Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.74350591
The proto oncoprotein c Jun forms as a heterodimer with c Fos , the transcription factor AP 1 . 0.74350591^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.90435389
These interactions complement interactions between c Jun and c Fos , and between Smad 3 and Smad 4 . 0.90435389^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.57410461
The C terminal homology region of Jun was sufficient for DNA binding , dimer formation , and interaction with Fos . 0.57410461^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.65394583
Direct interaction between fos and jun nuclear oncoproteins : role of the ' leucine zipper ' domain . 0.65394583^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.60168588
Ternary complex formation between mutated Fos , Jun and DNA was determined in vitro in the presence of denaturant . 0.60168588^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.59417269
The bending cooperativity was directed toward the interaction interface between Fos Jun and NFAT 1 . 0.59417269^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.56308662
We show that either AP 1 site can interact efficiently in vitro with any of the three different Jun products as heterodimers with c Fos . 0.56308662^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.68176939
Gonadotropin regulation of c fos and c jun messenger ribonucleic acids in cultured rat granulosa cells . c Fos and c jun are immediate early proto oncogenes encoding proteins for the heterodimer AP 1 , a DNA binding complex which regulates gene transcription . 0.68176939^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :1.196642
In transient expression and in vitro degradation experiments , the stability of c Fos was decreased when the protein was dimerized with phosphorylated c Jun . c Jun protein isolated from phorbol ester induced cells did not target c Fos for degradation , which suggests that c Fos is transiently stabilized after stimulation of cell growth . 5 Fos protein , the retroviral counterpart of c Fos , was not susceptible to degradation targeted by c Jun . . 1.196642^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.70852177
Despite its structural similarity to c Jun and c Fos and its interaction with c Jun , HB 16 had approximately a 10 fold lower affinity for the TRE sequence than for the CRE sequence . 0.70852177^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :1.0033407
To look for interactions between AP 1 and GATA 2 , transactivation experiments were performed with expression vectors encoding c Jun , c Fos , and GATA 2 . 1.0033407^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.6904367
This group of factors regulates the expression of CAp responsive genes : one of them , the c fos proto oncogene , produces a nuclear protein that binds with other proteins encoded by c jun proto oncogene , to form a transcription factor , AP 1 . 0.6904367^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.62797922
The proto oncoprotein c Jun , when complexed with c Fos , forms the climeric complex identified as AP 1 which regulates transcription directly by binding to AP 1 responsive genes . 0.62797922^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.77139553
Gel shift analyses revealed that c Jun , JunD , and c Fos bound to the TRE 2 region and that the p2672CAT activity level was elevated by co transfection with c Jun and c Fos or with JunD and c Fos expression vectors . 0.77139553^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.78366321
These signaling pathways converge in the nucleus of cells to induce c Jun , which heterodimerizes with constitutively expressed c Fos to form activated complexes of the transcription factor AP 1 . 0.78366321^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :1.0335795
C Jun is phosphorylated by c Jun N terminal kinase ( JNK ) and associates with c Fos to form the AP 1 transcriptional activation complex that can drive cytokine expression . 1.0335795^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.56262642
In DU 145 cells both c Fos and c Jun were expressed and treatment with TNF activated c Jun NH 2 terminal kinase ( JNK ) , needed for AP 1 activation . 0.56262642^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.83403005
From transient transfection analysis , c Jun was found to strongly activate a CYP2J2 luciferase reporter construct , but co transfection with plasmids encoding c Fos or c Fos related antigens , Fra 1 and 2 , abrogated reporter activity . 0.83403005^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.50697114
We show that c Fos interacts with STAT 1 after IFN gamma activation and the c Fos / STAT 1 complex binds to the gamma activated site ( GAS ) element in close proximity to AP 1 sites located at 4 . 9 kb upstream of the transcription start site . 0.50697114^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.57044932
However , the mutation of AP 1 binding sites in the promoter region did not abrogate the regulatory effect of c fos and the effect of c fos was diminished by co transfection with c jun , but not with fosB , suggesting no relation between the regulatory effect and a c Fos / AP 1 complex . 0.57044932^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :1.1370023
C Jun , when phosphorylated by c Jun N terminal kinase ( JNK 1 ) associates with c Fos to form the AP 1 transcription factor that activates gene expression . 1.1370023^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.93519776
To better understand the molecular mechanisms involved in this down regulation of c Jun activity , a large number of HBZ / c Fos chimeras was constructed and analyzed for their ability to interact with c Jun , to bind to the AP 1 motif and to stimulate expression of a reporter gene containing the collagenase promoter . 0.93519776^^^ Like c Fos , HBZ ( HTLV 1 bZIP factor ) is able to interact with c Jun but differs considerably from c Fos in its ability to activate AP 1 responsive genes since HBZ rather inhibits transcriptional activity of c Jun . 0.66224645^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.86649917
This suggests that FOS , which is known to form a AP 1 heterodimer transcription complex with the proto oncogen product , Jun , may bind to the tentative AP 1 binding site , found within the human CCK promoter and thereby modulates basal and enhanced CCK mRNA expression in SK N MC cells . . 0.86649917^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.65715135
We have shown that while c Fos is the major Fos protein associated with the Jun proteins ( c Jun , JunB , and JunD ) soon after serum stimulation , at later times Fra 1 and Fra 2 are the predominant Fos proteins associated with the different Jun proteins . 0.65715135^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.51662399
Association of Fos and Jun with the AP 1 site results in a conformational change in the basic amino acid regions that constitute the DNA binding domain . 0.51662399^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.79647403
The leucine zipper of the oncoprotein Jun is particular in that Jun may form homodimers as well as heterodimers with the oncoprotein Fos , which are however more stable than the Jun Jun homodimers . 0.79647403^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.52624328
Like c Fos and Fra 1 , Fra 2 formed stable heterodimers with c Jun , JunB or JunD in vitro and all these complexes had specific DNA binding activity to AP 1 binding sites ( AP 1 sites ) or related sequences . 0.52624328^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.64156291
The fos protein encoded by this construct ( termed Baf ) was enriched by biochemical purification techniques and was found to form a specific complex with c jun obtained by in vitro transcription / translation . 0.64156291^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.63416535
Using proteins synthesized in reticulocyte lysates , we have shown that Fra 1 , like Fos , binds to the AP 1 recognition element cooperatively with Jun . 0.63416535^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.6101904
Heterodimerization of these c Fos variants with c Jun reveals a complex behavior , in that the DNA binding affinity of these heterodimers does not simply increase with the number of isoleucine side chains in position a . 0.6101904^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.58866846
However , Fos interacts significantly more efficiently than p 21 ( SNFT ) with Jun and NF AT , and the replacement of Fos by p 21 ( SNFT ) in the trimolecular complex drastically alters protein DNA contacts . 0.58866846^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.85762017
Although the human PR gene does not contain an estrogen response element ( ERE ) , we have identified a putative activating protein 1 ( AP 1 ) site at +90 in the PR gene that was hypersensitive to deoxyribonuclease 1 cleavage in genomic Southern analysis , bound purified Fos and Jun , formed a complex with Fos / Jun heterodimers present in MCF 7 nuclear extracts in gel mobility shift assays , and functioned as an estrogen responsive enhancer in transient cotransfection assays . 0.85762017^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TPA treatment caused the increased expression of c fos containing AP 1 specific binding activity in selected tumor cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protooncogenes investigated in this study were c fos , c jun , c myc , N myc , HER 2 / neu , c erbB , c fms , and c Ha ras . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These four additives induced transient increases in c fos , c jun and c myc proto oncogene mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of GLUT 1 mRNA was preceded by rapid and transient expression of c fos and c jun protooncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We showed that an early accumulation of c fos , c jun and c myc mRNA occurred in both phenomena but with different kinetics . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the hsp 70 gene is preceded by activation of the cellular protooncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PModS was found to dramatically increase mRNA levels for c fos , but had no effect on c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protooncogenes c fos and c jun were expressed after half an hour of incubation with PMA . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mos expression also increased c fos and c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stretch caused an induction of immediate early genes such as c fos , c jun , c myc , JE , and Egr 1 , but not Hsp 70 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , the expression of c fos and c jun mRNA transiently increased both in the cerebral cortex and in the hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TPA induced c fos and junB mRNAs transiently and preceding NGF mRNA induction but c jun mRNA remained undetectable . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both FGF and PMA are good inducers of the accumulation of c fos and c jun mRNAs , whereas insulin has little effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phorbol ester induced c fos , jun B , and jun D RNAs within 20 min in both cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Within 1 h of refeeding , jejunal and ileal c fos , jun B and zif / 268 mRNA and colonic zif / 268 dramatically increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In parallel , the regulation of cellular c fos as well as c jun and c myc genes expression has been studied . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A1 was accompanied by augmented transcription of c jun and c fos in response to TPA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ca ( 2+ ) dsRNA produces a stimulating effect on c fos and c jun gene transcription in fibroblasts and HeLa S 3 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Functional interaction between estrogen receptor and proto oncogene products c Jun and c Fos ] . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Authentic CRE BP 1 , c Jun and c Fos proteins produced by in vitro translation also bound to the E1A column . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 site and the cAMP and serum response elements of the c fos gene are constitutively occupied in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , platelet activating factor was capable of inducing transcription of the nuclear proto oncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proximal element does not bind c Ets 1 , but may be activated indirectly by increased synthesis of c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Co induction of jun B and c fos in a subset of neurons in the spinal cord . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These studies are among the first to suggest a functional dissociation of c Jun from c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two of these genes , c jun and c fos , play an important role in the control of cellular differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Products of two cellular immediate early genes , c fos and c jun , are components of the transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of jun B expression by TPA in these cells preceded that of the c jun and c fos genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In fibroblasts , insulin is a weak mitogen and does not induce expression of c fos , c jun or p 33 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of antisense c jun or antisense c fos expression vectors prevents TGF beta 1 autoinduction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional activation of a conserved sequence element by ras requires a nuclear factor distinct from c fos or c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , transfer of 180 c Fos C terminal amino acids to Jun conferred upon it the ability to repress . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes c fos and c jun function cooperatively as inducible transcription factors in signal transduction processes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The products of c fos and c jun ( Fos and Jun ) function in gene regulation by interacting with the AP 1 binding site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
[ c fos gene , c jun gene ] . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c fos gene product is associated in transcriptional complexes with the c jun product . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This was also true of the expression of c jun , c fos and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 1 enhanced expression of c jun messenger RNA , whereas the antigenic signal enhanced messenger RNA expression of c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cell surface stimulation results in an increase in c fos and c jun products . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c Fos protein interacts with c Jun / AP 1 to stimulate transcription of AP 1 responsive genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 11 induces tyrosine phosphorylation , and c jun and c fos mRNA expression in human K 562 and U 937 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , HHIF induced the expression of immediate early genes c fos and c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , administration of NMA does not induce c Fos or c Jun expression in GnRH neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Promoter activity regulated by activator protein 1 or c fos serum response element consensus sequences was also increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Insulin stimulates phosphorylation of c Jun , c Fos , and Fos related proteins in cultured adipocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JunB and JunD were poorer inhibitors . c Fos expression did not potentiate the negative effect of Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c myc is increased in psoriatic plagues whereas that of c fos and c jun is decreased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 binding proteins contained c Jun , Jun D , and Fra 1 , but marginal amounts of Jun B and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential induction and regulation of c jun , junB , junD and c fos by human papillomavirus type 11 E5a oncoprotein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibody developed against the c Jun and c Fos proteins inhibited the AP 1 binding activity to TRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNA for the transcription factors ATF 3 , c fos , c jun , junB , and zif / 268 is induced by A 23187 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reexposure to EGF produces high levels of synthesis of the early response genes , c myc , c fos , c jun , and MGSA , within 1 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fra 2 gene is related to the proto oncogene c fos and encodes a member of the AP 1 transcription factor gene family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun , which encode leucine zipper class transcription factors , was also studied . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
No relationship was observed between the expression of NGF gene and that of c fos , fos B , fra 1 , jun B proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction in AP 1 DNA binding correlates with a concomitant GH trans activation of c jun and c fos genes described previously . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of c Fos and c Jun redox dependent DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The response of c fos mRNA expression to stress and alcohol differed from the effects on jun B , c jun and jun D mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both DNFB and TPA caused marked induction of ODC , c fos and c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , the expression of c Fos , and C Jun proteins are only slightly affected by u . v . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is concluded , that neuragin is an immediate early gene product , similar to proteins encoded by genes c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JunB , but not c jun , mRNA expression was found under these conditions in addition to a transient c fos mRNA increase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , consistent with previous studies , the acute phase livers are induced for c jun but not c fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Subsequent to the phosphorylation of CREB , c Fos expression and the AP 1 complex are enhanced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that c fos and fosB successively occupy an AP 1 site like element of the TH promoter after nerve growth factor treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Besides various oxidants , phenolic antioxidants were shown to specifically induce expression of the c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ERKs are probably involved in the induction of c fos expression and thereby contribute to the stimulation of AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Meanwhile the transcription of c fos and c jun genes was up regulated beginning 3 hours after LDR . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dexamethasone action on c fos and c jun mRNA and protein in human lung . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Injuries to the brain induce rapid expression of c fos and c jun proto oncogenes in neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
VP 16 also stimulates c jun and c fos mRNA expression in some cell lines , including human leukemia K 562 and HL 60 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although CREB , c Fos , c Jun , and JunD did not have significant effects , JunB inhibited the Tax dependent transactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that both c Jun and c Fos are part of the protein complexes that bind to this sequence in SH SY5Y cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These include histone , jun B , c fos , collagen , fibronectin , osteocalcin , alkaline phosphatase , and osteopontin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Yet , nefenopin and cyproterone acetate induce hyperplastic responses in the liver with no induction of c fos , c myc , or c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Many immediate early serum response genes including c fos , c myc , and c jun are transcriptional regulators . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with these observations , both TNF and IFN beta increased c fos and c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Levels of c fos , c jun , zif 268 , and krox 20 mRNA were measured by Northern and slot blot analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription of a variety of genes , including c fos , c jun , and junB , is increased in these cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Association of the human c Jun and c Fos proteins depends upon interactions involving their leucine zipper domains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Madin Darby bovine kidney cell line expressed multiple cellular oncogenes , c jun , c myc , and c fos , and p 53 genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both in CG 4 and in cortical O 2A progenitors , basal mRNA levels of NGFI A were much higher than c fos , c jun , or jun b . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After HGF stimulation , HGF receptor expression follows c FOS and c JUN induction with a peak approximately 4 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The antioxidant mediated activation of AP 1 relies on the de novo synthesis of c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c fos gene product was detected in the AP 1 complex using anti c Fos antibody . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IGF 1 induced c fos and c jun expression in bovine chromaffin cells in primary culture . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , we study that mRNA levels of nuclear protooncogenes , c fos , c jun and c myc , in FdUrd treated cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The antisense oligonucleotide also strongly inhibited the amphetamine induced expression of c Fos and Jun B in striatal neurones . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
With SE there was also a weaker induction of c Fos and Jun B in dying neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 1 induced gene transcription of both AP 1 components , c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
USA 88 : 8332 8336 , 1991 ) and of two other bZIP proteins , c Jun and c Fos ( P . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A model implicating c fos and c jun is proposed . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our studies show that Bt2cAMP enhances the PMA induced c fos and jun B expression , but inhibits c jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription of c myc , c fos , and c jun in response to IGF 1 was inhibited by ethanol . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Only 5 fos can transform CHP 25 , whereas c fos , 5 myc , c jun and junB are ineffective . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When c fos and c jun mRNAs were investigated , only that of c fos was affected by PMA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
At 15 min to 1 h post IL 2 mRNA for c fos , c jun , and c myc , and TNF was induced in three individuals studied . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Additional experiments suggest that one result of PTK activation is the accumulation of c fos and c jun transcripts . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Epidermal growth factor ( EGF ) induced c fos and c jun expression is strongly suppressed in microgravity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Within 15 minutes of balloon injury , mRNA levels of c fos , fosB , c jun , junB , and junD were elevated severalfold . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TNF alpha induced expression of both early protooncogenes , c fos and c jun , in the cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TGF beta 1 did not affect induction of c myc expression by GM CSF or induction of c fos or c jun by M CSF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of AP 1 by PDTC was dependent on protein synthesis and involved transcriptional induction of c jun and c fos genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Accordingly , X 2 is recognized by the AP 1 factor and by other c Jun or c Fos containing heterodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition to effects on c fos mRNA , tamoxifen also increases uterine levels of c jun , jun B , and c myc mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibodies specific for Jun B , c Fos , Fos B and CREB failed to interact with either complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Adrenomedullin induces expression of c fos and AP 1 activity in rat vascular smooth muscle cells and cardiomyocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes c fos and c jun are induced by several tumor promoters . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Accordingly , the expression of early response genes like c fos , c jun and c myc was not blocked by the drugs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , PRL stimulates the gene expression of c fos , c jun , and c src . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , a reduced expression of c fos and c jun mRNA was noticed , combined with a reduced DNA binding activity of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Additionally , H2O2 increased the mRNA expression of MAPK dependent genes c jun , c fos , and MAPK phosphatase 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When Ba / F3 FF cells were stimulated with Epo or IL 3 , rapid induction of c myc , c fos , c jun and junB genes was observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel mobility shift assays showed that the c fos induced expression was coincident with an increase in AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
SRE 1 conferred Jun activation to a heterologous promoter , as did the c fos SRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both oxidative signals and anti CD 3 stimulation induced increased levels of c jun and c fos mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PRL had no effect on c jun mRNA accumulation under any of the experimental conditions employed in the c fos studies . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , recombinant GHF 1 interacted directly with c Jun but not c Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that cellular transcription factor AP 1 ( c Jun / c Fos heterocomplex ) bound to the 21 bp sequence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study shows that 1 kappa B alpha transcription is synergistically stimulated by Rel and AP 1 factors ( c Fos and c Jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PTH ( 1 34 ) immediately increased the transcript levels of c fos and c jun at a considerably higher rate than PTH ( 28 48 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , c fos and c jun mRNA levels are not regulated by EPO in FVA cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To address this issue , several protooncogenes , including K ras , N ras , erbB 2 , erbB 3 , c myc , c fos , c jun were examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Uncoupling of the pathways which link MAP kinase to c fos transcription and AP 1 in response to growth stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogene product c Fos , a component of the transcription factor AP 1 , is induced in early B lineage cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The early response genes such as c fos and c jun were induced by insulin even in the presence of YM 9429 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The UV A induced AP 1 binding complex is shown to contain c Fos and c Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The short term responses of activator protein 1 factors such as c fos and fos related antigens have been well studied . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Higher expression of c fos and c jun has also been demonstrated in multidrug resistant human and murine cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
No immunoreaction is found to c Fos , Fos related antigens and Jun B in these areas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of cells with TPA increased c fos mRNA 20 fold with only a 2 fold increase in c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of patient derived lipids on the expression of c jun , c fos , and c erbB 2 gene products were examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos and c jun was inhibited by both GM 3 and leflunomide . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Some types of cell death have been associated with expression of the immediate early genes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogene product c Fos , a component of the transcription factor AP 1 , is induced in early B lineage cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This might be related to the report that c fos or c jun activation may be important in some models of neurodegeneration . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis revealed that PDTC upregulated expression of c jun and c fos before the expression of stromelysin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These included c fos , c jun , Id 1 , Id 2 , E2F 1 , and cdc 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nrl was more effective than the related bZIP proteins , c Fos and c Jun , in stimulating rhodopsin promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Bradykinin stimulates c fos expression , AP 1 DNA binding activity and proliferation of rat glomerular mesangial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NAC suppressed NGF induced c fos gene expression and AP 1 activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further experiments suggested that this repression was due to overexpression of c Fos and Fra 1 , but not due to Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our results show a reduced binding of E2F and AP 1 proteins to the c fos promoter in aging hearts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EGF induced invasion is inhibited by both c fos and c jun antisense oligonucleotides . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However the proto oncogene encoding the AP 1 transcription factor subunit c Fos is induced by both prooxidants and antioxidants . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , TSO and CSO enhanced c jun but not c fos mRNA , which is in parallel with the HO 1 mRNA change . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , ET 1 increased the DNA binding activity of AP 1 containing c Jun and c Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
OSM increased c fos and c jun mRNA levels but did not stimulate DNA synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this report , we show that this inducible CyRE binding protein is composed of the AP 1 proteins c Fos , JunB , and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The calpain in the extract degrades also N myc , c Fos and c Jun , but not lysozyme . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Shift Western blotting indicated the presence of c Fos in the AP 1 complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Alterations in the expression of c jun and c fos were observed in NIH 3T3 and A 431 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cells express TrkB protein and show elevated c Fos and c Jun levels in response to BDNF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
USF specifically interacts with Fra 1 but not with other closely related family members , c Fos , Fra 2 , FosB , or with c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The components of the AP 1 transcription factor in particular , c Fos and Zif 268 have been widely used for this purpose . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : PSCs showed a high transcription of protooncogenes c fos , c myc and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This effect was followed by corresponding increase in serine 73 phosphorylation of c jun and transcription of c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have also shown previously that both CPPD and BCP crystals activate expression of the c fos and c jun proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Prolonged NGFI A expression , like c fos and c jun , seems to provide a marker for slowly dying neurons . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both c fos and c jun induction by the purine analogue could be fully prevented by pretreatment with suramin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : NECA and forskolin had no effect on AP 1 activation , c jun or c fos gene expression , or CREB phosphorylation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Footprint analysis confirmed that this site is capable of binding c Jun and c Fos in vitro . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
H2O2 treatment led to increases in c fos and c jun mRNA levels , Jun nuclear kinase activity , and AP 1 DNA binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It was shown that the ATF also can induce c myc , c jun , and c fos in osteoblastic cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
KCM was shown to increase the expression of the proto oncogenes c fos , c myc and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While Epo is known to activate c fos gene expression , the mechanism of AP 1 activation is unknown . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Lyso PC ( 25 micromol / L ) also increased the mRNA expression of c fos and c jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast to phorbol esters , bufalin does not significantly stimulate c jun or c fos mRNA expression or AP 1 transactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MPTP elicited an induction of c fos , fosB , Delta fosB and c jun mRNAs in the striatum that persisted for 24 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also found increased expression of AP 1 family members c fos and c jun by Northern blot analyses after treatment with LPS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the proto oncogenes c fos and c jun was enhanced in ATP treated animals as compared with controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis showed that the activated AP 1 complexes contained c Fos and c Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
HCG induced a rapid and transient expression of c fos , fosB , c jun , junB , junD and c myc with a peak at 30 min to 1 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The immediate early gene products , c Fos and c Jun , appear not to be determinants of this process . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the absence of FCS , c fos and c jun mRNAs were expressed only in transgenic cultures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift experiments revealed that JunD and c Fos proteins mediated anti CD 19 induced AP 1 binding activity in 1E8 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis showed that mRNA levels of c fos , c jun were elevated after treatment with ATP . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c jun and c fos was detectable in both mesenchyme and epithelium through the whole tract . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 2 induces a rapid tyrosine phoshorylation in MILG cells , which is followed by a prolonged induction of c fos and c jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C5a caused a significant up regulation of mRNA for the early response genes c jun and c fos on HMC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
GH treatment for 30 min down regulated c jun and c fos mRNA approximately 2 and 2 . 8 fold , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gastrin via its G protein coupled specific receptor induces transcription of c fos and c jun genes through a ras MAPK pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
LPS preconditioning induced the expression of c jun and c fos mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
D 609 alone induced c jun mRNA with the same potency as it repressed the NGF induced expression of c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MKP 1 inactivates MAP kinase and therefore may interfere with the activation of c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CONCLUSIONS : The c Jun and c Fos proteins are expressed differentially in hippocampal neurons after CPB and HCA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Assays testing the abilities of MT and ST to induce the c fos promoter and to activate c jun kinase led to the same conclusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis revealed H2O2 as well as TNFalpha induced AP 1 complexes containing c Fos and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
They include c Jun , Jun B , Jun D , c Fos and Fos related antigens . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , RING 1 overexpression results in enhanced expression of the proto oncogenes c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 10 also inhibited expression of IL 2 transcriptional regulators c fos and c jun , which also inhibit other cell functions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis revealed that immediate early genes , c myc , c fos and c jun are induced by mitogen in dense cultures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of c fos promoter by Gbetagamma mediated signaling : involvement of Rho and c Jun N terminal kinase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased expression of the genes for c Jun and c Fos but not for ODC occurred with EGF alone . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The immediate early genes ( IEGs ) , c jun , junB and c fos are expressed after global ischemia in the gerbil . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IE 1 expression did not raise levels of c jun and c fos RNA , as determined by quantitative RT PCR . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays revealed that fra 1 participates in the activator protein 1 complex together with c fos , c jun and junB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , co transfection of c fos and c jun expression vectors into VSMCs resulted in decrease in the NT 3 gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vivo , overexpression of c Jun , but not c Fos , leads to a rescue of the 1 , 25 ( OH ) 2D3 mediated repression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EGF induced c fos and c jun expression decreased in microgravity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These effects were preceded by a transient augmentation of junB , c fos and c jun mRNA contents . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Therefore , induction of c fos led to an activation of AP 1 in the presence of hemin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and activation of AP 1 by ouabain were not sensitive to NAC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , the mRNA levels of oncogenes ( Ha ras , c jun , and c fos ) were seen to decrease to varying degrees . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Within a few minutes of T cell activation , transcription of a set of genes including c fos and c jun is activated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Lovastatin reduced membrane bound p21ras and fetal calf serum induced c fos and c jun protein expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of COX 2 correlated more closely with the induction of c Jun than with that of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection with the c jun and c fos expression vectors stimulated the uPAR promoter activity four to fivefold . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TGF beta 1 addition causes an immediate and transient induction of c fos but not myc or jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
GA treatment led to a decrease in the nuclear content of c Jun but not that of c Fos or of activating transcription factor 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neuregulin induced expression of immediate early genes c jun and c fos , which followed and depended on the ERK activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Palmitate and oleate also increased c fos protein expression and DNA binding activity of the transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c maf proto oncogene encodes a basic leucine zipper protein homologous to c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ang 2 caused a rapid induction of immediate early genes ( c fos , c myc and jun B ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , antisense oligonucleotides to c fos and c jun were also protective . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These events were preceded by up regulation of c jun and c fos mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein products for c fos , fos b , c jun and jun b were displayed by immunocytochemistry . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hcy also induced the activity of serum response factor and expression of c fos and c jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blots showed an increase in the level of c jun , c fos , and bFGF mRNA during hypoxia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 complex induced by DCA consisted of JunD , Fra 1 , and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interestingly , this complex was not affected by the addition of any antibodies against ER , c Jun , c Fos , JunB , or JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After 30 min stimulation , the mRNA levels of c jun and c fos were also increased 20 and 36 fold , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Deformation rapidly induced the immediate early response genes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These mitogen activated protein kinase pathways regulate a number of transcription factors including c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 , a heterodimer of c FOS / c JUN , functions as a transcription factor of downstream gene ( s ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The activator protein 1 complex in human keratinocytes consists of dimers of Fra 1 , Fra 2 , c Jun , JunD , and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Messenger RNAs for c fos , c jun and jun B were also observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JunB , c Jun , c Fos , and Fra 2 were rapidly but transiently induced by FSH in immature granulosa cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DEX treatment of RAW 264 . 7 cells did not inhibit the nuclear translocation of c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The levels of c Fos increased during freezing in kidney and brain whereas c Jun was unaffected by freeze / thaw . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fra 1 is a c Fos related protein belonging to the AP 1 family of transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of immediate early genes c Fos and c Jun in small intestinal transplantation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CD 437 increased the expression of c Myc , c Jun , c Fos , and death receptors DR 4 , DR 5 and Fas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis suggests that activated AP 1 contained c Jun , JunD , c Fos , FosB , and Fra 1 subunits . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , CCM failed to affect DEN induced c Jun and c Fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The spatiotemporal pattern of c fos and c jun mRNA induction well correlates with the occurrence of seizures in D2R / mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These transcription factors include p 53 , c Myc , and AP 1 ( c fos and c jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While c Fos , Fra 2 and JunB were increased in response to either stimuli , only Fra 1 , c Jun and JunD were increased by PMA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By immunohistology , NF kappa B ( p 65 subunit ) and the c Fos subunit of AP 1 were localized primarily in vascular endothelium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A c fos antisense oligodeoxynucleotide ( ODN ) inhibited AP 1 , but not NF kappaB , activation after SCI . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AII induced cyclin D 1 promoter activity through a c Fos and c Jun binding sequence at 954 bp . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
For Northern analysis , RNA was isolated and c fos , cjun and TIEG expression assessed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Subsequently , curcumin inhibits the activation of NFkappaB and the expressions of c jun , c fos , c myc and iNOS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
HMBA induces c fos and represses cycloheximide induced c jun and fra 1 expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In parallel , PP1 / PP2 inhibited PRL induction of cell growth related genes c fos , c jun , c myc , and odc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis showed that MG 132 rapidly induced the expression of c jun , but not c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure to HNE caused ERK , JNK , and p 38 MAP kinase activation as well as the induction of c fos and c jun gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , the treatment also decreased the expression of c JUN , but had no effect on the levels of c FOS and c MYC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , PKC and AP 1 subunits c Jun and c Fos were also upregulated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proto oncogenes such as c fos , c jun and c myc are known to relate to cell proliferation and differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EGF induced c fos and c jun expression were decreased in microgravity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Signals from various chemical and physical stimuli are transmitted to the nucleus , and induce c fos and c jun gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JDP 2 binds DNA as a homodimer and heterodimer with ATF 2 and Jun proteins but not with c Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Alterations in the transcription of IEGs ( c fos and c jun ) were examined by Northern blotting . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , ascorbate increased the mRNA levels of c jun , junB , and c fos in 1 alpha , 25 ( OH ) 2D3 induced cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun is associated with phosphoacetylation of histone H 3 and acetylation of histone H 4 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Retinoic acid regulation of mu opioid receptor and c fos mRNAs and AP 1 DNA binding in SH SY5Y neuroblastoma cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both compounds suppressed the protein expression of c Jun , but not c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Indicators of cell proliferation ( c jun and c fos proteins and others ) increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our studies confirm the up regulation of c jun , jun B , c fos and cyclin D 1 by H . pylori . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There were no steroid associated changes in mRNA expression of c myc , c jun , c fos , proglucagon , or selected cytokines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Western blot analysis of AP 1 nuclear protein showed a reduced level of c Jun but not of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the protein level , we detected BN induced stimulation of the c fos gene product but not of c jun protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , AP 1 inhibition , with curcumin or c fos antisense oligonucleotide , reduced bim expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Matrix metalloproteinases in the adult brain physiology : a link between c Fos , AP 1 and remodeling of neuronal connections . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos but not c jun expression was also suppressed in the diabetic group but not closely linked to bone formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Smad 2 , 3 , and 4 and AP 1 complex ( c fos and c Jun ) cellular localization were evaluated by immunostaining . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Based on in vitro analyses , GnRH appeared to enhance the interaction of JunD , FosB , and c Fos at the GnRHR AP 1 element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the same period of time the AP 1 complex , augmented in CA 1 region , did not appear to contain a classical c Fos protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , DC potentiated the increased c Fos and c Jun protein levels in the hippocampus induced by KA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased transcripts of c fos , c jun , c ets , Hyal 1 , 2 , CD 44 , and caveolin 1 mRNAs were observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Smad 2 , 3 , and 4 and AP 1 complex ( c fos and c Jun ) cellular localization were evaluated by immunostaining . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The constitutively active mutants of PKC alpha and PKC epsilon also activated c fos , c jun , and cyclin E promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The inhibition of S phase induction was associated with down regulation of c Myc , but not of c Fos or c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we surveyed human lymphoma samples for expression of JunB and other AP 1 members ( c Jun , c Fos , Fra 1 , JunD ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos and the AP 1 activity were detected by immunoblotting and EMSA respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protection correlated with prevention of an increase in c Jun activation and c Fos transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c Jun and c Fos proteins were identified as components of the AA induced AP 1 complex and their levels were increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The increased AP 1 binding activity was accompanied by c Fos synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A supershift assay revealed that both c Fos and c Jun bind to this AP 1 site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of AP 1 proteins , consisting of c Fos and c Jun , in activated T lymphocytes was decreased by Cpd 6A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Typical immediate early genes such as c fos and c jun were not affected at this dose . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , an increase of c jun protein levels , but not of c fos , was also found after coexpression of CagA and HspB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our results reveal that c fos , fosB , c jun , and junB levels were upregulated at 24 hr . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
E 2 and E 2 BSA shifted the activator protein 1 composition from c Jun homodimers to c Fos / c Jun heterodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : mRNAs coding for transcription factors c jun , c fos and c myc were rapidly induced by injury . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The role of AP 1 in IL 12p40 transcription was confirmed by using antisense c fos and c jun oligonucleotides . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BK also stimulated translocation of p42 / p44 MAPK into nucleus and led to expression of c fos and c jun in CKs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest that a homogeneous 10 T SMF does not alter the expression of the c jun , c fos , and c myc protooncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Static stretch induced an increase in the expression of c fos , fosB , fra 1 , c jun , and junB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 complex is composed of c Jun and c Fos and is a key component in the regulation of proinflammatory genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c Jun , c Fos and JunD proteins were detected in the Sertoli cell nuclei , whereas apoptosis occurred in the germ cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Accordingly , increased levels of c Jun or c Fos , but not Jun B , Jun D or Fos B , lower the chglast promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure to CS caused a marked upregulation of c Jun , c Fos , and Fra 1 , but not of Fra 2 , Jun B , and Jun D expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Representative sections were immunostained for phosphotyrosine , phospho c Jun , Jun D , and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Resveratrol stimulated c fos and c jun expression in DU 145 cells , an effect also suppressed by EGF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We observed a prolonged c Fos and c Jun expression in basal ganglia motor and limbic circuits over 96 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proto oncogene , such as c fos , c myc , and c jun in humans , are associated with AREs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Lipopolysaccharide stimulated increase of c Jun and c Fos protein levels was also attenuated by EPA pretreatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
E 2 and P 4 increased , whereas T 4 and DHT reduced , the expression of parasite c fos and c jun and DNA synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , G 120 increased the expression of c Jun , Fra 1 , and Fra 2 , but did not affect the expression of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
GnRH induced recruitment of ATF 3 , c Jun , and c Fos to the dual CREs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein levels of c Jun , c Fos and pSTAT 3 confirmed the upregulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcripts for c jun and c fos were detected as early as 2 hours after UVB exposure and were suppressed by PD 98059 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoblotting confirmed a decrease in total and phosphorylated c myc , a decrease in c fos , and increases in c jun and p 53 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A down regulation of c jun , NF kappaB 1 , Max , Ets 1 , and p 53 mRNA , and an up regulation of c fos mRNA was noticed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos and c jun were also downregulated after 24 h and 6 h of treatment , respectively . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , Zn ( 2+ ) exposure of BEAS 2B cells induced the phosphorylation of the AP 1 proteins c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription of downstream c fos , AP 1 transactivation and cell proliferation were higher in the low catalase cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , it was found that COS repressed the gene expression of c fos , a part of AP 1 transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription factors c Fos and c Jun maximally responded within 1 h to all loading types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The findings suggest that activation of the Jun and Fos oncoprotein pathway is important for transformation by Ets . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun : inducible transcription factors regulating growth of normal and transformed cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos protein is a major component of the AP 1 transcription factor complex , which includes members of the jun family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Other nuclear factors such as fos and jun can influence vitamin D mediated gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 motif binds TPA and calcium ionophore induced nuclear factor ( s ) containing fos protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Coexpression of Ets 1 , Fos , Jun , or Myc with Myb did not increase trans activation of the mim 1 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The role of Jun , Fos and the AP 1 complex in cell proliferation and transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Redox regulation of DNA binding activity of fos and jun oncogene proteins in vitro ] . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulus transcription coupling in the nervous system : involvement of the inducible proto oncogenes fos and jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , the activation of other mitogen inducible transcription factors , such as Fos and Jun , was unaffected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , the induction of fos , jun , and myc by EGF and TPA was not significantly inhibited in this cell line . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Liver specific induction patterns of gene 33 , phosphoenolpyruvate carboxykinase , and the jun , fos , and egr families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear proto oncogenes fos and jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Heparin inhibits transcriptional activation by Fos and Jun oncoproteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These include the families of JUN , FOS , zinc finger proteins and nuclear hormonal receptors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Association of nuclear oncoproteins fos and jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun : the AP 1 connection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This later property influences the ability of DNA binding proteins , which include Fos and Jun , to bind to AP 1 complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos B , FRA 1 , FRA 2 , Jun B , Jun D , NGFI A ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun , in association with Ets , is capable of interacting with Fos family members to form a trimolecular protein complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition to Jun B , we found that the T cell AP 1 complex contains the Fra 1 protein , a member of the fos gene family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun proteins , has been widely investigated in this system . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos , c Jun , Krox 24 ) in dentate gyrus neurones . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Zen and the art of Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MafB , a new Maf family transcription activator that can associate with Maf and Fos but not with Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun 1 is also recognized by complexes containing Fos and Jun in vitro , but with only a very low affinity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Raf perinuclear translocation was also intact and comparable degrees of nuclear egr , fos , and jun expression occurred . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the transcription complex AP 1 , composed of Jun and Fos family members , can be induced by a variety of stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Addition of Fos protein to Jun Jif 1 complexes restores DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among proto oncogenes codifying for nuclear proteins , we focus on fos , jun , myc , and related genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The most crucial of these is a consensus AP 1 sequence , the binding site for the Fos and Jun families of transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One of the main nuclear targets of this signal transduction cascade is the Fos and Jun family of transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The amount of DNA protein complex was reduced by c Jun protein antiserum but was not altered when treated with a Fos antibody . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Members of the ATF , Fos , and Jun family are not immunologically detected in this inducible DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Indeed , exposure of cells to oxidants or UVC stimulated binding of Fos and Jun to the GADD 153 AP 1 element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is also a redox factor ( Ref 1 ) , stimulating DNA binding activity of AP 1 binding proteins such as Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The involvement of the Ah receptor , Maf , Nrl , Jun , Fos , and NF kappa B in GST induction is discussed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Jun proteins are nuclear proteins that combine with Fos proteins to form a gene regulatory protein , AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factor is a variable complex of Fos and Jun nuclear phosphoproteins that is induced in many cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro this region was able to bind a complex containing proteins recognized by antibodies against Jun or Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun mRNA and peptide exhibit a daily light induced rhythm in the suprachiasmatic nucleus ( SCN ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and Fos are examples of proteins that mediate mitogenic signals and influence differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The four members of the Fos gene family give rise to proteins that are part of the AP 1 transcription factor complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fos and jun families are frequently studied immediate early genes that are induced by KA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recently , GnRH has been shown to induce expression of immediate early genes of fos and jun family in adult rat gonadotrophs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is shown that dimer forming specificities of Maf 1 and Maf 2 to Jun or Fos family proteins are variable . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factor AP 1 , composed of Fos Jun dimers , mediates some aspects of the cellular response to growth factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of AP 1 ( jun and fos proteins ) also inhibited androgen induced PSA promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , staurosporine induced immediate early genes including Nur 77 and fos , but not jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thyrotropin ( TSH ) induces the expression of fos and jun family genes in thyroid cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have tested this system with two well known eukaryotic dimerization domains ( the Fos and Jun leucine zippers ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Upregulation of collagenase gene expression by IL 1 is known to require the transactivators Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Like other oncoproteins , such as Myc , Jun , and Fos , Tax is a transcriptional activator . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Upregulation of the fos gene and AP 1 transcriptional activity causes malignant conversion of benign keratinocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos protein forms the heterodimer AP 1 with the Jun protein and regulates the cell cycle by inducing cyclin D 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , the role of Fos , Jun and p 53 in cellular defense against alkylating mutagens is discussed . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Menin did not interact directly with other Jun and Fos family members . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , specific Jun and Fos transcription factors can transactivate HIV 1 provirus in human colon epithelial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun form a heterodimer known as activator protein 1 , which regulates the expression of many late effector genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , when Jun is present in the nuclear compartment , it is phosphorylated on Ser 63 and is complexed with Fos protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In similarity with several other oncoproteins such as Myc , Jun , and Fos , Tax is a transcriptional activator . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oncogenic transformation by ras and fos is mediated by c Jun N terminal phosphorylation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , no Fra 2 , Fos B or c Jun immunoreactivities were detected in these same synaptic regions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of other fos and jun proteins was not persistently altered in epilepsy . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and Fos , ATF 3 might play a role in the control of cell proliferation and participate in oncogenic transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These proteins include the Jun , Fos and ATF subgroups of transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and Fos proteins are induced and activated following most physiological and pathophysiological stimuli in the brain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we describe such a dimerization system based on engineered Fos and Jun leucine zippers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos functions as a subunit of the heterodimeric transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 site bound Jun and Fos proteins from HL 60 cell nuclear extract . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos dimerizes via a coiled coil ( leucine zipper ) with Jun family members to form the transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thiol alkylation inhibited PDGF BB induced expression of the Fos and Jun family proteins and AP 1 activity in VSMC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos and Jun proteins were localized by immunohistochemistry to hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Together with bZIP proteins of the Fos and Jun families , ATF 2 constitutes the AP 1 transcription factor complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
FGF 2 treatment also induced fos and jun mRNAs and later increased the nuclear levels of activator protein 1 ( AP 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : Here , we show that Fos and Jun , the two components of AP 1 , are abundantly expressed in motor neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factor is comprised of homo and heterodimers of the Fos and Jun families of proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These include members of jun or fos and early growth response ( EGR ) gene families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factor is mainly composed of Jun , Fos and ATF protein dimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among others , Fos , Jun , and EGR 1 were upregulated by the bacterial supernatant and by live bacteria . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Amongst all Fos and Jun family members examined , only were the levels of c Jun and Fra 2 consistently elevated by the ITCs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of Jun and Fos proteins were differentially regulated by TS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activating protein 1 is a dimeric complex composed of members of the Fos and Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the immediate early genes c fos , egr 1 and c jun in the accessory olfactory bulb during the formation of an olfactory memory in mice . ^^^ In this study we have examined the expression of the immediate early genes c fos , c jun and egr 1 in the mitral and granule cells of the accessory olfactory bulb immediately after mating , during the period of memory formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ACTH increases expression of c fos , c jun and beta actin genes in the dexamethasone treated rat adrenals . ^^^ Since FOS functions only when it dimerizes with JUN ( the product of c jun gene ) , the changes in the levels of c fos and c jun mRNAs were studied together with that of beta actin mRNA which is also affected by ACTH . ^^^ It was demonstrated that ACTH increases the mRNAs coding c fos and c jun in the adrenal glands of dexamethasone treated , ACTH suppressed rats . ^^^ These results suggest that increased expression of c fos , c jun and beta actin genes by ACTH may play an important role in mediating its action on the adrenals . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional activation of the c jun , junB and c fos genes following TPA / serum induction was unaffected and efficient transactivation of AP 1 reporter constructs was demonstrated in these cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This suppression was temporally preceded by rapid and transient up regulation of c jun and c fos genes . ^^^ Furthermore , co transfection of the elastin promoter construct with c jun and c fos expression plasmids resulted in a marked decrease in the promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gonadotropin induces expression of c fos and c jun genes in rat ovaries . ^^^ It has been shown that the expression of protooncogenes , c fos and c jun , induced by growth factors and hormones plays important roles in cellular proliferation , tissue differentiation and transcription of certain genes . ^^^ Since gonadotropin stimulates ovarian steroidogenesis and cellular proliferation , we investigated whether gonadotropin affects the expression of c fos and c jun genes in rat ovaries . ^^^ Changes in the levels of c fos , c jun and P450scc mRNAs were determined by Northern blot analysis . ^^^ The levels of c fos and c jun mRNAs increased rapidly and transiently with the peak levels at 15 min after PMSG administration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Identification of Fos target genes by the use of selective induction systems . c Fos is a major component of the transcription factor AP 1 which has been implicated in the control of cell proliferation and differentiation as well as in transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Noxious stimuli such as electrical C fibre stimulation , noxious skin heating or subcutaneous formalin injection result in the transsynaptic induction of the IEG encoded proteins c Fos , C Jun and Krox 24 , in the dorsal horn of the spinal cord . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We studied an effect of deregulated c fos , a component of AP 1 , in the expression of IL 2 gene in T cells by using splenic T cells from transgenic mice carrying the exogenous c fos gene under the control of the H 2 Kb promoter ( H 2 c fos ) . ^^^ Levels of AP 1 and IL 2 kappa B transcription factors in the nuclear extract from the H 2 c fos T cells were also augmented . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The relationship between cell proliferation and mRNA levels of the immediate early genes c fos , c jun , and jun B has been investigated in two clones of 3T3 fibroblasts ( D 1 3T3 and N 2 3T3 ) upon treatment with basic fibroblast growth factor ( bFGF ) , thrombin , phorbol 12 myristate 13 acetate ( PMA ) and dibutyryl cyclic AMP ( Bt2cAMP ) . ^^^ In spite of variable mitogenic response , immediate early genes , c fos , c jun , jun B , and c myc , were induced by the growth factors and by PMA in both cell clones . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have shown that the Z gene product , which binds to AP 1 sites as a homodimer and has sequence similarity to c Fos , can efficiently activate the EBV early promoter , BMRF 1 , in certain cell types ( i . e . , HeLa cells ) but not others ( i . e . , Jurkat cells ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis was used to determine the levels of collagenase c fos and c jun message . ^^^ Increased levels of collagenase message were preceded by an increased accumulation of c fos , but not c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of c fos , c jun and jun B messenger ribonucleic acids by angiotensin 2 and corticotropin in ovine and bovine adrenocortical cells . ^^^ We have investigated the effects of ACTH and A 2 on the levels of c fos , c jun , and jun B messenger RNAs ( mRNAs ) , in bovine and ovine ( OAC ) adrenal fasciculata cells . ^^^ In both cell types ACTH produced time ( maximum at 1 h ) and dose dependent ( ED 50 congruent to 10 ( 12 ) M ) increase in c fos ( 2 to 4 fold ) and jun B ( 10 to 20 fold ) mRNA levels but did not affect c jun . ^^^ A 2 also produced a dose dependent increase in c fos and jun B mRNAs but also in c jun in both cell types , despite the fact that OAC are resistant to the steroidogenic action of the hormone . ^^^ The stimulatory effects of A 2 on c fos mRNA were higher than those produced by ACTH , whereas the effects on jun B were similar but ACTH abolished ( OAC ) or decreased ( bovine adrenal fasciculata cells ) the stimulatory effects of A 2 on c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Accordingly , the effect of low K+ on mRNA abundances of four proto oncogenes ( c fos , c myc , c jun and c ski ) was evaluated in the early phase of the response by quantitative Northern blot analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Leukotriene B 4 stimulates c fos and c jun gene transcription and AP 1 binding activity in human monocytes . ^^^ We have examined the effect of leukotriene B 4 ( LTB 4 ) , a potent lipid proinflammatory mediator , on the expression of the proto oncogenes c jun and c fos . ^^^ The c jun mRNA , which is constitutively expressed in human peripheral blood monocytes at relatively high levels , was also slightly augmented by LTB 4 , although to a much lower extent than c fos . ^^^ The kinetics of expression of the two genes were also slightly different , with c fos mRNA reaching a peak at 15 min after stimulation and c jun at 30 min . ^^^ Stability of the c fos and c jun mRNA was not affected by LTB 4 , as assessed after actinomycin D treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we show that the growth factor inducible proto oncogenes c fos , c jun , and junB mimic the effects of exogenous growth factors and suppress trans activation of the muscle creatine kinase ( MCK ) enhancer by myogenin and MyoD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of expression of genes encoding transcription factors : c fos and c jun and formation of AP 1 transcriptional complex in human monocytes was investigated . ^^^ It was found that lipopolysaccharide induced strongly both c fos and c jun expression as well as AP 1 formation . ^^^ Interferon gamma activated strongly c fos and weakly c jun and AP 1 . ^^^ Tumor necrosis factor induced slightly c fos and had almost no effect on c jun and AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ET isopeptides induced a subset of fos and jun mRNAs in mesangial cells , including c fos , fra 1 , c jun , and JunB . fos and jun mRNAs were induced as members of the immediate early gene response . ^^^ Activation of the high affinity ET receptor moderately increased c fos and fra 1 mRNA , whereas activation of the low affinity receptor markedly induced both fos and jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that okadaic acid treatment of U 937 cells induces immediate increases in total cellular levels of both c jun and c fos mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of oncogene c fos and c jun expression has shown the enhancement of expression of both protooncogenes prior to CSF 1 , suggesting that the expression of these two oncogenes may be the mechanism which triggers CSF 1 gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , in differentiation medium , the induction of c fos , c jun , and fos B mRNAs by okadaic acid was transient , whereas fra 1 , jun D , and jun B mRNAs were induced continuously , suggesting that okadaic acid regulates the expression of the c fos and jun family through complex regulatory mechanisms depending on the state of differentiation of the cells . ^^^ Transfection of c jun and c fos promoter chloramphenicol acetyltransferase constructs demonstrated that the effects of okadaic acid on the induction of c fos and c jun are mediated through the activation of promoter elements . ^^^ Since it has been reported that transformation by c fos also inhibits myogenesis through inhibition of MyoD 1 expression , we examined the effects of okadaic acid on the activation of the c fos and jun family of proto oncogenes in an attempt to understand the mechanism by which okadaic acid inhibits the myogenic differentiation . ^^^ Treatment of C2C12 cells in growth medium with okadaic acid increased expression of the mRNAs for the c fos family continuously and for the jun family to a lesser extent . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These studies demonstrate that acid activation of the Na / H antiporter requires protein kinase C and is associated with c fos and c jun expression and increased AP 1 activity . . ^^^ This was associated with transient increases in c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 1 induces c fos and c jun gene expression in T helper type 2 cells through different signal transmission pathways . ^^^ We have analyzed the signal transmission pathways activated by IL 1 in these cells , leading to the expression of c jun and c fos . ^^^ In addition , phorbol esters did not induce c jun mRNA expression , whereas c fos mRNA expression mediated by IL 1 dependent on PKC ; this pathway was linked to a different , still unidentified IL 1R that was functional in the D10A cell line . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
LIF has no effect on the mRNA levels for retinoic acid receptor ( RAR ) alpha , RAR beta , RAR gamma , jun A , jun D , c fos , or fra 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We studied levels of mRNAs for several immediate early genes : c fos , NGFI A , NGFI B , c jun , junB and junD , before and after light exposure at these phases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of AP 1 DNA binding activity and c fos mRNA by the adenovirus 243R E1A protein and cyclic AMP requires domains necessary for transformation . ^^^ The 243R E1A protein can act in synergy with cyclic AMP to induce AP 1 DNA binding activity and c fos mRNA in mouse S 49 cells . ^^^ Binding of p 300 , p 90 , and the 120 to 170 kDa proteins was abolished in cells expressing mutants of E1A that were unable to induce AP 1 DNA binding activity and c fos mRNA . ^^^ These data strongly suggest that specific cellular E1A binding proteins are involved in the induction of AP 1 DNA binding activity and c fos mRNA by the synergistic action of the 243R E1A protein and cyclic AMP and that these transcriptional events are related to the transformation process . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Adenovirus E4orf4 protein reduces phosphorylation of c Fos and E1A proteins while simultaneously reducing the level of AP 1 . ^^^ Phosphorylation dependent alterations in the activity of c Fos , E1A , or some unidentified protein might , then , lead to decreased synthesis of AP 1 components . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation with substance P ( SP ) resulted in 1 ) a rapid increase in inositol 1 , 4 , 5 trisphosphate ( IP 3 ) synthesis ; 2 ) a rise in cytosolic free calcium concentration ( [ Ca2+ ] 1 ) ; 3 ) induction of immediate early gene transcription as monitored by c fos and c jun expression ; and 4 ) a significant increase in de novo DNA synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine whether the increases in c fos and c jun mRNA induced by carbachol and thrombin are sufficient to stimulate AP 1 mediated transactivation , 1321N1 cells were transfected with a reporter carrying two copies of the tetradecanoyl phorbol acetate response element and the firefly luciferase gene . ^^^ These findings suggest that rapid and transient conduction of c fos and c jun mRNA is insufficient to induce prominent changes in gene transcription , while the sustained increase in c jun mRNA and perhaps the late induction of fra 1 mRNA are required for generation of AP 1 DNA binding activity and transactivation through AP 1 . . ^^^ Activation of either muscarinic cholinergic or thrombin receptors increases phosphoinositide turnover , Ca2+ mobilization , and redistribution of protein kinase C and induces rapid transient increases in c fos mRNA and c jun mRNA in 1321N1 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of HMC to LDL resulted in a transient elevation of mRNA that encodes c fos and c jun , with a maximal effect seen after 30 60 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis of mRNA from UMR 106 01 cells treated for 3 h with 2 microM PGE 2 , 10 nM PTH , or 10 ng / ml EGF in the presence of cycloheximide demonstrated that all three agents induced the expression of c fos and c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Together with our previously published data , these results suggest that c jun can be induced independent of protein kinase C activation , without involvement of pertussis toxin sensitive G protein , independent of induction of c fos , and without expression of high levels of intracellular polyamines . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In good accordance with the induction of large T , endogenous c jun but not c fos or c myc mRNA was induced , whereas the expression of myoD and myogenin was suppressed . ^^^ Treatment of quiescent C 2 cells with a tumor promoter , 12 O tetradecanoylphorbol 13 acetate , transiently induced c jun and c fos mRNAs , and temporarily deinduced myoD and myogenin mRNAs just after the expression of the protooncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In adult rats , expression of c JUN , JUN B , JUN D , c FOS , FOS B , KROX 24 and CREB proteins was investigated by immunocytochemistry in L 4 and L 5 dorsal root ganglia and lumbar spinal cord for up to 300 days following transection of the left sciatic nerve . ^^^ JUN B , c FOS , FOS B and KROX 24 were not induced either following axotomy or following a repeated nerve crush . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of c fos and c jun gene expression and down regulation of proenkephalin gene expression in C 6 glioma cells by endothelin 1 . ^^^ Treatment of C 6 cells with endothelin 1 caused a rapid and transient 5 fold increase in c fos and c jun mRNA levels , followed by a decrease at 4 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Il 1 beta elicited a dramatic induction of c fos mRNA and a slight elevation of c jun mRNA in a time dependent manner which may allow for a role in the induction of NGF mRNA expression . ^^^ Moreover , the induction of c fos and c jun may represent a final common path in activation of NGF gene expression by different signals such as Il 1 beta and PMA . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In early passage cells , treatment with the beta adrenergic agonist , isoproterenol ( IPR ) , resulted in an increase in c fos mRNA and a decrease in c jun mRNA ( Gu bits RM , Yu H : J Neurosci Res , 30 : 625 630 , 1991 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrate interaction between the AP 1 constituents c fos and c jun and thyroid hormone receptor in this region by transient transfection experiments using a 125 to +37 bp hTSH beta fragment . ^^^ The proto oncogenes c fos and c jun modulate thyroid hormone inhibition of human thyrotropin beta subunit gene expression in opposite directions . ^^^ T 3 inhibition was completely abolished by c jun , but increased threefold by c fos . ^^^ Thus , c fos and c jun influence T 3 inhibition of hTSH beta expression in opposite directions acting through a response element shared with thyroid hormone receptor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we have therefore examined the effect of the phorbol ester PMA ( phorbol 12 myristate 13 acetate ) which stimulates PKC and a combination of the adenosine receptor agonist NECA ( 5 ' ( N ethyl ) carboxamido adenosine ) and forskolin to raise cAMP , on the levels of c Fos and Jun and on the binding and transcriptional activity of the transcription factor , activator protein 1 ( AP 1 ) . ^^^ Activation of protein kinase C and elevation of cAMP interact synergistically to raise c Fos and AP 1 activity in Jurkat cells . ^^^ Both PMA and the combination of NECA and forskolin acted together either to increase ( c Fos ) or decrease ( Jun ) protein levels as well as increasing AP 1 binding , as judged by gel shift assay , and AP 1 transcriptional activity . ^^^ PMA treatment caused a concentration and time dependent increase in both c Fos and Jun immunoreactivity in contrast to cAMP elevation that had only a slight effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential expression of early response genes , c jun , c fos , and jun B , in A 5 cells . ^^^ We examined the expression of c fos , c jun , and jun B after activation of different signal transduction pathways in the A 5 rat salivary epithelial cell line . ^^^ While c fos and jun B mRNA levels increase early ( 1 h ) after stimulation and transiently , those of c jun remain higher than control even after stimulation for 8 h and return to basal levels by 24 h . ^^^ Inhibitors of protein kinase C block the effect of PMA on c fos , c jun , and jun B expression , indicating that these genes are also regulated by a protein kinase C mediated mechanism in A 5 cells . ^^^ Exclusion of serum from the medium does not change the effects of isoproterenol or PMA on c fos , c jun , or jun B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In primary cultures of bovine glomerulosa cells , AII was found to induce the expression of several early growth response genes ( c fos , c jun , JunB , and Krox 24 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In MCF 7 cells , OA elicited within 5 min an increase in the levels of a set of phosphorylated cellular proteins , within hours expression of the early response genes junB , c jun , and c fos , and within days manifestation of differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Calpain participates in the transcriptional regulation by controlling the levels of transcription factors , c Jun and c Fos . ^^^ Modulation of cellular signal transduction by controlling the levels of the component proteins , such as PKC , c Jun and c Fos is one of the important physiological roles of calpain . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have studied the effect of excitatory amino acids on the expression of mRNA for the immediate early genes c fos , c jun , jun B , and NGF 1A in isolated cortical astrocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have shown that protooncogenes , c jun and c fos , whose products form heterodimeric transcription activator , AP 1 , strongly stimulate polyomavirus DNA replication through the AP 1 site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To elucidate some of the initial events which lead to this upregulation , we studied the acute effects of dopamine D 2 agonists and antagonists on the expression of c jun and c fos . ^^^ P . of haloperidol ( 2 mg / kg ) produced a rapid and transient increase in c jun and c fos mRNA in the rat striatum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos is a proto oncogene that encodes a 55 , 000 mol . wt phosphoprotein , Fos , which is thought to assist in the regulation of `` target genes ' ' containing an AP 1 binding site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Glutamate increased c fos , c jun , jun B , and NGFI A ( zif / 268 ) mRNAs by binding to both alpha amino 3 hydroxy 5 methylisoxazolepropionic acid ( AMPA ) and N methyl D aspartate ( NMDA ) receptor types , and increased c fos , jun B , and NGFI A mRNAs by binding to the metabotropic receptor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the protein products of the immediate early genes c fos , Fos B , Fos related proteins ( FRAs ) , c jun , jun B , jun D and krox 24 was investigated in the rat hippocampus at various times after electrically induced hippocampal seizures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
If this were the case , then c fos would be expected to act in concert with c jun to control transcription by binding to a specific DNA regulatory site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The acute effects of dopamine D 2 antagonists and agonists on the expression of c jun , zif 268 , ETR 101 and c fos in the rat striatum were studied . ^^^ A single injection IP of haloperidol ( 2 mg / kg ) or sulpiride ( 100 mg / kg ) produced a rapid and transient increase in c jun , zif 268 and c fos mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Changes in mRNA levels of the proto oncogenes c fos and c jun were examined 1 h after injection of reserpine by in situ hybridization and compared to the pattern observed for the Fos protein immunohistochemically . ^^^ C fos and c jun proto oncogene activation was observed 1 h after reserpine in the locus ceruleus and adrenal medulla , specifically in those catecholaminergic structures that respond with increased enzyme gene transcription ; in contrast , the dopaminergic neurons of the substantia nigra did not exhibit detectable proto oncogene activation , only a small group of neurons in the ventral tegmental area showed c fos without concomitant c jun expression after reserpine . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The majority of patients with IgA nephropathy showed elevated c myc , c fos , c jun , c raf , PCNA , perforin , PDGF B chain , and IGF 1 and 2 mRNA expression in PBMC , while no these mRNA expression was detected in PBMC obtained from patients with other types of glomerulonephritis or normal controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A transient and coordinated increase in mRNA levels for c fos , c jun , jun B , TIS 7 / PC 4 , TIS 8 / egr 1 , and TIS 11 occurred during the first 2 h of treatment with granulocyte colony stimulating factor ( G CSF ) , which ultimately induces the 32DC13 ( G ) cells to terminally differentiate into neutrophilic granulocytes . ^^^ Induction of the mRNAs for c jun and TIS 7 / PC 4 was blocked by the presence of 5 abl , whereas 5 ras caused constitutive expression of c fos mRNA and blocked the c jun , jun B and TIS 7 / PC 4 mRNA response . ^^^ Release of the differentiation block in the ras transformed 32DC13 ( G ) cells by co treatment with retinoic acid and G CSF partially restored the normal c fos and c jun mRNA induction pattern , suggesting that the proper activation of these genes may be important for myeloid differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun ( c jun , jun B and jun D ) and fos ( c fos , fos B and fra ) proteins dimerize to form the family of AP 1 transcriptional activators . ^^^ These hematopoietic progenitor lines become quiescent in G0 / G1 after interleukin 3 ( IL 3 ) deprivation , and upon stimulation synchronously enter the cell cycle . 32D cells respond to IL 3 with rapid induction of jun B and c fos , followed by induction of jun D and fra 1 , but no rise in c jun expression . ^^^ Jun ( c jun , jun B and jun D ) and fos ( c fos , fos B and fra ) proteins dimerize to form the family of AP 1 transcriptional activators . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using Northern and slot blot analysis of total RNA isolated from visual cortex , frontal cortex , and cerebellum of cats , we have determined the postnatal development patterns of mRNA expression for 5 of these genes , c fos , erg 1 , c jun , jun B , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Insulin resulted in an early and prominent increase in the transcription of genes encoding the AP 1 components of JunA , JunB , and c Fos , as has been observed for other growth factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One hour after left nephrectomy , c jun and c fos mRNA levels in renal cortex increased rapidly and then decreased rapidly to the control level , whereas c myc and PCNA mRNA levels showed a slower and more sustained increase , with a peak at 6 h after nephrectomy , and then decreased to the control level after 7 days . mRNA levels for basement membrane components including alpha 1 chain of type 4 collagen , laminin B 1 and B 2 chains , and heparan sulfate proteoglycan core protein were significantly increased in renal cortex at 12 h after nephrectomy , whereas those for interstitial collagens including alpha 1 chains of type 1 and type 3 collagen were unchanged following nephrectomy . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional run on assays revealed that treatment of serum starved NKM 1 with 50 ng / ml G CSF or M CSF increased the transcription rate of the junB gene and the c fos gene by 1 . 8 fold and 2 . 9 fold , respectively , but did not induce any transcript of the c jun gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The changes in TF mRNA occur in a similar time scale and at similar E 2 doses as the increases in the uterine proto oncogenes c jun and c fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A role for the Na / K ATPase in the control of human c fos and c jun transcription . ^^^ Results presented in this paper show that ouabain , a specific inhibitor of the Na / K ATPase increases the transcription of c fos , as well as c jun , in a variety of cultured cells . ^^^ However , in contrast to other agents that induce c fos and c jun expression , the increased transcription rate of these genes in the presence of ouabain required several hours and remained elevated for at least 16 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Abundant constitutive expression of c myc , c jun , and c fos was observed in the p210BCR / ABL transfectants even in low serum conditions . ^^^ In contrast , c myc expression in H 7 cells was dependent upon IL 3 stimulation , and neither c jun nor c fos was highly expressed following IL 3 stimulation in H 7 cells . ^^^ Thus , BCR / ABL transformation and relief of IL 3 dependence involve not only pathways that can substitute for IL 3 induced growth via tyrosine kinase mediated signals , but also pathways that recruit constitutive c jun and c fos expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , RAR alpha overexpression selectively inhibits the serum stimulated expression of the c fos gene , but does not affect the expression of a number of other serum and polyomavirus inducible genes including c jun , junB , c myc and actin . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have demonstrated that Ang 2 , when added to quiescence cultures of vascular smooth muscle cells , results in the rapid induction of the early growth response genes c fos , c myc , and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear oncogenes c jun , c fos and c myc are ' immediate early ' genes also activated during the proliferative response of hepatocytes . ^^^ C jun , c fos and c myc mRNA steady state levels in total cellular RNA were increased from 30 min 2 h after EGF stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the transin , c fos , and c jun genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas . ^^^ The expression of the transin , c fos , and c jun genes was assessed in transplantable osteosarcomas and malignant fibrous histiocytomas , as well as in pancreatic duct adenocarcinomas and hepatocellular carcinomas of rats and hamsters . ^^^ The primary SOS and MFH expressed both c fos and c jun genes in conjunction with the transin gene , whereas the non transin expressers , a 4 HAQO induced osteosarcoma ( COS ) and the pancreatic duct adenocarcinomas , demonstrated one or the other , but not both . ^^^ Expression of the c fos and c jun genes may play a regulatory role in this process . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proto oncogene c jun and c fos messenger RNAs increase in the liver of carnitine deficient juvenile visceral steatosis ( jvs ) mice . ^^^ We determined the mRNA levels of c jun and c fos in the liver of C3H H 2 degrees jvs mice . ^^^ Proto oncogene c jun and c fos messenger RNAs increase in the liver of carnitine deficient juvenile visceral steatosis ( jvs ) mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 complex and c fos transcription are involved in TPA provoked and trans synaptic inductions of the tyrosine hydroxylase gene : insights into long term regulatory mechanisms . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We studied the expression of six nuclear proto oncogenes ( Egr 1 , c fos , fosB , c jun , junB , and c myc ) in myocardium subjected to ischemia and reperfusion in anesthetized pigs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A 2 fold increase in zif 268 mRNA was seen , while increases in c fos and c jun mRNA levels were inconsistent , gamma Aminobutyric acid A receptor beta 1 subunit mRNA levels increased 3 fold . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Time dependent and cell density dependent changes in the transcription of c fos , c jun , c myc and protein kinase C ( beta form ) have been observed and quantitated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In inducing c jun , which works coordinately with c fos in transcriptional regulation , the effect of GH was additive with that of IGF 1 and synergistic with that of serum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mucosal samples were snap frozen and subsequently stained with monoclonal antibodies to the following oncogene associated proteins ; c erbB 2 ( neu and CE 1 ) ( external domain ) , c erbB 2 ( NCL CB 11 ) ( internal domain ) , c src , c ras , c myc , c fos , c jun , and the onco suppressor gene p 53 . ^^^ In Barrett ' s epithelium , nine specimens were positive for c erbB 2 ( neu and CB 11 ) , three were positive for c src , two were positive for c ras and c jun , and one was positive for c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the mechanism ( s ) by which all transretinoic acid ( RA ) inhibits cell growth , we studied its effect on the expression of c fos and c jun in B 16 melanoma cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 proteins ( c fos and fos related antigens and jun proteins ) are transcription factors that are induced in most cells by various stimuli , but the expression of these proteins is low or undetectable in the basal state . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , the influence of amygdala kindling on levels of mRNA for the immediate early genes ( IEGs ) c fos , c jun , and NGF 1 A were examined both before and after an acute electroconvulsive seizure ( ECS ) . ^^^ The influence of kindling on IEG expression was long lasting because an acute ECS stimulus significantly elevated levels of c fos and c jun mRNA in the cerebral cortex of animals that were kindled 5 months previously . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
