Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.53884945
We demonstrate that CREB will form heterodimers with ATF 1 , but not ATF 2 , Jun , Fos , or C / EBP whereas , ATF 2 will form heterodimers with Jun and Fos , but not with C / EBP or ATF 1 . 0.53884945^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Supershift assays revealed binding of Jun and Fos to AP 1 and CRE sequences and binding of activating transcription factor 2 to CRE . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
The presence of several transcription factor proteins , including JunB , JunD , c Fos , Fra 1 , CREB 1 , activating transcription factor 2 , NF KB p 50 , p 52 , and p 65 , and CAAT / enhancer binding protein delta , was demonstrated by supershift analysis . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
GA treatment led to a decrease in the nuclear content of c Jun but not that of c Fos or of activating transcription factor 2 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Inhibition of protein kinase A or the transcription factor cAMP response element binding protein blocks the stimulation of both promoters by mutant receptors , whereas inhibition of activating transcription factor 2 , c Fos , or c Jun has only minor effects . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Incubation of VSMC with ouabain resulted in rapid induction of c Fos protein expression with an approximately sixfold elevation after 2 h of incubation . c Jun expression was increased by approximately fourfold after 12 h , whereas expression of activating transcription factor 2 , cAMP / Ca ( 2+ ) response element binding protein ( CREB ) 1 and c Myc was not altered . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
These actions were dependent upon the activation of multiple MAPK signal pathways , including ERK 5 kinase ; transactivation of the epidermal growth factor receptor ; and the increased expression and activities of transcription factors ELK 1 , activating transcription factor 2 , c Fos , c Jun , activator protein 1 , and myocyte enhancer factor 2 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
They include all members of the jun and fos families as well as the cAMP response element binding protein , activating transcription factor 1 , activating transcription factor 2 , and RelA ( p 65 ) . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Activating transcription factor 2 ( ATF 2 ) is a member of the activator protein 1 family of transcription factors , which includes c Jun and c Fos . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Single IMO elicited rapid induction of c Fos and phosphorylation of cyclic AMP response element binding protein ( CREB ) without changing the expression of early growth response ( Egr ) 1 , Fos related antigen ( Fra ) 2 or phosphorylated activating transcription factor 2 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
This protein , HB 16 , displays structural similarity to CREB and to c Jun and c Fos , which bind the related 12 O tetradecanoylphorbol 13 acetate response element ( TRE ) . ^^^ In addition , HB 16 could form a complex with c Jun but not with c Fos . ^^^ Despite its structural similarity to c Jun and c Fos and its interaction with c Jun , HB 16 had approximately a 10 fold lower affinity for the TRE sequence than for the CRE sequence . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Heterodimerization of c Jun with ATF 2 and c Fos is required for positive and negative regulation of the human urokinase enhancer . ^^^ Our data further suggest that c Fos can act as a repressor of the c Jun / ATF 2 binding site , revealing an important functional difference , with respect to canonical AP 1 elements . . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
ATF 2 also bent DNA toward the minor groove in heterodimers formed with Fos , Fra 2 , and Jun . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
In vitro binding studies revealed that , in contrast to the consensus AP 1 site which is preferentially targeted by dimers composed of the Jun and Fos families , the jun2TRE binds heterodimers composed of cJun and ATF 2 ( like ) proteins . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Consistent with these data , CD 40 signals up regulate c jun but not c fos mRNA and alter the transcription factor ATF 2 but not the Raf 1 protein . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Anisomycin and UV radiation have been suggested to induce c fos and c jun transcription via JNK / SAPK mediated phosphorylation of TCF ( ternary complex factor ) , for c fos induction [ 6 8 ] , and c Jun and / or ATF 2 for c jun induction [ 9 11 ] [ 12 , 13 ] . ^^^ By using the p38 / RK inhibitor SB 203580 [ 20 , 21 ] , we show that activation of p38 / RK and / or its downstream effectors are essential for anisomycin and UV stimulated c fos / c jun induction and histone H3 / HMG 14 phosphorylation , whereas JNK / SAPK activation and phosphorylation of c Jun and ATF 2 are insufficient for these responses . . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Analysis of the induced binding complexes indicates that c fos , c jun , and ATF 2 were present , but also two additional jun family members , JunB and JunD . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Proteins of the c Jun , ATF 2 , and c Fos families aggregate to form DNA binding homodimers or heterodimers called activating protein 1 ( AP 1 ) . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Antibodies to c Fos or ATF 2 inhibit formation of the complex formed by proteins from cells treated with chlorophenylthio cyclic AMP and T 3 but not by those from cells treated with T 3 alone . ^^^ These results suggest an important role for c Fos and ATF 2 in glucagon mediated inhibition of transcription of the malic enzyme gene . . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
The distribution of SRF and ATF 2 suggests that their putative target genes c fos , junB , krox 24 and c jun can be independently regulated from SRF and ATF 2 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
In addition , ATF 2 binds to the 2 . 4 kb element even without induction and c Fos to the 6 . 9 kb element only after induction . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Other D N inhibitors generated in a similar manner with the dimerization domains of Fos , Jun , C / EBP , ATF 2 , or VBP did not block CREB DNA binding activity , nor did they inhibit transcriptional activation of a minimal promoter containing a single CRE in PC 12 cells . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
The expression of the pre existing transcription factors SRF , CREB and ATF 2 which contribute to the transcriptional control of jun , fos and krox genes , was not affected by Ang 2 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
The expression of c Jun , JunB , JunD , c Fos and ATF 2 transcription factors was studied in L4 / L5 dorsal root ganglion neurons of adult rats , in order to determine the extent to know to which extend the expression of transcription factors in vitro parallels the pathophysiological expression in vivo . ^^^ Expression of Jun , Fos , and ATF 2 proteins in axotomized explanted and cultured adult rat dorsal root ganglia . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Enhanced Jun activity is likely to target several different genetic programs as Jun forms heterodimers with one of several members of the Fos and ATF 2 subfamilies , resulting in transcription factors with different sequence specificities . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
We demonstrated increased binding activity to the AP 1 and CREB / ATF 2 consensus binding sites and show that the AP 1 complex is composed of c Jun , JunD , c Fos , and ATF 2 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Transcription factors of the AP 1 / ATF family , including c Fos , c Jun , and ATF 2 , play an important role in the regulation of cell proliferation and differentiation , and changes in their levels and / or activities may contribute to oncogenesis . ^^^ In the absence of c fos gene expression , c Fos protein appears to be replaced by proteins of Fos family ( Fra 1 ) and ATF family ( ATF 2 and ATFa ) . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
The ATF 2 related transcription factor CRE binding protein contributes to the activity of the cyclin A CRE in chondrocytes , whereas c Jun and c Fos regulate the promoter independently of the CRE . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
We could also detect an association of ATF 2 and c Fos with one of the complexes . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Like all other bZIP proteins , MEQ is capable of dimerizing with itself and with a variety of bZIP partners including c Jun , B Jun , c Fos , CREB , ATF 1 , ATF 2 , and SNF . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
We show here that ( 1 ) 5 Jun mediated repression of the endogenous SPARC gene is enhanced by Fra 2 but alleviated by ATF 2 , Fra 2 and ATF 2 being the two major partners of 5 Jun in the transformed cells ; ( 2 ) high basal activity as well as repression by 5 Jun and modulation by Fra 2 and ATF 2 is restricted to a small proximal fragment ( 124 / +16 ) of the chicken SPARC promoter ; ( 3 ) the activity of this minimal promoter is modulated by all the AP 1 family members known in chickens ( c Jun and JunD ; c Fos and Fra 2 ; ATF 2 ; c Maf , MafA , and MafB ) . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
JDP 2 binds DNA as a homodimer and heterodimer with ATF 2 and Jun proteins but not with c Fos proteins . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
In order to determine the identities of individual B ZIP proteins in various AP 1 complexes we tested the effect of dominant negative mutants to the B ZIP proteins c Fos , ATF 2 , ATF 4 and CCAAT enhancer binding protein ( C / EBP ) on the activities of the collagenase and c Jun promoters . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
