Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We studied levels of mRNAs for several immediate early genes : c fos , NGFI A , NGFI B , c jun , junB and junD , before and after light exposure at these phases . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Carbachol and thrombin have similar effects on expression of c fos , fosB , fra 2 , junB , and junD , both acutely and over a 24 h time course . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We have shown that while c Fos is the major Fos protein associated with the Jun proteins ( c Jun , JunB , and JunD ) soon after serum stimulation , at later times Fra 1 and Fra 2 are the predominant Fos proteins associated with the different Jun proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The present paper describes the effect of capsaicin induced stressful stimulus on the expression of immediate early genes ( IEGs ) c fos , c jun , junB and junD in the hypothalamic paraventricular nucleus ( PVN ) and the central amygdaloid nucleus ( ACe ) using in situ hybridization . ^^^ Stress caused an intense expression of c fos , c jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We also show that c Fos does not affect the inhibitory function of CREM on c Jun and that the transcriptional activation elicited by the other members of the jun family ( JunB , JunD , and 5 Jun ) is also down regulated by CREM . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Northern analysis indicates that mRNAs for at least six members of the Fos / Jun family ( c fos , fosB , fra 1 , c jun , junB , and junD ) are expressed in activated Ar 5 cells ; thus the AP 1 sites of the IL 2 promoter may bind different dimeric Fos / Jun complexes at different times after T cell activation , perhaps mediating both positive and negative regulation of the IL 2 promoter . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Okadaic acid treatment was found to dramatically increase mRNA transcripts of the jun family of proto oncogenes including c jun , junD , and junB and to a lesser extent the fos family including c fos and fra 1 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We have characterized the expression of c Jun , JunB , JunD , c Fos , and FosB proteins following serum stimulation of quiescent Swiss 3T3 cells by immunoprecipitation analyses . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Consistent with this result , these cell lines expressed increased levels of mRNAs encoding the AP 1 proteins , c Fos , Fra 1 , c Jun , JunB , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
To determine whether these proteins are required for cell cycle progression , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , c Jun , JunB , and JunD , and antibodies that recognize either the Fos or the Jun family of proteins , into Swiss 3T3 cells and determined their effects in cell cycle progression by monitoring DNA synthesis . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The PMA induction of c fos mRNA correlated well with TNF gene induction ; expression of genes encoding other proteins in the AP 1 complex ( junB and junD ) were also induced by PMA . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In both tissue biopsies and derivative cell lines , the proto oncogenes junB and c jun are induced in the latter two stages , in contrast to junD and fos . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
As expected , in vitro translated VJ GLZ was found to be incapable of forming heterodimers with c Fos , FosB , and JunD . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
These data are consistent with a model ( figure 4 ) in which preexisting JunD mediates the rapid cAMP dependent activation of the proenkephalin enhancer , whereas IEGs such as JunB or c Fos mediate the protein synthesis dependent inactivation . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In contrast , DMSO induced differentiation of F MELC is associated with an early and transient induction of c fos and junB mRNAs by 2 to 8 h treatment while in presence of dexamethasone , an inhibitor of F MELC commitment , c fos mRNA is not detected and junB mRNA remains at basal levels . junD mRNA is detected at low levels in untreated F MELC and remains unchanged during DMSO treatment . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Administration of kainate or pentylenetetrazole increased c fos , c jun , junB , and junD mRNA levels in rat brain in a dose dependent manner . ^^^ Adrenalectomy significantly potentiated kainate induced increases , compared with increases caused by kainate ( 4 mg / kg ) alone , in the hippocampal mRNA levels of c fos and junB by 6 . 5 fold and of junD by twofold and tended to augment c jun mRNA . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We have used primary neuronal cultures prepared from fetal cerebral hemispheres to investigate the effects of different glutamate receptor agonists and antagonists on the expression of transcription factor encoding genes , such as c fos , fosB , c jun , junB , junD , c myc , and zif / 268 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
JunB and JunD were poorer inhibitors . c Fos expression did not potentiate the negative effect of Jun . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Additionally , HGF induced increased transcription of c fos , c jun , junB , junD , and c myc early response genes in both cell lines . ^^^ We therefore suggest that the second messenger proteins PI3K , GAP and NCK , and possibly the protein products of the c fos , c jun , junB , junD and c myc genes , are important elements in the HGF induced mitogenic pathway in the normal mouse epithelial cell lines M 23 and MM55 . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Short term stimulation ( up to 16 hours ) of interleukin 3 ( IL 3 ) dependent mouse bone marrow derived mast cells , Abelson transformed mouse liver derived mast cells , or rat basophilic leukemia cells by either IgE Ag or calcium ionophore A 23187 resulted in inhibition of their proliferation as measured by 3H thymidine incorporation and MTT ( tetrazolium ) assays , and in accumulation of the mRNAs of c fos , c jun , junB and slightly of junD proto oncogenes . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Like c Fos and Fra 1 , Fra 2 formed stable heterodimers with c Jun , JunB or JunD in vitro and all these complexes had specific DNA binding activity to AP 1 binding sites ( AP 1 sites ) or related sequences . ^^^ Interestingly , this suppressive effect of Fra 2 was not observed in the combination with JunD : fra 2 plus junD , like c fos plus junD , had higher transcriptional activity than junD alone . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
It led to an accumulation of milk in the glands and was accompanied by an induction of protein kinase A , AP 1 DNA binding activity and elevated c fos , junB , and junD mRNA levels . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In the present study we analysed , by in situ hybridization , the effects of an extremely localized mechanical brain injury , obtained by the simple needle insertion ( 30 g ) in rat hippocampus or cortex , on the expression of several immediate early genes ( c fos , fosB , c jun , junB , junD , zif / 268 ) . ^^^ Maximal effects are detected between 30 and 60 min with the following rank order of induction : zif / 268 > c fos > junB > fosB > c jun > junD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Colocalization of NDP with c Jun , JunB , JunD , c Fos , FosB and Krox 24 transcription factors was investigated in neurons of lumbar spinal cord . c Jun , JunB , c Fos and Krox 24 reached their maximal levels of expression 2 h after FOR and returned to basal levels after 10 h . ^^^ In a low number of NDP neurons , suprabasal immunoreactivity of JunB , c Fos and Krox 24 proteins was visible up to 10 h , and of JunD and FosB up to 24 h in sDH neurons ; c Jun was not expressed in NDP labelled neurons of sDH , but , similar as JunD , showed basal colocalization in preganglionic sympathetic and parasympathetic neurons . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In electrophoretic mobility shift assays using nuclear extracts from cultured cells and primary tissues , several AP 1 proteins ( c Jun , JunB , JunD , and c Fos ) bound the cyclin D 1 954 region . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Differential induction and regulation of c jun , junB , junD and c fos by human papillomavirus type 11 E5a oncoprotein . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Basal expression of the inducible transcription factors c Jun , JunB , JunD , c Fos , FosB , and Krox 24 in the adult rat brain . ^^^ The expression of c Jun , JunB , JunD , c Fos , FosB , and Krox 24 was investigated in the brain of untreated male Sprague Dawley and female BDIX rats by immunocytochemistry using specific antibodies . ^^^ JunD was expressed at high levels in those areas that also exhibit c Jun , JunB , c Fos , and FosB IR , such as locus coeruleus , periolivary nuclei ( ncl . ) , pontine and central gray , lateral lemniscal ncl . , inferior and superior colliculi , leaflet of geniculate ncl . , midline nuclei of thalamus , dorsomedial and paraventricular ncl . of hypothalamus , ncl . supraopticus , dorsolateral part of caudate putamen and lateral septal ncl . ^^^ In contrast to the high number of JunD positive neurons , c Jun , JunB , c Fos , and FosB proteins were detected in rather low numbers of neurons in these brain areas ; the rank of the number of immunopositive neurons was c Fos > JunB > c Jun > FosB . ^^^ Apart from a weak JunD IR , some areas did not express Jun , Fos , and Krox proteins such as cuneate and gracile ncl . , venterobasal complex of thalamus , globus pallidum , and Purkinje cells of the cerebellum . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In this study we investigated the expression of the immediate early genes ( IEGs ) c fos , c jun , and junD on mRNA and protein levels during the spermatogenic cycle of the rat using Northern blotting , in situ hybridization , and immunocytochemistry . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We now report that in both quiescent and non quiescent mouse bone marrow derived cultured mast cells ( BMCMC ) rrSCF 164 induces increased mRNA levels for the `` early response genes ' ' c fos , c jun and junB but has only slight effects on the expression of junD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In the present study we have investigated the induction of immediate early gene ( IEG ) c fos , c jun , junB and junD mRNAs and proteins in interstitial cells of rat testis after hCG treatment in vivo using in situ hybridization and immunocytochemistry . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In a similar manner , we generated a series of conditionally active JunD and c Fos proteins by fusing their carboxyl ( COOH ) terminal ends with a COOH terminal fragment of the human estrogen receptor ( ER ) that contains the ligand binding domain . ^^^ JunD ER ( DER ) and Fos ER ( FER ) chimeras with an intact leucine zipper and basic region exhibit hormone dependent activation of activator protein 1 directed transcription in transient expression assays . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
When these morphologically altered CEF were challenged by superinfection with oncogenic retroviruses , they were resistant to transformation by the nuclear oncogenes jun , fos , junD , myc , and qin but were readily transformed by cytoplasmic oncogenes src , mil / raf , ras , and fps . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Using model spontaneously reverting cell lines , c jun , junB , junD and c fos oncogene expression was investigated . c jun , but not junB , junD or c fos , was overexpressed in highly tumorigenic clones . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Purified TAP 1 is a multicomponent complex composed of 38 kDa and 43 kDa junD polypeptides in association with a separate factor ( s ) , distinct from fos , that partly dissociate from the complex during affinity purification but is required for full TAP 1 DNA binding activity . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Exposure of HT 1080 cells to OA resulted in marked and persistent induction of junB , junD , and c fos mRNA levels up to 24 h , while c jun mRNA levels were only slightly elevated . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Rat hearts infused with the beta adrenergic agonist isoproterenol were examined for the expression of several nuclear proto oncogenes ( c fos , fosB , c jun , junB , and junD ) and the immediate early gene Egr 1 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
To determine if axotomy induced immediate early gene ( IEG ) expression accompanies regenerative efforts in central nervous system ( CNS ) neurons , immunohistochemistry using antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins was used to examine gene expression in identified adult rat retinal ganglion cells ( RGCs ) under two conditions : ( 1 ) after axotomy alone , and ( 2 ) 1 month after replacement of the optic nerve with an autologous peripheral nerve graft to allow axonal regrowth . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
This factor bound JunB , JunD and Fos antibodies . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The AP 1 site binding complex ( es ) induced by all three treatments reacted with antibodies directed broadly against fos and jun protooncogene families and against the specific family members c fos , junB , and junD but not c jun proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The effect of a single injection of caffeine on the expression of c fos , c jun , junB , and junD , on activator protein 1 ( AP 1 ) and on the levels of preproenkephalin mRNA in rat striatum was studied . ^^^ A strong induction of junB , a weak induction of c fos and c jun , but not of junD , was seen in nucleus accumbens . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The expression of seven immediate early gene encoded transcription factors ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif / 268 ) was assessed simultaneously . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
These elements include a proximal cyclic AMP response element ( CRE ) / AP 1 like motif ( TGACATCA ) that binds c Jun , JunD , CRE binding ( CREB ) , and ATF proteins , a near consensus glucocorticoid response element , and a distal consensus AP 1 site that binds c Fos , Fra 1 , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Immunohistochemistry and gel mobility shift assays suggest that AP 1 activity during the night and after a light pulse consists of constant , as well as variable , protein components ; JunD could be identified as a constituent of both dark and light activated binding complexes , whereas binding by JunB and Fos could be implicated only after photic stimulation . ^^^ Since JunD or JunB could be colocalized with Fos in individual suprachiasmatic nucleus cell nuclei , light may be acting in at least some suprachiasmatic nucleus cells by altering AP 1 protein composition rather than binding site occupancy . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Stimulation of several second messenger pathways induces the expression of immediate early genes such as c fos , c jun , junB , and junD , but little is known about their induction via the stimulation of the cyclic GMP pathway . ^^^ We found that expression of c fos and junB but not of c jun or junD is increased upon activation of cyclic GMP pathway . c fos mRNA expression was the most activated ( fourfold at 30 min ) , whereas junB response was more modest ( 2 . 2 fold activation at 60 min ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Compared with the wild type JunD , none of them showed enhanced transactivating activity in the forms of homodimers or of heterodimers with c Fos or Fra 1 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Although CREB , c Fos , c Jun , and JunD did not have significant effects , JunB inhibited the Tax dependent transactivation . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Acute administration of the typical neuroleptic haloperidol ( HAL , 2 mg / kg ) induced the immediate early gene proteins ( IEGPs ) c Fos , Fos related antigens ( FRAs ) , FosB , JunB , JunD and Krox 24 in the striatum and nucleus accumbens of the rat brain . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We have characterized the genomic response of astroglial cells to excitatory amino acids by using selective agonists and antagonists for the various receptor subtypes and by analyzing different primary response genes , such as members of the Fos ( c fos and fosB ) and Jun ( c jun , junB , and junD ) families , zif / 268 , and c myc . ^^^ A rapid and transient elevation of mRNA levels for c fos , fosB , c jun , junB , and zif / 268 was observed after addition of glutamate to cultured astrocytes , whereas junD and c myc expression was not affected . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Protein kinase A and AP 1 ( c Fos / JunD ) are induced during apoptosis of mouse mammary epithelial cells . ^^^ Elevated nuclear protein kinase A ( PKA ) activity was observed from one day post lactation , paralleled by increased c fos , junB , junD and to a lesser extent c jun mRNA levels . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Experiments were performed on pheochromocytoma 12 ( PC 12 ) , hepatoblastoma ( Hep3B ) , neuroblastoma and fibroblast cells that were exposed either to normoxia ( 21 % O 2 ) or to hypoxia ( 5 % O 2 ) for one hour . mRNAs for c fos , c jun , junB , junD were analyzed by northern blot assay . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Immunoblots found that c fos is induced in the adrenal medulla near maximally by one hour immobilization and cJun and JunD are present in higher constitutive levels and are only moderately regulated by immobilization stress . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Since we previously found that activation of mast cells by IgE antigen ( Ag ) induces the mRNA accumulation of c fos , c jun , junB and junD proto oncogenes , we were prompted to investigate whether serum could affect such accumulation in these cells . ^^^ Mast cells , which were cultured in the presence of fetal calf serum ( FCS ) , were characterized by a high proliferation rate and high accumulation of the mRNA of c fos , junB and junD proto oncogenes . ^^^ After sustained FCS deprivation both DNA synthesis and the level of c fos mRNA were significantly decreased , as expected , whereas the level of c jun , junB and junD mRNA were not affected . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The proto oncogenes c jun , junB , junD , and c fos recently have been shown to encode for transcription factors with a leucine zipper that mediates dimerization to constitute active transcription factors ; juns were shown to dimerize with each other and with c fos , whereas fos was shown to dimerize only with juns . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The serum induction of c fos and junD as well as the serum and TPA ( 12 O tetradecanoylphorbol 13 acetate ) induction of junB and egr 1 are almost completely abolished . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Overexpression of cJun or JunD , but not JunB , also eliminates the requirement for PMA , indicating that many but not all Jun and Fos related proteins functionally activate NF AT dependent transcription in the presence of the cytoplasmic component . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Elevated binding activity of AP 1 also correlated with elevated levels of c jun , junD , junB , and c fos mRNAs . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Within 15 minutes of balloon injury , mRNA levels of c fos , fosB , c jun , junB , and junD were elevated severalfold . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Prolactin ( PRL ) injected subcutaneously increased hepatic ODC activity as well as mRNA levels of ODC and the proto oncogenes c fos , c jun , junB , junD , c myc , and max . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Glutathione s transferase B ATF heterodimerizes efficiently with in vitro translated JunB , c Jun , and JunD , but only weakly associates with c Fos . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The AP 1 protein complex at 21 days postnatally was composed of JunD , JunB , Fra 2 , FosB and to much lesser extent of c Fos in both cortical areas . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Mobility shift assays with UM SCC 1 nuclear extract revealed binding of fos and junD proteins to an oligonucleotide spanning the AP 1 site at 1967 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Using a glutathione S transferase ( GST ) fusion protein system , we show that E 7 complexes with AP 1 transcription factors including c Jun , JunB , JunD and c Fos . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In this study , evidence is presented that EPO induces the expression of early response genes c jun , junD and c fos mRNA , stimulates jun protein synthesis and induces activation of 5 10 AP 1 / CAT activity in hyman erythroleukemia K 562 cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
TCDD did not increase mRNA of c fos , c jun , junB or junD ( in contrast to TPA which markedly increased the expression of c fos and junB ) , nor did TCDD increase AP 1 activity . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays with the 231 to 172 probe demonstrate JunD and Fos binding in both control and induced nuclear extracts ; however , binding of c Jun is only detected following LPS stimulation . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Complement activation and TCC assembly induced expression of c jun , JunD , and c fos mRNAs , increased AP 1 DNA binding activity within 1 h , and increased [ 3H ] thymidine uptake . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Brief visual stimulation ( 2 hr ) added c Fos , c Jun , and JunB to this complex , whereas prolonged stimulation ( 6 24 hr ) reduced c Fos and c Jun levels significantly , leaving only FosB , JunB , and JunD as the major components of AP 1 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Similarly , the complexes binding the consensus AP 1 TRE and jun TRE like motifs in cells exposed to oxidative signals or PHA / PMA were indistinguishable , being composed of c Fos , c Jun , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Calcium induced AP 1 DNA binding complexes consist of Fra 1 , Fra 2 , c Jun , JunB and JunD and are independent of c Fos , since the induction of DNA binding activity and the composition of the AP 1 binding complexes are identical in differentiating keratinocytes derived from c fos null and wild type mice . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
RESULTS : Cotransfection of HIV 1 provirus and expression plasmids for c Jun or JunB into SW 480 cells resulted in increased p 24 core antigen and this response was markedly increased following PMA stimulation of cells . c Fos or JunD alone did not increase p 24 production but markedly increased p 24 production in PMA stimulated cells . ^^^ PMA increased c Fos and JunD binding activity on an AP 1 binding site within the U 5 region of the LTR , as shown in gel mobility shift assays . ^^^ Functional analysis of this site by transient transfections demonstrated it was required to mediate c Fos and JunD transactivation of the HIV 1 LTR . ^^^ Taken together , the data indicate that AP 1 binding sites downstream of the transcriptional start site in the HIV 1 LTR are capable of binding c Fos and JunD and may contribute to transactivation of HIV 1 provirus . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Analysis of the accumulation of mRNA encoding members of the AP 1 transcription factor family demonstrated that c fos and junB are also expressed upon stimulation of NK and T cells with IL 2 , but not IL 12 , whereas expression of c jun and junD is not modified by either cytokine . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The effects of intracerebroventricular ( i . c . v . ) injections of angiotensin 2 ( Ang 2 ) on the expression of inducible transcription factors ( ITF ) ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 ) in the brain of conscious rats were assessed immunohistochemically using polyclonal antisera . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Analysis of the induced binding complexes indicates that c fos , c jun , and ATF 2 were present , but also two additional jun family members , JunB and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In a previous study , we have shown that treatment of mouse hepatoma cells with TCDD or B ( a ) P results in an increase in mRNA levels of the immediate early protooncogenes c fos , c jun , junB , and junD , and the concomitant increase of the DNA binding activity of the transcription factor AP 1 , a dimer of FOS and JUN proteins . ^^^ In mouse hepatoma Hepa 1 cells , which have Ah receptor ( AHR ) and Ah receptor nuclear translocator ( ARNT ) proteins , inclusion of TRE , SRE , and the AhRE motifs from c jun and junD , but not CRE or the AhREs from c fos , fosB , and junB , causes a large TCDD dependent increase in luciferase expression . ^^^ In agreement with these results , c jun and junD , but not c fos , fosB , and junB AhREs , competed with a canonical Cyp1A1 AhRE for binding to the AHR ARNT heterodimeric complex . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We found that Zif 268 , a transcription factor regulated by neuronal activity , accumulated in patches in the anterior temporal lobe during visual stimulus stimulus association learning , whereas other transcription factors , c Fos and JunD , were not . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Exposure of human neuroblastoma SH SY5Y cells to ethanol for 2 4 days caused a dose dependent increase in c jun and junD mRNA levels , whereas mRNAs for c fos , fosB and junB were not detectable in control or ethanol treated cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Constitutive binding of further factor proteins to DNA , such as JunD , c Fos and FosB , was detected in several patients whereas the localisation and DNA binding of other factors such as c Jun , RelA / p65 and c Rel was unaltered . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Using antibodies to transcription factors of the Fos and Jun families , we show that the nuclear proteins comprising the inducible TH AP 1 complex include c Fos , c Jun , JunB , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In this report , we show that this inducible CyRE binding protein is composed of the AP 1 proteins c Fos , JunB , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Induction of c fos , c jun , junB and junD mRNA and AP 1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) and its relationship to cell death , mutation induction and chromosomal instability . ^^^ To address the questions of whether ( a ) methylating agents that are powerful carcinogens are effective in induction of fos and jun mRNAs , ( b ) induction is affected by the repair capacity of the cells , and ( c ) induction is accompanied by genotoxic effects , the levels of c fos , c jun , junB and junD mRNA were analysed in isogenic Chinese hamster cell lines deficient ( phenotypically Mex ) and proficient ( Mex+ ) for the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) after treatment with N methyl N ' nitro N nitrosoguanidine ( MNNG ) and methyl methanesulfonate ( MMS ) . ^^^ Most responsive were c fos and c jun ( up to 80 fold increases in mRNA level ) whereas junB ( up to ninefold ) and junD ( up to twofold ) displayed an intermediate and weak response , respectively . ^^^ However , for MMS and UV light , which was included in this study for comparison , c fos , c jun , junB and junD mRNA as well as AP 1 induction paralleled the dose response for induction of cell killing effects , recombination and chromosomal breakage indicating that increased expression of Fos and Jun is related to the generation of MMS and UV induced genetic changes . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In the conceptus , the steady state concentrations of c fos , c jun , junB and junD mRNAs were induced , peaking at 0 . 5 hr and returning to base line by 1 to 2 hr in the embryo and by 1 to 6 hr in the yolk sac . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In order to establish what role members of the activating protein 1 ( AP 1 ) gene families , i . e . , c fos , c jun , junB , and junD , play in thymic apoptosis , we have analyzed changes in their expression in response to three different agents : a glucocorticoid analog dexamethasone , an inhibitor of topoisomerase 2 teniposide VM 26 , and gamma radiation . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
RESULTS : Cotransfection of cells with Tat / Jun and the AP 1 PL LUC or LTR AP 1 CAT reporter plasmid resulted in a marked increase in reporter gene activity which was comparable with that induced by transfection of cells with several different AP 1 expression plasmids ( e . g . , JunD , JunB , c Fos ) , or that elicited by stimulation of the cells transfected with LTR AP 1 CAT plasmids with phorbol ester or tumor necrosis factor alpha . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift assays , using Jun and Fos family member specific antibodies , showed that protein complexes formed by AtT 20 cell nuclear extracts bound to the c jun AP 1 site were comprised of Jun family members , JunD , JunB , and cJun . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
However part of this activation may be due to the formation of heterodimers with a member of the Jun family ( like JunD for example ) , since a wild type c Fos expression vector confers a 3 fold activation under these conditions . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The cAMP induced NF kappaB complex contained p 50 and RelB ; in co transfection assays , p 50 and RelB transactivated a reporter construct containing the c myb intronic NF kappaB site upstream of a minimal promoter . 8 Br cAMP and forskolin also increased the DNA binding activity of AP 1 complexes containing JunB , JunD and c Fos in MEL cells which could cooperate with NF kappaB . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
All the known components of chicken AP 1 ( c Fos , Fra 2 , c Jun , and JunD ) were detected in both cell types , but the expression level of c Jun was much higher in LS cells , which are rich in less mature chondrocytes than US cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Finally , immunocytochemical dual labeling was used to show that more than 75 % of all FSHbeta containing cells in ovine pituitary sections from cycling ewes contained nuclear c Jun , JunB , JunD , and Fos proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Among a group of immediate early response genes , including egr 1 , junB , c jun , junD , and c fos , only egr 1 stimulation was modulated by changes in medium pH . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The AP 1 DNA binding activities in all regions at all times after withdrawal were composed of FosB , c Jun , JunB , and JunD . c Fos was detected at all times in the cerebral cortex , at 16 h only in the hippocampus , and from 16 to 72 h in the cerebellum . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
After stimulating arterial baroreceptors by blood pressure increase due to phenylephrine , c Fos , FosB , c Jun and JunD / choline acetyltransferase ( ChAT ) positive neurons were surveyed in the medulla . ^^^ In the phenylephrine pressor test experiment , we ascertained that in the target neurons fosB was more sensitive to baroreceptor stimulation than any other immediate early genes such as c fos , c jun and junD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
This TRE bound TPA induced specific nuclear complexes in vitro containing junD , c jun , c fos , and fra 2 but not cAMP responsive element binding / activating transcription factor family proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Among other IEGs , junB and NGFI A again were similar to c fos while c jun and junD were more constant . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
SB 203580 , an inhibitor of p38 / RK , has been used to analyse the role of this kinase in the induction of five IE genes ( c fos , fosB , c jun , junB and junD ) under diverse conditions of stimulation . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
EGF treatment triggered almost identical programs of fos and jun gene activation at the messenger RNA ( mRNA ) level in both cell types , with an early accumulation of c fos , c jun , and junB mRNAs , but no change in junD mRNA levels . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The effect of c jun is exerted through interactions with c fos at the AP 1 motifs in the target promoters , whereas both junB and junD act independently of the binding at the AP 1 sites . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The expression of inducible transcription factors was studied following repetitive electroconvulsive seizures ( ECS ) , c Fos , c Jun , JunB , and JunD immunoreactivities were investigated following a single ( 1 10 ECS ) or repetitive ECS evoked once per day for 4 , 5 , or 10 days ( 4 10 ECS , 5 10 ECS , or 10 10 ECS ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Gel mobility shift and supershift assays revealed that TPA treatment of HepG 2 results in increased binding activity of the AP 1 proteins , c Jun , JunD , and c Fos , to both sites . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Fos and Jun nuclear factors bound constitutively to this site as identified by supershift analysis in electrophoretic mobility shift assays , and oncostatin M ( but not IL 6 ) induced an additional `` complex 2 ' ' that contained c Fos and JunD . ^^^ Fos and Jun nuclear factors bound constitutively to this site as identified by supershift analysis in electrophoretic mobility shift assays , and oncostatin M ( but not IL 6 ) induced an additional `` complex 2 ' ' that contained c Fos and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We studied the time course of expression of the inducible transcription factors ( ITF ) c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 , induced by a single intracerebroventricular injection of angiotensin 2 , in the subfornical organ ( SFO ) , median preoptic nucleus ( MnPO ) paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . c Fos and Krox 24 were expressed rapidly in neurons of all four areas but completely disappeared after 4 h . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The expression of c Jun , JunB , JunD , c Fos and ATF 2 transcription factors was studied in L4 / L5 dorsal root ganglion neurons of adult rats , in order to determine the extent to know to which extend the expression of transcription factors in vitro parallels the pathophysiological expression in vivo . ^^^ Incubation with brain derived neurotrophic factor for 15 days reduced JunB expression and raised c Fos expression , but did not affect c Jun or JunD labelings . ^^^ JunD dropped from its basal levels within 4 h and was almost absent after 8 h . c Fos did not appear until 6 h , when transferase dUTP nick end labelling also became detectable , and remained visible in a rather small number of neurons . ^^^ As with culture , incubation of explanted dorsal root ganglia with brain derived neurotrophic factor prevented the initial rise in JunB , accelerated and enhanced c Fos expression , but did not alter c Jun and JunD expression . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift experiments revealed that JunD and c Fos proteins mediated anti CD 19 induced AP 1 binding activity in 1E8 cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The densities of Fos , FosB , Fra 1 , Jun and JunD immunoreactive nuclei induced by haloperidol and sulpiride in the hippocampus , piriform cortex and accumbens nucleus were higher than those in the control groups . ^^^ These results suggested that induced Fos , FosB , Fra 1 , Jun and JunD proteins constitute the activator protein 1 complex after the administration of haloperidol and sulpiride . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The blockade of KA induced proENK and proDYN mRNA levels by the pre treatment with L ARG was well correlated with proto oncoprotein levels , such as c Fos , Fra 2 , FosB , JunD , JunB , and c Jun , as well as AP 1 and ENKCRE 2 DNA binding activities . ^^^ The pre administration with L NAME further increased KA induced c jun and c fos mRNA levels in addition to their protein product levels , although the pre treatment with L NAME did not affect KA induced FosB , Fra 2 , JunB , and JunD protein levels at 6 h after treatment . ^^^ Our results suggest that L ARG plays an important role in inhibiting KA induced proENK or proDYN mRNA expression , and its inhibitory action may be mediated through reducing the proto oncoprotein levels , such as c Fos , Fra 2 , FosB , c Jun , JunD , and JunB . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Alterations in levels of the immediate early gene ( IEG ) proteins Fos , FosB , DeltaFosB , Jun , JunB , JunD , and NGFI A were investigated in rat hippocampus by immunohistochemistry 2 , 12 , 24 , and 48 h after forebrain ischemia . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Stimulation with carbachol induced expression of c fos , fosB , c jun , junB , and junD . ^^^ Inhibition of protein kinase C with GF109203X suppressed the carbachol stimulated increase in mRNA levels of c fos , fosB , and junB by approximately 70 % but had only minor effects on the expression of c jun and junD . ^^^ On the other hand , preincubation with KN 62 attenuated the carbachol induced increase in c jun and junD expression by 70 % but had no effect on c fos , fosB , and junB mRNA levels . ^^^ Simultaneous inhibition of both protein kinase C and Ca2+ / calmodulin dependent kinase 2 completely abolished the carbachol stimulated expression of c jun and junD , but c fos , fosB , and junB were still expressed to a certain extent under this condition . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Anisomycin desensitization of a panel of IE genes ( c fos , fosB , c jun , junB , and junD ) , using epidermal growth factor ( EGF ) , basic fibroblast growth factor , ( bFGF ) , tumor necrosis factor alpha ( TNF alpha ) , anisomycin , tetradecanoyl phorbol acetate ( TPA ) , and UV radiation as secondary stimuli , was found to be extremely specific both with respect to the secondary stimuli and at the level of individual genes . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
HCG induced a rapid and transient expression of c fos , fosB , c jun , junB , junD and c myc with a peak at 30 min to 1 h . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Finally , by using electrophoretic mobility shift assays and antibody supershift analysis , we propose that c Fos , c Jun , and JunD may play major roles in the collagenase 3 activation by TGF beta 1 in human fibroblasts . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In this report , we demonstrate that the cAMP mediated regulation of transcription from the dopamine beta hydroxylase promoter is mediated by the AP 1 proteins c Fos , c Jun , and JunD . ^^^ Following treatment of cultured cells with cAMP , protein complexes bound to the dopamine beta hydroxylase AP1 / cAMP response element element change from consisting of c Jun and JunD to include c Fos , c Jun , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Fos antagonizes the junD gene positive autoregulatory loop ; a novel c Fos role in promoter switching . ^^^ We found that c Fos , a bZip protein known to be induced by serum and TPA , is sufficient to antagonize the JunD function . ^^^ Furthermore , selective activation of the junD promoter by JunD is abolished by c Fos with concomitant activation of the collagenase promoter . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We demonstrated increased binding activity to the AP 1 and CREB / ATF 2 consensus binding sites and show that the AP 1 complex is composed of c Jun , JunD , c Fos , and ATF 2 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The delayed increase in COX 2 mRNA expression was accompanied by the induction of the proto oncogenes c jun , junB , junD , and c fos ( but not FosB or Fra 1 ) . ^^^ Supershift analysis in the presence of antibodies to c Jun , c Fos , JunD , and JunB suggested that AP 1 complexes were composed of c Fos , JunB , and possibly c Jun . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Gel shift analyses revealed that c Jun , JunD , and c Fos bound to the TRE 2 region and that the p2672CAT activity level was elevated by co transfection with c Jun and c Fos or with JunD and c Fos expression vectors . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In the present study , we investigated the expression pattern of the inducible transcription factors ( ITF ) c Fos , c Jun , JunB , JunD , and Krox 24 following intracerebroventricular injections of hyperosmolar saline ( 0 . 2 , 0 . 3 , and 0 . 6 M NaCl ) and its mediation via angiotensin and / or muscarinic receptors . c Fos , c Jun , and Krox 24 were differentially expressed in organum vasculosum laminae terminalis , median preoptic area , subfornical organ ( SFO ) , and paraventricular and supraoptic nuclei . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Specific antibodies were used to confirm that the OA induced complex is related to AP 1 and to show that it contains JunD and c fos , but not Pit 1 . ^^^ The increase in AP 1 binding to P 1 and to a canonical AP 1 site correlates to an increase in cellular JunD and c fos content . ^^^ Our results demonstrate that a member of the AP 1 family , containing JunD and c fos , can bind to the proximal element P 1 within the hPRL promoter . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Other immediate early response genes , c fos and junB , were also induced following glucose stimulation with kinetics similar to egr 1 , whereas c jun and junD expression were not affected . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Furthermore , when components of AP 1 factors were overexpressed by transfecting Y 1 cells with their expression vectors , a paired expression of AP 1 components such as c Jun and c Fos , which were inducible by corticotropin , transactivated the CYP11B1 promoter more strongly in the absence of corticotropin than other combinations such as JunD and Fra 2 expressed constitutively . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift analysis revealed H2O2 as well as TNFalpha induced AP 1 complexes containing c Fos and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
After castration an AP 1 complex accumulated in the prostate of Fos deficient mice which mainly consists of FosB , Fra 2 and JunD whereas in control animals the AP 1 complex in addition contained c Fos . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Therefore , we determined the spatial and temporal relationships between rod morphological and functional development , rod specific gene expression , and expression of the bZIP transcription factors c fos , junD and Nrl . ^^^ The expression of opsin , beta PDE , c fos , junD and Nrl mRNAs were determined by Northern blot analysis . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