LRF 1 / c Jun , c Fos / c Jun , and c Fos / JunB activate specific AP 1 and ATF site containing promoters , and in contrast , LRF 1 / JunB potently represses c Fos and c Jun mediated activation of these promoters . ^^^ As the relative level of LRF 1 / JunB complexes increases posthepatectomy , c Fos / Jun mediated ATF and AP 1 site activation is likely to decrease with simultaneous transcriptional activation of the many liver specific genes whose promoters contain cyclic AMP response element sites . ^^^ Interactions among LRF 1 , JunB , c Jun , and c Fos define a regulatory program in the G 1 phase of liver regeneration . ^^^ In regenerating liver , a physiologically normal model of cell growth , LRF 1 , JunB , c Jun , and c Fos among Jun / Fos / LRF 1 family members are induced posthepatectomy . ^^^ In liver cells , high levels of c Fos / c Jun , c Fos / JunB , LRF 1 / c Jun , and LRF 1 / JunB complexes are present for several hours after the G0 / G1 transition , and the relative level of LRF 1 / JunB complexes increases during G 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antisense c jun and c fos co transfection experiments further demonstrate the lack of a role for AP 1 in GPEI mediated trans activation in F 9 cells , although endogenously present AP 1 can influence GPEI in HeLa cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of wt p 53 protein on the expression of four immediate early genes ( c FOS , c JUN , JUN B , and c MYC ) , one delayed early gene ( ornithine decarboxylase ) , and two late G1 / S phase genes ( B MYB and DNA polymerase alpha ) was also examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CCK , bombesin , and carbachol stimulate c fos , c jun , and c myc oncogene expression in rat pancreatic acini . ^^^ To identify possible nuclear signals mediating long term regulation of the pancreas by gastrointestinal hormones , the expression of c fos , c jun , and c myc was investigated in rat pancreatic acini . ^^^ The percent increases of c fos , c jun , and c myc mRNA were 207 + / 40 , 171 + / 26 , and 46 + / 19 ( n = 5 ) for CCK 8 ; 223 + / 71 , 159 + / 31 , and 43 + / 21 ( n = 5 ) for bombesin ; and 125 + / 51 , 123 + / 58 , and 67 + / 19 ( n = 5 ) for carbachol , respectively . ^^^ CCK induced increases in oncogene mRNA were rapid and transient . c fos and c jun mRNA levels were increased after 30 min stimulation , peaked at 1 h , and returned to basal level in 2 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The finding that c fos is not coinduced suggests that c Jun homodimers or other AP 1 heterodimers may be formed at the PGA state to facilitate the stable induction of c jun mRNA . ^^^ We evaluated the ability of these and other agents to induce the expression of a variety of transcription factor genes including c fos , c myc , junB , and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present paper describes the effect of capsaicin induced stressful stimulus on the expression of immediate early genes ( IEGs ) c fos , c jun , junB and junD in the hypothalamic paraventricular nucleus ( PVN ) and the central amygdaloid nucleus ( ACe ) using in situ hybridization . ^^^ Stress caused an intense expression of c fos , c jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Diminished expression of c fos and impaired formation of AP 1 , which is a complex of c Fos and c Jun proteins acting as a transcription factor , was found in lymphocytes derived from old ( > 18 months ) mice and stimulated with Con A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Angiotensin 2 induced expression of proto oncogene ( c fos , jun B and c jun ) mRNA in bovine adrenocortical fasciculata cells ( BAC ) is mediated by AT 1 receptors . ^^^ We have shown previously that angiotensin 2 ( A 2 ) controls proto oncogene ( c fos , jun B and c jun ) mRNA accumulation in bovine adrenal fasciculata cells ( BAC ) . ^^^ DUP 753 , but not CGP 42112A , inhibited the stimulatory effect of A 2 on proto oncogene mRNA , with ID50s of 4 10 10 ( 7 ) M , 7 10 10 ( 7 ) M and 2 10 10 ( 6 ) M for c fos , jun B and c jun , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also show that c Fos does not affect the inhibitory function of CREM on c Jun and that the transcriptional activation elicited by the other members of the jun family ( JunB , JunD , and 5 Jun ) is also down regulated by CREM . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with this proliferative phenotype , the immediate early cell division cycle genes c fos and c jun were constitutively expressed in each cell strain prepared from injured lungs , but not in those from control lungs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cell proliferation and the expression of the protooncogenes c fos and c jun have been examined in the primary cultures of oligodendroglial ( OL ) progenitor cells in response to phorbol 12 myristate 13 acetate ( PMA ) , serum , insulin , insulin like growth factor 1 ( IGF 1 ) , platelet derived growth factor ( PDGF ) , and fibroblast growth factor ( FGF ) . ^^^ It was found that all of the agents tested stimulated DNA synthesis in OL progenitors and induced a rapid increase in c fos and c jun protooncogene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos , c jun and jun B in peripheral blood lymphocytes from young and elderly adults . ^^^ The expression of c fos , c jun and jun B proto oncogenes was studied in phytohemagglutinin ( PHA ) activated peripheral blood lymphocytes ( PBL ) from young and aged humans . ^^^ Specific mRNAs for c fos and c jun were detectable within 30 min after cell activation and reached maximal levels within 2 h . ^^^ Both c fos and jun B mRNAs decreased to pre activation levels within 6 h , while c jun mRNA remained elevated . ^^^ These results suggest that the decreased IL 2 production and proliferative response displayed by PHA activated PBL from elderly adults may be related to age related changes in c jun mRNA expression and in the ratio of c fos to c jun mRNA . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we co inject RB protein with c myc , EJ ras , c fos or c jun protein . ^^^ Co injection of c myc , but not EJ ras , c fos or c jun , inhibits the ability of Rb to arrest the cell cycle . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential induction of c fos and c jun proto oncogenes and AP 1 activity by tumor promoter 12 O tetradecanoyl phorbol 13 acetate in cells at different stages of tumor promotion in vitro . ^^^ Induction of c fos and c jun proto oncogene expression increased two to threefold in T 12 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The twenty four base pairs of the hARE contains an essential cis element AP 1 binding site and has been shown to bind to jun D and c fos proteins from mouse hepatoma ( Hepa 1 ) nuclear extract . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of neither c jun nor c fos expression vector , nor both vectors , could enhance the CAT activity , even though GPEI consists of two phorbol ester response element like sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the early response genes junB , c fos , and c jun was attenuated in PMA treated HL 525 and HL 534 cells as compared to the PMA treated HL 60 and HL 205 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When CSF 1R bearing cells expressing the Ets LacZ protein were stimulated by CSF 1 , induction of c ets 2 , c jun , and c fos ensued , but the c myc response was impaired . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thus , treatment of cells with TPA results in a reduction in the levels of c myb and c myc mRNA , while the expression of c fos , c jun , and junB is greatly enhanced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The increases were roughly proportional to those in ODC activity , suggesting that sialagogue dependent enzyme induction is regulated at the transcriptional level . ( 3 ) The mRNAs of four of nine proto oncogenes examined showed sialagogue dependent increases to maxima at 30 min ( c fos ) or 60 min ( c jun , c myc , and c src ) after the beginning of stimulation . ^^^ These increases were all transient , with the levels returning to the control values ( without sialagogue ) within 60 min . ( 4 ) The IPR dependent elevations of ODC activity and the mRNAs of ODC , c fos , and c jun were inhibited by monensin , but not by polymyxin B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional activation of c fos and c jun protooncogenes by serum growth factors in osteoblast like MC3T3 E 1 cells . ^^^ The present study was undertaken to clarify the relationship between c fos and c jun protooncogene expression and the differentiation and / or proliferation of osteoblasts , using osteoblast like MC3T3 E 1 ( E 1 ) cells . c fos mRNA was barely detectable , whereas c jun mRNA was constitutively expressed in E 1 cells after serum deprivation for 24 72 h . ^^^ When serum was added , a rapid and transient induction of c fos and c jun mRNAs was observed . ^^^ The c fos and c jun mRNAs reached peak levels at 30 minutes , with a rapid disappearance of c fos mRNA within 3 h and a much slower decrease in c jun mRNA . ^^^ The addition of serum together with cycloheximide , an inhibitor of protein synthesis , resulted in the superinduction of both c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both c fos and c jun were induced early after beta adrenergic stimulation , with peak mRNA levels preceding skeletal alpha actin induction by several hours . ^^^ Co transfection assays in cardiac myocytes and P 19 teratocarcinoma cells demonstrated that over expression of c jun , or c fos plus c jun , transactivated the skeletal alpha actin promoter by about 5 fold . ^^^ Skeletal alpha actin promoter sequences between 153 and 36 were required for maximal transactivation by c fos / c jun , and purified Fos and Jun were bound specifically within this region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the time course and distribution pattern of five cellular immediate early gene ( IEG ) encoded proteins after focal ischemia , the expression of c FOS , FOS B , c JUN , JUN B and JUN D was studied immunocytochemically in sham operated control animals and at different postischemic time intervals up to 24 h . ^^^ Individual IEG encoded proteins were sequentially induced with increased levels of immunoreactivity persisting for different time periods up to 24 h . c FOS , FOS B , c JUN and JUN B exhibited a characteristic distribution pattern as reflected by different staining intensities in individual cortical layers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and AP 1 activity in senescent human fibroblasts is not sufficient for DNA synthesis . ^^^ While ras injection was found to induce marked nuclear c fos expression and functional AP 1 transcription activity , this did not lead to DNA synthesis . ^^^ These results suggest that the senescence phenotype can not be solely attributed to the absence of c fos expression and that the proliferative block in these cells is either independent of AP 1 transcriptional activity , downstream of it , or involves multiple molecular mechanisms . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of Dex on the mRNA levels of the nuclear proto oncogenes c myc , c fos , and c jun was also investigated , since the oncoproteins ( Fos / Jun ) appear to play a role in the delayed glucocorticoid regulation of structural genes . ^^^ Interestingly , Dex increased the steady state levels of c myc , c fos , and c jun mRNAs in nonproliferating ( confluent ) hOB cells by 3 . 5 , 10 , and 2 . 0 fold , respectively , over control ( untreated cells ) values within one h of steroid treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Heterodimerization with c Fos is not required for cell transformation of chicken embryo fibroblasts by Jun . c Jun belongs to a family of proteins that require dimerization for activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ROS have also been shown to cause malignant transformation of normal cells , and to increase expression of certain proto oncogenes such as c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation by both EGF and PDGF requires the presence of factors that recognize the AP 1 binding site in the stromelysin promoter , but PDGF stimulation requires induction of the protooncogene c fos , while EGF acts through a FOS independent pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Parathyroid hormone induces c fos and c jun messenger RNA in rat osteoblastic cells . ^^^ Therefore , we examined the effects of PTH on c fos and c jun gene expression in a rat osteoblastic cell line ( UMR 106 01 ) . ^^^ Under control conditions , c fos and c jun mRNAs were present at low basal levels . ^^^ Nuclear run on assays demonstrated an increased rate of c fos and c jun transcription after PTH exposure . ^^^ To determine the signal transduction pathways involved , second messenger analogs were tested for their ability to mimic the effects of PTH . 8 Bromo cAMP and phorbol 12 myristate 13 acetate ( PMA ) caused increases in the abundance of c fos and c jun transcripts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is likely that the FOS and JUN proteins are among these factors and that they participate in the regulation of c fos expression by oxidants . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using Northern blot hybridization and nuclear run on analyses , we examined the modulation of c fos , fos B , fra 1 , c jun , and jun B gene transcripts in Rat 1 fibroblasts after ET treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have analysed the effect of mitogenic lectins on c Fos and c Jun protein levels as well as on activator protein 1 ( AP 1 ) binding and enhancer activity in Jurkat T cells . ^^^ Mitogen stimulation of T cells increases c Fos and c Jun protein levels , AP 1 binding and AP 1 transcriptional activity . ^^^ We conclude that stimulation with mitogenic lectins is sufficient to increase both c Fos and c Jun protein levels , AP 1 binding and AP 1 enhancer activity in Jurkat cells and that they act via mechanisms that could involve the activation of PKC . . ^^^ Both c Fos and c Jun protein levels were increased after Con A and PHA stimulation . ^^^ Since T cell stimulation increases both intracellular Ca2+ and cAMP levels and activates protein kinase C ( PKC ) , the possible involvement of these intracellular messengers in c Fos and c Jun induction was tested . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
FSH / IN not only stimulated DNA synthesis but also increased c myc , c fos , and c jun mRNA levels and the percentage of cells staining for c fos and c myc proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The decline in the basal c fos mRNA level in mid senescence should lead to an increase in Jun / Jun AP 1 homodimers at the expense of Fos / Jun heterodimers and may trigger a cascade of further changes in c myc , p 53 , and H ras expression in late passage senescent fibroblasts . . ^^^ Using quantitative RT PCR , we have monitored mRNA expression levels of c fos , c jun , JunB , c myc , p 53 , H ras , and histone H 4 during the replicative senescence of human fibroblasts . ^^^ The basal level of c fos mRNA decreased to one ninth that of the early passage levels , while junB declined to one third and c jun expression remained constant . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The rat Pi class form , GST P ( GST 7 7 ) , is strongly expressed not only in hepatic foci and hepatomas , but also in initiated cells that occur at the very early stages of chemical hepatocarcinogenesis , and is regarded as one of the most reliable markers for preneoplastic lesions in the rat liver . 12 O Tetradecanoylphorbol 13 acetate ( TPA ) responsive element like sequences have been identified in upstream regions of the GST P gene , and oncogene products c jun and c fos are suggested to activate the gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This may be caused by the lack of induction of genes from the jun family , whose gene products are necessary for dimerization with the c fos encoded protein , leading to an important step in growth factor signalling pathways ; stimulation of TPA responsive element ( TRE ) dependent transcriptional activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression and involvement of c fos and c jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines . ^^^ We have tested this hypothesis by analyzing c fos and c jun protooncogene expression and involvement in lymphoid cells deprived of growth factors . ^^^ Northern blot analysis shows that c fos and c jun protooncogenes are rapidly induced ( within 60 min ) after growth factor deprivation in IL 6 and IL 2 dependent mouse cells . ^^^ Antisense oligonucleotides directed against c fos and c jun mRNAs consistently reduced the expression of these genes in treated cells . ^^^ This reduction was associated with increased survival of growth factor deprived lymphoid cells , thus suggesting that the expression of c fos and c jun protooncogenes may represent an important early event in the activation of the genetic program of cell death . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Divergent regulation of the human atrial natriuretic peptide gene by c jun and c fos . ^^^ This same region was shown to interact with the c jun / c fos complex in an in vitro gel mobility shift assay . ^^^ These data imply that the ANP gene may be a physiological target for c fos and c jun dependent activity in the heart and suggest a potential mechanism linking environmental stimuli to its expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immediately after AoC , the levels of the ventricular expression of c fos and c jun protooncogenes were markedly lower in the old rats than in the adult animals . 5 d after the operation , the ratio of beta to alpha myosin heavy chain mRNAs increased significantly after AoC in both age groups . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One pathway may involve a protein tyrosine kinase of the src family , which leads to the induction of the c jun and c fos genes , among others . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further , both laminin and PA stimulated the DNA binding activity of c Fos and c Jun protein complex to the AP 1 site . ^^^ Laminin and PA 22 2 ( PA ) were also found to induce a rapid and transient mRNA expression of c fos and c jun protooncogenes in PC 12 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we demonstrate that two sets of genes , related to the entry of cells in the S phase , are induced by TSH : 1 ) immediate early genes , such as c jun and a gene coding for a zinc finger protein Xrox 20 / Egr2 , both having a pattern of expression similar to the c fos oncogene ; 2 ) early delayed genes such as ornithine decarboxylase ( ODC ) , 2F 1 , a gene that shows a strong similarity in aminoacid sequence to a mitochondrial ADP / ATP carrier , and the asparagine synthetase gene ( TS 11 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear proto oncogenes c fos and c jun are referred to as early response genes because the classical tumor promoter 12 O tetradecanoylphorbol 13 acetate ( TPA ) induces their expression to maximal levels within 2 h after treatment . ^^^ In mouse papilloma cell line 308 , OA induced higher and more sustained steady state levels of c jun and c fos than an equimolar dose of TPA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The rapid regulation of the nuclear proto oncogenes , e . g . , c myc , c fos , and c jun , are used as examples of these early regulatory genes in steroid regulated , receptor mediated gene transcription . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The increase in AP 1 binding activity was accompanied by the marked stimulation of the transcription of c fos but not that of c jun . ^^^ Blockade of the DNA binding complexes with an anti Fos mAb demonstrated a direct participation of c Fos in the AP 1 complexes induced by anti AIM mAb . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Indeed , in vitro , MAP kinase and / or RSK phosphorylates histone H 3 and the recombinant c Fos and c Jun polypeptides , transcription factors phosphorylated in a variety of cells in response to growth stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Growth hormone induces c fos and c jun expression in cells with varying requirements for differentiation . ^^^ An early event following the addition of GH to 3T3 F442A preadipocytes is induction of the expression of c fos and c jun . ^^^ Although c fos and c jun expression has been observed in conjunction with growth factor stimulated differentiation in several cell types , it is not clear whether protooncogene expression and differentiation are necessarily related . ^^^ However , GH ( 2 . 2 nM ) as well as calf serum induced the expression of c fos and c jun in 3T3 C 2 cells . ^^^ Thus , GH induced expression of c fos and c jun occurs in nondifferentiating cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Role of fos AP 1 binding sequence ( FAP ) in the induction of c fos expression by purified C kinase and in c fos down regulation following serum induction . ^^^ This C kinase induced expression of c fos was prevented by in vivo competition using co injection of oligonucleotides corresponding to the sequence of either the serum response element ( SRE ) or the fos AP 1 binding sequence ( FAP ) adjacent to SRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein kinase C independent activation of c jun and c fos transcription by epidermal growth factor . ^^^ Phorbol esters , epidermal growth factor ( EGF ) and serum induce the transient expression of the c jun and c fos proto oncogenes in quiescent fibroblasts . ^^^ We have investigated whether PKC and / or calcium play a role in mediating EGF stimulated c jun and c fos RNA and protein expression in quiescent NIH 3T3 fibroblasts . ^^^ PMA , EGF or serum stimulated a rapid , transient increase in c jun and c fos expression and cJun protein synthesis in quiescent NIH 3T3 cells . ^^^ Depletion of whole cell PKC activity by pretreatment with PMA abolished any subsequent response to PMA , but had no effect on the ability of EGF or serum to induce c jun and c fos RNA and cJun protein expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study we have found that both c jun and jun B , partners of c fos in heterodimeric transactivating complexes , are equivalently expressed in young and senescent cells at both early ( 1 6 hr ) and late ( 12 or 16 hr ) time points following serum stimulation of quiescent cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both elements bind factors different in modification or / and constitution from AP 1 , the heterodimeric transcription factor composed of c Fos and c Jun that controls the activity of the UV and phorbol ester response element ( 72 TGAGTCA 66 ) of the human collagenase gene . . ^^^ In the same cells UV and phorbol esters only marginally enhance the abundance of RNA transcribed from the jun D gene and from the gene coding for the serum response factor ( which in turn acts on the UV and phorbol ester response element of the c fos gene ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present studies investigate the effects of in vivo ionizing radiation , with subsequent stimulation of beta adrenergic receptors by isoproterenol , on parotid gland function and on the expression of the early response genes , c fos , c jun , and jun B . ^^^ Irradiation alone increased the expression of c fos , c jun , and jun B . ^^^ Isoproterenol alone induced high levels of c fos and jun B mRNA but not of c jun mRNA . ^^^ These observations suggest that the expression of the proto oncogenes c fos , c jun , and jun B is probably regulated through differential signal transduction pathways which may be activated by these external stimuli and may be associated with functional changes induced in the rat parotid gland by ionizing radiation and by ionizing radiation and isoproterenol . . ^^^ The combination of irradiation and isoproterenol had an additional effect on the levels of c fos and jun B mRNAs and proteins particularly at earlier experimental times ( 1 to 8 h ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Additionally , the induction of c fos , c jun , and 3 hydroxy 3 methylglutaryl coenzyme A reductase transcription was inhibited by manidipine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We confirmed other reports that transformed p21RAS expressing cells constitutively express the transcription factor complex jun / AP 1 , in this case resulting from the ongoing expression of the c jun and c fos genes in the absence of IL 3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Administration of kainate or pentylenetetrazole increased c fos , c jun , junB , and junD mRNA levels in rat brain in a dose dependent manner . ^^^ Adrenalectomy significantly potentiated kainate induced increases , compared with increases caused by kainate ( 4 mg / kg ) alone , in the hippocampal mRNA levels of c fos and junB by 6 . 5 fold and of junD by twofold and tended to augment c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cellular oncogenes such as c fos , c jun and c myc are expressed prior to estrogen induced growth of normal target tissues such as rodent uterus . ^^^ After 7 months of estrogen treatment , kidney tumors also contained elevated amounts of c fos , c jun and c myc transcripts at levels comparable with older tumors . ^^^ Ratios of c fos , c myc and c jun in estrogen treated ( 5 months ) over control tissue were 1 . 4 , 1 . 1 and 1 . 3 respectively . ^^^ Overexpression of cellular oncogenes such as c fos , c jun and c myc may have played a role in the induction and growth of kidney tumors by estradiol in hamsters . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This fusion product has a dominant negative effect on the transcriptional activation elicited by phorbol esters , c Jun , c Fos , Ras and E1A on an AP 1 responsive site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Coexpression of chicken c Fos increased formation of transformed foci by Jun proteins of moderate to low oncogenic potency but had no effect on highly transforming Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The serum response element and an AP 1 / ATF sequence immediately downstream co operate in the regulation of c fos transcription . ^^^ A consensus AP 1 DNA binding site can substitute for the AP 1 / ATF like sequence present in the c fos promoter to activate transcription in an additive fashion with the SRE in growing cells , and co operate in repression in quiescent cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both HD lines also constitutively expressed transcripts for c fos and c jun , which are involved in heterodimeric formation of the transcription factor activation protein 1 , as well as for the NF kappa B / KBF1 gene . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
No messenger RNA was detected for myeloperoxidase , c myc and c jun , while c fms , c fos and c myb were expressed on Northern blotting . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunocytochemistry with specific antisera was used to assess regional levels of six immediate early gene encoded proteins ( KROX 24 , c FOS , FOS B , c JUN , JUN B and JUN D ) in the rat hippocampus after 15 min of bicuculline induced seizures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dioxin induces expression of c fos and c jun proto oncogenes and a large increase in transcription factor AP 1 . ^^^ These changes are then followed by induction of the immediate early proto oncogenes c fos , jun B , c jun , and jun D , and by large increases in AP 1 transcription factor activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
High c myc mRNA expression was detected on acinar epithelial cells . c myc did not correlate with c fos and c jun protein expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that the promoter is inducible by serum and expression of c Fos and c Jun , and it is positively auto regulated by its gene product . ^^^ A 50 base pair sequence is sufficient to confer c Fos + c Jun and c Ets 1 responsiveness to a heterologous promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After phorbol ester and interferon treatment a stronger expression of the protooncogene c jun was detectable in the hPKC alpha overexpressing cells , whereas expression of c fos and c myc was not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The inhibitors of ADP ribose transferase benzamide and 3 amino benzamide suppressed the elongation of the c fos message and the de novo synthesis of nuclear factors , among them c Fos and c Jun , which bind to the fos AP 1 motif in vitro only following stimulation with active oxygen . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis and nuclear run off transcription assays were used to assess the activation of c fos , c jun , TIS 1 , TIS 8 , and TIS 11 after exposure of PC 12 cells to NGF in the presence or absence of 2 AP and 6 TG . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein synthesis inhibitors differentially superinduce c fos and c jun by three distinct mechanisms : lack of evidence for labile repressors . ^^^ Protein synthesis inhibitors strongly augment and prolong the usually transient induction of c fos and c jun by growth factors , phorbol esters etc . , a phenomenon termed superinduction which is conventionally regarded as a secondary consequence of translational arrest . ^^^ First , we show that labile repressors , widely postulated to act negatively on diverse superinducible genes , are not involved in regulating c fos and c jun . ^^^ Secondly , two components of c fos and c jun superinduction , namely the delay in shutting off transcription and stabilization of their mRNAs , arise from translational arrest and are common to all protein synthesis inhibitors . ^^^ Thirdly , the recently described capacity to act positively as nuclear signalling agonists to stimulate pp33 / pp15 phosphorylation is restricted to compounds such as anisomycin and cycloheximide ; these , but not emetine or puromycin , will induce c fos / c jun on their own . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because previous results have suggested that c fos and c jun protooncogenes are expressed in human leukemic cell lines induced to undergo megakaryocytic differentiation , we have analyzed the expression of these two protooncogenes in normal MK . ^^^ Studies were performed , by in situ hybridization and immunofluorescence , on human MK obtained either directly from bone marrow or from culture of MK progenitors . c fos and c jun transcripts were detected in most cultured or fresh marrow MK from adult donors . ^^^ Expression was much higher in cytologically immature than in mature MK whereas no expression was detected in the most mature MK . c fos and c jun expression increased dramatically with MK size . ^^^ In conclusion , our results suggest that c jun and c fos may play a role in the transduction of signals by several growth factors during terminal MK differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , AP 1 binding activity in the NAc of animals treated chronically with cocaine remained elevated at acute levels 18 hr after the last chronic injection , a time at which c fos and c jun mRNA levels and Fos like immunoreactivity had returned to control values . ^^^ We therefore examined changes in the mRNA levels for the IEGs c fos , c jun , fosB , junB , and zif 268 in the NAc of rats treated acutely and chronically with cocaine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Normal and osteoarthritic ( OA ) human articular cartilage chondrocytes , released enzymatically in the presence of 0 . 5 % fetal calf serum , display constitutive expression of early response activating protein ( AP 1 ) genes ; c fos , c jun and jun B . ^^^ Expression of c fos , c jun , jun B , metallothionein and metalloproteinase genes in human chondrocyte . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , immunoprecipitation with specific antisera showed that de novo synthesis of Jun B and c Jun proteins , accompanied by c Fos , was stimulated after cross linking of sIgR on BAL 17 B cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using the phorbol ester 12 O tetradecanoyl phorbol 13 acetate ( TPA ) and calcium , two agents known to induce keratinocyte differentiation in vitro , we examined the expression of the genes encoding c fos , c myc , and c jun ; involucrin , a protein precursor of the keratinocyte cornified envelope ; and L 7 , a ribosomal protein . ^^^ Our studies showed a constant low level of c fos and c jun expression in unstimulated cells with no significant change after addition of either TPA or calcium except when transcript breakdown was inhibited by cycloheximide . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All cellular signals characterized so far are reverted during retrodifferentiation : Redistribution of PKC and down regulation of c fos and c jun contribute to an interruption of the differentiation associated transsignaling cascade . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Possible involvement of proto oncogenes c jun and c fos . ^^^ Using endothelial cells from human umbilical vein ( HUVECs ) and human aorta ( HAECs ) , we have studied this regulation of t PA and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , at the mRNA level and have compared their induction with the expression of platelet derived growth factors A and B ( PDGF A and PDGF B ) and the proto oncogenes c jun and c fos . ^^^ The induction of t PA mRNA by PMA was dependent on protein synthesis and was preceded by a strong transient increase in c jun and c fos mRNA levels ; the induction of c fos but not of c jun was potentiated by forskolin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the IMR 90 and MG 63 cells , EGF stimulated the transcription of the c fos and c jun genes encoding the transcriptional factors which interact directly with the promoter region of the human collagenase gene . ^^^ Recombinant interleukin 1 beta ( rIL 1 beta ) induced collagenase and c jun but not c fos mRNA in the MG 63 cell . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
T antigens ' role in polyomavirus transformation : c myc but not c fos or c jun expression is a target for middle T . ^^^ JE , c fos , c jun and c myc are ' immediate early ' genes induced in response to PDGF . ^^^ Characterization of these cell lines revealed that : ( a ) MT but not LT causes morphological transformation , ability to grow in agarose suspension ; ( b ) cooperation between LT and MT is evident in vitro , however , high and simultaneous LT and MT expression does not warrant tumorigenic potential ; ( c ) MT expression does not correlate with tumorigenic potential but alters the probability of eliciting tumors ; ( d ) JE and c myc ( but not c fos or c jun ) are constitutively expressed in MT transfectants . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The first peak involves c jun and oct 1 expression in neurons , and the second involves c jun , c fos , and oct 1 expression in neurons and nonneuronal cells . ^^^ Corneal infection without prior scarification induced c jun , c fos , and oct 1 expression in some neuronal and nonneuronal cells of the trigeminal ganglia 2 to 9 days p . i . ^^^ Independently of the presence of latent HSV 1 in explanted ganglia , expression of c fos , c jun , and oct 1 was induced first in nonneuronal cells , peaking 6 to 10 h postexplantation , and then in neuronal cells , with a peak at 24 h after explantation when expression of viral replicative genes was first detectable . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of c fos , c jun , jun B , and c myc messenger ribonucleic acids by gonadotropin and growth factors in cultured pig Leydig cell . ^^^ To evaluate the possibility that protooncogenes mediate long term effects of these factors , their action on the levels of c fos , c jun , jun B , and c myc messenger ( m ) RNAs was studied . hCG ( 10 ( 9 ) M ) produced a time dependent increase in c fos ( 9 fold ) , jun B ( 18 fold ) and c myc ( 5 fold ) mRNA levels but did not affect c jun . ^^^ Moreover , EGF and bFGF potentiated the effects of hCG on c fos and jun B , whereas hCG potentiated the action of growth factors on c jun . ^^^ At optimal concentrations , the effects of EGF and bFGF on c fos and jun B mRNAs were lower than those induced by hCG , but their effects on c myc mRNA were higher . ^^^ Transforming growth factor beta increased only jun B mRNA , whereas insulin like growth factor 1 increased c fos , jun B , and c myc but less effectively than hCG . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Phe 706 mutant receptor was most strongly affected in its ability to increase growth rate or elevate the levels of c fos and NGF1A mRNAs , whereas the Gly 706 mutant receptor was most markedly affected in its ability to induce a change in cell morphology or increase the levels of c jun and NGF1A mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The degree of c fos and c jun stimulation by TNF alpha or EGF did not correlate with the levels of collagenase and stromelysin message stimulated by these factors . ^^^ EGF stimulated significant accumulation of both c fos and c jun mRNAs while only very low amounts of these messages were stimulated by TNF alpha . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To begin to investigate changes in gene expression that occur during kindling , we used in situ hybridization histochemistry to examine the time course of expression of mRNAs of the immediate early genes ( IEGs ) c fos , c jun , NGFI A , and c myc within the dorsal hippocampus of rats following a kindling AD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun B , c jun , jun D and c fos mRNAs in nucleus caudalis neurons : rapid selective enhancement by afferent stimulation . ^^^ Jun B , c jun , jun D and c fos mRNAs in nucleus caudalis neurons : rapid selective enhancement by afferent stimulation . ^^^ In situ hybridization using cDNAs complementary to specific regions of the mRNAs encoding 3 members of the jun transcription factor gene family and c fos reveals modest levels of hybridization over superficial laminae of the nucleus caudalis of the spinal tract of the trigeminal in sections taken from unstimulated brains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An analysis of defined elements in different promoters suggests that serine / threonine phosphoprotein phosphatases are involved in the regulation of the c jun and the collagenase 12 O tetradecanoyl phorbol 13 acetate ( TPA ) response element ( TRE ) as well as the c fos serum response element ( SRE ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These include 1 ) transient inositol 1 , 4 , 5 trisphosphate ( IP 3 ) formation and Ca2+ mobilization , 2 ) increased out put of arachidonic acid and prostaglandin E 2 ( PGE 2 ) , 3 ) enhanced cyclic AMP ( cAMP ) generation , 4 ) increased de novo DNA synthesis , and 5 ) an induction of the `` immediate early ' ' genes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Selective induction of c jun and jun B but not c fos or c myc during mitogenesis in SV 40 transformed cells at the predifferentiation growth arrest state . ^^^ Whereas insulin and vanadate had no effect on the expression of c fos , c myc , c jun , jun B , or ornithine decarboxylase activity in nontransformed 3T3 T cells , insulin and vanadate showed different effects on the expression of these genes in CSV 3 1 cells . ^^^ Insulin induced a rapid and transient accumulation of c fos mRNA followed by induction of c myc , c jun , jun B , and ornithine decarboxylase . ^^^ In contrast , vanadate induced the expression of c jun , jun B , and ornithine decarboxylase without inducing c fos and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proto oncogene expression in C 8161 cells was compared with A375P and A375M variants using Northern blot analysis . c myc expression was 6 fold greater than both A 375 variants ; c fos expression was 3 . 4 fold less than A375P and 1 . 7 fold less than A375M ; c jun in C 8161 cells was 2 . 5 fold and 2 . 1 fold greater than expression in A375P and A375M , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Characteristics of c fos and jun B gene expression in A 5 cells after beta adrenoreceptor stimulation and during the cell cycle . ^^^ The beta adrenoreceptor agonist isoproterenol elevates cAMP concentrations in the A 5 rat salivary epithelial cell line and rapidly and transiently induces the expression of c fos and jun B at 30 and 60 min following continuous stimulation of these cells . ^^^ We show here that the inducibility of these genes by isoproterenol or 8 BrcAMP is transcriptionally regulated and short ( 5 min ) incubations of A 5 cells with either agent is sufficient to trigger the induction of c fos and jun B . ^^^ Both c fos and jun B mRNA are elevated at the early phase of the cell cycle and are detectable throughout the cycle . ^^^ These studies provide the first evidence for the transcriptional regulation of c fos and jun B by beta adrenergic receptor stimulation or cAMP in an epithelial cell line ( A 5 ) and demonstrate the coordinate expression and inducibility of these genes at the different stages of the A 5 cell cycle . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In agreement with the presence of c fos and c jun recognition sites on the transin gene , expression of these oncogenes preceded transin expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the c myc , c fos , c jun , c erbB , and c Ha ras protooncogenes was compared by Northern blot analysis of total RNA extracted from keratome biopsies of normal skin and psoriatic plaques . ^^^ C myc , c jun , c erbB , c fos , and c Ha ras transcript levels were not significantly increased in lesional psoriatic epidermis when protooncogene mRNA levels were normalized to those of the cyclophilin or lipocortin genes . ^^^ C myc , c fos , and c jun transcripts were significantly induced over in vivo levels 2 4 h after organ culture of normal or psoriatic keratome biopsies , demonstrating that these genes can be highly expressed in the context of tissue injury . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A rapid increase in the RNA levels of the proto oncogenes c fos , c jun , and c myc was detected after human cytomegalovirus infection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
HBGF 1 also increases c fos , c jun , and c myc mRNA levels ; in the presence of cycloheximide , PDGF A chain and protooncogene mRNA accumulation kinetics are similar . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The steady state levels of RNA of c fos , c myc , and c jun were detected at 0 to 1 and 12 to 30 h after infection but not at 6 h postinfection . ^^^ Half lives of c fos , c myc , and c jun were similarly short at both early and late times after infection , as determined by dactinomycin chase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A panel of epitope specific antibodies , directed against c Fos , c Jun , and FosB derived oligopeptide sequences , was generated and used to study the interaction of Fos and Jun proteins and the binding of the Fos / Jun complex to the AP 1 binding site ( TRE ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of nine proto oncogenes ( c myc , N myc , c fos , c jun , p 53 , H ras , N ras , c raf , hst ) and other three genes ( AFP , PCNA , GST P ) were investigated during spontaneous development to hepatocellular carcinomas ( HCCs ) in LEC rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Site specific mutagenesis of a putative AP 1 site within the intron abolishes trans activation by c fos in F 9 cells . ^^^ These results identify an enhancer within the first intron of K 18 that may interact directly with c jun and c fos via a conserved AP 1 binding site . ^^^ Activation of an intron enhancer within the keratin 18 gene by expression of c fos and c jun in undifferentiated F 9 embryonal carcinoma cells . ^^^ Cotransfection with c jun or c fos expression vectors had little effect on the expression of the K 18 reporter construct in a parietal endodermal cell line already expressing the endogenous mouse gene . ^^^ K 18 expression in undifferentiated F 9 cells may be limited by the low levels of c jun and c fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Alpha and beta adrenergic stimulation of neonatal rat myocardial cells both produce an increase in the assembly of an individual contractile protein ( myosin light chain 2 ) into organized sarcomeric units and also rapidly induce mRNAs for the immediate early genes c fos and c jun , thereby suggesting a potential role for these protooncogenes in sarcomerogenesis . alpha Adrenergic stimulation results in the co induction of mRNAs encoding a zinc finger protein gene ( Egr 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Functionally , Djun in cooperation with mouse c fos can trans activate activator protein 1 DNA binding site when introduced into mammalian cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of cadmium on the expression of oncogenes c jun , c fos , and c myc was studied by exposing L6J1 myoblast cultures to different doses of cadmium chloride and then analyzing the abundance of oncogene transcripts . ^^^ Both the c fos and c jun genes could . ^^^ Induction of c myc and c jun by cadmium and c fos by a combination of cadmium and cycloheximide could be abolished by blocking transcription with actinomycin D . ^^^ The cadmium induced increase in c jun and c myc mRNA was enhanced in myoblasts stably transfected with a mouse c fos gene under a metallothionein promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This cDNA clone was isolated by expression cDNA cloning , and encodes the human c Jun protein , which together with c Fos forms the heterodimeric activator protein 1 transcription complex . ^^^ Whereas c Fos / c Jun heterodimers do not exist in B cells , they form and bind to the X 2 box in class 2 nonexpressing cells . ^^^ Thus , c Fos / c Jun heterodimers might contribute to the repression of DRA gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased transcription of the glucose transporter ( GLUT 1 ) gene , as well as several immediate early genes ( c fos , c jun , jun B , and beta actin ) was observed within 15 min of exposure to TNF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the LC and some other brain regions , induction of c fos during opiate withdrawal was associated with a parallel induction of c jun , another nuclear proto oncogene , which , like c fos , is expressed rapidly in brain in response to certain extracellular stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A large transient increase in the expression of the c fos gene was obtained rapidly , 30 min after addition of serum and a similar increase in c jun expression after one hour . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis showed that the immediate early mRNAs normally induced shortly after growth factor stimulation in quiescent fibroblasts ( c fos , c jun , Egr 1 , c myc , JE , and KC ) , and other growth related genes ( 2F1 , c Ha ras , and p 53 ) , are either not induced or remain unchanged during G 1 to S phase progression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of 13 protooncogenes and immediate early genes was compared with 4 `` control ' ' genes after the addition of either IL 3 or phorbol myristate acetate ( PMA ) to IL 3 deprived cells . mRNA transcripts encoding c myc and the T cell receptor c gamma gene were induced to high levels only after IL 3 addition , whereas c fos , fos B , c jun , jun B , Krox 20 , and Krox 24 were induced transiently only after PMA addition . ^^^ When cells were serum and IL 3 deprived , c fos , fos B , c jun , jun B , Krox 20 , and Krox 24 were detected after exposure to either serum or PMA . ^^^ Although c fos , fos B , c jun , jun B , Krox 20 , and Krox 24 expression can be detected in IL 3 dependent cells after exposure to either PMA or serum , these genes were not detected after IL 3 addition , which allows cell cycle progression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , phospholipase C ( PLC ) hyperresponsiveness can be seen only under angiotensin stimulation , as are the expressions of c jun , c fos , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The relative stimulation of zif 268 mRNA by RA was much larger than that of other early genes , including c fos , c jun , and junB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This AP 1 like element , when cloned into the tk promoter , responds to the AP 1 activity of c jun / c fos products in both CV 1 and F 9 cells . ^^^ A 23 base pair DNA element containing the overlapping glucocorticoid responsive element and AP 1 sites can be positively regulated by glucocorticoid receptor in the absence of c jun / c fos products . ^^^ AFP promoter activity induced by c jun / c fos can be repressed by cotransfected glucocorticoid receptor . ^^^ When plasmids expressing glucocorticoid receptor , c jun and c fos are cotransfected together , they repress each other . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protooncogene c fos has been implicated in the control of proliferation and transformation of fibroblasts , and its protein product is an essential component of transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Patients with IgA nephropathy expressed more c myc , c raf , c fos , and c jun proto oncogene RNA than did normal controls . ^^^ When the amount of urinary protein excretion was used as an indicator of disease activity ( greater than 1 g / day ) , a positive correlation was found between c myc , c raf , c fos , and c jun expression and urinary protein excretion ( P less than 0 . 01 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c jun , jun B , and c fos proto oncogenes in human primary melanocytes and metastatic melanomas . ^^^ Analysis of the regulation of c jun , jun B , and c fos RNA transcript expression was performed in human primary melanocytes and metastatic melanoma cell strains . ^^^ In primary melanocytes , the expression of c jun , jun B , and c fos RNA transcripts was dependent on the growth promoting agents present in the medium . ^^^ Uniformly high c jun , jun B , and c fos RNA transcript levels were observed in melanocytes cultivated in complete medium . ^^^ Higher levels of c jun RNA transcripts and low levels of c fos RNA transcripts were observed in melanocytes cultivated in plain medium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A number of primary and clonal tumour derived cell lines were established which expressed high levels of c fos , c jun as well as the cartilage specific gene type 2 collagen and which gave rise to cartilage tumours in vivo , some of which also contained bone . ^^^ Interestingly , the levels of c Fos and c Jun appeared to be coordinately regulated in the cell lines as well as in chimeric tissues . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of c fos and c jun protooncogene expression by the Ca ( 2+ ) ATPase inhibitor thapsigargin . ^^^ Here we show that treatment of mouse NIH 3T3 fibroblasts with thapsigargin induced rapid expression of the c fos and c jun protooncogenes . ^^^ Inhibition or depletion of protein kinase C partially diminished the c fos but not the c jun response . ^^^ Furthermore , thapsigargin could synergize with the tumor promoter phorbol 12 myristate 13 acetate to induce c fos but not c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Elevated levels of c jun and c fos transcripts in the aged rat liver . ^^^ Northern hybridization showed marked increases of c jun , c fos , and glutathione S transferase P ( GST P ) in 24 month old rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have used primary cortical cultures to study the regulation of four of these genes , c fos , c jun , jun B , and zif 268 . ^^^ Immunocytochemical studies with antibodies to Jun B , c Jun , and c Fos demonstrate intense staining in the nuclei of a subset of cortical neurons in mature cultures ( 21 25 days in vitro ) but not young cultures ( 3 7 days in vitro ) . ^^^ Tetrodotoxin or N methyl D aspartate receptor antagonists suppress basal immunoreactivity to Jun B and c Fos , but not c Jun , indicating that the basal level of c Jun expression is not dependent on electrical activity . ^^^ Picrotoxin , an agent that increases synaptic excitation indirectly by blocking inhibitory synaptic currents mediated by gamma aminobutyric acidA receptors , markedly increases the percentage of neurons displaying immunoreactivity to c Fos , c Jun , Jun B , and Zif 268 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We now find that this EpRE is composed of two adjacent 9 base pair motifs related in sequence to the AP 1 binding site , a transcriptional enhancer originally identified as the phorbol 12 myristate 13 acetate ( PMA ) response element and known to be regulated by the binding of protein products of c jun and c fos genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Correlation of c fos / c jun expression with histiocytic differentiation in Hodgkin ' s Reed Sternberg cells . ^^^ The c fos proto oncogene , which is the normal homolog of the transforming gene carried by murine osteogenic sarcoma viruses , interacts with the protein product of another proto oncogene , c jun , to form a heterodimer that can recognize and bind to a specific sequence of nucleotides in the DNA . ^^^ The expression of c fos and c jun is linked to the proliferation of certain cells and the differentiation of others , including those of monomyelocyte lineage . ^^^ The authors used two cultured Hodgkin ' s Reed Sternberg ( H RS ) cell lines , KM H 2 and HDLM 1 , and their single cell clones to study the correlation of c fos / c jun expression with cell differentiation in H RS cells . ^^^ Within 48 hours after induction with phorbol ester ( TPA ) , both parent lines exhibited markedly increased expression of c fos / c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun mRNA in the developing chicken lens : relationship to cell proliferation , quiescence , and differentiation . ^^^ The in vivo developmental pattern of c fos and c jun mRNA expression has been examined in the embryonic chicken lens using a coupled reverse transcription / polymerase chain reaction assay . ^^^ The results showed that c fos and c jun mRNAs accumulated during development of the embryonic chicken lens epithelium as the proportion of proliferating cells decreased , suggesting that quiescent epithelial cells express high levels of both protooncogene mRNAs . ^^^ Cells in the early stages of terminal differentiation near the lens equator also contained relatively high levels of c fos and c jun mRNA . ^^^ As lens fiber cells matured , the number of copies of c fos mRNA per cell decreased markedly , while c jun mRNA increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of a 5 ' IL 2 chloramphenicol acetyltransferase plasmid with c Fos and / or c Jun enhances the induction of IL 2 chloramphenicol acetyltransferase activity , confirming that the IL 2 promoter contains a functional AP 1 site . ^^^ Both AP 1 sites may be targets for c Fos action , as inferred from the results of experiments in which c Fos was cotransfected with internal deletion mutants of the IL 2 promoter lacking either AP 1 site . ^^^ Northern analysis indicates that mRNAs for at least six members of the Fos / Jun family ( c fos , fosB , fra 1 , c jun , junB , and junD ) are expressed in activated Ar 5 cells ; thus the AP 1 sites of the IL 2 promoter may bind different dimeric Fos / Jun complexes at different times after T cell activation , perhaps mediating both positive and negative regulation of the IL 2 promoter . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun , the protein products of the nuclear proto oncogenes c fos and c jun , associate preferentially to form a heterodimer that binds to DNA and modulates transcription of a wide variety of genes in response to mitogenic stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Role of [ Ca2+ ] 1 in induction of c fos , c jun , and c myc mRNA in rat PTE after oxidative stress . ^^^ In this study , we investigated the expression of the proto oncogenes c fos , c myc , and c jun , which play a key role in proliferation and differentiation , using primary cultures of rat proximal tubular epithelium exposed to oxidative stress generated by the xanthine / xanthine oxidase system . ^^^ This system generates superoxide and H2O2 in the extracellular space stimulating the release of active oxygen species from inflammatory cells . c fos mRNA was expressed within 15 min , peaked at 30 min , and returned to constitutive levels by 3 h . c jun mRNA began to rise after 30 min , peaked at 120 min , and remained above the constitutive levels up to 180 min . c myc mRNA expression was less affected by the treatment , with levels increasing gradually over the 180 min period . ^^^ Our results show that oxidative stress provokes sequential expression of c fos , c jun , and c myc , mRNA in this order . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , cotransfections with c fos and c jun expression plasmids markedly enhance induction of the IL 2 promoter in minimally stimulated T cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several consensus sequences have been identified , including an SRE and AP 1 binding site whose relative positions are identical to those in the 5 ' upstream region of the c fos gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because c Jun is the most potent transactivator in the AP 1 complex and is elevated in Ha ras transformed cells , in which c Fos is downregulated , we focused on it as a potential target . c Jun could convert input from an oncogenic signalling cascade into changes in gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We present the first comparative investigation of the basal and transsynaptically induced expression of c JUN , JUN B , JUN D , c FOS , FOS B , and KROX 24 proteins in the spinal cord , using immunocytochemistry with specific antibodies . ^^^ In motoneurons of the ipsilateral ventral horn , c JUN , JUN D , and c FOS appeared after 8 hours . ^^^ Immunoreactivity decreased to basal levels between 8 and 16 hours . c FOS and JUN D were expressed in both the superficial and deep dorsal horn ; in the latter , c FOS and JUN D persisted longer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
P and P+ cells exhibited induction of c jun and c fos messenger RNA levels by phorbol ester , but P cells had significantly lower basal and induced levels of jun mRNA than P+ cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of PKC has been implicated in the regulation of certain immediate early response genes , and in the present studies , TPA rapidly induced c fos and c jun gene expression . ^^^ Levels of c fos and c jun transcripts remained elevated during periods of PKC activation and also returned to levels observed in control cells by 30 36 days , when the cells entered retrodifferentiation . ^^^ Staurosporine , a nonspecific inhibitor of PKC , partially blocked TPA induced adherence and growth inhibition and concomitantly prevented TPA induced c fos and c jun gene expression . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In situ hybridization analysis of c fos and c jun expression in the rat brain following transient forebrain ischemia . ^^^ Early induction of the mRNAs encoding the c Fos and c Jun nuclear proteins was examined in rat brain by in situ hybridization at various timepoints following global forebrain ischemia by the method of four vessel occlusion . ^^^ In the cerebellum , a similar temporal pattern was observed : the granule cells exhibited a prompt but patchy expression of c fos and c jun that was followed by a delayed signal in the Purkinje cells . ^^^ Without exception c fos and c jun appeared to be expressed in unison , although the time course of c fos and c jun mRNA accumulation and decay was different in various brain regions : invariably the cerebellum returned rapidly to its baseline with virtually no remaining signal at 3 h postischemia , while c fos and c jun activation in the hippocampus remained high at 3 h and returned to baseline by 6 h . ^^^ Several other brain regions showed early production of c fos and c jun mRNAs , such as the medial habenula , piriform cortex , the amygdala , the centromedian , lateral posterior , paracentral , intermediodorsal and reuniens nuclei of the thalamus and the ventromedial and dorsal nuclei of the hypothalamus ; in the brainstem , the trapezoid body and the noradrenergic neurons of the locus ceruleus as well as the adrenergic neurons in the ventrolateral medulla ( C 1 group ) and nucleus tractus solitarius ( C 2 group ) regions displayed slightly less intense hybridization signals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The variant 308 10 Gy 5 cells unlike the parental cells also show by northern analysis high steady state levels of the following gene transcripts : stromelysin , metallothionein 2 A and the proto oncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear extract from the Morris hepatoma that did not have the Mr 47 , 000 CRE binding factor contained proteins immunologically related to the CREB , c Jun , and c Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We observe that the expression of endogenous c jun and jun B genes is induced by E1A , which directly transactivates the promoters of c fos , c jun , and jun B . ^^^ Coexpression of c fos and E1A 12S , however , blocks the transactivation by c jun , suggesting an important role for fos in determining the dominance of the 12S or 13S protein . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have compared the binding properties of c JUN , JUN B , and JUN D in the absence or in the presence of c FOS , FOS B , and FRA 1 to different AP 1 and CRE containing oligonucleotides . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ang 2 ( 10 ( 9 ) 10 ( 8 ) M ) and a protein kinase C activator , phorbol 12 myristate 13 acetate ( PMA , 10 ( 8 ) M ) rapidly induced c fos as well as c Jun and Jun B mRNA expression in RASM cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
E1A was also shown to alter the expression of mRNAs for the early response genes c fos , c myc , egr 1 , and c jun and their regulation in response to NGF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of smooth muscle alpha actin was delayed and sustained after aortic constriction , whereas the nuclear oncogenes c jun and junB were expressed rapidly and transiently , providing potential dimerization partners for transcriptional control by c fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Localization and regulation of c fos and c jun protooncogene induction by systolic wall stress in normal and hypertrophied rat hearts . ^^^ The effect of changes in left ventricular ( LV ) systolic force generation on cardiac c fos and c jun protooncogene expression was studied by using isolated beating hearts from male Wistar rats . ^^^ Using Northern and slot blot analyses , we found that LV tissue from control hearts that generated high levels of LV systolic wall stress expressed 3 to 4 . 4 fold higher c fos and c jun mRNA levels in comparison with tissue from the respective flaccid right ventricles , and in comparison with LV tissue from hearts that generated minimal LV systolic wall stress . ^^^ When c fos and c jun mRNA expression was compared in hearts with chronic LV hypertrophy due to ascending aortic banding and age matched control hearts that generated similar incremental levels of LV systolic wall stress , significantly lower levels of c fos and c jun mRNA were measured in the hypertrophied hearts . ^^^ These data suggest that , in this isolated isovolumic beating heart preparation , the active generation of an acute increment in LV systolic force independent of passive diastolic myocardial stretch causes a rapid induction of both c fos and c jun , which is down regulated in the presence of established LV hypertrophy . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mechanisms responsible for the human cytomegalovirus ( HCMV ) induced increase in cellular oncogene RNAs for c jun , c fos , and c myc in human embryo lung cells ( 1 . ^^^ The maximum rates of transcription for c jun and c fos genes occurred at 40 min postinfection , while for the c myc gene the maximum rate occurred at about 60 min . ^^^ The half life for c fos or c jun was about 20 min , and that for c myc was about 40 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Polyomavirus ( Py ) DNA replication is regulated by its enhancer , which contains an AP 1 site , c Jun and c Fos , the products of nuclear protooncogenes c jun and c fos , form the heterodimeric transcriptional activating factor AP 1 . ^^^ Overexpression of c fos and c jun genes strongly stimulated Py DNA replication from the Py origin of replication as well as transcription from the Py early promoter through the AP 1 binding site . ^^^ The nuclear protooncogenes c jun and c fos as regulators of DNA replication . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos mRNA and AP 1 DNA binding activity by cAMP in cooperation with either the adenovirus 243 or the adenovirus 289 amino acid E1A protein . ^^^ Significant E1A dependent induction of c fos mRNA and AP 1 binding activity was observed in cells expressing either E1A protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Okadaic acid treatment was found to dramatically increase mRNA transcripts of the jun family of proto oncogenes including c jun , junD , and junB and to a lesser extent the fos family including c fos and fra 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , the classical immediate early genes c myc , c fos and c jun were essentially uninducible upon activation of a ts 5 src mutant in rat 1 fibroblasts ( Welham et al . , 1990 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Sequential and transient expression of c fos , c jun , c myc , c Ha ras and c Ki ras proto oncogene RNA transcripts with zonal heterogeneity was demonstrated in virtually all hepatocytes of adult rat liver by in situ hybridization with single stranded , [ 35S ] labeled cRNA probes at various time points after intraperitoneal administration of a single dose of carbon tetrachloride ( CCl 4 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have shown that TNF rapidly induces the proto oncogenes c fos and c jun in the adipogenic TA 1 cell line and have used these responses to characterize the intracellular mediators of TNF action . ^^^ We find that arachidonic acid , which is released in response to TNF , induces c fos , but not c jun mRNA in quiescent TA 1 cells . ^^^ Pretreatment of the cells with lipoxygenase inhibitors abolishes the induction of c fos by TNF , while the induction of c jun is unaffected ; in contrast , a cyclooxygenase inhibitor has no effect on either response . ^^^ Finally , we have demonstrated that TNF stimulates production of lipoxygenase metabolites in TA 1 cells and that one of these , 5 HPETE , induces c fos , but not c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We describe here an unusual member of the Fos family that is also induced , namely , a truncated form of FosB ( delta FosB ) missing the C terminal 101 amino acids of FosB . delta FosB retains the dimerization and DNA binding activities of FosB but has lost the ability in transfection assays to activate a promoter with an AP 1 site and to repress the c fos promoter . ^^^ Rather , delta FosB inhibits gene activation by Jun or Jun + Fos and inhibits repression of the c fos promoter by FosB or c Fos , presumably by competing with full length Fos proteins at the steps of dimerization with Jun and binding to DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of PDGF induced c jun and c fos expression by a tyrosine protein kinase inhibitor . ^^^ The expression of the proto oncogenes c fos , c jun , jun B and jun D was monitored in quiescent C3H10T1 / 2 fibroblasts after stimulation with PDGF . ^^^ The mRNA level of c fos , c jun and jun B , but not of jun D , was stimulated by PDGF . ^^^ The removal of PDGF and genistein was accompanied by an important increase in c fos , c jun and jun B mRNA expression , which correlated with the entrance of cells into G 1 phase . ^^^ This result also suggests that the mRNA levels of c jun , jun B and to a lesser degree c fos are positively regulated by tyrosine protein kinase activity , whereas jun D is negatively regulated . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern and Western blot analysis demonstrates that the mechanism by which GM CSF stimulates AP 1 enhancer activity involves increases in c jun and c fos mRNA levels , and increases in Jun protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have characterized the expression of c Jun , JunB , JunD , c Fos , and FosB proteins following serum stimulation of quiescent Swiss 3T3 cells by immunoprecipitation analyses . ^^^ We have shown that c Fos and FosB form complexes in vivo with the different Jun proteins and that JunB complexes are predominant . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that expression of both c jun and c fos , which encode proteins that participate in formation of the AP 1 complex , is rapidly induced by two different DNA damaging agents : UV and H2O2 . ^^^ Interestingly , the c jun gene is far more responsive to UV than any other immediate early gene that was examined , including c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To understand the early events by which neurotransmitters could effect genetic responses , we have studied the induction of two immediate early genes , c fos and c jun . ^^^ Using the stable acetylcholine analog carbachol to activate muscarinic receptors ( mAChR ) in a glial cell line ( 1321N1 ) , we show that c fos and c jun mRNA levels are transiently increased , reaching a maximum at 30 min after agonist addition . ^^^ Experiments in which the actions of carbachol are blocked by adding atropine at various times demonstrate that only 1 . 5 min of agonist stimulation is needed to give maximal increases in c fos or c jun mRNA at 30 min . ^^^ In cells in which protein kinase C has been down regulated , carbachol no longer stimulates c fos or c jun expression , indicating a critical role for protein kinase C in these responses . ^^^ In cells loaded with bis ( o aminophenoxy ) ethane N , N , N ' , N ' tetraacetic acid ( BAPTA ) to buffer increases in cytosolic [ Ca2+ ] , mAChR mediated induction of c fos is markedly reduced ; in contrast there is enhanced c jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
LRF 1 alone can bind DNA , but it preferentially forms heteromeric complexes with c Jun and Jun B and does not interact with c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Insulin binding to its receptor stimulates DNA synthesis and cell division and induces an increase in abundance of mRNA for c fos , c jun , Krox 20 , Krox 24 ( zif / 268 ) , fra 1 , jun B , c myc , and JE . ^^^ There were no detectable levels of mRNA for genes c fos and Krox 20 and no increase in level of mRNA for c jun ( INS type 1 genes ) as compared to the quiescent WT . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , the expression of c fos , c jun and jun B results in an increased binding of protein complexes to AP 1 binding sites . . ^^^ Growth hormone induces expression of c jun and jun B oncogenes and employs a protein kinase C signal transduction pathway for the induction of c fos oncogene expression . ^^^ GH rapidly and transiently induced the expression of c jun and jun B in concert with the already reported expression of c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The product of the fos related fosB gene shares many properties with c Fos such as inducibility by growth factors , complex formation with members of the Jun family and cooperative binding with Jun to the TPA response element ( TRE ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proteins encoded by the proto oncogenes c fos and c jun ( Fos and Jun , respectively ) form a heterodimeric complex that regulates transcription by interacting with the DNA regulatory element known as the activator protein 1 ( AP 1 ) binding site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results further demonstrate that etoposide induced c jun expression occurs in association with the appearance of c fos transcripts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , FosB 2 can not only suppress the transcriptional activation by c Fos and c Jun of promoters containing an AP 1 site but also interferes with the transforming potential of viral and cellular Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of the c fos and c jun proteins after ischemia demonstrated an increase in the formation of a functional transcriptional complex and association with the AP 1 binding region . ^^^ Ten minutes of bilateral carotid occlusion in the Mongolian gerbil was found to increase the messenger RNA for both the c fos and c jun protooncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Unregulated expression of c Jun or c Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells . ^^^ We present evidence that oestrogen receptor activity in human MCF 7 breast cancer cells is reduced by over expression of c Jun or c Fos proteins and to a lesser extent by Jun B overexpression . ^^^ Finally , we suggest that c Jun and c Fos act independently to inactivate the oestrogen receptor . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 family of transcription factors , which includes the proto oncogene products c Jun and c Fos , controls the stimulation of cellular genes by growth factors and the expression of oncogenes , including src and ras . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with this result , these cell lines expressed increased levels of mRNAs encoding the AP 1 proteins , c Fos , Fra 1 , c Jun , JunB , and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further , in mouse F 9 cells cotransfected with c Fos and c Jun expression plasmids , the transfected wild type stromelysin promoter activity was increased 57 fold whereas no transactivation was detected for an AP 1 mutant stromelysin promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mutant Jun lacks an activation domain and blocks stimulation of transcription by several oncoproteins , including Ras , 5 Src , polyoma middle T , c Jun and c Fos , as well as by the tumour promoter 12 O tetradecanoylphorbol 13 acetate ( TPA ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is concluded that a ) the inhibition of transforming growth factor beta autostimulation by HDL 3 plus LDL may involve reduced AP 1 activity via a reduction of c fos expression by the lipoprotein combination and b ) the ratio HDL 3 : LDL might influence the pathogenesis of arteriosclerosis via growth related events in the arterial wall . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Similar effects of these kinase inhibitors and activators were also observed with the expression of various immediate early genes that have been proposed to mediate the transcriptional effects of NGF , including c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine whether these proteins are required for cell cycle progression , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , c Jun , JunB , and JunD , and antibodies that recognize either the Fos or the Jun family of proteins , into Swiss 3T3 cells and determined their effects in cell cycle progression by monitoring DNA synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Degradation of transcription factors , c Jun and c Fos , by calpain . c Jun protein , and AP1 / PEA1 transcription factor component , is a typical short lived protein , and like other short lived proteins such as c Fos , contains PEST regions . ^^^ Calcium dependent neutral protease ( calpain ) , a candidate for the degradation of PEST containing proteins , digests c Jun and c Fos efficiently in vitro . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis showed that on addition of EGF and insulin the level of GST P mRNA was also elevated and expressions of the nuclear oncogenes c jun and c fos were enhanced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The PMA induction of c fos mRNA correlated well with TNF gene induction ; expression of genes encoding other proteins in the AP 1 complex ( junB and junD ) were also induced by PMA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
H2O2 increased the expressions of c fos , c jun , egr 1 and JE genes which are known to be early response genes and are induced by mitogenic stimuli in many types of cells . ^^^ H2O2 at 0 . 1 0 . 2 mM induced maximal expressions of c fos and c jun , whereas 0 . 3 mM H2O2 was required for induction of stress induced heme oxygenase mRNA . ^^^ The inductions of c fos and c jun were inhibited by 50 microM H 7 , a protein kinase inhibitor that is relatively specific for protein kinase C , but were not affected by H 9 , relatively specific for cAMP dependent protein kinase . ^^^ Thus , H2O2 seemed to induce c fos and c jun by activating protein kinases distinct from protein kinase C . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this paper we show that epidermal growth factor ( EGF ) and 12 O tetradecanoyl phorbol 13 acetate ( TPA ) induced expression of the c fos and c jun protooncogenes is decreased in microgravity , while no effect of gravity changes was observed on A 23187 and forskolin induced expression of these genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In trans activation experiments , we showed that cotransfection of c fos and c jun expression plasmids markedly increased the transcription rate of chloramphenicol acetyltransferase reporter plasmids containing three synthetic ET 1 AP1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The immediate early genes c fos and c jun are differentially expressed in the rat adrenal gland after capsaicin treatment . ^^^ In situ hybridization histochemistry was used to study the expression of c fos and c jun mRNA in the rat adrenal gland of untreated and capsaicin treated rats . ^^^ After capsaicin ( 25 mg / kg , s . c . ) , a rapid increase in both c fos and c jun mRNA levels was observed in adrenal medulla . ^^^ Capsaicin also induced an increase in c fos mRNA levels in all 3 cortical layers , especially in the zona glomerulosa , whereas only small changes in c jun mRNA levels were seen in zona fasciculata and reticulata . ^^^ The present results indicate that c fos and c jun mRNA levels are both increased in the adrenal gland after capsaicin treatment , although the time course , magnitude and regional distribution of these increases differed for the two mRNAs . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The immediate early genes c fos , c jun and NGFI A are rapidly and transiently expressed in neurons of the superficial dorsal horn following noxious sensory stimulation . ^^^ In contrast levels of c jun mRNA and protein like immunoreactivity ( but not c fos or NGFI A ) are massively increased within dorsal root ganglion cells and motor neurons following sciatic nerve section or crush . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of the expression of some growth factor induced early response genes in 5 sis overexpressing cells revealed : ( a ) high and constitutive c myc mRNA levels in SSV NRK cells ; ( b ) unaltered levels of fra 1 , fos B , jun B and krox 20 transcripts ; ( c ) high and constitutive FOS staining due to c FOS and FOS related protein ( s ) ; ( d ) constitutive c JUN and higher JUN D expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to test this hypothesis we have compared DNA replication , phospholipase C activation , and c jun and c fos nuclear protooncogene transcriptions stimulated by fetal calf serum ( FCS ) , vasoactive agents ( angiotensin 2 and vasopressin ) , and epithelial growth factor ( EGF ) in SHR and WKY rat cells . ^^^ Indeed , FCS stimulated inositol phosphate formation and c jun and c fos transcription , but none of these parameters was enhanced in SHR cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Short term stimulation ( up to 16 hours ) of interleukin 3 ( IL 3 ) dependent mouse bone marrow derived mast cells , Abelson transformed mouse liver derived mast cells , or rat basophilic leukemia cells by either IgE Ag or calcium ionophore A 23187 resulted in inhibition of their proliferation as measured by 3H thymidine incorporation and MTT ( tetrazolium ) assays , and in accumulation of the mRNAs of c fos , c jun , junB and slightly of junD proto oncogenes . ^^^ In addition , the expression of the mRNA of c jun and junB proto onogenes is not coordinately regulated with that of c fos during immunologic stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MCD peptide and dendrotoxin 1 activate c fos and c jun expression by acting on two different types of K+ channels . ^^^ Mast cell degranulating ( MCD ) peptide and Dendrotoxin 1 ( DTXI ) , two potent hyperexcitability inducing toxins acting on voltage dependent potassium channels , induce the expression of both c fos and c jun mRNA in i . c . v . treated rats . ^^^ The distribution of c fos and c jun expression has been analyzed by in situ hybridization . ^^^ Moreover , brain areas such as cerebellum which have high amounts of binding sites for both MCD and DTXI do not show any induction of c fos and c jun . ^^^ Lemakalim , a K+ channel opener , prevents the MCD induced activation of both ' immediate early genes ' in all brain areas but is unable to inhibit the induction of c fos and c jun induced by DTXI . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the effect of c Fos and / or c Jun co expression on transcription activation by the progesterone ( PR ) , glucocorticoid ( GR ) or androgen ( AR ) receptors using three different reporter genes and four different cell lines . ^^^ We found that c Fos could only inhibit , while c Jun could either inhibit or further stimulate receptor induced transcription . ^^^ All these effects were receptor , promoter , and cell type specific , and , importantly , the steroid receptors had non reciprocal effects on the transactivation ability of c Jun in the presence or absence of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of phorbol ester induced monocytic differentiation by dexamethasone is associated with down regulation of c fos and c jun ( AP 1 ) . ^^^ Previous studies have shown that treatment of human myeloid leukemia cells with 12 O tetradecanoylphorbol 13 acetate ( TPA ) is associated with induction of monocytic differentiation and expression of the c jun and c fos early response genes . ^^^ The present work demonstrates that the glucocorticoid dexamethasone inhibits TPA induced increases in c jun and c fos mRNA levels in U 937 leukemia cells . ^^^ Other studies have demonstrated that TPA induced monocytic differentiation and expression of the c jun and c fos genes in myeloid leukemia cells are regulated by protein kinase C ( PKC ) . ^^^ Nuclear run on assays demonstrate that : ( 1 ) induction of c jun and c fos expression by TPA is regulated by transcriptional mechanisms , ( 2 ) TPA induced expression of c jun and c fos does not require protein synthesis , and ( 3 ) TPA induced expression of both genes is inhibited at the transcriptional level by dexamethasone . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos and c jun proto oncogene expression is decreased in psoriasis : an in situ quantitative analysis . ^^^ The c fos and c jun proto oncogenes , whose products associate to form a heterodimeric transcription factor , are among the first genes to be expressed when certain cells are stimulated to either proliferate or differentiate . ^^^ In the present study , we used in situ hybridization with RNA to compare the expression and localization of c fos and c jun transcripts in 15 lesional and non lesional psoriatic skin samples . ^^^ Our data showed that c fos and c jun were expressed to an equivalent extent , both spatially and quantitatively , in all specimens tested . ^^^ These results were surprising because hyperproliferation was here associated with a decrease in proto oncogene expression , thus suggesting that c fos and c jun do not play a crucial role in the control of keratinocyte proliferation in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Signal ( s ) transduced through the wild type receptor led to transient induction of selected immediate early gene messages ( Egr 1 , c fos , Jun ) above basal levels . ^^^ However , the signal ( s ) generated after crosslinking of the 1 A alpha tail receptor either showed no effect ( c fos ) or actually repressed basal level expression of Egr 1 and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In transient transfection studies , we observed that the oncogenes c jun and c fos inhibit TR activities , while TRs inhibit induction of the c fos promoter and repress AP 1 site dependent gene activation . ^^^ The constituents of AP 1 , c Jun , and c Fos , vice versa , can inhibit TR induced gene activation in vivo , and c Jun inhibits TR DNA binding in vitro . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Functional analysis has shown that c jun enhances the activity of the ets 1 promoter , whereas the combination of c fos and c jun expressions has no synergistic effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
E 2 by itself , however , is poorly mitogenic and it does not induce genes from the jun family , whose gene products are necessary for heterodimerization with the c fos encoded protein ( Fos ) , leading to an important step in growth factor signalling pathways , stimulation of the 12 O tetradecanoyl phorbol 13 acetate responsive element ( TRE ) dependent transcriptional activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , these results demonstrate that AP 1 activity can be stimulated by phorbol ester without concomitant c fos induction . ^^^ Transfection experiments indicate that , in the absence of c Fos , only c Jun is an effective transactivator . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Each AP 1 site as well as a third AP 1 site near the promoter bound c Jun and Jun / Fos in vitro , and was activated by c Jun and c Fos in transfections . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also examined the regulation by okadaic acid of expression of the components of the AP 1 complex , c fos and c jun . c fos expression is dramatically stimulated by okadaic acid , whereas c jun expression is stimulated to a lesser extent . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Deregulated c fos expression in the rat pheochromocytoma cell line , PC 12 , causes pronounced downregulation of nerve growth factor ( NGF ) induced c fos and c jun activation , accompanied by a block in NGF induced differentiation of PC 12 cells . ^^^ The FOS expressing PC 12 cells were exposed to diverse agents such as NGF , epidermal growth factor ( EGF ) , basic fibroblast growth factor ( bFGF ) , interleukin 1 beta ( IL 1 beta ) , interleukin 6 ( IL 6 ) , dibutyryl cyclic adenosine 3 ' , 5 ' monophosphate ( db cAMP ) , and Ca ionophore ; and the expression of egr 1 , c fos , c jun , jun B , and jun D was analyzed . ^^^ Pronounced downregulation of c fos , c jun , and to a lesser extent jun B was observed on treatment with NGF , bFGF , db cAMP , and Ca ionophore , whereas EGF induced activation of these early response genes was not inhibited in FOS expressing PC 12 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c jun and c fos proteins also bound to both the somatostatin CRE and E3 / ATF binding sites , but CREB did not bind to AP 1 recognition sites nor was it capable of forming heterodimers with either c jun or c fos . ^^^ We wished to characterize CREB , c jun , and c fos binding to these sites in the somatostatin gene ( CRE ) and in the adenovirus early region 3 promoter ( E3 / ATF ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have studied the expressions of nine proto oncogenes ( c myc , N myc , c fos , C jun , p 53 , H ras , N ras , c raf , hst ) and two other genes ( PCNA , GST P ) during the spontaneous development of hepatocellular carcinomas ( HCCs ) in LEC rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In primary cultures of rat cerebellar neurons , a brief stimulation of glutamate receptors results in coordinated activation of a programmed early gene response involving increases in the amount of c fos , c jun , jun B , and zif / 268 mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of AtT 20 cells with IL 1 induced a transient and early stimulation of mRNA expression by both immediate early protooncogenes Fos and Jun ( mouse c fos and c jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The EGFR in the variant appeared to be an active part of the transmembrane signaling machinery since c fos and c jun mRNA accumulated after epidermal growth factor treatment , followed by EGFR and c myc mRNA accumulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Examination of immediate early transcription factor expression during the MDI regimen revealed that RA mediated an elevated , prolonged expression of c Jun mRNA accompanied by diminished expression of c Fos and Jun B mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , serum , which is mitogenic for these cells , induces c jun , c fos , and Egr 1 , but not gro expression . ^^^ These data imply that in A 375 C6 cells , both growth inhibitory and stimulatory signals can channel their action through c fos and c jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using this strategy for detecting leucine zipper interactions , we observed homo oligomerization between leucine zipper domains of the yeast protein GCN 4 and hetero oligomerization between leucine zipper regions from the mammalian transcriptional regulating proteins c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous studies have shown that IL 1 prepares T cells for replication by increasing the production of c jun , c fos , c myc , growth factors , growth factor receptors , and the response to growth factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the immediate early genes c fos and jun B was induced by 8 bromo cAMP on a rapid , but sustained time course , whereas induction of c jun expression was delayed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of transcription of c fos , fosB , c jun , junB and collagenase was studied as well as the mutation rate in the progeny of treated cells . ^^^ No transcription of c fos and c jun was observed in control and TPA treated cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , accumulation of mRNAs for the C FOS , C JUN , and EGR 1 genes increased markedly in TPA treated cells and preceded the induction of IL2R alpha mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When quiescent cells are stimulated with growth factors , phorbol esters , okadaic acid , or protein synthesis inhibitors , the early response genes , which include c fos and c jun , are rapidly induced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both positive and negative modulation of stromelysin transcription appear to utilize pathways that involve the protooncogenes c fos and / or c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , the characteristic serum stimulated transient increases in transcripts of three immediate early response genes , c fos , c jun and c myc are absent or much reduced when mitogenesis in ts LA 29 Rat 1 is induced by pp60v src . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
No increase was seen for c fos , NGFI B , c jun , jun D , SRF , or PC 4 mRNAs . ^^^ Stimulation of sensory fibers resulted in an increase in mRNA for NGFI A , c fos , SRF , NGFI B , and c jun in spinal cord neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fra 2 gene product formed a complex in cells with the c Jun protein , indicating that c fos and fra 2 share biological and biochemical functions . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The similar kinetics of induction of c fos and c jun emphasizes the functional significance of the fos / jun heterodimer in control of uterine cell proliferation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Chronic electroconvulsive seizures down regulate expression of the immediate early genes c fos and c jun in rat cerebral cortex . ^^^ Acute seizures and other stimuli that increase neuronal activity cause a rapid induction of the immediate early genes c fos and c jun , also referred to as nuclear proto oncogenes , in the nervous system . ^^^ In the present study , rats were administered one or more electroconvulsive seizures ( ECS ) and the responsiveness of c fos and c jun to an acute , `` test ' ' seizure was examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNase 1 footprint experiments demonstrated that a binding site for transcription factor AP 1 ( Fos / Jun heterodimer ) in the first intron of the NGF gene was protected following c fos induction . ^^^ Lesion of the sciatic nerve caused a rapid increase in c fos and c jun mRNA that was followed about 2 hr later by an increase in nerve growth factor ( NGF ) mRNA . ^^^ In primary cultures of these fibroblasts , CdCl 2 evoked a rapid increase in exogenous c fos mRNA , followed immediately by an increase in endogenous c jun mRNA and with a slight delay by an increase in NGF mRNA . ^^^ In fibroblasts of C3H control mice , CdCl 2 had no effect on the mRNA levels of the protooncogenes c fos and c jun or of NGF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the mechanisms of regulation of c myc , c fos , and c jun at the early stages of liver regeneration in mice . ^^^ Furthermore , we show that in normal mice c fos and c jun mRNA levels and transcriptional rates increase within 30 min after partial hepatectomy . c fos transcriptional elongation was restricted in nongrowing liver , but the block was partially relieved in the regenerating liver . ^^^ Nevertheless , for both c fos and c jun , changes in steady state mRNA detected after partial hepatectomy were much greater than the transcriptional increase . ^^^ In the regenerating liver of H 2K / c myc mice , c fos and c jun expression was diminished , whereas mouse c myc expression was enhanced in comparison with that in nontransgenic animals . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos , c jun , and c myc genes is regulated by heat shock in human lymphoid cells . ^^^ The effect of heat shock on the expression of the nuclear protooncogenes c fos , c jun , and c myc was studied in human lymphoid cells . ^^^ Heat shock caused an increase in c fos and c jun mRNA levels and a decrease in c myc mRNA levels in pre B ( Hyon ) and T ( DND 41 ) cell lines as well as in freshly isolated normal human thymocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Addition of TPA to undifferentiated P 19 cells does not result in induction of c jun , jun B and c fos , while these genes are transiently induced in RA differentiated P 19 cells . ^^^ Jun D is constitutively expressed at constant levels in both undifferentiated and differentiated P 19 cells , while jun B and c fos are not expressed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The dependence upon intracellular Ca2+ transients for transcriptional induction by endothelin appears to be a characteristic of VL 30 expression , as 1 , 2 bis ( o aminophenoxy ) ethane N , N , N ' , N ' tetraacetic acid treatment did not prevent the endothelin induced transcription of the protooncogenes c jun and c fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The products of two cellular proto oncogenes c fos and c jun form a heterodimeric complex that contribute to the DNA binding activity referred to as AP 1 ( activator protein 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of PC 12 pheochromocytoma cells neuronal differentiation upon treatment with nerve growth factor ( NGF ) is accompanied by a coupled stimulation of c fos and c jun oncogene transcription . ^^^ We found that induction of c fos and c jun proto oncogene mRNAs levels following the endocrine differentiation of PC 12 cells by sodium butyrate is uncoupled . ^^^ While c fos mRNA level increased within minutes , the content of c jun mRNA was significantly elevated only 24 hours after treatment . ^^^ Continuous presence of sodium butyrate for 72 hours resulted in stable high levels of c fos and c jun mRNAs . ^^^ Gel shift analysis showed unimpaired capacity of the butyrate induced c Fos protein to participate in the formation of transcriptional complexes with the Jun / AP 1 protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The p68c ets 1 protein cooperates with c Fos and c Jun ( components of AP 1 ) for activation of transcription from the oncogene responsive domain of the polyoma enhancer , indicating that combined activity of all three oncoproteins could be involved in the response of cells to growth stimuli . . ^^^ The c ets proto oncogenes encode transcription factors that cooperate with c Fos and c Jun for transcriptional activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto oncogenes c fos and c jun and activation of protein kinase C . ^^^ We examined the necessity of specific secondary ( protein kinase C ) and tertiary ( c fos and c jun protein products ) messengers in the transactivation of stromelysin gene expression by epidermal growth factor ( EGF ) . ^^^ In reconstitution experiments , neither c fos , c jun , nor C kinase activation alone induced significant stromelysin expression . ^^^ Overexpression of c fos and c jun was able to induce stromelysin to a level similar to that of the growth factor , and stimulation of protein kinase C activity augmented this induction . ^^^ The data suggest that the EGF induction of stromelysin in rat fibroblasts procedes through a pathway involving c fos , c jun , and protein kinase C . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Integrity of FOS B leucine zipper is essential for its interaction with JUN proteins . fos B encodes a nuclear protein with 70 % homology to c fos , whose expression is transiently induced during the G0 / G1 transition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present results similarly demonstrate that ionizing radiation increases levels of c fos transcripts as well as that of jun B , another member of the jun family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we report that Rb can repress c fos expression and AP 1 transcriptional activity in both serum induced and cycling 3T3 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both src and serum induced expression of the c fos and c jun genes in myeloid cells , resulting in transcriptional activation of the TGF beta 1 gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All three compounds increased steady state mRNA concentration of c fos , c jun and c myc proto oncogenes to comparable levels ( 2 hrs after treatment ) , whereas only 17 beta estradiol was found to stimulate significantly DNA synthesis ( 20 22 hrs later ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This sequence , denoted a `` composite ' ' glucocorticoid response element ( GRE ) , was bound selectively in vitro both by the glucocorticoid receptor and by c Jun and c Fos , components of the phorbol ester activated AP 1 transcription factor . ^^^ Indeed , c Jun and c Fos served as selectors of hormone responsiveness : the composite GRE was inactive in the absence of c Jun , whereas it conferred a positive glucocorticoid effect in the presence of c Jun , and a negative glucocorticoid effect in the presence of c Jun and relatively high levels of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Identification of an estrogen response element upstream of the human c fos gene that binds the estrogen receptor and the AP 1 transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report here that transport of the protein product of the c fos proto oncogene from the cytoplasm , where it is synthesized , into the nucleus , where it operates as part of the AP 1 transcription complex , is not spontaneous but depends on the continuous stimulation of cells by serum factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We find that , although a single dose of diacylglycerol , like phorbol esters , is sufficient to elevate mRNA levels of both the c jun and c fos protooncogenes , in contrast to phorbol esters there is no increase in either Jun protein or activation of AP 1 enhancer activity . ^^^ However , multiple doses of this agent given over 24 h stimulate repeated elevations in c jun and c fos mRNA , increases in Jun protein , and enhancer activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Adherence dependent increase in human monocyte PDGF ( B ) mRNA is associated with increases in c fos , c jun , and EGR 2 mRNA . ^^^ The increased PDGF ( B ) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the early growth response genes c fos ( maximal at 20 min ) , c jun , and EGR 2 ( maximal at 6 24 h ) . ^^^ The increase in c jun and EGR 2 , but not c fos , mRNA was also abrogated by cytochalasin D . ^^^ These observations suggest that adherence results in increases of c fos , c jun , EGR 2 , and PDGF ( B ) mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , PMA treatment results in the rapid induction of a program of immediate early gene expression ( including the c fos and c jun proto oncogenes , and an inducible zinc finger containing gene , egr l ) , and activates cardiac gene transcription as assessed by nuclear run on analyses . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we show , however , that omission of a single essential amino acid from the medium caused a marked rise in the mRNA levels of c myc , c jun , junB and c fos oncogenes and ornithine decarboxylase ( ODC ) in CHO cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear oncogenes c fos , c myc , and c jun belong to the early response group , whereas the metallothionein , osteopontin , and urokinase genes belong to the secondary response group . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun transcription in 3T3 F442A preadipocytes . ^^^ To investigate early events in GH action , we examined whether GH altered the expression of c fos and c jun mRNA in 3T3 F442A cells . ^^^ In 3T3 F442A preadipocytes , which differentiate in response to GH , treatment with GH for 15 30 min transiently increased the expression of c fos and c jun mRNA at GH concentrations in the physiological range ( 10 500 ng / ml ) . ^^^ Nuclear run on experiments indicated that the effect of GH on c fos and c jun occurred at the level of gene transcription , indicating that in the 3T3 F442A preadipocytes , GH acts similarly to other growth factors which induce c fos and c jun . ^^^ Taken together , these findings are consistent with coordinated expression of c fos and c jun playing an early role in responses to GH in 3T3 F442A cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that c myc , c fos , jun B , c jun and jun D mRNA expression is transiently increased soon after partial hepatectomy , jun and fos expression being induced earlier ( 30 min ) than that of c myc ( 1 2 h ) . ^^^ C fos , jun B and c jun mRNA expression is dramatically enhanced ( 50 fold ) while that of jun D and c myc is weaker ( less than 10 fold ) , but lasts longer . ^^^ When protein synthesis is inhibited by injection of cycloheximide , the expression of c myc , c fos , jun B , c jun and jun D mRNA is also transiently increased . ^^^ Differential regulation and expression of jun , c fos and c myc proto oncogenes during mouse liver regeneration and after inhibition of protein synthesis . ^^^ In order to obtain information in vivo about the possible relationships between early response gene products , we have analysed the expression of c myc , c fos and jun proto oncogenes in regenerating mouse liver . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of c fos and c jun expression in the rat supraoptic nucleus . 1 . ^^^ We have investigated induction of the nuclear proto oncogenes c fos and c jun in the rat supraoptic nucleus ( SON ) during physiological stimulation . 2 . ^^^ Dehydration ( 0 24 hr ) was associated with modest , but significant increases in both c fos and c jun mRNA at 8 hr and 16 hr as determined by Northern analysis of total RNA extracted from microdissected SON . ^^^ Prior to 8 hr , and beyond 24 hr , no consistent changes in c fos and c jun mRNA were found . ^^^ Levels of c fos and c jun mRNA in the hippocampus were not altered over 24 hr of dehydration . 3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transformed cells did not show constitutive expression of IL 2 or c fos mRNA , although the promoter regions of both IL 2 and c fos genes contain AP 1 sites that are expected to be targets for binding of Fos / Jun complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cell proliferation , phospholipase C activation , and c jun and c fos oncogene expressions were measured in both cultures under the same conditions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that the ovalbumin ERE binds a ubiquitous nucleoprotein complex containing oncoproteins c Fos and c Jun . ^^^ Mutagenesis indicates that the sequence 5 ' TGGGTCA 3 ' , containing the half palindromic ERE , is responsible for induction by phorbol esters of the ovalbumin promoter and is a target for c fos and c jun trans activation . ^^^ Transfection experiments reveal that c fos , c jun , and ER coactivate the ovalbumin promoter . ^^^ Direct ER interaction with the target sequence is not required , since an ER deleted for its DNA binding domain is functional in the coactivation with c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear proteins encoded by the c fos and c jun protooncogenes are expressed during the proliferation period of osteoblast phenotype development . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protooncogenes c fos and c jun encode nuclear proteins ( fos and jun , respectively ) that function cooperatively as a heterodimeric protein complex in the regulation of gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription factor activator protein 1 ( AP 1 ) is a protein fraction that contains c fos , c jun , and several other related proteins . ^^^ A direct role for c fos in AP 1 dependent gene transcription . ^^^ Although this protein fraction can stimulate transcription in vitro , the relative contributions of c fos and c jun to the transcriptional effect of AP 1 are not clear . ^^^ However , when the DNA binding assays were performed in the presence of both c jun and c fos , a marked increase in the affinity of c jun for the AP 1 site was observed . ^^^ These experimental results indicate that c fos and c jun proteins are required to reconstitute full AP 1 dependent transcriptional activation and directly demonstrate that c fos is a regulator of gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