We have profiled multiple transcription factors involved in inflammation including NFkappaB p 50 , NFkappaB p 65 , c Rel , c Fos , CREB 1 , and ATF 2 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
CREB 2 and ATF 2 in nuclear extracts of unstimulated endothelial cells bound to CRE , whereas USF 2 and c Jun or c Fos bound to non CRE sites . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
These studies reveal the presence of Tax , a variety of ATF / CREB and AP 1 family members ( CREB , CREB 2 , ATF 1 , ATF 2 , c Fos , and c Jun ) , and both p 300 and CREB binding protein at the HTLV 1 promoter . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Supershift assays demonstrated that c Jun , c Fos and ATF 2 are part of the AP 1 complex , indicating that activated c Jun is dimerized with c Fos or ATF 2 for control of its target gene expression . ^^^ Our results suggest strongly that human amylin induces apoptosis through stimulation of expression and activation of c Jun , and that co expression and dimerization of c Jun and c fos or ATF 2 may be important for activation of the downstream apoptotic process . . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Phosphorylated c Jun , JunB , JunD , and Fra 1 , but not c Fos , FosB , or ATF 2 , are detected in the AP 1 DNA binding complex in cells exposed to trivalent arsenicals . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Jun dimerization with Fos versus ATF 2 caused it to bind opposite half sites at nonconsensus AP 1 elements . ^^^ Similarly , ATF 2 bound to opposite half sites in Fos ATF 2 NFAT1 and ATF 2 Jun NFAT 1 complexes . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
With the aim to identify the oncoprotein partners implicated in the c Jun myogenic influence , we carried out stable transfection experiments of c Jun and / or ATF 2 , Fra 2 , c Fos overexpression in avian myoblasts . ^^^ In search for specific partners involved in this dual influence , we found that a reduction in the amounts of c Fos and Fra 2 and an increase in c Jun proteins occurred at cell confluence , a situation likely to favor cooperation between c Jun and ATF 2 during terminal differentiation . ^^^ Whereas c Fos and Fra 2 cooperated with c Jun to abrogate myoblast withdrawal from the cell cycle and terminal differentiation , ATF 2 co expression potentiated the positive myogenic c Jun influence . ^^^ In addition , myogenin expression was a positive target of this cooperation and this regulation occurred through a stimulation of myogenin promoter activity : ( 1 ) whereas c Fos or Fra 2 co expression abrogated c Jun stimulatory activity on this promoter , ATF 2 co expression potentiated this influence ; ( 2 ) using a dominant negative ATF 2 mutant , we established that c Jun transcriptional activity required functionality of endogenous ATF 2 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
This was accompanied by an activation of c Jun and ATF 2 , but not Elk 1 and c Fos . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
The inductive effects of HER 2 / neu were mediated , in part , by enhanced binding of AP 1 ( c Jun , c Fos , and ATF 2 ) to the cyclic AMP response element ( 59 / 53 ) of the COX 2 promoter . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Piperine is a potent inhibitor of nuclear factor kappaB ( NF kappaB ) , c Fos , CREB , ATF 2 and proinflammatory cytokine gene expression in B16F 10 melanoma cells . ^^^ Immune regulation , induction of various inflammatory and growth regulatory genes such as IL 1beta , IL 6 , TNF alpha and GM CSF require activation of transcription factors such as nuclear factor kappaB ( NF kappaB ) , activated transcription factor ( ATF 2 ) , c Fos and cAMP response element binding protein ( CREB ) . ^^^ We found that the nuclear translocation of p 65 , p 50 , c Rel subunits of NF kappaB and other transcription factors such as ATF 2 , c Fos and CREB were inhibited by the treatment of piperine . . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Increased activity of activator protein 1 transcription factor components ATF 2 , c Jun , and c Fos in human and mouse autosomal dominant polycystic kidney disease . ^^^ Here , it is reported that activity of the AP 1 components c Jun , ATF 2 , and c Fos is altered in renal cystic tissue of patients with autosomal dominant polycystic kidney disease and of hypomorphic Pkd 1 mice with polycystic kidney disease . ^^^ Significant upregulation of Thr 71 and Thr69 / 71 phosphorylated ATF 2 and Ser 73 phosphorylated c Jun and increased c Fos were detected in small cysts and ( dilated ) ducts and tubules surrounded by fibrotic interstitium . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Reciprocal effects of varicella zoster virus ( VZV ) and AP 1 : activation of jun , fos and ATF 2 after VZV infection and their importance for the regulation of viral genes . ^^^ Performing quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) we found an increase of transcription of AP 1 components jun , fos and of ATF 2 at different times post infection ( p . i . ) . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Together with bZIP proteins of the Fos and Jun families , ATF 2 constitutes the AP 1 transcription factor complex . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Viability was analyzed by a colorimetric assay , islet mass by DNA content , JNK activity by Western blots , AP 1 nuclear activity with a promoter Luciferase AP 1 responsive construct , and c Fos , Jun D , and ATF 2 nuclear activities by an enzyme linked immunosorbent assay . ^^^ The 17beta estradiol induced a significant reduction in nuclear AP 1 , c fos , Jun D , and ATF 2 activities . ^^^ These effects were associated with reduction in JNK targets , including the nuclear activities of transcription factors AP 1 , c Jun , c Fos , Jun D and ATF 2 , involved in apoptosis in beta cells . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
We found that the amount of transcription factors binding to promoter sequences of c Fos , ATF 2 , CREB 1 , and FosB was increased by the expression of SARS CoV N . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Most gene expression alterations were detected 24 h after paclitaxel administration and affected genes involved in various biological functions including cell cycle regulation and cell proliferation ( CDC 2 , CDKN1A , PLAB , and TOP2A ) , apoptosis ( BNIP 3 and PIG 8 ) , signal transduction and transcriptional regulation ( ARF 1 , ATF 2 , FOS , GNA 11 , HDAC 3 , MADH 2 , SLUG , and SPRY 4 ) , fatty acid biosynthesis and sterol metabolism ( FDPS , IDI 1 , LIPA , and SC5D ) , and IFN mediated signaling ( G1P3 , IFI 16 , IFI 27 , IFITM 1 , and ISG 15 ) . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
The protein sequence deduced from the open reading frame of a human placental cDNA encoding a cAMP responsive enhancer ( CRE ) binding protein ( CREB 327 ) has structural features characteristic of several other transcriptional transactivator proteins including jun , fos , C / EBP , myc , and CRE BP 1 . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
All three proteins , TREB 5 , TREB 7 and TREB 36 , contained a leucine zipper structure and basic amino acid domain , which are conserved in FOS , JUN and CREB , and also had multiple potential phosphorylation sites . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Several MAPK regulated host transcription factors such as c Jun , STAT1alpha , MEF 2 , c Myc , ATF 2 and c Fos were induced early during infection , and ERK inhibition significantly blocked the c Fos , c Jun , c Myc , and STAT1alpha activation in the infected cells . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Differential bindings of the CREB 1 , ATF 2 , c jun to the CRE site , and the c fos , c jun , ATF 2 to the AP 1 site are demonstrated by DNA affinity protein binding , supershift , and chromatin immunoprecipitation assays . ^^^ These results indicate that H . pylori acts through TLR 2 and TLR 9 to activate MAPKs , especially p 38 , and their downstream transcription factors ( CREB 1 , ATF 2 , c jun , and c fos ) , resulting in the activations of CRE and AP 1 on the COX 2 promoter . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Furthermore , almost all kinds of the AP 1 family genes including c jun , c fos , junD , junB , atf 2 and b atf were successfully selected from an mRNA display library constructed from a mouse brain poly A ( + ) RNA after six rounds of selection . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Expression of transcription factors c Fos , c Jun , CREB 1 and ATF 2 , and caspase 3 in relation with abnormal tau deposits in Pick ' s disease . ^^^ In order to better understand the possible role of selected transcription factors and members of the caspase family in cell death and cell survival , immunohistochemistry to c Fos , c Jun , CREB 1 , ATF 2 ; c Fos ( P ) , c Jun ( P ) and CREB 1 ( P ) ; and procaspase 8 , procaspase 3 and active ( cleaved ) caspase 3 immunohistochemistry was carried out in the frontal cortex and hippocampus . ^^^ Increased expression of c Fos , c Jun , CREB 1 and ATF 2 was observed in PiD cases . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
In HL 60 cells in an early stage of differentiation , the principal AP 1 components detected by gel shift analysis include c jun , ATF 2 , fos B , fra 1 , and fra 2 . ^^^ In cells with a more established monocytic phenotype , the demonstrable AP 1 components are c jun , ATF 2 , jun B , and fos B . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
Authentic CRE BP 1 , c Jun and c Fos proteins produced by in vitro translation also bound to the E1A column . ^^^ However , efficient binding of in vitro translated CRE BP 1 and c Fos proteins to E1A required preincubation with NE . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
CRE BP 1 also forms heterodimers with Jun but not with Fos . ^^^
Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P15336 and P01100	Pubmed	SVM Score :0.0
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