Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The fos related antigen 2 ( fra 2 ) gene is the most recently described member of the Fos family . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Fos B , FRA 1 , FRA 2 , Jun B , Jun D , NGFI A ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The upper or basal complex also includes c Fos , Fra 2 , Ets 2 , and Oct 1 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Using these cells , we show that activation of MEK leads to the expression of Fra 1 and Fra 2 but not c Fos . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Likewise , the immediate early genes encoding c Fos , FosB , and Fra 2 are repressed in these cells . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The activator protein 1 complex in human keratinocytes consists of dimers of Fra 1 , Fra 2 , c Jun , JunD , and c Fos . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Furthermore , no Fra 2 , Fos B or c Jun immunoreactivities were detected in these same synaptic regions . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
JunB , c Jun , c Fos , and Fra 2 were rapidly but transiently induced by FSH in immature granulosa cells . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Fra 2 , c Fos , and Fos B were relatively unchanged by vinblastine . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
A similar activation pattern was seen for c Fos but not for Fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
UVA irradiation induced protein expression of c Fos , c Jun , Fra 1 and Fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Regulated expression of immediate early genes c fos , fra 2 and junB was observed in the transgenic mice . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In addition , G 120 increased the expression of c Jun , Fra 1 , and Fra 2 , but did not affect the expression of c Fos . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Amongst all Fos and Jun family members examined , only were the levels of c Jun and Fra 2 consistently elevated by the ITCs . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In this report , we have extended the analysis of one member of this family , fos related antigen 2 ( fra 2 ) , by isolating and characterising genomic and cDNA clones encoding the mouse fra 2 homolog . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Numerous cellular and viral genes contain AP 1 binding sites within their promoters and , accordingly , AP 1 has been shown to play a role in the regulation of both basal and inducible transcription of these genes . fos related antigen 2 ( fra 2 ) has been found to have both similar and unique properties to that of other fos gene members in terms of its regulation and expression . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Chromosomal assignment of the human gene encoding the Fos related antigen 2 ( FRA 2 ) to chromosome 2p22 p 23 . ^^^ When studying cAMP induced apoptosis in a leukemia cell line from rat , we found that the Fra 2 gene ( coding for the Fos related antigen 2 ) became strongly upregulated as the leukemia cells started to die . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
To the best of the authors ' knowledge , this is the first report that GES 1 cells infected with spiral H . pylori have higher expression of cxcl 10 , ccl 11 , ccl 5 , groalpha , TLR 5 , ATF 3 , fos , fosl 2 , gadd45a and myc . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Carbachol and thrombin have similar effects on expression of c fos , fosB , fra 2 , junB , and junD , both acutely and over a 24 h time course . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We have shown that while c Fos is the major Fos protein associated with the Jun proteins ( c Jun , JunB , and JunD ) soon after serum stimulation , at later times Fra 1 and Fra 2 are the predominant Fos proteins associated with the different Jun proteins . ^^^ During exponential growth , the synthesis of Fra 1 and Fra 2 is maintained at a significant level , in contrast to c Fos and FosB , which are expressed at very low or undetectable levels . ^^^ To determine whether the Fos proteins are differentially required during the G 0 to G 1 transition and exponential growth for the entrance into S phase , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , and Fra 2 . ^^^ We have found that while the activities of c Fos and FosB are required mostly during the G 0 to G 1 transition , Fra 1 and Fra 2 are involved both in the G 0 to G 1 transition and in asynchronous growth . . ^^^ Consequently , Fra 1 and Fra 2 are the main Fos proteins complexed with the Jun proteins in asynchronously growing cells . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Compared with c fos mRNA , expression of these fra 2 mRNAs was significantly prolonged , in good agreement with the previous analysis on the synthetic rate of Fos and Fra 2 proteins . ^^^ The RNA transcript and the gene product of a newly isolated fos related gene , fra 2 , were analyzed in growth arrested and growth stimulated chicken embryo fibroblasts ( CEF ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The expression of Fra 2 , one of the recently isolated Fos related antigens , but not Fos was detected in both JH 1 infected CEF and CEF infected with the control retrovirus vector ( DS 3 ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Difference in transcriptional regulatory function between c Fos and Fra 2 . ^^^ Fra 2 , one of the Fos related antigens , is promptly expressed after the growth stimulation of fibroblasts , but its induction peak is later than that of c Fos . ^^^ In this report , we examined biochemical properties of Fra 2 and compared them with those of two other Fos family proteins , c Fos and Fra 1 . ^^^ Like c Fos and Fra 1 , Fra 2 formed stable heterodimers with c Jun , JunB or JunD in vitro and all these complexes had specific DNA binding activity to AP 1 binding sites ( AP 1 sites ) or related sequences . ^^^ This property of Fra 2 is in clear contrast to that of c Fos , which stimulates the transcriptional activity of c Jun by forming a stable heterodimer . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Isolation of human fos related genes and their expression during monocyte macrophage differentiation . cDNA clones of human fos related genes fra 1 and fra 2 were isolated by screening human c DNA libraries with human fos DNA as a probe . ^^^ A new fos related gene , fra 2 , has one long open reading frame of 326 amino acids , and can code for a protein with a calculated molecular weight of 35 , 193 . ^^^ Transcription of the fos , fra 1 and fra 2 genes was induced by phorbol ester ( TPA ) stimulation of U 937 human monocytic cells . ^^^ On TPA stimulation , the transcriptions of fos , fra 1 and fra 2 were detectable after 30 , 60 and 120 min and maximum after 60 , 90 and 240 min , respectively . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The fra 2 gene product formed a complex in cells with the c Jun protein , indicating that c fos and fra 2 share biological and biochemical functions . . ^^^ Isolation and characterization of fra 2 , an additional member of the fos gene family . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The Fos family of proteins now includes seven members : the retroviral proteins FBR 5 Fos and FBJ 5 Fos and the cellular proteins c Fos , FosB , FosB 2 , Fra 1 , and Fra 2 . ^^^ Four proteins ( FBR 5 Fos , FBJ 5 Fos , c Fos , and FosB ) transform established rodent fibroblast cell lines , while three ( FosB 2 , Fra 1 , and Fra 2 ) do not . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Studies are presented that indicate this 42 / 46 kDa Fra is Fra 2 , a poorly understood member of the Fos family of transcription factors . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Like c fos , fra 2 was inducible by phorbol ester , cAMP and calcium ionophore , as well as serum . ^^^ In all three cases , the induction of two species of fra 2 transcript ( 5 . 7 kb and 6 . 8 kb ) was delayed and prolonged compared with that of c fos mRNA . ^^^ In the fra 2 promoter region , which is located in a typical CpG island , enhancer consensus sequences such as SCM , SRE , GC boxes and CRE like sequences were detected upstream of the TATA like sequence in the same order as that in the 5 ' upstream region of the chicken c fos gene . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The fra 2 gene is related to the proto oncogene c fos and encodes a member of the AP 1 transcription factor gene family . ^^^ Tissue specific expression of the fos related transcription factor fra 2 during mouse development . ^^^ We have studied the expression of fra 2 during mouse embryonic development and compared it to the pattern of expression of other fos and jun family members . ^^^ The pattern of fra 2 expression is distinct from that observed for other fos related genes , suggesting that fra 2 has a unique role in cellular differentiation during fetal development . . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Our findings demonstrate high levels of c fos , c jun , and jun B mRNA transcripts during the proliferative period of osteoblast development , while expression of fra 1 and fra 2 is enhanced during the differentiation period . jun D is constitutively expressed during the time course exhibiting only a 30 % decline in levels postproliferatively , and fos B mRNA is undetectable by Northern blot analyses . ^^^ At this time , fra 1 expression is completely downregulated , while c fos , fra 2 , c jun , jun B , and jun D show a dramatic enhancement in expression . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Antibodies to fra 2 , a fos family member , and to the p 50 , but not the p 65 , subunit of NF kappa B supershift the Mod 1 complex . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
BHQ induced expression of c jun , junB , fra 1 , and fra 2 , which encode AP 1 components , but was a poor inducer of c fos and had no effect on fosB . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Antibodies specific for either c Jun or the Fos family ( c Fos , Fos B , Fra 1 , and Fra 2 ) protected NGF deprived neurons from apoptosis , whereas antibodies specific for Jun B , Jun D , or three nonimmune antibody preparations had no protective effect . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The time course of the induction of NGFI A , NGFI B , fra 2 and TIS 11 was similar to that previously observed with c fos and the members of the jun family . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Two and six hours after the treatment , AP 1 consisted predominantly of Fos B , c Fos , Fra 2 and Jun B , while at 72 h Jun D constituted the major AP 1 component in place of Jun B , and no c Fos was detected . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In growth arrested CEF , small amounts of Fra 2 / c Jun complex bind to the AP 1 consensus sequences in fra 2 promoter , while a significant part of the enhanced AP 1 binding activity after 60 120 min of serum stimulation is attributable to c Fos / c Jun heterodimer . ^^^ Transient expression assays in F 9 cells indicated that c Fos / c Jun heterodimers have strong stimulatory effects on fra 2 promoter activity , while Fra 2 / c Jun complex has lower transcriptional activity than that of c Jun homodimer . ^^^ These results suggest that c Fos ( induced at earlier times ) and c Jun proteins are at least partly responsible for serum induced expression of fra 2 . . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The Fos family of transcription factors , c Fos , FosB , Fra 1 and Fra 2 , are rapidly induced in quiescent fibroblasts following serum or growth factor stimulation . ^^^ The Fos proteins show distinct patterns of expression during cell growth with only Fra 1 and Fra 2 maintained at significant levels in growing cells , suggesting that the different family members direct unique functions for cell growth . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
FOS and JUN proteins are induced by ACTH independently of cell cycle stage . c Fos , fos B , fra 1 , fra 2 , c jun , and jun B genes are induced by ACTH , the kinetic profiles for mRNAs and respective protein products being similar , except for a 1 h protein delay . ^^^ FOS and JUN proteins are induced by ACTH independently of cell cycle stage . c Fos , fos B , fra 1 , fra 2 , c jun , and jun B genes are induced by ACTH , the kinetic profiles for mRNAs and respective protein products being similar , except for a 1 h protein delay . ^^^ On the other hand , cAMP derivatives are not effective in inducing the fos and jun genes , except for fra 2 mRNA , JUN D protein , and to some extent JUN B protein . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
FRA 2 , which is a c FOS related protein , is resistant to micro but not to milli calpain whereas FRA 1 , another member of the fos family , is resistant to both proteases . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Fos like immunoreactivity observed in the left atrium was accompanied by elevated mRNA levels of fra 1 and fra 2 but not c fos itself indicating that a related gene product other than Fos contributed to the observed response . ^^^ Fos like immunoreactivity observed in the left atrium was accompanied by elevated mRNA levels of fra 1 and fra 2 but not c fos itself indicating that a related gene product other than Fos contributed to the observed response . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Conversely , JE gene mRNA accumulates progressively in estrogen stimulated uterine cells , whereas TIS 11 and 21 genes are only slightly responsive to the hormone ( less than twofold induction ) and fos B , fra 1 , fra 2 , krox 20 ( egr 2 ) , TIS 7 and 10 , KC , and c rel mRNAs are undetectable in rat uterus either before or after estrogen treatment . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The Fos related proteins Fra 1 and Fra 2 bent DNA in the same orientation as Fos but induced smaller DNA bend angles . ^^^ ATF 2 also bent DNA toward the minor groove in heterodimers formed with Fos , Fra 2 , and Jun . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Fos B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglia . c fos mRNA also changes ; these differences contrast with the lack of significant changes in the low basal levels of expression of fra 1 and fra 2 mRNAs . ^^^ Fos B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglia . c fos mRNA also changes ; these differences contrast with the lack of significant changes in the low basal levels of expression of fra 1 and fra 2 mRNAs . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Using a seasonal breeder , the European red fox ( Vulpes vulpes ) , as our model , we have examined the expression of five AP 1 family members ( c fos , fra 1 , fra 2 , c jun and junB ) with a view to elucidating their role in the regulation of spermatogenesis . ^^^ Unique patterns of expression , falling into three broad categories , were observed for the five genes : ( 1 ) continuous expression throughout the spermatogenic cycle ( c fos ) ; ( 2 ) expression only at times corresponding to the onset and shutdown of spermatogenesis ( fra 1 , fra 2 and c jun ) ; and ( 3 ) expression only at the onset of the cycle ( junB ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
This proliferative defect is associated with the markedly reduced induction of c jun , c fos , Fra 2 and FosB following activation of the CREBA 119 transgenic thymocytes . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Using in situ hybridization , the expression of c fos , fosB , fra 1 , fra 2 , c jun and junB was studied after 15 min of normothermic and hypothermic ( 33 degrees C ) transient forebrain ischaemia in the rat , induced by common carotid occlusion combined with systemic hypotension . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Withdrawal studies demonstrated robust induction of several known acute Fras , including c Fos , FosB , Fra 1 , Fra 2 , and delta FosB , at 6 hr after naltrexone precipitation of withdrawal in the striatum , nucleus accumbens , and several other brain regions . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In vitro gel mobility shift and competition assays using wild type and mutated oligonucleotides and antibodies indicate that Fra 2 , a Fos related transcription factor , binds to this motif . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Calcium induced AP 1 DNA binding complexes consist of Fra 1 , Fra 2 , c Jun , JunB and JunD and are independent of c Fos , since the induction of DNA binding activity and the composition of the AP 1 binding complexes are identical in differentiating keratinocytes derived from c fos null and wild type mice . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The AP 1 protein complex at 21 days postnatally was composed of JunD , JunB , Fra 2 , FosB and to much lesser extent of c Fos in both cortical areas . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Two activator protein 1 elements in the matrix metalloproteinase 1 promoter have different effects on transcription and bind Jun D , c Fos , and Fra 2 . ^^^ DNA / protein complexes at both AP 1 sites contain c Fos and Jun D proteins , while Fra 2 is present only at the 77 site . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We observed that : ( a ) c jun mRNA expression is upregulated predominantly by UVB ; ( b ) fra 1 and c myc are downregulated by UVB , whereas both are upregulated by UVA ; ( c ) fra 2 and AP 2 are downregulated modestly by UVB , ( d ) c fos is unaffected , and ( e ) optimal regulation of each gene is achieved at environmentally relevant fluences ( 25 100 J / m2 for UVB and 2500 10 000 J / m2 for UVA ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation : role of Fra 2 and Jun D during differentiation . ^^^ All Fos and Jun family members are involved in AP 1 complex formation in proliferating cells , whereas Fra 2 and Jun D predominate in AP 1 complexes in differentiated osteoblasts . ^^^ Coexpression of only one AP 1 pair , Fra 2 and Jun D , stimulated reporter expression , whereas coexpression of other AP 1 pairs down regulated expression ( i . e . c jun and any Fos family member ) or had no effect ( i . e . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^ In HeLa cells , the complex consisted predominantly of c Jun and the Fos family members FosB and Fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In both 308 and 10Gy5 cells , c fos , fra 2 , c jun , jun B , and jun D were capable of binding to an AP 1 DNA binding site as determined by antibody clearance gel mobility shift assays . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Expression of genes for all the other known members of chicken AP 1 , which include such transforming genes as c jun and fra 2 , however , caused no macroscopic abnormalities in limb formation , indicating a specific function of Fos proteins in embryonic endochondral bone differentiation . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
All the known components of chicken AP 1 ( c Fos , Fra 2 , c Jun , and JunD ) were detected in both cell types , but the expression level of c Jun was much higher in LS cells , which are rich in less mature chondrocytes than US cells . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
USF specifically interacts with Fra 1 but not with other closely related family members , c Fos , Fra 2 , FosB , or with c Jun . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The major changes in the expression levels of fos and jun family genes induced by 5 src were the elevation of fra 2 and c jun transcripts . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The pattern of IEG mRNA induction fell into three classes : IEGs that were induced in both damaged and spared areas ( c fos , fos B , jun B , and egr 1 ) , IEGs that were induced specifically in the damaged areas ( fra 2 and c jun ) , and an IEG that was significantly induced by saline injection and / or the cold treatment ( jun D ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
This TRE bound TPA induced specific nuclear complexes in vitro containing junD , c jun , c fos , and fra 2 but not cAMP responsive element binding / activating transcription factor family proteins . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The Fos related antigens Fra 1 and Fra 2 and three previously uncharacterized c Fos related proteins were additionally found in the striatum which do not increase following lesion . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Opposing activities of c Fos and Fra 2 on AP 1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters . ^^^ Analysis of AP 1 protein expression in calcium and TPA treated keratinocytes demonstrated that only TPA increased the expression of c Jun , while Jun B and Jun D were induced by both of these agents . c Fos was expressed only in TPA treated keratinocytes , Fra 2 was expressed only in calcium treated cells , and Fra 1 was expressed in both . ^^^ Exogenous expression of Fra 2 repressed AP 1 transcriptional activity in TPA treated keratinocytes , while c Fos expression activated the AP 1 sequence in calcium treated keratinocytes . ^^^ These data indicate that Fra 2 and c Fos play opposing roles in regulating AP 1 activity in keratinocytes and that multiple inducer dependent regulatory pathways may exist for the expression of keratinocyte differentiation markers . . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