There were significant increases in JunD mRNA and protein in DFMO treated cells , although expression of the c fos , c jun , and junB genes decreased . ^^^ The increased AP 1 complexes in polyamine deficient cells were dramatically supershifted by the anti JunD antibody but not by antibodies against c Jun , JunB , or Fos proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
AP 1 binding activity , consisting of c Jun , JunD , c Fos and Fra 2 proteins , was increased in Caco 2 cells at 3 days postconfluency , a time point associated with G 1 block and cessation of proliferation . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The cell death process is accompanied by induction of JunB , c Jun , JunD and Fos proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
These downstream regulatory elements , termed DSE , can bind c Fos and JunD and transmit protein kinase C activation signals to the HIV LTR . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
H2O2 preferentially induced the expression of c fos , c jun , c myc and egr 1 , while JunB and JunD levels remained almost unchanged . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
However , a more direct approach , investigating expression of putative hibernation responsive genes by Northern analysis , revealed an increase in expression of transcription factors c fos , junB , and c Jun , but not junD , commencing during late torpor and peaking during the arousal phase of individual hibernation bouts . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The presence of several transcription factor proteins , including JunB , JunD , c Fos , Fra 1 , CREB 1 , activating transcription factor 2 , NF KB p 50 , p 52 , and p 65 , and CAAT / enhancer binding protein delta , was demonstrated by supershift analysis . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra 1 , Fra 2 , and c Fos bound to AP 1 but that prior treatment of the cells with TGFbeta reduced dramatically c Fos binding , suggesting that c Fos might be playing a negative regulatory role in clusterin gene expression . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The dsyplastic epithelium showed positive labelling for c Fos , Fra 2 , c Jun , and JunD throughout its thickness . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Constitutive urokinase receptor expression in HCT 116 cells required an intact AP 1 motif in the promoter ( at 184 ) and electrophoretic mobility shifting assays indicated less c Jun , JunD , c Fos and Fra 1 bound to this motif in the K Ras disrupted cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^ For c jun , junB , c fos and fra 2 , a relatively uniform expression pattern without significant differences among tumors was observed . junD protein amounts varied strongly in the tumor specimens . fosB expression levels also varied strongly in the tumors , weak / absent expression being found in 47 % , while 45 % exhibited strong / very strong levels of expression . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Here we show that CHOP interacts with members of the immediate early response , growth promoting AP 1 transcription factor family , JunD , c Jun , and c Fos , to activate promoter elements in the somatostatin , JunD , and collagenase genes . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts indicated that the AP 1 complex consists of c Jun , c Fos , JunD , and possibly JunB proteins , and that the NF kappaB complex contains p 50 , p 65 , and c Rel proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Gel shift analysis in the presence of specific antibodies to c Jun , JunB , JunD , c Fos , and CREB / ATF showed that the AP 1 complexes were probably c Jun / c Jun , c Fos / c Jun , c Fos / JunB , or c Jun / JunB dimers . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
PACAP potently stimulated the expression of c fos , fosB junB and junD , but not c jun mRNAs , at doses of 0 . 1 10 nM , as revealed by Northern blot analysis . ^^^ PACAP administration induced maximum expression of c fos , fosB and junB mRNA after 60 min , and of junD mRNA after 8 h . ^^^ Gel shift and supershift analyses showed that the TRE binding factors and CRE binding factors comprised fosB , c fos , junB , and junD , and CRE binding protein ( CREB ) and junD , respectively . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Significantly lower DNA binding and protein expression of JunD were detected in P cells than in P+ cells . c Jun was detected in P+ , but not P , AP 1 DNA complexes , and c Fos was detected in P , but not P+ , AP 1 DNA complexes . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The primary components present in this TGFbeta stimulated AP 1 complex are JunD and Fra 2 , although c Jun , and possibly Fos B , may also be present . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The AP 1 complex induced by DCA consisted of JunD , Fra 1 , and c Fos . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Interestingly , this complex was not affected by the addition of any antibodies against ER , c Jun , c Fos , JunB , or JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In addition , AA also increased several AP 1 proteins , such as c Fos , Fra 1 , Fra 2 , JunB , JunD , and c Jun , or AP 1 and ENKCRE 2 DNA binding activity . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP 1 site by c Jun , JunB , JunD , c Fos , FosB , and Fra 2 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In contrast , the expression of JunB , c jun and c fos , but not JunD , was increased by LPS , TNF alpha , IFN gamma and IL 1 , albeit with different kinetics and magnitude of induction . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The activator protein 1 complex in human keratinocytes consists of dimers of Fra 1 , Fra 2 , c Jun , JunD , and c Fos . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Whilst the expression of JunD was not affected by any of the mediators , the mRNA levels of c fos and JunB were induced by LPS , IL 6 , IFN gamma , PDGF and TNF alpha , and that of c jun by LPS , IFN gamma , PDGF and TNF alpha . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^ After Western blot analysis , we found significant associations between members of both groups : whereas c jun was associated with Rb expression ( p = 0 . 002 ) , strong junD and c fos expression correlated with high cyclin E reactivity ( p = 0 . 017 and p = 0 . 013 , respectively ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We found that expression of c Fos , c Jun , and JunB was induced upon LIF treatment whereas that of JunD , the tyrosine phosphatase ESP , and the components of the LIF receptor remained unaffected . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
VBP does not heterodimerize with B ZIP domains from C / EBP alpha , JUND , or FOS . ^^^ A VBP abolishes DNA binding of VBP in an equimolar competition assay , but does not affect DNA binding even at 100 fold excess of CREB , C / EBP alpha , or FOS / JUND . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift analysis suggests that activated AP 1 contained c Jun , JunD , c Fos , FosB , and Fra 1 subunits . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We show here that ( 1 ) 5 Jun mediated repression of the endogenous SPARC gene is enhanced by Fra 2 but alleviated by ATF 2 , Fra 2 and ATF 2 being the two major partners of 5 Jun in the transformed cells ; ( 2 ) high basal activity as well as repression by 5 Jun and modulation by Fra 2 and ATF 2 is restricted to a small proximal fragment ( 124 / +16 ) of the chicken SPARC promoter ; ( 3 ) the activity of this minimal promoter is modulated by all the AP 1 family members known in chickens ( c Jun and JunD ; c Fos and Fra 2 ; ATF 2 ; c Maf , MafA , and MafB ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift assays demonstrated that JunD and c Fos were present in the protein DNA complexes under control and hyperglycemic conditions . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Of major significance was the finding that FosB could be detected as a component of AP 1 in 7 DIV cells only under excitotoxic conditions , whereas c Fos , Fra 2 , and JunD proteins were detectable under both excitotoxic and nontoxic conditions in cells of this age . ^^^ Because Fos family members are unable to form homodimers , this finding raises the possibility that the FosB / JunD heterodimer may have special significance in the mechanism of excitotoxic neuronal death . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We previously showed that Tax induces the expression of various family members of the transcription factor AP 1 such as c Jun , JunD , c Fos , and Fra 1 at the mRNA level in T cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
