| Interacting proteins: P17544 and P01100 |
Pubmed |
SVM Score :0.0 |
| We have used this vector to demonstrate the formation in vivo of complexes between the transcription factor ATFa , a member of the family of ATF / CRE binding proteins , and the c Jun or c Fos proteins . ^^^ |
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| Interacting proteins: P17544 and P01100 |
Pubmed |
SVM Score :0.0 |
| The ATF 7 proteins , which are members of the cyclic AMP responsive binding protein ( CREB ) / activating transcription factor ( ATF ) family of transcription factors , display quite versatile properties : they can interact with the adenovirus E1a oncoprotein , mediating part of its transcriptional activity ; they heterodimerize with the Jun , Fos or related transcription factors , likely modulating their DNA binding specificity ; they also recruit to the promoter a stress induced protein kinase ( JNK 2 ) . ^^^ |
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| Interacting proteins: P17544 and P01100 |
Pubmed |
SVM Score :0.0 |
| We also show that coexpression of ATFa with c Jun , Jun B or Jun D stimulates ATFa dependent reporter activity , while coexpression of c Fos has no effect . ^^^ The ATFa / c Jun heterodimers , but not the ATFa / c Fos complexes , bind efficiently to ATF , CRE or AP 1 sites . ^^^ Jun and Fos heterodimerize with ATFa , a member of the ATF / CREB family and modulate its transcriptional activity . ^^^ Reciprocal co immunoprecipitation experiments and electrophoretic band shift assays with in vitro synthesized proteins reveal direct interactions between ATFa and Jun or Fos . ^^^ Altogether these results indicate that the ATFa proteins may contribute to the modulation of the activity of the Jun / Fos complexes by altering their DNA binding and transcriptional properties . . ^^^ |
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| Interacting proteins: P17544 and P01100 |
Pubmed |
SVM Score :0.0 |
| In the absence of c fos gene expression , c Fos protein appears to be replaced by proteins of Fos family ( Fra 1 ) and ATF family ( ATF 2 and ATFa ) . ^^^ |
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| Interacting proteins: P17544 and P01100 |
Pubmed |
SVM Score :0.0 |
| The ATFa proteins , which are members of the CREB / ATF family of transcription factors , have previously been shown to interact with the adenovirus E1a oncoprotein and to mediate its transcriptional activity ; they heterodimerize with Jun , Fos or related transcription factors , possibly altering their DNA binding specificity ; they also stably bind JNK 2 , a stress induced protein kinase . ^^^ |
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| Interacting proteins: P17544 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
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