TNFa increased c Jun protein , but only weakly induced FOS proteins ( c Fos , FosB , Fra 1 , and Fra 2 ) whereas cAMP increased the abundance of several FOS proteins ( c Fos , FosB , Fra 1 , and Fra 2 ) , with little effect on c Jun levels . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The effects of regular ( RNa ) or high ( HNa ) sodium diet for 3 , 7 , and 14 days on Fra like immunoreactivity ( Fra LI ) in the brains of Wistar Kyoto rats ( WKY ) and spontaneously hypertensive rats ( SHR ) were examined using an antibody that recognizes all known members of the Fos family ( Fos , Fos B , Fra 1 , and Fra 2 ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Thus , iodide decreases the formation of Mod 1 , an enhancer A complex involving the p 50 subunit of NF kappa B and a c fos family member , fra 2 , which was previously shown to be important in the suppression of class 1 levels by hydrocortisone . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^ While the fos family members were transiently upregulated 10 to 20 fold ( an exception being fra 2 ) the induction of the jun family members was up to 3 fold only . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The overexpression of 5 Rel , c Rel , and c Rel delta resulted in a prolonged elevation of c fos and c jun expression and in a sustained repression of fra 2 at both the mRNA and protein levels in fibroblasts and lymphoid cells . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The blockade of KA induced proENK and proDYN mRNA levels by the pre treatment with L ARG was well correlated with proto oncoprotein levels , such as c Fos , Fra 2 , FosB , JunD , JunB , and c Jun , as well as AP 1 and ENKCRE 2 DNA binding activities . ^^^ The pre administration with L NAME further increased KA induced c jun and c fos mRNA levels in addition to their protein product levels , although the pre treatment with L NAME did not affect KA induced FosB , Fra 2 , JunB , and JunD protein levels at 6 h after treatment . ^^^ Our results suggest that L ARG plays an important role in inhibiting KA induced proENK or proDYN mRNA expression , and its inhibitory action may be mediated through reducing the proto oncoprotein levels , such as c Fos , Fra 2 , FosB , c Jun , JunD , and JunB . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Expression of c jun , junB , c fos , fra 1 and fra 2 mRNA in the rat brain following seizure activity and axotomy . ^^^ The patterns of c jun , junB , c fos , fra 1 and fra 2 mRNAs were studied by radioactive and non radioactive in situ hybridization in the adult rat brain following kainate induced seizure activity and axotomy . ^^^ Whereas fra 1 and fra 2 were restricted to the hippocampus , c jun , junB and c fos were additionally induced in the cortex , amygdala and thalamus . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Blocked shift / supershift analysis indicates that Fos family member proteins especially Fra 1 and Fra 2 are related to progression and no changes found in the Jun family member proteins although they are present in the AP 1 / DNA binding complex . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Furthermore , when components of AP 1 factors were overexpressed by transfecting Y 1 cells with their expression vectors , a paired expression of AP 1 components such as c Jun and c Fos , which were inducible by corticotropin , transactivated the CYP11B1 promoter more strongly in the absence of corticotropin than other combinations such as JunD and Fra 2 expressed constitutively . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
One hour after the intraperitoneal administration of delta 9 THC at a dose of 10 or 15 mg / kg , AP 1 DNA binding activity in the nucleus accumbens increased by 33 and 49 % , respectively , while Western blot showed an increase in both c Fos , FosB , Fra 1 ( Fos related antigen ) and Fra 2 . ^^^ While in the caudate putamen the increase in AP 1 DNA binding was mainly due to an elevation of the c Fos and FosB proteins , the same phenomenon depended on the FosB , Fra 1 and Fra 2 peptides in the cingulate cortex . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In addition to the proENK mRNA level , PGE 2 also increased c Fos ( approximately 4 . 3 fold ) , Fra 1 ( approximately 3 . 8 fold ) , and Fra 2 ( approximately 8 . 2 fold ) protein levels at 4 h after drug treatment . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
After castration an AP 1 complex accumulated in the prostate of Fos deficient mice which mainly consists of FosB , Fra 2 and JunD whereas in control animals the AP 1 complex in addition contained c Fos . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The brains were processed using an antibody that recognizes Fos , FosB , Fra 1 , and Fra 2 for the detection of Fra LI and using an antibody that only recognizes Fos like immunoreactivity ( Fos LI ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We have examined the expression of members of the AP 1 transcription factor complex in response to stimulation with different doses of LPA . c Fos , c Jun , and JunB are induced rapidly in response to LPA stimulation , whereas Fra 1 and Fra 2 are induced after a significant lag . ^^^ The expression of c Fos is transient , whereas the expression of c Jun , JunB , Fra 1 , and Fra 2 is sustained . ^^^ LPA stimulated expression of c Fos , Fra 1 , Fra 2 , c Jun , and JunB is inhibited by the MEK 1 inhibitor PD 098059 , indicating that the Raf MEK MAPK cascade is required for their expression . ^^^ In cells expressing a conditionally active form of Raf 1 ( DeltaRaf 1 : ER ) , we observed that selective , sustained activation of Raf MEK MAPK was sufficient to induce expression of Fra 1 , Fra 2 , and JunB but , interestingly , induced little or no c Fos or c Jun . ^^^ However , in contrast to the case for Fra 1 , Fra 2 , and JunB , activation of the MAPK cascade alone is not sufficient to induce c Fos expression , which rather requires cooperation with other signals such as Ca2+ mobilization . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Under light stimulation , c Fos and Jun B consistently increased , as expected , but this was also the case for Fra 2 , Jun D , and c Jun , although to a lesser extent . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
AP 1 binding activity , consisting of c Jun , JunD , c Fos and Fra 2 proteins , was increased in Caco 2 cells at 3 days postconfluency , a time point associated with G 1 block and cessation of proliferation . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Supershift EMSA analysis with antibodies directed at individual AP 1 components revealed that AP 1 extracted from the brains of trained as well as naive animals is composed of the same proteins , i . e . , in order of relative level within the protein family : c Fos , Fos B , Fra 2 , and Jun D , Jun B , c Jun . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