While c Fos , Fra 2 and JunB were increased in response to either stimuli , only Fra 1 , c Jun and JunD were increased by PMA . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Human T cell leukemia virus type 1 ( HTLV 1 ) Tax protein induces the expression of various family members of the transcription factor AP 1 , such as c Jun , JunD , c Fos , and Fra 1 , at the level of RNA expression in T cells . ^^^ Activation of transcription through the AP 1 site in Jurkat cells by JunD and / or Fra 2 was weak . c Jun , JunB , and c Fos activation was greater , although the level was still less than that with Tax . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The only other member of the Fos Jun family expressed in differentiated 3T3 L 1 cells was JunD and a complex of Fra 1 and JunD was formed on a consensus AP 1 binding element in differentiated 3T3 L 1 cells , suggesting that the complex of Fra 1 and JunD may play a role in the stimulation of the differentiation process of 3T3 L 1 cells observed after treatment of the cells with insulin sensitizers . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In this study , we used expression vectors for wild type , dominant negative , and forced homodimeric ( Jun / eb1 chimeric factors ) forms of JunD and other Fos and Jun proteins to determine the requirement for JunD in the transcriptional regulation of the TIMP 1 and interleukin 6 ( IL 6 ) genes . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Using knock out strategies it was found that some components , such as c Fos , FosB and JunD are dispensable , whereas others , like c Jun , JunB and Fra 1 are essential in embryonic development and / or in the adult organism . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
This process is dependent on the induction of the transcription factor AP 1 , a dimeric complex composed of c Fos and c Jun / JunD phosphoproteins . ^^^ While c Fos is essential , JunD is dispensable for light induced photoreceptor apoptosis . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift experiments and Western blots confirmed that the binding of c Fos , JunB , and JunD , but not of FosB , was reduced in anergized cells . ^^^ Anergy is accompanied by a reduction in AP 1 binding to the IL 2 promoter , with selective reduction in binding of c Fos , JunB , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In hippocampus of young , aged unimpaired and aged impaired rats , AP 1 consists mainly of c Jun , phosphorylated c Jun ( p c Jun ) , JunD , and smaller amounts of c Fos . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
A weak C fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c Fos , FosB , Krox 20 or Krox 24 ; but it did reduce the basal expressions of c Jun and JunD in both the medial and lateral areas . ^^^ With repeated stimulation , i . e . when the noxious stimulus was applied to the contralateral hindpaw 6 h after the sciatic stimulation , there was again no induction of c Fos , FosB or Krox 20 in the medial thalamus ; but there was an increase in c Jun and Krox 24 , and a decrease in JunD levels . ^^^ In the lateral thalamus the repeated stimulation again failed to induce c Fos , but the expressions of FosB , c Jun and Krox 24 were increased , and that of JunD was again reduced . ^^^ With coincident stimulation , i . e . when a stimulus was applied to each hindpaw simultaneously , c Fos and Krox 24 remained absent ; but there was a marked induction of FosB and Krox 20 , a strong repression of c Jun , and no effect or a reduction of the basal levels of JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Antibody electrophoretic mobility shift assays showed that JunD and c Fos binding is found in cells treated with porins , in cells treated with LPS , and in unstimulated cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Forty six globes were processed for in situ hybridization with oligonucleotide probes for c fos , fosB , c jun , junB and junD mRNAs , and 60 globes were immunohistochemically analysed using anti c Fos and anti c Jun antibodies . ^^^ Normal lens epithelial cells expressed mRNA signals for junD , but not for c fos , fosB , c jun , and junB . mRNAs for c fos , fosB , c jun , and junB were detected in the whole lens epithelium from the vicinity to the wound to the equator from 30 min to 8 hr post injury with their peaks after 30 min to 1 hr , but were no longer detected at 10 hr or later . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The DNA binding activities of c Fos , FosB / Delta FosB , Fra 1 , Fra 2 , and JunB were up regulated whereas JunD activity was decreased . c Fos , FosB / Delta FosB , and JunB were associated with Smad 4 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Indeed , this element was recognized by c Fos and JunD in vitro , and mutation or deletion of this element reduced the early response to serum stimulation by 60 % . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We observed that withdrawal of IL 7 induced increased expression of jun and fos family member genes including c jun , junB , junD , c fos and fra 2 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We have characterized the effects of chronic clozapine and haloperidol treatments on the expression of fos ( c fos , fosB , fra 2 ) and jun ( c jun , junB , junD ) family genes in the rat forebrain . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
JunD , a member of the Jun family of nuclear transcription proteins , dimerizes with Fos family members or other Jun proteins ( c Jun or JunB ) to form the activator protein 1 ( AP 1 ) transcription factor . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We found that the zinc finger region of BCL 6 interacts with c Jun , JunB , and JunD proteins but does not bind c Fos or Fra 2 proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Supershift EMSA revealed that VT preferentially induced JunB , JunD , phosphorylated c Jun , c Fos , and Fra 2 binding activities of the AP 1 family . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
This element appeared to preferentially interact with a c fos / JunD heterodimer . ^^^ Stimulation by EGF induced the binding of c fos and JunD to this element and subsequently elevated promoter activity . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Gene disruption studies indicate that the AP 1 family members c jun , junB , and fra 1 are essential for embryonic development , whereas junD , c fos , and fosB are required for normal postnatal growth . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We demonstrated that c Fos , c Jun , and JunD are involved in TPA inhibitory effect due to their ability to bind TRE ALAS , evidenced by supershift analysis and their capacity to repress promoter activity in transfection assays . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Phosphorylated c Jun , JunB , JunD , and Fra 1 , but not c Fos , FosB , or ATF 2 , are detected in the AP 1 DNA binding complex in cells exposed to trivalent arsenicals . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Menin did not alter the expression levels of AP 1 proteins except c Fos , phosphorylation of c Jun and JunD and DNA binding properties of AP 1 proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
We report that the promoter proximal activator protein 1 ( AP 1 ) site is essential for the response of both Timp 1 and MMP 1 to TGF beta ( induction and repression , respectively ) . c Fos , JunD , and c Jun are essential for the induction of Timp 1 gene expression by TGF beta 1 , but these AP 1 factors transactivate equally well from both Timp 1 and MMP 1 AP 1 sites . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Based on in vitro analyses , GnRH appeared to enhance the interaction of JunD , FosB , and c Fos at the GnRHR AP 1 element . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^ Nuclear extracts from granulosa cells from 1 2 mm or 8 10 mm antral follicles bound an AP 1 DNA consensus sequence and complexes consisted predominantly of c Jun , JunD , JunB , c Fos , and Fra 2 . ^^^ In CL , c Jun , JunD , JunB , and Fra 2 were present in DNA binding complexes , and c Fos binding was not detected . ^^^ Differentiation to the luteal phenotype involves a reduction in nuclear c Jun and c Fos and a predominance of JunD and Fra 2 . . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Among the early response genes analyzed , c myc , junB , junD , c jun , c fos , fosB , fra , as well as max , mad 1 4 , sin 3 , only c jun and fra 2 mRNAs were up regulated after 1 , 25 ( OH ) ( 2 ) D ( 3 ) exposure . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The JNK deficient cells exhibited decreased expression of c Jun , JunD , c Fos , Fra 1 , and Fra 2 ; decreased phosphorylation of c Jun and JunD ; and decreased AP 1 DNA binding activity . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Of the AP 1 proteins studied , c Jun was expressed at the highest level , followed by JunD , c Fos , and Fra 2 , although different treatments induced slightly different levels of expression . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The same PKCepsilon inhibitors blocked S1P evoked increases in T cell nuclear levels of c Fos and phosphorylated c Jun and JunD after 24 h , but not 1 h . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Here , the major cis regulatory elements that control IFN gamma inducible NOS 2 gene transcription in human lung epithelial cells are identified as composite response elements that bind signal transducer and activator of transcription 1 ( STAT 1 ) and activator protein 1 ( AP 1 ) , which is comprised of c Fos , Fra 2 , c Jun , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In a Gal 4 fusion assay , Pdcd 4 specifically inhibited activation of c Jun and c Fos activation domains , but did not inhibit activation of JunB , JunD , Fra 1 , or Fra 2 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Electrophoretic mobility supershift assay indicated that the JunB , JunD , and c Fos components of AP 1 were particularly affected . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Using specific polyclonal antisera against c Fos , JunB , c Jun and JunD , we tried to identify the candidate transcription factors of the immediate early gene family which may contribute to the molecular processes during contextual memory reconsolidation . ^^^ In these mice context dependent memory retrieval evoked a marked induction of c Fos and JunB , but not of c Jun and JunD , in pyramidal CA 1 neurons of the dorsal hippocampus . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Here we surveyed human lymphoma samples for expression of JunB and other AP 1 members ( c Jun , c Fos , Fra 1 , JunD ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In the current study , we examined the expression of seven fos / jun family member mRNAs ( c fos , fosB , fos related antigen ( fra ) 1 , fra 2 , junB , c jun , and junD ) and three other IEG mRNAs ( egr 1 , egr 3 , and nur 77 ) in mouse brain following short term ( 6 h ) sleep deprivation ( SD ) and 4 h recovery sleep ( RS ) after SD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Among Jun / Fos proteins , only JunD and c Fos are abundantly expressed in neutrophils , and they are mainly cytoplasmic . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) binding to DNA increased more in VSMC from old versus young rats ( P < 0 . 02 ) and was related to increased expression of its components , c Fos , Fra 1 , and JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In situ hybridization was used to evaluate depolarization thresholds for induction of mRNAs encoding the 70 kDa heat shock / stress protein , hsp 72 , as well as several immediate early genes ( c fos , c jun , junB , and junD ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In adult mice , all seven Jun and Fos family members constituting the AP 1 complex were expressed more abundantly in the female gland than in the male gland , and JunD was the most abundant of the members . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The c Jun , c Fos and JunD proteins were detected in the Sertoli cell nuclei , whereas apoptosis occurred in the germ cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Constitutive expression of the AP 1 transcription factors c jun , junD , junB , and c fos and the marginal zone B cell transcription factor Notch 2 in splenic marginal zone lymphoma . ^^^ The AP 1 transcription factors c jun , junD , junB , and c fos as well as Notch 2 were found to be specifically up regulated . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Expression levels of activator protein 1 family members ( c jun , junB , junD , and c fos ) and transforming growth factor ( TGF ) alpha were significantly lower in TPA treated Smad 3 ( / ) skin , cultured keratinocytes , and papillomas , as compared with Smad 3 ( + / + ) controls . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
HTLV 1 encoded Tax elevates AP 1 activity through the induction of AP 1 family member gene expression , including c Jun , JunD , c Fos , and Fra 1 . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Cluster analysis of ECL cell enriched samples demonstrated that c fos and junD were differently regulated . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Transfection with c Jun or JunB had no effect on transcription from the Cx 43 promoter , whereas transfection with JunD or combinations of Jun and Fos family members led to significant increases in transcription . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
AP 1 DNA binding activity consists primarily of JunD , c Fos , and Fra 1 , and is accompanied with the increased expression and phosphorylation of these subunits . ^^^ While inhibition of JNK mainly prevents expression and phosphorylation of JunD and c Jun , inhibition of the ERK pathway suppresses both phosphorylation and expression of Jun proteins , and expression of c Fos and Fra 1 . ^^^ Conversely , coexpression of JunD or c Jun and c Fos can induce alpha2beta1 integrin expression independently of upstream signals . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Heat shock protein 90 is required for increased DNA binding activity of activator protein 1 , a heterodimer of Fos / JunD , in rheumatoid synovial cells under inflammatory stimuli . ^^^ Upon stimulation with inflammatory cytokines IL 1beta or TNFalpha , the AP 1 binding activity was further increased in rheumatoid synovial cells , and increased AP 1 protein was composed as heterodimers of Fos and JunD which was not known before as a major component of AP 1 in rheumatoid synovial cells . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Expression levels of JunD and c Fos were high in nonneoplastic colorectal epithelial cells and remained so in neoplasms . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 induced the nuclear transcription factor activator protein 1 family , including the c Jun , JunD , c Fos , FosB , and Fra 1 proteins . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Neither c Fos nor JunD or FosB mRNA differed between tumours and normal tissues . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The combination of c Fos and c Jun or c Fos and JunD strongly suppresses hTERT promoter activity in transient expression analyses . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Ischemia induced the expression and binding of c Fos , c Jun , JunB , FosB , and Fra 2 to a noncanonical activating protein 1 ( AP 1 ) site present in the MMP 2 promoter and decreased binding of the transcriptional repressor JunD . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The AP 1 DNA binding complex in control and ethanol treated nuclear extract was composed of c Fos , FosB , c Jun , JunD , and phosphorylated CREB ( p CREB ) . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Subgroup analysis showed tumor specific binding for c Fos in 58 % , for c Jun in 50 % , for JunD in 39 % , and for Fra 1 in 4 % of cases . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
The Jun proteins Jun , JunB and JunD are core members of activator protein 1 ( AP 1 ) , a dimeric transcription factor complex consisting of homo and heterodimers of the Jun , Fos , activating transcription factor ( ATF ) and musculoaponeurotic fibrosarcoma ( Maf ) families . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Furthermore , almost all kinds of the AP 1 family genes including c jun , c fos , junD , junB , atf 2 and b atf were successfully selected from an mRNA display library constructed from a mouse brain poly A ( + ) RNA after six rounds of selection . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
Further , in contrast to the JunD and Fra 2 components present in the AP 1 complex at this AP 1 site in UECs , c Fos was the major detectable AP 1 component in HCCCs . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
In addition , hnRNP G overexpression led to up regulation of the expression of TXNIP , a cell cycle inhibitory gene , and significantly reduced the expression of the genes that promote cellular proliferation , such as EGR 1 , JUND , JUNB , FOS , FOSL 1 , ROS , and KIT . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17535 and P01100	Pubmed	SVM Score :0.0
NA