E 2 by itself , however , is poorly mitogenic , and it does not induce genes from the jun family , whose gene products are necessary for heterodimerization with the c fos encoded protein ( Fos ) , leading to an important step in growth factor signalling pathways , stimulation of TPA responsive element ( TRE ) dependent transcriptional activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As early as 1 . 5 h after sciatic nerve section , c fos mRNA reached a maximum and then returned to basal level at 6 h , while c jun and jun B mRNA levels increased after 24 h and remained elevated for at least 8 days . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To understand the genetic control of this protein , Mongolian gerbils were studied for the possible expression of the ODC gene as compared to that of the inducible proto oncogenes c fos and c jun after transient bilateral carotid artery occlusion . ^^^ Total cellular RNA was isolated from gerbil brains by guanidine thiocyanate extraction and characterized by northern blot analysis for c fos , c jun , and ODC mRNA over reperfusion times . c fos and c jun expression rose rapidly with peak level reached at 60 min of reperfusion ( 70 10 control , p less than or equal to 0 . 01 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of growth hormone and serum on the expression of the proto oncogenes c jun and c fos in insulin producing cells . ^^^ Expression of the proto oncogenes c fos and c jun was analysed in the insulin producing rat tumor cell line , RIN 5AH . ^^^ Addition of fetal calf serum ( FCS ) to serum starved cells in the presence of cycloheximid induced a modest increase in c fos and c jun mRNA levels , whereas growth hormone ( GH ) in the presence of cycloheximid had little or no effect , when added to RIN 5AH cells maintained in 0 . 5 % FCS for 2 days prior to stimulation . ^^^ Activation of protein kinase C by phorbol ester lead to increased c jun and c fos mRNA levels , whereas activation of adenylate cyclase by forskolin increased c fos mRNA levels . ^^^ These results suggest that the effects of GH on insulin producing cells are not mediated by activation of c fos and c jun transcription . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , the ability of Et 1 to induce both second messenger production and transcription of c fos and c jun was largely independent of cellular pkC activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear proto oncogenes , c fos and c jun , are induced in response to a diverse array of extracellular stimuli . ^^^ The leucine zipper and DNA binding regions are highly conserved among the c fos and c jun families of related inducible genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proto oncogene products c Fos and c Jun form a complex which binds with high affinity to the 12 O tetradecanoylphorbol 13 acetate ( TPA ) response DNA element and which stimulates transcription of phorbol ester inducible genes . ^^^ Here , we demonstrate that the target sequence for mXBP is a consensus cyclic AMP response element ( CRE ) . mXBP is a member of the leucine zipper family of DNA binding proteins and has significant homology to oncoproteins c Fos and c Jun . ^^^ Complex formation is dependent on intact leucine zipper domains in both proteins . mXBP c Jun complexes can coexist with c Fos c Jun complexes and can bind with high affinity to CRE , but not to TPA response DNA element , sequences . ^^^ These results suggest that changes in the expression of mXBP / CRE BP 2 , c Fos , and c Jun , which alter the ratio of mXBP c Jun to c Fos c Jun complexes , would affect the relative expression of cyclic AMP and phorbol ester responsive genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Specifically , 50 70 % structural similarity was observed between the basic domain of the DNA binding region of the nuclear proto oncogene products c fos and its related antigen fra 1 , c jun and the cAMP responsive DNA binding protein CREB , with part of the N terminal half region of helix 1b of vimentin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Different promoter elements are required for the induced expression of c fos and c jun proto oncogenes by the 5 mos oncogene product . ^^^ We show here that expression of the 5 Mos protein leads to a transient transcriptional activation of the c fos and the c jun proto oncogenes in NIH 3T3 cells . ^^^ Various Mos mutants with decreased transforming activity have diminished trans acting activity on the c fos and c jun promoters . ^^^ These results suggest that the highly transforming 5 Mos protein exerts at least some of its effects through the induction of expression of the c fos and c jun protooncogenes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , the Zta protein , which possesses a similar basic domain to the conserved DNA binding region of the c Fos , c Jun , GCN 4 , and CREB protein family , proved to bind directly to the consensus AP 1 site in the collagenase 12 O tetradecanoylphorbol 13 acetate response element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The product of the Epstein Barr virus BZLF 1 gene encodes a protein which is related to c fos , it has been shown to bind specifically to a consensus AP 1 site , and its expression in latently Epstein Barr virus infected lymphocytes is sufficient to trigger the viral lytic cycle . ^^^ Furthermore , we found that a complex of c jun and c fos bound to the ZII domain . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proteins responsible for stimulation in 3T6 extracts can be separated from the ones responsible for AP 1 binding by chromatography . 3T6 c fos immunodepleted fractions are unable to activate AP 1 DNA binding activity in EC cell extracts , while c jun depleted fractions activate normally . ^^^ Moreover , in vitro translated c fos , but not c jun proteins , are able to stimulate binding in EC extracts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Unlike in other cells tested , the jun and c fos transcription factor mRNAs showed a prolonged biphasic induction response in K 562 cells during TPA treatment . ^^^ We suggest that the induction of EPA / TIMP and several other genes specific for the differentiating K 562 cells may be a consequence of the sustained activation of immediate early genes encoding transcription factors , such as jun and c fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the basis of the presence of limited amino acid similarity within a basic carboxy terminal domain , Zta has been proposed to be a highly divergent member of the c Jun / c Fos / GCN4 family of AP 1 binding proteins . ^^^ The relative binding affinity of Zta for oligonucleotides containing the 7 base pair c Fos AP 1 site TGAGTCA was twofold greater than that for the ZRE core motifs TGAGCAA , TG TGCAA , and TGAGTAA , but 10 fold greater than that for TGTGTCA , as measured by gel mobility retardation and competition DNA binding assays . ^^^ Furthermore , we show that a potential coiled coil helical domain adjacent to the basic domain of Zta can substitute for the leucine zipper of c Fos to produce a DNA binding protein that has a very stringent target DNA specificity and can only recognize symmetric 9 base pair AP 1 sites ( ATGAGTCAT ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 is a composite transcription factor , consisting of members of the jun and fos gene families . c jun and c fos are progenitors of oncogenes , suggestion that an important transcriptional event in cell transformation is altered activity of AP 1 , which may arise either indirectly by oncogene expression or directly by structural modification of AP 1 . ^^^ AP 1 is a composite transcription factor , consisting of members of the jun and fos gene families . c jun and c fos are progenitors of oncogenes , suggestion that an important transcriptional event in cell transformation is altered activity of AP 1 , which may arise either indirectly by oncogene expression or directly by structural modification of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Epstein Barr virus BZLF 1 gene product ZEBRA is a DNA binding protein that is partially homologous to c Fos , binds specifically to AP 1 sites , and can induce the lytic cycle in latently infected B lymphocytes . ^^^ In this article the interrelationship between ZEBRA and AP 1 is extended by the demonstration that ZEBRA can induce c Fos expression through AP 1 and `` AP 1 like ' ' sites present in the c fos promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While the GCR is a potent inhibitor of AP 1 activity ( Jun / Fos ) , both c Jun and c Fos are potent repressors of GCR activity . ^^^ Direct interaction between GCR and either c Jun or c Fos is demonstrated by cross linking and coimmunoprecipitation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes c fos and c jun express proteins targeted into the nucleus . ^^^ The data suggest that beta adrenergic receptor stimulation or exposure to 8 BrcAMP induces the early expression of the `` nuclear proto oncogenes ' ' c fos and c jun before changes are noted in salivary epithelial cell proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro translated c Jun and c Fos were also found to bind to the NF S binding domain consisting of the sequence TGA ( A / G ) TCA that are known to be recognized by c Jun / AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Enhanced expression of one or more of the nuclear protooncogenes : c myc , N myc , c fos , c jun and jun B was frequently observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , we found no evidence supporting the possibility that the RA dependent repression could be due to RAR binding to the AP 1 binding site or to the AP 1 components c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
At concentrations that elicited a comparable initial rate of inositol phosphate release ( 10 nM for thrombin and 0 . 1 mM for carbachol ) , both agents gave rise to an identical calcium signal and equally stimulated Na+ / H+ exchange and the transcription of the early genes c jun , c fos , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neurokinin A induces c fos , c jun , and c myc expression in L 6 rat myoblasts . ^^^ We demonstrate a relationship between NKA treatment and induction of c fos , c jun and c myc mRNA expression in serum deprived L6J1 rat myoblasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neurokinin A induces expression of the c fos , c jun , and c myc genes in rat smooth muscle cells . ^^^ In the present experiments , we have studied intracellular pH and expression of the proto oncogenes c myc , c jun and c fos in smooth muscle cells exposed to mitogenic concentrations of neurokinin A . ^^^ Growth arrested smooth muscle cells stimulated with neurokinin A responded with an amiloride sensitive intracellular alkalinization , indicating Na+ / H+ antiport activation . c myc and c jun mRNA expression was only slightly elevated by neurokinin A , while c fos expression underwent a more pronounced increase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of adenosine receptors induces c fos , but not c jun , expression in neuron glia hybrids and fibroblasts . ^^^ Both lines responded with a concentration dependent transient increase in c fos , but not c jun , mRNA content after treatment with either agonist . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , we show that IL 1 and 12 O tetradecanoyl phorbol 13 acetate transiently induce c jun and c fos expression and that retinoic acid inhibits IL 1 and 12 O tetradecanoyl phorbol 13 acetate induction of c fos , but not c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Within minutes of addition , agents such as nerve growth factor ( NGF ) , epidermal growth factor ( EGF ) , basic fibroblast growth factor ( bFGF ) and dibutyryl cyclic AMP ( db cAMP ) rapidly activate cellular immediate early genes such as c fos , c jun , jun B , and egr 1 . fra 1 , a member of the immediate early gene family , follows a distinctly later time course of induction than c fos , c jun , jun B , and egr 1 , suggesting that fra 1 may attenuate the action of genes induced earlier . ^^^ Transcriptional activation of c fos , c jun , jun B , and egr 1 by NGF , EGF , and db cAMP was down regulated to a varying extent whereas NGF induced ornithine decarboxylase ( ODC ) was not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Most notably , our results and those of others demonstrate that seizures increase the expression of messenger RNAs from immediate early genes ( c fos , c jun , and NGFI A ) which encode proteins that may mediate neuropeptide gene regulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine if hepatocytes of protein deprived ( PD ) rats have been `` primed ' ' for replication , we examined changes in protooncogene expression in livers of PD rats to see if they would mimic the pattern of gene expression that is induced early after partial hepatectomy . c jun , c myc , and p 53 mRNAs were elevated in livers of PD rats , while c fos and c ras genes were not expressed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein products of the c fos and c jun proto oncogenes ( Fos and Jun , respectively ) form a heterodimeric protein complex that interacts with the activator protein 1 ( AP 1 ) binding site and regulates gene transcription in response to extracellular stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To study the mechanism ( s ) of vascular smooth muscle cell proliferation in vivo , mRNA levels of c fos , c jun , and c myc were determined by Northern blot analysis following vascular balloon de endothelialization ( BDE ) . ^^^ Medial smooth muscle cells ( SMC ) were separated and studied by enzymatic digestion of the vessel wall . mRNA levels of c fos and c jun from aortic smooth muscle cells ( SMC ) were simultaneously induced within 30 minutes of BDE and declined to baseline by 1 . 5 hours , c myc mRNA did not begin to increase until 1 hour after vascular injury . ^^^ Smooth muscle cells derived from enzyme treated control aortae that did not undergo BDE expressed c fos and c jun , but showed no evidence of c myc message . ^^^ In contrast , nonenzymatically treated , non BDE whole aortae ( containing both media and adventitia ) demonstrated a prominent c myc signal , but failed to express c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When results were normalized according to these reference transcripts , there was no increase in the expression of c myc , c Ha ras , c erbB ( EGF receptor ) , c jun , or transforming growth factor beta ( TGF beta ) transcripts in psoriatic lesions , and lesional c fos transcripts were decreased relative to normal skin . ^^^ Placement of normal or psoriatic tissue in organ culture for 2 to 4 h resulted in strong induction of c fos , c jun , and c myc transcripts , but not of the other genes studied . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These genes , zif / 268 , c fos , c jun , and jun B , encode sequence specific DNA binding proteins thought to act as transcription regulatory factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of differentiation to macrophages in two different clones of myeloid leukemic cells by the hematopoietic regulatory proteins interleukin 6 ( IL 6 ) , or by granulocyte macrophage colony stimulating factor ( GM CSF ) or interleukin 3 ( IL 3 ) , is shown to be associated with sustained accumulation of c jun , jun B , and c fos mRNA that code for proteins that form complexes that are transcription factors ( AP 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this paper we show that microgravity reached in a sounding rocket strongly decreases epidermal growth factor ( EGF ) induced expression of the proto oncogenes c fos and c jun , which are both implicated in the regulation of proliferation and differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phorbol ester induced differentiation of human B chronic lymphocytic leukaemic cells was found to be preceded by a rapid transient induction in expression of the c jun proto oncogene , which paralleled that of c fos . ^^^ Induced expression of c myc but not of c fos / c jun proto oncogenes was markedly higher in a proliferating variant leukaemic cell population compared with that seen in typical lymphocytic leukaemia cells . ^^^ These data suggest that the c fos / c jun nuclear oncogenes play a role in induced differentiation , whilst c myc is more important in the proliferative response of B lymphocytes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this article James Morgan and Tom Curran detail a stimulus transcription coupling cascade , involving the products of the proto oncogenes , c fos and c jun , that operates in many cell types including neurons . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proenkephalin mRNA increased in the hippocampus during seizure just after an increase in c fos and c jun expression was detected . ^^^ Furthermore , c fos and c jun stimulated transcription from this control region synergistically in transactivation assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of c jun and jun B with or without c fos into F 9 teratocarcinoma cells results in decreased trans activation of AP 1 compared with either gene alone . ^^^ B inhibits and c fos stimulates the transforming and trans activating activities of c jun . ^^^ We have cloned the human jun B gene and determined its sequence and transforming and trans activating activities . jun B is less potent that c jun in transforming and immortalizing primary rat embryo cells in cooperation with activated ras ( effects enhanced by c fos and TPA ) ; unlike c jun , jun B does not transform Rat 1A cells alone . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos protein can trans activate AP 1 dependent gene expression and trans repress the c fos promoter . ^^^ Although we find that trans repression is enhanced by coexpression of c Jun , it does not require any of the AP 1 or ATF sites in the mouse c fos promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Platelet activating factor ( PAF ) elicits a rapid and transient activation of the proto oncogenes c fos and c jun in SH SY5Y neuroblastoma cells , but only to a minor extent in Molt 4 T lymphocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proteins encoded by c jun , c fos , and several fos related genes all participate in a complex that interacts with the AP 1 consensus DNA sequence , previously shown to be important for the `` transcriptional activation ' ' of certain genes . ^^^ Depolarization of neurons either in culture or in vivo results in the rapid , calcium dependent induction of several , so called , immediate early genes ; the prototypes being c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional activation of c fos , c jun , and ornithine decarboxylase ( ODC ) by NGF was down regulated , whereas expression of egr 1 was unaffected in PC 12 fos clones . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes jun B , c fos , and to a lesser extent jun D were stimulated by increasing the intracellular concentration of cAMP , whereas the TPA stimulation of c jun and c myc was inhibited under these conditions . ^^^ Activation of the signal transduction pathways mediated by protein kinase A ( PKA ) or protein kinase C ( PKC ) led to different responses of several serum inducible genes including the jun gene family , c fos , c myc , krox 20 and krox 24 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both interleukin 1 alpha and tumor necrosis factor elicited a rapid transient elevation in the steady state mRNA levels of c fos , c jun , and JE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MLA 144 cells contained only trace amounts of c fos and c jun by immunoblot analysis , suggesting that the proteins specifically binding to the GALV AP 1 site were distinct from c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When quiescent cells re enter the cell cycle approximately 60 genes become up regulated , including proto oncogene c fos , the jun family , and c myc ( Zipfel et al . , 1989 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The simultaneous presence in cell extracts of proteins related to both AP 1 and Fos with similar sequence recognition properties was demonstrated by photo cross linking to FSE 2 DNA and immunoprecipitating with antibodies directed toward c fos or 5 jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It encoded a protein that shared several regions of extensive amino acid homology with Fos ( including the region that showed similarity to both the yeast GCN 4 regulatory protein and the protein encoded by the jun oncogene ) , although its nucleotide sequence was considerably diverged from that of the c fos gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , there exist five elements whose sequence is nearly identical to the inner core 10 nucleotide region ( CCATATTAGG ) of the c fos serum response element , four Sp 1 consensus sequences , two AP 1 target sequence analogs , and two potential cAMP response elements . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Administration of the convulsants pentylenetetrazole ( Metrazole ) or picrotoxin to rats caused a dramatic increase in mRNAs of four putative transcription factor genes , zif / 268 , c jun , jun B , and c fos , in neurons of the hippocampus and dentate gyrus , as well as other areas of the cerebral cortex , including pyriform cortex and cingulate cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , sequences similar to transcriptional enhancer elements such as the c fos serum responsive element and the consensus sequences for cAMP induction , activator protein 1 binding , and the glucocorticoid receptor binding are identified within the highly conserved 5 ' flanking regions of the genes from the two species . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The membrane proximal proline rich sequence of the cytoplasmic domain of IL 5R alpha was found to be essential for the IL 5 induced proliferative response , expression of nuclear proto oncogenes such as c jun , c fos and c myc , and activation of Bruton ' s tyrosine and JAK 2 kinases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Accumulation of Fos and Jun immunoreactivities in neurons and glia was generally consistent with the distribution of c fos mRNA induction observed in slices , and the neuronal component of this response was comparable to the expression of these proteins observed after transient ischemia in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To elucidate the biological role and regulation of follicular IGF 1 , we have analyzed individual follicles with respect to IGF 1 production , DNA synthesis , and c fos and c jun expression , since AP 1 complex components have been implicated both in regulation of IGF 1 gene expression and cell proliferation . ^^^ Granulosa cell DNA synthesis is strictly correlated with the presence of insulin like growth factor 1 and absence of c fos / c jun expression . ^^^ IGF 1 mRNA localization , bromodeoxyuridine ( BRDU ) incorporation , and c fos and c jun immunoreactivity were compared in serial sections from prepubertal and mature rat ovaries . ^^^ Both c fos and c jun are readily detected in granulosa cells of luteinized follicles where IGF 1 mRNA is never found . ^^^ Immunoreactive c jun but not c fos is detected in granulosa cells of atretic follicles , while neither c fos nor c jun is detected in IGF 1 mRNA positive granulosa cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis demonstrated that a priming dose of apomorphine significantly increased the messenger RNA signals for c fos , c jun , ngfi A and jun B in denervated striatum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Administration of kainate to rats caused a profound increase in messenger RNAs of the transcription factor genes c fos and c jun in the dentate gyrus , followed by an increase in the level of the transcriptional complex activator protein 1 in hippocampal neurons . ^^^ Furthermore , our present results suggest that the transcription factors , c fos , c jun and activator protein 1 complex may be involved in the process of inducing the hippocampal proenkephalin gene , while these factors might be differently involved in regulation of prodynorphin gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interestingly , however , UT 16 cells exhibited altered binding activity of AP 1 complexes , decreased ability to induce c jun and c fos gene expressions , and failure to differentiate to a monocytic lineage . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BaP / MeoA cells acquired the greatest proliferative enhancement and exhibited unregulated c jun and c fos gene expression under growth arrested and serum stimulated conditions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the hypothesis that a central dopaminergic mechanism may regulate hepatic c fos and c jun gene expression following peritoneal sepsis . ^^^ METHODS : First , dopamine or vehicle was instilled into a stereotaxically placed intracerebral ventricular ( ICV ) cannula with or without D 1 ( SCH 23390 ) or D 2 ( haloperidol ) antagonist pretreatment in a rat model , and the effect on hepatic c fos or c jun protein expression was investigated . ^^^ Second , we investigated the effect of haloperidol and vehicle treatment following cecal ligation and puncture ( CLP ) induced sepsis with respect to hepatic c fos protein expression , c jun protein expression , and survival . ^^^ RESULTS : Intracerebral ventricular dopamine treatment increased hepatic c fos immunoreactive protein but had no effect on hepatic c jun immunoreactive protein expression . ^^^ Haloperidol treatment significantly increased CLP induced hepatic c fos and c jun protein expression and improved survival following CLP . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription of growth response genes such as c fos , c jun , and c myc were induced by PDGF BB , and their induction was suppressed , particularly c myc , by incubating SMCs with PDGF BB plus SB . ^^^ Similarly , preincubation of cells with SB for 30 minutes and subsequent incubation in PDGF BB plus SB diminished PDGF BB induced transcription of c fos , c jun , and c myc . ^^^ However , SB by itself had no significant effect on c fos , c jun , and c myc transcription . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mouse 3T3 fibroblasts lacking c fos were employed to demonstrate an essential function of the UV inducible transcription factor AP 1 ( Fos / Jun ) in the response to the cytotoxic effects of short wavelength ultraviolet ( UVC ) radiation . ^^^ Transcriptional induction of the c Fos target genes collagenase 1 , stromelysin 1 and stromelysin 2 by UV is almost absent in cells lacking c fos which correlates with a reduced UV induction of AP 1 DNA binding and transactivation activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It led to an accumulation of milk in the glands and was accompanied by an induction of protein kinase A , AP 1 DNA binding activity and elevated c fos , junB , and junD mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Characterization of changes in GnRH receptor ( GnRH R ) , c fos , and c jun messenger ribonucleic acids during the ovine estrous cycle . ^^^ The present studies were conducted to 1 ) characterize in detail the changes in GnRH R gene expression during the 16 day ovine estrous cycle , 2 ) determine whether or not changes in GnRH R gene expression during the estrous cycle are paralleled by alterations in the expression of c fos and c jun mRNAs , and 3 ) determine whether GnRH can induce expression of c fos and c jun mRNAs . ^^^ Changes in c jun mRNA levels , in general , paralleled changes in GnRH R mRNA concentrations , being highest on the day before estrus and declining thereafter . c Fos mRNA followed a different time course than c jun mRNA , remaining elevated from Day 8 prior to estrus until the onset of estrus . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study we analysed , by in situ hybridization , the effects of an extremely localized mechanical brain injury , obtained by the simple needle insertion ( 30 g ) in rat hippocampus or cortex , on the expression of several immediate early genes ( c fos , fosB , c jun , junB , junD , zif / 268 ) . ^^^ Maximal effects are detected between 30 and 60 min with the following rank order of induction : zif / 268 > c fos > junB > fosB > c jun > junD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nicotine administration by injection increased the phosphorylation of CREB and induced c Fos protein without affecting members of the jun family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , they fail to undergo insulin stimulated internalization , do not regulate the phosphorylation of insulin receptor substrate 1 , and are unable to mediate an insulin stimulated increase in DNA synthesis and c jun and c fos expression . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transplants were derived from newborn donor rats and were analyzed immunocytochemically for the presence of c JUN , KROX 24 , and c FOS transcription factors 5 months after grafting . ^^^ The expression and distribution patterns of these genes in the host hippocampus were identical to those in hippocampal neurons of normal untreated animals . c JUN , KROX 24 , and c FOS labeled neurons were also present in the transplants , where KROX 24 and c FOS exhibited a distribution similar to host hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gastrin dose dependently stimulated AR 4 2J cell mRNA content of both c fos and c jun , two genes known to function in regulating cell proliferation , but G Gly had no effect . ^^^ These data support the notion that gastrin stimulates cell proliferation by inducing c fos and c jun gene expression , while G Gly acts by post translationally regulating early gene transcriptional activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot and gel mobility shift assays showed that 135 cGy of ionizing radiation induced c jun and c fos gene expression , AP 1 binding activity , as well as bFGF gene expression in MCF 7 / ADR cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There were no differences in the amount of messenger RNA detected for the components of AP 1 , c Fos and c Jun , nor in the sequences of these messenger RNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , the treatment provoked a biphasic alteration of the c fos mRNA level , consisting of a slight increase between 0 . 5 and 3 h followed by a greater increase between 12 and 48 h , while it caused a single increase between 12 and 48 h in c jun mRNA level . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We showed that IGF 1 and 2 did not modify the expression of c fos or c jun proteins during short time exposures but both factors enhanced c jun phosphorylation which suggests that this phenomenon could be involved in IGFs regulated gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In preliminary experiments we noted that partial hepatectomy , a procedure which results in a sharp rise in the level of the oncoproteins c Fos and c Jun , also causes a transient induction of the messenger RNA corresponding to clone RAP 01 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The hepatitis B virus transactivator was able to activate TRE ( 12 O tetradecanoylphorbol 13 acetate response element ) directed transcription in different cell lines , including HepG 2 , HeLa , CV 1 , and PLC / PRF / 5 cells . pX induced AP 1 activation in HepG 2 cells was associated with an increase in the DNA binding activity of c Jun / c Fos heterodimers , which was not dependent either on an increase in the overall amount of c Fos and c Jun proteins in the cells or on formation of dimers between pX and the two proteins , thus suggesting the involvement of posttranslational modifications of the transcription factor . ^^^ Induction of the DNA binding activity of c jun / c fos heterodimers by the hepatitis B virus transactivator pX . ^^^ The observation that the overexpression of c Jun and c Fos in the cells results in a strong augmentation of the effect of pX on TRE directed transcription is additional evidence indicating the involvement of posttranscriptional modifications of c Jun / c Fos heterodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In situ hybridization analysis using radiolabelled oligonucleotide probes confirmed this spatial and temporal separation between c fos and c jun expression within the striatum and extended it further , showing that , whilst jun mRNA displayed very similar expression characteristics to those of c fos mRNA , both fos B mRNA and jun D mRNA exhibited induction patterns closely resembling those of c jun mRNA . ^^^ The rapid ( 2 h ) and transient induction of c fos / jun B may well be a response to NMDA receptor activation , whereas the molecular signal for the late ( 24 h ) and sustained induction of c jun / fos B / jun D is currently a focus for our investigations . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hypergravity as low as 50g transiently stimulated cultured mouse osteoblastic cells ( MC3T3 E 1 ) to induce early response genes such as c fos and egr 1 , whereas expression of c jun was marginally affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In gel retardation analysis , FK 506 had little effect on the binding to the AP 1 site of PMA / ionomycin induced nuclear factors , which were recognized with anti JunD or c Fos antibody . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Colocalization of NDP with c Jun , JunB , JunD , c Fos , FosB and Krox 24 transcription factors was investigated in neurons of lumbar spinal cord . c Jun , JunB , c Fos and Krox 24 reached their maximal levels of expression 2 h after FOR and returned to basal levels after 10 h . ^^^ In a low number of NDP neurons , suprabasal immunoreactivity of JunB , c Fos and Krox 24 proteins was visible up to 10 h , and of JunD and FosB up to 24 h in sDH neurons ; c Jun was not expressed in NDP labelled neurons of sDH , but , similar as JunD , showed basal colocalization in preganglionic sympathetic and parasympathetic neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of GnRH receptors in cultured pituitary cells and alpha T 3 1 gonadotrophs caused prominent , but transient , increases in messenger RNAs for primary response genes ( PRGs ) including c fos , c jun , and junB . ^^^ GnRH induced stimulation peaked at 30 min and was dose related , with similar EC 50 values ( approximately 1 nM ) for all three PRGs and higher maximum responses for junB than for c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the products of immediate early genes such as c fos , c jun , and egr 1 function in many signaling pathways governing cellular responses to external stimuli , we sought to determine whether sustained contractile activity induces their expression in skeletal muscle . ^^^ Northern and Western analysis demonstrated marked but transient inductions of c fos , c jun , and egr 1 mRNA and protein within the first 24 h . ^^^ Longer durations of stimulation were associated with a secondary and sustained rise in the abundance of c fos , c jun , and p88egr 1 protein that , surprisingly , was not accompanied by detectable changes in mRNA . ^^^ These findings reveal a complex pattern of c fos , c jun , and egr 1 expression in response to nerve stimulation and suggest that these proteins could function in regulatory pathways that modify muscle phenotype . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It was screened by Northern hybridization for oncogenes , including H ras , c raf 2 ( c raf1p1 ) , c kit , c myc , c myb , c fos , Fim 1 , c jun , ski , and c mos , which are believed to contribute to B cell differentiation and maturation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have used primary neuronal cultures prepared from fetal cerebral hemispheres to investigate the effects of different glutamate receptor agonists and antagonists on the expression of transcription factor encoding genes , such as c fos , fosB , c jun , junB , junD , c myc , and zif / 268 . ^^^ The addition of glutamate ( 100 microM ) to the culture medium rapidly activated c fos , fosB , c jun , junB and zif / 268 gene expression , reaching the maximal level at 30 60 minutes for zif / 268 and at 60 minutes for the other genes . ^^^ Different glutamate receptor agonists , such as NMDA , kainate , quisqualate , trans ( + / ) 1 aminocyclopentane 1 , 3 dicarboxylic acid ( t ACPD ) and alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate ( AMPA ) were able to increase c fos , c jun , and zif 268 mRNA levels with rapid and transient kinetics similar to those observed after glutamate treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of differentiation of F 9 teratocarcinoma stem cells by retinoic acid and cAMP has been shown to involve the activation of the transcription factor AP 1 ( a heterodimer of the proto oncogene products c Fos and c Jun ) ; moreover , stable expression of either Fos or Jun drives F 9 cells into differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the possibility that specific growth factors and / or proto oncogenes are expressed differentially , we measured mRNA levels of transforming growth factors beta 1 ( TGF beta 1 ) , TGF beta 2 and TGF beta 3 and of the c fos and c jun oncogenes by Northern blotting in normal prostate , benign prostatic hyperplasia ( BPH ) and prostate cancer . ^^^ Expression of c fos followed the TGF beta 1 pattern , whereas no difference could be seen in c jun expression in cancer as compared with BPH and normal prostate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis and transient transfection experiments with chloramphenicol acetyltransferase constructs of oncogene promoter regions demonstrated significant increases over control ( 0 . 5 % fetal calf serum ) in c myc , c jun , and c fos mRNA levels and expression in cells treated with 0 . 1 nM 12 ( R ) HETrE . ^^^ Since the protooncogenes ( c fos , c jun , and c myc ) are immediate early response genes that are implicated in the process of cell proliferation and differentiation , and activation of certain transcription factors , in particular NF kappa B , is associated with the immediate response of the cell to an injury , we propose that 12 ( R ) HETrE ' s mitogenic and angiogenic activities are mediated , in part , via the activation of NF kappa B and expression of these protooncogenes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transient transfections with a CAT fusion gene driven by an AP 1 cis element demonstrated that although PGE 2 markedly induced c fos , PGE 2 did not increase AP 1 driven transcriptional responses . ^^^ Regulation of gene transcription by PGE 2 probably involves c fos induction without concomitant activation of AP 1 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nodularin up regulated induction of c jun , jun B , jun D , c fos , fos B , and fra 1 mRNA transcripts in rat liver after i . p . administration , and the accumulation of the mRNA transcripts was sustained for over 9 h after treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we found that calphostin C induced c fos and c jun mRNA accumulation in the lung adenocarcinoma cell line A 549 in a light dependent manner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of neuronal NOS , c jun and c fos in spinal motoneurons following axonal damage were investigated in the present study . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the other hand , Y821F substitution impaired proliferation and survival without affecting PI 3 kinase , p21ras and MAPK activation , and induction of c myc , c myb , c fos and c jun mRNA , while KL induced cell adhesion to fibronectin remained intact . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Static stretch caused significant adaptive growth , with increases in c fos , c jun , and insulin like growth factor 1 ( IGF 1 ; 12 fold ) mRNA levels , and protein ( 19 % ) , RNA ( 128 % ) , and DNA ( 45 % ) contents . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of C FOS , C JUN and phosphotyrosine gene products in lung cancer ] . ^^^ An immunohistochemical study on C FOS , C JUN and phosphotyrosine ( P Tyr ) cancer gene products was performed . ^^^ The simultaneous positive expression of C FOS and C JUN was 56 % ( 54 cases ) . ^^^ Negative C FOS and positive C JUN was 32 % . ^^^ Positive C FOS and negative C JUN was less than 4 % ( 4 cases ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study was conducted to detect abnormal levels of several proto oncogenes ( c jun , c fos , c H ras ) and of the p 53 and the alpha fetoprotein gene in the liver during cirrhosis , a pathological process which predisposes to the development of hepatocarcinoma . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 1 beta was found to evoke an early , preferential release of beta lipotropin ( beta LPH ) which was accompanied by elevations in POMC heteronuclear ( hn ) RNA and c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells ; p 21 ras , p 39 c jun , p 55 c fos , aldehyde dehydrogenase ( ALDH ) , glutathione s transferase ( GST p ) , and alpha fetoprotein ( AFP ) during DCA induced hepatocarcinogenesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We performed experiments to determine the effects of ionizing radiation exposure on expression of genes such as beta actin , c fos , histone H 4 , c myc , c jun , Rb , and p 53 after exposure of Syrian hamster embryo ( SHE ) cells to the protein synthesis inhibitor cycloheximide . ^^^ The results revealed that when ionizing radiation ( either fission spectrum neutrons or gamma rays ) was administered 15 min after cycloheximide treatment of SHE cells , the radiation exposure reduced cycloheximide mediated gene induction of c fos , histone H 4 , and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We measured DNA , RNA , and protein content , number of nuclei per tubular section , as well as c fos , c jun , c myc , c H ras , c sis , and c erb B 2 protooncogene expression in kidneys taken at time of surgery and 2 , 7 , and 14 days after sham operation ( control rats ) , Uni , or Nx . ^^^ The protooncogene mRNA expression was constantly absent in control and Uni rats , whereas that of c fos and c jun genes was detected in Nx rats at day 14 with a 2 to 12 fold increment . ^^^ The c fos and c jun protein levels were also increased at that time in Nx rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun expression by TPA was inhibited by both herbimycin A and calphostin C , suggesting that both PKC and TK pathways are necessary for the induction of the TPA induced transcription factor AP 1 , which is a known TPA inducible early immediate gene product . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system : activation of Raf 1 leads to hypermodification of c jun and c fos via multiple pathways . ^^^ We have used this system to coexpress different combinations of the critical signaling proteins pp60v src , p21v ras , Raf 1 and ERK 1 and assayed the effects of resulting signaling cascades on the modifications of coexpressed transcription factors c jun or c fos . ^^^ Activation of this ERK 1 independent pathway together with the ERK 1 dependent pathway that modifies c jun results in additional modification of c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Additionally , HGF induced increased transcription of c fos , c jun , junB , junD , and c myc early response genes in both cell lines . ^^^ We therefore suggest that the second messenger proteins PI3K , GAP and NCK , and possibly the protein products of the c fos , c jun , junB , junD and c myc genes , are important elements in the HGF induced mitogenic pathway in the normal mouse epithelial cell lines M 23 and MM55 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The defect in the expression of these early activation genes was selective in that induction by mitogens of mRNA encoding other early activation gene products such as c fos and c jun was not impaired . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NFAB contains the tissue restricted Ets protein Elf 1 and the AP 1 factors Jun B and c Fos , which bind to a novel 3 ' enhancer ETS AP 1 motif . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In electrophoretic mobility shift assays using nuclear extracts from cultured cells and primary tissues , several AP 1 proteins ( c Jun , JunB , JunD , and c Fos ) bound the cyclin D 1 954 region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further investigations using supershift and shift Western analysis showed that c Fos and JunB bind to the AP 1 element during hypoxia and that these protein levels are stimulated by hypoxia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Degradation of c Fos by the 26S proteasome is accelerated by c Jun and multiple protein kinases . c Fos is associated with c Jun to increase the transcription of a number of target genes and is a nuclear proto oncoprotein with a very short half life . ^^^ Coexpression of c Fos and c Jun in HeLa cells caused marked increase in the instability of c Fos , whereas 5 Fos , the retroviral counterpart of c Fos , was stable irrespective of the coexpression of c Jun . ^^^ Interestingly , deletion of the C terminal PEST region of c Fos , which is altered in 5 Fos by a frameshift mutation , greatly enhanced its stability , with loss of the effect of c Jun on its stability . c Fos synthesized in vitro was degraded by the 26S proteasome in a ubiquitin dependent fashion . ^^^ Simple association with c Jun had no effect on the degradation of c Fos , but the additions of three protein kinases , mitogen activated protein kinase , casein kinase 2 , and CDC 2 kinase , resulted in marked acceleration of its degradation by the proteasome ubiquitin system , though only in the presence of c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study the time course of induction of c jun , jun B and zif 268 mRNA by kainate was characterized in rat cerebral cortex and compared to that of c fos mRNA induction . ^^^ These results show that a time dependent and co ordinated induction of c fos , c jun , jun B and zif 268 mRNA in cerebral cortex occurs in response to the persistent excitation caused by excitotoxin injection which is mediated by glutamate and shows a differential sensitivity to dexamethasone . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While a large body of literature describes the induction of immediate early genes , including c fos , fosB , c jun , junB , zif / 268 , and krox genes by glutamate and agonists in neurons , very little is known about preexisting transcription factors controlling the induction of such genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In other cases either a decrease ( XP A ) or no change ( XP D ) in URE binding activities was noticed , which may be associated with decreased c fos and poor c jun expression after UV irradiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the p 53 protein ( p 53 ) was compared with those of several oncogenes including c fos ( Fos ) , c jun ( Jun ) , and epidermal growth factor receptor ( EGFR 1 ) using immunohistochemistry in frozen and paraffin embedded sections of 25 basal cell carcinomas ( BCCs ) to find out any correlation between p 53 and oncogenes in the pathogenesis of human BCC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 3 ( IL 3 ) or granulocyte macrophage colony stimulating factor ( GM CSF ) activates c fos , c jun , and c myc genes and proliferation in both hematopoietic and nonhematopoietic cells . ^^^ Using a series of deletion mutants of the beta subunit of human GM CSF receptor ( hGMR ) and inhibitors of tyrosine kinase , two distinct signaling pathways , one for activation of c fos and c jun genes , and the other for cell proliferation and activation of c myc gene have been elucidated . ^^^ In contrast to wealth of information on the pathway leading to activation of c fos / c jun genes , knowledge of the latter is scanty . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In fact , expression of integrin alpha 5 beta 1 on these cells induces the transcription of growth arrest specific gene 1 ( gas 1 ) , a gene product known to induce cellular quiescence , but blocks transcription of the immediate early genes c fos , c jun , and jun B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Decrease of zif 268 and c fos and increase of c jun mRNA in the cat areas 17 , 18 and 19 following complete visual deafferentation . ^^^ These results suggest that visual input activates zif 268 and c fos expression and tonically depresses c jun expression in the primary visual complex yielding similar levels of c jun and c fos expression in normal conditions . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Genes such as bcl 2 and bax have been implicated in the direct control of cell death , while cellular immediate early genes ( cIEGs ) , such as c fos and c jun have been repeatedly associated with neuronal degeneration . ^^^ We have generated fos lacZ and jun lacZ transgenic mice that can be used to assess expression of c fos and c jun following these various manipulations . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The addition of c Jun and c Fos antibodies produced strong supershifts of the complex generated by COS 1 extract , but very weak supershifts of the complex formed by BEN extract . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vivo effects of adrenocorticotropin on c jun , jun B , c fos and fos B in rat adrenal . ^^^ We have studied the in vivo effects of adrenocorticotropin ( ACTH ) on mRNA levels of c jun , jun B , c fos and fos B , in rat adrenals . ^^^ Although less abundant than c jun , the mRNA of jun B could be detected in both zones , whereas that of c fos could barely be detected and that of fos B could not . ^^^ After an injection with short acting ACTH , mRNA levels of c jun , c fos , jun B and fos B were maximally increased in both zones within 30 min . ^^^ Within 5h , the mRNA levels decreased towards control levels for c jun , to below control levels for jun B , and to undetectable levels for c fos and fos B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunocytochemistry was performed on vibratome sections with specific polyclonal antisera directed against c FOS , FOS B , c JUN , JUN B , JUN D , KROX 24 , and KROX 20 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased DNA binding activity of AP 1 was detected after only 1 3 min , was maximal after 6 hr , and remained elevated at 12 24 hr . c Fos was found to be a component of the AP 1 complex . ^^^ Since the increase in AP 1 binding activity preceded the increase in c fos mRNA , posttranslational modifications may be important in mediating the early SPC induced increases in AP 1 DNA binding activity . ^^^ Western analysis detected increases in nuclear c Jun and c Fos proteins following SPC treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased c fos , c jun , C / EBP beta , and C / EBP delta mRNA expression was correlated with increased DNA binding activity of the transcription factor complexes activator protein 1 and C / EBP in tissue lysates . ^^^ We show that in addition to the antioxidant enzyme manganese superoxide dismutase , expression of a variety of stress responsive genes including heme oxygenase 1 , c fos , c jun , CAAT enhancer binding protein ( C / EBP ) beta , and C / EBP delta were increased after hyperoxia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Importantly , the increase in AP 1 activity was not due to increased expression of either c fos or c jun , as evidenced by the steady state mRNA levels of both genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
X / XO induced c myc and c fos expression in JB 6 cells , with c fos induction being more pronounced in P cells , whereas a biphasic increase in c jun was seen in P+ cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The observation that the overexpression of c fos and c jun in the cells results in a clear augmentation of the effects of pX on TRE directed transcription and the induction of the DNA binding activity of c jun / c fos heterodimers by AP 1 depleted nuclear extracts from pX expressing cells strongly supports the involvement of post translational modifications . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Curcumin , a specific inhibitor of c jun / AP 1 , inhibited the cytokine induced c jun gene expression in a dose dependent manner , though the c fos gene expression was not affected . ^^^ TGF beta 1 induced expression of both early proto oncogenes c fos and c jun in the cells was also inhibited by H 7 and staurosporine . ^^^ Antisense oligonucleotides to c fos and c jun genes inhibited significantly the cytokine induced JE / MCP 1 gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition a novel role of triiodothyronine as inhibitor of growth factor induced transcriptional expression of regulatory genes ( c fos , c jun ) is suggested . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c fos promoter is characterized by photofootprints at the serum response element ( SRE ) , at the adjacent binding site for ternary complex factor ( TCF ) , at an AP 1 site and at a binding site for a growth factor inducible protein ( SIF ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oncoproteins c fos , c jun , c ets 1 , c myc L and L myc were identified in the tumour and surrounding tissue . ^^^ Expression of c fos was revealed in 79 of 138 ( 59 . 4 % ) of proliferative and dysplastic changes of lung epithelium ; c jun in 40 of 61 ( 65 . 6 % ) , c ets 1 in 22 of 41 ( 53 . 7 % ) , c myc in 41 of 96 ( 42 . 7 % ) and L myc in 15 of 61 ( 24 . 6 % ) , mainly in altered bronchial epithelium with a positive reaction to the antibodies against neuron specific enolase and S 100 protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Together with our previous report that c fos was expressed transiently in the INL and the GCL after the onset of the light period and constitutively in the ONL throughout the dark period , the colocalization of c fos with c jun , jun B and jun D in the INL and the GCL after light onset and with jun D in the ONL during the dark period suggests that Jun and Fos proteins form an active AP 1 transcription factor which plays a key role in gene regulation in retinal cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NFIL 5P complex was inhibited in the presence of an excess NF AT and AP 1 oligonucleotides and super shifted by antisera raised against NF ATp , c Fos , and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In serum stimulated cells , SRTX C reduced c jun mRNA expression by 50 % whereas c fos or krox 24 mRNA expression were not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We performed Northern blot analysis to study the expression of c jun , c fos , and c myc mRNAs during MI using 1 mM NaCN and 20 mM 2 deoxy d glucose , and also during the recovery from MI of 30 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Basal expression of the inducible transcription factors c Jun , JunB , JunD , c Fos , FosB , and Krox 24 in the adult rat brain . ^^^ The expression of c Jun , JunB , JunD , c Fos , FosB , and Krox 24 was investigated in the brain of untreated male Sprague Dawley and female BDIX rats by immunocytochemistry using specific antibodies . ^^^ JunD was expressed at high levels in those areas that also exhibit c Jun , JunB , c Fos , and FosB IR , such as locus coeruleus , periolivary nuclei ( ncl . ) , pontine and central gray , lateral lemniscal ncl . , inferior and superior colliculi , leaflet of geniculate ncl . , midline nuclei of thalamus , dorsomedial and paraventricular ncl . of hypothalamus , ncl . supraopticus , dorsolateral part of caudate putamen and lateral septal ncl . ^^^ In contrast to the high number of JunD positive neurons , c Jun , JunB , c Fos , and FosB proteins were detected in rather low numbers of neurons in these brain areas ; the rank of the number of immunopositive neurons was c Fos > JunB > c Jun > FosB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of cultured cerebellar granule cells with N methyl D aspartate ( NMDA ) or kainic acid ( KA ) leads to activation of activator protein 1 ( AP 1 ) DNA binding activity , which can be monitored by an increase in 12 O tetradecanoylphorbol 13 acetate ( TPA ) responsive element ( TRE ) binding activity , in concert with c fos induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Senescent cells showed the strong transcriptional repressions of early serum responsive genes ( c fos , c jun , c myc ) , late responsive genes of transcription factor E2F1 and cyclin E . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neither cyclic AMP response element binding protein nor c fos antisense oligonucleotide injection reduced c Jun immunostaining in the striatum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of c jun and c fos mRNA expression lasted longer in the LM2GR cells treated with ssFBS ; however , the maximal induction was greater in the LM 2 cells treated with FBS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this cell line , a transient suppression of HPV transcripts was observed at 5 h , whereas in differentiation resistant , carcinoma derived lines , TPA had little effect on HPV oncogene expression . c myc transcripts were suppressed for the duration of exposure to TPA in only the differentiation competent cells ; c fos and c jun were transiently induced in all cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The membrane proximal proline rich sequence of the cytoplasmic domain of IL 5R alpha , which is conserved among the alpha chains of IL 5R , IL 3R , and GM CSF receptor ( GM CSFR ) , was found to be essential for the IL 5 induced proliferative response , expression of nuclear proto oncogenes such as c jun , c fos , and c myc , and tyrosine phosphorylation of cellular proteins including JAK 2 protein tyrosine kinase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report that heterodimerization with c Fos does not increase the binding of c Jun to the uPA 5 ' TRE , in contrast to the increased binding at a consensus AP 1 site . ^^^ Our data further suggest that c Fos can act as a repressor of the c Jun / ATF 2 binding site , revealing an important functional difference , with respect to canonical AP 1 elements . . ^^^ Heterodimerization of c Jun with ATF 2 and c Fos is required for positive and negative regulation of the human urokinase enhancer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The pattern of induction of the early immediate response genes c fos and c jun observed during oxidative stress differs from that found in post ischaemic reperfused livers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Corroborating these observations , expression of the downstream oncogenes c jun and c fos was also dramatically reduced during the first 4 h of treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increase in messenger ribonucleic acid encoding the myometrial gap junction protein , connexin 43 , requires protein synthesis and is associated with increased expression of the activator protein 1 , c fos . ^^^ Moreover , the temporal correlation between the expression of c fos and Cx 43 and the presence of AP 1 cis acting elements within the Cx 43 promoter suggest that c fos may be one of these trans activating proteins . . ^^^ Estrogen treatment alone induced an increase in mRNA encoding c fos and c jun in nonpregnant rats , which preceded by 2 3 h an increase in Cx 43 mRNA . ^^^ Labor was also associated with a coincident expression of c fos and Cx 43 in the myometrium , although there was no change in c jun mRNA levels during this period . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have reported previously that the widespread inhibitory actions of somatostatin might be mediated by its ability to inhibit the expression of the immediate early genes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study we investigated the expression of the immediate early genes ( IEGs ) c fos , c jun , and junD on mRNA and protein levels during the spermatogenic cycle of the rat using Northern blotting , in situ hybridization , and immunocytochemistry . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Linoleic acid and its metabolites , hydroperoxyoctadecadienoic acids , stimulate c Fos , c Jun , and c Myc mRNA expression , mitogen activated protein kinase activation , and growth in rat aortic smooth muscle cells . ^^^ Linoleic acid induces DNA synthesis , c fos , c jun , and c myc mRNA expression and MAPK activation in VSMC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EGF led to dramatic increases in c fos ( greater than 20 fold ) , c jun ( 2 fold ) , and jun B ( 3 fold ) gene expression at 30 minutes , consistent with the previously characterized immediate early gene response in IEC 6 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Knowing that apoptosis is associated with changes in the expression of primary response genes , we have measured c fos , zif / 268 , and c jun mRNA levels during maturation of cultured granule cells grown in 10 or 25 mM K+ . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
VP 16 treatment significantly inhibited c myc expression and induced c jun and c fos expressions in sensitive cells . ^^^ In contrast , VP 16 had no effect on c myc , c jun or c fos expressions in resistant cells . ^^^ The level of bcl 2 oncogene was similar in both cell lines ; however , treatment with VP 16 resulted in a time and dose dependent degradation of the genomic DNA into oligo sized DNA only in the sensitive cells , indicating that differential expressions of oncogenes ( c myc , c jun , and c fos ) and susceptibility to apoptosis may play important roles in the sensitivity and resistance to VP 16 in HL 60 cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Deletion of a conserved juxtamembrane sequence ( KFG ) in the Trk NGF receptor resulted in impaired neurite outgrowth , somatic hypertrophy , and induction of c fos , c jun , and TIS 1 immediate early genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have demonstrated a rapid and reversible induction of ODC ( mRNA and activity ) , as previously reported for the mRNA expression of other `` early ' ' genes , c fos , c jun , and c myc , in the same experimental model . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos is assumed to be involved in the transduction of external signals to the nucleus as a component of AP 1 transcription factor , a protein complex that contains a member of the jun proto oncogene family . ^^^ Finally , considering the fact that second long lasting phase of proto oncogene expression was found associated with increased PRL mRNA accumulation whatever the stimulus , it might be proposed that AP 1 [ c Fos / Jun B ] factor could be involved in the regulation of PRL gene expression . ^^^ Stimulation of C fos and jun B proto oncogenes : potential role of TRH effects in clone cell line with prolactin ( GH3B6 ) ] . ^^^ We have thus looked for the member ( s ) of the jun family that could be the partner of c fos in TRH stimulated GH3B6 cells . ^^^ The common biphasic pattern of jun B and c fos mRNA regulation under TRH exposure , i . e . , an early peak and a long lasting plateau phase , suggested that jun B was the best candidate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RNA blots of total cellular RNA isolated from quiescent and endothelin ( ET 1 ) stimulated normal rat kidney ( NRK ) cells demonstrated that ET 1 induced the expression of c jun , jun B , and c fos mRNA in a time dependent manner with maximal expression of mRNA by 1 hr after the addition of ET 1 . ^^^ The expression of c jun , jun B , and c fos mRNA was inhibited by the endothelin type A receptor ( ET ) selective antagonist , BQ 123 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 consensus sequences ( TGAGTCA ) are the major 12 O tetradecanoylphorbol 113 acetate ( TPA ) responsive elements shared by several TPA inducible genes , such as c sis , c fos , c myc , collagenase , stromelysin , hMTIIA and SV 40 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel retardation assays and cotransfection experiments with c fos and c jun expression vectors suggested that members of the Fos and Jun families bind to the AP 1 like element of FER 1 and contribute to its regulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both of the activator protein 1 elements can bind a complex containing c fos / c fos related antigen proteins and the adjacent E box element is specifically recognized by proteins present in HeLa nuclear extract . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , it was observed that doses in the range of 0 . 25 2 . 0 Gy induced different amounts of the mRNAs of the proto oncogenes c fos , c jun , c myc and c Ha ras at a given dose and time in Epstein Barr virus transformed human lymphoblastoid 244B cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We further analyzed the activity of c fos , c jun , c myb and nm 23 which are described to be involved in c myc transcriptional activation , c jun and c fos were not constitutively activated and can be excluded as regulators . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among the genes implicated in the regulation of this phenomenon are the immediate early genes such as c fos and c jun , whose expression is modulated by a complement of preexisting transcription factors . ^^^ Indeed , cotreatment of thymocytes with the nonspecific serine protease inhibitor phenylmethylsulphonyl fluoride was able to partially protect the stability of the DNA binding proteins and alter the expression of the c fos and c jun genes but did not inhibit apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunocytochemical investigation also confirmed that heparin could inhibit the expression of nuclear oncogene c fos and c jun in the MsC stimulated by PMA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The low c Fos expression in the female NOD thymocytes was most prominent in CD3low thymocytes . c Jun expression of the CD3low thymocytes was also lower in the female NOD mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The developmental change of APEX gene expression was not necessarily associated with the changes of expression of c fos and c jun genes measured by northern blot hybridization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The kinase inserts blocked the ability of TrkC to mediate neurotrophin 3 stimulated c myc and c fos transcription and activation of the AP 1 transcriptional complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun gene products and heat shock protein after brief and prolonged cerebral ischemia in gerbils . ^^^ We compared the extent of insults and induction of c fos and c jun gene products ( c FOS and c JUN ) as well as HSP in ischemic and postischemic gerbil brains immunohistochemically . ^^^ Antibodies for c FOS , c JUN , and HSP 70 were used for immunohistochemistry , and positive reactions were semiquantitatively analyzed . ^^^ RESULTS : After ischemia for 15 minutes and reperfusion , c FOS was induced promptly after 1 to 6 hours in pyramidal cells of the CA 3 and CA 4 regions , while c JUN became visible in the same areas after recirculation for 4 to 48 hours . ^^^ In layers 1 and 2 of the cerebral cortex , c FOS and c JUN peaked at 3 hours and HSP 70 at 96 hours . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
FKBP 59 gene activation in CCL 39 fibroblasts requires protein synthesis during the first 2 h of stimulation , a period of time during which proto oncogenes such as c fos or c jun are expressed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since some of the new proteins could be nuclear transcription or transacting factors , we investigated the effects of hCG on cyclic AMP response element binding protein ( CREB ) , c Fos and c Jun protein levels . ^^^ Treatment of GT 1 7 neurons with hCG resulted in an increase of 43 kDa phosphorylated CREB , 50 kDa c Fos and 40 kDa c Jun proteins compared to the corresponding controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Post ischemic expression of c FOS , FOS B , c JUN , JUN B , JUN D and KROX 24 was investigated by in situ hybridization and immunocytochemistry up to 48 h of recirculation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cells en route to apoptosis are characterized by the upregulation of c fos , c myc , c jun , cdc 2 , and RB phosphorylation , resembling events of early cell cycle traverse . ^^^ Investigating the regulation of early cell cycle genes during this process , we found that c myc , c jun , c fos , and cdc 2 protein presence is induced after serum deprivation , when the phosphorylated form of the RB protein also appears . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The level of transcripts for c jun , c fos , c myc , and transforming growth factor beta 1 were increased for an extended period of time in livers of deficient animals , whereas the expression of both p 53 and max were unchanged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In undifferentiated Tera 2 cells FGF stimulation caused an increase of c fos mRNA , and c jun mRNAs , but no increase of junB mRNA , whereas in the differentiated cells , FGFs strongly stimulated the expression of all three genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We now report that in both quiescent and non quiescent mouse bone marrow derived cultured mast cells ( BMCMC ) rrSCF 164 induces increased mRNA levels for the `` early response genes ' ' c fos , c jun and junB but has only slight effects on the expression of junD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Some immediate early genes ( such as c fos , c jun or jun B ) are known to encode transcription factors that bind to DNA at sites that regulate gene expression and they could therefore contribute to long term changes in motoneurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , ACE inhibitors and Ca ( 2+ ) channel blockers inhibited platelet derived growth factor BB induced transcription of c fos and c jun genes . ^^^ The findings suggest that increased de novo synthesis of mRNA low density lipoprotein receptor apparently involves the participation of delta and epsilon isoforms of protein kinase C and transcription factors c Fos and c Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study demonstrates that the alpha beta gamma heterotrimer and beta gamma heterodimer complexes of IL 2 receptor reconstituted on murine fibroblast L 929 cells can transduce IL 2 mediated signals for activation of tyrosine kinase and for induction of c myc , c fos , and c jun expression . ^^^ Another mutant , with a C terminal deletion of 30 amino acids , retained the ability to activate a tyrosine kinase and to induce c myc expression but lost the ability to induce c fos and c jun expression . ^^^ These results suggest that at least two distinct signals , one for c myc induction , which parallels tyrosine kinase activation , and the other for c fos and c jun induction , can be transduced from the IL 2 receptor complexes reconstituted on fibroblastoid cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
FK 506 and CsA also reduced expression of the proto oncogenes , c myc and c fos , but not c jun and interleukin 2 receptor alpha ( IL 2R alpha ) gene in H 109 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , herbimycin A attenuated c fos induction , AP 1 DNA binding , and transcription directed by an AP 1 cis element in response to ET 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RNAs from several brain regions were analyzed by Northern blot hybridization for their relative concentrations of nine IEG mRNAs ( c fos , c jun , junB , TIS 1 ( nur 77 ) , TIS 7 , TIS 8 ( zif 268 ) , TIS 10 , TIS 11 , and TIS 21 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Suppression of the growth factor mediated induction of c fos and down modulation of AP 1 binding activity are not required for cellular senescence . ^^^ It has been suggested that the impaired response of the c fos gene to serum growth factors and the concomitant loss of AP 1 activity may be a crucial step in the process of cellular senescence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ability of c Fos and c Jun proteins to interact directly with the TATA box binding protein ( TBP ) , the general transcription factor required for initiating the assembly of transcription complexes , was investigated . ^^^ Using co immunoprecipitation and protein protein association assays , we show that both c Fos and c Jun bind specifically and stably to TBP . ^^^ Mutational analysis demonstrates that both the basic region and leucine zipper domains of c Fos and c Jun are necessary and sufficient for stable association with TBP . ^^^ A 51 residue region from the conserved C terminal region of TBP , previously shown to be the binding site for the viral activator protein E1A , interacts with c Fos and c Jun proteins . ^^^ We propose that c Fos and c Jun proteins function as transcriptional activators , in part by recruiting TBP to form complexes to initiate RNA synthesis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos , c jun and c myc mRNA accumulated on Northern blots between 4 12 h of inflammation and the steady state level of two small alpha fetoprotein transcripts characteristic of the adult liver increased at 4 h and 24 h of inflammation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of p 210 bcr abl dependent tyrosine phosphorylation resulted in a reduction of active p21RAS GTP complexes in the transformed cells , in diminished expression of the nuclear early response genes c jun and c fos , and in lower cellular proliferation rate . ^^^ However , expression of c fos and c jun nuclear proto oncogenes were strongly inhibited and p 21 RAS activity was downregulated . ^^^ Furthermore , p 21 RAS activity is linked to pathways that regulate c jun and c fos expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In these areas , expression of the transcription factor proteins c JUN , JUN B , JUN D , c FOS , FOS B , KROX 20 , KROX 24 , and CREB was investigated by immunocytochemistry up to 150 d . ^^^ JUN B , c FOS , FOS B , and KROX 20 were not expressed in these areas , and substantial alterations of CREB immunoreactivity ( CREB IR ) could not be detected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously demonstrated a correlation between the kinetics of activation of the nuclear oncogenes c fos , c jun and c myc and the alpha fetoprotein ( AFP ) gene in adult rat hepatocytes proliferating in culture , which led us to raise the hypothesis of a possible regulation of the AFP gene by nuclear oncogenes . ^^^ In this study we have searched for a possible correlation between the basal level of AFP gene expression , by several hepatoma cell lines that express the AFP gene differently , and the basal level of expression of the nuclear oncogenes c fos , c jun and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This may suggest a role for active transcriptional complexes such as AP 1 ( c Fos / Jun B ) , which could be formed following conjoint inputs to Purkinje cells and which may help to establish cerebellar long term plasticity . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Lack of correlated expression between the glutathione S transferase P form and the oncogene products c Jun and c Fos in rat tissues and preneoplastic hepatic foci . ^^^ Since the expression of glutathione S transferase P form ( GST P ) has been suggested from in vitro studies to be partly regulated by the oncogene product , c Jun and c Fos , their distributions were compared in normal rat tissues and preneoplastic hepatic lesions induced by the Solt Farber protocol . ^^^ Immunohistochemically demonstrated GST P protein was positively correlated with expression of both c Jun and c Fos in the epidermis of the skin and the smooth muscle of adult lung and with either c Jun or c Fos respectively in the bile ducts and bronchial epithelium . ^^^ However , GST P expression was also observed in proximal and distal straight segments of the kidney and other tissues negative for c Jun and c Fos and both c Jun and c Fos were present in the renal proximal and distal convoluted tubules , where GST P was lacking . ^^^ Thus , the localization of GST P was in some cases clearly separable from those of c Jun or c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The pattern and time course of brain activation in response to acute swim and restraint stress were examined in the rat by in situ hybridization using complementary RNA probes specific for transcripts encoding the products of the immediate early genes c fos , c jun and zif / 268 . ^^^ Few brain areas showed increased expression of c jun following stress ; these regions also showed induction of c fos and / or zif / 268 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have used this vector to demonstrate the formation in vivo of complexes between the transcription factor ATFa , a member of the family of ATF / CRE binding proteins , and the c Jun or c Fos proteins . ^^^ Such interactions could be detected in crude extracts from cells transfected with vectors expressing the GST ATFa fusion protein , as well as the c Jun or c Fos proteins . ^^^ Complexes containing both ATFa and either c Jun or c Fos were specifically retained on glutathione ( GSH ) agarose beads as revealed by immunoblot analyses . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c Fos and c Jun in the cornea , lens , and retina after ultraviolet irradiation of the rat eye and effects of topical antisense oligodeoxynucleotides . ^^^ AIMS Immunohistochemical techniques were used to investigate c Fos and c Jun proto oncogene expression in the cornea , lens , and retina after ultraviolet irradiation of the rat eye . ^^^ Animals were perfused 1 , 6 , or 24 hours after irradiation and tissue sections were incubated with specific antiserum to c Fos and c Jun , respectively . ^^^ RESULTS Non irradiated contralateral eyes displayed no c Fos and c Jun immunoreactivity . ^^^ One and 6 hours after ultraviolet exposure numerous c Fos and c Jun immunopositive nuclei were observed mainly in the epithelial cell layers of the cornea and the lens epithelium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In preliminary studies , we have found that exposure of cells to hypoxia rapidly induces the expression of several immediate early genes , including c jun , jun D , and c fos , and of a bifunctional redox protein / endonuclease , Ref 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The GRE at nucleotide 7640 is a composite GRE ( cGRE ) containing an overlapping activator protein 1 ( AP 1 ) motif for the c jun homodimer and c jun / c fos heterodimer . ^^^ This report examined the effects of c jun and / or c fos AP 1 protooncogenes and the glucocorticoid hormone dexamethasone on expression of the HPV 16 cGRE in AP 1 deficient P 19 embryonal carcinoma cells . ^^^ The results reveal a unique cross talk between the distinct AP 1 and hormone signaling pathways , suggesting the involvement of a complex interaction of c jun and c fos and glucocorticoid hormone receptor with the HPV 16 cGRE , resulting in novel control patterns for regulating viral expression . . ^^^ Differential regulation by c jun and c fos protooncogenes of hormone response from composite glucocorticoid response element in human papilloma virus type 16 regulatory region . ^^^ For the c jun / c fos heterodimer , the response to hormone was progressively diminished . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the proto oncogenes , c fos and c jun , are expressed during GC mitosis , studies were undertaken to determine whether or not the expression of these two proto oncogenes products was enhanced by insulin . ^^^ The expression of c fos and c jun proteins was assessed by immunocytochemistry . ^^^ These studies showed that after 5 h , insulin increased the percentage of cells that stained for c fos and c jun by 15 + / 2 % and 19 + / 4 , respectively ( p < 0 . 05 ) . ^^^ Both progesterone and 8 br cAMP , which block insulin dependent GC mitosis , also inhibited the expression of c fos and c jun . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of dexamethasone on cytokine and phorbol ester stimulated c Fos and c Jun DNA binding and gene expression in human lung . ^^^ Dexamethasone modulated the expression of both c jun and c fos mRNA and produced long term ( 24 h ) 40 % reduction in both mRNAs when compared to control tissues . ^^^ PMA induced a rapid and prolonged increase in c Fos and c Jun nuclear localization , which was not attenuated by co incubation with dexamethasone . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This allowed analysis of the expression of functional glutamate receptor subtypes , examination of their role in controlling intracellular free calcium ( [ Ca2+ ] 1 ) , and determination of their relative contributions to the transcriptional regulation of six immediate early genes c fos , fosB , c jun , junB , zif / 268 ( also termed Egr 1 ; NGFI A ; Krox 24 ) and nur / 77 ( also termed NGFI B ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest the possibility of different interactions of the c fos , jun B and c jun gene products throughout a 24 h period in discrete brain regions . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ANP gene transcription is activated by c jun and is generally suppressed by c fos . ^^^ In the present study , fra 1 , a close relative of the c fos gene product in terms of its structure and functional activity , behaved like fos in cardiac atriocytes , effecting an approximately 50 % reduction in c jun activatable expression of a human ANP chloramphenicol acetyltransferase ( CAT ) reporter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Coupled with reports of estrogen response elements in c fos and estrogenic induction of c fos and c jun in vivo , these findings also support a role for AP 1 components as early response genes in estrogen induced proliferation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using cytoplasmic deletion mutants of the human GM CSF receptor ( hGMR ) beta subunit and tyrosine kinase inhibitors , we previously showed that distinct signaling pathways of hGMR are involved in the induction of c fos / c jun mRNAs and of c myc mRNA / cell proliferation . ^^^ In contrast , a more distal region which is essential for activation of c fos and c jun genes is required for the PEA3 / PEBP5 dependent transcription of Py early promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to dissect the molecular mechanisms of action of TGF beta on osteoblasts , the effects of TGF beta on the steady state mRNA levels of c fos , c jun , and jun B proto oncogenes on normal human osteoblast like cells ( hOB ) and a transformed human osteoblast cell line ( MG 63 ) were measured . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of quiescent SMCs to 30 microM BaP inhibited the ability of serum to induce c fos mRNA expression and decreased AP 1 binding to a 12 O tetradecanoyl phorbol 13 acetate responsive element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interestingly , growth inhibition correlates with an altered expression pattern of early serum response genes ; c Jun mRNA and c Fos protein levels are elevated in Abl blocked cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Serum response factor ( SRF ) , which can bind to the sm alpha actin SREs , restores alpha actin promoter activity in ras transformed cells . c Fos , c Jun and YY 1 also repress alpha actin promoter through SREs , suggesting that these transcription factors may play a role in repressing alpha actin promoter in ras transformed cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Augmentation of c fos and c jun expression in transgenic mice carrying the human T cell leukemia virus type 1 tax gene . ^^^ We found that the expression of the c fos and c jun genes , but not of the lyn and c myc genes , was augmented 2 to 20 fold in histologically normal skin and muscle of these mice . ^^^ The c fos and c jun genes were also activated in these tumors . ^^^ The possible roles of elevated c fos and c jun gene expression in tumorigensis are discussed . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In our study , we determined the trans activating properties of nuclear proto oncogene proteins c Fos , c Jun and c Myc on P 97 enhancer / promoter activity of HPV 16 . ^^^ Using a CAT reporter construct containing the HPV 16 enhancer / promoter element , we investigated the trans activating effects of c Fos , c Jun , c Myc , and E 2 in cervical HT 3 cells . c Fos and c Jun overexpression resulted in a 3 . 3 and 3 . 1 fold up regulation of CAT activity . ^^^ Based on these findings , we investigated the expression of HPV DNA ( 16 and 18 ) as well as nuclear proto oncogenes ( c fos , c jun and c myc ) in nine cervical cancers by in situ hybridisation . ^^^ All tumours showed an intense and homogeneous expression of c fos and c jun mRNA , while the signal for c myc was detectable only in four specimens . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although early responsive genes like NGFI A and c fos are induced in both cell types upon NGF treatment , the induction of c jun expression is restricted to PC 12 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : Immunoblot analysis using antibodies to retinoblastoma , statin , c Fos , c Jun , and Cdc 2 proteins was used for our study on the expression of early cell cycle genes in carcinoma and its adjacent mucosa . ^^^ RESULTS : We found upregulation of c Fos , c Jun , and Cdc 2 expression in carcinoma and adjacent mucosa up to 4 cm from the edge of the carcinoma . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of the early response genes , JE , which is induced by competence factors , was induced by catalase in this cell line , whereas c fos , c jun , and KC mRNA levels were not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our findings demonstrate high levels of c fos , c jun , and jun B mRNA transcripts during the proliferative period of osteoblast development , while expression of fra 1 and fra 2 is enhanced during the differentiation period . jun D is constitutively expressed during the time course exhibiting only a 30 % decline in levels postproliferatively , and fos B mRNA is undetectable by Northern blot analyses . ^^^ At this time , fra 1 expression is completely downregulated , while c fos , fra 2 , c jun , jun B , and jun D show a dramatic enhancement in expression . ^^^ Developmental studies of oncogene expression and transgenic animal studies implicate c fos and other fos and jun family members in the regulation of bone tissue formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of TRE regulated genes by NO releasing agents and cGMP analogs appeared to be mediated by the AP 1 ( Jun / Fos ) transcription factor complex because we observed increased DNA binding of AP 1 and increased junB and c fos mRNA in cells treated with these agents . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study we have investigated the induction of immediate early gene ( IEG ) c fos , c jun , junB and junD mRNAs and proteins in interstitial cells of rat testis after hCG treatment in vivo using in situ hybridization and immunocytochemistry . ^^^ A prominent induction of c fos , c jun and junB mRNAs and proteins in Leydig cells was seen after hCG treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , AML1 / Evi 1 stimulated c fos promoter transactivation and increased AP 1 activity , as Evi 1 ( which is not normally expressed in hemopoietic cells ) did . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun proto oncogene expression by asbestos is ameliorated by N acetyl L cysteine in mesothelial cells . ^^^ Asbestos fibers cause dose dependent , persistent increases in mRNA levels of c jun and c fos proto oncogenes in rat pleural mesothelial ( RPM ) cells , the progenitor cells of asbestos induced mesothelioma ( N . ^^^ Here we report that addition of N acetyl L cysteine decreases asbestos mediated induction of c fos and c jun mRNA levels in a dose dependent fashion . ^^^ Pretreatment of cells with buthionine sulfoximine , an agent which diminishes glutathione pools , increases the magnitude of induction of c fos and c jun mRNA by asbestos . ^^^ These oxidant stresses did not decrease cellular glutathione levels nor alter mRNA levels of c fos or c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cytokine tumor necrosis factor alpha ( TNF alpha ) and the growth factor basic fibroblast growth factor ( bFGF ) are known to induce early response genes such as c fos and c jun in various cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To identify recently activated cells in the synovial membrane ( SM ) of patients with rheumatoid arthritis ( RA ) , the in situ expression of the proto oncogenes jun B , c jun , jun D , and c fos was assessed by means of immunohistochemistry and in situ hybridization techniques . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Localization of myogenin , c fos , c jun , and muscle specific gene mRNAs in regenerating rat skeletal muscle . ^^^ We have characterized the spatial and temporal expression patterns of myogenin , c fos , c jun , and muscle creatine kinase mRNAs during the skeletal muscle regeneration process using in situ hybridization histochemistry . ^^^ Transcripts for c fos and c jun mRNAs are expressed first in the myonuclei / nuclei of satellite cells at 3 h post trauma . c jun mRNA is expressed in both myoblasts and myotubes , while c fos mRNA was not detected in these cells . ^^^ These results suggest that myogenin plays important role in the regeneration of injured muscle and that c jun and c fos may have different roles in this process . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thyrotropin releasing hormone and c fos / c jun genes are colocalized in rat anterior pituitary cells : stimulation of transcription by glucocorticoids . ^^^ The protooncogenes c fos / c jun belong to the class of immediate early genes that are activated in neurons by a variety of stimuli , including GC . ^^^ To determine whether c fos / c jun are involved in regulating the effect of GC on TRH in rat anterior pituitary cells , the coexpression and nuclear transcription activity of TRH and c fos / c jun after dexamethasone ( DEX ) stimulation ( 7 days ) were investigated . ^^^ The double labeled in situ hybridization results demonstrated that TRH and c fos / c jun are coexpressed in anterior pituitary cells and that DEX ( 10 ( 8 ) M ) enhanced the cell intensity for TRH and c fos / c jun . ^^^ The mean cell intensity of treatment vs . control was 2 . 4 fold for TRH , 1 . 4 fold for c fos , and 1 . 4 fold for c jun ( n = 24 ; P < 0 . 01 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of a single injection of caffeine on the expression of c fos , c jun , junB , and junD , on activator protein 1 ( AP 1 ) and on the levels of preproenkephalin mRNA in rat striatum was studied . ^^^ Furthermore , by using gel shift assay we found an induction of AP 1 by caffeine ( 100 mg / kg ) in striatum , which peaked 2 hr after administration and was clearly increased after 4 hr . c Fos , c Jun , and JunB proteins were components of the AP 1 . ^^^ The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c fos , c jun , and junB induction , followed by changes in AP 1 and preproenkephalin mRNA . ^^^ By using in situ hybridization of adjacent sections we found a rapid , transient , and dose dependent increase of c fos , c jun , and junB by caffeine in striatum , especially in the lateral part . ^^^ A strong induction of junB , a weak induction of c fos and c jun , but not of junD , was seen in nucleus accumbens . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The early response genes , c fos , c jun , and c myc encode proteins that regulate gene transcription , thus influencing the cellular responses to a stimulus . ^^^ Accordingly , we studied c fos , c jun , and c myc expression in glomeruli during the rapid phase of glomerular hypertrophy that follows the onset of hyperglycemia in diabetic rats . ^^^ Northern blot analysis was performed with cDNA probes for c fos , c jun , and c myc , and GAPDH . mRNA levels for c fos increased fourfold 24 hours after the onset of hyperglycemia , but returned to baseline by 48 hours . mRNA levels for c jun increased threefold 24 hours after the onset of hyperglycemia , in diabetic glomeruli , and the increase was sustained for one week . ^^^ Intensive insulin treatment normalized blood glucose levels and abrogated the increases in c fos and c jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Up to 6 h of recirculation the spatial induction pattern of 3CH134 was similar to the pattern observed for the immediate early genes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of seven immediate early gene encoded transcription factors ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif / 268 ) was assessed simultaneously . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A pharmacological approach using agonists and antagonists at the adenosine A 1 receptor as well as openers and blockers of ATP sensitive K+ channels has been combined with an analysis of neuronal death and gene expression of subunits of glutamate and gamma aminobutyric acid receptors , HSP 70 , c fos , c jun , and growth factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Angiotensin 2 stimulation activates many immediate early response genes like c Fos , c Jun , c Myc and Egr 1 in both vascular smooth muscle cells and cardiomyocytes , independently of whether a hyperplastic or hypertrophic response is taking place . ^^^ Most of the TRE bound complexes in both unstimulated and angiotensin 2 treated cells consist of c jun / c fos heterodimers . ^^^ Treatment of C2C12 cells with H2O2 induces a dose dependent increase in c jun / c fos heterodimer binding , specifically reverted by the cysteine derivative and glutathione precursor N acetyl L cysteine ( NAC ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of human A 431 cells to microgravity strongly suppresses EGF and PMA induced c fos and c jun expression . ^^^ The decrease in c fos and c jun expression in microgravity may result in the decreased formation of the FOS and JUN proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Specifically , after sexual behavior the MPA and the bed nucleus of the stria terminalis co expressed c Fos , Jun B , c Jun . c Fos was co induced with Jun B in the VMN , and with c Jun in the AMe . ^^^ As previously reported for c Fos , there was little effect of estradiol and progesterone treatment on the brain expression of these Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , 1 mg / kg per day perindopril induced significant reductions of 50 % in c jun and 45 % in c fos expression compared with control . ^^^ CONCLUSION : The effect of ACE inhibition on intimal hyperplasia is associated with a reduction in early cellular events such as c fos and c jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Passive stretch of cardiomyocytes cultured on silicone membranes activates protein kinase cascades of phosphorylation and induces an increase in protein synthesis and the expression of both immediate early genes such as c fos , c myc , c jun , Egr 1 , and late response genes such as beta myosin heavy chain and skeletal alpha actin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This is the domain homologous to that in the serum response factor which is required for serum induction of the c fos serum response element , suggesting that serum regulation of c fos and c jun may share a common mechanism . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos sense expression by dexamethasone ( DEX ) in the absence of MMS treatment results in enhanced c fos mRNA , Fos protein , AP 1 DNA binding activity and H5hr1 induced transformation and CET . ^^^ Conversely , induction of c fos antisense expression prevents the increase in c fos mRNA , Fos protein and AP 1 DNA binding activity and eliminates CET . ^^^ MMS pretreatment , alone or in combination with infection with H5hr1 temporally and differentially increases c fos , c jun , jun B , jun D and c myc steady state mRNA levels . ^^^ Maximum induction occurs with c fos and c jun 8 to 12 h posttreatment and the magnitude of response is generally greatest in CREF cells pretreated with MMS and then infected with H5hr1 . ^^^ Enhancement in RNA levels is observed in the presence of cycloheximide indicating that ongoing protein synthesis is not required for induction of c fos , c jun , jun B or c myc expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BHQ induced expression of c jun , junB , fra 1 , and fra 2 , which encode AP 1 components , but was a poor inducer of c fos and had no effect on fosB . ^^^ Like c Fos and FosB , the Fra proteins heterodimerize with Jun proteins to form stable AP 1 complexes . ^^^ Furthermore , Fra 1 repressed AP 1 activity induced by either TPA or expression of c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Changes in the functional level of proteins as a consequence of ionizing radiation include transcription factors , for example c jun and c fos ; cell cycle arrest proteins such as GADD ( growth arrest and DNA damage inducible proteins ) and p 53 ; growth factors such as FGF , PDGF ; and other proteins leading to radioresistance . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In both cell lines , TGF beta 1 stimulates expression of c jun , whereas a rapid , transient and marked increase in c fos mRNA is only observed in the MCF 7 cells sensitive to the growth inhibitory effect of TGF beta 1 . ^^^ Depletion of protein kinase C abolishes the c fos but not the c jun response to TGF beta 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogene c fos encodes a nuclear protein that forms together with c Jun or other members of the Jun family the transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition we assayed the level of mRNA encoding c Fos , a common component of AP 1 and observed that it was indeed up regulated in infected cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These findings suggest that the rapid induction of c fos and c jun is an early event in response to mechanical stretch and might trigger [ via activator protein 1 ( AP 1 ) transcriptional factors ] events leading to muscle fibre hypertrophy . ^^^ The temporal and cellular expression of c fos and c jun in mechanically stimulated rabbit latissimus dorsi muscle . ^^^ The levels of c fos and c jun mRNA were measured by reverse transcription PCR in the rabbit latissimus dorsi muscle following three separate training regimes , i . e . passive stretch , 10 Hz electrical stimulation or a combination of the two . ^^^ Both c fos and c jun mRNA expression peaked at around 1 h after imposing stretch and at around 4 . 5 6 h after the initiation of electrical stimulation . ^^^ The combined stretch / electrical stimulation regime induced biphasic expression of both c fos and c jun mRNA , with peaks coinciding temporally with those for the individual regimes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to explore the importance of c Fos and JunB , the predominantly expressed AP 1 proteins for the phase shifting effects of light , we blocked the expression of c Fos and JunB in the suprachiasmatic nucleus of male rats , housed under constant darkness , by intracerebroventricular application of 2 microliters of 1 mM antisense phosphorothioate oligodeoxynucleotides ( ASO ) specifically directed against c fos and junB mRNA . ^^^ Light induced phase shifts of circadian rhythmic locomotor activity are associated with the expression of c Jun , JunB , c Fos and FosB transcription factors in the rat suprachiasmatic nucleus , as shown in the present study . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Modified expression of c Fos and c Jun proteins and production of interleukin 1 beta in patients with rheumatoid arthritis . ^^^ To examine the relationship between the expression of c Fos and c Jun proteins and the METHODS . ^^^ The expression of c Fos and c Jun proteins and the production of IL 1 beta in the PBMC of 11 patients with active RA was determine by Western blots and ELISA techniques , respectively . ^^^ Under LPS treatment , the PBMC of both RA patients and healthy subjects produced similar high levels of IL 1 beta without any significant changes in the expression of c Fos and c Jun proteins . ^^^ By contrast , PMA induced production of IL 1 beta was impaired in RA patients and was preceded by the disregulated expression of c Fos and c Jun proteins when compared with healthy donors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Bombesin stimulates c fos and c jun mRNAs in small cell lung cancer cells . ^^^ The effects of bombesin / gastrin releasing peptide ( BN / GRP ) on c fos and c jun gene expression were investigated using small cell lung cancer ( SCLC ) cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study illustrates how a 2 week , twice daily 7 . 5 mg / kg d amphetamine or saline regimen alters rat brain regional expression of transcription factor genes , including c fos , fos B , jun B , c jun , and zif 268 , and seeks potential correlations between those changes and alterations in neurotransmitter levels and behavioral novelty responses . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Presence of c Fos protein in the AP 1 complex was demonstrated as a supershift band in the gel mobility assay using c Fos polyclonal antibody . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Arterial mRNAs for c fos , c jun , jun B , jun D , and Egr 1 increased significantly at 1 hour after balloon injury and decreased rapidly . ^^^ Treatment with TCV 116 significantly inhibited the induction of mRNAs for c fos , c jun , Egr 1 , ODC , and fibronectin in injured artery , whereas the increase in TGF beta 1 gene expression after injury was not prevented by TCV 116 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PModS caused a labeled activating protein 1 ( AP 1 ) oligonucleotide to form a DNA protein complex , indicating activation of the c fos gene and binding of the c fos / jun complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c fos expression and reduced AP 1 binding activity . ^^^ Despite normal levels of c fos expression , we observed a reduced level of AP 1 binding activity in old cells relative to young cells treated with UV irradiation or MMS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive expression of c Fos , FosB , Fra 1 , or c Jun in rat fibroblasts leads to up regulation of the immediate early gene fra 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These elements include a proximal cyclic AMP response element ( CRE ) / AP 1 like motif ( TGACATCA ) that binds c Jun , JunD , CRE binding ( CREB ) , and ATF proteins , a near consensus glucocorticoid response element , and a distal consensus AP 1 site that binds c Fos , Fra 1 , and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In mammosomatotropes GH3B6 cells , one of the primary responses to thyrotropin releasing hormone ( TRH ) is the parallel induction of two proto oncogenes , c fos and jun B , which code for constituents of AP 1 transcription factor . ^^^ Considering that AP 1 is assumed to be involved in signal transmission from the cell surface to the nucleus , it might be thus proposed that a common stimulation of c fos and jun B gene expression is possibly involved in the activation of the PRL gene . ^^^ Multiple intracellular signallings are involved in thyrotropin releasing hormone ( TRH ) induced c fos and jun B mRNA levels in clonal prolactin cells . ^^^ To better understand the mode of action of TRH and to look for possible functions of c fos and jun B in these cells , we have investigated the role of different intracellular signals in the induction of each proto oncogene on the one hand , and on prolactin ( PRL ) release and PRL gene expression on the other hand . ^^^ Northern and dot blot analyses revealed that the activation of protein kinase C ( PKC ) , Ca ( 2+ ) or adenylyl cyclase dependent pathways acutely increased both c fos and jun B transcripts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Concurrent in situ hybridization and nuclear staining revealed that while c jun was induced in most neurons , c fos induction was restricted to neurons undergoing chromatin condensation , a hallmark of apoptosis . ^^^ Antibodies specific for either c Jun or the Fos family ( c Fos , Fos B , Fra 1 , and Fra 2 ) protected NGF deprived neurons from apoptosis , whereas antibodies specific for Jun B , Jun D , or three nonimmune antibody preparations had no protective effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that beta 2 ARs stimulate c fos mRNA accumulation , increase AP 1 binding activity , and stimulate transcription through the phorbol ester responsive element ( TGACTCA ) . ^^^ Deletion studies revealed that beta 2 ARs stimulate c fos transcription through at least three distinct regulatory sequences : ( a ) the CRE located at 60 bp 5 ' to the initiation site , ( b ) the fos AP 1 like element ( 291 to 297 ) , and ( c ) the serum responsive element ( 297 to 317 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using model spontaneously reverting cell lines , c jun , junB , junD and c fos oncogene expression was investigated . c jun , but not junB , junD or c fos , was overexpressed in highly tumorigenic clones . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously demonstrated that stress causes a rapid and transient elevation in the expression of the immediate early genes ( IEGs ) c fos and the members of the jun gene family in the brain . ^^^ The time course of the induction of NGFI A , NGFI B , fra 2 and TIS 11 was similar to that previously observed with c fos and the members of the jun family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive expression of c fos induces joint destruction without lymphocyte infiltration in antigen induced arthritis in mice , and supports cell growth of human rheumatoid synovial cells , possibly acting on the AP 1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of ionizing radiation on c fos , c jun and jun B mRNA levels were determined in cultures of rat perinatal type 1 astrocytes and two rat brain tumour cell lines , 175A and 9L . ^^^ In astrocyte cultures 10 ray doses as low as 1 Gy induced the expression of c fos and jun B but had essentially no effect on c jun . ^^^ In contrast , doses of up to 20 Gy had no effect on c fos , c jun and jun B mRNA levels in the two brain tumour cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Crystal structure of the heterodimeric bZIP transcription factor c Fos c Jun bound to DNA . ^^^ We have determined the 10 ray crystal structure of a heterodimer of the bZIP regions of c Fos and c Jun bound to DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c Fos and c Jun proteins bind an AP 1 site and activate transcription synergistically . ^^^ Phosphorylation of the c Fos and c Jun HOB 1 motif stimulates its activation capacity . ^^^ Since c Fos HOB 1 has a conserved Thr residue ( T 232 ) analogous to c Jun S 73 we have proposed that c Fos HOB 1 will be regulated in the same way as c Jun HOB 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein components of this complex are specifically competed by an AP 1 consensus motif and were shown by supershift to include c Jun and c Fos , suggesting that this binding site is an AP 1 motif and that the Jun and Fos families of transcription factors play a role in the regulation of the kappa light chain gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The preincubation of nuclear extracts from control and TGF beta treated LTIC with antibodies against c jun and c fos rendered a reduced binding of AP 1 proteins to the target S 360 fragment . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study was undertaken to assess the effects of a single or two sequential topical applications of 12 O tetradecanoylphorbol 13 acetate ( TPA ) on the expression of c fos , c jun , junB , c myc , and ornithine decarboxylase ( ODC ) in promotion sensitive SSIN mice and the relatively promotion resistant C57BL / 6 strain . ^^^ In contrast , two treatments of SSIN mice with TPA caused a rapid , strong c fos induction 1 2 h after treatment , whereas C57BL / 6 mice responded no more strongly than after a single treatment . c jun mRNA and protein were induced only slightly in either strain , but junB was induced about fivefold in SSIN mice and tenfold in C57BL / 6 mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The treatment induced a transient increase in c fos , c jun , and jun B mRNA levels , with maximum values at 12 h , a transient increase in collagenase mRNA level , with maximum value at 48 h , and a progressive increase in vimentin and lamin A and C mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After 1 hour of exposure to TGF beta 1 , the jun B transcript response ranges from eightfold to 24 fold , the c fos transcript response ranges between sixfold and sevenfold . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This prolongation of the prereplicative phase has been localized to a point early in G 1 , after the induction of `` immediate early ' ' G 1 genes such as c fos and c jun but before maximal expression of `` early ' ' G 1 genes such as ornithine decarboxylase ( ODC ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Comparison of the AP 1 binding and transactivation activities in c fos / and + / + fibroblasts by electrophoretic mobility antibody supershift and CAT assays suggests that c Fos is not a major component of AP 1 complexes in these cells . ^^^ It is therefore conceivable that the lack of any detectable effect on cell proliferation in c fos / cells might be due to a functional redundancy among the different AP 1 family members . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The leucine zippers of c fos and c jun for progesterone receptor dimerization : A dominance in the A / B heterodimer . ^^^ Chimeric constructs were made linking the zip of either c fos or c jun to the C terminus of hPRB or hPRA ( hPR zip ) to produce A fos , B fos , A jun or B jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mutagenesis of IM 1 enhances the ability of c Fos to activate an AP 1 bearing promoter . ^^^ The c Fos protein has three activation modules at its C terminus , two of which contain motifs ( HOB 1 and HOB 2 ) which are also present in the activation domains of c Jun . ^^^ GAL 4 fusion experiments showed that ID 1 can specifically silence HOB 1 containing activation domains from c Fos or c Jun when linked in cis , but will not affect other distinct activation domains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemistry of the immediate early gene products c Fos and c Jun revealed abnormal activation within cortical and limbic structures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using computerized image analysis , the changes in messenger RNA expression for c fos , c jun , jun B , jun D , nerve growth factor 1 A and nerve growth factor 1 B and for neurotensin , glutamate decarboxylase , proenkephalin , the dopamine D 1 receptor and the short and long isoforms of the D 2 receptor were examined in the caudate putamen . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Distribution of immediate early gene zif 268 , c fos , c jun and jun D mRNAs in the adult cat with special references to brain region related to vision . ^^^ The distribution of immediate early gene zif 268 , c fos , c jun and jun D mRNAs was investigated in the visual cortex , dorsal lateral geniculate nucleus and hippocampus of the adult cat brain with in situ hybridization . ^^^ In area 17 , zif 268 , c jun and jun D were found predominantly in layers 2 3 and 6 , while c fos mRNA was abundant in layer 6 . ^^^ In area 18 , the zif 268 , c fos and c jun labelling pattern was identical to that of area 17 , this was not true for jun D . ^^^ In area 19 , only c jun retained the lamination pattern of areas 17 and 18 , while zif 268 , c fos and jun D were homogeneously distributed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest that H2O2 activates protein kinase and phosphatase dependent signal transduction pathways to induce c jun and c fos expression which may regulate lens crystallin genes and other genes containing AP 1 binding sites . . ^^^ The redox active components H2O2 and N acetyl L cysteine regulate expression of c jun and c fos in lens systems . ^^^ It is now demonstrated , for the first time in a lens system , that H2O2 at concentrations found in cataract patients induces expression of both c jun and c fos . ^^^ At optimal concentrations of H2O2 , mRNA accumulation of c jun and c fos in the rat lenses is induced 20 and 18 fold above normal levels respectively , but with distinct kinetics . ^^^ The antioxidant N acetyl cysteine ( NAC ) has a dual effect on the induction of c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Rapid increases in c fos , fos B , jun B , and c jun mRNA levels accompany withdrawal , with the relative level of induction correlating with the severity of physical dependence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , the steady state mRNA levels for c fos , c jun , nerve growth factor induced gene A , and the orphan steroid receptor nur 77 were rapidly induced within the first two hours of the treatment . ^^^ Furthermore , transient co transfection experiments demonstrated that c fos and c jun could repress androgen receptor mediated gene induction . ^^^ The above studies suggest that ( 1 ) the repression of androgen induction of gene expression by TPA activated PKC is at least in part due to overexpression of c jun and c fos and ( 2 ) PKC may be a negative growth regulator in prostate cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The alpha 1 adrenoreceptor linked c Fos protein , which is coordinately induced with JunB , does not form a stable component of nocturnal activator protein 1 activity . ^^^ In contrast , parallel experiments showed that c Fos does form a major component of the hippocampal activator protein 1 complex that is induced in rats following kainic acid treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemical analysis of the protein expression c myc , ets 1 , ets 2 , TPR met , c fos , c jun , c ras pan , p 53 , yes , src in 79 samples of normal , metaplastic squamous epithelium , intraepithelial and invasive squamous cell carcinoma of uterine cervix was performed using polyclonal rabbit antibodies to the synthetic peptides homologous active areas of corresponding oncoproteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cinnamyl 3 , 4 dihydroxy alpha cyanocinnamate ( 10 microM ) also inhibited the expression of c fos and c myc mRNA and , to a lesser extent , c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The two putative isoforms of the cholecystokinin B / gastrin receptor expressed in mouse fibroblasts showed the same characteristics in their ligand bindings , the major signal transduction such as phosphoinositides production , cytoplasmic Ca2+ increase , tyrosine phosphorylation of focal adhesion kinase , activation of mitogen activated protein kinase , and the induction of early responsive genes such as c fos , c myc , and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of HT 1080 cells to OA resulted in marked and persistent induction of junB , junD , and c fos mRNA levels up to 24 h , while c jun mRNA levels were only slightly elevated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In our studies we analysed c fos , fos B , c jun , jun B and jun D mRNA levels as well as a functional feature of AP 1 , its DNA binding activity , in the rat brain following systemic injection of kainate . ^^^ Two and six hours after the treatment , AP 1 consisted predominantly of Fos B , c Fos , Fra 2 and Jun B , while at 72 h Jun D constituted the major AP 1 component in place of Jun B , and no c Fos was detected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition to c fos , c myc and ornithine decarboxylase gene , 7 primarily inducible genes , c jun , KC , JE , 2F1 , 2A9 , egr 1 , and egr 2 , were further shown to be expressed after serum stimulation at both permissive and nonpermissive temperatures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the absence of treatment the levels of mRNA for the genes c jun , c fos , c myc , Ha ras and p 53 were increased in the EMT 6 / CTX and EMT 6 / CDDP as compared with the EMT 6 / parent tumor , whereas the expression of erb 2 was similar in all three tumors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c jun and c fos mRNA and protein was also examined in the same cell extracts . ^^^ Dose response analyses also revealed a coordinate down regulation of GR and c jun ( but not POMC or c fos ) mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To study the pathways of angiotensin signal transduction , protein kinase C ( PKC ) epsilon as well as cardiac c fos and c jun mRNA levels were analyzed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In growth arrested CEF , small amounts of Fra 2 / c Jun complex bind to the AP 1 consensus sequences in fra 2 promoter , while a significant part of the enhanced AP 1 binding activity after 60 120 min of serum stimulation is attributable to c Fos / c Jun heterodimer . ^^^ Transient expression assays in F 9 cells indicated that c Fos / c Jun heterodimers have strong stimulatory effects on fra 2 promoter activity , while Fra 2 / c Jun complex has lower transcriptional activity than that of c Jun homodimer . ^^^ These results suggest that c Fos ( induced at earlier times ) and c Jun proteins are at least partly responsible for serum induced expression of fra 2 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we have investigated whether the early activation of AP 1 is essential for any or all of the 5 Src responses by using a mutant c Fos that comprises the leucine zipper and a disrupted basic region . ^^^ Expression of the c Fos mutant partially reduced cellular AP 1 activity in exponentially growing cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Co transfection with expression plasmids for c jun and / or c fos showed that Jun itself induced the luciferase activity , whereas Fos inhibited both the basal and TPA induced luciferase activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Deliberation of lysosomal enzymes , enhanced cGMP and tumour necrosis factor alpha ( TNF alpha ) productions by LPS as well as interaction of Ad early gene expression with prednisolone utilized cellular transcription factors including AP 1 ( c jun , c fos ) are implicated in these processes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While there is good evidence in favour of a direct role for MAP kinase in the growth promoting effects of insulin and the regulation of Glut 1 and c fos expression , and AP 1 transcriptional complex activity , this is by no means conclusive . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The exposure to MC and / or PMA caused a rapid increase in c fos mRNA content , which was immediately followed by an increase in c jun mRNA , prior to NGF mRNA elevation . ^^^ The contransfection of mouse astroglial cells with expression plasmids of c fos and / or c jun and NGF promoter gene showed that simultaneous expression of both c fos and c jun genes was necessary to enhance NGF promoter activity . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We now report significantly greater inductions of c fos , c jun , jun B , and Egr 1 , but not jun D , mRNA in the central nervous system ( CNS ) of LS versus SS mice after the intraperitoneal administration of oxotremorine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Changes in the steady state mRNA levels for two nuclear proto oncogenes ( c fos and c jun ) and one cytokine ( TGF beta 1 ) were quantified in response to short ( 30 min ) and long ( 24 48 h ) treatments of these cells with physiologic concentrations of steroids . ^^^ The results indicated that neither 10 nM dihydrotestosterone , 10 20 nM testosterone , nor 10 100 nM androstenedione had a significant effect on the steady state levels of c fos , c jun , or TGF beta 1 mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear run on assays indicated that okadaic acid also activated NGF gene transcription , which was preceded by an induction of c fos and c jun gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present results demonstrate that neurotransmitters released from splanchnic nerve terminals induce expression of c fos , c jun , and junB in adrenal chromaffin cells which results in increased AP 1 DNA binding activity . ^^^ Neuronal regulation of c fos , c jun , and junB immediate early genes in rat adrenal medulla . ^^^ We have applied in situ hybridization histochemistry , Northern analysis , and immunocytochemistry to study the regulation of the immediate early gene ( IEG ) c fos , c jun , and junB mRNAs and the respective proteins in the rat adrenal medulla . ^^^ Stimulation with nicotine also caused a drastic increase in the mRNA levels , whereas muscarine only induced moderate elevations . c fos and c jun were induced strongly in adrenaline cells and only weakly in noradrenaline cells . junB was upregulated mainly in adrenaline cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , nicotine induced a marked elevation of the immediate early gene mRNAs c fos , c jun , and jun B . ^^^ Maximally increased levels for c fos mRNA ( about 100 fold ) were obtained after 20 min . c jun and jun B were increased three to fivefold 60 min after nicotine addition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Glucocorticoid regulation of c fos , c jun and transcription factor AP 1 in the AtT 20 corticotrope cell . ^^^ Since it has been shown that CRF stimulates c fos in AtT 20 corticotrope cells , and that c fos over expression elevates POMC transcription , the current study has investigated whether GC can repress c fos and c jun gene expression and AP 1 DNA binding activity in AtT 20 corticotrope cells . ^^^ These data suggest that in the corticotrope cell relatively high levels of activated GR may influence CRF induced AP 1 DNA binding via transient genomic actions on basal c jun and stimulated c fos and / or via direct protein : protein interactions . . ^^^ Acute treatment with doses of dexamethasone ( DEX ) that markedly inhibited nuclear POMC hnRNA had no effect on basal c fos mRNA expression , but resulted in a transient down regulation of c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased expression of c fos mRNA and AP 1 transcription factors after cortical impact injury in rats . ^^^ Levels of c fos mRNA and AP 1 transcription factors co expression were measured in a controlled lateral cortical impact model of traumatic brain injury ( TBI ) in rats . ^^^ These data indicate that TBI can produce significant increases in c fos expression and subsequent upregulation of the AP 1 transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also observed cocaine induced activation of AP 1 DNA binding activity in striatal extracts prepared at these different ages , suggesting that the observed induction of c fos and c jun may have biological consequences for the developing brain . ^^^ The products of such genes ( e . g . , c Fos , c Jun , and Zif / 268 ) subserve the coupling of cell surface receptor stimulation to transcriptional regulation . ^^^ We report that , during rat brain development , cocaine produced brain region specific and developmental age specific induction of c fos , c jun , and zif / 268 mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Lithium in combination with other inducers caused delayed increases in both AP 1 binding activity and c jun , c fos and fra 1 gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ribonucleic acid samples from the cells were monitored for the expression of a group of immediate early genes ( IEGs ) , including c fos , c jun , TIS 1 , TIS 7 , TIS 8 , TIS 11 and TIS 21 , by northern blot hybridization analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A single nicotine injection resulted in a rapid and transient activation phase of nerve growth factor 1 A , c fos and jun B at 20 min , and a later and less prominent activation of c jun , which stayed high from 20 to 60 min . there was a parallel slow and long lasting activation of jun D , which remained high 4 h after nicotine treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Rat hearts infused with the beta adrenergic agonist isoproterenol were examined for the expression of several nuclear proto oncogenes ( c fos , fosB , c jun , junB , and junD ) and the immediate early gene Egr 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study UV induced expression of the immediate early response genes c fos and c jun and the secondary response gene type 4 collagenase in TD , growth arrested and stem 3T3 T cells was investigated by northern blot analysis . ^^^ At each UV dose ( 0 10 J / m2 ) there was an increase in c fos and , to a lesser extent , c jun expression 0 . 5 h after irradiation in each 3T3 T phenotype as compared with unirradiated controls . ^^^ The increases in c fos and c jun expression were transient in each phenotype reaching maximums from 0 . 5 to 1 h after irradiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The aim of this study was to analyze the effect of angiopeptin pretreatment on the level of expression of the c fos and c jun protooncogenes , early markers of smooth muscle cell proliferation , after balloon denudation of rabbit aorta . ^^^ Expression of c fos and c jun was detected 30 minutes after injury ; angiopeptin pretreatment at 20 micrograms . kg 1 . d 1 induced a 41 % reduction in c fos expression and a 42 % reduction in c jun expression compared with control animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mobility gel shift assays revealed increased binding of c Fos and c Jun to the AP 1 transcription factor site after a single immobilization , and the binding was not further elevated with repeated stress . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two hours after this stimulation , an increased number of immunoreactive cells for c fos related antigens , c jun , and NGFI A was demonstrated . ^^^ These studies indicate that developing ( P 7 ) optic nerves show a baseline expression of c fos related antigens , c jun and NGFI A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of c fos , c jun , c erbB 1 , c erbB 2 and c myc in primary lung carcinomas and their lymph node metastases . ^^^ The purpose of this study was to identify possible alterations in proto oncogenes ( c fos , c jun , c erbB 1 , c erbB 2 and c myc ) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Paralleling the increase in DYN expression , APO also induced the expression of c Fos and Fos related antigens ( FRA ' s ) , in particular a 35 kDa FRA , but had no effect on the expression of various Jun related IEG proteins ( i . e . , c Jun , Jun B , Jun D ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Colocalization of c fos mRNA in haloperidol responsive NT neurons in the DLSt suggests that haloperidol ' s induction of NT / N gene transcription may involve participation of the transcription factor Fos and the AP 1 consensus sequence in regulatory region of the NT / N gene . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The messenger RNAs encoding the immediate early genes of the leucine zipper family ( c fos , c jun , jun B ) , the Zinc finger family ( zif 268 ) , the glucocorticoid receptor family ( NGFI B ) and the interferon family ( PC 4 ) are increased within 2 h after the lesion and return to normal levels at 6 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Molecular basis for somatostatin action : inhibition of c fos expression and AP 1 binding . ^^^ The products of some of these genes , such as c fos and c jun , are known to form a heterodimeric transcription factor complex ( AP 1 ) that binds specifically to the consensus sequence TGAC ( G ) TCA . ^^^ Accordingly , we examined the effects of somatostatin on c fos gene expression and on the binding of the AP 1 complex to its specific DNA element using isolated gastric parietal cells and the GH 3 pituitary cell line . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
HC 11 cells carrying a glucocorticoid inducible Ha ras ( val 12 ) construct were transfected with a chloramphenicol acetyltransferase ( CAT ) reporter gene under the control of a human fos promoter which includes the serum response element ( SRE ) , the adjacent c fos AP 1 site ( FAP ) and the cAMP response element ( CRE ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Corticotropin ( ACTH ) and insulin like growth factor 1 increased c fos and jun B mRNA , but had no effect on c jun mRNA and these early changes were associated with a later increase in BAC specific function [ ACTH receptors , cytochrome P 450 17 alpha ) and 3 beta hydroxysteroid dehydrogenase ( 3 beta HSD ) ] and an enhanced steroidogenic responsiveness to both ACTH and angiotensin 2 ( A 2 ) . ^^^ On the other hand , A 2 increased the three proto oncogene ( c fos , c jun and jun B ) mRNAs , induced a decrease of P 450 17 alpha and 3 beta HSD and caused a marked homologous and heterologous ( ACTH ) densitization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Promoter regions of the preproenkephalin , preprodynorphin , and c fos genes contain cyclase response elements ( CREs ) as well as AP 1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Twenty minutes after a single THC injection , significant increases in concentration of the mRNAs for C FOS , C JUN and ZIF 268 were observed in the cingulate cortex ( 75 , 45 and 37 % ) and for C FOS and ZIF 268 in the fronto parietal cortex ( 60 and 64 % ) and caudate putamen ( 81 and 32 % ) while JUN D mRNA levels were not changed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PWM induced an early and transient increase in the expression of immediate early response genes of the jun / fos leucine zipper family ( c jun , jun B , c fos , and fos B ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential expression of c jun , c fos and hsp 70 mRNAs after folic acid and ischemia reperfusion injury : effect of antioxidant treatment . ^^^ The purpose of this study was to examine the time course of the expression of two early growth response genes , c jun and c fos , and of the stress response gene hsp 70 after such renal injuries and to determine the role played by reactive oxygen species generated during reperfusion , on gene induction . ^^^ Ischemic injury caused an almost immediate increase of c jun , c fos and hsp 70 mRNA expression , that reached a maximum at 1 h of reperfusion . ^^^ Folic acid treatment increased c fos and hsp 70 mRNAs at 2 h , while c jun accumulated at 1 h , although to a lesser extent . ^^^ In contrast , the combined administration of allopurinol and DMSO reduced c jun and c fos mRNA expression as well as tubular cell damage at 1 h of reperfusion , although not at earlier times while hsp 70 mRNA expression remained almost unchanged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This treatment is associated with increased expression of c myc , c fos , jun family members , and transforming growth factor beta 1 mRNA and with partial proteolytic cleavage of poly ( ADP ribose ) polymerase and lamin B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This enhanced stability was not an universal response to genotoxic stress since other DNA damage inducible genes , such as c jun and c fos , did not show an appreciable increase in mRNA half life . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Irradiation of HeLa cells with short wavelength ultraviolet light ( UVC ) induces the modification and activation of the preexisting transcription factors c Fos c Jun ( AP 1 ) and TCF / Elk 1 , as well as the protein synthesis independent transcriptional activation of the c fos and c jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recent work has shown that DNA damaging agents activate signaling cascades one of which involves the Src , Ras , and Raf proteins as intermediates and results in induction of a number of genes , including c fos , c jun , and the growth arrest and DNA damage inducible ( gadd ) genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos , c jun and jun B mRNAs was studied in six different brain areas by means of Northern blot hybridization , c fos expression was also studied with in situ hybridization and immunohistochemistry . ^^^ The periodicity of c fos and jun B oscillation persisted also when the animals were exposed for 6 days to constant ( 24h / 24h ) light or darkness . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The distal region is required for activation of Ras , Raf 1 , MAP kinase and p 70 S6 kinase as well as induction of c fos and c jun , but is dispensable for GM CSF dependent proliferation of transfectants under normal culture conditions containing serum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Evi 1 raises AP 1 activity and stimulates c fos promoter transactivation with dependence on the second zinc finger domain . ^^^ Evi 1 caused stimulation of the c fos promoter transactivation , which seems to be a main mechanism of AP 1 activation , through at least two portions of the promoter . ^^^ It was shown that the second zinc finger domain is essential for the activation of AP 1 and transactivation of the c fos promoter . . ^^^ Evi 1 transfected P 19 cells showed some differentiated phenotypes and increased expression of endogenous c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 activity in nuclear extract from the H 2 c fos T cells was also higher than that from the control cells . ^^^ These results suggest that c Fos / activator protein 1 is a major regulatory factor for IL 2 gene expression in splenic T cells activated through the TCR / CD3 complex . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , transfected c jun , jun B , jun D , c fos , or Fos B expression vectors partially substitute for TPA and Ca2+ and cooperate with Oct 2 for the transactivation of the combined OAP / octamer cis element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The aim of this study was to show whether reduction or loss of cortical cholinergic activity results in any particular change in the expression of the proto oncogenes c fos and / or c jun . ^^^ Brain sections of adult rats that had received an intracerebroventricular injection of 4 micrograms of the 192IgG saporin were subjected to in situ hybridization using oligonucleotides to detect c fos and c jun mRNA . ^^^ In situ hybridization revealed a considerable increase in the level of c fos mRNA in the lateral septum following the cholinergic lesion , whereas in the medial septum both c fos and c jun mRNA were elevated . ^^^ Immunolesioning led to a distinct and specific increase in the level of c jun but not c fos mRNA in the parietal and occipital cortex that was restricted to cortical layer 4 . ^^^ These data suggest that reduced cortical cholinergic activity differentially regulates expression of c fos / c jun genes in distinct cortical regions of the rat brain . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thus , high glucose may effect gene expression of ECM proteins by elevating the transcription factors c fos and c jun which complex with one another to form activator protein 1 ( AP 1 ) . . ^^^ High glucose elevates c fos and c jun transcripts and proteins in mesangial cell cultures . ^^^ Using quantitative reverse transcription ( RT ) PCR , we now report that mRNA levels for c fos and c jun were increased approximately twofold after treatment with high glucose . ^^^ Immunofluorescence studies with polyclonal antibodies to c fos and c jun revealed that high glucose treatment for four hours increased nuclear staining intensity two to threefold for both proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also observed that GF 109203X at 1 microM inhibited serum stimulation of expression of mRNA for c fos and c jun , which are usually involved in cellular proliferation . ^^^ We also observed that GF 109203X inhibited c fos and c jun mRNA expression in these cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Anisomycin activated protein kinases p 45 and p 55 but not mitogen activated protein kinases ERK 1 and 2 are implicated in the induction of c fos and c jun . ^^^ Thus , the EGF and anisomycin activated kinases p 45 and p 55 are strongly implicated in signalling to c fos and c jun , whereas the MAP kinases ERK 1 and 2 are not essential for this process . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential regulation of c fos , fosB , c jun , junB , bcl 2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion . ^^^ To obtain information in vivo about a possible relationship between u . v . induced proto oncogene expression and cellular alterations , we have analysed the expression of c fos , fosB , c jun , junB , bcl 2 and bax in rat epidermis after single and chronic u . v . irradiation . ^^^ Single u . v . irradiation causes a rapid and sustained increase in c jun , junB and c fos mRNA and a decline in bcl 2 transcripts , whereas expression of bax remained unchanged . c Fos and c Jun immunoreactivity was localized throughout the epidermal cell layers 1 . 5 h after single irradiation , but restricted to basal cells at 48 h suggesting an involvement in both u . v . induced apoptosis and hyperproliferation . 48 h after chronic exposure a significantly higher induction and a totally different pattern of epidermal proto oncogene expression was detectable which may be associated with malignancy . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription factor AP 1 is comprised of multiple protein complexes that include members of a family of genes related to the proto oncogene c fos . ^^^ Transcription factor AP 1 is comprised of multiple protein complexes that include members of a family of genes related to the proto oncogene c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using both models , IEG mRNAs ( c fos and c jun ) were analyzed by Northern blot hybridization at various times before and after reperfusion . ^^^ In shunted LI and fresh liver OLT groups ( viable ) , c fos and c jun mRNAs increased markedly to a peak value within 1 2 hr of reperfusion , returning to basal level by 3 hr . ^^^ Our data suggest that a protracted pattern of expression of c fos and c jun in the liver at the early stage of reperfusion might be correlated with the severity of liver transplant related insults and subsequent graft failure . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of some members of the Immediate Early Gene ( IEG ) family such as c jun and c fos is one of the first molecular events following peripheral nerve damage . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is concluded that ( 1 ) transforming Ha ras induces c fos in HC 11 cells via PKC ( presumably epsilon ) , ( 2 ) the signal is mediated to the serum response element ( SRE ) of the fos promoter and ( 3 ) the fos AP 1 ( FAP ) site is not required for this mechanism . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Suppression of ischemia induced fos expression and AP 1 activity by an antisense oligodeoxynucleotide to c fos mRNA . ^^^ These results support the hypothesis that increased AP 1 binding activity following focal cerebral ischemia is dependent on Fos expression and can be inhibited in vivo by antisense c fos oligodeoxynucleotides . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Eventually the activation of MAP kinase leads to the activation of the elongation factor 4E and several transcription factors such as c Jun , c Myc and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Acetaldehyde induces c fos and c jun proto oncogenes in fat storing cell cultures through protein kinase C activation . ^^^ We here evaluated whether acetaldehyde increases Col 1 and FN gene transcription through the induction of c fos and c jun proto oncogenes and studied the possible role played by protein kinase C ( PKC ) and c AMP . ^^^ We conclude that acetaldehyde increases procollagen 1 and fibronectin gene transcription in FSCs , possibly through c fos and c jun expression , and that PKC may play a regulatory role in this chain of events . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun proto oncogenes in target cells of the lung and pleura by carcinogenic fibers . ^^^ To study mechanisms of cell proliferation by asbestos and nonasbestos fibers , we examined the effects of these agents on the mRNA levels of c fos and c jun and ornithine decarboxylase ( ODC ) in hamster tracheal epithelial ( HTE ) cells and rat pleural mesothelial ( RPM ) cells , the progenitor cells of bronchogenic carcinoma and mesothelioma , respectively . ^^^ No c fos mRNA was detected in HTE cells after exposure to particulates , but exposure of HTE cells to H2O2 caused striking increases in c fos and c jun , which preceded increases in ODC mRNA . ^^^ In RPM cells , crocidolite and chrysotile asbestos caused increases in mRNA levels of both c fos and c jun . ^^^ Moreover , erionite , a fiber extremely potent in the causation of mesothelioma in humans , caused more dramatic elevations in c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of cell growth by butyrate was associated with a complex pattern of cell cycle regulated gene expression , including a decoupling of c fos and c jun gene expression . ^^^ Transcription of c fos , as well as c jun increased with butyrate arrest , whereas steady rate mRNA levels of c jun only were increased , suggesting additional regulation of c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 1 beta causes an increase in c fos , AP 1 transcriptional activity and an increased expression of several genes including NGF , but the initial signalling events are unknown . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Curcumin inhibits TPA induced expression of c fos , c jun and c myc proto oncogenes messenger RNAs in mouse skin . ^^^ In the present studies , we investigated the effect of curcumin on the expression of c fos , c jun and c myc oncogenes in TPA treated mouse skin in CD 1 mice . ^^^ A 30 nmol dose of TPA increased the levels of mRNAs for c fos , c jun and c myc oncogenes by 2 3 fold compared with control . ^^^ Inhibition of expression of c fos and c jun was more pronounced than that of c myc . ^^^ A dose of 10 mumol of curcumin was found to inhibit 90 % TPA induced expression of c fos and c jun , and 60 % of c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of curcumin on 12 O tetradecanoylphorbol 13 acetate and ultraviolet B light induced expression of c Jun and c Fos in JB 6 cells and in mouse epidermis . ^^^ Topical application of 10 mumol curcumin together with 5 nmol TPA once a day for 5 days strongly inhibited TPA induced epidermal hyperplasia and c Jun and c Fos expression . ^^^ A single application of 180 mJ / cm2 of ultraviolet B light ( UVB ) to the backs of SKH 1 mice caused epidermal hyperplasia and expression of c Fos and c Jun in the muscle layer of the dermis and of c Fos in the suprabasal layer of the epidermis . ^^^ Application of 10 mumol curcumin to mouse skin twice a day for 5 days immediately after UVB exposure had only a small / variable inhibitory effect on UVB induced increases in the expression of c Fos and c Jun and on epidermal hyperplasia . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Super shift assays identified Jun D and c Fos proteins in the band shift complexes observed with control and beta naphthoflavone treated Hepa 1 nuclear extracts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun mRNA at the M / G1 border is required for cell cycle progression . ^^^ The proto oncogenes c fos and c jun have been shown in numerous model systems to be induced within minutes of growth factor stimulation , during the G0 / G1 transition . ^^^ While c fos mRNA levels drop to undetectable levels within 2 hr after division , c jun mRNA levels are maintained at a basal level which is approximately 30 % maximum throughout the remainder of G 1 . ^^^ In order to access the functional significance of these patterns of c fos and c jun expression , antisense oligodeoxynucleotides specific to c fos or c jun were added to either actively growing Swiss 3T3 cells or mitotically synchronized cells , and their ability to inhibit DNA synthesis and cell division determined . ^^^ Our results show that treatment of Swiss 3T3 cells with either c fos or c jun antisense oligodeoxynucleotides , while actively growing , during mitosis , or in early G 1 , results in a reduction in ability to enter S and subsequently divide . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Under the same conditions , the expression of genes such as c myc , c jun and c fos , which are known to have important roles in growth and differentiation , has been measured . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This age related attenuation of the hypertrophic response may be attributed to the diminished induction of proto oncogenes such as c fos , c myc and c jun by hemodynamic stress . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this report using immunocytochemical and in situ hybridization techniques we demonstrate for the first time that in addition to c fos , pilocarpine administration increases the neuronal expression of jun B , krox 20 and krox 24 ( zif 268 ) but not related c jun and jun D genes in rat cortex and hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A single administration of ethanol simultaneously increases c fos mRNA and reduces c jun mRNA in the hypothalamus and hippocampus . ^^^ To determine whether ethanol may have differential effects on c fos and c jun expression , we injected male rats acclimated to a 25 degrees C environment with ethanol ( 3 g / kg b . wt . ) or saline . ^^^ Using in situ hybridization histochemistry with oligonucleotide probes , we found that ethanol increased c fos mRNA in the PVN , but decreased c jun mRNA both in the PVN and in hippocampus . ^^^ Considering that ethanol produces hypothermia and that the PVN contains neurons activated during hypothermia , we evaluated the effect of cold on c fos and c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immobilization stress induced c fos and jun B mRNAs in the parvocellular region of the hypothalamic paraventricular nucleus , the anterior and intermediate lobes of pituitary , and in the adrenal gland after 7 min of immobilization , although no c fos or jun B mRNAs were detected in these and other organs in control rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine if axotomy induced immediate early gene ( IEG ) expression accompanies regenerative efforts in central nervous system ( CNS ) neurons , immunohistochemistry using antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins was used to examine gene expression in identified adult rat retinal ganglion cells ( RGCs ) under two conditions : ( 1 ) after axotomy alone , and ( 2 ) 1 month after replacement of the optic nerve with an autologous peripheral nerve graft to allow axonal regrowth . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In striatum , cocaine increases the relative levels of c Fos , Fos B , Jun B , and Jun D proteins that bind the AP 1 DNA sequence element , whereas in the cerebellum only c Fos and Jun D binding activities are increased . ^^^ In the striatum , acute cocaine administration increases cellular levels of c fos and jun B mRNA , whereas transcriptional effects in the cerebellum are limited to c fos mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In NIH3T3 cells expressing active Raf 1 protein serine / threonine kinase ( PSK ) c jun expression is constitutive while c fos expression is attenuated . ^^^ The results clearly demonstrate that Raf 1 dependent oncogenes , which include receptor protein tyrosine kinases ( PTKs ) , intracellular PTKs and Ras derived genes share the Raf phenotype of constitutive c jun expression , attenuated c fos induction , and high sensitivity to growth suppression by TAM 67 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of the ribozyme resulted in decreased expression of c fos , as well as that of the MDR gene ( mdr 1 ) , c jun , and mutant p 53 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RA repressed serum stimulated induction of the immediate early genes c fos and c jun , whose protein products dimerize to form AP 1 . ^^^ That repression of c fos by RA might contribute to anti AP 1 activity was suggested by experiments with an antisense c fos expression vector , which demonstrated that c fos induction was required for serum stimulated AP 1 activity . ^^^ Selective repression of c fos and c jun might contribute to the anti AP 1 activity of RA . . ^^^ Repression was relatively selective for c fos / c jun ; induction of other immediate early transcription factors ( junB , c myc , and egr 1 ) was not downregulated by RA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This age related attenuation of the hypertrophic response may be attributed to the diminished induction of proto oncogenes such as c fos , c myc and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although the CG beta CREs do not contain consensus sequences previously described to bind c Jun , CRE 2 bound c Jun and c Fos in electrophoretic mobility shift assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A unilateral hypoxia ischaemia ( HI ) 21 day old rat preparation was used to assess the effects of HI on the expression of the immediate early gene proteins ( IEGPs ) c Fos / FRAs , Fos B , c Jun , Jun B , Jun D , Krox 20 , Krox 24 , and on the mRNA for the neurotrophic factor , brain derived neurotrophic factor ( BDNF ) . ^^^ Moderate HI ( 15 min hypoxia ) produced delayed , selective neuronal death and was associated with a rapid induction of c Fos , Fos B , Jun B , Jun D , and c Jun proteins , but not Krox 20 protein or BDNF mRNA , in neurons on the side of HI and also a delayed expression of c Jun ( and to a lesser extent c Fos / FRA ' s and Fos B ) 24 48 h after HI in neurons that underwent delayed neuronal death . ^^^ Severe HI ( 60 min hypoxia ) resulted in seizures and rapid neuronal loss and infarction ( necrotic cell death ) on the side of HI , and was associated with early induction of c Fos , Fos B , c Jun , Jun B , Jun D , Krox 20 and Krox 24 protein and BDNF mRNA in neurons on the non ligated side of the brain . ^^^ Thus , moderate HI induces IEGP ' s in neurons and non nerve cells in damaged regions , whereas severe HI induces IEGP ' s and BDNF in non damaged regions . c Jun ( and to a lesser extent c Fos / FRA ' s ) showed a prolonged expression in neurons undergoing delayed , but not necrotic , cell death suggesting that they may be involved in the biochemical cascade that causes selective delayed neuronal death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blots demonstrated induction of the genes in the order of c fos = jun B > c jun > jun D with large increases in the cerebral cortex , hippocampus , and striatum , a smaller increase in the cerebellum , and less in the brainstem . ^^^ Treatment with pilocarpine ( 30 mg / kg ) alone increased mRNA levels in the order of c fos > jun B > c jun but did not change the jun D mRNA level , and maximal c fos and jun B mRNA levels occurred earlier ( 30 min ) in the cortex than in the hippocampus . ^^^ The mRNA levels were increased during seizures in the order of c fos > jun B > c jun > jun D in the hippocampus and jun B > c fos > c jun > jun D in the cortex , and were increased for a longer duration as well as to a greater extent than after administration of pilocarpine alone . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of c fos , c jun , or both expression vectors with the intact or 5 ' deleted ERCAT constructs identified several Fos responsive inhibitory regions within the EGF receptor promoter , but these did not localize to the 919 to 860 promoter region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To date , most of the work in this general area has focused primarily on the regulation of three genes : c fos , c jun , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , both Northern blot and immunohistochemical analysis showed that these tumors exhibited changes in the mRNA and protein expression levels respectively of the immediate early transcription factor genes c fos , c jun , and EGR , in that less expression of these genes was evident in the tumors compared with adjacent normal tissue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 site binding complex ( es ) induced by all three treatments reacted with antibodies directed broadly against fos and jun protooncogene families and against the specific family members c fos , junB , and junD but not c jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To further characterize the molecular mechanism by which IGF 1 increases AP 1 activity , we analysed the transcription regulation of c fos and c jun using reporter genes containing the respective promoters or specific regulatory elements . ^^^ Similar studies revealed that c fos stimulation by IGF 1 requires the presence of a regulatory sequence spanning the dyad symmetry element ( DSE ) and the fos AP 1 like sequence ( FAP ) . ^^^ Insulin like growth factor 1 stimulates c fos and c jun transcription in PC 12 cells . ^^^ The control of IGF 1 on c fos and c jun transcription was studied in PC 12 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 1 beta ( IL 1 beta ) decreased the levels of type 2 collagen mRNA and increased the levels of mRNAs for collagenase , stromelysin , and immediate early genes ( egr 1 , c fos , c jun , and jun B ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential regulation of proto oncogenes c jun and c fos in T lymphocytes activated through CD 28 . ^^^ In this paper , we report that cross linking of CD 28 ( but not CD 2 , CD 5 , LFA 1 , or CD 7 ) leads to an elevation of c jun mRNA , with only minimal activation of c fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive upregulation of calcium channel currents in rat phaeochromocytoma cells : role of c fos and c jun . 1 . ^^^ Northern blot analysis and cell transfection were used in conjunction with whole cell current recordings to examine the involvement of the immediate early genes , c fos and c jun , in the expression of calcium channel currents . 2 . ^^^ The levels of c fos and c jun mRNAs increased transiently during each daily exposure to NGF . ^^^ The level of c fos mRNA also increased transiently during repeated KCl induced depolarizations but c jun mRNA remained low or absent . 5 . ^^^ Naive PC 12 cells were transiently co transfected with expression plasmids that contained the full length of c fos and c jun cDNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined the molecular phenotype of neonatal rat cardiac fibroblasts in relation to ANG 2 by studying the expression pattern of three transcription factors ( Egr 1 , c fos and c jun ) and the transforming growth factor beta 1 ( TGF beta 1 ) . ^^^ The expression of Egr 1 and c fos was induced as early as 15 min that reached maximal levels at 45 min and declined thereafter , whereas c jun was induced at 45 min and remained elevated up to 2 hrs of ANG 2 addition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined the influence of these ligands on the activity of reporter constructs containing the AP 1 site , the serum response element ( SRE ) and the cyclic AMP responsive element ( CRE ) of the c fos promoter under control of an heterologous promoter . ^^^ Therefore , repression of c fos gene expression by T 3 and RA receptors appears to be exerted through transcriptional interference with the SRE and the AP 1 binding site of the promoter . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the early response genes c fos , c jun , Egr 1 , and c myc was also studied , since their protein products may be involved in controlling natriuretic peptide gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Insulin treatment of Chinese hamster ovary ( CHO ) cells expressing high levels of the insulin receptor ( CHO / IR cells ) activates both c fos serum response element and activator protein 1 ( AP 1 ) reporter genes approximately 10 fold . ^^^ Consistent with the Shc Grb 2 pathway as the major route for insulin stimulated c Fos and AP 1 transcriptional activation , the IRS 1 mediated inhibition was reversed by transfection with an expression plasmid for Grb 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our studies indicate that a ) increased expression of proto oncogenes such as c fos , c jun , and c myc is not necessary for entry into the cell cycle during mitogen induced liver growth ; b ) mitogen induced liver growth does not support initiation of chemical hepatocarcinogenesis ; c ) repeated proliferative stimuli induced by primary mitogens do not stimulate the growth of initiated cells to a focal and / or nodular stage ; and d ) mitogen induced liver growth , unlike compensatory regeneration , is followed by a particular mode of cell death , namely , apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also found that apoptotic mouse 3T3 fibroblasts express c fos , c myc , c jun , and cdc 2 , as well as the upregulation of RB phosphorylation and BrdU incorporation , just before final DNA fragmentation and death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protooncogene c fos encodes a nuclear protein that acts as a powerful enhancer of gene transcription , and shares the same general patterns of reactivity to stimulation as ornithine decarboxylase , an essential enzyme in cell replication and differentiation ; c fos enhances expression of proteins whose genes possess the AP 1 consensus sequence , which include ornithine decarboxylase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our results showed that EGF treatment caused rapid increases in c fos , c jun , and junB expression ( P < 0 . 001 ) in both cell lines . c fos and c jun followed similar time courses , peaking at 30 min , whereas junB levels plateaued at 1 hr . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NMDA receptor mediated excitoprotection of cultured cerebellar granule neurons fails to alter glutamate induced expression of c fos and c jun mRNAs . ^^^ Since the neurotrophic and excitoprotective effects of NMDA in cerebellar granule neurons may involve changes in the expression of the immediate early genes c fos and c jun , we measured c fos and c jun mRNAs in cerebellar granule neurons after exposure to either toxic concentrations of glutamate or excitoprotective ( subtoxic ) concentrations of NMDA . ^^^ Exposure of cerebellar granule neurons to toxic concentrations of glutamate induced a dramatic increase in c fos and c jun mRNAs which was not associated with a corresponding increase in c fos and c jun proteins as measured immunocytochemically . ^^^ However , the increase in c fos and c jun mRNAs induced by toxic concentrations of glutamate was not altered by preexposing cerebellar granule neurons to NMDA , suggesting that increased expression of c fos and c jun mRNAs is not sufficient for glutamate toxicity of these neurons . ^^^ Preexposure of cerebellar granule neurons to NMDA for 24 h , which induced a maximal excitoprotective state , resulted in a transient increase in c fos , and to a lesser degree c jun , mRNAs similar to that induced by toxic concentrations of glutamate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Seizure elicited immediate early gene ( IEG ) expression was investigated after various postictal survival times ( up to 24 h ) , using immunocytochemistry with specific antisera against seven IEG encoded proteins ( c FOS , FOS B , c JUN , JUN B , JUN D , KROX 24 , KROX 20 ) . ^^^ Postictal expression kinetics of individual IEG encoded proteins within the transplants were strikingly similar to those seen in the neocortex in situ . c FOS and KROX 24 were most rapidly induced , followed by c JUN and JUN B , and a more delayed induction of FOS B , JUN D and KROX 20 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study , therefore , attempts to define and correlate the physiological processes in the rat uterus following estrogen and tamoxifen administration with temporal events manifested by mRNA expression of protooncogenes ( m myc , c ras , c fos , c jun ) , growth factors and / or inhibins ( IGF 1 , IGF 2 , IGF 2 Exon 1 and Exon 2 ) , EGF , TGFB 1 , 2 , 3 ) , growth factor or inhibin receptors ( EGFr , TGFB 2r , TGFB 3r ) , and estrogen induced differentiative proteins including estrogen receptor ( ER ) , progesterone receptor ( PR ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The reconstitution studies of IL 2Rs with alpha , beta and gamma chain genes demonstrated that each subunit has potential for altering the affinity of the receptor , and the cytoplasmic domains of the beta and gamma chains participate in signal transduction in terms of cell growth , activation of alpha tyrosine kinase and enhancement of c myc , c fos and c jun transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In rat cortex , a meningo cortical injury causes complex changes in the expression of the `` immediate early ' ' genes c fos and c jun as well as the neuropeptide gene procholecystokinin . ^^^ Within 1 h , mRNA levels of c fos and c jun are enhanced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , both TPA and IL 1 alpha caused increases not only in the phosphorylation of c Jun and c Fos protein but also in the transactivating activity of AP 1 nuclear transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , acute administration of the atypical antipsychotic drug clozapine ( CLOZ , 30 mg / kg ) induced only FRAs , JunB and Krox 24 IEGPs in the striatum , and c Fos , FRAs , and Krox 24 IEGPs in the nucleus accumbens . c Jun was not induced by acute administration of HAL or CLOZ in the rat brain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Complexes of c fos / c jun constitute the AP 1 transcription factor and the HPV 16 promoter / enhancer contains AP 1 enhancer elements . ^^^ Since EGF is capable of stimulating cellular signal transduction , we have compared levels of EGF induced c fos and c jun mRNA in E 5 expressing 3T3 cells . ^^^ We present data showing that the expression of c fos and c jun was higher in E 5 expressing 3T3 cells than in control cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of other serum inducible genes , including c jun and beta actin , was not suppressed in ras transformed Rat 1 cells , indicating that these effects are specific for c fos and that growth factor signal transduction pathways remain essentially intact . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this model , TRH also raises c fos proto oncogene mRNA levels . c fos is assumed to be involved in the transduction of external signals to the nucleus as a component of AP 1 transcription factor , a complex that contains a member of the jun proto oncogene family . ^^^ Hence , the main aim of this study was to look for the expression of c jun , jun B , and jun D proto oncogenes in TRH stimulated GH3B6 cells , compared to c fos mRNA levels and PRL secretion . ^^^ This stimulation was dose dependent and exhibited an early peak and a long lasting plateau phase stabilized at 4 h , similar to TRH induced c fos mRNA induction . c jun mRNA was expressed at minute levels in control cells and was transiently stimulated by TRH . ^^^ Thyrotropin releasing hormone stimulates in parallel jun B and c fos messenger ribonucleic acids in GH3B6 pituitary cells : comparison with PRL secretion . ^^^ TRH induced jun B and c fos responses were characteristic of immediate early genes as shown by the superinduction observed under cycloheximide treatment and the total inhibition elicited by actinomycin D . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The EMSA supershift method provided an evidence that Jun B and c Fos and probably Fos B are major components of AP 1 at 2 h after the seizures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An analysis of the effects of IL 1 and TPA on immediate early gene expression indicated that IL 1 preferentially induced c jun gene expression , whereas TPA greatly increased c fos and zif / 268 gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 4 inhibits several monocyte functions like A 23187 induced expression of cytokines and c fos and c jun proto oncogene mRNA expression . ^^^ In an attempt to elucidate the mechanism by which this inhibitive effect is mediated , we compared the effect of IL 4 on A 23187 induced c fos and c jun mRNA expression in conjunction with inhibitors that selectively inhibit the cyclooxygenase dependent ( indomethacin ) and lipoxygenase dependent ( NDGA ) pathway of arachidonic acid ( AA ) metabolism . ^^^ This was supported by the finding that leukotriene B 4 ( LTB 4 ) and 5 ' hydroperoxyeicosatetraenoic acid ( 5 ' HPTETE ) , which are two lipoxygenase metabolites , strongly induced c fos mRNA , whereas c jun mRNA expression was slightly affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oncoproteins c myc , c fos , c jun , L myc , c sis , c ras , c src , c ets 1 , c met were studied immunohistochemically in the material obtained from 25 patients during the operations . ^^^ A higher expression of c fos , c jun , c ets 1 and c met is observed at early stages of progression and that of c myc and L myc at later stages . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c fos proto oncogene is believed to play a pivotal role in transducing growth factor mediated signals from the extracellular milieu into the nucleus . c fos protein dimerizes with c jun and related proteins and mediates transcription via AP 1 sites . ^^^ The overall levels of AP 1 DNA binding activity are normal and several genes ( c jun , MCP 1 , metallothionein ) known to contain functional AP 1 sites are expressed normally in the c fos deficient and control cells . ^^^ These results clearly demonstrate that some AP 1 dependent genes require c fos for full expression while others do not ; oncogenes may activate expression of metalloproteases via either fos dependent or fos independent mechanisms . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RNA blot hybridization analysis was used to determine steady state messenger RNA levels for c jun , jun B , jun D , c fos , fos B , fra 1 , nup 475 , and zif 268 . ^^^ Intraperitoneal injection of lipopolysaccharide is followed by induction ( from fivefold to 13 fold ) of c jun , jun B , c fos , zif 268 , and nup 475 messenger RNAs in the liver . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , in both types of cells , c fos , c jun , and c myc mRNAs were induced after 1 , 1 , and 4 hours of EGF treatment , respectively , whereas they required 8 hours of contact with EGF to induce proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of a ts 5 Src kinase rapidly increases activity of both the transcription factor , AP 1 , and MAP kinase , an enzyme that enhances AP 1 activity by both phosphorylation of c Jun and increased c fos transcription ; the relative contribution of these two events depends on the cells in which 5 Src is expressed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein kinases C beta and C epsilon link the mast cell high affinity receptor for IgE to the expression of c fos and c jun . ^^^ In this report we identify the specific isozymes of protein kinase C ( PKC ) that are involved in c fos and c jun mRNA accumulation in the rat basophilic leukemia cell line RBL 2H3 . ^^^ The reconstitution of these cells with defined concentrations of either PKC beta or PKC epsilon up to 10 nM and 20 nM , respectively , induced c fos and c jun in a dose dependent manner . ^^^ At high concentrations of PKC beta and epsilon the induction of c fos and c jun was independent of the aggregation of the high affinity IgE receptors ( Fc epsilon type 1 receptors ) . ^^^ In contrast , at limiting concentrations of these two PKC isozymes , 1 nM , the increase in c fos and c jun mRNAs was dependent on the aggregation of the Fc epsilon type 1 receptors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein composition of the latter differed from the former mostly by substitution of Jun B with Jun D protein and lack of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Chem . 268 , 9526 9532 ) demonstrated that tumor necrosis factor alpha ( TNF alpha ) induces monocyte chemoattractant JE / MCP 1 expression via c fos and c jun genes following protein kinase C activation in osteoblastic MC3T3 E 1 cells . ^^^ RA pretreatment transcriptionally suppressed the expression of the c fos gene but not that of the c jun gene in TNF alpha treated cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos , junB , c jun , and hsp 70 mRNA in cortex , thalamus , basal ganglia , and hippocampus following middle cerebral artery occlusion . ^^^ Middle cerebral artery ( MCA ) occlusion in halothane anesthetized rats induced c fos , junB , and c jun immediate early gene mRNAs and hsp 70 heat shock gene mRNA in brain . ^^^ By 24 h , there was little expression of c fos , junB , c jun , and hsp 70 in the core of the MCA infarct ; there was modest induction of hsp 70 at the margins of the infarct ; and there was diffuse induction of c fos , junB , and c jun in all of the cortex outside the infarct . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrate that isolation of hepatocytes from the normal quiescent rat liver by collagenase perfusion activates the immediate early growth response program , as indicated by increased expression of c jun , junB , c fos , and c myc mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regional and global myocardial ischemia and reperfusion have been demonstrated to induce expression of the stress response protein heat shock 70 ( HSP 70 ) and of immediate early genes , c jun , c fos , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IGF 1 stimulates the expression of c fos , c jun , junB , and egr 1 . ^^^ TSH inhibits basal levels of c jun expression in quiescent cells and represses serum and IGF 1 stimulated c jun , c fos , and egr 1 expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ras can stimulate AP 1 activity by inducing c fos transcription , a process which is probably mediated by the ERK 1 and 2 mitogen activated protein ( MAP ) kinases , which phosphorylate the transcription factor Elk 1 / TCF . ^^^ A short sequence surrounding the major JNK phosphorylation site of c Jun is conserved in c Fos and is part of its activation domain , suggesting that c Fos may be similarly regulated . ^^^ Here we show that Ras does indeed augment the transcriptional activity of c Fos through phosphorylation at Thr 232 , the homologue of Ser 73 of c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Peripheral noxious stimulation leads to a rapid and transient expression of c fos , c jun and other immediate early genes ( IEGs ) in the spinal cord . ^^^ In the present study we have shown that superfusion of rat spinal cord with antisense oligodeoxynucleotides complementary to c fos mRNA suppresses heat induced c Fos protein expression without affecting other members of the Fos and Jun family , thus providing a technique to determine the function of IEGs in vivo . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In U 2 Os cells , the level of c jun mRNA was higher than in the other two cell lines , whereas none of these cell lines exhibited detectable levels of c fos mRNA at the confluent stage . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the development of kindling is sensitive to pharmacological blockade of the N methyl D aspartate receptor , we tested whether the increased expression of the immediate early genes c fos , jun B , c jun , krox 20 , and krox 24 following a kindling afterdischarge was also sensitive to N methyl D aspartate receptor blockade by MK 801 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
SCH 23390 attenuated morphine induction of AP 1 binding in striatum , suggesting that c fos and junB contribute to AP 1 binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The IL 10 effects are selective since it reduced PTK dependent cytokine mRNA expression but not the PTK independent induction of c jun and c fos mRNA in LPS activated monocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The serine / threonine protein phosphatase inhibitor okadaic acid ( OA ) was found to enhance mRNA transcripts of c fos and of the jun family of proto oncogenes including c jun , jun B and jun D in cultured pheochromocytoma PC 12 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The time course of expression and localization of the immediate early inducible genes : c fos , c jun , zif 268 ; nerve growth factor , brain derived neurotrophic factor and the related tyrosine kinase high affinity receptor ( trkB ) messenger RNAs were studied by in situ hybridization . ^^^ The levels of messenger RNAs for c fos , zif 268 , brain derived neurotrophic factor ( but not nerve growth factor ) and trkB were consistently increased in cortex ipsilaterally to the lesion , while c jun messenger RNA content was only slightly increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results show that increasing intracellular levels of cAMP by exposing the cells to the synthetic adenosine analogue N ethyl carboxamido adenosine ( NECA ) results in an accumulation of c jun and c fos mRNA in both cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , IL 2 induced activation of JAK 3 paralleled induction of the c myc gene and DNA synthesis but not induction of the c fos and c jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We analyzed the expression of c fos and jun family gene in murine pre B cells developed in the interleukin 7 ( IL 7 ) dependent bone marrow cell culture . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recent studies have demonstrated that the early response genes c jun , Egr 1 , c fos , and NF kappa B are induced following exposure of mammalian cells to ionizing radiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In MCT cells , an SV 40 transformed mouse proximal tubule cell line , incubation in acid media led to transient increases in c fos , c jun , junB , and egr 1 mRNA abundance , peaking at 30 min to 1 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We previously showed that the high affinity human GMR reconstituted by cotransfecting the alpha and beta chain cDNA clones transduces signals in response to hGM CSF to activate transcription of c fos , c jun , and c myc proto oncogenes in mouse proB cell line BA / F3 or in mouse fibroblast NIH3T3 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we report a new function of t , its ability to repress human c fos promoter and AP 1 transcriptional activity in CV 1P cells . ^^^ In keeping with the possibility that t affects the expression of the genomic c fos promoter , it also led to repression of AP 1 formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription rates of cell growth and bone related genes ( including histone H 4 , c fos , c jun , TGF beta 1 , beta 2 macroglobulin , collagen , fibronectin , osteocalcin , osteopontin , and tartrate resistant acid phosphatase ) change as a function of calvarial development from birth to 6 weeks and are selectively modified in osteopetrotic animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNA expression was determined for the proto oncogenes c jun and c fos , whose protein products join to form transcription factor AP 1 , which is necessary for activation of the IL 2 promoter . ^^^ Burn splenocytes showed normal expression of mRNA for c jun but diminished expression of mRNA for c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have characterized the genomic response of astroglial cells to excitatory amino acids by using selective agonists and antagonists for the various receptor subtypes and by analyzing different primary response genes , such as members of the Fos ( c fos and fosB ) and Jun ( c jun , junB , and junD ) families , zif / 268 , and c myc . ^^^ A rapid and transient elevation of mRNA levels for c fos , fosB , c jun , junB , and zif / 268 was observed after addition of glutamate to cultured astrocytes , whereas junD and c myc expression was not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Denervation and axotomy induced c fos , NGFI A , c jun , jun B and jun D mRNA expression for up to 6 days in non neuronal cells , whereas in sympathetic neurons the expression of only c jun mRNA was induced after axotomy and sialectomy . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have examined the expression of immediate early genes in central neurons of the rat and now show that a 6 hydroxydopamine induced axotomy of the dopaminergic nigrostriatal pathway results in a substantial increase in the levels of c jun ( but not c fos ) messenger RNA and protein within neurons of the substantia nigra pars compacta . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expressions of c JUN , JUN B , c FOS FOS B and KROX 24 proteins were investigated by immunocytochemistry following the application of formalin ( 5 % , 50 microliters ) into the plantar skin of one hindpaw . ^^^ The expression of c JUN , JUN B , FOS B and KROX 24 proteins paralleled that of c FOS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
P glycoprotein 170 may be regulated by the c fos / c jun protein complex , which binds specifically to AP 1 . . ^^^ P glycoprotein associated expression of c fos and c jun products in human lung carcinomas . ^^^ Surgical specimens of non small cell lung carcinomas of 167 previously untreated patients were analyzed for expression of c fos , c jun , c myc and c neu products and for resistance to drugs . ^^^ An association between the resistance and c fos and c jun proteins was found ( c fos p = 0 . 01 , c jun p = 0 . 09 ) , whereas a correlation between resistance and expression of c neu and c myc products was not observed . ^^^ Also a significant correlation between the c fos and c jun proteins and the expression of P glycoprotein was found ( c fos p = 0 . 017 , c jun p = 0 . 036 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Prognostic significance of the expression of c fos , c jun and c erbB 1 oncogene products in human squamous cell lung carcinomas . ^^^ The expression of the oncogenes c fos , c jun , c myc , c erbB 1 and c erbB 2 at the protein level was analyzed in squamous cell lung carcinomas of 121 patients by means of immunohistochemistry . ^^^ Patients with overexpression of proteins encoded by the oncogenes c fos , c jun and c erbB 1 had significantly shorter survival times than these without overexpression of these oncogene products ( c fos : p = 0 . 009 ; c jun : p = 0 . 029 ; c erbB 1 : p = 0 . 018 ) . ^^^ In addition to the univariate analyses ( Kaplan Meier estimates ) multivariate analyses ( Cox regression model ) revealed that protein expression of the oncogenes c fos , c jun and c erbB 1 are significant prognostic factors in addition to staging . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have found that brief ( 30 s to 2 min ) stimulation of neurons with vasoactive intestinal peptide ( VIP ) and SKF 38393 , a D 1 dopaminergic receptor agonist , potently increased mRNA levels for the IEGs c fos , jun B , and NGFI A , with weaker increases for c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously characterized a dominant negative mutant of c Jun called TAM 67 which forms dimers with c Jun and c Fos , and binds DNA as a homodimer or heterodimer with c Jun or c Fos . ^^^ In addition , to determine whether TAM 67 functions through the formation of homodimers , or through interactions with endogenous c Jun or c Fos , we constructed a pair of chimeric proteins made by replacing the leucine zipper of TAM 67 with the leucine zippers of GCN 4 and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential expression of the immediate early genes c fos , c jun , junB , and NGFI B in the rat brain following transient forebrain ischemia . ^^^ The temporospatial expression pattern of four immediate early genes ( IEGs ) ( c fos , c jun , junB , NGFI B ) following 30 min of global ischemia was investigated in rat brains by in situ hybridization and immunohistochemistry ( c fos ) . ^^^ After recirculation , c jun mRNA appeared to be initially coinduced with c fos mRNA , but c jun mRNA levels remained elevated or increased in various regions , including all vulnerable regions , when c fos mRNA had already declined to near basal levels . ^^^ Compared to c fos and c jun , junB induction was less pronounced and confined largely to the dentate gyrus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Site directed mutagenesis of the AP 1 binding sites in the albumin enhancer partially abrogated the suppressing effect of ras and c jun / c fos on the enhancer . ^^^ Subsequent functional assays showed that overexpression of c jun and c fos inhibited the activity of the albumin enhancer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using antisera specific to individual Fos and Jun family members , we show that c Fos as well as other Fos family members are present in the inducible AP 1 and NFAT complexes of activated murine T cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
FOS and JUN proteins are induced by ACTH independently of cell cycle stage . c Fos , fos B , fra 1 , fra 2 , c jun , and jun B genes are induced by ACTH , the kinetic profiles for mRNAs and respective protein products being similar , except for a 1 h protein delay . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we report that hippocampal focal brain injury transiently induces the immediate early genes c fos , jun B , c jun and krox 24 ( zif 268 ) messenger RNA and protein and brain derived neurotrophic factor messenger RNA in rat dentate gyrus neurons , an effect that was blocked by the N methyl D aspartate receptor antagonist MK 801 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study the expression of vascular smooth muscle alpha actin , tropoelastin , c fos and c jun were examined via immunoblotting , immunohistochemistry , Northern blot , and / or transcription run on assays . ^^^ The results show that , when they are grown under identical conditions in vitro or freshly removed from an embryonic vessel , surrogate MDM VSMC express about 10 times more alpha actin and tropoelastin than the normal NC VSMC ; and MDM VSMC express up to 15 times more c jun , whereas c fos was not different . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrate that PDT mediated oxidative stress induced a transient increase in the early response genes c fos , c jun , c myc , and egr 1 in murine radiation induced fibrosarcoma cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immediate early gene expression was examined by Northern blotting : both thrombin and PDGF induced egr 1 , c fos , c jun , junB , and fra 1 mRNAs within 15 min ; the response was maximal at 30 60 min ( increases ranging from 2 . 9 to 9 . 3 fold over control serum deprived cells ) and returned to base line levels within 2 4 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By using anti c Fos antibodies we show that AP 1 is binding to the MyoD 1 CRE like element . ^^^ Our results indicate that AP 1 negatively modulates MyoD 1 expression in growing myoblasts and strongly suggest that c Fos and c Jun inhibit myogenesis and MyoD 1 expression by direct binding to a negative cis acting element in the MyoD 1 promoter . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
During functional neuronal differentiation of human SH SY5Y neuroblastoma cells , induced by 12 O tetradecanoylphorbol 13 acetate ( TPA ) , the mRNA expression of c fos and c jun displayed a synchronous and biphasic type of induction for both mRNAs , with an early transient ( 30 to 120 min ) and a later ( > 8 h ) more persistent increase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , the stimulatory effect on AP 1 activity was found to involve de novo transcription of the c jun and c fos components but to be independent of protein kinase C activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Localization of c fos , c jun , and hsp 70 mRNA expression in brain after neonatal hypoxia ischemia . ^^^ In agreement with our previous northern blot analysis , in situ hybridization of coronal brain sections to probes for c fos , c jun , and heat inducible hsp 70 revealed a marked induction and subsequent disappearance of all three mRNAs during this time period . ^^^ We observed co localization of the 2 immediate early gene ( IEG ) mRNAs , c fos and c jun , which encode proteins that act in combination to regulate subsequent gene expression . ^^^ The temporal and regional co localization of c fos and c jun suggests that the transcriptional regulatory activity of their protein products could play a role in plasticity associated with death or recovery from injury in the immature brain . ^^^ Although the most frequent site of expression for all three mRNAs was the ipsilateral cerebral cortex , hsp 70 expression was restricted to the ipsilateral hemisphere and absent from a number of structures that were positive for c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast to the increased c jun mRNA levels under hypotonic conditions , expression of the c fos proto oncogene was unaffected by changes in the osmolarity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we show that the AP 1 components c Jun and c Fos are induced by IL 3 . ^^^ While c Jun ' s induction by IL 3 is totally dependent on PKC , c Fos induction by IL 3 is only attenuated by PKC depletion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reduced co expression of the c fos and c jun protooncogenes has been correlated with the down regulation of H 2K class 1 major histocompatibility antigens in high metastatic cell lines from the Lewis lung carcinoma , B 16 melanoma and the K 1735 melanoma . ^^^ Transfection of c jun and c fos genes into the high metastatic clones D 122 ( 3LL ) and F10 . 9 ( B 16 melanoma ) resulted in activation of H 2 class 1 gene expression . ^^^ D 122 transfectants expressing high levels of c jun and c fos and F10 . 9 transfectants expressing high levels of c fos exhibited markedly reduced tumorigenicity and were of low metastatic potential . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein kinase A and AP 1 ( c Fos / JunD ) are induced during apoptosis of mouse mammary epithelial cells . ^^^ Elevated nuclear protein kinase A ( PKA ) activity was observed from one day post lactation , paralleled by increased c fos , junB , junD and to a lesser extent c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously demonstrated coordinate inductions of c fos , c jun , jun B , and jun D in cardiac myocytes exposed to hypoxia for 2 to 4 hours . ^^^ The loss of intracellular ATP was followed by fourfold inductions of c fos and c jun with minor changes in jun B and jun D transcript levels . ^^^ Similarly , iodoacetic acid caused a major ( 90 % ) loss of ATP and irreversible cell damage as measured by leakage of creatine phosphokinase enzyme and loss of membrane arachidonic acid ; ATP loss was followed by fivefold to sevenfold inductions of c fos , c jun and jun B transcripts . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine whether these age related deficits involve alterations in GnRH neuronal activation , we examined expression of the immediate early gene products , c fos and Jun , in GnRH neurons of young and middle aged proestrous animals . ^^^ Regularly cycling young ( 3 to 4 month old ) and middle aged ( 10 to 12 month old ) animals were perfused transcardially at 2300 h on diestrus or at 0230 , 0530 , 0900 , 1400 , 1630 , 1930 , or 2300 h on proestrus , and the brains were processed for dual immunocytochemistry of c fos or Jun and GnRH . ^^^ In agreement with earlier studies in young rats , 34 + / 4 % of the GnRH neurons expressed c fos and 40 + / 3 % expressed Jun during the proestrous LH surge ( 1630 and 1930 h ) . ^^^ However , in the middle aged animals , there was a dramatic decline in the number of GnRH neurons that expressed c fos ( 9 + / 1 % ) and Jun ( 14 + / 1 % ) during the LH surge . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present studies determined the effects of estrogen and progesterone on expression of the growth associated , immediate early genes c fos , c jun , and jun B in the luminal epithelium of the uterus . ^^^ Estrogen stimulated c fos and jun B expression , but repressed c jun mRNA levels in the epithelium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast to interleukin 1 beta , L tryptophan induced increase in collagenase mRNA was not preceeded by expression of c jun or c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To elucidate the mechanisms involved in the inhibition of MC proliferation due to polyamine depletion , we studied the effects of DFMO on the activation of phospholipase C and induction of the immediate early genes ( IEGs ) , c fos , c jun and Egr 1 , which are thought to regulate cell growth . ^^^ This activation was not affected by DFMO . mRNAs of the IEGs c fos , c jun and Egr 1 were induced by FCS within 15 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , steady state transcript levels of the tumor associated AP 1 responsive genes stromelysin , urokinase type plasminogen activator , c jun , and c fos were higher in malignant 308 10Gy5 cells than in benign 308 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , the 2 drugs induced similar patterns of protein phosphorylation and activated the c fos and c jun genes that their protein products regulate transcription of TRE containing genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several mitogen activated protein kinases ( MAP kinases ) as well as other kinases phosphorylate c Jun and c Fos in vitro and are postulated to control AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study compared the timing of immediate early gene ( IEG ; c fos , c jun , jun B , and zif / 268 ) induction with the response of neuronal transcripts during the first 24 hr of a QA lesion within the rodent striatum . ^^^ This initial IEG phase , likely neuronal in origin , was dominated by robust increases in the expression of c fos , jun B , and zif / 268 mRNAs in contrast to small increases in c jun expression . ^^^ During this phase , c jun mRNA levels coordinately increased with c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun gene expression by phenolic antioxidants . ^^^ We have found that phenolic antioxidants specifically induce expression of the c fos and c jun protooncogenes . ^^^ After treatment of quiescent human hepatoma HepG 2 cells with butylated hydroxytoluene , butylated hydroxyanisole , or other phenolic antoxidants , the levels of c fos and c jun mRNAs are substantially increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Specific binding of RA to RAR was decreased when TPA induced expression of the c fos , c jun and ornithine decarboxylase gene was increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential induction of the two early genes c jun and c fos in weakly and strongly metastatic murine lymphoma cell lines . ^^^ Induction of the 2 early response genes c jun and c fos was investigated in the weakly metastatic T lymphoma Eb line and the related strongly metastatic lymphomacrophage ESb line to find possible correlations with their different in vitro and in vivo phenotypes . ^^^ The uncoupling of c jun and c fos induction in Eb , but not in ESb cells , as well as the uncoupling of c fos response to different stimulators , point to a differential activation of these 2 early response genes by the main signal transduction pathways in the 2 cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional studies demonstrate that the endogenous c fos protein contributes to AP 1 activity and normally suppresses regulated SRE ( serum response element ) activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have used the evoked expression of the immediate early gene encoded proteins ( c Fos , Fos B , Jun B , Jun D , c Jun and Krox 24 ) to monitor sensory processing in the hindbrain structures of rats undergoing somatic inflammation . ^^^ All immediate early gene encoded protein expressions except c Jun were evoked , but except for c Fos , and to a lesser extent Jun D , intensities of staining always remained faint . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The number of neurons expressing c Fos , c Jun , Jun B and Krox 24 were maximal after 2 h and thereafter declined . ^^^ At 2 h following noxious heat stimulation morphine had decreased the number of labelled neurons for c Fos , Fos B , Krox 24 , c Jun and Jun B to 30 60 % of control levels in laminae 1 2 and to 10 30 % in laminae 3 7 , 10 of the spinal cord . ^^^ Eight hours following noxious heat plus morphine application we did not detect noxious evoked immunoreactivity for c Fos , Krox 24 , c Jun and Jun B , while there was residual labelling for Fos B in the superficial dorsal horn and for Jun D in laminae 1 7 and 10 of the spinal cord . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the immediate early genes ( IEG ) c FOS , NGF 1 A and c JUN was induced by noxious thermal stimulation in neurons of the rat spinal cord dorsal horn . ^^^ While c FOS expression was suppressed in superficial and deep laminae of the spinal cord , NGF 1 A and c JUN was only suppressed in superficial laminae . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that inhibition of expression of the cartilage phenotype by retinoic acid in epiphyseal chondrocytes is associated with positive regulation of AP 1 responsive metalloprotease genes , as well as induction of gene expression for the two components of the transcription factor AP 1 , c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Unlike GADD 45 , the response of other DNA damage inducible genes to IR is not dependent on p 53 based on the observation that induction in a panel of cell lines did not correlate with a normal p 53 status ; this included human GADD 153 , another member of the gadd ( growth arrest and DNA damage inducible ) group ; MyD 118 , a gene related to GADD 45 ; and the protooncogenes c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , gene transcription for three immediate early genes , c fos , c jun and NGFI A , and three neuropeptide genes , enkephalin , dynorphin and neuropeptide Y , was investigated using nuclear run on assays following a single injection of the convulsant pentylenetetrazole ( PTZ ) . ^^^ Thus , regulation of immediate early and neuropeptide gene mRNA levels and immunoreactivity occurs , at least in part , at the level of transcription for the genes encoding neuropeptide Y , dynorphin , c fos , c jun , and NGFI A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thrombin or serum treatment of quiescent WS 1 cells induced protooncogenes c fos and c jun . ^^^ PMA also induced c fos and c jun with a time course similar to that of serum or thrombin . ^^^ These results suggest that the PMA induced inhibition of DNA synthesis occurs through an activation of PKC that inhibits DNA synthesis at a point after the induction of c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 complex consists of distinct protein heterodimers encoded by the proto oncogene c fos and c jun mRNA whose gene expression can be induced by TPA , cyclic AMP and growth factors . ^^^ Recent findings suggest an involvement of reactive oxygen species in the pathway of TPA and protein kinase C leading to expression of c fos and c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 1 beta and IL 6 genes contain AP 1 binding sites as regulatory elements , the AP 1 protein being composed of c jun and c fos gene products . ^^^ In THP 1 cells c jun mRNA expression increased after incubation with MDHM while positive c fos expression remained unaffected . ^^^ In the primary cells MDHM induced elevation of cytokine mRNA levels was preceded by a downregulation of c fos expression while positive c jun expression was not modulated . c myc mRNA expression , constitutively high in THP 1 cells , was induced in MDHM stimulated PBMo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Given the fact that a work by others ( Hira et al . , 1991b ) suggests that calpains can be involved in c FOS and c JUN degradation in vivo , our observations raises the possibility of a novel contribution to the regulation of AP 1 transcription complex activity through a differential control of the steady state level of some of its components that involves calpains . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fos related antigen 1 ( fra 1 ) gene is closely related to the protooncogene c fos and encodes a component of transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is well documented that norepinephrine ( NE ) induces the expression of immediate early genes ( IEGs ) , such as c fos , c jun , and jun B , in cultured neonatal heart cells and leads to cell growth without cell division ( ie , hypertrophy ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , in the case of H2O2 treated cells , the accumulation of c fos or c jun mRNAs was still pronounced 6 h after the end of the treatment and the levels of cell secreted NGF appeared relatively reduced , when compared with those obtained after a shock with the X / XOD system . ^^^ Furthermore , treatment of cells with the protein synthesis inhibitor anisomycin had an effect similar to that of H2O2 because it caused an accumulation of c fos , c jun , and NGF transcripts after 6 h of treatment . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Repression in c jun and junB inducibility in adipocytes results from transcriptional mechanisms , can be reversed by treatment with protein synthesis inhibitors or higher serum concentrations , and does not affect c fos or c myc expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Diverse agents , including growth factors and phorbol esters , induce rapid transcriptional activation of a subset of immediate early ( IE ) genes that include the protooncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found no detectable transcripts of 9 proto oncogenes ( c sis , c met , c src , c lyn , c fgr , c ros , c pim , Blym and N myc ) , but detected transcripts of 12 other proto oncogenes ( int 2 , erbB , c abl , c raf 1 , c fyn , K ras , H ras , c mos , c myc , c myb , c fos , and c jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protooncogenes c fos and c jun were coordinately upregulated in both proliferating and differentiating cells , whereas c myc transcripts were upregulated during proliferation only . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes c fos and c jun and the related jun B encode the components of transcription factor , AP 1 , a heterodimeric DNA binding protein that mediates hormone and growth factor regulated gene expression . ^^^ In the rat Sertoli cell , FSH rapidly inhibited c jun gene expression while it stimulated c fos and jun B as well as the expression of the more slowly responding , tissue plasminogen activator ( tPA ) and inhibin alpha subunit . ^^^ Nuclear run off analyses demonstrated that the FSH dependent decline in c jun and increases in c fos , jun B , tPA and inhibin alpha subunit mRNAs were regulated at the transcriptional level . ^^^ The rates of degradation of c fos , c jun and jun B mRNAs were unaffected by FSH while tPA and inhibin alpha subunit mRNAs were stabilized . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The role of a Fos Jun like complex in regulating GSTP 1 transcription in VCREMS cells was further emphasized by the introduction of point mutations within the C 1 region which were known to inhibit AP 1 binding and the interaction of antisera raised against human c Jun and c Fos with the major C 1 complex in VCREMS cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The binding of IL 2 to its specific receptor ( IL 2R ) triggers various cellular events including the induction of nuclear proto oncogenes ( c fos , c jun and c myc genes ) and the proliferation of hemopoietic cells . ^^^ We observed that the high affinity IL 2R in NIH 3T3 fibroblasts can mediate the IL 2 stimulated tyrosine phosphorylation of p42 / p44 ( mitogen activated protein kinase ) and the induction of the c fos , c jun and c myc genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There are evidences that angiotensin 2 stimulates expression of egr 1 , c jun , c fos and c myc oncogenes in vascular smooth muscle cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern analysis of U 937 cells clearly indicated that visna Tat promoted the c jun mRNA expression , in contrast to the c fos mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Upon binding of PDGF to its receptor , transactivation of transcriptional and nuclear factors such as c fos and c myc genes and dephosphorylation of c jun occurs , 5 sis , the oncogen of the simian sarcoma virus ( SSV ) , is highly homologous to the c sis / PDGF B gene that encodes the homodimer of the B chain of the PDGF receptor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Distributed changes in c Fos and c Jun immunoreactivity in the rat brain associated with arousal and habituation to novelty . ^^^ The effects of exposure to spatial novelty on expression of the immediate early gene ( IEG ) products c Fos and c Jun were mapped in the rat brain by immunohistochemistry . ^^^ Nonperfused brains were processed for immunocytochemistry for c Fos and c Jun on adjacent slices using the avidin biotin method and diaminobenzidine as chromogen . ^^^ In contrast , rats that had been exposed for the first time to the maze ( spatial novelty ) showed an extensive c Fos and c Jun like immunoreactivity in the reticular formation , the caudate putamen complex , the hippocampus ( granular and pyramidal neurons ) , the cerebellum ( granular neurons ) , and all layers of somatosensory cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although none of these receptor subunits has intrinsic kinase activity , these cytokines induce protein tyrosine phosphorylation , activation of Ras , Raf 1 and MAP kinase , and transcriptional activation of nuclear proto oncogenes such as c myc , c fos and c jun . ^^^ The beta 763 mutant , as well as the full length beta c , induced transcription of c myc , c fos and c jun . ^^^ Deletions at amino acid 517 ( beta 517 ) and 626 ( beta 626 ) induced c myc and pim 1 , but no induction of c fos and c jun was observed . ^^^ Thus , there are at least two distinct regions within the cytoplasmic domain of beta c that are responsible for different signals , i . e . a membrane proximal region of approximately 60 amino acid residues upstream of Glu 517 is essential for induction of c myc and pim 1 , and a distal region of approximately 140 amino acid residues ( between Leu 626 and Ser 763 ) is required for activation of Ras , Raf 1 , MAP kinase and p 70 S6 kinase , as well as induction of c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have investigated the expression of metallothionein genes and proto oncogenes ( c fos , c jun and c myc ) , as well as specific localization of metallothionein in the liver cells after partial hepatectomy . ^^^ Expression of the proto oncogenes c fos and c jun is elevated after partial hepatectomy , and the resultant heterodimer of gene products may contribute to the observed metallothionein gene induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The TGGGTCA specific factor is present in three cell lines tested and is composed of protein ( s ) immunologically related to c Jun and c Fos but not to the CRE binding protein , CREB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