After 2 h of aldosterone treatment , fra 2 mRNA was upregulated by 130 % , whereas c myc , c jun , c fos , and glucocorticoid receptor mRNAs were downregulated by 23 43 % . ^^^ After 16 h , c fos and GR mRNAs were further decreased , whereas levels of fra 2 , c jun , and c myc began to return to control levels . ^^^ Aldosterone action : induction of p 21 ( ras ) and fra 2 and transcription independent decrease in myc , jun , and fos . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
However , we demonstrate that DP cortical thymocytes are specifically impaired in c fos and fosB mRNA induction , even when stimuli are used that optimize survival of the cells and a form of in vitro maturation . fra 2 expression is induction independent but much lower in DP cells than in the other subsets . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Thrombin stimulated a rapid but transient accumulation of c Fos whereas the expression of Fra 1 , Fra 2 , c Jun and JunB was sustained throughout the G 1 phase of the cell cycle . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra 1 , Fra 2 , and c Fos bound to AP 1 but that prior treatment of the cells with TGFbeta reduced dramatically c Fos binding , suggesting that c Fos might be playing a negative regulatory role in clusterin gene expression . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
RESULTS : The normal corneal epithelium showed no staining with antibodies against c Fos , Fra 2 , FosB , c Jun or JunB , whereas the limbal and bulbar conjunctival epithelia were positive for c Fos , Fra 2 , and c Jun . ^^^ The dsyplastic epithelium showed positive labelling for c Fos , Fra 2 , c Jun , and JunD throughout its thickness . ^^^ The dysplastic epithelium treated with mitomycin C was not labeled by anti c Fos or Fra 2 antibody . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In this study , we have investigated for each factor and regulatory cascade of the intermediate step of immediate early gene induction , that is , c myc , c jun , jun D , jun B , c fos , fos B , fra 1 , fra 2 , and egr 1 ; fra 1 and fra 2 expressions were very low . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^ For c jun , junB , c fos and fra 2 , a relatively uniform expression pattern without significant differences among tumors was observed . junD protein amounts varied strongly in the tumor specimens . fosB expression levels also varied strongly in the tumors , weak / absent expression being found in 47 % , while 45 % exhibited strong / very strong levels of expression . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Using specific antibodies against AP 1 complex proteins , it was demonstrated by gel supershift assay that VT preferentially affected phosphorylated c Jun , Jun B , c Fos , and Fra 2 binding activities , whereas it did not alter Jun D and Fra 1 binding . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
RU 24969 alone produced elevations in locomotor activity and induced clear expression of c Fos , FosB and Fra 2 throughout the entire striatal complex . ^^^ The present study was undertaken to determine whether the effects of RU 24969 on immediate early gene expression extend to the additional Fos family transcription factors FosB and Fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The primary components present in this TGFbeta stimulated AP 1 complex are JunD and Fra 2 , although c Jun , and possibly Fos B , may also be present . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Recently , aldosterone was also shown to act on transcription factors in A 6 epithelia : It down regulates the mRNAs of the proliferation promoting c Myc , c Jun , and c Fos by a post transcriptional mechanism , whereas it up regulates that of Fra 2 ( c Fos antagonist ) at the transcriptional level . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In addition , AA also increased several AP 1 proteins , such as c Fos , Fra 1 , Fra 2 , JunB , JunD , and c Jun , or AP 1 and ENKCRE 2 DNA binding activity . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Finally , we show that TGF beta 1 increases c jun RNA levels and induces the formation of new complexes involving c jun , fra 2 , ATF 1 , and c fos , which react with Enhancer A and the DRE . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP 1 site by c Jun , JunB , JunD , c Fos , FosB , and Fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Extensive studies have established that light regulates c fos gene expression in the suprachiasmatic nucleus , the site of an endogenous circadian clock , but relatively little is known about the expression of genes structurally related to c fos , including fra 1 , fra 2 and fosB . ^^^ In the ventrolateral suprachiasmatic nucleus , c fos , fra 2 and fosB expression was stimulated after a subjective night ( but not subjective day ) light pulse . ^^^ Expression of the fra 2 gene was prolonged following photic stimulation , with elevated messenger RNA and protein levels that appeared unchanged for at least a few hours beyond the c fos peak . ^^^ Unlike c fos and fra 2 , the fosB gene appeared to be expressed constitutively in the ventrolateral suprachiasmatic nucleus throughout the circadian cycle ; immunohistochemical analysis suggested that delta FosB was the protein product accounting for this constitutive expression , while FosB was induced by the subjective night light pulse . ^^^ In the dorsomedial suprachiasmatic nucleus , c fos and fra 2 expression exhibited an endogenous circadian rhythm , with higher levels during the early subjective day , although the relative abundance was much lower than that measured after light pulses in the ventrolateral suprachiasmatic nucleus . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The increases of proENK and proDYN mRNA levels induced by KA were well correlated with the increases of c Fos , Fra 2 , FosB , c Jun , and JunB protein levels , which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The induction of c fos was transient , whereas marked elevation of long lasting Fos related antigens , including Fra 2 , was observed after repeated immobilization . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Supershift assays revealed that antibodies to c Fos , Fos B , Fra 2 , c Jun , Jun B , and Jun D shifted the binding of nuclear extracts from cells treated with PDGF BB to AP 1 sequences . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We also observed increased expression of mRNAs for Fos and Jun transcription factor family members c Fos , FosB , Fra 2 , and JunB , as well as Fos family proteins in the entorhinal cortex after MK 801 administration . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The members of the Fos protein family might be subdivided in two groups , according to their ability to transform rodent fibroblasts , transforming ( c Fos and FosB ) and non transforming ( Fra 1 and Fra 2 ) proteins . ^^^ As a result , Fra 1 and Fra 2 though efficiently form dimers with the Jun proteins , are weak transcriptional activators and inhibit the c Fos dependent activation in transient transfection assay . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
