis of c Fos and Fra 1 serves to adjust the overall expression level of IL 8 in response to two of its physiological inducers , IL 1 and epidermal growth factor . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Recent molecular genetic studies have identified several transcription factors , such as NF kappaB , c Fos , MITF , and NFATc 1 , which are essential for osteoclast differentiation . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Transcription factors implicated in the acquisition of NE characteristics by prostate cancer cells include STAT 3 , CREB , EGR 1 , c fos , and NF kappaB . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Arginine and glutamine had no differential effect on NF kappaB , whereas AP 1 expression ( c jun but not c fos ) was markedly enhanced by arginine and significantly lessened by glutamine . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Fourteen weeks later , the expression of PPARgamma , P 50 ( subunit of NF kappaB ) and c Fos ( subunit of AP 1 ) was determined by indirect immunofluorescence in the aortic endothelial cells . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Activation of NMDA receptors will also lead to activation of the early gene transcription factors including AP 1 ( c fos , c jun ) and NF kappaB which may play a role in modulation of the subsequent response to hypoxia . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Roles for NF kappaB and c Fos in osteoclasts . ^^^ NF kappaB and c Fos are transcription factors that are activated in immune cells and in most other cell types following stimulation by a variety of factors , including cytokines , growth factors , and hormones . ^^^ In this review , the RANKL / OPG / RANK system and roles for NF kappaB and c Fos in osteoclasts are reviewed along with our current understanding of how this system may be disrupted in common bone diseases , such as postmenopausal osteoporosis , inflammatory arthritis , and Paget ' s disease . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| These events lead to the down modulation of c Jun , c Fos , Egr 1 , and NF kappaB transcription factors and thereby inhibit production of cytokines , e . g . , IL 2 , IL 4 , IFN gamma , and TNF alpha , upon TCR stimulation . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Macrophage colony stimulating factor ( M CSF ) , receptor activator of NF kappaB ligand ( RANKL ) , and other osteoclastogenic ligands activate the NF kappaB components p 50 or p 52 , the AP 1 component c Fos , and NFATc 1 in osteoclast precursors . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| PC 12 pheochromocytoma cells expressing a dominant inhibitory mutant of Ha Ras ( M M 17 26 ) and PC 12 cells transfected with normal c RasH ( M CR3B ) have been used to investigate the role of nitrosylation and farnesylation of Ras on the production of homocysteine and the activities of the redox sensitive transcription factors NF kappaB and c Fos . ^^^ Furthermore , we have shown that manumycin increased the activity of c Fos in the M CR3B cells and decreased the activity of NF kappaB , while l NAME decreased the activities of both transcription factors , and accelerated apoptosis of M CR3B cells . ^^^ In contrast , in M M 17 26 cells manumycin did not change the activity of c Fos , nor the activity of NF kappaB . ^^^ We conclude that trophic factor withdrawal stimulates Ras , which apparently through the Rac / NADPH oxidase system induces permanent oxidative stress , modulates the activities of NF kappaB and c Fos , induces production of homocysteine and accelerates apoptosis . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| A treatment with silibinin to A 549 cells also led to a dose dependent inhibition on the activation of NF kappaB , c Jun and c Fos . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| METHODS : Tissue microarrays ( TMAs ) comprising 351 CRC specimens from 270 patients were constructed to evaluate the genes Adam 10 , Cyclin D 1 , Annexin 2 , NFKB , Casein kinase 2 beta ( CK2B ) , YB 1 , P 32 , Rad 51 , c fos , IGFBP 4 , and Connexin 26 ( Cx 26 ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The essential roles of NF kappaB and AP 1 in osteoclast differentiation have been clearly demonstrated in numerous studies . c Fos , a component of AP 1 transcription factor , plays a key role in osteoclast differentiation . ^^^ Momordin 1 remarkably inhibited the activation of NF kappaB as well as AP 1 in RANKL induced RAW264 . 7 cells , in which momordin 1 appeared to target IkappaB degradation and c Fos expression , respectively , but not MAPK signaling pathways . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| In archived biopsies from 15 healthy subjects exposed to DE [ particulates with a mass median diameter of < 10 mum , 300 microg / m3 ] and air , immunohistochemical staining was used to quantify the expression of the transcription factors NF kappaB ( p 65 ) and AP 1 ( c jun and c fos ) , as well their upstream MAPKs , p 38 and JNK , in the bronchial epithelium . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Concomitantly , the PPARgamma ligands diminished the cellular amount of mRNA encoding for IL 6 , CXCL 8 and CCL 5 and the RSV induced binding activity of the transcription factors NF kappaB ( p65 / p50 ) and AP 1 ( c fos ) , respectively . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Expression of mRNA for IL 2 and the NF kappaB dependent gene A 20 and of the AP 1 components c fos and c Jun was examined by quantitative RT PCR . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The upstream mediators of the effect involved c jun , c fos and NF kappaB , as evidenced by reduced phosphorylation of the proteins . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| CpG DNA evoked concomitant increases in intracellular superoxide and NO levels , leading to enhanced ONOO formation and , consequently , nuclear accumulation of c Fos and NF kappaB . ^^^ These results identify ONOO dependent activation of NF kappaB and c Fos as an important mechanism that mediates PMN responses , including IL 8 gene expression and release , to bacterial DNA and unmethylated CpG motifs in particular . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| In RAW264 . 7 cells , a monocyte / macrophage precursor for osteoclasts , both kaempferol and quercetin dose dependently inhibited the receptor activator of NF kappaB ligand ( RANKL ) induced immediate early oncogene c fos expression at 6 h . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Gel shift , enzyme linked immunosorbent , and chromatin immunoprecipitation assays revealed a strong induction of IL 18 mediated AP 1 ( c Fos , c Jun , and Fra 1 ) and NF kappaB ( p 50 and p 65 ) activation and stimulation of MMP 9 promoter dependent reporter gene activity in an AP 1 and NF kappaB dependent manner . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| These data reveal a novel in vivo role for c Fos as an anti inflammatory transcription factor acting through suppression of NF kappaB activity . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Both inhibited the activation of the transcription factor NF kappaB , but had no effects on activation of the AP 1 subunits c jun and c fos . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Whole cell and nuclear extracts from lymphocytes were immunoblotted for GR , c fos , JNK and NF kappaB and nuclear aliquots were submitted to electrophoretic mobility shift assay for GR , AP 1 and NF kappaB . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the metabolism of iprodione involves Phase 2 biotransformation in the liver ( XRE , GSTYa ) , and that this chemical has the potential to cause cell proliferation and / or inflammatory reactions ( c fos , NF kB ) , proteotoxic effects ( HSP 70 , GRP 78 ) , metabolic disruption ( CRE ) , and DNA damage ( GADD 45 , GADD 153 ) . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| In this study , we have investigated the expression of the nuclear transcription factor ( c Fos , NFkB ) , growth factors ( nerve growth factor NGF , brain derived neurotrophic factor BDNF ) , peptides ( enkephalin , galanin ) and glutamate transporter ( AA 504 523 rat EAAC 1 ) in 6 dogs sacrificed immediately after seizure attack during encephalomyelitis due to canine distemper virus ( CDV ) ( as assessed by clinical examination , RT PCR and viral RNA detection either in blood or brain tissue and CDV immunohistochemistry in brain slices ) . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Upon PMA stimulation , the levels of these corepressors are reduced and the promoter is rapidly bound and activated by transcription factors , including NF kappaB p 65 , C / EBPbeta , and c Fos . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| LPS stimulated both AP 1 ( c Fos , c Jun ) and NF kappaB ( p 50 and p 65 ) activation , but only inhibition of AP 1 attenuated LPS induced CXCR 6 expression . ^^^ |
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| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that the protein product of the ref 1 gene stimulates the DNA binding activity of Fos Jun heterodimers , Jun Jun homodimers and Hela cell AP 1 proteins as well as that of several other transcription factors including NF kappa B , Myb and members of the ATF / CREB family . ^^^ |
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| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| These elements share no apparent sequence motif and bind different trans acting proteins ; a member of the NF kappa B family binds to the HIV 1 enhancer , the heterodimer of Jun and Fos ( AP 1 ) binds to the collagenase enhancer , and the serum response factors p 67 and p 62 bind to fos . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Antibodies to fra 2 , a fos family member , and to the p 50 , but not the p 65 , subunit of NF kappa B supershift the Mod 1 complex . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The enhanced DNA binding of oxidized HoxB 5 protein is the opposite of the redox regulation reported for other mammalian transcription factors such as Fos , Jun , USF , NF kappa B , c Myb , and 5 Rel , in which oxidation of cysteine residues inhibits DNA binding . ^^^ |