T 3 also reduced the abundance of nuclear proteins that bind to an AP 1 binding site and the levels of c Fos protein , as determined by Western blot . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neither c fos nor c jun mRNA were detectably induced by this stimulus . ^^^ In contrast , the 50 train stimulus pattern resulted in a robust induction of c fos and c jun mRNA , in addition to zif 268 and junB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Pk C activation is necessary for IL 2 synthesis and IL 2 receptor synthesis through activation of the proto oncogenes c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulatory motifs identified in the c fos promoter , such as an Ets binding site , E boxes , a CArG box , c fos AP 1 sites , and two retinoblastoma control elements , were also found upstream of the c fos homology region . ^^^ Three independent Tax 1 responsive regions ( TRRs ) were identified , and mutations in each revealed that one of the retinoblastoma control elements in TRR 1 and the c fos AP 1 sites in TRR 2 and TRR 3 were essential for the activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of four genes necessary for DNA synthesis in response to tumor promoters was examined : two nuclear proto oncogenes ( c myc and c fos ) , a transcription factor ( c jun / AP 1 ) and a key enzyme involved in polyamine synthesis ( ornithine decarboxylase ) . c jun mRNA levels are not modulated during the action of cytoskeletal disrupting drugs on TPA mediated mitogenesis , whereas c myc and c fos mRNA levels are similarly enhanced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transfectants expressing the trkA mRNA and surface bound receptors transcriptionally activate immediate early genes ( c fos , c jun , and jun B ) following nerve growth factor ( NGF ) stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This growth arrest is accompanied by a 30 fold elevation in c jun transcript levels , no change in c fos expression , and a moderate increase in total AP 1 transcriptional activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential expression of c fos and c jun in two regions of the rat spinal cord following noxious colorectal distention . ^^^ Thoracolumbar and lumbosacral spinal segments that receive afferent input from the descending colon and rectum were stained immunocytochemically for c Fos and c Jun like proteins following repetitive , noxious colorectal distention ( CRD ) . ^^^ Noxious CRD ( 80 mmHg ) resulted in significantly more c Fos and c Jun like immunoreactivity in the sacral dorsal horn than in the thoracic dorsal horn . ^^^ In both regions of the spinal cord the increase in c Fos like immunoreactivity was at least twice that of c Jun like immunoreactivity . ^^^ Basal levels of c Jun but not c Fos were observed in the thoracic intermediolateral nucleus ( IML ) and the sacral parasympathetic nucleus ( SPN ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of these 13 genes , a delayed transient induction was observed for only 8 : c fos , c jun , jun B , jun D , c myc , ergI / krox 24 and two ' anonymous ' genes , 3L3 and 19A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
SUMMARY OF REVIEW : During the early postischemic stages , protein synthesis in the brain is generally suppressed , but specific genes are expressed and their corresponding proteins may be synthesized , such as immediate early gene products ( c fos , c jun , and zinc finger gene ) , heat shock proteins , and amyloid precursor protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CONCLUSIONS : Results are in agreement with the contention that increased c fos and jun B expression leads to increased AP 1 binding activity , which in turn has been linked to the enhanced expression of neurotrophin genes . . ^^^ RESULTS : Northern blot analysis showed that an increase in the expression of selected proto oncogenes including c fos , c jun , jun B , zif / 268 , and nur 77 were noted 30 to 90 minutes into postischemic reperfusion . ^^^ Nuclear run on experiments showed that the increase in c fos and jun B mRNA signals was due to an increase in the transcription rate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Co transfection of the expression vector for c jun also increased the CAT activity driven by the 68 kDa CPT promoter , while co transfection with the expression vector for c fos had no effect . ^^^ When expression vectors for both c jun and c fos were co transfected with the 68 kDa CPT promoter , c fos depressed the induction seen with c jun alone . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To test the hypothesis that the antiproliferative effect of heparin in vivo may be related to an inhibition of proto oncogene expression , the effects of pretreatment with heparin on the expression of the c myc , c fos and c jun proto oncogenes were examined in a rabbit model of balloon denudation . ^^^ This inhibition is not associated with an overall decrease in the level of expression of the c myc , c fos , or c jun proto oncogenes in the arterial wall , suggesting that the antiproliferative effect of heparin may be due to an effect on other events in the cell cycle . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A single d amphetamine dose ( 7 . 5 mg / kg , i . p . ) enhances behavioral stereotypy and augments brain expression of c fos , fos B , fra 1 , zif 268 , jun B , and c jun by 2 11 fold . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In situ hybridization was used to assess regional levels of four immediate early gene messenger RNA levels ( c fos , c jun , junB , and a nerve growth factor induced gene , NGFI A ) . ^^^ Messenger RNA levels were highest at 25 min following infusion of N methyl DL aspartate . c jun messenger RNA levels remained elevated for over 2 h ; however , c fos , junB and , NGFI A messenger RNA levels had returned to control levels by this time . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As OA did not synergize with PMA in the induction of expression of genes encoding the AP 1 proteins ( c fos , c jun , junB ) , it is likely that OA potentiates the AP 1 enhancer activity by its effect on protein phosphorylation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By 7 weeks post lesion there was still evidence of c Jun immunoreactivity in both large and other clearly atrophic rubrospinal neurons . c Fos immunoreactivity was seen only at 12 48 h in a small number of rubrospinal neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recent studies show that chemical induction of glutathione S transferase Ya and quinone reductase gene expression is associated with an induction of c fos and c jun gene expression and AP 1 binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Initiation of transcription of most matrix metalloproteinase genes requires binding of the transcription factor AP 1 ( c jun / c fos ) to a specific promoter sequence but attainment of maximal transcription rates is dependent on interaction with other promoter elements as well . ^^^ Proinflammatory cytokines and growth factors induce signalling pathways several of which are dependent on protein kinase C and result in transient expression of the transcription factors c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study involved detecting p 39 c JUN and p 55 c FOS , as well as two oncoproteins previously known to be expressed during colorectal tumorigenesis , p 21 RAS and the tumor suppressor protein , p 53 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Evidence for enhanced expression of c fos , c jun , and the Ca ( 2+ ) activated neutral protease in rat liver following carbon tetrachloride administration . ^^^ The effects of CCl 4 on hepatic c fos and c jun gene expression were examined , and the correspondence between intermediate early gene expression and the expression of the Ca ( 2+ ) activated neutral proteinase ( mu and mCANP ) characterized . ^^^ Administration of CCl 4 to rats resulted in a pronounced dose and time dependent increase in c jun and c fos mRNA levels ( approximately 8 to 17 fold ) as detected by either Northern blot or RT PCR analyses . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Basal levels of c myc were comparable for all three cell lines , but levels of c jun and c fos were elevated 2 to 4 fold in VP 16 resistant cell lines . ^^^ Increased levels of c fos and c jun were not a result of altered rates of transcription , as determined by nuclear run off assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 complexes , formed by c fos and c jun which bind to 5 ' residues of the MMP genes , seem causally related to MMP gene expression in response to PMA . ^^^ AP 1 complexes , formed by c fos and c jun which bind to 5 ' residues of the MMP genes , seem causally related to MMP gene expression in response to PMA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These data demonstrate that in contrast to c jun , c fos is transiently increased in both cardiac muscle and adipose tissue by insulin treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the immediate early gene encoded proteins c Jun , Jun B , Jun D , c Fos , Fos B and Krox 24 in central neurons following transection of , or inhibition of , axonal transport in their axons was investigated in the rat using immunocytochemistry . ^^^ The other immediate early genes , Jun B , c Fos and Fos B , were never expressed above the basal levels seen in untreated rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , GIP alone induced the transcription of c jun mRNA ; however , in combination with IL 6 , it stimulated de novo synthesis of DNA and the transcription of both c jun and c fos genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunocytochemistry with specific antisera was used to assess regional levels of six IEG encoded proteins ( c Fos , Fos B , Krox 24 , c Jun , Jun B , Jun D ) in the rat forebrain after kainic acid induced limbic seizures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Presence and possible role of c ras and nuclear ( c fos and c jun ) proto oncogene products in preimplantation embryonic development in mice . ^^^ The presence and possible role of products of nuclear ( c fos and c jun ) and c ras proto oncogenes were investigated in preimplantation embryonic development in mice . ^^^ Polyclonal antibodies to c fos or c jun proto oncogene products did not affect development of in vitro cultured embryos from two cell to morula or from morula to late blastocyst stages . ^^^ Neither c fos nor c jun antibodies reacted with specific proteins corresponding to c fos ( 62 kDa ) and c jun ( 39 kDa ) products on the Western blots of various murine ova / embryos extracts . ^^^ However , the c fos and c jun antibodies reacted with 62 and 39 kDa protein bands , respectively , on the blot of NIH 3T3 cells extract . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Chem . 264 , 3538 3544 ] , chronic ( 24 h ) treatment with bryostatin blocked the formation of neurites in response to NGF or basic fibroblast derived growth factor stimulation , but , like PMA , bryostatin did not block the induction of c fos or c jun protooncogenes by NGF . ^^^ The bryostatin sensitive protein kinase C is necessary , but not sufficient , for neurite outgrowth and acts in the nucleus in a manner independent of c fos and c jun transcription . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Anisomycin and rapamycin define an area upstream of p70 / 85S6k containing a bifurcation to histone H 3 HMG like protein phosphorylation and c fos c jun induction . ^^^ Anisomycin , a translational inhibitor , synergizes with growth factors and phorbol esters to superinduce c fos and c jun by a number mechanisms , one of which is its ability to act as a potent signalling agonist , producing strong , prolonged activation of the same nuclear responses as epidermal growth factor or tetradecanoyl phorbol acetate . ^^^ Ablation of epidermal growth factor , tetradecanoyl phorbol acetate , or anisomycin stimulated S 6 phosphorylation by using the p70 / 85S6k inhibitor rapamycin has no effect on histone H 3 and HMG like protein phosphorylation or on the induction and superinduction of c fos and c jun . ^^^ These results suggest the possible use of anisomycin and rapamycin to define upstream and downstream boundaries of an area of signalling above p70 / 85S6k which contains a bifurcation that produces histone H 3 HMG like protein phosphorylation and c fos c jun induction in the nucleus . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using antibodies specific for different Ets and AP 1 family members , we demonstrate that the major inducible PB 1 binding activity present in activated T cell nuclear extracts is composed of the Elf 1 , c Fos , and JunB transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ATFa / c Jun heterodimers , but not the ATFa / c Fos complexes , bind efficiently to ATF , CRE or AP 1 sites . ^^^ We also show that coexpression of ATFa with c Jun , Jun B or Jun D stimulates ATFa dependent reporter activity , while coexpression of c Fos has no effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We present evidence that chemical agents induce expression of c fos and c jun proto oncogenes and an enhanced synthesis of protein components of AP 1 complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Binding of interleukin 2 ( IL 2 ) to the IL 2 receptor ( IL 2R ) stimulates Src family kinases , tyrosine phosphorylation of several proteins , conversion of Ras to its active GTP bound form , and eventually c fos , c jun , and c myc induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of several second messenger pathways induces the expression of immediate early genes such as c fos , c jun , junB , and junD , but little is known about their induction via the stimulation of the cyclic GMP pathway . ^^^ We found that expression of c fos and junB but not of c jun or junD is increased upon activation of cyclic GMP pathway . c fos mRNA expression was the most activated ( fourfold at 30 min ) , whereas junB response was more modest ( 2 . 2 fold activation at 60 min ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increases in mRNA levels for c fos , c jun , junB , hsp 70 and NGFI A were observed in the dentate gyrus of the hippocampus following 7 min ischaemia in the Mongolian gerbil . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos , c jun , c ras , c erbB 1 , c neu and c myc at the protein level was investigated by immunohistochemistry . ^^^ Tumors with an ( over ) expression of the proteins encoded by the oncogenes c fos , c jun , c erbB 1 and c ras had a significantly higher take rate in nude mice than tumors without an ( over ) expression of the oncogene products . ^^^ Interestingly , only patients with tumors with an ( over ) expression of the proteins encoded by the oncogenes c fos , c jun , c erbB 1 and c ras had significantly shorter survival times than patients whose tumors did not show an ( over ) expression of the oncogene products . ^^^ These results demonstrate that the aggressiveness of the tumors visible in the higher take rate of the tumors in nude mice and in the shorter survival times of patients can be detected by measurement of the expression of c fos , c jun , c erbB 1 and c ras at the protein level . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The second pathway , which leads to activation of c fos and c jun genes , is only partially sensitive to herbimycin , is resistant to genistein and depends on the region between amino acid positions 626 and 763 of the beta subunit . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNA protein interaction studies , together with mRNA and protein analyses , indicate that c Jun , but not c Fos , is involved in OA dependent uPA gene induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 , Pefabloc TPA , diisopropyl fluorophosphate or alpha 1 anti trypsin inhibit the mitogenic effect of t PA for smooth muscle cells in a dose dependent manner , showing that it is dependent on the enzymatic activity . t PA activated phosphoinositide turnover in smooth muscle cells through a pertussis toxin insensitive pathway and stimulated proto oncogene c fos and c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There were very early increases in the expression of c fos and c jun , reflecting the mitogenic response to refeeding that occurs within the crypt compartment . ^^^ Studies using the protein synthesis inhibitor cycloheximide suggest that c fos and c jun are part of the `` immediate early ' ' response of the small intestine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
OBJECTIVE AND DESIGN : The immediate early gene locus AP 1 , incorporating the cellular oncogenes c fos and c jun ( and their oncoprotein products Fos and Jun respectively ) play a key role in regulating cell growth and differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Estradiol increases and anti estrogens antagonize the growth factor induced activator protein 1 activity in MCF 7 breast cancer cells without affecting c fos and c jun synthesis . ^^^ The growth factor induced AP 1 response was increased by estradiol and inhibited by anti estrogens in conditions where growth factor induced c fos and c jun mRNA levels were unchanged by hormone and anti hormone treatments . ^^^ The same regulations were obtained when the AP 1 response was directly induced by co transfection of c fos and c jun expression vectors . ^^^ We conclude that in conditions where c fos and c jun syntheses were not affected , the estrogen receptor cooperated with growth factors to stimulate the AP 1 response when activated by estrogens but inhibited AP 1 mediated transcription when occupied by anti estrogens . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The antiestrogen tamoxifen induces c fos and jun B , but not c jun or jun D , protooncogenes in the rat uterus . ^^^ The purpose of the present study was to investigate the effect of tamoxifen on activation of the c fos , c jun , jun B and jun D protooncogenes in rat uteri in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c jun gene is expressed constitutively and both IL 2 and phorbol esters induce the expression of c fos to generate a functional AP 1 capable of repressing cell death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Following in vitro culture , a transient but profound increase in c fos , c jun , TNF alpha and IL 1 beta mRNA levels was observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The phorbol ester , 12 O tetradeconoylphorbol 13 acetate ( TPA ) , can not support growth of these cells , is a more effective inducer than insulin of c fos , c myc , c jun , jun B , Krox 20 , Krox 24 , fra 1 and JE , and induces fra 1 , JE and c myc with different kinetics from those of insulin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Therefore , the early response of the skin to high doses of radiation might involve heterodimeric activator protein 1 composed of c Fos and c Jun proteins . ^^^ Preferential induction of c fos versus c jun protooncogene during the immediate early response of pig skin to gamma rays . ^^^ The involvement of the nuclear protooncogenes c fos and c jun in the immediate early response of pig dermis cells was studied after in vivo gamma irradiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recent observations implying reactive oxygen as the transduction signal that mediates activation of c fos and c jun genes are presently considered to provide an explanation for the induction of GST gene expression by chemical agents of diverse structure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of expression of genes encoding components of AP 1 transcription factor ( c fos , c jun and their cognates ) as well as AP 1 itself has been repeatedly shown to coincide with long term cellular responses . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , RNA blot analysis showed that overexpression of wild type PKC but not of the COOH terminal mutant enhances phorbol ester induction of c FOS and c JUN mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This phenotype is specific for c fos as transgenic mice expressing the fos and jun related genes , fosB and c jun , from the same regulatory elements do not develop any pathology despite high expression in bone tissues . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We now report , that RA synergistically enhances the induction of c fos , but not c jun mRNA by PMA in cells whose growth was stimulated by RA alone . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the adult animal , the immediate early genes such as c fos and c jun , and other activity dependent genes such as ornithine decarboxylase ( ODC ) are induced within minutes to hours in response to perturbations to the cellular environment . ^^^ In the neonatal ( PND 4 ) rat hippocampus , the basal expression of c fos , c jun , and ODC appeared to be unaltered following TMT exposure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear levels of c Jun , JunB , c Fos , and LRF 1 ( liver regeneration factor ) are high for a large fraction of the G 1 phase in regenerating liver and mitogen stimulated hepatic cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Depolarization induces c fos and jun B but not c jun ; however , growth factors such as NGF can induce all three genes in the same cell ( Bartel et al . 1989 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The trans acting factor AP 1 is a heterodimeric complex composed of c Jun and c Fos family proteins which bind and regulate genes containing a TPA responsive enhancer element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study we have investigated in bovine adrenal cells ( BAC ) the effects of basic fibroblast growth factor ( b FGF ) , insulin like growth factor 1 ( IGF 1 ) and transforming growth factor beta ( TGF beta ) on c jun , jun B and c fos mRNA levels and on cell growth and differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using promyelocytic HL 60 cells , we have observed an exquisite sensitivity to Ca2+ of c fos , c jun , and zif 268 mRNA accumulation , since early and maximal inductions were observed at 200 300 nM [ Ca2+ ] 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNAs encoding c Fos , c Jun , Jun D , and Jun B were induced within 1 h of exposure to hypoxia , increased 5 10 fold between 1 and 4 h and then declined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have used the evoked expression of both immediate early gene ( IEG ) encoded proteins ( Krox 24 , c Fos , Fos B , Jun D , Jun B , c Jun ) , and dynorphin to monitor sensory processing in the spinal cords of rats undergoing subacute or chronic somatic inflammation ( i . e . , subcutaneous inflammation of the plantar foot and monoarthritis , respectively ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the nuclear c JUN , JUN B , JUN D , c FOS , FOS B , KROX 24 , and CREB transcription factors was investigated in the cortex of adult rats by immunocytochemistry . ^^^ Following KCl or BIC , a strong induction was seen for c FOS , JUN B , and KROX 24 , whereas c JUN , JUN D , and FOS B showed only a moderate increase compared to basal levels . ^^^ In untreated rats , JUN B , c FOS , and FOS B were expressed in a small number of neurons in the piriform , perirhinal , entorhinal , and insular cortex and in layers 2 , 3 , and 6 of all neocortical areas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we show that the induction of the uPA gene by CSR is mediated by the activation of c Jun which interacts with an AP 1 like site located 2 kb upstream of the uPA gene . 12 O tetradecanoylphorbol 13 acetate ( TPA ) induces the uPA gene through the same elements , but additionally utilizes an adjacent PEA 3 element and induces c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear run on transcription and / or Northern blot RNA analysis indicate that c jun , junB , jun D , c fos , TIS 1 ( also called NGFI B or nur / 77 ) and TIS 8 ( zif 268 , krox 24 , egr 1 , or NGFI A ) genes are all transiently activated in the uterus ( up to 20 fold ) within 30 120 min after treatment of adult ovariectomized rats with a mitogenic dose of 17b estradiol . ^^^ Stimulation in the presence of cycloheximide shows that only c jun , jun D , c fos , and JE gene activations are primary responses to the hormone in rat uterine cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ang 2 caused a rapid induction of many immediate early genes ( c fos , c jun , jun B , Egr 1 , and c myc ) in myocyte and nonmyocyte cultures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To this end , we have shown that both c Fos and c Jun are expressed in neuroendocrine neurons in response to a number of stimuli , setting the stage for potential regulatory drive to genes containing AP 1 binding sites . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c fos and c jun proto oncogenes encode components of the transcription factor AP 1 . ^^^ To determine whether transformation by the 5 fos or 5 jun oncogene results in alterations in the level or regulation of this factor , we have characterized AP 1 DNA binding activity in nuclear extracts prepared from 5 fos and c fos transformed rat fibroblast cell lines and 5 jun transformed chicken embryo fibroblasts under various growth conditions . ^^^ During proliferation , the level of AP 1 DNA binding activity does not differ among the 5 fos , c fos , or 5 jun transformed cells and their normal progenitors , despite constitutive overexpression of the corresponding oncoproteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The goal of this study was to compare the response of mouse epidermal keratinocytes ( MEKs ) and human epidermal keratinocytes ( HEKs ) to 12 O tetradecanoylphorbol 13 acetate ( TPA ) with respect to the activation and downregulation of protein kinase C ( PKC ) , the expression of c jun and c fos , and the expression and induction of ornithine decarboxylase ( ODC ) activity . ^^^ After treatment with TPA , MEK cultures produced a large induction of both c jun and c fos mRNA by 60 min , as determined by northern blot analysis , and a large induction of ODC mRNA and enzyme activity by 6 h . ^^^ Northern blot analysis also revealed no increase in c jun , c fos , and ODC mRNA in HEKs . ^^^ However , c jun and c fos mRNA and both ODC mRNA and enzyme activity were induced in HEKs fed growth factors after several days of deprivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that the reconstituted hGM CSFR transduces signals in NIH3T3 fibroblasts and BA / F3 cells in response to human GM CSF to activate transcription of c fos , c jun and c myc protooncogenes . hGM CSF also induces protein tyrosine phosphorylation and DNA synthesis in both cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The commitment stage towards PMA induced macrophage differentiation was associated with increases in jun B and c fos mRNA levels , as well as with an increase in the binding activity of transcription factor AP 1 . ^^^ Furthermore , addition of sodium butyrate or 1 alpha , 25 dihydroxyvitamin D 3 to HL 60 cells induced the expression of c fos , c jun , jun B and jun D proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In accordance with this delay , the induction of mRNA level of ' immediate early genes ' such as c myc , c fos , c jun and junB by TGF beta has slower kinetics compared with those of EGF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro transcribed and translated c Fos and c Jun bound to both the AP 1 site and to the sequences from 182 to 141 . ^^^ DNAase 1 footprinting of the collagenase promoter with purified c Jun or c Fos / c Jun protected the AP 1 sequence at 77 to 69 in addition to a region from 189 to 178 which overlaps a putative AP 1 like site , 5 ' ATTAATCAT 3 ' . ^^^ Thus , we have identified a novel phorbol responsive region that binds c Fos and c Jun , and we suggest that these or similar proteins may regulate transcription of the collagenase gene by binding to sequences within and adjacent to the 182 to 161 region . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The experimental findings of this paper demonstrated that the induction of `` Immediate Early Genes ' ' genes c fos , c jun and zif / 286 occurs in the nervous system of various animal species in the situations of learning and environmental novelty . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Decreased expression of protooncogenes c fos , c myc , and c jun following polyamine depletion in IEC 6 cells . ^^^ This study tests the hypothesis that the protooncogenes c fos , c myc , c jun , and junB are involved in the mechanism by which polyamines modulate mucosal growth . ^^^ Cellular polyamine levels , cell growth , and relative abundance of c fos , c myc , c jun , and junB mRNAs , were measured at 1 , 2 , 4 , 6 , 8 , and 12 days after initial plating . ^^^ In control cells , c myc and c jun mRNA levels significantly increased on days 4 6 and then returned to a basal level of expression , which was maintained thereafter . c fos mRNA in quiescent cells after 24 h serum deprivation was significantly stimulated by 5 % dFBS , although a steady state level of c fos mRNA was undetectable in control cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report here that mRNA levels for nuclear protooncogenes c myc , c fos , and c jun increase dramatically in both sexes from little or no detectable expression on day 12 to high expression on days 13 15 . ^^^ Our results are consistent with a role for protooncogenes c myc , c fos and c jun in mediating the initial differentiation of PGCs of both sexes that occurs upon colonization of the gonad . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that mRNA levels for the subunits that compose AP 1 , the protooncogenes c fos and c jun , are upregulated by stimulation of THP 1 cells with TSST 1 . ^^^ These results establish that the engagement of MHC class 2 molecules by superantigens increases the activity of functional AP 1 complexes and that this may proceed in part by transcriptional activation of c fos and c jun protooncogenes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of beta adrenergic receptors by isoproterenol or addition of 8 BrcAMP rapidly and transiently induces the expression of the protooncogenes , c fos , and jun B , but not that of c jun in A 5 cells . ^^^ The inducibility of c fos and jun B genes by either isoproterenol of 8 BrcAMP is transcriptionally regulated and accompanied by increases in their respective products . ^^^ Furthermore , both c fos and jun B mRNA levels are elevated at G0 / G1 phase of the A 5 cell cycle and are inducible by isoproterenol or 8 BrcAMP at the different phases of the cell cycle . ^^^ These data further suggest a possible role of c fos and jun B in A 5 cell cycle . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since previous studies have demonstrated that components of the AP 1 transcription factor can modulate glucocorticoid receptor activity in other systems , we examined the regulation of the proto oncogenes c fos and c jun in response to CRF . ^^^ Treatment of the corticotrope cell line ( AtT 20 ) with CRF rapidly activated c fos mRNA to levels 11 12 fold above control by 30 and 60 min , with no apparent elevation of c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that incubation with 100 nM methylcarbamoyl PAF , a nonhydrolyzable analog of PAF , produced rapid transient 2 . 8 and 3 . 5 fold increases in the expression of c fos and c jun , respectively , at 1 hr , followed by increased expression of the collagenase type 1 gene beginning at 3 hr and peaking at 14 fold by 8 hr . ^^^ Addition of the protein synthesis inhibitor cycloheximide superinduced c fos and c jun , strongly potentiating the PAF effect , but inhibited the induction of collagenase type 1 expression , suggesting the existence of a transcriptional factor linking the two events . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The times of appearance of Cd ( 2+ ) induced c fos , c myc and c jun expression are dose dependent . ^^^ These results suggest that Cd2+ acts through one or more defined signal transduction pathways involving specific protein kinases C to induce the accumulation of c fos , c myc and c jun messenger RNAs . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Elevated mouse c fos protein expressed from a cotransfecting plasmid pRSVfos or human c jun protein expressed from RSVjun led to 2 . 1 fold and 3 . 1 fold stimulation of the activity of the hCRH promoter . ^^^ Tetradecanoyl phorbol 13 acetate stimulated the c fos and c jun transactivation by a factor of 10 and 2 . 6 , indicating a modification of c fos and c jun is required for the transactivation induced by protein kinase C activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of both c jun and c fos expression vectors with the INV CAT vector into FRSK cells resulted in increased CAT activity . ^^^ Cotransfection of either the c jun or c fos vector singly with the INV CAT vector into FRSK cells had negligible effects . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Manidipine inhibits endothelin 1 induced [ Ca2+ ] 1 signaling but potentiates endothelin ' s effect on c fos and c jun induction in vascular smooth muscle and glomerular mesangial cells . ^^^ In contrast , manidipine ( 10 ( 5 ) mol / L ) potentiated ET 1 induced c fos and c jun expression in A7r5 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Divergent effects of arginine vasopressin and angiotensin 2 on proliferation and expression of the immediate early genes c fos , c jun and Egr 1 in cultured rat glomerular mesangial cells . ^^^ To elucidate the level of signal divergence , we examined the effects of AVP and Ang 2 on the expression of the immediate early genes c fos , c jun and Egr 1 , which have been associated with cell growth . ^^^ Messenger ( m ) RNA levels of c fos , c jun Egr 1 and ornithine decarboxylase were determined by Northern blot analysis . ^^^ The relative increases were : c fos , 15 fold ; c jun , 12 fold ; Egr 1 , sixfold . ^^^ CONCLUSIONS : The results demonstrate that AVP , but not Ang 2 , is a strong inducer of the immediate early genes c fos , c jun and Egr 1 in cultured mesangial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear runoff transcription studies showed that the kinetics of induction of this gene is almost identical to that of protooncogene c jun or c fos , the known early growth response genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The persistent induction of AP 1 transcription factors by asbestos suggests a model of asbestos induced carcinogenesis involving chronic stimulation of cell proliferation through activation of the early response gene pathway that includes c jun and / or c fos . . ^^^ Persistent induction of c fos and c jun expression by asbestos . ^^^ To investigate the mechanisms of asbestos induced carcinogenesis , expression of c fos and c jun protooncogenes was examined in rat pleural mesothelial cells and hamster tracheal epithelial cells after exposure to crocidolite or chrysotile asbestos . ^^^ In contrast to phorbol 12 myristate 13 acetate , which induces rapid and transient increases in c fos and c jun mRNA , asbestos causes 2 to 5 fold increases in c fos and c jun mRNA that persist for at least 24 hr in mesothelial cells . ^^^ The induction of c fos and c jun mRNA by asbestos in mesothelial cells is dose dependent and is most pronounced with crocidolite , the type of asbestos most pathogenic in the causation of pleural mesothelioma . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The C terminal topo 2 fragment also interacted with full length c Jun , but not with full length c Fos . ^^^ This stimulatory effect could also be elicited by c Jun , which interacts with topo 2 , but not by c Fos , which does not bind topo 2 in our in vitro assay . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The presence of c fos had a negative influence on GR function and correlated with the cell specific synergistic or antagonistic activity of Jun with respect to GR ; high basal expression of c fos as well as AP 1 DNA binding and transcriptional activity were observed in HeLa cells , but not in T cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Non small cell lung carcinoma specimens of 173 previously untreated patients were analyzed for the expression of proteins encoded by the oncogenes c myc , c fos , c jun , c erbB 1 , c erbB 2 , c H ras , c K ras and c N ras . ^^^ Forty six per cent of the tumors were positive for the c MYC protein , 60 % for c FOS , 50 % for c JUN , 80 % for c ERBB 1 , 55 % for c ERBB 2 , 12 % for c H RAS , 5 % for c K RAS and 71 % for c N RAS . ^^^ Proteins encoded by c fos and c jun are overexpressed more frequently in carcinomas of smokers ( c fos : P < 0 . 005 ; c jun : P < 0 . 01 ) . ^^^ Squamous cell lung carcinomas of smokers showed a higher incidence of c FOS ( P = 0 . 01 ) , c JUN ( P < 0 . 01 ) and c ERBB 1 ( P = 0 . 01 ) proteins than squamous cell lung carcinomas of non smokers . ^^^ In adenocarcinomas , however , we only found a trend for a more frequent overexpression of c fos ( P = 0 . 07 ) and c jun ( P = 0 . 14 ) encoded proteins in carcinomas of smokers and no correlation between the expression of c erbB 1 products and smoking . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Remarkably , we observed that these samples displayed a persistent expression of the c fos protooncogene , associated to an increased AP 1 DNA binding activity , whereas no variations of CREB or NF kB were detected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This effect is associated with acid induced increases in a number of immediate early genes , including c fos , c jun , junB , and egr 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of murine c Fos or c Jun expression plasmids with the FIV LTR CAT reporter plasmid into fcwf 4 cells revealed that FIV LTR could be activated by c Fos but not c Jun in the cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although electrophoretic mobility shift assays indicate that the rat quinone reductase ARE does not contain a high affinity recognition site for in vitro translated c Jun and c Fos , 12 O tetradecanoylphorbol 13 acetate can act as an inducer through the ARE sequence in Hep G 2 cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The essential sequence in the JE 1 element for the binding of nuclear factors was found to be TTACTCA . c fos and c jun proteins synthesized in vitro could bind to the DNA fragment containing this sequence , but the binding was weaker than to the TPA responsive element ( TGACTCA ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results demonstrate that , in contrast to U 937 cells , the TUR line fails to respond to TPA with induction of the c jun , junB , c fos , and EGR 1 early response genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thyrotropin releasing hormone stimulates c jun and c fos messenger ribonucleic acid levels : implications for calcium mobilization and protein kinase C activation . ^^^ To characterize the gene proximal elements of the intracellular signaling pathways involved , we examined the effects of TRH , ionomycin , and phorbol ester ( TPA ) on cellular protooncogenes ( c jun and c fos ) known to be responsive to calcium mobilization and protein kinase C activation . ^^^ TRH stimulated a 3 fold increase in both c jun and c fos mRNA levels within 1 h , followed by a rapid decline in steady state mRNA levels . ^^^ The increase in c jun and c fos mRNA levels occurred before the increased steady state mRNA levels of both PRL and TSH beta chimera in transfected pituitary GH 3 cells . ^^^ Our data indicate that calcium mobilization and protein kinase activation represent distinct components of the signaling events initiated by TRH resulting in increased c jun and c fos mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In both human K 562 myelogenous leukemia and rat PC 12 pheochromocytoma cells , activin treatment caused transient transcription dependent and protein synthesis independent increases of junB messenger RNA ( mRNA ) within 1 h , whereas neither c jun nor c fos mRNA were inducible . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Similarly , the AP 1 transcription factor complex is comprised of dimers of the c fos and c jun proto oncogene products or of closely related proteins . ^^^ We now demonstrate that the bZIP regions of c Fos and c Jun are capable of physically interacting with NF kappa B p 65 through the Rel homology domain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The supershift assays using antibodies against specific proteins of the AP 1 family identified Jun D and c Fos as two members in the hARE protein complex observed in band shift assays . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While differentiating myoblasts are withdrawn from the cell cycle , myogenesis is inhibited by some mitogens and overexpression of some oncogenes , including proto oncogene c fos ( which expresses a growth associated protein constituting the regulatory factor AP 1 in conjunction with c Jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have used the evoked expression of the immediate early gene encoded proteins ( Krox 24 , c Fos , Fos B , Jun D , Jun B , c Jun ) to monitor visceral processing in both the spinal cord and hindbrain structures of rats undergoing either mechanical colorectal or chemical intraperitoneal stimulation . ^^^ Non nociceptive and nociceptive stimulation but not anaesthesia were effective in evoking c Fos , c Jun , Jun B and Krox 24 expressions in the spinal cord . ^^^ Krox 24 and , to a lesser degree , c Jun labelled cells were quite numerous in the superficial layers of the dorsal horn ; Jun B , and especially c Fos , were very effective in demonstrating inputs to all parts of the spinal cord . ^^^ Both anaesthesia and noxious visceral stimulation were effective in evoking c Fos , Krox 24 and Jun B expressions in discrete hindbrain subregions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos , c jun , jun B , and NGFI A mRNA are rapidly induced in cultured astrocytes after treatment with phorbol ester , epidermal growth factor , and basic fibroblast growth factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The PML RAR alpha chimera cooperates with c Jun and , strikingly , with c Fos to stimulate the transcription of both synthetic and natural reporter genes containing an AP 1 site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
K+ channel openers prevent global ischemia induced expression of c fos , c jun , heat shock protein , and amyloid beta protein precursor genes and neuronal death in rat hippocampus . ^^^ Transient global forebrain ischemia induces in rat brain a large increase of expression of the immediate early genes c fos and c jun and of the mRNAs for the 70 kDa heat shock protein and for the form of the amyloid beta protein precursor including the Kunitz type protease inhibitor domain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mobility shift data reveal that the complement of c Fos and c Jun proteins which bind to the fos AP 1 octanucleotide decrease immediately following irradiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this work we investigated c fos and c jun gene expression and AP 1 ( 12 O tetradecanoylphorbol 13 acetate ) responsive enhancer element ( TRE ) binding activity during keratinocyte differentiation utilizing both authentic and in culture reconstituted human epidermis . ^^^ Increased levels of c fos and c jun expression have been observed in differentiating epithelial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the rat hippocampus , jun , c fos , and fos related antigen immunoreactivity , AP 1 DNA binding , and opioid peptide gene expression were examined after kainate treatment to determine whether the induction and DNA binding of AP 1 transcription factors are correlated with the expression of the opioid peptide genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This observation led to the speculation that these proto oncogenes , particularly c fos and c jun , might act as positive regulators of cardiac transcription . ^^^ We have examined the role of c jun and c fos in basal and growth stimulated cardiac transcription , using the cardiac specific atrial natriuretic factor ( ANF ) gene as a marker . ^^^ The results indicate that c jun and c fos are negative regulators of ANF transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate whether estrogen treatment of hormone responsive human breast cancer cells was associated with activation of members of the jun family of immediate early response genes , the expression of these oncogenes in human breast cancer cells was examined . 17 beta Estradiol had little effect on expression of c jun , jun B , jun D , or c fos mRNA by MCF 7 cells over 12 h , although it stimulated c myc expression 4 fold within 30 min . ^^^ In contrast , several peptide growth factors , including transforming growth factor alpha ( TGF alpha ) , rapidly and transiently induced expression of c jun , jun B , and c fos mRNA 4 to 10 fold over control . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since we previously found that activation of mast cells by IgE antigen ( Ag ) induces the mRNA accumulation of c fos , c jun , junB and junD proto oncogenes , we were prompted to investigate whether serum could affect such accumulation in these cells . ^^^ After sustained FCS deprivation both DNA synthesis and the level of c fos mRNA were significantly decreased , as expected , whereas the level of c jun , junB and junD mRNA were not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of pulsatile and steady fluid flow on the mRNA levels of proto oncogenes c fos , c jun , and c myc in cultured human umbilical vein endothelial cells ( HUVEC ) were investigated . c fos mRNA levels in stationary cultures were very low . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 4 inhibits the lipopolysaccharide induced expression of c jun and c fos messenger RNA and activator protein 1 binding activity in human monocytes . ^^^ We studied the effect of interleukin 4 ( IL 4 ) on the lipopolysaccharide ( LPS ) induction of two immediate early genes c fos and c jun . ^^^ Maximal accumulation of either c fos and c jun messenger RNA ( mRNA ) occurred 30 minutes after LPS addition . ^^^ When cells were treated with IL 4 for 5 hours before LPS activation , both the c fos and the c jun mRNA expression was decreased . ^^^ The inhibition of c fos and c jun expression by IL 4 in LPS treated cells was shown to be due to a lower transcription rate of the c fos and c jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes c jun , junB , junD , and c fos recently have been shown to encode for transcription factors with a leucine zipper that mediates dimerization to constitute active transcription factors ; juns were shown to dimerize with each other and with c fos , whereas fos was shown to dimerize only with juns . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study examined by immunohistochemistry , using specific antibodies , the distribution of stromelysin , IL 1 alpha , IL 1 beta , and oncogene products ( c FOS , c JUN , and c MYC ) in synovium and cartilage from normal and experimental canine models of OA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increases in c jun , jun B , and jun D mRNA levels also occurred in both models at times similar to the rises of c fos and c myc expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
With the same probe , we could detect the induction of c jun mRNA ( as well as that of c fos and jun B mRNAs ) in the hippocampus following administration of pentylenetetrazol . ^^^ Coordinate expression of c fos and jun B is induced in the rat striatum by cocaine . ^^^ We found by Northern blot and in situ hybridization analysis that cocaine induces the coordinate expression of c fos and jun B mRNAs in neurons of the rat ' s striatum . ^^^ The induction of expression of c fos and jun B was rapid and transient , with peak expression occurring at approximately 1 hr after cocaine administration , and the induction of the two genes was in similar striatal sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using a seasonal breeder , the European red fox ( Vulpes vulpes ) , as our model , we have examined the expression of five AP 1 family members ( c fos , fra 1 , fra 2 , c jun and junB ) with a view to elucidating their role in the regulation of spermatogenesis . ^^^ The products of two proto oncogenes , c fos and c jun , have been implicated in signal transduction pathways as regulators of gene expression . ^^^ Unique patterns of expression , falling into three broad categories , were observed for the five genes : ( 1 ) continuous expression throughout the spermatogenic cycle ( c fos ) ; ( 2 ) expression only at times corresponding to the onset and shutdown of spermatogenesis ( fra 1 , fra 2 and c jun ) ; and ( 3 ) expression only at the onset of the cycle ( junB ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When rat neonatal cardiac myocytes maintained in culture were incubated with myotrophin for 30 minutes , they showed a marked increase in c myc , c fos , and c jun messenger RNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transfection of a T3R expression vector , however , resulted in a 70 % inhibition of expression by T 3 , which was abolished by cotransfection of c jun and c fos expression vectors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have tested this approach by using c Fos and c Jun as our model system . ^^^ Further , complexes containing c Jun and c Fos can also be isolated in this manner , and the isolation of this complex is dependent on the presence of c Fos , c Jun , avidin , and the BCCP moiety . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Elevated binding activity of AP 1 also correlated with elevated levels of c jun , junD , junB , and c fos mRNAs . ^^^ Western blots showed elevated hepatic levels of c Jun but not c Fos proteins during the acute phase response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Temporal and spatial patterns of expression of c fos , zif / 268 , c jun and jun B mRNAs in rat brain following seizures evoked focally from the deep prepiriform cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This phenomenon reflects an enhancement of the cellular pool of NGF mRNA , already noticeable after 3 h of treatment , which is preceded by a temporary activation of protooncogenes encoding transcription factors of the AP 1 family , such as c fos , c jun or junB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have investigated the effect of electroporation on the expression of collagen alpha 1 ( 1 ) , collagenase , c fos and c jun genes in human dermal fibroblasts ( HDF ) , human smooth muscle cells ( HSMC ) and HeLa cells . ^^^ Neither collagen nor collagenase mRNAs were detected in control or electroporated HeLa cells . c fos and c jun mRNA levels were also increased in electroporated HDF , HSMC and HeLa cells harvested 1 h after plating . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that the reconstituted hGM CSFR transduces signals in NIH 3T3 fibroblasts and BA / F3 cells in response to hGM CSF to activate transcription of the c fos , c jun , and c myc proto oncogenes . hGM CSF also induces protein tyrosine phosphorylation and DNA synthesis in both cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The use of specific monoclonal antibodies indicated that in all cases c Jun and c Fos or antigenically related proteins were required for binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The increase in nuclear protein binding following irradiation was specific for the AP 1 sequence and was reduced by antibodies to c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hence , we developed a general approach in which proteins can be individually expressed but interact specifically through the leucine zippers of c Jun and c Fos fused to each protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the c jun , c fos , and NGFI A genes was studied in the rabbit retina after optic nerve crush ( ONC ) or an intravitreal injection of colchicine . ^^^ By Northern blotting , the basal expression of c fos and NGFI A mRNAs were undetectable , whereas c jun mRNA showed a low basal expression in sham operated control retinas . ^^^ Northern blots demonstrated that retinal levels of c jun mRNA , but not of c fos or NGFI A mRNAs , were increased 3 and 7 days after ONC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
B cell development is perturbed in bone marrow from c fos / v jun doubly transgenic mice . c fos and c jun gene products form a heterodimeric complex ( AP 1 ) that regulates target gene expression by binding to a specific DNA sequence motif . ^^^ In order to study a role of AP 1 ( Fos / Jun ) in growth and differentiation of immature B lineage cells , we have established and mated two independent transgenic mice carrying the mouse c fos gene or the viral 5 jun gene fused to the H 2K promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using transfection and reporter gene assays specifically designed for primary T lymphocytes in conjunction with gel retardation assays , Western blot analyses and UV cross linking studies , we found that c Jun , c Fos , and octamer binding proteins play a major role in transcriptional activation of the IL 3 gene via their interaction with two specific regions contained within the IL 3 5 ' flanking sequence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The purpose of this study was to examine the in vivo effect of Ang 2 on the renal expression of the early growth response genes c fos , Egr 1 and c jun . ^^^ Significant increases in the expression of the early growth response genes Egr 1 and c fos , but not c jun , were found in the Ang 2 infused left kidney compared to the control right kidney . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , this mutant protein blocks in vitro DNA binding of Jun Jun homodimers and Jun Fos heterodimers , transcriptional activation induced by c jun or c fos and transformation of rat embryo cells induced by an activated ras gene and a deregulated c jun or c fos gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blots were prepared from cortex , thalamus , cerebellum , pons and hypothalamus and hybridized with cDNA probes to five IEG mRNAs ; c fos , c jun , junB , NGFI A and NGFI B . ^^^ In contrast to c fos , c jun mRNA was essentially invariant among the animals while junB mRNA was inconsistently elevated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Correlation between lack of bone Gla protein mRNA expression in rat transplantable osteosarcomas and expression of both c fos and c jun proto oncogenes . ^^^ Alkaline phosphatase ( AP ) activity and expression of bone Gla protein ( BGP ) , c fos , and c jun were compared in two transplantable osteosarcomas with high potentials for metastasis to the lung . ^^^ Northern blot analysis revealed that lack of BGP mRNA expression was associated with expression of both c fos and c jun proto oncogenes in SOS . ^^^ In contrast , neither c fos nor c jun mRNAs were detected but BGP mRNA was expressed in the case of COS . ^^^ These results suggest that the c fos and c jun genes may suppress the expression of BGP mRNA relevant to differentiation and osteoid formation in rat osteosarcomas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the quiescent mouse BP A 31 fibroblasts , prostaglandin F 2 alpha ( PGF 2 alpha ) induces the expression of cell cycle related genes c fos , c jun , and c myc , and after a delay of approximately 12 h the entry into the phase of DNA replication . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dexamethasone induced a 20 fold increase in the level of c jun mRNA which was reversed after hormone withdrawal , whereas expression of c fos transcripts remained at a low level during the time course of hormone treatment and withdrawal . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear transcription of early activation genes ( c fos , c jun , and c myc ) as determined by nuclear run off assays , and steady state mRNA levels and / or protein products of intermediate activation genes ( IL 2 , IL 2R alpha , IL 2R beta , and transferrin receptor ) were not affected by TGF beta 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Enhanced IL 2 transcription correlates with increased c fos synthesis and increased Fos content of AP 1 . ^^^ We therefore examined the effects of EC on T cell nuclear factors known to regulate IL 2 transcription , including c jun and c fos two components of the transcription factor AP 1 , NFAT , and others . ^^^ Gel shift analysis reveals the constitutive presence of nuclear factors in resting PBL that bind to the proximal AP 1 site of the IL 2 promoter and that contain immunoreactive c Jun but not c Fos protein . ^^^ In contrast , AP 1 from PHA activated cells contains c Jun and low levels of c Fos . ^^^ Strikingly , costimulation with EC results in a dramatic increase ( up to 15 fold ) in the c Fos content of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study was designed to investigate the influence of intracellular ionized calcium ( [ Ca2+ ] 1 ) on the induction of c fos , c jun , c myc , and hsp 70 genes after oxidant stress induced by xanthine / xanthine oxidase ( X / XOD ) treatment or after heat shock using primary cultures of rat proximal tubule epithelium ( PTE ) . ^^^ These results suggest that cell injuries leading to increased [ Ca2+ ] 1 in PTE result in induction of c fos , c jun , c myc , and hsp 70 ; and that the activation of c fos and hsp 70 genes may be regulated by [ Ca2+ ] 1 and [ Ca2+ ] 1 dependent protein kinases . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To examine whether activation ( expression ) of nuclear proto oncogenes may play a role in hypertrophic cardiomyopathy , endomyocardial biopsies from 13 patients with hypertrophic cardiomyopathy were examined using monoclonal antibodies against c myc , c fos and c jun . ^^^ The nuclear proto oncogenes c fos , c jun and c myc were expressed in 53 , 60 , and 50 % , respectively , of patients with hypertrophic cardiomyopathy . ^^^ In control biopsies , c myc was detectable in only 10 % of the patients , while c fos and c jun were always undetectable . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since some of these differences may be relevant to the proliferation of SMC in atherosclerotic plaques we examined the expression of three proto oncogenes ( c fos , c jun , and c myc ) and an SMC specific differentiation marker ( alpha actin ) in cultured SMC . ^^^ Serum starved adult and neonatal SMC did not contain c fos or c jun transcripts , but in both cell types serum stimulation resulted in a comparable increase in the expression of both genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One pathway is linked to tyrosine phosphorylation events , mediated by a src family protein tyrosine kinase ( PTK ) , and that pathway leads to the induction of the c fos , c jun , and other genes of this family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several other well characterized and purified transactivators ( c Fos , c Jun , C / EBP , AP 2 , and Sp 1 ) have been shown to bind to the 221 / +33 region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We have studied the time course of the induction and the effects of cycloheximide treatment on the expression of c fos , c jun and the heat shock gene HSP 70 in ischemic reperfused livers ; extracts of these livers have also been examined for the binding to a synthetic oligonucleotide containing the heat shock consensus sequence ( HSE ) in order to reveal the possible presence of an active heat shock factor ( HSF ) in ischemic reperfused tissue . ^^^ RESULTS : Expression of HSP 70 gene appears only after a certain threshold of cell damage , is preceded by induction of c fos and c jun but does not depend on ongoing protein synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study analyses the effects of learning on the spatial pattern and the time course of changes of immediate early gene messenger RNA ' s ( c fos and c jun ) in mouse brain produced by training in an appetitive bar pressing task . ^^^ Activation of c fos and c jun after training is strictly located in the hippocampal formation and is learning dependent . ^^^ Injections of apamin , a bee venom neurotoxin that selectively blocks a class of Ca ( 2+ ) activated K+ channels and improves learning and memory retention , produced as compared to untrained animals a 3 to 5 fold increase of expression of c fos and c jun with the same pattern as that observed in the trained animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Indeed , we found that AP 1 is activated not only in proliferating but also in apoptotic cells , with a kinetics in accord with our data about c fos and c jun mRNA accumulation in the same experimental model . ^^^ We reported that in rat thymocytes , undergoing cell proliferation upon stimulation with Concanavalin A or cell death following dexamethasone treatment , an induction of c fos and c jun occurs with different but partially overlapping kinetics ( Grassilli et al . , BBRC , 1992 , 188 , 1261 1266 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Early response genes ( ERGs ) are a group of genes with low or absent expression in quiescent cells that can be induced rapidly by a variety of proliferation and differentiation stimuli . c jun and c fos are prototypes for this group of genes . ^^^ We therefore set out to explore the pattern of chemotherapeutic drug and radiation induced c jun and c fos expression in neuroectodermally ( astrocytic ) derived cell lines . ^^^ Finally , we have demonstrated that c fos and c jun expression and induction are discoordinately regulated , reflecting a difference in astrocytic cell lines compared to hematopoietic cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Accompanying this growth is the induction of the expression of growth related protooncogenes ( c fos , c jun , and c myc ) , as well as the synthesis of the autocrine growth factors , such as PDGF A and TGF beta 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Following MK 801 treatment , the presence of c FOS , FOS B , KROX 24 , c JUN , JUN B , and JUN D were investigated by immunocytochemistry with specific antisera at different time intervals up to 48 h . ^^^ More complex effects were observed in the neocortex : MK 801 did not influence constitutive expression of different FOS and JUN proteins , but caused marked induction of c FOS , FOS B , JUN B and JUN D , mainly in layer 4 , but also in layers 5 and 6 . ^^^ Subcortical areas such as the hypothalamus and thalamus demonstrated an induction of a subset of immediate early genes ( c fos , fos B , Krox 24 , jun B ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The glucocorticoid receptor complex binds to a protein complex AP 1 ; consisting of the proteins c JUN and c FOS ) and prevents this complex from inducing activation of the procollagenase gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , exposure of T lymphoblastoid cells to a 60 Hz sinusoidal magnetic field altered the transcription of genes encoding c fos , c jun , c myc , and protein kinase C . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Seizures elicited by chemoconvulsants induced expression of mRNA for c fos , c jun , and junB and Fos like immunoreactivity in lung tissue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Serum induces the expression of a number of proteins with similar transcriptional properties , including those encoded by the proto oncogenes c fos and c jun . ^^^ Thus , the antisense rescue method defines a specialized function for c Fos protein which is distinct from the function ( s ) of Jun and / or transforming FBR 5 Fos proteins . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun family genes after focal cerebral ischemia . ^^^ The expression of the protooncogenes , c fos , jun B , c jun , and jun D was investigated in a rat focal cerebral ischemia model by Northern analysis and in situ hybridization . ^^^ Nuclear run on assays indicated that the increase in c fos , jun B , and c jun mRNA levels was due to the increase of transcription rate in these genes . ^^^ Ischemia for 30 minutes , which caused only slight cortical damage ( infarct size , < 10 mm 3 ) , induced both jun B and c fos mRNAs exclusively in the right cerebral cortex . ^^^ The coinduction of jun B and c fos expression occurred immediately after reperfusion and peaked at 60 minutes after reperfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We now examine the impact of 1 , 25 ( OH ) 2D3 on the induction by alpha thrombin of c jun and c fos mRNA . ^^^ However , when cells were exposed to 1 , 25 ( OH ) 2D3 for 48h prior to thrombin , c jun expression after alpha thrombin was reduced to less than 25 % of the level in cells exposed to thrombin alone . c fos expression after alpha thrombin was unaffected by 1 , 25 ( OH ) 2D3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Introduction of the mouse gamma chain cDNA clone into a mouse fibroblast cell line , L 929 , expressing the mouse alpha beta heterodimer IL 2 receptor converted pseudo high affinity of the IL 2 receptor into functional high , resulting in internalization of IL 2 and induction of the c myc , c fos and c jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of the grp genes by both reagents requires several hours of sustained treatment , in contrast to the rapid induction previously described for c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of overexpression of individual components of the AP 1 transcription complex ( ie , c fos and c jun ) were examined in neonatal rat atriocyte cultures . ^^^ This inhibitory activity was localized to the carboxy terminus of the c fos protein and dominated the more conventional AP 1 dependent activity located elsewhere in the c fos molecule . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis was used to study the effects of acrylamide , a potent neurotoxin , on the induction of c fos and c jun mRNA in rat brain . ^^^ Acute administration of acrylamide caused a statistically significant increase in the expression of c fos ( approx . 37 % ) and c jun ( approx . 17 % ) mRNA in rat brain . ^^^ By contrast , the level of c fos mRNA in chronic acrylamide treatment was not altered significantly , but the expression of c jun mRNA was increased almost 100 % as compared to control . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reactivation of a membrane associated tyrosine kinase ( tsRCAN 29 ) results in a several fold increase in AP 1 DNA binding and a similar increase in the activity of an AP 1 responsive reporter soon after temperature shift . c Jun and c Fos are regulated at a number of levels in response to both stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differences in the steady state levels of c fos , c jun and c myc messenger RNA during mitogen induced liver growth and compensatory regeneration . ^^^ The steady state levels of c fos , c jun and c myc messenger RNA were investigated in rat liver tissue after proliferative stimuli of different nature namely , compensatory regeneration induced by partial hepatectomy or carbon tetrachloride administration and direct hyperplasia induced by four different hepatomitogens : lead nitrate , ethylene dibromide , cyproterone acetate and nafenopin . ^^^ We show here that whereas c fos and c jun expression increased soon after partial hepatectomy or carbon tetrachloride administration , an increased expression of c jun in the absence of c fos expression occurred during direct hyperplasia induced by lead nitrate and ethylene dibromide . ^^^ When hyperplasia was induced by cyproterone acetate and nafenopin , the mitogenic response of the liver was not associated with an increased expression of c jun or c fos , despite the fact that the timing of the cell cycle was similar to that observed after partial hepatectomy . ^^^ On the contrary , the hyperplasia induced by cyproterone acetate and nafenopin , which is characterized by a lack of increase in the expression of c fos and c jun , was also not associated with an increased c myc expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Goldfish and rat optic nerves were cut and crushed , respectively , and the expression of the transcription factor proteins c JUN , JUN B , JUN D , c FOS , FOS B , KROX 24 , and CREB was investigated in retinal ganglion cells ( RGCs ) by immunocytochemistry . ^^^ Expression of JUN B , c FOS , FOS B could not be detected in rat RGCs after optic nerve crush . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neuronal excitation elicits rapid transcriptional activation of several immediate early genes , for example c fos , c jun and zif 268 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transgenic mice overexpressing the c fos proto oncogene in bone develop osteosarcomas , whereas mice overexpressing c Jun are normal . ^^^ Cell lines isolated from Fos Jun transgenic tumors expressed high levels of both transgenes but significantly lower levels of the jun related gene junB compared with cells expressing only a c fos transgene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Deregulated c Fos / AP 1 accelerates cell cycle progression of B lymphocytes stimulated with lipopolysaccharide . ^^^ We implicated deregulated c Fos / AP 1 in proliferative response of B lymphocytes stimulated with lipopolysaccharide ( LPS ) using splenic B cells from c fos transgenic ( Mx c fos ) mice . ^^^ Levels of DNA synthesis of the Mx c fos B cells were augmented in proportion to the amount of AP 1 . ^^^ Since the number of LPS responding splenic B cells from Mx c fos mice was similar to that from control mice duplication time of the Mx c fos B cells ( 0 . 9 days ) was much shorter than that of the control B cells ( 2 . 1 days ) , this augmentation is explained by the acceleration of cell cycle progression by deregulated c Fos / AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of AP 1 activity using gel mobility shift assays confirms that the requirements for synergy in c fos mRNA induction are paralleled by requirements for synergy in induction of AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This model is associated with intense stimulation of the ascending pathway to the cerebral cortex , seizure activity , and subsequent ipsilateral cortical induction of various immediate early genes ( IEGs ) , including c fos , c jun , and zif 268 , and ornithine decarboxylase enzyme activity and mRNA , all of which processes are sensitive to treatment with the N methyl D aspartate ( NMDA ) receptor antagonist MK 801 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that both conjugation and degradation are significantly stimulated by c Jun , with which c Fos forms the active heterodimeric transcriptional activator AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , p 202 binds the NF kappa B p 50 and p 65 and the AP 1 c Fos and c Jun transcription factors in vitro and in vivo . ^^^ The interferon inducible p 202 protein as a modulator of transcription : inhibition of NF kappa B , c Fos , and c Jun activities . ^^^ NF kappa B , c Fos , and c Jun participate in the transcription of various cellular and viral genes , and thus p 202 can modulate the expression of these genes in response to interferons . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of immediate early genes ( IEG ) s c fos , c jun and zif / 268 was studied during naloxone precipitated morphine withdrawal in various organs of the rat . ^^^ Increased levels of c fos and c jun mRNA were observed in the spinal cord at 40 min of morphine withdrawal . ^^^ An increase in c fos and c jun but not zif / 268 mRNAs was seen in the jejunum between 20 and 60 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Uteri from tamoxifen treated , castrated rats were examined histologically , and cell type specific expression of c fos , c jun , jun B , and jun D was assessed using in situ hybridization . ^^^ In this study , we determined which of the several uterine tissues ( myometrium , stroma , and luminal and glandular epithelium ) demonstrated chronic overexpression of c fos and the jun proto oncogenes in response to tamoxifen . ^^^ Expression of c fos and jun B messenger RNA was first detected in the luminal and glandular epithelial at 12 36 h post tamoxifen injection . ^^^ Seven days after tamoxifen treatment , c fos and jun B messenger RNA levels were lower but still evident in the uterine endometrial epithelium . ^^^ These results support our working hypothesis that persistent overexpression of cellular oncogenes c fos and jun B in the uterine endometrial epithelium may contribute to the molecular mechanism underlying the uterine toxicity associated with chronic tamoxifen treatment . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This proliferative defect is associated with the markedly reduced induction of c jun , c fos , Fra 2 and FosB following activation of the CREBA 119 transgenic thymocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using in situ hybridization , the expression of c fos , fosB , fra 1 , fra 2 , c jun and junB was studied after 15 min of normothermic and hypothermic ( 33 degrees C ) transient forebrain ischaemia in the rat , induced by common carotid occlusion combined with systemic hypotension . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The purpose of these studies was ( 1 ) to determine whether c fos is expressed as part of a typical immediate early ( IE ) gene response , which would require co expression of c jun and sensitivity to cycloheximide , and ( 2 ) to determine whether the cells expressing c Fos are the same as those undergoing DNA synthesis . ^^^ Northern analysis was performed on renal mRNA at different times following release of a 50 minute period of renal hilar clamping . c jun and c fos mRNA were rapidly and briefly expressed following renal ischemia and their expression was superinduced by cycloheximide in a manner typical of an immediate early gene response . 3H thymidine autoradiography performed on semi thin sections from intravascularly perfusion fixed kidneys 24 hours following induction of ischemia showed labeled nuclei in cells lining the damaged proximal tubules of the outer stripe of the outer medulla , as well as proximal tubules in the cortex and interstitial cells throughout the kidney . ^^^ However , immunohistochemical localization of c Fos and c Jun protein occurred predominantly in nuclei of the thick ascending limb , distal tubule and collecting duct cells . ^^^ The studies demonstrate that c fos and c jun are expressed following renal ischemia as a typical immediate early gene response , but they are expressed in cells that do not enter the cell cycle . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Insulin regulates expression of c fos and c jun and suppresses apoptosis of lens epithelial cells . ^^^ To explore the mechanism of the action of insulin as a survival factor for 6 day embryonic lens explants , we compared the pattern of cell cycle markers ( c fos , c jun , c myc , p 53 , histone H 3 , thymidine kinase , and cyclin B ) in both apoptotic and differentiating lens explants . ^^^ In the presence of insulin , the expression of c fos and c jun was down regulated after an initial induction . ^^^ Since c fos and c jun have been shown to play a role in apoptosis in other cell types , the ability of insulin to regulate expression of these genes may be central to its ability to act as a survival factor for lens epithelial cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Prolactin ( PRL ) injected subcutaneously increased hepatic ODC activity as well as mRNA levels of ODC and the proto oncogenes c fos , c jun , junB , junD , c myc , and max . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Also , dFdC was able to increase the expression of both c jun and c fos in Molt 3 leukemic cells with a concentration known to induce apoptosis in this cell line . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of expression of JTAP 1 in CEF overexpressing other oncogenes including 5 Ha ras , 5 Src , c Fos , and Myc revealed that it ' s overexpression is unique to 5 Jun transformed cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One contains a binding site that selectively binds c Fos and c Jun in vitro and confers a response to multiple AP 1 family members in vivo . ^^^ Furthermore , a complex of c Jun and c Fos interacted with c Ets 1 in vitro . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : 1 ) Bladder DNA synthesis was elevated 4 fold at 24 hours after ischemia ; 2 ) protein synthesis was increased 2 fold at 8 and 24 hours after ischemia ; 3 ) early response genes ( c fos and c jun ) mRNAs were induced by 1 hour of ischemia ; hsp 70 mRNA was highly induced by 8 hours of ischemia , and bFGF mRNA was elevated 3 to 5 fold by 8 hours of ischemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several recent studies , using both expression and functional assays , have implicated the transcription factor , AP 1 , in the regulation of programmed cell death , and specifically implicate the genes c fos and c jun , as well as some other family members . ^^^ Programmed cell death in the absence of c Fos and c Jun . ^^^ If the products of the c fos and / or c jun genes are essential components in the cascade of events that leads to programmed cell death in mammalian cells , it follows that cell death would not occur in mice lacking functional copies of these genes . ^^^ We have made use of null mutations in the c fos and c jun genes that were produced by gene targeting ( Johnson , R . ^^^ Cell death was assayed using an in situ apoptosis assay in c fos null embryos and adults , c jun null embryos , and c fos / c jun double null embryos compared with control mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Kinase activation is followed by an increase in c fos and c jun gene expression and enhanced activating protein 1 ( AP 1 ) DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the immediate early genes c fos , c jun and c myc in rat stomach in response to feeding and gastric distension was examined by Northern blot analysis and in situ hybridization . 2 . ^^^ In conscious rats prepared with a gastric fistula , gastric distension with nutritive and non nutritive solutions at a physiological pressure for 30 min induced expression of c fos , c jun and c myc , but not GAPDH . 4 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Glutathione s transferase B ATF heterodimerizes efficiently with in vitro translated JunB , c Jun , and JunD , but only weakly associates with c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated if PTH regulated mRNA expression of proto oncogenes , c fos , c jun , and c myc , early response genes that have been shown to be involved in the regulation of both cell proliferation and differentiation . ^^^ Subcutaneous administration of a single injection of human PTH ( 1 34 ) at 8 micrograms / 100 g , a dose known to increase bone forming surfaces , induced rapid and transient expression of c fos , c jun , c myc , and IL 6 mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In B CLL and HCL cells , the generation of nuclear localized c jun and c fos proteins ( components of AP 1 ) in response to TNF or PMA appears to be blocked . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using the techniques of immunohistochemistry , Northern blotting and in situ hybridization , we have found that electroacupuncture ( 2 / 15Hz ) accelerated the expression of mRNA and protein synthesis of immediate early genes c fos , c jun as well as proenkephalin gene in rat central nervous system ( CNS ) . ^^^ Morphological study demonstrated that the sites of c fos , c jun and PENK mRNA expression and protein synthesis coincide with each other in the CNS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neither ERK nor JNK / SAPK MAP kinase subtypes are essential for histone H3 / HMG 14 phosphorylation or c fos and c jun induction . ^^^ The effects of EGF , TPA , UV radiation , okadaic acid and anisomycin on ERK and JNK / SAPK MAP kinase cascades have been compared with their ability to elicit histone H3 / HMG 14 phosphorylation and induce c fos and c jun in C3H 10T1 / 2 cells . ^^^ Nevertheless , all these agents elicit phosphorylation of ribosomal and pre ribosomal S 6 , histone H 3 and HMG 14 , and the induction of c fos and c jun , showing that neither cascade is absolutely essential for these responses . ^^^ We then analysed the relationship between ERKs , JNK / SAPKs and the transcription factors Elk 1 and c Jun , implicated in controlling c fos and c jun , respectively . ^^^ Thus , neither ERKs nor JNK / SAPKs are absolutely essential for nuclear signalling and c fos and c jun induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Rat neonatal cardiac myocytes were exposed to H2O2 , and changes in c fos and c jun mRNAs , immunoreactive c Fos and c Jun proteins ( components of AP 1 ) , and immunoreactive p 50 subunit of NF kappa B were determined . ^^^ The levels of c Fos and c Jun proteins increased in nuclei as revealed by immunostaining , and DNA binding activity of nuclear AP 1 increased . ^^^ When myocytes were exposed to nonlethal concentrations of H2O2 , c fos and c jun mRNAs were rapidly induced , reaching peak values at 30 60 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , deletion of this major exonic AP 1 site from the POMC constructs greatly reduced the effect of c fos overexpression but did not suppress POMC stimulation by CRH , indicating that CRH stimulates POMC transcription by one or more cFos independent mechanism ( s ) . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Experiments were performed on pheochromocytoma 12 ( PC 12 ) , hepatoblastoma ( Hep3B ) , neuroblastoma and fibroblast cells that were exposed either to normoxia ( 21 % O 2 ) or to hypoxia ( 5 % O 2 ) for one hour . mRNAs for c fos , c jun , junB , junD were analyzed by northern blot assay . ^^^ Cell selective induction and transcriptional activation of immediate early genes by hypoxia . c fos and jun belong to the immediate early response genes ( IERG ) that initiate phenotypic changes in response to a variety of extracellular stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This irreversibly changed vaginal epithelium persistently expressed higher levels of c jun and c fos mRNAs , which was not altered by postpubertal estrogen . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The complex bound to the TH AP 1 site contained c fos and other proteins ( including cJun ) . ^^^ Immunoblots found that c fos is induced in the adrenal medulla near maximally by one hour immobilization and cJun and JunD are present in higher constitutive levels and are only moderately regulated by immobilization stress . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with these data , CD 40 signals up regulate c jun but not c fos mRNA and alter the transcription factor ATF 2 but not the Raf 1 protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of AP 1 ( c Fos and c Jun proteins ) and NF kappa B transcription factors were also inhibited . ^^^ IL 2 , IL 2 receptor alpha chain , IFN gamma , c fos , c jun , and c myc mRNAs were not detected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , analysis of the effect of AP 1 proteins on the collagenase and TIMP 1 promoters in gastric carcinoma KKLS cells revealed that c Fos combined with any of the Jun related proteins failed to stimulate the TIMP 1 promoter , though collagenase promoter was effectively activated by any Fos / Jun related protein heterocomplex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These effects were not accompanied by alterations in endothelin induced c fos , c jun , or c myc gene expression , suggesting either that the inhibitory locus responsible for the reduction in the mRNA levels lies distal to the activation of the immediate early gene response or that the two are not mechanistically coupled . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As with the expression of c fos , supersensitive DI receptors may play a key role in the enhanced induction of AP 1 and CREB DNA binding activity in the dopamine depleted striatum . ^^^ Supershift analysis revealed that c Fos ; and Jun family proteins are the main components for AP 1 induced in the dopamine depleted striaturn by SKF 38393 or levodopa . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the other hand , it could represent an in vivo confirmation of previously reported in vitro paf effects inducing c fos and c jun expression , two members of the so called ' cellular immediate early gene ' family . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The current studies were designed to characterize the involvement of immediate early response genes , c fos and c jun , in interleukin 1 ( IL 1 ) induced expression of iNOS . iNOS messenger RNA ( mRNA ) expression by both rat islets and RINm5F cells was time dependent , with maximal expression observed after an approximately 3 to 6 h exposure to IL 1 . ^^^ IL 1 also stimulated rapid and transient expression of c fos and c jun by both rat islets and RINm5F cells , with maximal mRNA accumulation detected 30 60 min after IL 1 treatment . ^^^ The present study , however , indicates that IL 1 induced expression of Fos and Jun does not seem to participate in the regulation of iNOS and mRNA expression , because : 1 ) cycloheximide ( 1 microM ) completely inhibited Fos expression but had no inhibitory effect on iNOS mRNA levels ; and 2 ) tyrosine kinase inhibitors genistein and herbimycin A completely inhibited IL 1 induced iNOS expression but did not block c fos and c jun expression . ^^^ These results indicate that two separate signaling pathways may exist for induction of c fos and c jun and iNOS genes and that de novo synthesis of Fos and Jun does not participate in the regulation of iNOS gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Temporal changes in insulin like growth factor 1 , c fos , and c jun gene expression during hyperplastic kidney growth in weanling rats . ^^^ The mRNAs for the early response genes , c fos and c jun , were not induced in the remnant kidneys from weanling rats until between 12 18 h , but were also sustained through 48 h post UNX . ^^^ These findings suggest that early CRG in the weanling rat is associated with rapid increases in IGF 1 mRNA followed by a rise in c fos and c jun gene expression and a mitogenic response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These data suggest that oestrogen may increase transcription of the Cx 43 gene through direct mechanisms ( via the putative oestrogen response elements ) or indirect mechanisms ( by increased expression of c fos and c jun acting via the putative AP 1 sites ) . ^^^ In addition , treatment of rats with oestrogen significantly increased mRNA encoding c fos and c jun in the myometrium and this occurred before any increase in Cx 43 mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These substrates include transcription factors that are regulated by MAP kinase phosphorylation ( e . g . , Elk 1 , c Myc , c Jun , c Fos , and C / EBP beta ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since FOS and JUN proteins form a transacting activator ( AP 1 ) for expression of collagenase and stromelysin genes , PC may block the synthesis of both enzymes by inhibiting the transcription of c fos and c jun . . ^^^ Moreover , PC ( 10 ( 3 ) M ) also blocked the crystal induction of c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogene product c Fos , a component of the transcription factor AP 1 , plays a critical role in the expression of genes required for cellular proliferation and differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After this depletion , EGF transiently increased fos and jun mRNAs : the expression peaked at 45 minutes for c fos ( 5 . 5 fold induction ) and at 60 minutes for c jun and jun B ( 3 fold induction ) and the mRNA levels returned to the basal value within 3 hours . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using a glutathione S transferase ( GST ) fusion protein system , we show that E 7 complexes with AP 1 transcription factors including c Jun , JunB , JunD and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ubiquitinylation of transcription factors c Jun and c Fos using reconstituted ubiquitinylating enzymes . ^^^ Recombinant c Jun and c Fos were ubiquitinylated by the ubiquitin carrier enzymes E214K , E220K , or E232K in the presence of the ubiquitin activating enzyme , E 1 . ^^^ Addition of ubiquitin protein ligase E 3 substantially enhanced the E214K mediated ubiquitinylation of c Jun and c Fos . ^^^ Truncated c Jun and c Fos mutant proteins including wbJun and wbFos were also ubiquitinylated under the same conditions , suggesting the sites of ubiquitinylation are located within the dimerization and DNA binding domains of c Jun and c Fos . ^^^ The E 3 dependent ubiquitinylation of c Jun was inhibited upon the heterodimerization of c Jun with c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , evidence is presented that EPO induces the expression of early response genes c jun , junD and c fos mRNA , stimulates jun protein synthesis and induces activation of 5 10 AP 1 / CAT activity in hyman erythroleukemia K 562 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study shows that induction of heme oxygenase 1 ( HO 1 ) gene expression by a glutathione ( GSH ) depletor , phorone , is inhibited by cycloheximide pretreatment and involves changes in c jun , not c fos , mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The interferon inducible growth inhibitory p 202 protein : DNA binding properties and identification of a DNA binding domain . p 202 is an interferon inducible protein whose expression in transfected cells inhibits proliferation . p 202 binds to the retinoblastoma tumor suppressor protein in vitro and in vivo and the transcription factors AP 1 c Fos and c Jun , NF kappaB p 50 and p 65 , and inhibits the transcriptional activity of these factors in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This was accompanied by an early peak of c jun and c fos synthesis ( 3 hours after addition of h rHGF ) followed by c myc ( 6 hours ) and increased expression of cyclins A , B , D , and E ( 12 hours after h rHGF ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both TrkC and TrkA mediate qualitatively similar increases in the tyrosine phosphorylation of phospholipase C ( PLC ) gamma 1 , Shc , SNT , and MAPK and the transcription of the c fos , c jun , NGFI A , and NGFI B immediate early genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c Jun and Fra 1 was increased more than threefold in H ras transfectants compared with Balb Neo 1 , 5 myc and H ras / v myc transfectants , but that of c Fos , Jun B and SP 1 was unchanged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of neonatal rat cardiac myocytes to ouabain concentrations that caused partial inhibition of Na+ / K+ ATPase but no loss of viability , increased c fos and c jun mRNAs and the transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that the G0 / G1 transition occurs during hepatocyte isolation as evidenced by the expression of early genes such as c fos , c jun , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ZEBRA and cellular AP 1 bZip activators , such as c Fos , have homologous DNA binding domains , and their DNA binding specificities overlap . ^^^ Chimeric ZEBRA / c Fos proteins overexpressed in Escherichia coli bound DNA with the specificity of c Fos ; they bound a heptamer AP 1 site and an octamer TPA response element ( TRE ) . ^^^ Both ZEBRA and the ZEBRA / c Fos chimeras activated transcription from reporters with multimerized AP 1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibodies against CRE binding ( CREB ) protein but not against c Fos or c Jun were able to supershift the DNA protein complex , identifying the nature of the transcription factor which binds to ZII as a member of the CREB family of proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Disruption of the c fos proto oncogene , a major component of the AP 1 transcription factor complex , leads to an osteopetrotic phenotype characterized by a complete absence of osteoclasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased c fos mRNA and binding to the AP 1 recognition sequence accompanies the proliferative response to deoxycholate of HT 29 cells . ^^^ We demonstrate that deoxycholate caused an increase in expression of c fos mRNA and increased binding to the AP 1 site , effects which were maximum at the concentration at which the bile acid induced the maximum proliferative effect on the cells . ^^^ In addition , we show that the AP 1 complex induced by treatment of the cells with the bile acid contained the c fos protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibody supershift experiments clearly revealed that the majority of protein components in induced AP 1 DNA binding activity were the products of oncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TCDD did not increase mRNA of c fos , c jun , junB or junD ( in contrast to TPA which markedly increased the expression of c fos and junB ) , nor did TCDD increase AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The treatments induced a transient increase in c fos and c jun mRNA levels , with maximum values at 1 6 hr ; a transient increase in collagenase mRNA level , with a maximum value at 48 hr ; and a progressive increase in vimentin and lamin A and C mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The reduced ERK 2 activity in response to EGF was associated with decreased c fos and c jun mRNA expression and lower levels of AP 1 transcription factor DNA binding activity in the aged hepatocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In bovine chromaffin cells forskolin , phorbol ester , or high potassium levels induce a rapid increase of c fos , c jun , and junB mRNA levels , which precede an induction of proenkephalin gene expression . ^^^ Moreover , cotransfection of c fos , but not of c jun or CREB , expression plasmids transactivated the expression of the PENKCAT reporter genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Application of AP 1 partner mRNAs shows an increase in levels of c fos and c jun mRNAs after BDNF treatment , resulting from an induction of their promoters . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report that treatment of resting ( serum deprived ) NIH 3T3 cells with cyclocheximide ( CH ) or puromycin induces expression of c fos , c jun and c myc proto oncogenes in a manner similar to that of platelet derived growth factor ( PDGF ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Growth inhibition was distal to early growth signaling events because induction of c fos , c jun , and egr 1 mRNA was unaffected by atRA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine whether differences in AP 1 activity could account for these observations , the induction of c fos and c jun mRNAs was studied in conjunction with gel shift assays for AP 1 binding . ^^^ These data suggest there may exist an AP 1 independent route to message induction or that factors other than c FOS and c JUN may be used in certain circumstances . ^^^ Antisense oligonucleotides to c fos and c jun strongly inhibited the induction of stromelysin mRNA in primary cells treated with PMA , but was only weakly active against message induction in HIG 82 cells . ^^^ Western blot analyses detected no marked difference between HIG 82 cells and primary cells in their resting levels of c FOS and c JUN . ^^^ Thus the differences reported here between HIG 82 cells and primary cells in their resting levels of c FOS and c JUN . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Irreversible terminal differentiation induced by VD 3 is associated with down regulation of the expression of c myc and upregulation of the expression of c fos and c jun , but ML 9 did not affect the expression of these oncogenes appreciably . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In both insulin sensitive and insulin resistant persons , RNA quantities of GLUT 4 , c jun , c fos , and the insulin receptor did not change over the period of insulin infusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antisense oligodeoxyribonucleotides ( oligos ) directed against c fos , c jun , or the cAMP response element binding protein ( CREB ) mRNA were injected into both PVN before insulin induced hypoglycemia to assess whether activator protein 1 or CREB mediates transcriptional activation of CRF during hypoglycemia . ^^^ During insulin induced hypoglycemia , which stimulates CRF gene expression and release , c fos and c jun mRNA increases in the hypothalamic tissue preceded the increase in the CRF mRNA level after insulin induced hypoglycemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Priming of human monocytes with IFN gamma resulted in the down regulation of c fos and c jun mRNA in response to stimulation with lipopolysaccharide ( LPS ) compared to the effects of LPS alone . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun proteins and AP 1 binding activity during cell cycle progression of HL 60 cells and phytohemagglutinin stimulated lymphocytes . ^^^ The protein products of the c fos ( p62c fos ) and c jun ( p39c jun ) genes are members of the AP 1 transcription factor family and are thought to play important roles in the regulation of gene expression during the cell cycle . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription from several promoters , including the oncogene responsive element in the polyomavirus enhancer , the c fos promoter , as well as other AP 1 and Ets dependent promoters , can be induced by Raf 1 kinase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Complement activation and TCC assembly induced expression of c jun , JunD , and c fos mRNAs , increased AP 1 DNA binding activity within 1 h , and increased [ 3H ] thymidine uptake . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the immediate early genes ( IEG ) s c fos , c jun and zif / 268 , and the genes coding for ornithine decarboxylase ( ODC ) and its regulatory protein antizyme ( AZ ) , was studied in rat small intestine following transient ischemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that c fos and c jun mediate their effects through both AP 1 1 and AP 1 2 which function in an additive manner . ^^^ Co transfection of c fos and c jun expression constructs with a CD11c promoter CAT fusion into HL 60 cells led to a 6 . 7 fold increase in CD11c promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased HO 1 gene transcription was associated with increased activator protein 1 ( AP 1 ) binding activity and supershift of the AP 1 complex by antibodies to c Fos and c Jun after hyperoxia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun in rat retina following protracted illumination . ^^^ Neuronal expression of the immediate early genes ( IEGs ) c fos and c jun , both recognized as proto oncogenes , has been reported after stimulation of different regions in the central nervous system ( CNS ) . ^^^ Increases in c fos and c jun products during the darkness period may play a role in triggering molecular events participating in plastic changes in photoreceptors and / or in the protection for oxidative damage cause by free radicals induced by light irradiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A systematic study was undertaken to assess the expression of nuclear proto oncogenes , c myc , c fos , and c jun , and suppressor genes , p 53 and WT 1 , by Northern blot analysis to further support this scheme . ^^^ Moreover , the expression of 2 . 2 kb c fos transcript rose 4 . 6 and 4 . 8 fold ; and 3 . 2 and 2 . 7 kb c jun expression increased 2 . 8 and 5 . 1 fold at these same respective estrogen treatment time intervals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Brief visual stimulation ( 2 hr ) added c Fos , c Jun , and JunB to this complex , whereas prolonged stimulation ( 6 24 hr ) reduced c Fos and c Jun levels significantly , leaving only FosB , JunB , and JunD as the major components of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Domain swaps made between the c jun non AUUUA and the c fos AUUUA containing AREs reveal that the two AREs , while sharing no sequence homology , appear to contain sequence domains that are structurally distinct but functionally overlapping and exchangeable . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , phosphorylation of the 66 kDa She protein , activation of mitogen activated protein kinase , and induction of c fos and c jun occur either to a lesser extent or for a shorter time in ER 1 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive expression of c fos and c jun , overexpression of ets 2 , and reduced expression of metastasis suppressor gene nm 23 H1 in rheumatoid arthritis . ^^^ RESULTS : Our data confirm the role of c fos and c jun as constitutive signal transmitters in solid RA tissues , thus demonstrating the potential of the approach . ^^^ The constitutive expression of c fos and c jun in RA tissue most probably results from a continuing inflammatory stimulus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PACAP stimulates transcription of c Fos and c Jun and activates the AP 1 transcription factor in rat pancreatic carcinoma cells . ^^^ In parallel to c fos / c jun induction , PACAP rapidly activates the heterodimeric transcription factor AP 1 , as shown by electrophoretic mobility shift assay . ^^^ These findings demonstrate that signal transduction of a growth stimulating G protein coupled receptor involves the c fos / c jun / AP 1 cascade , a pathway mainly linked to classical growth factor receptor tyrosine kinases . . ^^^ RT PCR analysis revealed that this mitogenic effect of PACAP is preceded by a rapid and transient increase of transcription of the protooncogene c fos and to a lesser extent of c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Subsequent to CREB phosphorylation , the expression of the CRE containing gene , c fos , and the AP 1 complexes ( heterodimers of Fos and Jun family members ) is increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Other downstream targets for ceramide action include Cox , IL 6 and IL 2 gene expression , PKC zeta , Vav , Rb , c Myc , c Fos , c Jun and other transcriptional regulators . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has provided insights into the concerted action of extracellular ( HGF / SF , TGF alpha , EGF , TGF beta ) and intracellular factors ( c myc , c fos , c jun , p 53 , c met , and others ) in liver regeneration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nine of these genes ( H ras , c myc , c fos , c jun , junB , N myc , c abl , c yes , and p 53 ) were expressed in epithelial cells , whereas two ( RB 1 and N ras ) were not . expression of four other genes ( c src , K ras , c raf , and c myb ) was observed , but the intensity of these bands was too low for densitometric analysis . ^^^ The steady state levels of transcripts of H ras and five nuclear protooncogenes ( c myc , c fos , c jun , junB , and N myc ) were lower in epithelial cells from involved or uninvolved IBD samples than in normal epithelial cells from either sporadic colon cancer or diverticulitis patients . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun during hepatocellular remodeling following ischemia / reperfusion in mouse liver . ^^^ In this study , we sought to evaluate the potential involvement of c jun and c fos as determinants either of cellular regeneration or programmed cell death following ischemia / reperfusion ( I / R ) in mouse liver . ^^^ To this end , we have analyzed the in situ messenger RNA ( mRNA ) expression patterns of c jun and c fos following lobar I / R in mouse liver . ^^^ The expression patterns of c jun and c fos were correlated with four criteria for tissue repair and injury , including : 1 ) morphological determinations of regeneration using immunocytochemical detection of proliferating cell nuclear antigen ( PCNA ) , 2 ) programmed cell death ( apoptosis ) using the in situ terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling ( TUNEL ) method , 3 ) histopathologic assessment of hepatocellular necrosis , and 4 ) serum glutamic pyruvic transaminase ( GPT ) levels . ^^^ Two distinct patterns of c jun and c fos expression were observed during the acute ( 1 3 hours ) and subacute ( 6 20 hours ) phases of liver responses to I / R including : 1 ) coexpression of c jun and c fos mRNA within damaged regions of the liver at 1 to 3 hours ' postreperfusion , and 2 ) a decline in c fos expression with sustained high levels of c jun expression within a subset of cells bordering necrotic / apoptotic regions of the liver at 6 to 20 hours ' postreperfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