To identify which neuronal populations may be involved , we assessed Fos like immunoreactivity ( FLI ) using an antibody that recognizes the protein products of the fos family comprising Fos , Fos B , Fra 1 and Fra 2 , thus enabling detection of chronic neuronal activation . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We show here that ( 1 ) 5 Jun mediated repression of the endogenous SPARC gene is enhanced by Fra 2 but alleviated by ATF 2 , Fra 2 and ATF 2 being the two major partners of 5 Jun in the transformed cells ; ( 2 ) high basal activity as well as repression by 5 Jun and modulation by Fra 2 and ATF 2 is restricted to a small proximal fragment ( 124 / +16 ) of the chicken SPARC promoter ; ( 3 ) the activity of this minimal promoter is modulated by all the AP 1 family members known in chickens ( c Jun and JunD ; c Fos and Fra 2 ; ATF 2 ; c Maf , MafA , and MafB ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Of major significance was the finding that FosB could be detected as a component of AP 1 in 7 DIV cells only under excitotoxic conditions , whereas c Fos , Fra 2 , and JunD proteins were detectable under both excitotoxic and nontoxic conditions in cells of this age . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Immunohistochemical analysis revealed marked and predominant expression of Fos family members , including c Fos , Fos B and Fra 2 proteins , in the dentate granule layer of the hippocampus , but not in the pyramidal layers , 2 18h after administration . ^^^ Both Fos B and Fra 2 proteins were more potently expressed in nuclear and cytosolic fractions 18h after administration than 2h when determined on immunoblotting analysis . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Human PTH ( 1 34 ) and hPTH ( 1 84 ) increased steady state mRNA expression of c jun , junB , c fos , and fra 2 in an equivalent dose and time dependent manner . ^^^ Expression of c jun , junB , and c fos peaked 30 minutes after the injection while fra 2 expression peaked 30 minutes later . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
While c Fos , Fra 2 and JunB were increased in response to either stimuli , only Fra 1 , c Jun and JunD were increased by PMA . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Activation of transcription through the AP 1 site in Jurkat cells by JunD and / or Fra 2 was weak . c Jun , JunB , and c Fos activation was greater , although the level was still less than that with Tax . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Phase dependent light inducibility in the expression of fra 2 and c fos genes and in immunoreactive Fra 2 and c Fos protein expression was also evaluated , by in situ hybridization and immunocytochemistry . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Expression of egr 1 ( krox 24 ) , egr 2 ( krox 20 ) , egr 3 , c jun , junB , c fos , fosB , fra 1 , fra 2 , and CREB genes was analyzed by reverse transcription polymerase chain reaction ( RT PCR ) in Schwann cells isolated from neonatal rat sciatic nerves and in the cell lines MSC 80 ( mouse Schwann cells ) , NIH 3T3 ( mouse fibroblasts ) , and CHO ( Chinese hamster ovary cells ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^ RESULTS : Of the seven AP 1 factors , three ( c fos , fra 2 , and junB ) clearly showed higher expression levels in tumors when compared to matched normal endometrial samples . ^^^ These factors also correlated significantly with cell cycle promoters ( c fos with cyclin E , cyclin B 1 , cdk 2 , and cdk 4 ; fra 2 with cyclin B 1 ; and junB with cyclin D 1 ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Supershift assays using antibodies directed against different members of the Fos and Jun protein families showed that the AP 1 complex in retinal neurons includes proteins of the Fos family , namely , Fra 2 , c Jun , and Jun D . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We investigated by RT PCR whether PROG activated expression of transcription factors : Egr 1 ( Krox 24 ) Egr 2 ( Krox 20 ) , Egr 3 , c jun , jun B , jun D , c Fos , Fos B , Fra 1 , Fra 2 , CREB , ATF 4 , SCIP and Sox 10 in cultured Schwann cells . ^^^ Serum stimulated all genes activated by PROG in addition c fos , fra 1 and fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
With the aim to identify the oncoprotein partners implicated in the c Jun myogenic influence , we carried out stable transfection experiments of c Jun and / or ATF 2 , Fra 2 , c Fos overexpression in avian myoblasts . ^^^ In search for specific partners involved in this dual influence , we found that a reduction in the amounts of c Fos and Fra 2 and an increase in c Jun proteins occurred at cell confluence , a situation likely to favor cooperation between c Jun and ATF 2 during terminal differentiation . ^^^ Whereas c Fos and Fra 2 cooperated with c Jun to abrogate myoblast withdrawal from the cell cycle and terminal differentiation , ATF 2 co expression potentiated the positive myogenic c Jun influence . ^^^ In addition , myogenin expression was a positive target of this cooperation and this regulation occurred through a stimulation of myogenin promoter activity : ( 1 ) whereas c Fos or Fra 2 co expression abrogated c Jun stimulatory activity on this promoter , ATF 2 co expression potentiated this influence ; ( 2 ) using a dominant negative ATF 2 mutant , we established that c Jun transcriptional activity required functionality of endogenous ATF 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The DNA binding activities of c Fos , FosB / Delta FosB , Fra 1 , Fra 2 , and JunB were up regulated whereas JunD activity was decreased . c Fos , FosB / Delta FosB , and JunB were associated with Smad 4 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Ribonuclease protection assays demonstrated that increases in mRNA levels of the early response protooncogenes c jun , junB , fra 1 , and fra 2 accompanied cell proliferation at low concentrations of PM whereas apoptotic concentrations of PM caused transient increases in expression of fos and jun family members and dose responsive increases in mRNA levels of receptor interacting protein , Fas associated death domain , and caspase 8 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The systemic administration of both NMDA and KA induced marked expression of particular Fos family members , including c Fos and Fra 2 proteins , in hippocampal nuclear and cytosolic fractions . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We observed that withdrawal of IL 7 induced increased expression of jun and fos family member genes including c jun , junB , junD , c fos and fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Expression of c fos , fosB , fra 1 , fra 2 , and junB was low during early gestation , with a 5 to 10 fold increase on Day 23 during labor , and returned to low levels 1 day postpartum . ^^^ Administration of progesterone ( P 4 ; 16 mg / kg s . c . / day ) beginning on Day 20 ( to maintain elevated plasma P 4 levels ) prevented the onset of labor and blocked the expected rise in c fos , fosB , fra 1 , fra 2 , and junB expression on Day 23 . ^^^ In contrast , administration of the progesterone receptor antagonist RU 486 ( 10 mg / kg s . c . ) on Day 19 induced preterm labor and a premature increase in mRNA levels of c fos , fra 1 , fra 2 , and junB . ^^^ In unilaterally pregnant rats , stretch imposed by the growing fetus was found to increase the expression of c fos , fosB , fra 1 , fra 2 , and junB only in the gravid horn on the day of labor . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We have characterized the effects of chronic clozapine and haloperidol treatments on the expression of fos ( c fos , fosB , fra 2 ) and jun ( c jun , junB , junD ) family genes in the rat forebrain . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Here , we perform a direct comparison of the features of exogenous c Fos , Fra 1 and Fra 2 proteins expressed in murine tumor cells of epithelial origin , CSML 0 . ^^^ Although transactivation potential of c Fos is much stronger than that of Fra 1 and Fra 2 , all three proteins are capable of modulating transcription of target genes . ^^^ For instance , c Fos and Fra 1 but not Fra 2 activated genes of the urokinase system . ^^^ We therefore conclude that c Fos , Fra 1 and Fra 2 differently activate transcription of target genes and induce morphological changes in epithelioid carcinoma cells in a manner not directly linked to their transactivation potentials . . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We found that the zinc finger region of BCL 6 interacts with c Jun , JunB , and JunD proteins but does not bind c Fos or Fra 2 proteins . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Supershift EMSA revealed that VT preferentially induced JunB , JunD , phosphorylated c Jun , c Fos , and Fra 2 binding activities of the AP 1 family . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In order to identify regions of the CNS which are affected either differentially or in parallel by clozapine and haloperidol , we have used 2 deoxyglucose autoradiography to monitor local cerebral glucose utilisation ( LCGU ) , in parallel with in situ hybridisation to monitor the expression of five immediate early genes ( c fos , fos B , fra 1 , fra 2 and zif 268 ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Additionally , repeated administrations of nicotine transiently induced the c fos and c jun mRNA levels after the first third nicotine administration , and the c fos and c jun mRNA levels were returned to the basal level after the seventh administration of nicotine . c Fos , c Jun and Fra 2 protein levels were persistently increased until the seventh administration . ^^^ Immunohistochemical analysis showed that the increase of c Fos and c Jun proteins by repeated nicotine administrations is mostly medulla specific , while Fra 2 immuno reactivity was shown both in medulla and cortex . ^^^ These results suggest that proENK mRNA expression induced by repeated nicotine administrations may be mediated by AP 1 proteins , such as c Fos , c Jun and Fra 2 rather than CREB via interacting to the ENKCRE 2 DNA binding domain in rat adrenal medulla . . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Western blotting revealed that stress for 3 hr induced significant increases in expression of the components of AP 1 complex , c Fos , c Jun , and Jun B proteins , in adrenals , without markedly affecting expression of Fos B , Fra 2 , and Jun D proteins . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
We found that there is a lack of induction of c Fos , FosB , Fra 2 and JunB by acute cocaine exposure , and of DeltaFosB by repeated cocaine administration in both the NAc and CPu of D 1 receptor mutant mice compared with wild type control mice . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
This sustained transcriptional response correlated with a modest sustained increase in adrenal TH AP 1 binding , but not in the levels of Fra 2 or other fos or jun proteins . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The systemic administration of NMDA at 100 mg / kg resulted in marked expression of c Fos , Fra 2 and c Jun proteins in the granule cell layers of the dentate gyrus in murine hippocampus 2 h later , followed by a significant reduction of the incorporation of 5 bromo 2 ' deoxyuridine ( BrdU ) in a manner sensitive to the antagonist dizocilpine 2 days after administration . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^ Nuclear extracts from granulosa cells from 1 2 mm or 8 10 mm antral follicles bound an AP 1 DNA consensus sequence and complexes consisted predominantly of c Jun , JunD , JunB , c Fos , and Fra 2 . ^^^ In CL , c Jun , JunD , JunB , and Fra 2 were present in DNA binding complexes , and c Fos binding was not detected . ^^^ Differentiation to the luteal phenotype involves a reduction in nuclear c Jun and c Fos and a predominance of JunD and Fra 2 . . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Among the early response genes analyzed , c myc , junB , junD , c jun , c fos , fosB , fra , as well as max , mad 1 4 , sin 3 , only c jun and fra 2 mRNAs were up regulated after 1 , 25 ( OH ) ( 2 ) D ( 3 ) exposure . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The JNK deficient cells exhibited decreased expression of c Jun , JunD , c Fos , Fra 1 , and Fra 2 ; decreased phosphorylation of c Jun and JunD ; and decreased AP 1 DNA binding activity . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The complexes formed with labeled AP1 / E box oligonucleotide were reduced or supershifted with antisera to Fos family , c Fos , Fra 2 , and Jun D . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Treatment of pregnant rats with PTHrP did not affect the time of delivery , concentrations of progesterone in maternal plasma , or levels of c fos , fra 2 , or parathyroid hormone / PTHrP receptor mRNA on any gestational day . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Of the AP 1 proteins studied , c Jun was expressed at the highest level , followed by JunD , c Fos , and Fra 2 , although different treatments induced slightly different levels of expression . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