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| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Super shift assays with DNA that contained the TRE motif revealed that the Fos and Jun proteins from nuclei of M 1 cells treated with LPS and H2O2 bound weakly to the TRE motif , and , in assays with DNA that contained the NF kappa B motif , nuclear protein from M 1 cells treated with H2O2 or LPS bound strongly to the NF kappa B motif . ^^^ |
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| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To identify the cells that express transcription factor NF kappa B subunits p 50 and p 65 in synovial tissue from patients with rheumatoid arthritis ( RA ) and to correlate the distribution of p 50 and p 65 with CD 14 ( macrophage lipopolysaccharide receptor ) and members of the AP 1 transcription factor family , Jun and Fos . ^^^ Different but overlapping distributions of nuclear p 50 and p 65 versus Jun and Fos indicate separate or divergent mechanisms for the activation of NF kappa B and the expression of AP 1 proteins in rheumatoid synovium . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Super shift assays using the TRE of the HO gene revealed that the Fos and Jun proteins from nuclei of M 1 cells treated with TPA bound to the TRE , and same assays using DNA with the NF kappa B motif also revealed that the active NF kappa B protein from M 1 cells treated with H2O2 or TPA also bound to the corresponding motif . ^^^ |
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| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Furthermore , overexpression and constitutive nuclear localization of NF AT , but not Jun , Fos , NF kappaB , Oct or Ets family members , renders the interleukin 2 enhancer in Jurkat T lymphocytes resistant to FK 506 and cyclosporin A . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Response elements for human CYP1A1 , GST lambda a , xenobiotic response element ( XRE ) , fos , HSP 70 , CRE , p 53 , NF kappa B and DNA damage ( GADD ) in HepG 2 cells were not activated by quercetin . 6 . ^^^ |
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| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| The GF induced hepatocellular proliferation was mediated through activation of immediate early genes such as Fos , Jun , Myc , and NFKB . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Both DNA binding and transactivation of AP 1 and NF kappaB transcription factors showed elevation in the anchorage independent ( 16RH ) and tumorigenic ( 18 5 fos ) keratinocyte lines compared to the less progressed but immortalized cell lines . ^^^ When a dominant negative mutant c jun driven by a human keratin 14 promoter was co transfected with AP 1 or NF kappaB reporters , both AP 1 and NF kappaB activities were suppressed in the more progressed cell lines 16RH and 18 5 fos but not in the less progressed 16RL or 18 cell lines . ^^^ Stable transfectants of this mutant c jun in the two more progressed cell lines 16RH and 18 5 fos showed reduced AP 1 and NF kappaB activation and reduced anchorage independent growth . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Changes in proto oncogene expression , determined by measuring Fos , Jun , and Myc mRNA levels as well as by the DNA binding activity of the AP 1 , AP 2 and NF kappaB transcription factors , were used as indicators of a general stress response . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Translocation of the transcription factor NF kappaB into the nucleus may also be regulated by PMD , based on a quantitative correlation similar to that found with fos . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of transcription factors fos / jun dimer activator protein ( AP ) 1 and nuclear factor kappaB ( NF kappaB ) plays a cardinal role in vascular smooth muscle cell ( SMC ) response to growth stimuli . ^^^ Increased nuclear binding of AP 1 and NF kappaB after injury was associated with increased expression of fos , jun , and p 105 subunit mRNA and restored the proliferative response of SMC after balloon injury . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| This action of TGF beta 1 did not correlate with NF kappaB activation , but associated with the translocation of Fos protein into the nucleus . . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| MATERIAL AND METHODS : From cDNA microarray screening of those specimens , several gene clusters , including Nos 2 and the transcription factors Fos , Fosl 1 , Jun and Nfkb 1 , were identified as possible upstream regulators of Na+ transport protein expression . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| A relatively high number of genes involved in innate and inflammatory host immune responses , including interleukin 8 , interleukin 6 , NF kappaB ( 2 ) , RELB and fos , were induced . ^^^ |
|
| Interacting proteins: P01100 and P19838 |
Pubmed |
SVM Score :0.0 |
| Hence , the activities of several transcription / nuclear factors for inflammatory mediators ( NF kappaB , NFAT ) are markedly reduced , while those of others ( Jun , Fos , Fra , p90rsk ) are unaltered . ^^^ |
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