New protein synthesis ( incorporation of [ 3H ] phenylalanine [ Phe ] ) was analyzed in isolated perfused rat hearts after a 3 h protocol ; c fos , c jun , c myc , and early growth response gene 1 ( EGR 1 ) mRNA levels ( Northern blot ) were studied over a time course from 15 to 240 min of perfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Asbestos causes protracted , dose dependent increases in steady state mRNA levels of the proto oncogenes c fos and c jun , and AP 1 DNA binding activity in normal rat pleural mesothelial ( RPM ) cells ( 1 ) . ^^^ Our results are unique in that they demonstrate that asbestos induces apoptosis in mesothelial cells at concentrations eliciting increased expression of the proto oncogenes c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the first steps of gene activation , this study focused on the proto oncogenes c jun and c fos , both coding for the transcription factor activator protein 1 ( AP 1 ) , which was found to mediate IL 6 gene expression . ^^^ Expression of the c jun and c fos genes was determined by way of Northern blot analysis , and DNA binding activity of the transcription factor AP 1 was evaluated by electrophoretic mobility shift assay ( EMSA ) . ^^^ Strong and prolonged induction of c jun and c fos proto oncogenes by photodynamic therapy . ^^^ Compared with the transient expression of c jun and c fos by phorbol ester stimulation , photodynamic treatment led to a prolonged activation pattern of both immediate early genes . ^^^ Furthermore , mRNA stability studies revealed an increased half life of c jun and c fos transcripts resulting from photosensitisation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report the expression of the immediate early gene c fos and c jun mRNAs and of HSP 72 mRNA and protein in several models of cerebral HI . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The current study examined the effects of oxidative stress on transcriptional activities mediated by c Fos / c Jun AP 1 and the nuclear factor of activated T cells ( NF AT ) . ^^^ The present results show that Jurkat T cells acutely exposed to micromolar concentrations of H2O2 exhibit substantial increases in AP 1 binding activity and the expression of c jun but not c fos mRNA . ^^^ Similarly , the complexes binding the consensus AP 1 TRE and jun TRE like motifs in cells exposed to oxidative signals or PHA / PMA were indistinguishable , being composed of c Fos , c Jun , and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hypertonic stress induces c fos but not c jun expression in the human embryonal EUE epithelial cell line . ^^^ Recent evidence has indicated a role for the two early response genes c fos and c jun in transcriptional regulation of genes acting in osmoregulation . ^^^ The treatment of EUE cells with cycloheximide led to superinduction of c fos expression , ( with high levels up to 12 h ) , and to a c jun expression that was just detectable . ^^^ Hypertonic stimulation of the transformed cell lines A 549 , MCF 7 and JR induced both c fos and c jun only in JR cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We showed a time dependent variation of c jun mRNA expression with an early and transient dose dependent induction followed by a second increase at 24 and 48 h : a biphasic dose dependent variation of bcl 2 expression 30 min after irradiation with a reduction of mRNA level at 1 Gy , and a normalization at higher doses and stable levels of mRNA for c fos , c myc , G CSF , GM CSF , IL 6 , TNF alpha , TGF beta , and MIP 1 alpha genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PAF induced transcription of protooncogenes c fos and c jun as well as of interleukin ( IL ) 6 and IL 8 genes in human fibroblasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Pressure overload hypertrophy is mediated by both the renin angiotensin system and the response of cardiomyocytes to stretch ; both lead to activation of early oncogenes ( c fos , c jun , c myc ) and angiotensin 2 activates several protein kinases involved in cell growth . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C jun , c fos and c myc oncoproteins seem to be largely restricted to the synovial cells attached to the sites of cartilage and bone destruction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot and gel mobility shift assays showed that hypoglycemic treatment induced c jun and c fos gene expression , AP 1 binding activity , as well as bFGF gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Calcium induced AP 1 DNA binding complexes consist of Fra 1 , Fra 2 , c Jun , JunB and JunD and are independent of c Fos , since the induction of DNA binding activity and the composition of the AP 1 binding complexes are identical in differentiating keratinocytes derived from c fos null and wild type mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Estrogen induces expression of c fos and c jun via activation of protein kinase C in an endometrial cancer cell line and fibroblasts derived from human uterine endometrium . ^^^ Endometrial fibroblasts derived from uterine endometrium as controls and endometrial cancer cell lines ( Ishikawa and HHUA cells ) were analyzed for the induction manner of c fos and c jun transcripts in endometrial cancers , some of which are estrogen dependent in growth . ^^^ Progesterone diminished c fos and c jun expression and PKC activity induced by estradiol in the fibroblasts , but not in Ishikawa cells , which persistently overexpressed c fos and c jun . ^^^ In these cells , 12 0 tetra decanoylphorbol 13 acetate ( TPA ) increased c fos and c jun expression as did estradiol . ^^^ Pretreatment with 1 ( 5 isoquinolinesulfonyl ) 2 methylpiperazine dihydrochloride ( H 7 ) abolished estrogen inducible over expression of c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast to ERKs and c Fos , thrombin induced JNK 1 activation and c Jun expression were sensitive to inhibition by forskolin , suggesting an association of these events with thrombin stimulated growth in these cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Development of a sensitive peptide based immunoassay : application to detection of the Jun and Fos oncoproteins . c Jun and c Fos belong to the bZIP class of transcriptional activator proteins , many of which have been implicated in the neoplastic transformation of cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Experiments with antisera to the AP 1 family of transcription factors indicated that c fos and JunB bind to the IL 5 CLE 0 in activated lymphoma cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To characterize the transcription factors in megakaryocytic cells that could bind to these two regulatory regions , we performed Northern blot analyses , which showed the presence of ets 1 , elf 1 ( which is thought to be restricted to T cells ) , NF IL3A and AML 1 mRNAs , as well as c fos , jun B , and jun D , but not c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Pretreatment with the four preventive agents commonly inhibited TNF alpha mRNA expression and TNF alpha release in BALB / 3T3 cells induced by a tumor promoter , okadaic acid , whereas the expression of early response genes ( c jun , junB , c fos , and fosB ) was enhanced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using a cell free assay , we have found that freshly isolated lysosomes can take up and degrade c Fos with high efficiency . 5 Fos , the oncogenic counterpart of c Fos , can also be taken up by lysosomes , yet the amount of incorporated protein is much lower . c Fos uptake is independent of its phosphorylation state but it appears to be regulated by dimerization with differentially phosphorylated forms of c Jun , while 5 Fos escapes this regulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Suppression by the PKC pathway is not mediated by the proto oncogenes c fos , c jun and junB , as the co transfection of these genes does not block the effects of the PKA stimulator 8 Br cAMP . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hsp 70 and HOx are thought to play a protective role , and the proteins of c jun and c fos constitute the transcription factor activator protein 1 , which is involved in the transcription of many defensive products . ^^^ The expression of hsp 70 the inducible member of the corresponding heat shock gene family of the oxidative stress marker gene heme oxygenase ( HOx ) , and of the immediate early response genes c fos and c jun has been studied in FAO hepatocarcinoma cells depleted of polyamines and exposed to heat shock . ^^^ Inductions of HOx , c jun and c fos were also inhibited . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Downregulation of LPS induced AP 1 was accompanied , and thus possibly explained , by a reduced expression at mRNA level of the two major components of the AP 1 complex , namely c fos and c jun as determined by Northern experiments . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These differences in binding site preference and transcriptional activation may result in the increased transforming ability of the 5 fos oncogene compared with the c fos proto oncogene and may extend the potential target genes beyond those with an AP 1 consensus binding site . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Having shown that the expression of two iTFs , the protein products of the c fos and c jun genes , does not correlate directly to the electrical activity of magnocellular neurones ( Luckman et al . , 1994 ) the expression of leucine zipper iTF mRNAs was measured following different stimuli using combined radioactive and non radioactive in situ hybridization . ^^^ Stimuli that are dependent on brainstem afferents such as parturition and systemic injection of cholecystokinin caused co induction of c fos and c jun in oxytocin neurones . ^^^ Mild osmotic stimulation , a stimulus dependent on forebrain afferents , induced c fos , fos B and jun B , but inhibited c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The PKC activation with phorbol esters induced the expression of c fos , c jun , and junB proto oncogenes in F 9 stem cells . ^^^ It also increased the expression of c jun gene but not c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mutant cells produce a truncated M ( r ) 29 , 000 protein that interferes with the function of normal c Jun ( and c Fos ) proteins through a quenching mechanism . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ACTH and IGF 1 increased c fos and jun B mRNA levels early with later increases in the levels of mRNA for the ACTH receptor and the three steroidogenic enzymes , and enhanced steroidogenic responses to both ACTH and Ang 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This protein does not interact with c Fos or a non repressing GR mutant and expressed in mammalian cells does not substantially affect AP 1 or GR activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogene c fos ( the cellular homolog of 5 fos , Finkel Biskis Jenkins ( FBJ ) murine osteogenic sarcoma virus ) encodes a major component of the activator protein 1 ( AP 1 ) transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There was no temporospatial overlap of cyclin D 1 expression with the expression of the immediate early genes c fos , c jun , and mkp 1 , a result which is clearly distinct from findings in sympathetic ganglion neurons undergoing programmed cell death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We used the protein products of the immediate early genes ( IEGs ) c fos , and c jun as markers of neural activation in order to determine whether a sub population of LHRH neurons is differentially activated by mating and whether non LHRH neurons in specific forebrain regions are selectively activated at different times during the mating induced preovulatory LH surge . ^^^ In Experiment 2 , estrous females were perfused 1 . 5 h or 8 . 0 h after either receiving one 5 min intromission or being placed alone in a testing cage , and the brains were processed for LHRH and c Fos like ( DCH 1 , Dr Gerard Evan ) , c Jun like ( Jun IR ; Oncogene Ab 2 ) or Egr 1 like ( Egr IR ; Santa Cruz ) immunoreactivity . ^^^ Although the LHRH system is presumably activated throughout the duration of the 12 h preovulatory LH surge , c Fos and c Jun immunoreactivity in LHRH neurons is augmented only transiently . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of c fos and c jun in the stretched latissimus dorsi muscle of the rabbit : responses to duration , degree and re application of the stretch stimulus . ^^^ The mRNA levels of the proto oncogenes c fos and c jun were measured in the rabbit latissimus dorsi ( LD ) muscle in response to the application of various stretch regimes in vivo . ^^^ It was shown that it was necessary for the stretch to be applied continuously over 1 h in order to achieve full induction of c fos and c jun mRNA at 1 h . ^^^ In addition , a correlation was demonstrated between the degree of stretch imposed on the LD and the induced levels of c fos and c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos and c jun expression in human endometrium and myometrium . ^^^ In various other estrogen responsive cells , estrogen induces transient expressions of c fos and c jun mRNAs . ^^^ We examined c fos and c jun mRNA expressions by Northern blotting in paired samples of endometrium , myometrium and leiomyoma tissues obtained from women under various hormonal environments as well as of endometrium and myometrium at term pregnancy . ^^^ In nonpregnant endometria , strong expressions of c fos ( 2 . 2 kb ) and of c jun ( 2 . 7 kb and 3 . 2 kb ) were detected both in the follicular and luteal phase of the menstrual cycle , and the c fos expression was significantly stronger in proliferative phase endometrium than in the adjacent myometrium . ^^^ In pregnant endometrium and myometrium , both the c fos and c jun mRNA expressions were nearly undetectable , and in pregnant endometrium expressions were significantly lower than those in nonpregnant endometrium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemistry to Bcl 2 , Bax , c Myc , c Fos , Fos related , c Jun , Jun B and Jun D was used to study the involvement of these factors in ionizing radiation induced apoptosis in the cerebellum of the developing rat . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regionally and temporally distinct patterns of induction of c fos , c jun and junB mRNAs following experimental brain injury in the rat . ^^^ Lateral ( parasagittal ) fluid percussion brain injury of mild ( 1 . 0 1 . 5 atm ) and moderate ( 2 . 1 2 . 4 atm ) severity induced expression of mRNAs for the immediate early genes ( IEGs ) c fos , c jun and junB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The dynamics of the induction of estrogen receptor ( ER ) , c jun , c fos and c myc mRNAs by 17 beta estradiol ( E 2 ) was examined in the uterus and vagina of neonatally DES exposed and unexposed ovariectomized adult mice . ^^^ In the uterus , c jun and c fos mRNAs increased in concentration within 1 h after E 2 administration , showing a peak 3 h after the stimulation ; they decreased with time thereafter . ^^^ In the vagina , the concentration of c jun and c fos mRNAs increased rapidly , reaching a peak within 1 h after the stimulation . ^^^ Expression of c jun and c fos mRNAs was greater in both the uterus ( 3 and 6 fold , respectively ) and the vagina ( 18 and 4 fold ) of neonatally DES exposed mice than in controls . ^^^ The ER mRNA and the increased levels of c fos and c jun mRNAs in both uterus and vagina of neonatally DES exposed ovariectomized mice were not further altered by post puberal E 2 and may be related to ovary independent persistent changes in the genital tract . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The immediate early genes c fos and c jun are transcription regulating factors . c fos expression is widely used as a marker of neuronal activation and has been used in this study to identify those neurons , presumably vasomotor neurons , that are activated after interventions that alter blood pressure . c fos and c jun are expressed in the rostral ventral medulla ( RVM ) when the tonically active inhibitory inputs to the RVM are removed , either acutely or chronically , as in the SHR model of gentic hypertension . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In uterine , as well as in mammary tumor cells , estrogen dependent proliferation and differentiation are correlated to a series of biochemical responses , including increased expression of proto oncogenes such as : c fos , c jun and c myc . ^^^ In the model system utilized , the human cell line SK ER 3 , an increase in c fos mRNA and Fos protein without change of c jun and related genes mRNA concentration was observed after short term treatment with 17 beta estradiol ( E 2 ) . ^^^ A significant decrease of c fos , c jun and jun D proto oncogene mRNA levels were found after prolonged hormonal treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study examined fetal alcohol effects ( FAE ) on the induction of the immediate early genes ( IEGs ) c fos , jun B , c jun , and zif 268 mRNAs in the prefrontal cortex , hippocampus , and other brain regions after testing in an alternation task . ^^^ Testing in the alternation task induced a significant elevation of c fos , c jun , jun B , and zif 268 mRNA expression in the prefrontal cortex , hippocampal subfields CA 1 and CA 3 , and several cortical areas . ^^^ However , FAE rats showed a significantly smaller elevation of both c fos and jun B mRNA levels in the orbital , prelimbic , and anterior cingulate regions of the prefrontal cortex ( p < 0 . 05 ) . ^^^ Significant correlations between the mean performance at the 60 sec delay and mRNA expression of c fos , jun B , and zif 268 in the prefrontal cortical regions ( p < 0 . 05 ) were observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 protein complex at 21 days postnatally was composed of JunD , JunB , Fra 2 , FosB and to much lesser extent of c Fos in both cortical areas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the effect of bradykinin on the expression of the proto oncogenes c fos , c jun and c myc and on cell proliferation in the human keratinocyte cell line , HaCaT . ^^^ Bradykinin caused a rapid and transient accumulation in c fos and c jun mRNAs . ^^^ Thus , while in HaCaT cells bradykinin promotes the expression of the proto oncogenes c fos , c jun and c myc , other biochemical events appear to be necessary for cell division . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Indeed , whereas activation of transcription factors such as NF kappa B and increased expression of immediate early genes such as c fos , c jun , egr 1 , and c myc are induced during compensatory regeneration , such changes are not observed during hyperplasia induced by certain primary mitogens . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Apoptosis and delayed expression of c jun and c fos after gamma irradiation of Jurkat T cells . ^^^ The purpose of this study was to determine the role of radiation induced expression of c jun and c fos in radiation induced apoptosis of cells of the Jurkat T cell line . ^^^ This was accompanied by extensive increases in c jun mRNA levels and moderate increases in c fos levels , both occurring at the time of onset of internucleosomal DNA fragmentation . ^^^ Increased c jun and c fos expression was maximum at 8 h after irradiation with a 10 fold increase in c jun and a 2 fold increase in c fos mRNA levels . ^^^ In comparison , stimulation of the Jurkat cells with PMA resulted in rapid induction of c jun and c fos within 1 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive expression of c Fos , Fos related antigens , Jun B and Jun D , as revealed with immunohistochemistry , is higher and more widely distributed in the developing rat brain than in the adult . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blot analysis of nuclear extracts showed that the impaired DNA protein interactions in anergic T cells were associated with poor expression of the inducible AP 1 family members c Fos , FosB , and JunB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Secondly , the protein products of c fos and c jun were localized to determine whether these early immediate genes are activated in this model . ^^^ The proteins glut 1 , GFAP , c fos and c jun were localized by immunohistochemistry . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immobilization stress induces c fos and c jun immediate early genes expression in the heart . ^^^ Immediate early genes ( IEGs ) , such as c fos and c jun are used as tools for detection of cellular activation . ^^^ IMO stress for 30 min induced c fos and c jun mRNAs expression in the myocardium and the smooth muscle layer of the coronary arteries . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results indicated that , the transmission pathways in two groups were just the same ; but the time courses of c fos and c jun expression in KA pretreated group were accelerated asynchronously ; and the synthesis of the proenkephalin mRNA in the Ent was apparently up regulated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
HBx activation of ERKs and JNKs leads to induction and activation of AP 1 DNA binding activity involving transient de novo synthesis of c Fos protein and prolonged synthesis of c Jun , mediated by N terminal phosphorylation of c Jun carried out by HBx activated JNK . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The PPs Wy 14643 , mono ethylhexyl phthalate , clofibrate , and ciprofibrate ethyl ester were found to be potent inducers of immediate early gene expression ( including c fos , c jun , junB , egr 1 , NUP 475 , and to a lesser extent fosB , JE , and KC , with maximal expression seen 1 h after treatment of serum deprived quiescent cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because mesangial cells stimulated by IL 1 beta transiently expressed c fos and c jun nRNAs prior to the expression of MMP 9 , the role of these genes in mediating the IL 1 beta response was further examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of three immediate early genes ( c fos , c jun , and jun B ) was investigated in rat septohippocampal neurons after axotomy by bilateral fimbria fornix transection ( FFT ) . ^^^ In line with the immunocytochemical data , there was a massive induction of c jun mRNA in the axotomized MS neurons as visualized by in situ hybridization histochemistry . c fos mRNA and c fos or jun B IR were not detectable in either unoperated or lesioned medial septal neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since single pretreatment of CsA in the present study had no effect on the PTZ induced induction of c fos mRNA , c jun mRNA , Fos protein nor Jun protein , the inhibitory effects of single CsA administration on PTZ induced TRE binding activity in the brain may be related to the effects of CsA on AP 1 itself . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The products of the proto oncogenes c fos and c jun play important roles in cell growth control , differentiation , and malignant transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , to show evidence of a possible inhibition of AP 1 transcriptional activity in molecular mechanisms of foodborne molecules , known to be negative modulators of carcinogenesis , we established two rat liver epithelial ( REL ) cell lines overexpressing either c fos ( 43C line ) or c jun ( RELcJ 1 line ) oncoproteins . ^^^ All trans retinoic acid ( RA ) abolished the transformation of the 43C line and TPA treated RELcJ 1 cells , suggesting that RA could decrease AP 1 activity in these cells despite c fos or c jun overexpression . ^^^ The c fos and c jun protooncogenes act as transcriptional activator for numerous cellular genes , and the overexpression of these genes may cause malignant transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recently , the expression of various genes , such as c fos , c jun mkp 1 , cyclin D 1 , and hsp 70 was found to be associated with PCD in model systems . ^^^ Most notably , c fos , c jun , and hsp 70 are expressed specifically in CA 1 neurons at survival times shortly preceding cell degeneration in rat models of global ischemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , we investigated with immunohisto chemistry the subcellular distribution of Fos and Jun / AP 1 , the protein products of c fos and c jun proto oncogenes , and compared them with histological changes shown by hematoxylin eosin and by EA 50 stains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The accumulation of mRNA for hsc 70 , hsp 70 , c fos , c jun , and Erg 1 was localized coincidently and was restricted to the ischaemic area of the heart . mRNA for these genes was undetectable at the end of the ischaemic period ( no reperfusion ) . ^^^ After 30 min of reperfusion , accumulation of mRNA for hsc 70 , hsp 70 , c fos , and c jun was detectable and increased with further reperfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the other hand , PMA induced expressions of mRNAs of several subunit members of the AP 1 complex , such as c fos , c jun and jun B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To evaluate the functional integration of neonatal dopaminergic transplants within host brain we studied the postsynaptic effects induced by their stimulation by following the expression of immediate early genes c fos , c jun and egr 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While the induction of c fos and jun B messenger RNAs followed the stimulus intensity , the expression of c jun was repressed at low levels of stimulation . ^^^ A higher level of osmotic stimulation was able to co induce c jun with the c fos , jun B and fos B genes , suggesting that other signalling pathways may then be activated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because of the ability of the transcription factors for activator protein 1 to antagonize GR function , c jun and c fos mRNA levels were examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two activator protein 1 elements in the matrix metalloproteinase 1 promoter have different effects on transcription and bind Jun D , c Fos , and Fra 2 . ^^^ DNA / protein complexes at both AP 1 sites contain c Fos and Jun D proteins , while Fra 2 is present only at the 77 site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Growth factor early response proto oncogenes c myc , c fos , and c jun are induced transiently by both early and late PMA pulses , suggesting that these genes are not involved in the PMA inhibitory effect . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Estrogen induces the expression of c fos and c jun genes in fibroblasts derived from human uterine endometrium . ^^^ The ratio of membrane / cytosolic protein kinase C ( PKC ) activity and the levels of c fos and c jun expressions in uterine endometrial fibroblasts were increased and reached peak levels with the administration of estradiol , but were partially diminished by the addition of progesterone . ^^^ The response of c fos was earlier than that of c jun . ^^^ Twelve 0 tetradecanoylphorbol 13 acetate ( TPA ) increased c fos and c jun expressions in endometrial fibroblasts as estradiol did , and pretreatment with 1 ( 5 isoquinolinesulfonyl ) 2 methylpiperazine dihydrochloride ( H 7 ) reduced the estrogen inducible c fos and c jun expressions . ^^^ Therefore , it is suggested that oncogenes c fos and c jun in uterine stromal cells might be induced by estrogen partly via PKC , involving the interplay of the anti estrogenic effect of progesterone , and there might be a cross talk between estrogen and PKC stimulants for c fos and c jun expressions . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since transactivation by c Fos requires dimerization with a Jun family member to form the active transcription factor AP 1 , we have examined the expression of multiple fos and jun related genes and have correlated their expression with AP 1 DNA binding activity in AtT 20 nuclear extracts after stimulation with CRF . ^^^ Studies with specific antisera directed against c Fos revealed that although no c Fos could be detected in AP 1 complexes in basal cell extracts , c Fos became a prominent component of AP 1 following CRF stimulation , reaching maximal levels by 4 h . ^^^ Despite the fact that AP 1 DNA binding activity remained elevated for at least 24 h after CRF , c Fos was most prominent during the early phase of the response . ^^^ These data demonstrate that CRF is a potent stimulus for corticotroph expression of c fos , jun B and fos B , and suggest that the subsequent increase in AP 1 may play a role in activation of gene expression and / or as a modulator of glucocorticoid receptor function . . ^^^ Specific ribonuclease protection analysis showed that in addition to c fos , mRNA transcripts encoding fos B and jun B were rapidly stimulated in response to CRF , though levels of induced fos B mRNA were 20 40 times lower than c fos or jun B , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Molecular cloning of c jun and c fos cDNAs from porcine anterior pituitary and their involvement in gonadotropin releasing hormone stimulation . ^^^ The presence of the typical transcription factors c Jun , c Fos and cAMP responsive element ( CRE ) binding protein in the porcine anterior pituitary was examined by molecular cloning and their involvement in the membrane signal cascade , especially their roles in gonadotropin releasing hormone ( GnRH ) stimulation , were studied . ^^^ They were identified as porcine c jun and c fos by determining their nucleotide sequences , but a homologue for CREB 341 which is a member of CRE binding protein was not detected in porcine anterior pituitary . ^^^ Reverse transcription polymerase chain reaction ( RT PCR ) analysis was performed to estimate the c jun and c fos mRNA contents in GnRH , forskolin ( cAMP activator ) and tetradecanoyl phorbol acetate ( TPA ; protein kinase C activator ) treated primary cultures of porcine anterior pituitary cells . ^^^ Densitometric quantification demonstrated that GnRH and TPA treatment increased c jun and c fos mRNA levels significantly , whereas forskolin reduced the levels of both . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , OA not only induced c fos and jun D mRNA , components of transcription factor activator protein 1 ( AP 1 ) , with an increase in AP 1 binding activity in the nucleus , but also activated AP 1 dependent gene transcription in the hepatocytes . ^^^ The dose dependent effect of OA on 3 MC induced CYP2A8 expression corresponded to that of OA on c fos and jun D mRNA induction and on the activation of AP 1 dependent gene transcription . ^^^ Treatment with anisomycin and cycloheximide also potentiated 0 . 1 microM 3 MC induced coumarin 7 hydroxylase activity , induced c fos and jun D mRNA expression , and activated AP 1 dependent gene transcription in the hepatocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AII induced cyclin D 1 promoter activity 4 fold , via the AT 1 receptor through an enhancer sequence at 954 base pairs . c Fos and c Jun bound the cyclin D 1 954 enhancer sequence , and the abundance of c Fos within this complex was increased by AII treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of GEO cells with phorbol ester increased u PAR mRNA and the activity of a CAT reporter driven by the wild type but not the AP 1 ( 184 ) mutated u PAR promoter , and this was associated with a strong induction in the amount of Jun D , c Jun , and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In primary myometrial cells treated with phorbol ester , transient increases in c Fos and c Jun protein levels were observed at 2 4 h , followed by significant increases in connexin 43 protein levels at 6 8 h . ^^^ This work provides evidence that transcription of the human connexin 43 gene is induced through protein kinase C activation in uterine smooth muscle cells , and that the induction involves up regulation and activation of c Jun and c Fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of basal c fos and c jun but not of ras oncogenes after Theiler ' s murine encephalomyelitis virus infection of glial cells . ^^^ Constitutive expression of the cellular proto oncogenes c fos and c jun , and in a lesser extent ras , was demonstrated in the glioma cell line C 6 by flow cytometry analysis using specific mono and polyclonal antibodies . ^^^ Basal expression of the products of the early response genes c fos and c jun were increased 66 and 50 % when Theiler ' s murine encephalomyelitis virus ( TMEV ) infected these cells . ^^^ Fetal calf serum and lipopolysaccharide stimulation slightly increases c fos and c jun expression following a slower kinetics . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These data indicate that c fos mRNA is expressed and then AP 1 DNA binding activity is activated . ^^^ Pretreatment of Jurkat T cells with 10 micrograms / ml EGb 761 suppresses AP 1 DNA activation and c fos mRNA expression . ^^^ These results suggest that the step in the signal transduction pathway for AP 1 activation that is inhibited by EGb 761 is upstream to c fos mRNA expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immediate early gene products ( c fos , c jun and their cognates ) act as transcription factors coupling physiologically relevant stimuli to long term responses by binding to the AP 1 site in the promoter region of target genes . ^^^ In this study , AP 1 DNA binding activity , an indicator of the functional form of the c fos transcription factor , was examined in nuclear extracts prepared from these brain regions using an electrophoretic mobility shift assay and a labeled oligonucleotide containing the AP 1 consensus sequence . ^^^ The binding protein was shown to contain c Fos / Fra and c Jun since addition of c Fos / Fra antiserum formed a supershift of the DNA , protein and antibody complex , and c Jun antibody blocked the protein DNA binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ERK , JNK / SAPK and p38 / RK MAP kinase subtypes ( reviewed in [ 1 ] ) are differentially activated in mammalian cells by various stimuli , which elicit induction of immediate early ( IE ) genes , such as c fos and c jun ( reviewed in [ 1 3 ] ) , as well as phosphorylation of histone H 3 [ 4 ] and HMG 14 [ 5 ] . ^^^ Anisomycin and UV radiation have been suggested to induce c fos and c jun transcription via JNK / SAPK mediated phosphorylation of TCF ( ternary complex factor ) , for c fos induction [ 6 8 ] , and c Jun and / or ATF 2 for c jun induction [ 9 11 ] [ 12 , 13 ] . ^^^ By using the p38 / RK inhibitor SB 203580 [ 20 , 21 ] , we show that activation of p38 / RK and / or its downstream effectors are essential for anisomycin and UV stimulated c fos / c jun induction and histone H3 / HMG 14 phosphorylation , whereas JNK / SAPK activation and phosphorylation of c Jun and ATF 2 are insufficient for these responses . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro replicative senescence is characterized by an irreversible growth arrest due to the inability of the cell to induce some key regulators of cell cycle progression , such as c fos and AP 1 , in response to mitogenic stimuli . ^^^ Here we provide evidences that the well preserved proliferative response is likely due to the fact that some pivotal regulators c fos , c jun and AP 1 are still fully inducible , despite a long process of in vivo senescence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Isoproterenol and forskolin both increased immunoreactivity for the protein products of the early response genes , c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To find clues about the mechanism and pathways of PCP action , we studied the effect of systemic PCP administration ( 10 and 50 mg / kg , intraperitoneal ) on the expression of immediate early genes ( IEGs ) ( c fos , c jun , egr 2 , egr 3 , NGFI A , NGFI B , NGFI C , and Nurr 1 ) using in situ hybridization histochemistry . ^^^ In contrast , a delayed induction of c fos , c jun , NGFI A , NGFI B , NGFI C , and Nurr 1 in the posterior cingulate cortex was observed 2 6 hr after PCP , 50 mg / kg . egr 2 and egr 3 were not induced in the posterior cingulate cortex . c fos induction in the cerebellar Purkinje cell layer peaked 2 hr after PCP , 50 mg / kg . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously reported that estrogen dramatically increases galanin gene expression and protein synthesis in the anterior pituitary ( AP ) , while the expression in the uterus ( UT ) of the same animals is transient and similar to the induction of protooncogenes ( c fos , c jun , c myc ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study investigates expression of nitric oxide synthase ( NOS ) , immediate early genes ( IEGs , c jun , and c fos ) , and low affinity nerve growth factor receptor ( LNGFR ) in adult rat spinal motoneurons in response to three conditions of axonal injury : distal axotomy , root avulsion , and root avulsion followed by a peripheral nerve ( PN ) graft implantation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In IL 1 beta , the upregulation of cytokines and receptors was preceded by the upregulation of c fos , c jun , and c myc , and it was inhibited by actinomycin D . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We observed that : ( a ) c jun mRNA expression is upregulated predominantly by UVB ; ( b ) fra 1 and c myc are downregulated by UVB , whereas both are upregulated by UVA ; ( c ) fra 2 and AP 2 are downregulated modestly by UVB , ( d ) c fos is unaffected , and ( e ) optimal regulation of each gene is achieved at environmentally relevant fluences ( 25 100 J / m2 for UVB and 2500 10 000 J / m2 for UVA ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Enhancement of c fos and c jun gene expressions was also observed in uremia . ^^^ Phosphorus restriction prevented increases in the expression of ODC , c fos and c jun observed in uremia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Combined Dex and TGF beta stimulated the expression of c jun and c fos early responsive genes in U 937 cells , although Dex or TGF beta alone did not . ^^^ However , exposure of U 937 cells to the sense oligomer of c jun mRNA or an antisense oligomer of c fos mRNA did not affect the growth inhibition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Factor Xa stimulated DNA synthesis and cell growth in VSMC , not through the phospholipase C protein kinase C pathway because increase of inositol monophosphate ( IP ) accumulation and intracellular Ca2+ concentration was not observed , but probably via the PDGF receptor tyrosine kinase pathway since the pathway ' s components , Ras , Raf 1 , MAPK ( both 42 and 44 kD ) , and the transcription factors , c Fos and c Jun , were activated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The kinetics of JNK activation correlated with the expression of c jun which was transient after stimulation with PMA plus ionophore and prolonged in response to PDTC , which also transiently induced c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays , using antibodies specific for c Fos and c Jun proteins , and competition experiments with various unlabelled oligonucleotides , were performed in order to check the specificity of binding in the observed bands . ^^^ The results using the oligonucleotide containing the unmodified binding sequence and HeLa cell nuclear extract were fully consistent with binding of c Fos and c Jun , whereas the binding to oligonucleotides containing BPDE modified binding sequences was not . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cytochrome P4502E1 and cytochrome P4502B1 / 2B2 catalyzed carbon tetrachloride metabolism : effects on signal transduction as demonstrated by altered immediate early ( c Fos and c Jun ) gene expression and nuclear AP 1 and NF kappa B transcription factor levels . ^^^ Examination of nuclear levels of the heterodimeric c Fos and c Jun AP 1 transcription factor complex revealed a time dependent increase in AP 1 levels . ^^^ We have previously reported that carbon tetrachloride ( CCI 4 ) stimulates c fos , c jun , and Ca ( 2+ ) activated neutral protease gene expression in rat hepatic tissue ( Zawaski et al . , Biochem . ^^^ The proteins c Fos and c Jun constitute inducible transcription factors in signal transduction and regulate the transcriptional activation of a battery of genes involved in cell growth and division . ^^^ The present study was initiated to characterize the role of cytochrome P 450 expression and metabolic activation on the magnitude of immediate early ( i . e . c fos and c jun ) gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , c jun , but not c fos , mRNA transcripts were transiently increased following exposure to hepatotoxic doses of APAP . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PMA increased c Fos and JunD binding activity on an AP 1 binding site within the U 5 region of the LTR , as shown in gel mobility shift assays . ^^^ Taken together , the data indicate that AP 1 binding sites downstream of the transcriptional start site in the HIV 1 LTR are capable of binding c Fos and JunD and may contribute to transactivation of HIV 1 provirus . . ^^^ RESULTS : Cotransfection of HIV 1 provirus and expression plasmids for c Jun or JunB into SW 480 cells resulted in increased p 24 core antigen and this response was markedly increased following PMA stimulation of cells . c Fos or JunD alone did not increase p 24 production but markedly increased p 24 production in PMA stimulated cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although GPEI is trans activated by these oncogenes , it is also active in F 9 embryonal carcinoma cells that lack c Jun protein , suggesting that it can function with some trans activator other than AP 1 ( c Jun / c Fos heterodimer ) . ^^^ It is well known that TRE is activated by two nuclear oncogenes , c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear extracts of FSH stimulated Sertoli cells caused a labeled AP 1 oligonucleotide to form a DNA / protein complex ( i . e . , gel shift ) , indicating activation of the c fos gene and binding of the c fos / jun complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These studies , therefore , have identified a glucocorticoid response unit through which c Fos and c Jun can suppress the expression of BSP in proliferating pre osteoblastic cells and through which glucocorticoids can ameliorate the effects of AP 1 and promote osteoblast differentiation and the associated expression of BSP . . ^^^ A transient induction of both c fos and c jun mRNAs by TPA was observed in both cell populations , together with an associated suppression of BSP mRNA in the fetal rat calvarial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These actions are mediated through angiotensin 2 receptors ( subtype AT 1 ) , which activate the G protein , phospholipase C , diacylglycerol and inositol trisphosphate pathway , to increase the expression of certain protooncogenes ( c fos , c myc and c jun ) and growth factors ( platelet derived growth factor A chain , transforming growth factor beta 1 and basic fibroblast growth factor ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Actinomycin D or a mixture of protein synthesis inhibitors or of antisense oligonucleotides to c fos plus c jun injected intraocularly 1 hr prior to the stimulation period , abolished the light dark differences for phospholipids but not for gangliosides . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These findings suggest that PRL 1 plays a role in neurons and oliogodendrocytes , and that expression of PRL 1 mRNA is regulated by a mechanism different from those of other immediate early genes such as c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression pattern of c sis , c fos and c jun in human placenta and embryofetal organs . ^^^ The expression pattern of c sis , c fos and c jun was investigated in placenta and embryofetal organ specimens from the first trimester . ^^^ RT PCR analysis of c fos and c jun in placentae , staged at four different time periods in pregnancy , allowed to detect the expected fragments in all cases . ^^^ The same was true when c fos and c jun were analyzed at the 13th week of gestation in all the embryofetal organs . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We studied the combined effects of low end diastolic volume ( EDV ) and low systolic ejection pressure ( Pej ) , compared to low EDV and high Pej , high EDU and low Pej , and high EDV and high Pej , on the expression of c fos , c jun , and egr 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis of total RNA on the expression of CAT mRNA as well as potential transcription factors such as c Jun , c Fos , and LFR 1 were performed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
H ras transfection of the rat kidney cell line NRK 52E results in increased induction of c fos , c jun and hsp 70 following sulofenur treatment . ^^^ The effect of the antineoplastic drug sulofenur on the induction of the immediate early genes ( IEG ) c fos and c jun and the stress gene hsp 70 was compared in the rat kidney epithelial like cell line NRK 52E and a derivative H ras transfected ( H / 1 . 2NRK 52E ) cell line . ^^^ The maximum increases for NRK 2E and H / 1 . 2NRK 52E were as follows : c fos , approximately 10 fold and approximately 18 fold ; c jun , approximately 2 . 5 fold and approximately 3 . 6 fold ; hsp 70 , approximately 13 fold and approximately 30 fold . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show here , at the genomic level , that depolarization potentiates AMP driven transcription of a variety of genes including the c fos and c jun proto oncogenes , and the gene for somatostatin , proenkephalin and nerve growth factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive in vivo mRNA expression by osteocytes of beta actin , osteocalcin , connexin 43 , IGF 1 , c fos and c jun , but not TNF alpha nor tartrate resistant acid phosphatase . ^^^ We have developed a technique to investigate osteocyte gene expression in vivo , using the reverse transcriptase linked polymerase chain reaction ( PCR ) , and have shown that they express mRNA for beta actin ( beta ACT ) , osteocalcin ( OC ) , connexin 43 ( Cx 43 ) , insulin like growth factor 1 ( IGF 1 ) , c fos and c jun , but not tumor necrosis factor alpha ( TNF alpha ) or tartrate resistant acid phosphatase ( TRAP ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , serum stimulated myotubes display a typical immediate early response , including the up regulation of c fos , c jun , c myc , and ld 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that both TGF beta 1 and an oxidant , hydrogen peroxide , rapidly increase the expression of c fos and c jun genes and induce cell death by apoptosis ; these effects are inhibited by the antioxidant N acetylcysteine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BACKGROUND : The early phase of glomerular growth in diabetic rats is accompanied by increased c fos and c jun expression . ^^^ FR 139317 treatment was continued for 24 weeks . c myc , c fos , c jun and proliferating cell nuclear antigen ( PCNA ) mRNA expression in rat glomeruli from each group ( n = 7 ) at 4 , 12 and 24 weeks after STZ or saline injection was evaluated . ^^^ RESULTS : Glomerular mRNA levels for c myc , c fos , c jun and PCNA in group 1 increased with the progression of diabetic nephropathy ( 24 weeks : c myc , 4 . 6 fold ; c fos , 3 . 8 fold ; c jun , 4 . 2 fold ; and PCNA , 4 . 4 fold ) . ^^^ FR 139317 treatment attenuated increases in glomerular mRNA levels of these genes ( 24 weeks , c myc , 0 . 4 fold ; c fos , 0 . 4 fold ; c jun , 0 . 5 fold ; and PCNA , 0 . 4 fold ) in group 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Systemic application of pyrethroid insecticides evokes differential expression of c Fos and c Jun proteins in rat brain . ^^^ Expression of the c Fos and c Jun transcription factor was investigated by immunocytochemistry in the thalamus , hypothalamus , hippocampus and cortex of adult rats following intraperitoneal application of proconvulsant doses of the pyrethroid insecticides , cypermethrin and permethrin . ^^^ Cypermethrin induced a strong expression of c Fos and c Jun in all the thalamic nuclei , except the ventro posterior complex and substantia nigra , and in all the hypothalamic nuclei . ^^^ In general , the immunoreactivities ( IR ) persisted for 8 h on their maximal levels , and were still above control levels after 24 h in several thalamic and hypothalamic areas . c Fos IR was strongly increased in all cortical layers with a predominance in the superficial layers 2 4 , whereas c Jun IR was only slightly increased . ^^^ In the hippocampus , cypermethrin induced a weak expression of c Fos , but not of c Jun , in the dentate gyrus and CA 3 area . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
At least three growth regulatory transcriptional modulators are repressed in senescent cells : the c fos component of the AP 1 transcription factor , the Id 1 and Id 2 helix loop helix ( HLH ) proteins that negatively regulate basic HLH transcription factors , and the E2F 1 component of the E2F transcription factor . ^^^ In the case of c fos repression , the resulting decline in AP 1 activity may be exacerbated by an altered ratio of AP 1 components to a protein known as QM or Jif . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our data suggest that prostacyclin is a likely candidate in mediating the effect of hydrostatic compressive stress on bone cells by regulating the level of c fos mRNA , a member of the activator protein ( AP 1 ) complex and potent regulator of osteoblastic proliferation and differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of the accumulation of mRNA encoding members of the AP 1 transcription factor family demonstrated that c fos and junB are also expressed upon stimulation of NK and T cells with IL 2 , but not IL 12 , whereas expression of c jun and junD is not modified by either cytokine . ^^^ Our data provide the first demonstration that IL 12 mediated activation of T and NK cells does not involve expression of members of the immediate early activation genes family ( egr 1 , c fos , and junB ) , AP 1 transcriptional activity , or bcl 2 expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel retardation assays together with supershift analysis revealed that PDTC induced the binding of c fos and c jun to a consensus activating protein 1 ( AP 1 ) binding site located at position 284 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The intracellular cascade of events activated by peptides was investigated by Northern blot and PCR analysis of expression of early genes ( c fos , c jun , c myc ) and other proteins ( p 53 , SGP 2 bcl 2 , HSP 70 , Ich 1 ) potentially involved in apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemical analysis of c Fos and c Jun in retinoblastoma . ^^^ We have examined by immunohistochemistry the c Fos and c Jun proteins in five cases of retinoblastoma in order to evaluate eventual alterations in their expression in vivo , possibly related to a gene mutation or to loss of Rb negative control . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : Compared with the control eyes , analysis of triplicate samples from the inflamed eyes showed a significantly higher expression index corresponding to the proto oncogenes c fos , c jun and Ha ras , interleukin 2 and heat shock protein Hsp 27 and a significantly lower index corresponding to transforming growth factor beta ( TGF beta ) ( p < 0 . 05 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , the basal activity of TRE was found to be essential to the stromelysin induction , since ( 1 ) mesangial cells stably expressing a transdominant negative mutant of c Jun , which effectively suppressed both basal and inducible TRE activity , exhibited the blunted expression of stromelysin in response to IL 1 beta , whereas ( 2 ) transfection with a c fos antisense gene , which suppressed only the inducible TRE activity , did not affect the stromelysin induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Strong c Jun immunoreactivity , but not c Fos expression , was observed in typical apoptotic cells in medulloblastomas , central neuroblastomas , malignant astrocytomas and glioblastomas , and in lymphocyte like cells bearing nuclear fragmented DNA in medulloblastomas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The importance of c fos and related AP 1 activity in GM CSF signalling was suggested by a tight correlation between GM CSF dependent activation of the c fos promoter and cell proliferation and by the inhibitory effect of a trans dominant c fos mutant on cell growth . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos , jun D and pp60c src+ mRNAs in the developing and grafted rat striatum . ^^^ Expression of the mRNAs of the proto oncogenes pp60c src+ , c fos and jun D were studied using in situ hybridisation histochemistry in the developing striatum and in striatal grafts . ^^^ A different mode of expression was observed in the transplanted striatum which was unique to each particular gene . jun D and pp60c src+ were expressed for a longer time period in the grafted primordial cells than in normal development , whereas no c fos expression could be detected in the grafts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This behavioural paradigm caused region and gene specific increases of c fos , jun B , c jun and zif 268 messenger RNA in the hippocampus as determined by semi quantitative in situ hybridization histochemistry . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dermatotoxic chemical stimulate of c jun and c fos transcription and AP 1 DNA binding in human keratinocytes . ^^^ In the present studies , we demonstrate that increases in AP 1 DNA binding activity , as well as c jun and c fos mRNA levels , occur in human keratinocytes in response to diverse dermatotoxic chemicals , including phenol and arsenic as well as phorbol ester , the latter employed as a positive control . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of immediate early ( IE ) response genes , such as egr 1 , c fos , and c jun , occurs rapidly after the activation of T lymphocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The established ability of the GR to antagonize AP 1 activity led us to examine the regulation and inducibility of c fos and c jun in these cells . ^^^ In A 5 cells , stimulation with factors that activate the serum response element on the fos promoter and induce c fos mRNA had little effect on AP 1 activity , whereas treatment with 12 O tetradecanoylphorbol 13 acetate , which acts at the fos AP 1 binding sequence site on the fos promoter , efficiently induced c fos mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure to this novel environment leads to widespread upregulation in the gene expression of c fos , NGFI A and NGFI B ( the nerve growth factor induced genes ) , but not c jun nor jun B as shown by in situ hybridization and northern blot analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulators of the cell cycle and transcription , such as retinoblastoma , c fos , and c jun genes , were also greatly underexpressed in IcDNA compared with PcDNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Under the same conditions , PDTC by itself or in combination with TNF alpha , enhanced the DNA binding activity of AP 1 , as well as c fos and c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of intracerebroventricular ( i . c . v . ) injections of angiotensin 2 ( Ang 2 ) on the expression of inducible transcription factors ( ITF ) ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 ) in the brain of conscious rats were assessed immunohistochemically using polyclonal antisera . ^^^ Ang 2 ( 1 , 10 , 100 ng ) induced after 90 min a dose dependent expression of c Fos , FosB , c Jun , JunB and Krox 24 , which was confined to four specific brain areas , namely the subfornical organ ( SFO ) , median preoptic area ( MnPO ) , paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . ^^^ In spontaneously hypertensive rats ( SHR ) but not in Wistar rats with nephrogenic hypertension due to aortic banding ( WIab ) , the Ang 2 induced expression of c Fos , and c Jun was enhanced in all four areas when compared to normotensive Wistar Kyoto ( WKY ) and Wistar ( WI ) rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Growth factors induce the expression of the immediate early gene products MAP kinase phosphatase 1 ( MKP 1 ) , c Fos and c Jun . ^^^ Ro 31 8220 inhibits growth factor stimulated expression of MKP 1 and c Fos but strongly stimulated c Jun expression , even in the absence of growth factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phospholipase D activation in hepatocyte growth factor stimulated rat hepatocytes mediates the expressions of c jun and c fos : involvement of protein tyrosine kinase , protein kinase C , and Ca2+ . ^^^ HGF , phorbol myristate acetate ( PMA ) and a DG analog , oleylacetylglycerol ( OAG ) , activated the expression of c jun and c fos messenger RNAs ( mRNAs ) . ^^^ Butanol and propranolol at concentrations which effectively inhibited the formation of DG , suppressed HGF induced expression of c jun and c fos mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , the induction of the cellular protooncogenes c fos and c jun by Cd2+ was studied in PC 12 cells . ^^^ A dose of 0 . 5 microM Ca2+ sufficed to induce the c Fos and c Jun proteins within 30 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NF kappaB p 50 and p 65 , AP 1 c Fos and c Jun , and E2F1 , and inhibits their transcriptional activity . p 202 also binds pRb , the retinoblastoma protein , and if overexpressed it retards cell proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both 12 and 15 hydroperoxyeicosatetraenoic acids induced the expression of c Fos and c Jun protein and increased activating protein 1 ( AP 1 ) activity , as measured by AP 1 DNA binding and AP 1 dependent human collagenase promoter driven chloramphenicol acetyltransferase reporter gene transcription . ^^^ Hydrogen peroxide and arachidonic acid also induced the expression of c Fos and c Jun protein and AP 1 activity . ^^^ Nordihydroguaiaretic acid , an inhibitor of the lipoxygenase pathway , significantly inhibited both hydrogen peroxide and arachidonic acid stimulated c Fos and c Jun protein expression and AP 1 activity . ^^^ We have previously reported that hydrogen peroxide , an active oxygen species and a cellular oxidant , induces c Fos and c Jun mRNA expression and DNA synthesis in vascular smooth muscle cells and that these events require arachidonic acid release and metabolism through the lipoxygenase pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CREB binding protein ( CBP ) functions as a coactivator molecule for a number of transcription factors including CREB , c Fos , c Jun , c Myb , and several nuclear receptors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of vascular endothelial growth factor ( VEGF ) has been implicated in brain tumor angiogenesis , and the promoter region for the VEGF gene contains several SP 1 and AP 1 ( c Fos and c Jun ) binding motifs . ^^^ Among eight human glioma cell lines , cellular mRNA levels of transcription factors SP 1 and AP 1 ( c Fos and c Jun ) were found to be closely correlated with those of VEGF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In fact , depletion of the endoplasmic reticulum from calcium induces metabolic changes resembling , in many respects , those produced by transient cerebral ischemia : it causes an inhibition of the activity of the eucaryotic initiation factor elF 2 alpha ( by phosphorylation ) , a disaggregation of polyribosomes and thus an inhibition of global protein synthesis , and an increased expression of certain genes such as transcription factors ( c fos and c jun ) and the glucose related protein grp 78 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Melatonin was able to significantly inhibit forskolin stimulated induction of c fos and jun B mRNA whilst forskolin had no effect upon c jun or jun D . ^^^ Serum induced c fos and c jun , but melatonin was unable to affect these changes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We evaluated the expression of early response proto oncogenes ( c fos and jun B ) , tissue specific genes ( proline rich protein [ PRP ] and kallikrein ) , and proteolysis linked utiquitin gene following exposure to 15 Gy irradiation alone or in combination with beta adrenergic stimulation of the rat submandibular glands . ^^^ Irradiation alone was found to induce expression of the jun B but not the c fos proto oncogenes . ^^^ The combination of irradiation and beta adrenergic stimulation by isoproterenol induced earlier expression of jun B and profound expression of the c fos proto oncogene in comparison to irradiation alone . ^^^ We observed that the expression of the genes whose regulation is associated with DNA damage ( i . e . jun B and c fos ) was enhanced by irradiation alone or in combination with isoproterenol administration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Experiments were designed to clarify the role of c Jun / c Fos and of putative phorbol 12 myristate 13 acetate ( PMA ) responsive elements ( TREs ) in the induction of plasminogen activator inhibitor 1 ( PAI 1 ) gene transcription in the human hepatoma cell line HepG 2 by activators of protein kinase C ( PKC ) . ^^^ Treatment of HepG 2 cells with the phorbol ester PMA or serum rapidly and transiently increased c Jun and c Fos mRNA and protein levels prior to PAI 1 induction . ^^^ An essential role of c Jun and c Fos in basal and PMA stimulated transcription of the PAI 1 gene is demonstrated by our finding that antisense c jun and c fos oligodeoxynucleotides both strongly reduced basal and PMA stimulated PAI 1 synthesis . ^^^ The protein binding activity to the TRE between positions 79 and 72 shows very strong PMA induction of an unknown factor , which is not related to c Jun or c Fos . ^^^ The amount of the faster migrating complex is enhanced more than 30 fold in PMA treated cells , due to a strongly increased binding of c Jun homodimers and , to a minor extent , to binding of c Jun / c Fos heterodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of the induced binding complexes indicates that c fos , c jun , and ATF 2 were present , but also two additional jun family members , JunB and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , treatment with dexamethasone exacerbated the expression of BDV RNA , which was paralleled by a similarly elevated expression of mRNAs for egr 1 , c fos , and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In a previous study , we have shown that treatment of mouse hepatoma cells with TCDD or B ( a ) P results in an increase in mRNA levels of the immediate early protooncogenes c fos , c jun , junB , and junD , and the concomitant increase of the DNA binding activity of the transcription factor AP 1 , a dimer of FOS and JUN proteins . ^^^ In mouse hepatoma Hepa 1 cells , which have Ah receptor ( AHR ) and Ah receptor nuclear translocator ( ARNT ) proteins , inclusion of TRE , SRE , and the AhRE motifs from c jun and junD , but not CRE or the AhREs from c fos , fosB , and junB , causes a large TCDD dependent increase in luciferase expression . ^^^ In agreement with these results , c jun and junD , but not c fos , fosB , and junB AhREs , competed with a canonical Cyp1A1 AhRE for binding to the AHR ARNT heterodimeric complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An early event in AP 1 induction by ultraviolet radiation is activation of Jun kinases ( JNKs ) , which mediate the induction of the immediate early genes c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We studied the expression of proto oncogene mRNAs : c fos ; c jun ; fos B ; jun B ; jun D in injured corneal epithelium using in situ hybridization . ^^^ Moreover , we examined immunolocalization of c Fos and c Jun protein products to elucidate the transcriptional activation prior to the onset of migration in corneal epithelium . ^^^ Frozen sections were processed for in situ hybridization with c fos , c jun , fos B , jun B and jun D mRNAs or were stained with anti c fos and anti c jun antibodies . ^^^ RESULTS : Fifteen min after the epithelial ablation , weak signals for c fos and c jun mRNAs were detected in the corneal epithelium surrounding the wound . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A trend to reduced c fos mRNA up regulation , which did not reach significance , was also found , whereas the increase in c jun mRNA after kainic acid was similar in eu , hypo and hyperthyroid rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest that TNF alpha , probably acting through ceramide formation , stimulates the binding of both c fos and c jun to the AP 1 element upstream of exon 1 . 4 . ^^^ Levels of c fos and c jun proteins also were increased by TNF alpha or ceramide in the presence of DEX . ^^^ In addition , binding activity was competed by both anti c fos and anti c jun sera . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , because fosB and c fos can be present in the SCN at the same time after a light pulse , these studies indicate the potential for interactions with each other and with members of the Jun family in the regulation of the circadian timing system . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the presence of CGRP , c fos and junB mRNAs accumulated in microglial cultures , whereas no significant change in c jun and TIS 11 mRNAs occurred . ^^^ In contrast to the selective induction of c fos and junB by CGRP and forskolin , ATP led to the accumulation of all four immediate early genes studied , i . e . , c fos , junB , c jun , and TIS 11 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Perhaps most interestingly , vandate induced mitogenesis is associated with the selective induction of c jun and junB expression without significantly inducing c fos or c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of human neuroblastoma SH SY5Y cells to ethanol for 2 4 days caused a dose dependent increase in c jun and junD mRNA levels , whereas mRNAs for c fos , fosB and junB were not detectable in control or ethanol treated cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos , c jun , junB and junD mRNA and AP 1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) and its relationship to cell death , mutation induction and chromosomal instability . ^^^ However , for MMS and UV light , which was included in this study for comparison , c fos , c jun , junB and junD mRNA as well as AP 1 induction paralleled the dose response for induction of cell killing effects , recombination and chromosomal breakage indicating that increased expression of Fos and Jun is related to the generation of MMS and UV induced genetic changes . ^^^ An early and immediate response of cells upon irradiation with UV light and various other forms of genotoxic stress is the induction of the proto oncogenes c fos and c jun . ^^^ To address the questions of whether ( a ) methylating agents that are powerful carcinogens are effective in induction of fos and jun mRNAs , ( b ) induction is affected by the repair capacity of the cells , and ( c ) induction is accompanied by genotoxic effects , the levels of c fos , c jun , junB and junD mRNA were analysed in isogenic Chinese hamster cell lines deficient ( phenotypically Mex ) and proficient ( Mex+ ) for the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) after treatment with N methyl N ' nitro N nitrosoguanidine ( MNNG ) and methyl methanesulfonate ( MMS ) . ^^^ Most responsive were c fos and c jun ( up to 80 fold increases in mRNA level ) whereas junB ( up to ninefold ) and junD ( up to twofold ) displayed an intermediate and weak response , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Decreased expression of the c Fos , but not Jun B , transcription factor in the auditory pathway of the rat after repetitive acoustic stimulation . ^^^ Between the 21st and 34th postnatal days , male rats received an acoustic stimulus every second day , and the expression of c Fos and Jun B proteins was compared with rats that received only a single acoustic stimulus at postnatal day 34 . ^^^ The numbers of neurons immunoreactive to c Fos and Jun B were studied 2 h after the last or acute stimulus , respectively , in the ventral cochlear nucleus ( VCN ) , dorsal cochlear nucleus ( DCN ) and inferior colliculus ( IC ) . ^^^ In contrast to c Fos , repetitive stimulation did not significantly lower the number of Jun B expressing neurons . ^^^ These findings indicate that independent intraneuronal pathways terminate on the induction of c Fos and Jun B expressing genes during the juvenile maturation of the acoustic pathway and that chronic exposure of acoustic events alters the program of intraneuronal gene expression by reducing transcriptional activities with subsequent stabilization at the genetic level . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of the HPV 16 enhancer activity by Jun B and c Fos through cooperation of the promoter proximal AP 1 site and the epithelial cell type specific regulatory element in fibroblasts . ^^^ The promoter proximal AP 1 site was required for transactivation of the LCR by Jun B : c Fos , but the site itself was not sufficient for the maximal response . ^^^ The proposed cell type specific regulatory element that harbors binding sites for NF 1 as well as TEF 1 and PEA 3 motifs , but neither other AP 1 sites nor the proximal enhancer region , could augment the transcriptional response of the promoter proximal AP 1 site to Jun B : c Fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , expression of active PI 3 kinase did not induce the Ras / Rac / Rho signalling pathways that regulate gene transcription controlled by the c fos promoter , the c fos serum response element or the transcription factors Elk 1 and AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoblotting using anti c Fos antiserum revealed the specific attenuation of AP 1 , although total protein synthesis was not affected . ^^^ Since the level of c fos mRNA expression stimulated by KA remained constant even after exposure to SNP , the AP 1 attenuation can be post transcriptionally induced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also observed that AP 1 , a transcriptional factor , plays an important role in the signal pathway for expression of RARalpha , RARgamma , and RXRalpha genes stimulated by TGF beta 1 because stimulation of the expression of these genes in the cytokine treated cells was markedly inhibited by a mixture of antisense c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Temporal and cell type specific expression of c fos and c jun protooncogenes in the mouse uterus after estrogen stimulation . ^^^ Employing immunohistochemistry and in situ hybridization , we studied the temporal and cell type specific localization of c Fos and c Jun proteins and the corresponding messenger RNAs ( mRNAs ) elicited by a single 17beta estradiol ( E 2 ) injection in the uteri of castrated adult mice . ^^^ Present results suggest that transient increase of c Fos and decrease of c Jun protein at the early phase and coexpression of these proteins at the late phase contribute the proliferation of endometrial epithelium in mature mice . ^^^ Furthermore , c Fos and c Jun expression in the vascular endothelium at the early phase may participate in the uterine imbibition . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It may function as an activator of c Fos and c Jun transcription factors and as a repressor of the parathyroid hormone ( PTH ) gene by binding to the negative Ca ( 2+ ) response elements ( nCaRE ) in its promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that As3+ , but not As5+ , which is toxic but not carcinogenic , is a potent stimulator of AP 1 transcriptional activity and an efficient inducer of c fos and c jun gene expression . ^^^ This phosphatase activity appears to be responsible for maintaining low basal JNK activity in non stimulated cells and its inhibition may lead to tumor promotion through induction of proto oncogenes such as c jun and c fos , and stimulation of AP 1 activity . ^^^ Induction of c jun and c fos transcription by As3+ correlates with activation of Jun kinases ( JNKs ) and p38 / Mpk2 , which phosphorylate transcription factors that activate these immediate early genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although BAF blocked apoptosis in sympathetic neurons , it did not prevent the fall in protein synthesis or the increase in the expression of c jun , c fos , and other mRNAs that occur during neuronal PCD , implying that the ICE family proteases function downstream of these events during PCD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We constructed plasmids encoding the sequences for the bZip modules of c Jun and c Fos which could then be expressed as soluble proteins in Escherichia coli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Levels of nuclear c Fos and c Jun proteins , components of the AP 1 complex , showed a prominent decrease already after 12 h in differentiation medium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cyclosporin A enhances the calcium dependent induction of AP 1 complex and c fos mRNA in a T cell lymphoma . ^^^ Therefore , calcineurin negatively regulates Ca ( 2+ ) stimulated AP 1 activity principally at the c fos induction level . ^^^ This activity was shown to involve c Fos , c Jun and JunB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using primary cultures of rat hippocampal neurons , we found that exposing the cells to cycloheximide allowed subsequent activation of BDNF mRNA expression , although activation of AP 1 DNA binding activity resulting from the c fos induction was abolished . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of mRNA expression of the genes c jun , c fos and c myc correlated well with SAPK induction , but not with cell cycle inhibition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All three sequences contain basic and leucine zipper regions characteristic of the c Fos and c Jun family of transcription factors , but the remainder of the sequences are unrelated to this family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Blots of total RNA extracted from neuronal and astroglial cells exposed to PrP 106 126 for between 1 h and 7 days were hybridized with probes recognizing c fos , c jun , c myc , p 53 , hsp 70 and bcl 2 mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ACTH induces the proto oncogenes c fos and c jun , but inhibits the expression of the c myc proto oncogene . ^^^ PMA , on the other hand , induces equally well c fos , c jun and c myc . ^^^ We hypothesize that ACTH promotes G 0 > G 1 transition by induction of c fos and c jun and blocks G 1 > S transition by c myc inhibition . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analyses of mRNA expression of genes involved in apoptosis revealed decreased c myc and increased bcl 2 , c fos , and c jun mRNAs within three to six hours after treatment . ^^^ Western analyses showed increased c Jun , c Fos , and Bcl 2 protein levels . ^^^ Analyses of bcl 2 , c myc , c jun , and c fos mRNA levels in cells receiving VES + RRR alpha tocopherol treatments showed no change from cells receiving VES treatments alone , implying that these changes are correlated with VES treatments but are not causal for apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the proteins ( C FOS and C JUN ) encoded by the immediate early genes c fos and c jun was investigated in the brains of rats undergoing ethanol withdrawal . ^^^ Maximal C FOS expression occurred 15 hr after withdrawal while C JUN was maximal at 24 hr . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The immediate early genes , c fos , c jun and junB were observed to be bilaterally induced in the cortex and hippocampus as early as 5 min following lateral fluid percussion ( FP ) brain injury in the rat . ^^^ While levels of c fos and junB mRNA returned to control levels by 2h , c jun mRNA remained elevated up to 6h post injury . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the nervous system , genes have been identified which either 1 ) promote apoptosis : Bax , Bcl xS , c fos , c jun , p75NGFR and ICE like proteases , or 2 ) block apoptosis : Bcl 2 and Bcl xL . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The specific induction of immediate early genes ( c fos , jun B ) within SCN by light pulses during the subjective night suggests the participation of these genes in the process of cellular entrainment by the photic input . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Slight expressions of the c jun gene were observed in unstimulated cardiac myocytes , and Ang 2 increased expressions of the c jun gene as well as the c fos gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It induced c jun and c fos gene expression in JB 6 variants but to different extents , suggesting that it mediates its effects via genetic epigenetic mechanism ( s ) . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CSF 1 is required throughout G 1 to ensure entry of bone marrow derived macrophages into S phase , and persistent CSF 1R kinase activity is necessary to the expression of both immediate early ( e . g . , c fos , c jun , and c myc ) and delayed early ( e . g . , D type cyclins ) response genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One hour following a single dose of 2 or 15 Gy the expression of c fos and zif 268 but not of c jun mRNAs was induced in a scattered cell population in the lateral striatum , whereas in the piriform cortex the expression of zif 268 mRNA was decreased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of early steps associated with growth inhibition indicated that : ( a ) similar to ET 1 , forskolin decreased c jun mRNA induction without affecting c fos and krox 24 mRNA expression ; ( b ) ET 1 , sarafotoxin S6C , as well as forskolin , reduced activation of both c Jun kinase and extracellular signal regulated kinase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of aging on the basal expression of c Fos , c Jun , and Egr 1 proteins in the hippocampus . ^^^ The protein products of c fos , c jun , and egr 1 genes were visualized immunohistochemically in the rat hippocampus of young adult ( 4 month old ) and old rats ( 20 month old ) . ^^^ In the young adult rat brain , basal levels of c Jun and Egr 1 but not c Fos were detected within the hippocampal formation . ^^^ In contrast , basal expression of c Fos and c Jun as well as astrocyte density within the dentate gyrus were not affected by aging . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , functional activation of brain regions was measured by the induction of c fos and c jun mRNA following exposure to a novel open field . ^^^ Rats were then immediately sacrificed and their brains were examined for c fos and c jun mRNA using in situ hybridization . ^^^ Autoradiogram analyses showed that open field exposure induced c fos mRNA throughout the brain , while c jun mRNA was induced in a few brain regions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibody treatment prevented CCl 4 mediated increases in early immediate gene expression associated with liver regeneration , including expression of c jun and c fos proto oncogenes , as well as DNA binding of the activator protein 1 ( AP 1 ) nuclear transcription factor . ^^^ Consistent with the above observations , injection of recombinant TNF alpha into control mice induced rapid expression of c jun and c fos proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because both fra 1 and junB overexpression negatively interferes with c jun / c fos trans activation of AP 1 responsive genes , our results suggest that the observed block in viral transcription is mainly the consequence of an antioxidant induced reconstitution of the AP 1 transcription complex . ^^^ Irrespective of enhanced c fos expression , c jun was phosphorylated and became primarily heterodimerized with fra 1 , which was also induced after PDTC incubation . ^^^ Since expression of the c jun / c fos gene family is tightly regulated during cellular differentiation , defined reorganization of a central viral transcription factor may represent a novel mechanism controlling the transcription of pathogenic HPVs during keratinocyte differentiation and in the progression to cervical cancer . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IEG mRNAs were detected using [ 35S ] labelled oligonucleotide probes specific for c fos , c jun , NGFI A ( PC 1 ) and PC 3 transcripts . ^^^ While the distribution and apparent basal expression of the different IEGs varied ( NGFI A and c jun > c fos and PC 3 ) , the degree of induction in the dentate gyrus was similar for all IEGs studied ( i . e . 200 300 % ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Suppression of TPA ( 100 ng / mL ) induced c jun and c fos gene expression was also observed in the mouse fibroblast cells pretreated with crocetin ( 30 , 60 , and 120 microM ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A variety of proteins bind to the 3 ' enhancer ( PU . 1 , PIP , ATF 1 , CREM , c Fos , c Jun , and E2A ) , but the mechanism of 3 ' enhancer activity and the proteins necessary for its activity are presently unclear . ^^^ However , mixture of multiple transcription factors ( PU . 1 , PIP , c Fos , and c Jun ) can greatly activate the enhancer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis showed a time dependent increase in the expression of c fos and c jun encoding components of AP 1 , whereas bcl 2 and p 53 mRNA levels remained constant . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : We have previously shown that NFAT 1 orients the two subunits of AP 1 , c Jun and c Fos , on DNA through direct protein protein interactions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the PAD gene ( also called promoter of Alzheimer ' s disease amyloid A 4 precursor gene or amyloid beta protein precursor promoter ) has two AP 1 consensus sequences , and members of the Fos and Jun families are the major components of the transcription factor activator protein 1 ( AP 1 ) , we have investigated the localization of c Fos and c Jun immunoreactivity and its relationship to beta amyloid deposition in the brains of patients with Alzheimer ' s disease and amyloid angiopathy . c Jun , but not c Fos , immunoreactivity is observed in the muscular layer of meningeal and cerebral blood vessels with amyloid angiopathy , and in the soma of glial cells and cellular processes of unknown origin surrounding beta amyloid deposits in the brain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Human c Jun and c Fos leucine zipper domains were examined for their ability to serve as autonomous dimerization domains as part of a heterologous protein construct . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The DNA digests were subjected to Southern analysis using a c DNA probe for one of the following genes : DNA methyltransferase ( DMT ) , c Ha ras , c jun , c fos , and c myc proto oncogenes , p 53 tumor suppressor gene or gamma glutamyltranspeptidase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The TH gene contains an AP 1 site , which interacts with the product of the immediate early gene , c fos . c Fos exhibits activity dependent regulation in the CNS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When G 0 synchronized cells were plated on FN coated dishes , expression of the immediate early mRNAs , c fos , c myc and c jun , was rapidly induced , even in the absence of serum or soluble growth factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We and others have previously shown that the SP family of mammalian transcription factors regulates the transcription of a number of genes whose activities are governed by the product of the retinoblastoma ( Rb ) susceptibility gene , including c FOS , c MYC , TGFbeta 1 , IGF 2 , and c JUN . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The activation of transcriptional factor c Fos / c Jun AP 1 is essential for normal T cell responsiveness and is often impaired in T cells during aging . ^^^ In the present study , we investigated whether aberrancies in the regulation of c fos / c jun at the mRNA or protein level might underlie the age associated impairments of AP 1 in human T cells . ^^^ Using electrophoretic mobility shift assays , the levels of nuclear regulatory proteins recognizing the AP 1 consensus TRE motif , the proximal c jun TRE like promoter element , and the c fos serum response element ( SRE ) were determined in resting and stimulated T cells . ^^^ Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP 1 TRE , c jun TRE , and c fos SRE DNA sequence motifs , age related reductions in the activation of AP 1 were accompanied by decreased levels of c jun TRE and c fos SRE binding complexes . ^^^ These results suggest that underlying aberrancies in the induction of c fos / c jun as well as their nuclear regulatory proteins may contribute to the age related impairments of AP 1 activation in human T cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoblot analyses were performed with specific antibody against BCL 2 , BCL XS / L , BAX , JUNB , c JUN , ICH 1L , c FOS , RB , CDK 2 , and p 53 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c jun , c myc , c fos and c Ha ras was examined and correlated with the various stages of N nitrosodiethylamine ( NDEA ) induced hepatocarcinogenesis in male AKR mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear proteins binding to this site had the characteristics of AP 1 , as judged by the ability to be competed efficiently by a consensus TRE ( 12 . 0 tetradecanoyl phorbol 13 acetate responsive element ) site oligonucleotide and by antibodies to c Fos and Jun proteins . ^^^ Our results demonstrated that c fos , c jun , and junB were differently expressed in the ovine trophoblast around the time of implantation . ^^^ The c fos mRNA and protein were detected at high levels prior to attachment and decreased thereafter , following the pattern of expression of interferon tau , whereas c jun expression was maintained at relatively high levels during the implantation process . ^^^ A striking finding in this study is the temporal correlation between the accumulation of c Fos and c Jun proteins and the expression of the interferon tau ( days 14 and 15 of gestation ) . ^^^ Expression of c fos and jun protooncogenes in ovine trophoblasts in relation to interferon tau expression and early implantation process . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Pituitary adenylate cyclase activating polypeptide stimulates proto oncogene expression and activates the AP 1 ( c Fos / c Jun ) transcription factor in AR 4 2J pancreatic carcinoma cells . ^^^ Both PACAP ( 1 27 ) peptide and PACAP ( 1 38 ) peptide strongly increased the DNA binding activity of the c fos / c jun heterodimer transcription factor AP 1 at 10 nM and also stimulated AP 1 transcriptional activity up to 20 fold in AR 4 2J cells . ^^^ These findings indicate that the mitogenic effect of PACAP mediated via activation of the GTP binding protein coupled PACAP / VIP 1 ( PV 1 ) receptor is linked to the MAP kinase cascade , increased expression of the proto oncogenes c fos and c jun and activation of the heterodimeric transcription factor AP 1 . . ^^^ The present study was designed to investigate signal transduction mechanisms and expression of the proto oncogenes c fos and c jun linked to the mitogenic effect of PACAP in the pancreatic carcinoma cell line AR 4 2J . ^^^ Quantitative reverse transcription PCR revealed that PACAP ( 1 27 ) peptide and PACAP ( 1 38 ) peptide elevated c fos mRNA levels 50 100 fold , whereas c jun mRNA levels increased only moderately ( 2 3 fold ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In both 308 and 10Gy5 cells , c fos , fra 2 , c jun , jun B , and jun D were capable of binding to an AP 1 DNA binding site as determined by antibody clearance gel mobility shift assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although c jun and ornithine decarboxylase induction were also inhibited by pertussis toxin , they were much less sensitive than c fos . ^^^ These results indicate an important for lipid second messengers in mitogenic signalling by insulin and further demonstrate distinct roles for this pathway in the induction of c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the conceptus , the steady state concentrations of c fos , c jun , junB and junD mRNAs were induced , peaking at 0 . 