RESULTS : Compared with RPE65Met ( 450 ) , introduction of the RPE65Leu ( 450 ) variant led to increased levels of RPE 65 protein , accelerated rhodopsin regeneration , loss of protection against light induced damage , and AP 1 responsiveness to toxic light doses , despite the absence of c Fos . c Fos was mainly replaced by Fra 2 . ^^^ Under conditions of high rhodopsin availability during exposure to light , Fra 2 and , to a minor degree , FosB substitute for c Fos and enable light induced AP 1 activity and thus photoreceptor apoptosis . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Here , the major cis regulatory elements that control IFN gamma inducible NOS 2 gene transcription in human lung epithelial cells are identified as composite response elements that bind signal transducer and activator of transcription 1 ( STAT 1 ) and activator protein 1 ( AP 1 ) , which is comprised of c Fos , Fra 2 , c Jun , and JunD . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In a Gal 4 fusion assay , Pdcd 4 specifically inhibited activation of c Jun and c Fos activation domains , but did not inhibit activation of JunB , JunD , Fra 1 , or Fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Role of the Fos family members , c Fos , Fra 1 and Fra 2 , in the regulation of cell motility . ^^^ Two cell lines with different expression profiles of AP 1 were employed focusing on the Fos family members c Fos , Fra 1 and Fra 2 . ^^^ Transactivation motifs are found in c Fos , but not in Fra 1 or Fra 2 . ^^^ The adenocarcinoma CSML 0 cells display a low motility and do not express Fra 1 or Fra 2 , and only very little c Fos . ^^^ In contrast , the fibroblastoid L 929 cells express both Fra 1 and Fra 2 , but no c Fos , and these cells display a high motility . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In the current study , we examined the expression of seven fos / jun family member mRNAs ( c fos , fosB , fos related antigen ( fra ) 1 , fra 2 , junB , c jun , and junD ) and three other IEG mRNAs ( egr 1 , egr 3 , and nur 77 ) in mouse brain following short term ( 6 h ) sleep deprivation ( SD ) and 4 h recovery sleep ( RS ) after SD . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
AP 1 subunits c Fos , Fos B , Jun B , and Jun D , but not Fra 1 or Fra 2 , were all induced by CpG ODNs in B cells within 30 minutes of stimulation , followed by c Jun at 1 2 hours . c Jun reached maximum at 6 hours . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Moreover , ERK activation mediates acute cocaine induced expression of Fos family genes , including c fos , fosB and fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
The role of the AP 1 transcription factors c Fos , FosB , Fra 1 and Fra 2 in the invasion process of mammary carcinomas . ^^^ Members of the Fos family of AP 1 transcription factors ( c Fos , FosB , FosB 2 , Fra 1 and Fra 2 ) are able to form dimers with Jun proteins which bind to the regulatory sequences of target genes . ^^^ Therefore , we performed transient transfections with expression vectors for c Fos , FosB , FosB 2 , Fra 1 and Fra 2 , followed by matrigel invasion assays . ^^^ In a less degree , the invasive potential of MDA MB 231 cells was stimulated by Fra 2 , whereas MCF 7 invasion was enhanced by c Fos and FosB . ^^^ By double labelling immunocytochemistry , PAI 1 up regulation was observed in cells transfected with c Fos , Fra 1 and Fra 2 expression vectors , whereas MMP 1 and MMP 9 expression was not affected . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Exposure to CS caused a marked upregulation of c Jun , c Fos , and Fra 1 , but not of Fra 2 , Jun B , and Jun D expression . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Supershift EMSA identified c Jun , Fra 2 , and c Fos in AP 1 binding complexes in IE 1 transfected NIH 3T3 cells . ^^^ Ectopic expression of c Jun plus Fra 2 , but not c Fos , induced relB promoter activity . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Dimers comprising Fos / Jun proteins conferred greater transcriptional activity than Jun dimmers , with Fra 2 / JunB combination conferring greatest activity . ^^^ Because expression of Fra 2 increases earlier than other Fos family members and confers the highest transcriptional drive to the Cx 43 promoter , our data suggest that Fra 2 is a central component in the regulation of Cx 43 expression during labor . . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Deoxynivalenol was found to readily induce expression of cytokines ( IL 1alpha , IL 1beta , and IL 6 and IL 11 ) , chemokines ( MCP 1 , MCP 3 , CINC 1 and MIP 2 ) , components of the activator protein 1 ( AP 1 ) transcription factor complex ( c Fos , Fra 2 , c Jun and JunB ) , as well as two hydrolases ( MKP 1 , CnAbeta ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Several genes were selected from p 53 related genes ( CDKN1A , TP53I11 and CDC 14 ) , Akt 2 related genes ( PRKCD , BRCA 1 , TRIB 3 and APPL ) , mitogen activated protein kinase related genes ( RSK and SH3BP5 ) , Ras superfamily genes ( RAP1GA1 , RHOC and ARHGDIA ) and AP 1 family and related genes ( RIP 140 , FOS , ATF 3 , JUN and FRA 2 ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Finally , the application of EGF to young cells resulted in increased phosphorylation of Fra 2 , a Fos protein component of the Jun / Fos heterodimer AP 1 complex . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Gene knockout experiments have demonstrated that , among the Fos family , only c Fos is indispensable for osteoclast differentiation but that c Fos can be substituted for by other Fos family members including FosB / DeltaFosB , Fra 1 and Fra 2 , in most other tissues and cells . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Repeated IMO triggered increased phosphorylation and levels of CREB along with transient induction of c Fos and increased Fra 2 expression . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Immunodepletion gel shift assays demonstrated that GP 5 EpRE bound JunB , c Jun , FosB , and Fra 2 from unstimulated cells , and that after exposure to HNE , EpRE binding complexes contained nuclear factor erythroid 2 related factor ( Nrf ) 1 , Nrf 2 , JunB , c Jun , FosB , c Fos , Fra 1 , and Fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Members of the Fos family ( c Fos , FosB and its smaller splice variants , Fra 1 and Fra 2 ) dimerise with Jun proteins to form the AP 1 transcription factor complex . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Ischemia induced the expression and binding of c Fos , c Jun , JunB , FosB , and Fra 2 to a noncanonical activating protein 1 ( AP 1 ) site present in the MMP 2 promoter and decreased binding of the transcriptional repressor JunD . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
PTH enhanced mRNA expression of c fos , junB , and fra 2 in the distal femur metaphyses of both genotypes ; expression of these transcripts was consistently lower in PTH treated Nf 1 ( + / ) mice . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Following the addition of 1 nmol / L of 1 , 25D , the cellular content of each of these four proteins markedly increased in a sustained manner , whereas the increases in c fos , fra 1 , fra 2 , and jun D were minimal , if any . ^^^ In HL 60 cells in an early stage of differentiation , the principal AP 1 components detected by gel shift analysis include c jun , ATF 2 , fos B , fra 1 , and fra 2 . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
Further , in contrast to the JunD and Fra 2 components present in the AP 1 complex at this AP 1 site in UECs , c Fos was the major detectable AP 1 component in HCCCs . ^^^
Interacting proteins: P15408 and P01100	Pubmed	SVM Score :0.0
For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^