5 hr and returning to base line by 1 to 2 hr in the embryo and by 1 to 6 hr in the yolk sac . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to establish what role members of the activating protein 1 ( AP 1 ) gene families , i . e . , c fos , c jun , junB , and junD , play in thymic apoptosis , we have analyzed changes in their expression in response to three different agents : a glucocorticoid analog dexamethasone , an inhibitor of topoisomerase 2 teniposide VM 26 , and gamma radiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Co transfection with c jun and / or c fos expression plasmids showed that the DRE was unresponsive to the over expressed AP 1 proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Results from super shift and shift Western assays showed that a heterodimer consisting of c Fos and JunB binds to the AP 1 site during hypoxia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Human granulocyte macrophage colony stimulating factor ( hGM CSF ) activates a set of genes such as c fos , jun , myc , and early growth response gene 1 ( egr 1 ) . ^^^ Studies on BA / F3 cells that express hGM CSF receptor ( hGMR ) showed that two different signaling pathways controlled by distinct regions within the beta subunit are involved in activation of c fos / c jun genes and in c myc , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : Cotransfection of cells with Tat / Jun and the AP 1 PL LUC or LTR AP 1 CAT reporter plasmid resulted in a marked increase in reporter gene activity which was comparable with that induced by transfection of cells with several different AP 1 expression plasmids ( e . g . , JunD , JunB , c Fos ) , or that elicited by stimulation of the cells transfected with LTR AP 1 CAT plasmids with phorbol ester or tumor necrosis factor alpha . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that tert butylhydroquinone induces c fos gene expression and indicate the formation of a transcriptionally active AP 1 complex that contains Fos / Jun heterodimer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive binding of further factor proteins to DNA , such as JunD , c Fos and FosB , was detected in several patients whereas the localisation and DNA binding of other factors such as c Jun , RelA / p65 and c Rel was unaltered . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( u PA ) bound to its receptor , u PAR , initiates signal transduction pathways able to induce expression of the activator protein 1 ( AP 1 ) family member c fos [ 1 ] . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the expression of inducible transcription factors ( ITFs ) and the fate of medial septal ( MS ) cholinergic neurons following fornix fimbria ( FF ) transection c Jun , but not c Fos or Krox 24 was induced in nerve growth factor receptor immunoreactive ( NGFr ir ) , parvalbumin negative MS neurons by 48 h and still highly expressed 2 months after transection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cerebral ischemia is known to induce the expression of several immediate early genes ( IEGs ) , including c fos and c jun , which subsequently regulate a number of late effector genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antisense oligodeoxynucleotides ( ODNs ) of c fos and / or c jun were used in this study to investigate the role of Fos and Jun proteins in electroacupuncture ( EA ) induced transcription of the opioid genes , preproenkephalin ( PPE ) , preprodynorphin ( PPD ) and proopiomelanocortin ( POMC ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using antibodies to transcription factors of the Fos and Jun families , we show that the nuclear proteins comprising the inducible TH AP 1 complex include c Fos , c Jun , JunB , and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We compared the effects of an intracerebroventricular injection of angiotensin 2 ( 100 ng ) on the expression of inducible transcription factors c Fos , c Jun , and Krox 24 in the brain of spontaneously hypertensive rats ( SHR ) . in Wistar rats with nephrogenic hypertension induced by aortic banding , and in normotensive Wistar Kyoto and Wistar rats immunohistochemically . ^^^ In SHR , the angiotensin 2 induced c Fos and c Jun expressions were significantly enhanced compared with those in normotensive control strains as well as in secondary hypertensive Wistar rats . ^^^ Injection of isotonic saline or arginine vasopressin ( 100 ng ) as controls did not induce any expression of c Fos , c Jun , or Krox 24 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The majority of the DNA protein complex could be supershifted by an NF IL 6 reactive antibody but not by antibodies for CAAT / enhancer binding protein alpha and delta , c fos , or c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the deoxyadenosine resistant cell lines ( Y 8 and ED 2 ) , the levels of the mRNAs for p 53 and c jun were markedly decreased while the steady state levels for mRNAs for c myc , c fos and jun B were elevated in the Y 8 and ED 2 cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Modulation of the expression of stress response genes belonging to the hsp 70 family ( hsp 70 , hsc 73 , grp 78 ) , growth and cycle related genes ( c myc , c fos , c jun , histone H 3 ) and apoptosis related genes ( p 53 , TRPM 2 , tTG ) was monitored at different time points in the cells that remained adherent to the substrate up to 96 hours after exposure to VP 16 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Irradiation of human keratinocytes with UVB results in the early induction of proto oncogenes c fos and c jun , members of the AP 1 protein family of transcription factors . ^^^ Suppression of UVB induced c fos and c jun expression in human keratinocytes by N acetylcysteine . ^^^ To explore a possible involvement of oxidant stress in triggering this UVB induced early gene response , we investigated in human keratinocytes the effect of N acetylcysteine ( NAC ) , a thiocompound with antioxidant activities , on UVB induced c fos , and c jun expression . ^^^ Preincubation with 1 and 3 mM NAC suppressed c jun and c fos induction by UVB in a dose dependent fashion . ^^^ These applied concentrations of NAC were not toxic to the keratinocytes , as determined by Trypan Blue exclusion assay and completely suppressed c jun and c fos induction by the chemical cadmium chloride ( oxidative stress ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although cadmium caused an early , transient stimulation of c jun and c fos expression and AP 1 binding activity , heat shock failed to alter both protooncogene expression and transcription factor binding , indicating that the stress induced vimentin increase was not the result of AP 1 mediated transcriptional activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The second contains Jun B , c Fos , Fos B and deltaFos B whose levels are low in cycling cells but increase strongly and rapidly after stimulation by serum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased expression of c fos , c jun and LRF 1 is not required for in vivo priming of hepatocytes by the mitogen TCPOBOP . ^^^ The notion that an increased expression of immediate early genes such as c fos and c jun is an absolute requirement for the G 0 G1 transition of the hepatocytes has recently been challenged by the finding that rat liver cell proliferation induced by primary mitogens may occur in the absence of such changes ( Columbano and Shinozuka , 1996 ) . ^^^ To further investigate the relationship between immediate early genes and hepatocyte proliferation , we have compared the hepatic levels of c fos , c jun and LRF 1 transcripts during mouse liver cell proliferation in two conditions : ( 1 ) direct hyperplasia induced by the non genotoxic hepatocarcinogen 1 , 4 bis [ 2 ( 3 , 5 dichloropyridyloxy ) ] benzene , and ( 2 ) compensatory regeneration caused by a necrogenic dose of carbon tetrachloride . ^^^ In spite of a rapid stimulation of S phase by 1 , 4 bis [ 2 ( 3 , 5 dichloropyridyloxy ) ] benzene ( approximately 8 % of hepatocytes were BrdU positive as early as 24 h after mitogen treatment versus 1 % of labelled hepatocytes after 2 / 3 partial hepatectomy ) , no changes in the expression of c fos , c jun and LRF 1 could be observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Epidermoid A 431 cells show changes in the genetic expression of the proto oncogenes c fos and c jun in the clinostat and in sounding rockets . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To this end freshly isolated rat hepatocytes were exposed to either normoxia ( 20 % oxygen ) or to hypoxia ( 1 % oxygen ) and the mRNA levels of the early genes c fos , c jun , c myc and EGR 1 were monitored together with EPO mRNA . ^^^ Isolation of the cells from the livers strongly stimulated the expression of c fos , c jun , c myc and of EGR 1 , whilst EPO gene expression remained unchanged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By contrast , SX did not inhibit the early expression of c jun and c fos , or of c myc , 30 or 120 minutes after PH , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis with specific antibodies against the members of Fos and Jun protein families showed that the NMDA induced AP 1 protein complex consisted predominantly of c Fos and Jun D proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , GTP treatment also increased mRNA levels of the immediate early genes c jun and c fos , as determined by reverse transcriptase coupled polymerase chain reaction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Basal AP 1 transcriptional activity ; AP 1 DNA binding activity ; and the mRNA levels of c fos , the AP 1 coactivator Jun activation domain binding protein 1 , and the retinoid receptor corepressor , the silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) , were lower in tumorigenic 11701 cells than in normal HBE cells . ^^^ Transient transfection of tumorigenic 11701 cells with c fos or CREB binding protein , which is a coactivator of AP 1 and retinoid receptors , enhanced basal AP 1 transcriptional activity but did not alter the effects of t RA on AP 1 transcriptional activity . ^^^ Furthermore , the inhibitory effect of t RA on AP 1 transcriptional activity was not restored in tumorigenic 11701 cells by transfection of c fos , silencing mediator for retinoid and thyroid hormone receptors , Jun activation domain binding protein 1 , or CREB binding protein , suggesting the involvement of other transcriptional coregulators in this retinoid signaling defect . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neuroprotective concentrations of CHX caused only a moderate ( 20 40 % ) reduction in overall protein synthesis , and induced an increase in c fos , c jun , and bcl 2 mRNAs and protein levels as determined by reverse transcription PCR analysis and immunocytochemistry , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By Northern blot analysis , the elevation of mRNA levels were observed in c jun , c fos , c myc and p 53 genes which were induced by apoptotic signals : conversely , expression of bcl 2 was shown to be decreased in the zitter rat brain in contrast to the WTC control rat . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibodies to estrogen receptor , epidermal growth factor receptor , c Fos , c Jun , and Ras proteins , protein kinases involved in receptor tyrosine kinase signal transduction pathway , MEK 1 and phosphotyrosine were utilized in immunocytochemical localization experiments to evaluate temporal expression of these factors in response to estrogen treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the transformation sensitive phenotype of JB 6 clone41 cells is associated with increased expression of the transcription factor AP 1 , we compared c jun and c fos mRNA expression in MnSOD transfected and control JB 6 cells . ^^^ Overexpression of MnSOD led to a significant decrease in c jun and c fos expression in response to treatment with TPA or the oxidant promoter superoxide . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro studies showed that ELG was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Herein , we report the mRNA expression of immediate early genes , c fos , c jun and jun B , which are induced by leptin addition , not only in CHO cells expressing the OBRb , but also in cells expressing one of the short form receptors , OBRa . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis with antisera to c Fos and FRA proteins demonstrated that 4 Fos and the 35 kDa FRA are components of the striatal AP 1 binding complex from sensitized rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The possible relation between stress induced IEG expression and CRF gene transcription was investigated by analysis of stress induced changes in the abundance of c fos , c jun , jun B , jun D , and NGFI B mRNA as well as CRF heteronuclear RNA ( hnRNA ) , which reflects gene transcription , in the rat paraventricular nucleus ( PVN ) by in situ hybridization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Studies on the contribution of c fos / AP 1 to arthritic joint destruction . ^^^ We tested here if arthritic joint destruction was inhibited upon inactivation of the c fos / AP 1 signal by administering short double stranded AP 1 DNA oligonucleotides into mice with collagen induced arthritis to compete for the binding of AP 1 in vivo at the promoter binding site . ^^^ Thus , activation of c fos / AP 1 appears essentially important in arthritic joint destruction . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the immediate early genes c fos , c jun and c myc was normally induced by serum treatment of quiescent cells at the restrictive temperature , whereas expression of cyclins A , D 1 and D 3 was reduced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , we found that AP 1 / c Fos induction was vital in prolonging DP thymocyte life , as judged by increased spontaneous and induced death of DP cells in Fos / mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As revealed by Northern analysis , mRNA levels of c fos , jun B and zif / 268 increased in the hippocampus , while the expression of c jun remained unchanged over a period of 7 h . ^^^ In contrast , only c fos , but not c jun or zif / 268 mRNAs were increased in the cerebellum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The two AP 1 sites bound c Fos / c Jun heterodimers in both unstimulated and LPS stimulated cells . ^^^ Synergistic transactivation of the LPS response element in Drosophila Schneider cells by coexpression of c Fos , c Jun , c Rel , and p 65 or c Jun and p 65 required the transactivation domains of c Jun and p 65 . ^^^ These data indicated that c Fos / c Jun , c Rel / p65 , and Sp 1 regulate TF gene expression in human monocytic cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TGF beta 1 did not affect mitogen stimulated induction of the immediate early genes , c fos , c jun , and Egr 1 in MCs that occurred transiently at 30 to 120 minutes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NAC ( 6 mM / kg body wt ) infused 1 h prior to and 1 h following renal ischemia reduced c fos and c jun expression by 50 and 70 % , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proto oncogene encoded nuclear proteins such as c Fos or c Jun act as transcription factors that may link neuronal excitation to changes in target gene expression . ^^^ Continuous infusion of terminal phosphorothioated c fos antisense ODNs by subcutaneously implanted miniosmotic pumps for 3 days sequence specifically suppressed c Fos protein expression in dorsal horn neurons by about 50 % , while the increase in c Jun immunopositive nuclei was not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Training chicks on a one trial passive task results in a cascade of molecular and cellular processes in two forebrain regions , culminating within 60 90 min in post translational glycosylation of synaptic membrane proteins and expression of immediate early genes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , the pattern of proto oncogenes ( c fos , c myc and c jun ) expression in these cells , upon serum restimulation , resembled that of cell lines that display shorter population doubling times . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of immediate early genes c jun , junB , and c fos was demonstrated during echovirus 1 infection in a human osteogenic sarcoma ( HOS ) cell line . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos , c jun , and c H ras was highly variable during the preneoplastic period and in the tumors , with no consistent increase compared with controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of nerve growth factor treated PC 12 rat pheochromocytoma cells to a modulated radiofrequency field at 836 . 55 MHz : effects on c jun and c fos expression . ^^^ After extracting total cellular RNA , Northern blot analysis was used to assess the expression of the immediate early genes , c fos and c jun , in all cell populations . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using a mouse model of valproate induced neural tube defects , a study was undertaken to examine differential changes in gene expression for selected transcription factor ( Pax 3 , Emx 1 , Emx 2 , c fos , c jun , creb ) and cell cycle checkpoint genes ( bcl 2 , p 53 , wee 1 ) during neural tube closure . ^^^ This accelerated developmental profile is marked by significant elevation of Emx 1 , Emx 2 , c fos , c jun , and creb expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neonatal diethylstilbestrol treatment alters the estrogen regulated expression of both cell proliferation and apoptosis related proto oncogenes ( c jun , c fos , c myc , bax , bcl 2 , and bcl 10 ) in the hamster uterus . ^^^ As part of a project to investigate the molecular and cellular mechanisms responsible for this phenomenon , expression of several proto oncogenes ( c jun , c fos , c myc , bax , bcl 2 and bcl 10 ) was compared in estrogen stimulated uteri from control versus neonatally DES treated hamsters . ^^^ According to immunohistochemical analysis of paraformaldehyde fixed and paraffin embedded tissue sections , levels of c Jun , c Fos , c Myc , Bax , and Bcl 10 proteins were enhanced dramatically in both the luminal and glandular epithelial cells of neonatally DES exposed uteri . ^^^ In conclusion , neonatal DES treatment induced persistent and epithelial cell specific imbalances in the estrogen regulated uterine expression of c jun , c fos , c myc , bax , bcl 2 , and bcl 10 proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Accordingly , PCA 4230 ( 50 microM ) caused a 95 and 90 % decrease in the elevation of c fos and c jun proto oncogenes expression as evaluated by Northern blot analysis of mRNA induced early after serum addition . 8 . ^^^ Flow cytometric studies of DNA content and the down regulation of c fos and c jun proto oncogenes , suggest that the drug is acting at the early G0 / G1 transition phase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNA levels of c fos , c jun , junB and early growth response gene 1 were markedly elevated in the tibial metaphysis as early as 15 min postinjection and returned to basal level by 180 300 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A screening for nuclear protooncogene and tumor suppressor gene related proteins in the myxomycete Physarum polycephalum revealed the existence of homologs of vertebrate c myc , c fos , c jun , p 53 , and retinoblastoma proteins during the synchronous cell cycle or sclerotization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We suggest that increased gene expression of NF kappaB and AP 1 binding activity and up regulation of c fos and c jun may play a role in the mechanism of benzene leukemogenesis . . ^^^ Exposure of HL 60 cells to muconaldehyde resulted in an increase in c fos and c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the uterus , estrogens rapidly and transiently induce the expression of the immediate early genes c fos and c jun in specific cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein tyrosine kinase activity is required for oxidant induced extracellular signal regulated protein kinase activation and c fos and c jun expression . ^^^ The time courses of the hydrogen peroxide stimulated FGFR 1 tyrosine phosphorylation and ERKs activation were followed by induced expression of c fos and c jun . ^^^ Genistein , a potent inhibitor of protein tyrosine kinases , significantly blunted the hydrogen peroxide induced FGFR 1 tyrosine phosphorylation , ERKs activation and c fos and c jun expression . ^^^ PD 98059 , a specific inhibitor of MEK 1 , attenuated the hydrogen peroxide induced ERKs activation and c fos and c jun expression . ^^^ Together , these results suggest that oxidants such as hydrogen peroxide stimulate tyrosine phosphorylation of receptor tyrosine kinases and these , in turn , mediate the down stream signalling events including the recruitment of Grb 2 by the receptor , activation of ERKs and induction of c fos and c jun expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun proto oncogenes by ovine preimplantation embryos . ^^^ The c fos and c jun proto oncogenes are involved in the regulation of gene expression , cell proliferation , differentiation and tumorigenesis . ^^^ Activation of the c fos and c jun proto oncogenes in sheep conceptuses during the period of rapid growth and elongation was examined using reverse transcription and polymerase chain reaction ( RT PCR ) . ^^^ These results suggest that mRNA transcripts of c fos and c jun proto oncogenes were specifically expressed during the period of ovine embryonic elongation and may have a possible role in preimplantation embryonic development of sheep . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Following addition of 10 microM a beta 1 42 the immediate early response gene , c fos , shows a rapid and sustained increase in transcript level while c jun levels increase at a slower rate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recently , H2O2 has been reported to stimulate the activity of the mitogen activated protein kinases ( MAPKs ) ERK and JNK , and the expression of the proto oncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of glutathione S transferase ( GST ) pi and four oncogene products , c Jun , c Fos , c H Ras , and c Myc , in human squamous cell carcinomas of the head and neck was investigated immunohistochemically before and after radiation therapy , to examine whether these oncogene products might be involved in GST pi expression , and also to examine the relationship between their expression and therapeutic response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNA fragmentation and Prolonged expression of c fos , c jun , and hsp 70 in kainic acid induced neuronal cell death in transgenic mice overexpressing human CuZn superoxide dismutase . ^^^ In situ hybridization showed that c fos , c jun , and hsp 70 genes were expressed in the hippocampus , cortex , and other regions of the brain after KA treatment . ^^^ The prolonged expression of c fos , c jun , and hsp 70 in SOD 1 Tg compared with wild type mice may indicate that hippocampal neurons survive longer in SOD 1 Tg than in wild type animals ; however , cell death as well as the seizure threshold , seizure severity and the pattern of regional vulnerability were not affected substantially by increased levels of SOD in the brain . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TPA stimulation of the human GnRH gene is mediated by a consensus AP 1 site located at 402 to 396 bp , TGACTCA , which specifically binds c fos and c jun in Gn 11 and NLT cells and recombinant c jun in gel mobility shift studies . ^^^ In contrast , TPA treatment stimulated expression of a human GnRH luciferase reporter construct , correlating with the expression of the protoon cogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos and c jun mRNA has been examined in the testis of a seasonal breeder ( the frog , Rana esculenta ) during the annual reproductive cycle , using Northern blot analysis along with measurements of plasma levels of estradiol 17 beta and androgens ( testosterone + 5 alpha dihydrotestosterone ) . ^^^ A c fos like transcript of 1 . 9 kb was revealed using a 1 . 1 kb 5 fos probe , while three different transcripts of 3 . 7 , 3 . 4 , and 2 . 7 kb were seen using 1 . 0 kb human ( h ) c jun fragment . ^^^ It is concluded that there is a close correlation between c fos and c jun like expression and testicular activity in R . esculenta . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The aim of our work was to more directly address this question by transfecting more or less differentiated keratinocyte cell lines ( A 431 and HaCaT ) with constitutive expression vectors for c Fos or c Fos + c Jun . ^^^ Our results showed that c Fos expression decreased keratinocyte growth , yet addition of c Jun seemed to revert this c Fos induced growth inhibition . ^^^ Whereas no obvious differentiation program was turned on by c Fos or c Fos + c Jun expression in our tissular model , apoptotic figures were observed and confirmed by in situ DNA fragmentation studies . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To evaluate the hypothesis that Tat ( 65 80 ) modulates the expression of immediate early genes ( IEG ) c jun , c myc , c fos and the tumor suppressor gene p 53 , serum starved A 549 cells were incubated with Tat ( 65 80 ) or heat inactivated Tat ( 65 80 ) at 10 ng / ml . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription factor , SP 1 , and retinoblastoma susceptible gene product , RB , are substrates of SPase while other nuclear factors such as c Jun and c Fos are not . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nucleotide induced signalling in mesangial cells included an increase of intracellular calcium , activation of phosphatidylinositol specific phospholipase C and phospholipase D , inhibition of adenylylcyclase , stimulation of mitogen activated protein kinase and increased expression of the immediate early genes , c fos , c jun and Egr 1 . 5 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Drugs that stimulate dopamine and glutamate receptors have been shown to induce the expression of AP 1 proteins ( such as c Fos and c Jun ) in the striatum and to induce binding of these proteins to AP 1 sites on DNA , leading to the hypothesis that AP 1 mediated transcription contributes to the long term effects of these drugs . ^^^ Although glutamate , dopamine , and forskolin ( an activator of adenylate cyclase ) all induce c fos mRNA and AP 1 binding , we found , surprisingly , that only glutamate induces transcription of a transfected AP 1 driven fusion gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis with specific antibodies against the members of Fos and Jun protein families ( c Fos , Fos B , c Jun , Jun B , Jun D ) revealed that the NMDA induced AP 1 complex was composed predominantly of Jun D and c Fos . ^^^ In contrast , application of AMPA plus cyclothiazide induced an AP 1 transcription with contribution of Jun D , c Fos , Fos B , c Jun and Jun B proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of quiescent mouse fibroblasts with TGF beta 1 and certain other growth factors result in cooperative activation of tissue factor ( TF ) gene transcription , an event accompanied by the rapid entry of c Fos into specific AP 1 DNA binding complexes ( Felts et al . ( 1995 ) Biochemistry 34 , 12355 12362 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mobility shift assays indicated c Fos and Jun D bound to this motif and transfection of the cells with a mutated c Jun , which quenches the function of endogenous Jun and Fos proteins , decreased MMP 9 promoter activity by 80 % . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast acute PDB treatment induced c Fos expression , while having little effect on c Jun . ^^^ RA treatment did not change the expression of Jun family members ; however , it decreased the expression of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Angiogenic oligosaccharides of hyaluronan induced rapid transient up regulation of the immediate early genes c fos , c jun , jun B , Krox 20 and Krox 24 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Steady state levels of c fos , c jun , jun B , and c myc transcripts and proteins were documented by Northern blots of poly ( A ) enriched RNA derived from resected livers and Western blots of total nuclear protein , respectively . ^^^ Despite abrogation of hepatocyte PD changes , proto oncogene mRNA and protein levels in saline and GABA treated rats were either similar or , in the case of c fos and c jun , increased five to sevenfold in GABA treated rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine the role of AP 1 ( fos / jun ) in the regulation of the HDC promoter , gastric cancer ( AGS B ) cells stably expressing the cholecystokinin B / gastrin receptor and the 1 . 8 kb human ( h ) HDC luciferase ( luc ) construct were cotransfected with constructs expressing c fos and c jun . ^^^ Overexpression of c fos and c jun activated the HDC promoter in a dose dependent fashion in 1 . 8 kb hHDC luc / AGS B cells as well as in transfected F 9 embryonal carcinoma cells , which lack endogenous AP 1 activity . ^^^ Gastrin stimulation increased c fos and c jun mRNA abundance and AP 1 dependent transcriptional activity , as assessed by a reporter construct in which the CAT reporter gene is under the control of a 12 O tetradecanoylphorbol 13 acetate response element multimer . ^^^ Finally , overexpression of c fos and c jun activated the hHDC promoter through a downstream cis acting element ( gastrin response element ) , which does not bind AP 1 . ^^^ PMA was unable to activate the HDC promoter in F 9 cells , which were not transfected with c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast to the lack of effect on resorption , estradiol treatment for 30 minutes resulted in steady state mRNA levels of c fos and c jun increasing in osteoclasts from embryonic chickens and decreasing in osteoclasts from egg laying hens . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the cellular transcription factors in tax 1 expressing glial cells that associate with the proenkephalin promoter and herein demonstrate the enhanced interaction and involvement of c Fos / c Jun proteins in the complexes formed at the AP 1 site . ^^^ The comparative electrophoretic mobility shift and ' supershift ' analysis using specific antibodies indicated the enhanced presence of c Fos and c Jun proteins in the DNA : protein complex formed at the AP 1 site . ^^^ The tax 1 induced c Fos protein levels and the concurrently increased association of c Fos / c Jun transcription factors at the AP 1 site imply a strong functional significance in the activation of proenkephalin gene expression in tax 1 expressing glial cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All the known components of chicken AP 1 ( c Fos , Fra 2 , c Jun , and JunD ) were detected in both cell types , but the expression level of c Jun was much higher in LS cells , which are rich in less mature chondrocytes than US cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of basic fibroblast growth factor mRNA after transient focal ischemia : comparison with expression of c fos , c jun , and hsp 70 mRNA . ^^^ Compared to c fos , c jun , and hsp 70 mRNA expression , upregulation of the bFGF mRNA expression was delayed until 6 h after reperfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There were no significant differences in the expression of c fos , c jun , c myc , cyclin D 2 , D 3 , cyclin dependent kinase 2 , cyclin dependent kinase 4 , and p 21 among the clones . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The high DNA binding activity of AP 1 in RA correlated with the expression of c fos and c jun mRNA in situ . ^^^ The expression of c fos and c jun messenger RNA ( mRNA ) was examined by in situ reverse transcription assay . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we report the use of this procedure to prepare probes for the detection of synapsin 1 , p150Glued , neurotensin , c fos , and c jun mRNAs in brain , using both isotopic and non isotopic labeling methods . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with our hypothesis , ricin A chain and alpha sarcin were strong agonists of SAPK / JNK1 and of its activator SEK1 / MKK4 and induced the expression of the immediate early genes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the expressions of c Ha ras , c jun , c fos , c myc genes and p 53 protein in the development of skin tumors induced by chronic exposure to UVB without a photosensitizer using hairless mice . ^^^ A single dose of UVB ( 2 kJ / m2 ) applied to the backs of hairless mice transiently induced overexpression of the early event genes c fos , c jun and c myc , but not c Ha ras , in the exposed area of skin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of c fos and c jun expression by calcitonin in human breast cancer cells . ^^^ These results indicate that CT modulates in BCC the mRNA levels of two important growth related early response genes ( c fos and c jun ) and of two other genes ( timp 1 and 2 ) involved in the control of metastatic events . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine whether the gene encoding the beta subunit of ovine FSH ( oFSHbeta ) is responsive to AP 1 transcriptional complexes , chimeric constructs containing deleted portions of the oFSHbeta promoter fused to a luciferase reporter were transiently transfected along with c Jun and c Fos expression constructs into JAR cells . ^^^ These data , taken together , show that oFSHbeta transcription can be stimulated by c Jun and c Fos proteins via two functionally linked AP 1 like sites in the oFSHbeta proximal promoter and that these sites are likely to be important regulators of FSH production in vivo . . ^^^ Analysis of these deletion constructs revealed that the proximal promoter of oFSHbeta is highly stimulated by c Jun and c Fos proteins ( typically 20 fold with a reporter construct containing oFSHbeta sequences from 215 to +759 bp ) . ^^^ Transcriptional start site analysis using reverse transcription PCR verified that the transcriptional initiation of the 215 bp deletion construct , with or without cotransfected c Jun / c Fos , was the same as that observed in vivo . ^^^ Site directed mutagenesis of the 120 and 83 sites showed that each element was required for stimulation by c Jun and c Fos proteins as well as 12 O tetradecanoyl phorbol 13 acetate in transient transfection assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report herein the construction of CHO cells that stably express the fa type leptin receptor and the characterization of this receptor using mRNA expression levels of the immediate early genes , c fos , c jun , and jun B , which are induced by leptin as a criterion of signal transduction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vivo crypt surface hyperproliferation is decreased by butyrate and increased by deoxycholate in normal rat colon : associated in vivo effects on c Fos and c Jun expression . ^^^ We hypothesized that butyrate decreases and deoxycholate increases crypt surface proliferation in vivo and that these effects are mediated by changes in the expression of the protooncogenes c Fos and c Jun , which are known to regulate proliferation and differentiation . ^^^ Expression of c Fos and c Jun was evaluated by Western blot . ^^^ Butyrate increased colonic expression of c Jun , whereas deoxycholate significantly induced c Fos . ^^^ The concurrently observed effects on colonic c Jun and c Fos expression represent a novel finding and suggest that direct or indirect modulation of protooncogene expression may be the mechanism by which these dietary byproducts regulate proliferation in vivo . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of the rodent striatum to quinolinic acid ( QA , N methyl D aspartate receptor agonist ) induces immediate early gene ( IEG ; c fos , c jun , jun B , zif / 268 ) expression that may extend 12 24 h after injection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The migration of this complex was retarded by c Fos antibody , suggesting that both AP 1 and Vmw 110 are involved in its formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The consequence of PKC dependent JNK inhibition was reflected in c Jun and c Fos mRNA induction following treatment with thapsigargin and Ang 2 . ^^^ Thapsigargin , which only minimally induced c Fos , produced a much greater and more prolonged c Jun response than Ang 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c Fos and c Jun transcription factors are rapidly turned over in vivo . ^^^ The c fos gene has been transduced by two murine oncogenic retroviruses called Finkel Biskis Jenkins murine sarcoma virus ( FBJ MSV ) and Finkel Biskis Reilly murine sarcoma virus ( FBR MSV ) ; c jun has been transduced by the chicken avian sarcoma virus 17 ( ASV 17 ) retrovirus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among a group of immediate early response genes , including egr 1 , junB , c jun , junD , and c fos , only egr 1 stimulation was modulated by changes in medium pH . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proteins of the c Jun , ATF 2 , and c Fos families aggregate to form DNA binding homodimers or heterodimers called activating protein 1 ( AP 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein kinase A pathway inhibits c jun and c fos protooncogene expression induced by the protein kinase C and tyrosine kinase pathways in cultured human thyroid follicles . ^^^ In view of the key role played by the protooncogenes c jun and c fos in the cascade of events leading to cell proliferation and differentiation , we examined whether the antagonism we observed between the pathways could be related to changes in the expression of these genes . ^^^ Both EGF ( 1 50 ng / mL ) and the phorbol ester 12 O tetradecanoylphorbol 13 acetate ( TPA ; 10 ( 11 ) 10 ( 7 ) mol / L ) dose and time dependently stimulated c jun and c fos messenger ribonucleic acid ( mRNA ) expression . ^^^ The c jun and c fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors , chelerythrine and staurosporine , and could not be mimicked by 4alpha phorbol 12 , 13 didecanoate ( a phorbol ester that fails to activate PKC ) , whereas the stimulation induced by EGF was diminished by the PTK inhibitor , genistein . ^^^ TSH induced an increase in c jun and c fos mRNA , which , though significant , was small compared to that elicited by TPA or EGF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also found that a single dose of PGE 2 induces the expression of early response genes ( c fos , c jun , and egr 1 ) in bone marrow cells within these two types of bone . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Sublethal doses of UVB produce strong induction of c jun and c fos transcripts in several cells including human primary keratinocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The chronic administration of 17beta estradiol to male Syrian hamsters for 6 7 months induces kidney tumors which express high levels of c fos , c myc and c jun mRNA compared to surrounding tissue or untreated controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Changes in glutamate receptors , c fos mRNA expression and activator protein 1 ( AP 1 ) DNA binding activity in the brain of phenobarbital dependent and withdrawn rats . ^^^ PB withdrawal seizures were followed by increased expression of c fos mRNA in the hippocampus and cerebral cortex and of c jun mRNA in the cerebral cortex . ^^^ The induction of c fos and c jun mRNA was suppressed by administration of MK 801 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunocytochemistry with specific antisera was used to assess regional levels of five IEG encoded proteins ( c FOS , FOS B , c JUN , JUN B and JUN D ) in a rat model of penicillin induced focal epilepsy . ^^^ The results demonstrated marked induction of c FOS , FOS B , c JUN and JUN B but not JUN D in the cortical epileptic focus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thus , it appears that the differential temporal stimulation of the AP 1 genes by PTH and PMA , particularly an increase in jun B at the same time as c fos and c jun , explains the difference seen in their ability to induce transcription of collagenase . . ^^^ We have demonstrated that maximal mRNA levels of two of the members of this family , c fos and c jun , occur 30 min after stimulation by PTH . ^^^ Phorbol myristate acetate ( PMA ) elicits a similar increase in c fos and c jun mRNAs , but is unable to stimulate transcription of collagenase in these cells . ^^^ To determine whether an increase in jun B at the same time as c fos and c jun would inhibit collagenase gene transcription , we cotransfected an expression vector for jun B with a rat collagenase promoter reporter gene construct . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the early genes c fos and c jun were studied by blot hybridization in the central nervous system of the edible snail at the consolidation stage of a conditioned defensive reflex , with the aim of investigating genomic activity in neurons during learning . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Serial sections of nodules / tumors and normal liver were stained immunohistochemically for BrdU , the oncoproteins c Jun and c Fos , and hematoxylin and eosin ( H & E ) ; or with Periodic acid Schiff ( PAS ) stain , BrdU , and H & E , respectively . ^^^ DCA induced lesions were found to display immunoreactivity to anti c Jun and anti c Fos antibodies , were predominantly basophilic , and contained very little glycogen relative to surrounding hepatocytes . ^^^ TCA induced lesions did not display immunoreactivity to either c Jun or c Fos antibodies . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It stimulates the expression of immediate early genes ( c fos , c jun , and c myc ) , of the tumor suppressor gene p 53 , and of genes coding for the syntheses of protective molecules , including metallothioneins , glutathione , and stress ( heat shock ) proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 family member c Jun enhanced Dex inhibition and estradiol stimulation of transcriptional activation . c Fos potentiated the effect of cotransfected c Jun on estradiol stimulation but not Dex inhibition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 DNA binding activities in all regions at all times after withdrawal were composed of FosB , c Jun , JunB , and JunD . c Fos was detected at all times in the cerebral cortex , at 16 h only in the hippocampus , and from 16 to 72 h in the cerebellum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After stimulating arterial baroreceptors by blood pressure increase due to phenylephrine , c Fos , FosB , c Jun and JunD / choline acetyltransferase ( ChAT ) positive neurons were surveyed in the medulla . ^^^ In the phenylephrine pressor test experiment , we ascertained that in the target neurons fosB was more sensitive to baroreceptor stimulation than any other immediate early genes such as c fos , c jun and junD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BACKGROUND : Induction of protooncogenes such as c fos , c jun , and EGR 1 has been implicated in cellular growth and differentiation . ^^^ Thomas ' 2 solution followed by 40 minutes ' reperfusion resulted in a significant increase in left ventricular c fos , EGR 1 , and c jun messenger RNA levels ( 4 . 0 , 3 . 1 , and 3 . 0 fold , respectively , with Bretschneider solution and 3 . 7 , 2 . 8 , and 2 . 1 fold , respectively , with St . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : The results indicate that the proto oncogenes c fos , c jun and c ets 1 were already activated during the isolation of the cells and then continued to be strongly expressed for a few days . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The prolonged expression of Fos LI in the pars intermedia under black background stimulation and the presence of an AP 1 binding site on the Xenopus proopiomelanocortin gene suggest an important role for c Fos and / or Fos related antigens in the control of the biosynthesis and secretion of alpha MSH by the Xenopus melanotrope cell . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Most strikingly , in the SCG , the trans synaptic induction of TH transcription is transduced by totally different mechanisms , since no AP 1 complex and only minute amounts of c Fos immunoreactivity were detected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AT 1 receptor antagonist can inhibit protooncogenes ( c fos , c jun and Egr 1 ) and fibronectin gene expressions in rat balloon injured artery , which is associated with the inhibition of neointima formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined the effects of this detergent on neurons and glia , including expression of c Myc , c Jun , JunB , and c Fos , and on immunocytes in the guinea pig ileum . ^^^ Neuronal c Myc began to disappear while c Fos , c Jun , and JunB were evident in some neuronal nuclei after 2 or 3 days . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The comparative effects of haloperidol , ( ) sulpiride , and SCH 23390 on c fos and c jun mRNA expressions , and AP 1 DNA binding activity . ^^^ The c fos and c jun mRNA expressions were measured by the RNase protection assay method following intraperitoneal injection of haloperidol , ( D 1 and D 2 receptor antagonists ) , ( ) sulpiride , ( D 2 receptor antagonist ) , and SCH 23390 , ( D 1 receptor antagonist ) . ^^^ The SCH 23390 did not induce expression of either c fos or c jun mRNA . ^^^ A significant decrease of c fos as well as c jun mRNA expression was found due to pretreatment with SCH 23390 ( 1 mg / kg i . p . ) followed by injection of ( ) sulpiride ( 20 mg / kg i . p . ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The pattern of IEG mRNA induction fell into three classes : IEGs that were induced in both damaged and spared areas ( c fos , fos B , jun B , and egr 1 ) , IEGs that were induced specifically in the damaged areas ( fra 2 and c jun ) , and an IEG that was significantly induced by saline injection and / or the cold treatment ( jun D ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of ICE and inhibition of c fos , jun D and zif 268 in 12 month old spontaneously hypertensive rats . ^^^ A semi quantitative reverse transcription polymerase chain reaction ( RT PCR ) assay was used to examine ICE , c fos , jun D and zif 268 mRNA expression in the aortic and renal artery of 12 month old SHRs and wistar rats . ^^^ In contrast , the aortic and renal artery expression of immediate early genes ( IEGs ) , c fos , jun D and zif 268 , were significant lower in SHRs than in wistar rats . ^^^ Thus , our results suggest that differential regulation of death gene ICE and IEGs such as c fos , jun D and zif 268 might be involved in the mechanism of pathogenesis of hypertension . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This TRE bound TPA induced specific nuclear complexes in vitro containing junD , c jun , c fos , and fra 2 but not cAMP responsive element binding / activating transcription factor family proteins . ^^^ Cotransfection of c jun and c fos expression vectors into SK N SH cells induced transactivation from ICAM 1 promoter constructs containing the intact but not mutated TRE site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the other hand , hypothermia during ischemia which is known to protect the CA 1 subfield against ischemic damages , led to a prolonged elevation of the activator protein 1 binding up to 9 h after the reperfusion in this vulnerable subfield at least in part through expression of c Fos protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since apoptosis is believed to be an active process involving gene expression , immunocytochemical of c Fos and c Jun transcription factor proteins was performed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We additionally demonstrate that the c Fos and delta FosB proteins expressed following QA lesion bind to the functional AP 1 site in the promoter of the nerve growth factor ( NGF ) gene , the regulation of which temporally and spatially coincides with the AP 1 protein increases in the QA lesioned striatum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results suggest that KA induced proENK and proDYN mRNA expressions may require on going synthesis of proteins , such as c Fos , c Jun and 35 kDa Fra , which may have a possible role in the up regulation of proENK and proDYN gene expression through the binding with AP 1 and ENKCRE 2 DNA binding motifs . . ^^^ The effect of cycloheximide ( CHX ) , a protein synthesis inhibitor , on the regulation of proenkephalin ( proENK ) and prodynorphin ( proDYN ) mRNA levels , proto oncogenes , such as c fos , 35 kDa fra and c jun mRNA , and the levels of their products induced by kainic acid ( KA ) in rat hippocampus was studied . ^^^ The increases of proENK and proDYN mRNA levels induced by KA were well correlated with the increases of c Fos , 35 kDa Fra and c Jun protein levels . ^^^ KA administration increased the hippocampal levels of c Fos , 35 kDa Fra and c Jun proteins with the time . ^^^ The increases of c Fos , 35 kDa Fra and c Jun protein levels induced by KA administration were also inhibited by CHX pre administration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Complex mechanisms for c fos and c jun degradation . c fos and c jun proto oncogenes have originally been found in mutated forms in murine and avian oncogenic retroviruses . ^^^ Both c jun and c fos proteins are metabolically unstable . ^^^ In vivo and in vitro work by various groups suggests that multiple proteolytic machineries , including the lysosomes , the proteasome and the ubiquitous calpains , may participate in the destruction of c fos and c jun . ^^^ It has been demonstrated that , in certain occurrences , the degradation of both c fos and c jun by the proteasome in vivo involves the ubiquitin pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine whether normal breast cells have different levels of activating protein 1 ( AP 1 ) expression and activation relative to breast cancer cells , we have compared the level of c Jun and c Fos expression and AP 1 activity in human mammary epithelial cells ( HMECs ) at different stages of transformation ( normal proliferating HMECs , immortal HMECs , oncogene transformed HMECs , and breast cancer cell lines ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of the NF kappaB / Rel family members tested , this CD28RE / AP 1 specific complex contains predominantly c Rel , despite the fact that both p 50 and RelA can efficiently bind to the CD28RE . c Fos and c Jun are also found in this CD28RE / AP 1 specific complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In light of the JNK / SAPK dependent induction of c jun and c fos transcription , and the Jun / Fos induced transcription of xenobiotic metabolizing enzymes , these data provide a potential critical role of JNK / SAPK and p 38 in the induction of a cellular defense program against cytotoxic xenobiotics such as MMS . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proto oncogenes c jun and c fos are down regulated in human endometrium during pregnancy : relationship to oestrogen receptor status . ^^^ Animal and in vitro studies have shown that proto oncogenes c fos and c jun are regulated by oestrogen receptor ( ER ) complex . ^^^ We have previously shown by Northern blot analysis that proto oncogenes c fos and c jun are strongly expressed in human proliferative and early to mid secretory endometrium . ^^^ In this study , we examined the expression of the messenger RNA ( mRNA ) of the nuclear proto oncogenes c fos and c jun in 10 early ( 6 10 weeks ) and 20 term ( 30 40 weeks ) pregnancy decidua by Northern blotting . ^^^ When using 30 mer oligonucleotide probes , hardly any signals for c fos and c jun could be identified either in early or in late pregnancy decidua . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Asbestos and the phorbol ester tumor promoter , 12 O tetradecanoylphorbol 13 acetate ( TPA ) , increase c fos and c jun mRNA levels and AP 1 DNA binding activity in rat pleural mesothelial ( RPM ) cells , a target cell of asbestos induced mesotheliomas ( N . ^^^ Inhibition of protein kinase C prevents asbestos induced c fos and c jun proto oncogene expression in mesothelial cells . ^^^ We then pretreated cells with phorbol ester dibutyrate to down modulate PKC or with calphostin C , a specific PKC inhibitor , to determine if depletion of PKC alpha could block asbestos induced c fos / c jun expression . ^^^ Quantitation of Northern blots showed that fiber associated c fos / c jun mRNA levels were significantly lower either after PKC alpha down modulation or pretreatment with calphostin C . ^^^ These inhibitors decreased crocidolite induced c fos but not c jun levels , suggesting that tyrosine kinases have different regulatory roles in asbestos induced c fos versus c jun signaling pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To this end male Sprague Dawley rats were exposed to 0 . 1 % carbon monoxide for 0 . 5 , 1 and 6 h or to 9 % oxygen for 6 h and mRNA levels for c jun , c fos , c myc and EGR 1 were assayed by RNase protection in hearts , kidneys , livers and lungs . ^^^ We found that hypoxia increased c jun mRNA levels between twofold ( lung ) and eightfold ( liver ) in all organs examined ; c fos mRNA increased between three fold ( lung ) and 20 fold ( heart ) ; c myc mRNA increased between twofold ( lung ) and sixfold ( heart ) ; and EGR 1 mRNA increased between twofold ( lung ) and sixfold ( heart ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis of c fos and c jun mRNAs from these same treatment groups revealed increased protooncogene expression in the uterus of hormone treated rats compared with the control animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , examination of the expression of the early response proto oncogenes , c fos , c jun , and c myc , after PH demonstrated down regulated induction of c jun mRNA transcripts by SMC , sustained for an eight hour period . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To shed light on the molecular mechanisms involved in the pathogenesis of uterine leiomyomas , transcript levels of the immediate early genes c fos , c myc , and c jun and of the estrogen receptor ( ER ) and progesterone receptor ( PR ) were determined in tissue samples of human myometrium and leiomyoma . ^^^ The messenger RNA ( mRNA ) content was analyzed by RT PCR . mRNAs for c fos , c myc , c jun , ER , and PR were detected in all 18 samples of leiomyoma and corresponding myometrial tissue collected in this study . ^^^ Additionally , the findings suggest that sex steroids do not influence the different expression patterns of c fos , c myc , and c jun in leiomyomas , as compared with myometrium . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ATF increased c myc , c jun , and c fos gene expression in a time dependent manner for up to 60 min , after which mRNA levels fell . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since transcription of the TGF beta 1 gene is believed to be largely governed by the activating protein 1 ( AP 1 ) complex , we also examined the expression of mRNA for c fos and c jun protoon coproteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have now found in rat aorta that carbachol , a muscarinic cholinergic agonist that promotes release of nitric oxide ( NO ) , inhibits expression of c fos and c jun mRNA induced by alpha 1 receptors . ^^^ These results suggest that NO , acting through a cGMP dependent mechanism , inhibits expression of the c fos and c jun genes in arteries , which may contribute to the growth inhibiting effects of the endothelium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
LIF significantly induced an immediate early response of genes c fos and junB 3 hr after stimulation , but not of c jun during the process of proliferation of MCF 7 and Hs 700T cells , with maximum levels at 30 60 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , there are many gaps in our knowledge , which include : ( a ) endogenous quaternary ammonium compounds other than ACh in human placental extracts ; ( b ) the specificity of placental enzymes ; ( c ) the subtypes and structures of placental muscarinic and nicotinic receptors ; and ( d ) the significance of placental alpha bungarotoxin binding proteins , ACh receptor stimulation cellular signaling by second messengers , and activation of immediate early target genes ( C fos , C jun ) encoding transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The early transcription of c fos , c jun , and c myc proto oncogenes and the increased expression of transcription factors AP 1 and AP 2 , induced by DZA and insulin , appear to be crucial events in the differentiation of the 3T3 L 1 fibroblasts to adipocytes . . ^^^ Treatment of confluent 3T3 L 1 fibroblasts with DZA or insulin produced a rapid but transient expression of mRNA for proto oncogenes c fos and c jun within 30 60 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we present evidence that RME can down regulate AP 1 activity induced by the tumor promoter 12 O tetradecanoylphorbol 13 acetate , insulin , growth factors , and the nuclear proto oncogenes c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NGFI B , c fos , and c jun mRNA expression in mouse brain after acute carbon monoxide intoxication . ^^^ The levels of NGFI B , c fos , and c jun mRNA were determined by Northern blot analysis . ^^^ A time course study in the cerebral cortex indicated that the induction of NGFI B , c fos , and c jun mRNA started as early as 15 minutes , reached a peak at 30 minutes , and returned to the basal level at 1 hour after the ACOI . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This report demonstrates that a single dose of desipramine ( 10 or 25 mg / kg ) , a classical tricyclic antidepressant drug acting on the adrenergic system , induced c fos and zif 268 expression in rat hippocampus without affecting c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We reported that repeated immobilization for six days attenuates the subsequent acute immobilization stress induced expression of the immediate early genes c fos , fos B , jun B and nerve growth factor induced gene B ( NGFI B ) , but not of NGFI A , in the rat paraventricular hypothalamic nucleus . ^^^ In control rats acute immobilization induced c fos , fos B , jun B , NGFI A and NGFI B messenger RNA in the paraventricular hypothalamic nucleus , whereas all of them except NGFI A , were significantly reduced in rats given 200 and 400 mg corticosterone implants . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phosphorylation of the guanine nucleotide exchange protein p 170 son of sevenless further suggested a receptor mediated activation of the ERK pathway . c Fos and c Jun expression , downstream targets of ERK and JNK , was dramatically increased in cultured tissue compared with uncultured tissue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the same system , the antioxidants , N acetyl cysteine ( NAC ) and pyrrolidine dithiocarbamate ( PDTC ) at concentrations shown to up regulate the mRNAs of both c jun and c fos , also enhance the transactivity of AP 1 . ^^^ Hydrogen peroxide induced expression of the proto oncogenes , c jun , c fos and c myc in rabbit lens epithelial cells . ^^^ To explore the oxidative stress response of the lens system at the gene expression level , we have examined the effects of H2O2 on the mRNA change of the proto oncogenes , c jun , c fos and c myc in a rabbit lens cell line , N / N1003A . ^^^ H2O2 treatment of the rabbit lens epithelial cells for 60 min induces quick up regulation of both c jun and c fos mRNAs . ^^^ The maximal induction is 38 fold for c jun at 150 microM and 72 fold for c fos at 250 microM H2O2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Three and 6 h after irradiation , the Fos and Jun proteins and their binding activity to an AP 1 consensus sequence were strongly induced by high doses of gamma rays . c Fos , c Jun and JunB proteins were found to be present in gel shift complexes by probing with specific antibodies . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differences in mRNA expression of endothelin 1 , c fos and c jun in placentas from normal pregnancies and pregnancies complicated with preeclampsia and / or intrauterine growth retardation . ^^^ Our aim was to compare the mRNA expression of the growth related protooncogenes c fos and c jun and the vasoconstrictor and growth factor endothelin 1 ( ET 1 ) in placentas from normal pregnancies with those of PE and IUGR . ^^^ The mRNA expression of c jun was significantly higher in all groups of complicated pregnancies while ET 1 and c fos mRNA expression was significantly higher only in the group with IUGR . ^^^ These results support the concept that an aberrant placental mRNA expression of the ET 1 , c fos and c jun genes is part of an altered pattern of gene expression in pathological pregnancies . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protooncogenes like c fos and c jun act as transcription factors for other genes and may be involved in the regulation of programmed cell death . ^^^ Whereas levels of hsp 70 were increased about two fold in all groups ( P < 0 . 05 ) , induction of c fos and c jun was most pronounced following the Hamburg cardioplegic solution ( P < 0 . 05 versus baseline and for differences to other groups ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the proto oncogenes c myc , c fos , and c jun and histone 2A decreased rapidly in the first 24 h of culture in both cell preparations , followed by an increase in expression of c fos and junB over the next 3 days of culture . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As for the expression of early response genes , 1 microM nodularin or microcystin LR induced expression of the c jun , jun B , jun D , c fos , fos B and fra 1 genes in the hepatocytes , and the expression of these genes was prolonged up to 24 h , suggesting mRNA stabilization induced by inhibition of protein phosphatases 1 and 2A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After incubation , we noted enhanced c fos and cjun genes as well as induction of p 21 protein . ^^^ An appropriate dose of HGF elevated c fos , reduced c jun and p 21 , induced G1 / S transition , and inhibited apoptosis . ^^^ Cells not treated with HGF expressed no c fos , c jun , or c myc , and remained in G0 / G1 . ^^^ Taken together , our results support the conclusion that not only c fos , cjun , and c myc , but also p 53 and p 21 are required for blast apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transfection with an expression vector for c Fos inhibited the effects of c Jun , suggesting that c Jun acts independently of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In a rat model of acute CCl 4 induced hepatic injury , we examined the expression of genes involved in cellular response to different kinds of stress , including oxidative stress ( hsp 70 family , heme oxygenase ) , in free radical detoxification ( Mn superoxide dismutase and Cu / Zn superoxide dismutase ) , in iron homeostasis ( H and L ferritin subunits ) and in the cell cycle ( c fos , c jun , histone H 3 ) . ^^^ We showed that induction of c fos and c jun protooncogenes is the earliest event after CCl 4 administration , whereas histone H 3 expression peaked at 24 48 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Kainic acid induced excitotoxicity is associated with a complex c Fos and c Jun response which does not preclude either cell death or survival . c fos and c jun mRNA induction and c Fos and c Jun protein expression were examined in the brains of adult rats subjected to systemic kainic acid ( KA ) injection at convulsant doses . ^^^ Induction of c fos and c jun mRNA , as seen with in situ hybridization , occurred in the piriform and entorhinal cortices , neocortex , amygdala , hippocampus , dentate gyrus , and discrete thalamic nuclei . ^^^ Although the regional distribution of c Fos and c Jun immunoreactive cells in the hippocampus , layer 2 of the entorhinal and piriform cortices , basal amygdala , and discrete thalamic nuclei matched the distribution of cells committed to dying , c Fos and c Jun immunoreactive cells in the neocortex and dentate gyrus survived . ^^^ Therefore , the present data show that c fos and c jun are not predictors of either cell death or survival , but rather , markers of cells sensitive to KA excitotoxicity . ^^^ These results show that c Fos and different Jun related antigens are expressed following KA excitotoxicity , and that posttranslational modifications involving phosphorylation of c Fos and Jun ( s ) may occur following KA injection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The distribution of SRF and ATF 2 suggests that their putative target genes c fos , junB , krox 24 and c jun can be independently regulated from SRF and ATF 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results of the stretching experiments demonstrate that human PDL cells respond to mechanical stretch by a signal transduction pathway which most likely includes specific small GTP binding proteins , such as Rab and Rho , as well as well defined transcription factors ( c Jun and c Fos ) . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By RT PCR analysis , ST induced apoptosis showed c fos and c jun up regulation , whereas serum withdrawal induced apoptosis showed c jun up regulation and the same levels of p21 / waf 1 and c myc . ^^^ These results indicate that ST can rapidly induce apoptosis in SAS , possibly via a c fos and c jun pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Opposing activities of c Fos and Fra 2 on AP 1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters . ^^^ This induction was dependent upon the expression of c Fos since AP 1 transcriptional activity was not increased in TPA treated keratinocytes derived from c fos null mice . ^^^ Analysis of AP 1 protein expression in calcium and TPA treated keratinocytes demonstrated that only TPA increased the expression of c Jun , while Jun B and Jun D were induced by both of these agents . c Fos was expressed only in TPA treated keratinocytes , Fra 2 was expressed only in calcium treated cells , and Fra 1 was expressed in both . ^^^ Exogenous expression of Fra 2 repressed AP 1 transcriptional activity in TPA treated keratinocytes , while c Fos expression activated the AP 1 sequence in calcium treated keratinocytes . ^^^ These data indicate that Fra 2 and c Fos play opposing roles in regulating AP 1 activity in keratinocytes and that multiple inducer dependent regulatory pathways may exist for the expression of keratinocyte differentiation markers . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The acute effect of global system for mobile communication ( GSM ) microwave exposure on the genomic response of the central nervous system was studied in rats by measuring changes in the messenger RNAs of hsp 70 , the transcription factor genes c fos and c jun and the glial structural gene GFAP using in situ hybridization histochemistry . ^^^ C jun and GFAP messenger RNAs did not increase in any of the experimental groups . 24 h after exposure , immunocytochemical analysis of FOS and JUN proteins ( c FOS , FOS B , c JUN JUN B , JUN D ) , of HSP 70 or of KROX 20 and 24 did not reveal any alterations . ^^^ C jun and GFAP messenger RNAs did not increase in any of the experimental groups . 24 h after exposure , immunocytochemical analysis of FOS and JUN proteins ( c FOS , FOS B , c JUN JUN B , JUN D ) , of HSP 70 or of KROX 20 and 24 did not reveal any alterations . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also measured the induction of c fos and c jun expression by Con A in T cells from young and old rats fed ad libitum or caloric restricted diet . ^^^ The induction of c fos protein and mRNA levels but not c jun protein or mRNA levels decreased significantly with age . ^^^ Caloric restriction significantly ( P < 0 . 05 ) reduced the age related decline in c fos expression but had no significant effect on c jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNA contents for genes associated with transcriptional activation [ c fos , c jun , JunB , nuclear respiratory factor 1 ( NRF 1 ) ] , mitochondrial proliferation [ cytochrome c ( Cyt c ) , cytochrome oxidase ] , and mitochondrial differentiation [ carnitine palmitoyltransferase 1 ( CPT 1 ) isoforms ] were measured . ^^^ The results establish a temporal pattern of mRNA induction beginning with c fos ( 0 . 25 3 hr ) and followed sequentially by c jun ( 0 . 5 3 hr ) , JunB ( 0 . 5 6 hr ) , NRF 1 ( 1 12 hr ) , Cyt c ( 12 72 hr ) , and muscle specific CPT 1 ( 48 72 hr ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoblot analysis showed that lovastatin decreased membrane bound p21ras and inhibited FCS induced c fos and c jun protein expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , expression of c fos , c jun and junB immediate early genes were followed in mouse brain after irradiation . ^^^ C fos and junB , but not c jun , mRNA was induced within 15 min in unanesthetized irradiated mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Ets transcription factors interact with each other and with the c Fos / c Jun complex via distinct protein domains in a DNA dependent and independent manner . ^^^ Recently , we found that ERG , an Ets family member , activates collagenase 1 gene but not stromelysin 1 by physically interacting with c Fos / c Jun . ^^^ We found that ETS 2 could weakly associate with in vitro synthesized ETS 1 , c Fos , and c Jun and strongly with c Fos / c Jun complex and ERG via several distinct ETS 2 domains including the C terminal region that contains the DNA binding domain . ^^^ The DNA dependent interaction of ETS 2 with c Fos / c Jun was enhanced by specific DNA fragments requiring two Ets binding sites of the stromelysin 1 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have characterized the expression of a large range of ITFs ( c Fos , Fos B , Fos related antigens , c Jun , Jun B , Jun D , Krox 20 , and Krox 24 ) using multiple antisera in AD postmortem hippocampi and compared this with human control hippocampi as well as Huntington ' s disease hippocampi and human epilepsy biopsy tissue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine if ANG 4 also modulates a mechanically induced cardiac growth response , we studied the effects of two AT 4 receptor ligands , [ Nle 1 ] ANG 4 and [ divalinal ] ANG 4 , on mechanically induced immediate early gene expression ( c fos , egr 1 , and c jun ) in the buffer perfused ( 30 degrees C ) , ejecting , isolated rabbit heart . ^^^ Mechanical load alone ( high systolic pressure and high end diastolic volume ) induced approximately 23 , 49 and 5 fold increases in c fos , egr 1 and c jun mRNA ( in comparison to control hearts ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Subarachnoid hemorrhage induces c fos , c jun and hsp 70 mRNA expression in rat brain . ^^^ The genes c fos and c jun were induced in the cerebral cortex , hippocampus and dentate gyrus in the penetrated side . mRNA coding for hsp 70 was induced in the cerebral cortex , hippocampus , thalamus , hypothalamus and caudoputamen in the penetrated side and extended to the contralateral hemisphere . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c Fos , c Jun , c Myc and Ki 67 antigen was assessed immunohistochemically . ^^^ RESULTS : c Fos and c Jun were detected 2 h after ligation and the expression of these two proteins reached a maximum after 4 h , becoming undetectable 16 h after ligation . ^^^ The expressions of c Fos and c Jun were strongly correlated ( r = 0 . 9854 , P < 0 . 001 ) . ^^^ The change in rER was also significantly correlated with the expression of c Fos and c Jun within 8 h after ligation . ^^^ CONCLUSION : The expression of c Fos and c Jun , but not c Myc , might contribute to the hypertrophy of the ureteric smooth muscle layer during the course of complete ureteric obstruction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore the mRNA levels of c fos and c jun by PAF in WT H cells were much lower than those in D H cells . ^^^ Propranolol and butanol at concentrations that inhibited the formation of DG suppressed the PAF induced mRNA expression of c fos and c jun . ^^^ Furthermore the results obtained here suggest that sustained PLD activation in turn leads to chronic activation and membrane translocation of PKCalpha , which might play an important role in the expression of c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since proto oncogenes play a central role in the regulation of cellular growth and differentiation , localization of MYC , FOS , and JUN proteins has been studied in the testis of the lizard , Podarcis s . sicula , during the annual reproductive cycle by immunocytochemistry using antisera against c myc , c fos , and c jun products . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our data demonstrate that NO . generated by spermine 1 , 3 propanediamine N 14 [ 1 ( 3 aminopropyl ) 2 hydroxy 2 nitrosohydrazino ] butyl ] or S nitroso N acetylpenicillamine as well as H2O2 cause increased c fos and c jun mRNA levels , nuclear proteins , and complexes binding the activator protein 1 recognition sequence in RLE cells . ^^^ Differential induction of c fos , c jun , and apoptosis in lung epithelial cells exposed to ROS or RNS . ^^^ Our focus was on c fos and c jun protooncogenes , as these genes play an important role in proliferation or apoptosis , possible end points of exposure to reactive metabolites in lung . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transient transfection experiments indicated that whereas overexpression of PI 3 kinase may be sufficient to induce AP 1 and increase nuclear c Fos protein levels , PI 3 kinase may need to cooperate with other IL 1 inducible signals to fully activate NFkappaB dependent gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cAMP induced NF kappaB complex contained p 50 and RelB ; in co transfection assays , p 50 and RelB transactivated a reporter construct containing the c myb intronic NF kappaB site upstream of a minimal promoter . 8 Br cAMP and forskolin also increased the DNA binding activity of AP 1 complexes containing JunB , JunD and c Fos in MEL cells which could cooperate with NF kappaB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because the level of the transcription factor activator protein 1 ( AP 1 ) has been shown to be critical for the responsiveness of JB 6 cells to TPA induced transformation , we compared c jun and c fos expression as well as the AP 1 binding activity and the AP 1 mediated transactivation of the reporter construct TRE CAT between bcl 2 expressing cells and control cells . ^^^ When compared with control cells , bcl 2 transfected cells expressed significantly more c fos but not c jun after TPA treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to evaluate the effect of caffeine on striatopallidal neurons we used in situ hybridization to examine the mRNA expression of the immediate early genes ( IEGs ) , c fos , fos B , c jun , jun B , NGFI A and NGFI B in globus pallidus in rats given single or repeated administration of caffeine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TNFa increased c Jun protein , but only weakly induced FOS proteins ( c Fos , FosB , Fra 1 , and Fra 2 ) whereas cAMP increased the abundance of several FOS proteins ( c Fos , FosB , Fra 1 , and Fra 2 ) , with little effect on c Jun levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further studies on the effect of Hsps on recombinant Fos / Jun protein binding activity indicated that the mechanism of action involves a selective attenuation of high affinity c Fos : c Jun binding as compared with c Jun homodimer binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo , inducing c myc , c fos , c jun and p 53 genes and accumulation of sphingosine , a toxic product of the sphingomyelin cycle . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These data show that discrete populations of preoptic / hypothalamic neurons express c fos and / or jun in response to GR activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These actions were concurrent with an increase in the mRNA levels of c fos and c jun , as well as the protein levels of c Fos , c Jun , and phosphorylated CRE binding protein ( p CREB ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The products of c fos and c jun , proteins FOS and JUN , that act in conjunction forming the regulatory factor AP 1 , were detected 1 hr after stimulation in virtually all cells , using flow cytometry . ^^^ Interferon gamma induces the expression of immediate early genes c fos and c jun in astrocytes . ^^^ The expression of the proto oncogenes , c fos and c jun , in cultured mouse astrocytes and its induction by the potent astrocyte activator interferon gamma ( IFN gamma ) , were examined by Northern blot and flow cytometry . ^^^ Cycloheximide superinduced c fos and c jun induction by IFN gamma , thus indicating that both act as immediate early genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among other IEGs examined , the expression of NGFI A and junB are similar to c fos , but of lesser magnitude , whereas c jun appears to be invariant in the rat but is increased during the active phase in squirrels . ^^^ Among other IEGs , junB and NGFI A again were similar to c fos while c jun and junD were more constant . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of hypoxia ischemia on expression of c Fos , c Jun and Hsp 70 in the young rat hippocampus . ^^^ The expression of c Fos , c Jun and Hsp 70 was examined in the hippocampus at 6 , 12 , 24 , 48 , 72 h , 4 , 7 and 42 days following a combination of unilateral common carotid artery ligation and 60 min of systemic hypoxia ( 8 % oxygen , 92 % nitrogen ) in 25 day old male rats . ^^^ Immunohistochemical analysis revealed no c Fos , c Jun or Hsp 70 immunoreactivity ( IR ) in any control animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We hypothesized that the existence of a c Fos responsive element ( AP 1 site ) within the POMC gene sequence might reflect the ability of POMC neurons to express c fos proto oncogene during circadian increase of their neuronal activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos , c jun and cyclin D 1 , which are downstream of ERK in the mitogenic pathway were stimulated by thrombin but this stimulation was not affected by ceramide or dihydroceramide . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
But the transcriptional expression of c fos , c myc , c jun , H ras , 5 erb B oncogenes and Rb antioncogene in atherosclerotic lesion has not yet been reported . ^^^ The results showed that the atherosclerotic plaques contained 3 4 fold more 5 sis , c fos and c myc mRNA ( P < 0 . 01 ) , 2 fold more c jun and H ras mRNA ( P < 0 . 01 ) , and less Rb mRNA ( P < 0 . 05 ) than those in the normal aortic arteries . ^^^ These results indicate that the abnormal expression of 5 sis , c myc , c fos , c jun , and H ras oncogenes and Rb antioncogene may play an important role in arterial SMC proliferation and pathogenesis of atherosclerosis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several known bone associated proteins contain DNA binding sites in their promoter regions that recognize c fos in conjunction with c jun ( AP 1 sites ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
SB 203580 , an inhibitor of p38 / RK , has been used to analyse the role of this kinase in the induction of five IE genes ( c fos , fosB , c jun , junB and junD ) under diverse conditions of stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : A 23187 repressed androgen upregulated mRNAs for prostate specific antigen ( PSA ) and hKLK 2 , and rapidly induced mRNA levels for c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In both cell types , activation of AP 1 DNA binding activity by EGF was accompanied by the recruitment of Fra 1 into AP 1 , detected earlier in 7777 cells than in hepatocytes , and with the transient appearance of c Fos in 7777 cells only . ^^^ EGF treatment triggered almost identical programs of fos and jun gene activation at the messenger RNA ( mRNA ) level in both cell types , with an early accumulation of c fos , c jun , and junB mRNAs , but no change in junD mRNA levels . ^^^ In both cell types , c Fos and Fra 1 proteins increased after EGF treatment , but differences in the induction of Jun proteins were noted , with an increase of c Jun in hepatocytes and an increase of JunB in 7777 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the immediate early genes , c fos , c jun , and c myc : a comparison in rats of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens . ^^^ The involvement of the immediate early ( IE ) genes c fos , c jun , and c myc in regenerative liver hyperplasia is accepted , but their involvement in direct hyperplasia is uncertain . ^^^ The ability of 1 , 4 dichlorobenzene ( DCB ) ( 300 mg / kg ) ( a noncarcinogenic rat liver mitogen ) , diethylhexyl phthalate ( DEHP ) ( 950 mg / kg ) , and chlorendic acid ( 120 mg / kg ) ( both nongenotoxic hepatocarcinogens ) to induce c fos , c jun , and c myc expression in rat liver was determined by Northern blot analysis and by in situ hybridization . ^^^ Interestingly , there was a good correlation ( r 2 > or = 0 . 85 ) between c myc expression and LI , but not between LI and c fos or c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
During the `` central sensitization ' ' phenomenon , noxious stimuli lead to expression of IEGs ( c fos , c jun , krox 24 ) ; their proteic products have been postulated to convert short term stimulations into long lasting responses in dorsal horn neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoresis mobility shift assays were performed to link c Fos and c Jun ( ie , components of the heterodimeric transcription factor AP 1 ) and ANP induction . ^^^ Antibodies directed against c Fos protein resulted in a shift of this DNA / protein complex , suggesting physical interaction between AP 1 and the ANP promoter . ^^^ However , the transient nature of c fos and c jun upregulation also suggests that AP 1 is not the only mediator of ANP induction in LV hypertrophy . . ^^^ Northern and Western blots revealed that elevated wall stress induced LV c fos and c jun mRNAs ( 3 . 5 and 3 fold , P < . 05 after 60 minutes ) , c Fos and c Jun proteins ( 3 . 9 and 4 . 3 fold , P < . 05 after 120 minutes ) , as well as ANP mRNA ( 2 . 2 fold , P < . 05 after 120 minutes ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Kinase activation is followed by an increase in c fos and c jun gene expression and enhanced activator protein 1 ( AP 1 ) DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several genes are involved in regulation of cell survival and apoptosis : bcl 2 / bax , p 53 , c myc and transcription factors such as cdk , c myc , c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Changes on a molecular level in peripheral tissue as well as in the central nervous system induce `` cellular early genes ' ' , a synthesis of c fos , c jun and other proteins favouring the chronification of pain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined the expression of c jun , c fos and jun B mRNA levels in cultures of different melanocytic cell types to determine if biologic differences among these cells was due to their level of proto oncogene expression . ^^^ Because cell growth and differentiation are also known to be affected by serum conditions , the expression of c jun , c fos and jun B was examined under normal serum conditions and serum starved and repleted conditions which stimulates proto oncogene expression . ^^^ Expression of c jun and jun B was not significantly different among the cell types studied under normal serum conditions , or serum starved and refed conditions and c fos was not detectable in any of the unstimulated cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is proposed that they exert tumor promoting activity by transcriptional regulation of nuclear proto oncogenes , such as c fos , c jun , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Angiotensin 2 stimulates activation of Fos regulating kinase and c Jun NH 2 terminal kinase in neuronal cultures from rat brain . c Fos / c Jun dimers ( activating protein 1 transcription factor ) are involved in the modulatory actions of angiotensin 2 ( Ang 2 ) on brain norepinephrine neurons , effects mediated via Ang 2 type 1 ( AT 1 ) receptors . ^^^ The transcriptional activities of c Fos and c Jun can be augmented by Fos regulating kinase ( FRK ) and c Jun NH 2 terminal kinase ( JNK ) , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos is potentially capable of complexing with members of the c jun family to become the AP 1 transcription complex . ^^^ Parallel to c fos expression , we found that only with the HLA B 27 transfectant was there expression of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of c jun is exerted through interactions with c fos at the AP 1 motifs in the target promoters , whereas both junB and junD act independently of the binding at the AP 1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cellular distribution of c Jun and c Fos in rat lung before and after bleomycin induced injury . ^^^ C Jun and c Fos transcription factors have been associated with enhanced cellular proliferation . ^^^ In normal rat lung , c Jun and c Fos are present in alveolar macrophages and type 2 pneumocytes , in the bronchiolar epithelium and in smooth muscle cells of bronchioli and blood vessels . ^^^ Subcellular fractionation of proteins revealed a predominant presence of both c Jun and c Fos in the heavy membrane fraction containing mitochondria and secretory granules . ^^^ This was confirmed by immunoelectron microscopy , which also revealed a different localization of c Jun and c Fos in different cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive expression c fos , c jun , and NF kappa B mRNA is in nucleated fetal blood cells and up regulation of c fos and c jun with anti CD 3 stimulation . ^^^ We used reverse transcriptase polymerase chain reaction to examine both fetal and term neonatal cord bloods for mRNA expression of three transcription factors implicated in T cell activation : c jun , c fos , and NF kappa B ( p 50 subunit ) . ^^^ Activation of term infant cord blood mononuclear cells with anti CD 3 monoclonal antibodies resulted in up regulation of both c jun and c fos mRNAs within 15 min of stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of three of the immediate early genes examined , c fos , NGFI A and jun B , was transiently increased in the ipsilateral dorsal horn of the spinal cord following the partial ligation of the sciatic nerve . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mesoderm induction by heterodimeric AP 1 ( c Jun and c Fos ) and its involvement in mesoderm formation through the embryonic fibroblast growth factor / Xbra autocatalytic loop during the early development of Xenopus embryos . ^^^ Ectopic overexpression of two components of AP 1 ( c jun and c fos together , but not alone ) produced posteriorized embryos and induced mesoderm formation in animal cap explants , indicating that both AP 1 heterodimers are required for mesoderm induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Restraint led to a rapid transient increase in c fos but not c jun expression in hypothalamus and pituitary . ^^^ Changes in jun B expression in hypothalamus were qualitatively similar to c fos , though not statistically significant at 30 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IMO stress induces rapid expression of c fos , c jun and NGFI A mRNAs in the heart and stomach . ^^^ We further show that prior exposure to IMO stress for 6 days , or implantation of corticosterone pellets suppresses the induction of c fos , fos B , jun B and NGFI B , but not that of NGFI A in the rat PVH . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , at the lower concentration of 1 nM , it induced c fos and c jun expression in both cultured myocytes and nonmyocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Crocidolite asbestos fibers have been reported to induce sustained expression of the c fos and c jun protooncogenes in rat pleural mesothelial cells in vitro ( Heintz et al , Proc . ^^^ Two of the cell lines derived from highly invasive murine mesotheliomas overexpressed c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In experiment 2 , the effect of 24R , 25 ( OH ) 2vitamin D 3 on the alterations in c fos , c myc and c jun oncogene expression in response to DMH administration was examined by northern blot analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Alterations in possible trans acting factors were examined to clarify the mechanism of repression by UV irradiation . c Jun mRNA was induced 3 . 5 fold at 4 h after irradiation , but by 24 h fell to a lower level than that observed initially . c Fos mRNA was increased 10 fold at 1 h but was completely suppressed at 12 and 24 h . ^^^ Thus , the changes of c Jun and c Fos mRNA differed from that of GST P mRNA . ^^^ Although basal expression of the GST P gene was mainly dependent on GPE 1 , altered expression of c jun , c fos and other genes coding for factors possibly trans acting on GPE 1 did not appear to be responsible for the decreased GST P mRNA levels . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Serum or platelet derived growth factor addition to serum deprived mutant PKR expressing cells induced transcription of the early response genes c fos and c jun , indicating that the immediate early response signaling was intact . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Similar experiments were also performed with respect to expression of the nuclear proto oncogenes , c fos and c jun , in MG 63 cells . ^^^ Both dexamethasone and calcitriol rapidly but transiently increased the expression of the c fos and c jun proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the transcription factors c Jun and JunB , but not c Fos , was induced in SFFV infected cells in the absence of Epo , suggesting that constitutive activation of the Raf 1 / MAP kinase pathway by the virus may result in deregulation of AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of p 202 in transfected cells retards cell proliferation . p 202 modulates the pattern of gene expression by inhibiting the activity of various transcription factors including NF kappaB , c Fos , c Jun , E2F 1 , and p 53 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of inducible transcription factors was studied following repetitive electroconvulsive seizures ( ECS ) , c Fos , c Jun , JunB , and JunD immunoreactivities were investigated following a single ( 1 10 ECS ) or repetitive ECS evoked once per day for 4 , 5 , or 10 days ( 4 10 ECS , 5 10 ECS , or 10 10 ECS ) . ^^^ In a second model of systemic excitation of the brain , repetitive daily injection of kainic acid for 4 days completely failed to express c Fos , c Jun , and JunB after the last application whereas injection of kainic acid once per week did not alter the strong expressions compared to a single application of kainic acid . ^^^ Infusion of BDNF completely reinduced c Fos expression during 5 10 ECS or 10 10 ECS in the cortex ipsilaterally to the cannula and , to a less extent , also increased the expression of c Jun and JunB when compared to saline treated controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^ Both c fos and c jun mRNAs were coinduced in muscle fiber nuclei . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Parallel experiments have confirmed previous studies showing increases in c Fos expression and AP 1 DNA binding activity following metyrapone treatment but we have shown that c Fos associated binding activity does not appear to contribute to the increase in activity detected using the CRE binding probe . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemical studies using antibodies to myogenic regulatory factors ( MRFs ) Myo D , myogenin , myf 5 , and myf 6 , and transcription factors c Fos and c Jun , were performed on muscle biopsies from patients suffering from Duchenne and Becker muscular dystrophies , polymyositis , and denervation atrophy , to investigate whether expression of these factors occurs during degeneration and regeneration of adult muscle fibres . ^^^ Increased Myo D , myogenin , myf 5 and myf 6 immunoreactivity was not observed in the nuclei of denervated muscle fibres , although strong c Fos and c Jun immunoreactivity was seen in the nuclei of denervated muscle fibres ; this suggests that denervation triggers the expression of these transcription factors . ^^^ Taken together , these observations demonstrate that MRFs and c Fos and c Jun are selectively expressed in different human muscular disorders . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Morphine at concentrations of 10 ( 12 ) M to 10 ( 10 ) M also modulated mRNA expression of early growth related genes ( c fos , c jun and c myc ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cell death caused by human amylin was determined to be predominantly of an apoptotic nature , with a possibility of a portion of necrotic cell death , which was not accompanied by increased expression of c Jun or c Fos inducible transcription factors . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of human dermal fibroblasts with IGF 1 caused a substantial increase in c fos and c jun mRNA expression within 30 and 60 min , respectively . ^^^ In contrast to c jun mRNA which was constitutively expressed by dermal fibroblasts , the expression of c fos mRNA was transient and only detectable between 15 and 60 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Feeding of AAF ( 0 . 02 % ) for 3 months elevated the levels of c Fos , c Jun and c Myc proteins in the rat livers . ^^^ The AAF induced c Jun , c Fos and c Myc expressions were significantly magnified ( P < 0 . 001 ) by NaNO 2 . ^^^ These data confirmed that the strengthening of AAF induced hepatocarcinogenesis by NaNO 2 should be associated with its enhancing effect on the AAF induced increases in the expressions of c Jun , c Fos and c Myc . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Indeed , GnRH activates the expression of both c jun and c fos which might participate in gene regulation via the formation of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel mobility shift and supershift assays revealed that TPA treatment of HepG 2 results in increased binding activity of the AP 1 proteins , c Jun , JunD , and c Fos , to both sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of immediate early genes of the c fos and c jun families , whose transcription and activation are regulated by MAP kinases , is differentially induced by insulin and TPA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since c Fos / c Jun ( activating protein 1 ( AP 1 ) ) are expressed in vascular endothelium during proinflammatory conditions , we investigated the role of AP 1 proteins in the expression of VCAM 1 by TNF alpha in SV 40 immortalized human microvascular endothelial cells ( HMEC ) . ^^^ The ability of TNF alpha to activate the kappaB motif ( kappaL kappaR ) dependent VCAM 1 promoter chloramphenicol acetyltransferase ( CAT ) reporter gene lacking a consensus AP 1 element was markedly inhibited by co transfection of the expression vector encoding c fos ribozyme , which decreases the level of c fos by degrading c fos mRNA , or c fos or c jun oligonucleotides . ^^^ TNF alpha induced expression of both early protooncogenes , c fos and c jun . ^^^ Conversely , co transfection of c Fos and c Jun encoding expression vectors potentiated the p65 / NF kappaB mediated transactivation of the VCAM 1 promoter CAT reporter gene . ^^^ In gel mobility supershift assays , the antibodies to c Fos or c Jun inhibited the binding of TNF alpha activated nuclear NF kappaB to the kappaL kappaR , suggesting that both c Fos and c Jun interacted with NF kappaB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , studies using c fos knockout mice have established a unique role for Fos , as a member of the AP 1 transcription factor complex , in determining the differentiation and activity of progenitors of the osteoclast lineage , a population of bone forming cells which are of hematopoietic origin as well . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CREB repressed while c Fos and c Jun activated transcription through the DYNCRE 3 site in transient co transfections in PC 12 cells . ^^^ We propose a model in which inflammation induced phosphorylation of CREB relieves CREB repression at the DYNCRE 3 site , P CREB binds to the c Fos promoter , and Fos / Fra , P CREB , and P c Jun interact at the DYNCRE 3 site to activate prodynorphin gene transcription . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the other hand , c fos mRNA expression induced by complement was inhibited only 50 % by PD 098 , 059 , while the c jun mRNA level was not affected by this MEK 1 inhibitor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Estrogens transiently induce a number of nuclear protooncogenes , such as c fos and c jun family proteins , which act as transcription factors through estrogen receptor ( ER ) system in the endometrial epithelium of mature and immature rodents . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oncostatin M stimulates c Fos to bind a transcriptionally responsive AP 1 element within the tissue inhibitor of metalloproteinase 1 promoter . ^^^ Fos and Jun nuclear factors bound constitutively to this site as identified by supershift analysis in electrophoretic mobility shift assays , and oncostatin M ( but not IL 6 ) induced an additional `` complex 2 ' ' that contained c Fos and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , cells expressing a deletion mutant of MEN lacking the lysine rich region did not exhibit such biological abilities . c Fos protein expression and AP 1 activity were elevated in the MEN expressing cells , which might be part of the mechanism responsible for the transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Therefore , we studied the involvement of iron and ROS in the modulation of Jun N terminal kinase 2 ( JNK 2 ) activity , c jun and c fos mRNA levels , key signaling steps in the transcriptional control of matrix degrading metalloprotease ( MMP ) 1 / interstitial collagenase and MMP 3 / stromelysin 1 after UVB irradiation of human dermal fibroblasts in vitro . ^^^ The iron driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15 fold increase in JNK 2 activity , a 3 . 5 fold increase in c jun , to a 6 fold increase in MMP 1 , and a 3 . 8 fold increase in MMP 3 mRNA levels , while virtually no alteration of c fos mRNA levels were observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We therefore tested whether local administration of the neuroprotective cytokine fibroblast growth factor type 2 in vivo has an effect on the axotomy induced nuclear expression patterns of the activator protein 1 transcription factors c Fos and JunB , or c Jun in the spinal cord intermedolateral nucleus adrenal axis lesion paradigm in the rat . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of the AP 1 transcription factor c fos can circumvent this requirement via interaction with the cAMP responsive element ( CRE ) in the cyclin A promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Influences of 50 Hz magnetic fields and ionizing radiation on c jun and c fos oncoproteins . ^^^ The effect of magnetic fields ( 50 Hz , 100 microT [ rms ] sinusoidal magnetic field combined with a 55 microT geomagnetic like field ) and / or gamma rays of 60 Cobalt on the expression of the c jun and c fos proteins was investigated in primary rat tracheal epithelial cells and two related immortalized cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Balloon injury induced neointima formation in the rat carotid artery was prevented by the AT 1 receptor antagonist , which was associated with the inhibition of the induction of proto oncogenes such as c fos , c jun and Egr 1 and of increased fibronectin gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition the expression of members of the fos ( c fos ) and jun ( c jun , jun D ) gene family encoding transcription factors of the AP 1 complex was altered in all drug resistant sublines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both were activated by the c Fos and c Jun components of AP 1 , but not by Fra 1 . ^^^ In contrast , the K 6 promoter was very strongly activated by all AP 1 proteins , especially by the c Fos + c Jun and Fra 1 + c Jun combinations . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PKD 1 induced transcription is specific for AP 1 ; promoter constructs containing cAMP response element binding protein , c Fos , c Myc , or NFkappaB binding sites are unaffected by PKD 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In CNTF stimulated NBFL cells that constitutively express the SHP 2 interfering mutant , there was increased and prolonged formation of STAT / DNA complexes , but decreased AP 1 binding activity , that mirrored a down regulation of c fos expression both at the mRNA and protein level . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When these GR mutants were expressed in chicken embryonic fibroblasts by retroviral vectors , they translocated into the nucleus without addition of glucocorticoid to the culture medium , and they suppressed cellular transformation caused by 5 src and c Ha ras , as well as by c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have also demonstrated that the expression of this Ets 2 mutant is capable of interrupting the CSF 1R regulated intracellular signaling pathways by inhibiting CSF 1 induced c myc , c fos , and c jun expression in BT 20 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of C . parasitica with low levels of the protein synthesis inhibitor cycloheximide caused cpc 1 transcript levels to undergo a rapid , transient increase similar to that reported for the mammalian b ZIP transactivators , c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun mRNA expression by basic fibroblast growth factor in cultured rat Mller cells . ^^^ To elucidate the mechanism that links exogenous bFGF to transcriptional regulation of bFGF gene expression in these cells , the authors examined mRNA expression of the proto oncogenes c fos and c jun in response to exogenous bFGF in cultured rat Mller cells . ^^^ Northern blot analysis was performed to determine the mRNA expression of c fos , c jun , and bFGF . ^^^ RESULTS : Addition of bFGF to culture medium induced c fos and c jun mRNA expression in a dose and time dependent manner . ^^^ The temporal pattern of c jun gene expression was similar to that of c fos , whereas a maximum induction of c jun mRNA ( 8 . 2 fold ) was seen after 45 minutes of treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Elevated c Jun , in association with constitutively expressed c Fos , formed increased levels of transcription factor activator protein ( AP ) 1 , which is required for transcription of matrix metalloproteinases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DHEA alone , whatever the concentration used , or LPS alone at 0 . 2 ng / ml did not induce the activation of mitogen activated protein kinases ( MAPkinases ) and protein kinase C ( PKC ) or the expression of c fos and c jun . ^^^ However DHEA ( 10 [ 9 ] M or 10 [ 12 ] M ) and 0 . 2 ng / ml LPS together induced the activation of both MAPKinases and PKC and the expression of c fos and c jun . ^^^ Furthermore , the activation of PKC and MAPKinases and the expression of c fos and c jun were much greater when human monocytes were activated by both LPS ( 1 microg / ml ) and DHEA ( 10 [ 9 ] M or 10 [ 12 ] M ) than when the monocytes were activated only by LPS at 1 microg / ml . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of human gingival fibroblasts with IL 1 activated extracellular signal regulated kinases ( ERK ) , c Jun N terminal kinase ( JNK ) , and p 38 kinase activity and induced c fos expression in a dose and time dependent fashion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All trans retinoic acid ( t RA ) inhibited Jun N terminal kinase ( JNK ) and , to a lesser extent , extracellular signal regulated kinase activity in normal HBE cells . t RA reduced c fos mRNA and protein levels by decreasing c fos gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We studied the time course of expression of the inducible transcription factors ( ITF ) c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 , induced by a single intracerebroventricular injection of angiotensin 2 , in the subfornical organ ( SFO ) , median preoptic nucleus ( MnPO ) paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . c Fos and Krox 24 were expressed rapidly in neurons of all four areas but completely disappeared after 4 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel retardation electrophoresis was employed for determination of DNA binding activity of the transcription factor activator protein 1 ( AP 1 ) , which is a dimer between c Fos and c Jun protein families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Synergistic increase in c fos expression by simultaneous activation of the ras / raf / map kinase and protein kinase A signaling pathways is mediated by the c fos AP 1 and SRE sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This AP 1 binding increase involves c Jun , but not c Fos , as shown by gel supershift , Northern hybridization , and Western blotting analyses . c Jun mRNA levels are elevated by 9 hours after and remain so until at least 24 hours after exposure to LDL . c Jun protein levels increase at 12 hours and continue to rise for 24 hours after exposure to LDL . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , expression of the immediate early genes c fos and c jun was up regulated by TPA only in LNCaP and DU 145 cells , whereas PC 3 cells failed to express c fos mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of ICER in cultured spinal cord neurons results in the repression of the c fos and c jun promoters induced by forskolin and glutamate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c Jun , JunB , JunD , c Fos and ATF 2 transcription factors was studied in L4 / L5 dorsal root ganglion neurons of adult rats , in order to determine the extent to know to which extend the expression of transcription factors in vitro parallels the pathophysiological expression in vivo . ^^^ Incubation with brain derived neurotrophic factor for 15 days reduced JunB expression and raised c Fos expression , but did not affect c Jun or JunD labelings . ^^^ As with culture , incubation of explanted dorsal root ganglia with brain derived neurotrophic factor prevented the initial rise in JunB , accelerated and enhanced c Fos expression , but did not alter c Jun and JunD expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This was associated with the expression of c fos , c jun , and c myc , which , with different time courses , were induced in astrocytes after Ca2+ deprivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation with carbachol induced expression of c fos , fosB , c jun , junB , and junD . ^^^ Inhibition of protein kinase C with GF109203X suppressed the carbachol stimulated increase in mRNA levels of c fos , fosB , and junB by approximately 70 % but had only minor effects on the expression of c jun and junD . ^^^ On the other hand , preincubation with KN 62 attenuated the carbachol induced increase in c jun and junD expression by 70 % but had no effect on c fos , fosB , and junB mRNA levels . ^^^ Simultaneous inhibition of both protein kinase C and Ca2+ / calmodulin dependent kinase 2 completely abolished the carbachol stimulated expression of c jun and junD , but c fos , fosB , and junB were still expressed to a certain extent under this condition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with these findings , combined EE + DES treatment for 5 . 0 months reduced hamster kidney c myc , c fos and c jun RNA expression to 43 , 37 and 52 % , respectively , compared with levels observed after DES treatment alone . ^^^ Interestingly , TAM + DES treatment for the same period also resulted in the same low level of RNA expression of these proto oncogenes . c MYC , c FOS and c JUN protein products were comparably reduced after either EE + DES or TAM + DES treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cell death caused by LY 294002 resembles death caused by NGF deprivation in that it is blocked by a caspase inhibitor or a cAMP analog and that it is accompanied by the induction of c jun , c fos , and cyclin D 1 mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dynamics of structural changes in the chromatin of rat liver cells were studied during activation of the c myc , c fos , and c jun protooncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Anisomycin desensitization of a panel of IE genes ( c fos , fosB , c jun , junB , and junD ) , using epidermal growth factor ( EGF ) , basic fibroblast growth factor , ( bFGF ) , tumor necrosis factor alpha ( TNF alpha ) , anisomycin , tetradecanoyl phorbol acetate ( TPA ) , and UV radiation as secondary stimuli , was found to be extremely specific both with respect to the secondary stimuli and at the level of individual genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Testicular leukemia inhibitory factor ( LIF ) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription ( STAT ) 3 and STAT 1 and induce c fos transcription and activator protein 1 activation in rat Sertoli but not germ cells . ^^^ In addition , we characterized the effects of LIF on the signal transducers and activators of transcription ( STAT ) 3 and STAT 1 , c fos gene expression , and activator protein 1 regulation in primary rat Sertoli cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment with HNE resulted in activation of extracellular signal regulated protein kinases ERK 1 and ERK 2 , induction of c fos and c jun protein expression , and an increase in transcription factor AP 1 DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Repression of c fos and c jun gene expression is not part of AT 2 receptor coupled signal transduction . ^^^ Stimulation of angiotensin AT 2 receptors in the rat pheochromocytoma cell line PC 12 W following pretreatment with growth factors was able to counteract growth factor induced proliferation but not to repress growth factor induced c fos and c jun expression ; neither did AT 2 receptor stimulation cause an induction of c fos expression . ^^^ We conclude that , in contrast to other growth inhibiting agents , the antiproliferative effect of angiotensin 2 via the AT 2 receptor is not mediated by repression of the immediate early genes c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Downstream effector molecules of p21Ras include Raf 1 kinase which mediates external signals via kinase signaling pathways to nuclear transcription factors including c Fos and c Jun . ^^^ The same was true with respect to the levels of c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found a rapid induction of c fos , c jun and junB at the mRNA level after about 30 min of EGF treatment and a more delayed upregulation of fosB and fra 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoblot analyses were performed on extracts of term myometrial tissue from women receiving elective or indicated cesarean sections to test for an association between the up regulation of cx 43 expression and the up regulation of expression of the transcription factors c Jun , c Fos , and Sp 1 , which have cognate binding elements in the cx 43 5 ' flanking promoter . ^^^ Treatment of primary myometrial cultures containing ER with estrogen for 3 or 48 h did not result in up regulation of c Jun or c Fos proteins or in trans activation from the proximal cx 43 promoter with the activating protein 1 element . ^^^ Although c Fos and Sp 1 proteins could be detected by immunoblot in myometrial tissue from nonpregnant women , c Jun and Cx 43 proteins could not . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , by using electrophoretic mobility shift assays and antibody supershift analysis , we propose that c Fos , c Jun , and JunD may play major roles in the collagenase 3 activation by TGF beta 1 in human fibroblasts . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Noradrenaline increased the mRNA levels of c fos and c jun in rat 1 fibroblast lines stably expressing the cloned alpha 1 adrenoceptor subtypes . ^^^ The efficacy to induce the expression of c fos mRNA was similar for the three cell lines ( alpha1d = alpha1b = alpha1a ) but different for c jun ( alpha1a > or = alpha1b > alpha1d ) . ^^^ The EC 50 values were also different : approximately 5 nM ( c fos ) and approximately 300 nM ( c jun ) for cells transfected with the alpha1a subtype , approximately 30 nM ( c fos ) and approximately 300 nM ( c jun ) for cells transfected with the alpha1b subtype and approximately 300 nM ( c fos and c jun ) for those transfected with the alpha1d subtype . ^^^ Endothelin 1 ( 10 nM ) also increased the levels of c fos and c jun mRNAs . ^^^ It is concluded that activation of any of the three cloned subtypes can increase the levels of c fos and c jun mRNAs and that protein kinase C plays a major role in mediating such effects . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of c Fos , c Jun , osteoblast specific factor 2 , and core binding factor beta increased the response to parathyroid hormone of the wild type ( 148 ) promoter but not with mutation of either or both the activator protein 1 and runt domain binding sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of phorbol 12 myristate 13 acetate ( PMA ) on the regulation of proenkephalin ( proENK ) mRNA level , ENKCRE 2 or AP 1 DNA binding activity , and the mRNA and protein levels of proto oncogenes ( c fos , fra 1 , and c jun ) in primary cultured rat astrocytes were studied . ^^^ The results suggest that newly synthesized AP 1 proteins , such as c Fos , Fra 1 , and c Jun may play important roles in the regulation of PMA induced proENK gene expression in cultured rat astrocytes . ^^^ In addition , PMA caused the induction of c fos , c jun and fra 1 mRNA level and , especially , PMA induced increase of fra 1 mRNA level was further enhanced by CHX treatment at 4 h . ^^^ Furthermore , western immunoblot assay showed that PMA caused induction of c Fos , Fra 1 , and c Jun protein levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of ROS 17 / 2 . 8 cells with 1 , 25 ( OH ) 2D3 , however , resulted in an increase in AP 1 binding activity ; however , no significant changes in c jun and c fos levels were observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have found that MAPK and JNK activities , c jun and c fos mRNA levels and AP 1 binding activity are notably increased when cells are incubated with both EGF and PDB , PDB does not stimulate growth of fetal hepatocytes , measured either as [ 3H ] thymidine incorporation into DNA or by cell cycle analysis using flow cytometry . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest that the 6 TG sensitive protein kinase ( s ) dependent signaling pathway may be involved in the apoptotic response of HepG 2 cells exposed to hypoxia by increasing the level of c jun and c fos and the activity of AP 1 and / or by activating ICE family protease ( s ) . . ^^^ Hypoxia induced apoptosis was associated with a marked induction of c jun and c fos messenger RNAs . ^^^ Moreover , the inductive effect of hypoxia on c jun expression was also inhibited by 6 TG , whereas the levels of c fos mRNA and its protein were rather strongly increased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The stress may induce a remarkable increase in expression of c fos , c jun and c myc mRNAs in both fundic and pyloric regions of the glandular stomach . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The overexpression of 5 Rel , c Rel , and c Rel delta resulted in a prolonged elevation of c fos and c jun expression and in a sustained repression of fra 2 at both the mRNA and protein levels in fibroblasts and lymphoid cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PDGF induced activation of c Src is blocked , as is the induction of c Myc and c Fos , while tyrosine phosphorylation of the PDGFbeta receptor , PLCgamma 1 and induction of c Jun are intact . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Value of glutathione S transferase pi and the oncogene products c Jun , c Fos , c H Ras , and c Myc as a prognostic indicator in endometrial carcinomas . ^^^ OBJECTIVE : To examine the relationship between the expressions of glutathione S transferase pi ( GST pi ) and four oncogene products , c Jun , c Fos , c H Ras , and c Myc , and clinicopathological prognostic factors and patients ' prognosis in endometrial carcinomas , and to assess their prognostic value in endometrial carcinomas . ^^^ RESULTS : The overall positive rates in 63 carcinoma specimens were 34 . 9 % for GST pi , 44 . 4 % for c Jun , 34 . 9 % for c Fos , 47 . 6 % for c H Ras , and 54 . 0 % for c Myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of cytochrome c ( cyt c ) transcription in electrically stimulated neonatal rat cardiac myocytes is preceded by transient expression of the activating protein 1 family of transcription factors , c Fos , c Jun , and JunB , as well as nuclear respiratory factor 1 ( NRF 1 ) . ^^^ Chem . 272 , 24046 24053 ) so that the fold activation of the cyt c promoter is increased by pacing when either c jun or c fos / c jun were cotransfected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The osteogenic sarcoma cell line expressed the entire repertoire bone morphogenetic proteins 1 to 7 , c fos and c jun messenger ribonucleic acids . ^^^ Myositis ossificans traumatica cells expressed phenotype markers similar to those of the osteogenic sarcoma cells , and expressed bone morphogenetic proteins 1 , 4 , and 6 and c fos messenger ribonucleic acids , but not c jun messenger ribonucleic acid . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the early response gene c fos remained intact , but DHEA and 16 alpha bromoepiandrosterone decreased DNA binding of the transcription factor activator protein 1 , a later response important for expression of genes that mediate DNA synthesis and cell cycle progression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As for AP 1 proteins , judging by the results of the Western blotting assay , the level of c Fos increased while that of c Jun decreased with TCDD treatment both at day 1 and 28 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In exponentially growing cells as well as in cells synchronized by serum starvation , expression of the E 6 gene was associated with upregulation of the c fos and c jun proto oncogenes and with downregulation of the c Ha ras gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : MMP 1 , MMP 3 , c fos , and c jun messenger RNA ( mRNA ) levels were measured in interleukin 1 ( IL 1 ) induced primary chondrocytes in the presence and absence of paclitaxel . ^^^ However , there was no effect on the expression of c fos or c jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Apigenin also reduced the level of TPA stimulated phosphorylation of cellular proteins and inhibited TPA induced c jun and c fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Given that immediate early genes ( IEGs ) participate in signal transduction pathways that mediate programmed cell death , the present study utilized in situ hybridization and immunohistochemistry to examine the expression of four IEGs ( c fos , c jun , fos B , and NGFI A ) during the progression of PTD . ^^^ At the acute symptomatic stage ( characterized by a loss of righting reflex on d 16 17 ) , the posterior medial thalamus exhibited increased mRNA for all genes examined , whereas the inferior colliculus demonstrated mRNA induction for c fos , c jun , and NGFI A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , after 20 d in culture in the STLV , we observed altered patterns of protein tyrosine phosphorylation and prolonged activation of c fos , a member of the AP 1 nuclear transcription factor complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It also reduces 12 O tetradecanoylphorbol 13 acetate ( TPA ) induced increases in skin inflammation , epidermal DNA synthesis , ornithine decarboxylase ( ODC ) mRNA level , ODC activity , hyperplasia , formation of c Fos , and c Jun proteins , hydrogen peroxide , and the oxidized DNA base 5 hydroxymethyl 2 ' deoxyuridine ( HmdU ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JNK and ERK activations were followed by a 3 . 9 fold increase in arterial AP 1 DNA binding activity , which contained c Jun and c Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with its effects on VSMC growth / proliferation , amlodipine also decreased c myc , c fos , and c jun protooncogene expression induced by serum , thrombin , or bFGF within 1 h after cell activation , as assessed by semiquantitative reverse transcriptase ( RT ) polymerase chain reaction ( PCR ) analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Glucocorticoids stimulate TRH and c fos / c jun gene co expression in cultured hypothalamic neurons . ^^^ To explore whether the protooncogenes , c fos / c jun , might be involved in regulating the effect of glucocorticoids on thyrotropin releasing hormone in fetal rat diencephalic neurons , their localization and transcriptional activity were investigated using double labeled in situ hybridization , Northern blot and nuclear run on assays . ^^^ The results showed that TRH mRNA was coexpressed with both c jun and c fos in the same neurons . ^^^ The existence of c fos / c jun in thyrotropin releasing hormone neurons and the increased transcriptional activity following dexamethasone treatment suggests that these protooncogenes could mediate the effect of glucocorticoids on thyrotropin releasing hormone gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : The effects of rhIL 6 on the expressions of IL 6 , IL 6R , c myc , c fos and c jun mRNAs were analyzed by Northern blotting hybridization . ^^^ Northern blotting hybridization revealed that rhIL 6 up regulated mRNA levels of IL 6 , IL 6R and c myc rather than those of c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of ultraviolet B ( UVB ) induced c fos and c jun expression in vivo by a tyrosine kinase inhibitor genistein . ^^^ We reported the inhibitory effects of genistein , an inhibitor of tyrosine protein kinase ( TPK ) , on ultraviolet B ( UVB ) induced expression of c fos and c jun in SENCAR mouse skin . ^^^ UVB irradiation substantially increased transcript levels of c fos and c jun mRNA in mouse skin . ^^^ Topical application of genistein 60 min before UVB radiation reduced c fos and c jun expression in the mouse skin in dose dependent manner . ^^^ In addition , genistein exhibited more inhibition of c fos than that of c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous studies in a model of unilateral hypoxia ischemia in the developing rat brain have shown induction of the mRNAs of c fos and c jun and presence of apoptotic DNA fragmentation . ^^^ Since c fos and c jun have been involved in several models of cell death , we investigated whether the neuroprotective effect of dexamethasone could be associated with changes in expression of these genes . ^^^ Analysis of c fos and c jun expression at 2 h , by means of in situ hybridization , revealed diminished induction in dexamethasone treated animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The blockade of KA induced proENK and proDYN mRNA levels by the pre treatment with L ARG was well correlated with proto oncoprotein levels , such as c Fos , Fra 2 , FosB , JunD , JunB , and c Jun , as well as AP 1 and ENKCRE 2 DNA binding activities . ^^^ In addition , L NAME potentiated the c Fos or c Jun gene expression , as well as AP 1 or ENKCRE 2 DNA binding activity . ^^^ The pre administration with L NAME further increased KA induced c jun and c fos mRNA levels in addition to their protein product levels , although the pre treatment with L NAME did not affect KA induced FosB , Fra 2 , JunB , and JunD protein levels at 6 h after treatment . ^^^ Our results suggest that L ARG plays an important role in inhibiting KA induced proENK or proDYN mRNA expression , and its inhibitory action may be mediated through reducing the proto oncoprotein levels , such as c Fos , Fra 2 , FosB , c Jun , JunD , and JunB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Accompanying this attenuation was an activation of c fos and BDNF genes and an inactivation of c jun and neurotrophin 3 ( NT 3 ) genes . ^^^ In good agreement with this observation , the mode of activation of c fos , c jun , BDNF and NT 3 genes induced by exogenous BDNF was different from that induced by membrane depolarization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun mRNA following transient retinal ischemia : an approach using ligation of the retinal central artery in the rat . ^^^ The expression of the proto oncogenes c fos and c jun was examined by in situ hybridization at various timepoints following transient retinal ischemia by means of ligation of the retinal central artery in the rat . ^^^ The expression of c fos and c jun messenger RNA throughout the entire inner nuclear layer was transiently coinduced following 90 minute retinal ischemia with a peak at 1 hour after reperfusion . ^^^ Weak signals for c fos and c jun mRNA were observed at 24 hours after reperfusion and returned to near control levels by 48 hours . c jun protein expression was detected in the ganglion cell layer , the middle of the inner nuclear layer , and optic nerve head at 3 hours , but not 1 hour , after lethal ischemia / reperfusion ; however , c fos protein expression was not detected after reperfusion . ^^^ Whereas no neuronal degenerative changes were found at 7 days after 30 minute ischemic retina , c fos and c jun messenger RNA were also induced at 1 hour postreperfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrate that overexpression of c Jun but not c Fos increases IL 2 promoter activity in both B 7 1 and LFA 3 costimulated Jurkat T cells . ^^^ Cotransfection of both c Jun and c Fos substitutes for B 7 1 costimulation in driving an activation protein 1 response element but not for the IL 2 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
UVB irradiation potently induced c jun , junB and c fos mRNA levels in vitro in HaCaT cells . ^^^ IL 6 mRNA was induced in response to UVB irradiation 2 3 h later than c jun , junB and c fos mRNAs . ^^^ The results of this study provide evidence that in addition to c jun and c fos , junB is also an essential component of the human UV response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 1 regulation of corticotropin releasing factor ( CRF ) , glucocorticoid receptor , c fos and c jun messenger RNA in the NPLC KC cell line . ^^^ In this report , we have examined the effect of IL 1 ( beta form ) in the presence and absence of DEX on CRF mRNA ( mRNA ) expression as well as the expression of human glucocorticoid receptor ( GR ) mRNA and the mRNA of the proto oncogenes ( c jun and c fos ) that have been implicated in CRF regulation . ^^^ Following this total RNA was extracted from the cells and Northern Blots were probed with 32P labelled human DNA probes for the CRF , GR , c jun and c fos genes . ^^^ Levels of the GR , c fos and c jun mRNAs were also significantly increased in the presence of IL 1 and inhibited when DEX was co incubated with IL 1 . ^^^ The results reveal that IL 1 stimulation of CRF mRNA expression by IL 1 in the NPLC KC cell line is accompanied by activation of GR mRNA as well as the mRNA of the immediate early genes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrated increased binding activity to the AP 1 and CREB / ATF 2 consensus binding sites and show that the AP 1 complex is composed of c Jun , JunD , c Fos , and ATF 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Footprinting after immunoprecipitation indicates that Egr 1 , Egr 2 and Sp 1 could bind to P 3 promoter directly , while c jun and c fos could not bind to these region directly . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study demonstrates 1alpha , 25 dehydroxyvitamin D 3 ( 1alpha 25 ( OH ) 2D3 ) synergism toward transforming growth factor ( TGF ) beta 1 induced activation protein 1 ( AP 1 ) activity in mouse osteoblastic MC3T3 E 1 cells via the nuclear receptor of the vitamin . 1alpha 25 ( OH ) 2D3 synergistically stimulated TGF beta 1 induced expression of the c jun gene in the cells but not that of the c fos gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We studied the effects of Ang 2 on ASM cell proliferation and growth and on the expression of three transcription factors , egr 1 , c fos , and c jun , as well as a cytokine , transforming growth factor beta 1 ( TGF beta 1 ) . ^^^ Ang 2 stimulated the expression of egr 1 and c fos as early as 15 min , reaching maximum levels at 45 min , whereas the expression of c jun peaked at 2 h of Ang 2 exposure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast to IL 4 , IL 2 induces the expression of c fos and c jun family genes , mediated by the acidic region ( A region ) within the cytoplasmic domain of IL 2R beta . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the other hand , Northern blot analysis showed a different pattern of expression for the genes , c fos , c jun , c Ha ras , transin ( rat stromelysin ) , bone Gla protein ( osteocalsin ) and nm23 / NDP kinase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis in the presence of antibodies to c Jun , c Fos , JunD , and JunB suggested that AP 1 complexes were composed of c Fos , JunB , and possibly c Jun . ^^^ The delayed increase in COX 2 mRNA expression was accompanied by the induction of the proto oncogenes c jun , junB , junD , and c fos ( but not FosB or Fra 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A rapid and transient increase in c fos , junB , c jun and Tis 11 messenger RNA was observed in cultured astrocytes after treatment with adenosine 5 ' O ( 2 thiodiphosphate ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c jun , junB , c fos , fra 1 and fra 2 mRNA in the rat brain following seizure activity and axotomy . ^^^ The patterns of c jun , junB , c fos , fra 1 and fra 2 mRNAs were studied by radioactive and non radioactive in situ hybridization in the adult rat brain following kainate induced seizure activity and axotomy . ^^^ In the same animals , the expression of c Jun , JunB and c Fos proteins was compared with the respective mRNA signals . ^^^ Whereas fra 1 and fra 2 were restricted to the hippocampus , c jun , junB and c fos were additionally induced in the cortex , amygdala and thalamus . ^^^ The expression patterns between c jun , junB and c fos mRNA were virtually congruent with the respective protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In mammalian cells , the ribotoxic stress response involves activation of the stress activated protein kinase / c Jun NH 2 terminal kinase and the p 38 mitogen activated protein kinase and transcriptional induction of immediate early genes such as c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that elevation of cytoplasmic HuR levels inhibits c fos ARE mediated RNA decay but has little effect on rapid decay directed by c jun ARE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Due to the role of Activator Protein 1 ( AP 1 ) in rGSTP 1 1 expression and CYP 1A2 in the pathogenesis of porphyria cutanea tarda , immunohistochemical localization of c jun , c fos , and CYP 1A2 was also performed . ^^^ Increased expression and colocalization within the liver lobule was observed for c jun , c fos , CYP 1A2 , rGSTP 1 1 , and areas of porphyrin accumulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In cultured cells , MC causes the induction of AP 1 activity , which is the result of an increased expression of c Fos and c Jun proteins . ^^^ Signaling pathways in the induction of c fos and c jun proto oncogenes by 3 methylcholanthrene . 3 methylcholanthrene ( MC ) , a potent promutagen and procarcinogen , is also an inducer of mammalian CYPIAI ( cytochrome P 1 450 ) gene . ^^^ The mechanisms involved in MC activation of c fos and c jun gene expression were examined in the present study . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 2 receptor signaling is a complex process involving a large number of molecules : Ras , Rho , PI 3 kinase , PKC , Akt , transcription factors NF AT , and NF kappaB and some target genes such as bcl 2 , c myc , c jun and c fos . ^^^ These three channels serve as major landmarks : Lck c fos / c jun ( channel 1 ) , Syk myc ( channel 2 ) , and a pathway leading to actin organization / bcl 2 expression ( channel 3 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
T cell receptor stimulation also induced a very rapid expression of c jun , c fos and NFATc 1 ( NFATc ) genes , the gene products of which are involved in cytokine gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , overexpression of p 202 in transfected cells inhibits the transcriptional activity of E2Fs ( E2F 1 / DP 1 and E2F 4 / DP 1 ) , p 53 , AP 1 c Fos and c Jun , NF kappaB p 50 and p 65 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Steroid receptor coactivator 1 ( SRC 1 ) specifically bound to the transcription factor AP 1 subunits c Jun and c Fos , as demonstrated by the yeast two hybrid tests and glutathione S transferase pull down assays . ^^^ Steroid receptor coactivator 1 coactivates activating protein 1 mediated transactivations through interaction with the c Jun and c Fos subunits . ^^^ The c Jun and c Fos binding sites were localized to the C terminal subregion of SRC 1 ( amino acids 1101 1441 ) that encompasses the previously described histone acetyltransferase and receptor binding domains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In F 28 7 cells , FdUrd induced increases in caspase 3 like activity , and the mRNA levels of the c jun , c fos and c myc genes , which were greater and earlier than those in F 28 7 A cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A gene candidate approach revealed that mRNA levels of the oncogenes c fos and c jun were equivalently expressed in insulinoma and islet cells , as was the mRNA for the mitogenic signal transduction molecule insulin receptor substrate ( IRS ) 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , tyrosine phosphorylation and activation of mitogen activated protein ( MAP ) kinase as well as c fos and c jun gene expression were augmented only in ECL cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Presumably , the activation of the c fos gene leads to the subsequent formation of the transcription factor activator protein 1 ( AP 1 ) , since accumulation of c fos mRNA is followed by induction of target genes sensitive to AP 1 such as plasminogen activator inhibitor type 2 ( PAI 2 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We studied the mRNA accumulation of the transcription factors c fos , c jun , and C / EBP alpha and the cytokines interleukin 1 and interleukin 6 using reverse transcriptase polymerase chain reaction . ^^^ RESULTS : Compared with the control , ovarian carcinoma in the mouse model resulted in the following : ( 1 ) Pituitary c fos and c jun mRNA increased 3 fold ( P = 0 . 012 ) and 6 fold ( P < 0 . 001 ) , respectively ; ( 2 ) pituitary IL 1 and IL 6 mRNA increased 4 fold ( P < 0 . 001 ) and 8 fold ( P = 0 . 037 ) , respectively ; ( 3 ) liver c fos mRNA increased > 8 fold ( P < 0 . 001 ) ; and ( 4 ) lung C / EBP alpha mRNA decreased greater than 10 fold ( P < 0 . 001 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we report that alpha 1 B ARs inhibit the activities of alpha 1A ARs in neonatal rat myocardium so that the inactivation of alpha 1 B ARs by chloroethylclonidine ( CEC ) potentiated the effects of nonselective alpha 1 AR agonist phenylephrine ( PE ) on myocardial protein synthesis and early gene ( c fos and c jun ) expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The glucocorticoid receptor ( GR ) is a ligand activated nuclear transcription factor , and AP 1 ( Fos / Jun or Jun / Jun ) is a transcription factor whose components are nuclear proteins encoded by c fos and c jun protooncogenes . ^^^ Serum stimulation of serum starved NIH 3T3 cells resulted in an approx 188 fold induction of c fos mRNA at 30 min and an approximately ninefold induction of c jun mRNA at 1 h , followed by an increase in GR mRNA levels at 3 12 hour ( twofold ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , deficient protein kinase C ( PKC ) alpha , PKC / betaI , and PKC betaII activation , deficient mitogen activated protein kinase ( MAP Kinase ) activation , and deficient expression of c Fos and c Jun was observed in LPS activated aged monocytes when compared with LPS activated young monocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We previously demonstrated a reduction in basal AP 1 transcriptional activity associated with the malignant transformation of human bronchial epithelial ( HBE ) cells that was , in part , a consequence of decreased c fos expression . ^^^ Further , the activity of the Jun N terminal Kinase ( JNK ) dependent pathway , which was a positive regulator of the c fos promoter , was greater in normal HBE cells than in tumorigenic HBE cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The intracellular incorporation of Abs specific for c Fos and c Jun family members by scrape loading inhibited the production and intracellular accumulation of IL 2 within 6 h of costimulation with PMA / ionomycin , or costimulation by CD 28 and CD 3 ligation . ^^^ Scrape loading thus provides an efficient mechanism for intracellular incorporation of macromolecules , and the first direct evidence that c Fos and c Jun are involved in transcription of the IL 2 gene within its correct chromosomal context , in resting human T lymphocyte subpopulations . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The products of c fos and c jun proto oncogenes form the heterodimeric complex AP 1 ( activator protein 1 ) , which play an important part in the control of bone cell proliferation and differentiation and in the development of bone tumours . ^^^ Immunohistochemical detection of c fos and c jun expression in osseous and cartilaginous tumours of the skeleton . ^^^ We examined the expression of c fos and c jun in a series of 52 primary skeletal neoplasms , using an immunohistochemical method on formalin fixed , paraffin embedded sections . ^^^ The expression of c fos and c jun was restricted to bone forming lesions , while cartilaginous tumours were devoid of immunoreactivity . ^^^ In benign osteoblastic lesions moderate c fos and c jun expression was found in 2 cases ( 18 . 1 % ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of c jun and c fos genes in dNTP imbalance cell death induced with 5 fluoro 2 ' deoxyuridine in mouse mammary tumor FM3A cell line . 5 Fluoro 2 ' deoxyuridine ( FdUrd ) induced death of mouse mammary FM3A cells was found to be associated with an increased expression of cellular c jun and c fos genes . ^^^ These findings suggest that the activation of c jun and c fos genes , which encode transcription factors participating in cell proliferation , plays a role in FdUrd induced cell death . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study was designed to identify brain regions that demonstrate specific induction of the IEG c fos , a component of the AP 1 transcription factor , in response to acute morphine , and to contrast this induction with the stressful effects of the injection itself . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To evaluate the role of early growth genes in TCM 120 induced KF proliferation , TCM 120IP treated cells were probed with cDNA for c fos and c jun . ^^^ TCM 120IP at a lower concentration ( 20 % ) also enhanced KF mRNA expression of c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Amylin treatment results in time and concentration dependent inductions of oxidative stress genes , such as cox 2 and IkappaB alpha . `` Apoptotic ' ' genes are also induced in a time and concentration dependent manner , including c jun , junB , c fos , and fosB , followed temporally by a gene known to be modulated by these transcription factors , i . e . , transin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The differential induction of two immediate early genes , c fos and c jun , after systemic hypovolemic shock / resuscitation in the rat liver and kidney . ^^^ The aim of this study was to investigate the expression of the immediate early genes ( IEGs ) , c fos and c jun , in the rat kidney and liver in two types of hemorrhage shock / resuscitation models . ^^^ In the first group , a rapid and transient induction of c fos and c jun mRNAs in both the liver and kidney was observed , peaking 0 to 2 h after reperfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We discuss in detail a ) the nature and activation of these pathways b ) how they induce c fos expression and c ) how these MAPK cascades can differentially regulate the activity of AP 1 and thereby osteoblast specific gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Genetic studies including gain of function and loss of function mutations have shown that AP 1 components , particularly the c Fos protein , are essential for proper bone development . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In HGF treated HepG 2 cells , we studied : ( 1 ) the expression patterns of early ( c myc , c jun , and c fos ) and delayed early ( ornithine decarboxylase and c met ) response genes and ( 2 ) the possible involvement of protein kinase transducers in the control of the expression of c met and of other genes eventually induced downstream . c met and c myc mRNAs peaked 1 2 h after HGF , while c jun and c fos mRNAs slightly increased at 1 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cryogenic brain injury resulted in c fos and c jun mRNA expression throughout the ipsilateral cortex , piriform cortex and dentate gyrus on the injured side , with peak at 30 min to 1 h post injury . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Preliminary evidence suggests that c fos levels and AP 1 binding may be regulated by lithium and VPA , but the results are inconclusive . ^^^ At therapeutically relevant concentrations , both drugs acutely ( < 24 h ) induced c Fos immunoreactivity and AP 1 binding . ^^^ The present results confirm and extend previous findings on the regulation of c fos expression and AP 1 binding after administration of mood stabilizers , and further elucidate the mechanisms through which VPA increases AP 1 DNA binding . . ^^^ Lithium and sodium valproate ( VPA ) are effective in the treatment of bipolar disorder ( BD ) and may function through the regulation of signal transduction pathways and transcription factors such as c fos and c Jun , which in turn results to changes in gene expression . ^^^ In contrast to lithium , chronic ( 1 week ) treatment with VPA led to continued induction of c Fos , in addition to induction of c Jun immunoreactivity and a 33 35 kDa band previously identified as chronic FRA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In response to NE , both 42 and 44 kD MAPK were activated and tyrosine was phosphorylated . alpha 1 Adrenoceptor stimulation with NE also caused accumulation of c fos , c jun , and c myc mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Though a definitive role for IL 6 to modulate the function of PMNL was not found , treatment of PMNL with rh IL 6 clearly resulted in an enhancement of transcript levels of the early response genes c fos and c jun in these cells , thus indicating that IL 6 binding is followed by signal transduction . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The concentration of c fos , c jun , c myc , junB , and fra 1 mRNAs was increased in activated peripheral blood lymphocytes incubated with ciprofloxacin compared to that in untreated controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , we investigated the expression pattern of the inducible transcription factors ( ITF ) c Fos , c Jun , JunB , JunD , and Krox 24 following intracerebroventricular injections of hyperosmolar saline ( 0 . 2 , 0 . 3 , and 0 . 6 M NaCl ) and its mediation via angiotensin and / or muscarinic receptors . c Fos , c Jun , and Krox 24 were differentially expressed in organum vasculosum laminae terminalis , median preoptic area , subfornical organ ( SFO ) , and paraventricular and supraoptic nuclei . ^^^ Expression of c Fos and c Jun was inhibited by pretreatment with the angiotensin AT 1 receptor antagonist losartan ( 10 and 20 nmol icv ) following 0 . 20 and 0 . 30 M saline . ^^^ Pretreatment with atropine ( 15 nmol icv ) inhibited the 0 . 30 and 0 . 60 M NaCl induced expression of c Fos , c Jun , and Krox 24 in all areas except the SFO . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These data strongly suggest that c fos and c jun are involved in regulating chondrocyte proliferation as immediate early genes , and may also be involved in the gene expression of bone matrix proteins as transcription factor ( AP 1 ) in vivo . ^^^ Distribution and expression of mRNAs for the proto oncogenes c fos and c jun in bone cells in vivo . ^^^ In this study we assessed the expression and localization of the proto oncogenes c fos and c jun in normal bone so as to gain more insight into the role of these proto oncogenes in bone tissue . ^^^ Femurs of 4 week old rats were examined by non radioactive in situ hybridization . cDNA probes for c fos and c jun labeled digoxygenin were produced by Polymerase Chain Reaction ( PCR ) . ^^^ C fos and c jun exhibited similar distribution in growth plate and bone tissue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
SCFAs increased ileal c myc , c jun , and c fos expression following 24 hr ( P < 0 . 02 ) , 12 hr ( P < 0 . 05 ) and 6 , 12 , and 24 hr ( P=0 . 0001 ) , respectively . ^^^ In conclusion , systemic SCFAs increase plasma GLP 2 and ileal proglucagon mRNA , GLUT 2 expression and protein , and c myc , c jun , and c fos expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential directing of c Fos and c Jun proteins to the proteasome in serum stimulated mouse embryo fibroblasts . c Fos and c Jun proteins are highly unstable transcription factors that heterodimerize within the AP 1 transcription complex . ^^^ To address the mechanisms responsible for rapid clearance of c Fos and c Jun proteins under these experimental conditions , we have used the ts 20 mouse embryo fibroblasts which express a thermosensitive mutant of the E 1 enzyme of the ubiquitin pathway . ^^^ Interestingly , c Jun is highly unstable in c Fos null mouse embryo fibroblasts stimulated for growth . ^^^ Taken together , these observations show that in vivo during a G 0 to S phase transition ( 1 ) the precise mechanisms triggering c Fos and c Jun directing to the proteasome are not identical , ( 2 ) the presence of c Fos is not an absolute prerequisite for the degradation of c Jun and ( 3 ) the degradation of c Jun is not required for that of c Fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Limited proteolysis by Staphylococcus aureus V 8 protease as well as supershift assays using antibodies against c Fos and c Jun proteins demonstrated the possible difference in constructive partner proteins of activator protein 1 among nuclear extracts of the CA 1 subfield obtained from gerbils with single , tolerated and repeated ischemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both beta NF and hypoxia induce similar changes : 1 ) induction of CYP1A1 mRNA ; 2 ) increased glucose consumption and lactic acid production and lower glycogen content ; 3 ) downregulation of SI and upregulation of GLUT 1 mRNAs ; 4 ) downregulation of fructose 1 , 6 bisphosphatase and pyruvate kinase mRNAs and upregulation of phosphoenolpyruvate carboxykinase , pyruvate dehydrogenase , lactate dehydrogenase , and phosphofructokinase mRNAs ; and 5 ) upregulation of c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As assessed by gel mobility shift assay , glomerular DNA binding activity of AP 1 containing both c Jun and c Fos and NF kappaB composed of P 50 and P 65 subunits was significantly increased after ATS injection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proto oncogenes are involved in the regulation of cell cycle and PCD , and adrenocorticotropin asserts its tissue integrating and differentiating effects by regulating proto oncogenes such as c jun , c fos , jun B and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Do c Jun , c Fos , and amyloid precursor protein play a role in neuronal death or survival . ^^^ A unilateral hypoxic ischemic ( HI ) episode in immature rat brain was used to investigate the role of the immediate early genes c fos and c jun in delayed neuronal death and survival . ^^^ In susceptible regions undergoing delayed neuronal death there was a prolonged induction of both c Jun and c Fos ( mRNA and protein ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has been proposed that this depolarization may result in N Methyl D Aspartate receptor mediated excitotoxicity as well as increased expression of immediate early genes such as c fos and c jun resulting in apoptotic cell death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the current study , we used in situ hybridization autoradiography to assess the effects of delayed hyperthermia on the regional expression of messenger RNA ( mRNA ) for the immediate early genes c fos and c jun , the inducible heat shock protein 70 ( hsp 70 ) and glial fibrillary acid protein ( GFAP ) following 1 h of transient middle cerebral artery occlusion ( MCAo ) produced in rats by the insertion of an intraluminal suture . ^^^ Low level constitutive c fos and c jun expression in sham occluded rats was unaffected by delayed temperature manipulation . ^^^ Prior MCAo decreased c fos and c jun mRNA in the affected striatum and overlying cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the possible molecular mechanisms of erionite induced toxicity and carcinogenesis and whether cationic content of erionite fibers was important , we examined c fos and c jun mRNA levels , activator protein 1 ( AP 1 ) binding to DNA , and changes in cell proliferation and apoptosis in rat pleural mesothelial ( RPM ) cells exposed to different cation substituted erionite fibers or crocidolite asbestos at various concentrations ( 1 , 5 , or 10 microg / cm2 dish ) at time periods from 8 to 48 h after addition of minerals . c fos mRNA levels in cells exposed to equal weight concentrations of various erionites and crocidolite fibers were increased comparably . ^^^ Patterns of c fos and c jun proto oncogene expression , apoptosis , and proliferation in rat pleural mesothelial cells exposed to erionite or asbestos fibers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The purpose of this study was ( 1 ) to define the signaling mechanisms regulating neurotensin and ( 2 ) to determine whether the AP 1 transcription factor c Fos is induced . ^^^ CONCLUSIONS : Our results demonstrate that neurotensin binds to its endogenous NTR in KM 20 cells with stimulation of the Ca ( 2+ ) and MAPK signaling pathways and an increase in the levels of the AP 1 protein c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analyses were performed with cDNA probes specific for c fos , c jun , and actin . ^^^ In response to EGF treatment , SS cells exhibited a growth spurt and induced c fos and c jun proto oncogene expression , whereas butyrate treated cells exhibited minimal growth response to EGF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The C terminal domain of c fos is required for activation of an AP 1 site specific for jun fos heterodimers . ^^^ We have identified in the promoter of the rat atrial natriuretic factor ( ANF ) a novel AP 1 site which is unresponsive to jun homodimers and is inducible only in the presence of c fos . ^^^ Unexpectedly , the oncogenic form of c fos which diverges most significantly in the carboxy terminal 50 amino acids is unable to mediate transactivation at this specialized AP 1 site . ^^^ These results suggest that phosphorylation of the C terminus of c fos affects its transactivation properties and provide evidence for novel regulatory mechanisms that may contribute to biologic specificities of the AP 1 transcription complex . . ^^^ The jun proteins appear to be required solely to tether c fos to the promoter , and c fos mutants lacking putative activation domains abrogate transactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest that the sequence involving the hydrolysis of membrane glycolipids and the expression of c jun and c fos proto oncogenes is part of the mechanism that activates cell division in response to insulin and IGF 1 during early organogenesis of the avian inner ear . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Specific antibodies were used to confirm that the OA induced complex is related to AP 1 and to show that it contains JunD and c fos , but not Pit 1 . ^^^ The increase in AP 1 binding to P 1 and to a canonical AP 1 site correlates to an increase in cellular JunD and c fos content . ^^^ Our results demonstrate that a member of the AP 1 family , containing JunD and c fos , can bind to the proximal element P 1 within the hPRL promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction analysis of c fos , c jun and c myc mRNA levels demonstrated that c jun mRNA level after serum stimulation was significantly reduced by 10 ( 5 ) M EGC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The increase in ERCC 1 mRNA was preceded by a 4 5 fold rise in mRNA expressions of c fos and c jun , a 14 fold increase in c Jun protein phosphorylation , and an increase in in vitro nuclear extract binding activity to the AP 1 like site of ERCC 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : The expression of Ki 67 antigen , c Fos , c Jun and c Myc in the smooth muscle layer of obstructed ureters was determined using immunohistochemistry in 40 Sprague Dawley rats . ^^^ However , the expression of c Fos and c Jun was low and transient . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Coexpression of c jun and c fos , which are increased by GnRH and PMA , suppressed basal alphaLUC activity , but did not alter the sensitivity to GnRH in a sexually dimorphic manner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The levels of c jun , c fos , junB , and fosB mRNA in ZG and ZFR were also rapidly maximally elevated within 0 . 5 1 h after ACTH administration and fell to near control levels 5 h posttreatment . ^^^ Although c fos and fosB mRNAs were undetectable after 9 days of chronic ACTH treatment , c jun mRNA and its protein were still detectable , suggesting a basic role for this protooncogene in maintaining the integrity and function of the adrenal cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Restraint stress induced accumulation of c fos , jun B , and NGFI B mRNA , and CRF hnRNA in the PVN was significantly higher in young and adult SHRSP than in WKY rats at 30 min , except for c fos in young rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this report , we demonstrate that the cAMP mediated regulation of transcription from the dopamine beta hydroxylase promoter is mediated by the AP 1 proteins c Fos , c Jun , and JunD . ^^^ Following treatment of cultured cells with cAMP , protein complexes bound to the dopamine beta hydroxylase AP1 / cAMP response element element change from consisting of c Jun and JunD to include c Fos , c Jun , and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using antisense c fos strategy , we tested the hypothesis that c fos is essential for activation of activator protein 1 transcription factor complex ( AP 1 ) and subsequent stimulation of down stream genes such as tyrosine hydroxylase ( TH ) gene during hypoxia . ^^^ Role of c fos in hypoxia induced AP 1 cis element activity and tyrosine hydroxylase gene expression . ^^^ Antisense c fos abolished hypoxia induced AP 1 activation in PC 12 cells . ^^^ Hypoxia increased tyrosine hydroxylase chloramphenicol acetyl transferase activity ( TH CAT ) , and antisense c fos and mutations at AP 1 binding sites in TH promoter abolished this effect . ^^^ These results provide direct evidence that c fos is essential for functional activation of AP 1 and subsequent activation of delayed response genes such as TH in PC 12 cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In accord with the stimulation of Elk 1 phosphorylation , BK induced c fos gene expression and the production of Fos / AP 1 complexes . ^^^ In contrast , protein kinase C inhibition or depletion had no effect on BK induced c fos mRNA , AP 1 DNA binding activity , or DNA synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This hypothesis was supported by showing AP 1 binding to two target sequences of the MGMT promoter and transactivation of the MGMT promoter upon cotransfection with c fos and c jun in F 9 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Chronic ethanol intake may interfere with retinoid signal transduction by inhibiting retinoic acid synthesis and by enhancing activator protein 1 ( AP 1 ) ( c Jun and c Fos ) expression , thereby contributing to malignant transformation . ^^^ Chronic alcohol intake reduces retinoic acid concentration and enhances AP 1 ( c Jun and c Fos ) expression in rat liver . ^^^ To determine the effect of ethanol on hepatic retinoid levels , retinoic acid receptors ( RARs ) and AP 1 ( c Jun and c Fos ) gene expression , chronic ethanol ( 36 % of total calorie intake ) pair feeding was conducted on rats for a 1 month period . ^^^ Both retinoic acid receptor ( alpha , beta , gamma ) and AP 1 ( c Jun and c Fos ) expression in the rat liver were examined by using Western blot analysis . ^^^ However , chronic alcohol feeding enhanced AP 1 ( c Jun and c Fos ) expression by 7 to 8 fold , as compared with the control group . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Acute shear stress in vitro elicits rapid cytoskeletal remodeling and activates signaling cascades in ECs , with the consequent acute release of nitric oxide and prostacyclin ; activation of transcription factors nuclear factor ( NF ) kappaB , c fos , c jun and SP 1 ; and transcriptional activation of genes , including ICAM 1 , MCP 1 , tissue factor , platelet derived growth factor B ( PDGF B ) , transforming growth factor ( TGF ) beta 1 , cyclooxygenase 2 , and endothelial nitric oxide synthase ( eNOS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Glucose and glucoincretin peptides synergize to induce c fos , c jun , junB , zif 268 , and nur 77 gene expression in pancreatic beta ( INS 1 ) cells . ^^^ Glucose causes a coordinated transcriptional activation of the IEGs c fos , c jun , JunB , zif 268 , and nur 77 in the pancreatic beta cell line INS 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Correlation between potentiation of AP 1 DNA binding and expression of c Fos in association with phosphorylation of CREB at serine 133 in thalamus of gerbils with ischemia . ^^^ These results suggest that potentiation of AP 1 DNA binding may at least in part involve mechanisms associated with the expression of c Fos protein through phosphorylation of CREB at serine 133 in the thalamus of gerbils with ischemia . . ^^^ The ischemic insult not only increased the immunoreactivity with an antibody against cyclic AMP response element binding protein ( CREB ) phosphorylated at serine 133 , but also induced the expression of both c Jun and c Fos family proteins 3 h after the recirculation in the thalamus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Insulin stimulated expression of c fos , fra 1 and c jun accompanies the activation of the activator protein 1 ( AP 1 ) transcriptional complex . ^^^ The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^ In the current study we show that the AP 1 complex isolated from insulin stimulated cells contained c Fos , Fra 1 , c Jun and JunB . ^^^ The activation of the AP 1 complex by insulin was accompanied by ( 1 ) a transient increase in c fos expression , and the transactivation of the ternary complex factors Elk 1 and Sap1a , in an Erk1 / Erk2 dependent fashion ; ( 2 ) a substantial increase in the expression of Fra 1 protein and mRNA , which was preceded by a transient decrease in its electrophoretic mobility upon SDS / PAGE , indicative of phosphorylation ; and ( 3 ) a sustained increase in c jun expression without increasing c Jun phosphorylation on serines 63 and 73 or activation of the stress activated kinase JNK / SAPK . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , when components of AP 1 factors were overexpressed by transfecting Y 1 cells with their expression vectors , a paired expression of AP 1 components such as c Jun and c Fos , which were inducible by corticotropin , transactivated the CYP11B1 promoter more strongly in the absence of corticotropin than other combinations such as JunD and Fra 2 expressed constitutively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Augmented JNK activity was accompanied by increased nuclear abundance of c jun and c fos proteins that bound specifically to the proximal c jun promoter CRE element . ^^^ Also , representative human leukemic cell lines expressing p 210 BCR ABL and possessing abundant kinase activity of JNK , when compared with parental cells that were deficient in JNK activity , had increased c jun and c fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential expression of the estrogen regulated proto oncogenes c fos , c jun , and bcl 2 and of the tumor suppressor p 53 gene in the male mouse chronically infected with Taenia crassiceps cysticerci . ^^^ The aim of this study was to investigate the expression pattern of c fos and c jun , two estradiol regulated genes , as well as that of p 53 and bcl 2 in the testes , spleen , and thymus of male mice infected with T . crassiceps cysticerci . ^^^ In parasitized animals the c fos mRNA content was significantly increased in all tissues studied , whereas the c jun mRNA content was increased only in the thymus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One hour after the intraperitoneal administration of delta 9 THC at a dose of 10 or 15 mg / kg , AP 1 DNA binding activity in the nucleus accumbens increased by 33 and 49 % , respectively , while Western blot showed an increase in both c Fos , FosB , Fra 1 ( Fos related antigen ) and Fra 2 . ^^^ While in the caudate putamen the increase in AP 1 DNA binding was mainly due to an elevation of the c Fos and FosB proteins , the same phenomenon depended on the FosB , Fra 1 and Fra 2 peptides in the cingulate cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The early biochemical events show the impairment of energy metabolism , and the process may require new synthesis of proteins such as c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrated that a single intraperitoneal injection of NMDA produces persistent expression of c fos , c jun , Fas , and Fas ligand ( FasL ) mRNA in the hippocampus for 5 months . ^^^ To determine the cellular origin of those gene transcripts in our in vivo model , a glial cell line and primary fetal neuronal culture were used to investigate the inducibility of the c fos , c jun , Fas , and FasL mRNA by NMDA . ^^^ Both c fos and Fas mRNA expression was observed in the NMDA treated glial or neuronal cultures ; however , c jun and FasL mRNA was undetectable in this study . ^^^ Therefore , we hypothesize that the observed long term expression of c fos , c jun , Fas , and FasL mRNAs may reflect the ongoing synaptic reorganization . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Intraperitoneal injections of various doses ( 0 . 2 2 mg kg ( 1 ) ) of noradrenaline and adrenaline dose dependently induced hepatic c fos and c jun mRNA levels . ^^^ The time course study showed that there was an increase in c fos and c jun mRNA levels within 15 min , which reached a peak at 30 min , and returned to the basal levels 1 2 h after noradrenaline or adrenaline injection ( 2 mg kg ( 1 ) , i . p . ) . ^^^ Noradrenaline ( 2 mg kg ( 1 ) , i . p . ) induced increases in c fos and c jun mRNA expressions were inhibited by the pre treatment with prazosin ( alpha 1 adrenergic antagonist ; 0 . 5 mg kg ( 1 ) , i . p . ) , but not with yohimbine ( alpha 2 adrenoceptor antagonist ; 1 mg kg ( 1 ) , i . p . ) nor with propranolol ( beta adrenoceptor antagonist ; 10 mg kg ( 1 ) , i . p . ) . ^^^ Adrenaline ( 2 mg kg ( 1 ) , i . p . ) induced increases in c fos and c jun mRNA expressions were inhibited by the pre treatment with prazosin or with propranolol , but not with yohimbine . ^^^ Administration of ICI 118 , 551 ( beta 2 adrenoceptor antagonist ; 2 mg kg ( 1 ) , i . p . ) , but not betaxolol ( beta 1 adrenoceptor antagonist ; 2 mg kg ( 1 ) , i . p . ) , blocked adrenaline ( 2 mg kg ( 1 ) , i . p . ) induced increases in c fos and c jun mRNA expressions . 4 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Extracellular H+ stimulates the expression of c fos / c jun mRNA through Ca2+ / calmodulin in PC 12 cells . ^^^ Evidence has accumulated that an increase in extracellular protons stimulates the transmembrane mechanism to induce various intracellular responses , such as the expression of c fos and c jun . ^^^ In the present study , we aimed to obtain evidence that an increase in extracellular protons induces expression of c fos / c jun mRNA in PC 12 pheochromocytoma cells of rats . ^^^ We found that the c fos / c jun mRNA expression increased when extracellular pH was decreased gradually from 7 . 40 to 7 . 20 and that there was a significant correlation between extracellular pH values and the expression of c fos / c jun mRNA . ^^^ To determine whether the Ca2+ / calmodulin system subserves the H+ induced expression of c fos / c jun , Ca2+ / calmodulin inhibitor trifluoperazine was added to PC 12 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , gel mobility shift analysis showed that cardiac JNK activation was followed by increased activator protein 1 DNA binding activity due to c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcript levels for the NF kappaB inhibitor IkappaBalpha and for the activating protein 1 constituents c jun and c fos also increased in response to HA stimulation of tubular cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift experiments further revealed dramatic changes in the proteins comprising the AP 1 complexes , including recruitment of the transcriptional activators c Fos , a novel Fos protein , Fos B , and Jun D . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The major components of transcription factor AP 1 ( Activator Protein 1 ) are encoded by the two families of genes related to the proto oncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Concomitantly , as investigated by RT PCR analysis , the transcriptional activity of c fos and c jun was stimulated , without altering mRNA expression of the myelin specific genes MBP , MAG , and PLP . ^^^ Thus , oxidative stress in oligodendrocytes leads to the onset of programmed cell death , involving the transcriptional activation of the immediate early genes c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we provide further evidence that the induction of junB , c jun , and c fos genes is due to active viral macromolecular synthesis rather than to the interaction of EV 1 with its receptor , alpha2beta1 integrin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis showed that glutathione depletion markedly or completely suppressed the diamide induced expression of c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we investigated the involvement of the actin cytoskeleton in propagation of insulin signaling events leading to DNA synthesis and expression of the immediate early genes c fos and c jun in L 6 muscle cells . ^^^ Insulin reorganized the cellular actin network and increased the rate of DNA synthesis and the levels of c fos mRNA , but not those of c jun mRNA , in undifferentiated L 6 myoblasts . ^^^ Similarly , insulin markedly elevated the levels of c fos mRNA but not of c jun mRNA in differentiated L 6 myotubes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A heterogenous group of compounds , that stimulated the expression of c fos / c jun , enhanced the nuclear binding activity of AP 1 . ^^^ In cotransfection experiments , overexpression of c Jun and c Fos reduced promoter activity of a 7 kb DNA fragment of the 5 ' flanking sequence of the human NOS 2 gene to 63 % . 4 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Work in our laboratory revealed an essential role of the immediate early gene product c Fos in light induced apoptosis . c Fos is a member of the AP 1 family of transcription factors and , together with other members of this family , it may regulate apoptosis in the central nervous system . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One protected region , common to both fibroblasts and monocytes , spans a putative phorbol ester responsive element ( TRE ) , and binding to the TRE by AP 1 was verified with antibodies directed against c fos and c jun family members . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The temporospatial cellular reactions were assessed by terminal deoxynucleotidyltransferase mediated dUTP biotin nick end labeling ( TUNEL ) staining of DNA fragments , in situ hybridization ( heat shock protein hsp 70 ; immediate early genes c fos and c jun ) , and immunocytochemical ( HSP 70 ; and myeloperoxidase , specific marker of polymorphonuclear leukocytes [ PMNL ] ) techniques . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Linoleic acid induced early growth response events , such as activation of ERKs , induction of expression of c fos and jun B and stimulation of AP 1 activity , however , were not affected by cAMP . ^^^ In contrast , linoleic acid induced c jun expression was blocked by cAMP . cAMP alone stimulated ERKs activation , c fos and jun B expression and increased AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BACKGROUND AND OBJECTIVES : To further analyze the neonatal immune response to an antigenic challenge such as blood transfusion , c fos and c jun mRNA expression were analyzed in twelve in vitro stimulated normal cord blood and ten in vitro stimulated normal adult peripheral blood lymphocyte samples . ^^^ In addition , Northern blot analysis of cord and adult samples revealed similar maximal increases in c fos ( 99+ / 15 and 126+ / 11 % , p = 0 . 0126 ) and c jun ( 123+ / 9 and 185+ / 38 % , p = 0 . 0291 ) mRNA expression , respectively , as early as 15 min post alphaCD 3 stimulation . ^^^ Adult lymphocytes showed an equivalent increase in mRNA expression of c fos and c jun ( 140+ / 25 and 155+ / 31 % ) at 30 min post PHA stimulation , while cord lymphocyte maximum c fos and c jun expression ( 82+ / 6 and 142+ / 12 % ) occurred at 15 min post PHA stimulation ( c fos , p = 0 . 0354 ; c jun , p = 0 . 0112 ) . ^^^ CONCLUSION : Although cord lymphocyte proliferation rates were significantly greater than those of adult lymphocytes following stimulation , lymphocyte activation , as analyzed by c fos and c jun mRNA expression , appears similar in both cord and adult samples . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of the cells to the Ca2+ ionophore A 23187 led to a rapid transient rise in egr 1 and c fos mRNA production followed by an increase in Egr 1 and c Fos protein levels as well as an increase in Egr 1 and activator protein 1 ( AP 1 ) DNA binding activity . ^^^ In contrast , treatment with cyclosporin A , which inhibits the Ca2+ / calmodulin dependent protein phosphatase 2B or calcineurin , increased both egr 1 and c fos mRNA production and the DNA binding activity of the Egr 1 and AP 1 transcription factors in response to the intracellular Ca+ concentration ( [ Ca2+ ] 1 ) increasing agents A 23187 or cyclopiazonic acid . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We showed that serum deprivation and etoposide induced a distinct pattern of regulation of c Fos , c Jun and p 53 protein levels , as well as the differential changes in DNA binding activity of AP 1 and NF kappaB transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of prolactin on expression of the mRNAs encoding the immediate early genes zif / 268 ( NGF 1 A ) , nur / 77 ( NGF 1 B ) , c fos and c jun in the hypothalamus . ^^^ In the present study , quantitative in situ hybridization histochemistry ( ISHH ) was used to visualize the induction of mRNAs for four different IEGs : zif / 268 ( NGF 1 A ) , nur / 77 ( NGF 1 B ) , c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gonadotropin releasing hormone ( GnRH ) gene regulation by N methyl D aspartic acid in GT 1 1 neuronal cells : differential involvement of c fos and c jun protooncogenes . ^^^ Since NMDA ( 100 microM ) and SNP ( 1 microM ) markedly induced c jun expression , but not c fos expression , we hypothesized that Jun activation is responsible for the transcriptional activation of GnRH gene expression . ^^^ Moreover , overexpression of c jun induced GnRH promoter activity , while c fos overexpression decreased GnRH promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In ICIG 7 cells , IL 4 triggers the tyrosine phosphorylation of at least two proteins ( 110 and 180 kDa ) , and up regulates the transcription of c fos , c jun and c myc proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BACKGROUND : Activated c fos binds to jun proteins to form the activation protein 1 ( AP 1 ) transcription factor that regulates cytokine and other proinflammatory genes . c Fos may play a key role in nasal polyp formation . ^^^ CONCLUSION : Glucocorticoids appear to modulate expression of c fos irm and possibly AP 1 in human airway epithelial cells in vivo . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nonobligate role of early or sustained expression of immediate early gene proteins c fos , c jun , and Zif / 268 in hippocampal mossy fiber sprouting . ^^^ The cellular immediate early genes ( IEGs ) c fos , c jun , and zif / 268 are major candidates for the initial steps of this plasticity , because they encode transcription factors that may trigger cascades of activity dependent neuronal gene expression and are strongly induced in all experimental models of MF sprouting . ^^^ Here we report that stargazer mice show no detectable elevations in c Fos , c Jun , or Zif / 268 immediate early gene proteins ( IEGPs ) before or during MF growth . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Manganese induced apoptosis is accompanied by the induction of DNA fragmentation , expressions of c Fos and c Jun , and activation of the c Jun N terminal kinase U ( JNK ) pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dexamethasone also elicited suppression of the AP 1 family of nuclear binding proteins , but with a slower time course than seen for c fos induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NF kappaB ( p 50 and p 65 ) , AP 1 ( c Fos and c Jun ) , E2F 1 , E2F 4 , MyoD , and myogenin ) . p 202 modulates the transcriptional activity of these factors in transfected cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Spontaneous expression of bcl 2 , bax , c myc . c fos , c jun , p 53 , Fas and tumour necrosis factor ( TNF ) alpha by bone marrow cells was measured using either semiquantitative or quantitative reverse transcription polymerase chain reaction in SLE patients ( n = 8 ) and in eight normal control subjects . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
UVB irradiation induced activator protein 1 activation correlates with increased c fos gene expression in a human keratinocyte cell line . ^^^ UVB irradiation significantly increased luciferase activity in these stably transfected cells , with maximum activity observed at 24 h after UVB irradiation . c Fos and Jun D were identified by antibody clearing assays as the main components of the bound AP 1 complexes . ^^^ Northern and Western analyses revealed a correlation between increased AP 1 activity and accumulation of c fos mRNA and c Fos protein after UVB irradiation . ^^^ These results suggest that increased c fos expression may play an important role in UVB induced AP 1 activation in HaCaT cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BACKGROUND : We examined the immunolocalization of proto oncogene products , including c Fos and c Jun , in the rat cornea during epithelial and stromal wound healing after simple epithelial ablation , penetrating injury or alkali burn . ^^^ RESULTS : c Fos and c Jun immunoreactive cells were detected in the epithelium around the epithelial defect from 60 to 120 min after these treatments . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of AT 1 receptors is associated with endothelial dysfunction , mainly as the consequence of an increased vascular production of superoxide radicals , vasoconstriction , platelet activation , enhanced release of plasminogen activator inhibitor 1 , activation of immediate early genes c fos and c jun , myocyte hypertrophy , connective tissue formation , endothelin 1 synthesis , and activation of growth factors like PDGF and TGF beta 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Experiments in transgenic mice overexpressing c Fos ( H 2 c fos ) showed reconstituted AP 1 DNA binding . ^^^ Analysis of Fos and Jun protein levels revealed no major differences in the expression of Jun proteins , but a marked decrease in c Fos in anergic T cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C Fos , Jun D and HSP 72 immunoreactivity , and neuronal injury following lithium pilocarpine induced status epilepticus in immature and adult rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Insulin stimulates cellular oncogenic activators such as c jun , c fos , and c myc ; and hepatitis B virus ( HBV ) 10 , a viral transactivator , is known to induce liver cancer in transgenic mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Apoptotic cell death was shown to be accompanied or preceded by an elevated expression of the c fos protooncogene and DNA binding activity of transcription factor AP 1 . ^^^ After castration an AP 1 complex accumulated in the prostate of Fos deficient mice which mainly consists of FosB , Fra 2 and JunD whereas in control animals the AP 1 complex in addition contained c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Kinase activation is followed by an increase in c fos and c jun gene expression and enhanced transcription factor AP 1 DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A transformed phenotype of uterine endometrial cancers is supported by estrogen dependent oncogene ( c Ha ras , c fos and c jun ) expressions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of cytochrome P450IA1 ( P450IA1 ) mRNA and protein expression was observed in both liver and kidney slices . c fos and c Ha ras gene expression was enhanced in liver , but not kidney , slices by BaP . c jun mRNA levels were decreased in liver and kidney slices , although the effect was earlier ( 0 . 5 h ) in liver slices compared to kidney slices . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We test whether these abnormalities are associated with excessive generation of c fos , the inducible component of AP 1 . ^^^ We suggest that increased c fos synthesis provides a major mechanism for the increased AP 1 and decreased GR DNA binding seen in CR asthma . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Pre drug cues modulate morphine tolerance , striatal c Fos , and AP 1 DNA binding . ^^^ To evaluate the molecular mechanisms that mediate the effect of learning on morphine tolerance in rats , we examined striatal c Fos , and c Jun protein expression , and AP 1 DNA binding . ^^^ Striatal c Fos protein levels and AP 1 DNA binding activity were increased in rats receiving paired morphine compared with rats that did not receive morphine but not in rats receiving morphine without the CS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have examined the expression of members of the AP 1 transcription factor complex in response to stimulation with different doses of LPA . c Fos , c Jun , and JunB are induced rapidly in response to LPA stimulation , whereas Fra 1 and Fra 2 are induced after a significant lag . ^^^ The expression of c Fos is transient , whereas the expression of c Jun , JunB , Fra 1 , and Fra 2 is sustained . ^^^ LPA stimulated expression of c Fos , Fra 1 , Fra 2 , c Jun , and JunB is inhibited by the MEK 1 inhibitor PD 098059 , indicating that the Raf MEK MAPK cascade is required for their expression . ^^^ In cells expressing a conditionally active form of Raf 1 ( DeltaRaf 1 : ER ) , we observed that selective , sustained activation of Raf MEK MAPK was sufficient to induce expression of Fra 1 , Fra 2 , and JunB but , interestingly , induced little or no c Fos or c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the question whether this stop of DNA synthesis is due to a decline of the synthesis of proteins that are necessary for G 1 progression and S phase entry , we examined the expression of two proto oncogenes ( c fos , c jun ) and three cyclins ( D 1 , E , A ) after altering the microfilament system . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our studies on the distal region of the promoter in U87MG cells identify a negative cis element ( 1377 / 1298 ) which contains a AP 1 like site able to bind c jun and c fos transcription factors , according to the results of DNA / protein binding assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This c Jun activity is inhibited by c Fos , another protooncoprotein that can dimerize with c Jun to form the transcription factor AP 1 . ^^^ Here we show that c jun mediates hAR induced transactivation from the promoter of the androgen regulated gene , human kallikrein 2 ( hKLK 2 ) , and c Fos blocks this activity . ^^^ Using c Fos truncation mutants and measuring hKLK 2 dependent transcription , we have determined that the bZIP region of c Fos is required and sufficient for inhibiting c Jun enhancement of hAR transactivation . ^^^ These results suggest that heterodimerization by c Fos with c Jun blocks c Jun ' s ability to enhance hAR induced transactivation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CONCLUSIONS : Colocalization of Nrl and c Fos suggests that expression of rod specific genes , which utilize AP 1 or NRE sites in their promoter , could be regulated through the formation of Nrl Fos dimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Birth related expression of c fos , c jun and substance P mRNAs in the rat brainstem and pia mater : possible relationship to changes in central chemosensitivity . ^^^ Levels of mRNA corresponding to the immediate early genes ( IEG ) , c fos and c jun , and of substance P precursor , ppt A , were determined in rat fetuses ( E 21 ) and neonatal pups ( 1 h , 1 day and 6 days after normal birth ) and after exposure to hypercapnia ( 12 % CO 2 for 1 h ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our objective was to assess the reproducibility of the 60 Hz magnetic field induced , time dependent transcription changes of c fos , c jun and c myc oncogenes in CEM CM 3 cells reported by Phillips et al . ( Biochim . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In northern blot analysis of gossypol treated cells , there was a dose dependent increase in c fos , a component of the redox regulated transcription factor activator protein 1 ( AP 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Quantitative neuronal c fos and c jun expression in Alzheimer ' s disease . ^^^ Activation of immediate early genes ( IEG ) c jun and c fos appears to be required for the initiation of apoptosis . ^^^ Using immunohistochemical methods , we calculated the average number of neuronal profiles per unit area expressing c Jun and c Fos within hippocampal regions CA 1 , CA2 / 3 , and CA 4 in postmortem brain samples from AD patients and age matched non AD patients . ^^^ There was an increase in c Jun positive and c Fos positive neuronal profile density in nearly all AD hippocampal regions examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The most active compound identified was used to examine the role played by protein kinase C alpha in mediating the phorbol ester induced changes in c fos , c jun , and junB expression in A 549 lung epithelial cells . ^^^ Depletion of protein kinase C alpha protein expression by this oligonucleotide lead to a reduction in c jun expression but not c fos or junB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the latter condition , it was found that CREM messenger RNA reached its highest levels at 6 h , i . e . later than the maximal increase of expression of immediate early genes such as c fos , jun B and zif 268 , observed 45 min following the onset of visual stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transformed focal cells were used in in vitro studies including anchorage independent analysis , focal reconstruction , gene transfection using NIH 3T3 host cells , and Southern blotting to assess amplification of five proto oncogenes ( K ras , H ras , c fos , c jun , c myc ) and a tumor suppressor ( p 53 ) gene . ^^^ Results showed that 1 ) there was a significant increase in anchorage independent growth of all five types of foci ranging from 7 12 % ; 2 ) all five morphological types of transformed foci showed 8 15 % focal reconstruction ; 3 ) DNA from all five types of transformed foci induced transformation in NIH 3T3 cells at a level significantly above the control DNA ; 4 ) gene amplification studies indicated amplification in both K ras and H ras proto oncogenes ; however , c fos , c jun , and c myc did not show DNA amplification . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In response to oxidant stress , the cardiovascular system is known to express a number of genes , which could occur owing to the participation of mitogen activated protein kinases such as MAPKs , ERK and JNK ( SAPK ) followed by stimulation of at least two well defined transcription factors NF KB and AP 1 ( c Fos and c Jun ) . ^^^ TNF alpha , on the other hand , induces c fos , c myc and c jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These include morphogens , such as angiotensin 2 derived from an intraadrenal origin , growth factors , for example insulin like growth factor 1 , which can be considered to be the paracrine amplifiers of the morphogenic signal and finally transcription factors , such as c fos and c jun , that directly stimulate mitosis and other events of differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The stimulation of the zona glomerulosa phenotype by a low sodium diet is characterised by increased expression of aldosterone synthase accompanied by increases in ( pro ) renin , bFGF , c fos and c jun gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of genes for retinoic acid receptors ( RARs ) and activator protein 1 ( encoded by the c Jun and c Fos genes ) in lung tissue specimens was examined by western blotting . ^^^ Ferrets given a beta carotene supplement and exposed to tobacco smoke had threefold to fourfold elevated expression of the c Jun and c Fos genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ARE contains AP 1 and AP 1 like elements and is known to bind to several leucine zipper proteins including c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis identified CREB 1 , JunB , c Fos , Fra 1 , and c Jun in protein complexes isolated from differentiated rabbit tracheal epithelial cells binding to this site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The [ Ca2+ ] 1 signal was required for the transcriptional activation of two immediate early genes ( IEGs ) , c fos and c jun , since blocking Ca2+ influx with Gd3+ or EGTA reduced IEG transcription , while augmenting Ca2+ influx increased IEG transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This decline results from a PKC dependent decrease in the relative expression of c Jun , an activator of Cdx 2 transcription , compared to c Fos , an inhibitor of Cdx 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We used complementary genetic , biochemical and molecular approaches to demonstrate that : ( 1 ) phosphatidylinositol 3 kinase signaling is the principle mechanism of polyoma virus middle T oncoprotein activation of c fos expression ; ( 2 ) middle T / phosphatidylinositol 3 kinase transactivation of the c fos promoter and transformation of cells requires activation of both the small GTP binding protein Rac and Jun N terminal kinase ; ( 3 ) retinoic acid inhibits activation of Jun N terminal kinase , thereby preventing c fos transactivation and transformation ; and ( 4 ) middle T activation of c fos transcription requires both the serum response element and the promoter proximal cyclic AMP response element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos , c jun , and c jun N terminal kinase ( JNK ) in a developmental model of induced apoptotic death in neurons of the substantia nigra . ^^^ The transcription factors c fos and c jun have been proposed to play a role in the initiation of programmed cell death in neurons . ^^^ We have investigated the relationship between c fos and c jun protein expression and induced death in neurons of the SN . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Under light stimulation , c Fos and Jun B consistently increased , as expected , but this was also the case for Fra 2 , Jun D , and c Jun , although to a lesser extent . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoelectron microscopic study of c Fos , c Jun and heat shock protein after transient cerebral ischemia in gerbils . ^^^ Using immunoelectron microscopy , we examined the ultrastructural integrity of the neurons with expression of c Fos , c Jun and HSP 70 in gerbils after transient cerebral ischemia and reperfusion . ^^^ Induction of c Fos and c Jun was observed in the CA 3 region resistant to ischemia , while HSP 70 was expressed not only in the CA 3 but also in the vulnerable CAI region . ^^^ With immunoelectron microscopy , the expression of c Fos / c Jun and HSP 70 was observed in the neurons which retained neuronal integrity except for mitochondrial swelling and polyribosomal disaggregation . ^^^ These findings suggested that c Fos and c Jun were induced selectively in reversibly damaged neurons , whereas HSP 70 was up regulated even in neurons with irreversible damage , but was more preferentially and intensely expressed in neurons with reversible damage . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factors c Jun , c Fos and c Myc were found associated with apoptosis in retinal cells , but their sub cellular location in apoptotic bodies is not consistent with their canonical functions in the control of gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The products of c fos and c jun are components of the transcription factor AP 1 ( activator protein 1 ) . 12 O Tetradecanoylphorbol 13 acetate ( TPA ) , a known AP 1 agonist , induced ERCC 1 mRNA to the same extent as cisplatin , but did not synergize with cisplatin in this regard . ^^^ Cyclosporin A and herbimycin A , which suppress c fos and c jun gene expressions , respectively , blocked the cisplatin induced increase in ERCC 1 mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine nuclear proto oncogene changes mediating these events , c myc , c fos , c jun and junB were measured in spontaneously differentiating cells and in cells exposed to EGF . c myc showed a transient rise in expression at 4 8 h with augmented expression by EGF , occurring even in the absence of serum or attachment . c myc and c jun declined during culture , but c fos and particularly junB showed increased expression by day 3 with marked responses to EGF stimulation . ^^^ Syncytia induced to form by EGF exposure for 48 h demonstrated marked junB expression after rechallenge with 40 min EGF exposure , but negligible responses of c fos and c jun . c myc showed increased expression after 6 h EGF exposure throughout the culture period and in syncytia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There were significant increases in JunD mRNA and protein in DFMO treated cells , although expression of the c fos , c jun , and junB genes decreased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TrkC mediated NT 3 signaling promotes apoptosis by activating multiple parallel signaling pathways and by inducing immediate early gene expression of both c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ligand activated retinoic acid receptor inhibits AP 1 transactivation by disrupting c Jun / c Fos dimerization . ^^^ AP 1 is a dimeric complex of the protooncoproteins c Jun and c Fos and directly regulates transcription of genes important for cellular growth . ^^^ Our data argue for a novel mechanism by which RARs can repress AP 1 DNA binding , in which liganded RARs are able to interfere with c Jun / c Jun homodimerization and c Jun / c Fos heterodimerization and , in this way , may prevent the formation of AP 1 complexes capable of DNA binding . . ^^^ AP 1 is a dimeric complex of the protooncoproteins c Jun and c Fos and directly regulates transcription of genes important for cellular growth . ^^^ Using a mammalian two hybrid system , we report here that human RARalpha ( hRARalpha ) can disrupt in a RA dependent manner the homo and heterodimerization properties of c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Signal transduction pathways involved in the activation of NF kappa B , AP 1 , and c fos by Mycoplasma fermentans membrane lipoproteins in macrophages . ^^^ LAMPf was capable of inducing NF kappa B , activated protein 1 ( AP 1 ) , and c fos activation in macrophages and of stimulating NF kappa B and AP 1 transactivation . ^^^ Furthermore , we have delineated the contribution of each mitogen activated protein kinase pathway to the LAMPf mediated activation of AP 1 , c fos , and NF kappa B . ^^^ Whereas the selective extracellular signal regulated kinase pathway inhibitor PD 98059 did not affect the LAMPf mediated transactivation of AP 1 , c fos , or NF kappa B , the specific p 38 inhibitor SB 203580 abrogated this activity . ^^^ A c Jun N terminal kinase dominant negative was shown to block the activation of AP 1 without altering NF kappa B or c fos activation by LAMPf . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous work has shown induction of c fos in response to application of mechanical strain to MCs , which may induce increases in AP 1 transcription factor activity , which , in turn , may augment ECM protein and transforming growth factor beta transcription and cell proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Many substrates of the calpain isoenzymes , such as the transcription factors c Fos and c Jun , the tumor supressor protein p 53 , protein kinase C , pp60c src and the adhesion molecule integrin , have been implicated in the pathogenesis of different human tumors , suggesting an important role of the calpains in malignant diseases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with our observation that AP 1 binding does not contribute to c Jun coactivation is the observation that the activation of PU . 1 by c Jun is blocked by overexpression of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
SP A elicited new transcription of surfactant proteins SP A , SP B , and SP C and SPAR and c Jun but had no effect on beta actin or c fos transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibody supershift assays indicated the presence of c Fos and JunB in the AP 1 complex formed in response to all three agonists . ^^^ In addition , cotransfection of VSMC with expression plasmids for c Fos and members of the Jun family along with the AP 1 dependent reporter gene revealed that AP 1 with c Fos and JunB composition exhibited a higher transactivating activity than AP 1 with other compositions tested . ^^^ Together , these results strongly suggest a role for redox sensitive mechanisms in agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation ; c Fos , c Jun , and JunB expression ; AP 1 activity ; and DNA synthesis in VSMC . ^^^ These results also suggest a role for NADH / NADPH oxidase activity in some subset of early signaling events such as p 38 MAP kinase activation and c Fos and JunB induction , which appear to be important in agonist induced AP 1 activity and DNA synthesis in VSMC . . ^^^ To understand the role of redox sensitive mechanisms in vascular smooth muscle cell ( VSMC ) growth , we have studied the effect of N acetylcysteine ( NAC ) , a thiol antioxidant , and diphenyleneiodonium ( DPI ) , a potent NADH / NADPH oxidase inhibitor , on serum , platelet derived growth factor BB , and thrombin induced ERK 2 , JNK 1 , and p 38 mitogen activated protein ( MAP ) kinase activation ; c Fos , c Jun , and JunB expression ; and DNA synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
HIV 1 gp 120 induces the activation of both c fos and c jun immediate early genes in HEL megakaryocytic cells . ^^^ Following the treatment of HEL cells with recombinant IIIB envelope gp 120 , we noticed : ( 1 ) increased levels of endogenous c fos and c jun mRNA and proteins , ( 2 ) activation of both c fos and c jun promoters , and ( 3 ) a very rapid stimulation of a MAPK / ERK pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 binding activity , consisting of c Jun , JunD , c Fos and Fra 2 proteins , was increased in Caco 2 cells at 3 days postconfluency , a time point associated with G 1 block and cessation of proliferation . ^^^ AP 1 binding activity , consisting of c Jun , JunD , c Fos and Fra 2 proteins , was increased in Caco 2 cells at 3 days postconfluency , a time point associated with G 1 block and cessation of proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using in vitro expressed human receptors , we now show that ER beta binds to a panel of six endogenous hormone response elements ( vitellogenin , c fos , c jun , pS 2 , cathepsin D , and choline acetyltransferase ) already known to bind ER alpha and confer estrogen inducibility to reporter constructs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blot studies showed that both c Fos and c Jun underwent similar transient inductions . ^^^ These temporal changes in c Fos and c Jun activities were unexpected because TIMP 1 mRNA expression is not detected in HSCs until culture day 3 to 5 and is thereafter sustained at a high level . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Other immediate early response genes , c fos and junB , were also induced following glucose stimulation with kinetics similar to egr 1 , whereas c jun and junD expression were not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemical studies of IEG expression performed at 3 h exhibited a marked induction of c Fos , c Jun , and Krox 24 protein in all sectors of the hippocampus , peaking in vulnerable CA 1 pyramidal neurons and in dentate gyrus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of p 38 MAPK and an activated form of MAPK kinase 6 resulted in activation of c jun and c fos reporter genes , but did not alter the expression of the glycoprotein hormone alpha subunit reporter . ^^^ Inhibition of p 38 activity with SB 203580 resulted in attenuation of GnRH induced c fos reporter gene expression , but was not sufficient to reduce GnRH induced c jun or glycoprotein hormone alpha subunit promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , on treatment with NGF , Trk A is phosphorylated and early responsive genes such as NGFI A , c fos and c jun are induced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our previous studies have indicated that UVB induced c fos expression may play a key role in UVB induced activation of the activator protein 1 transcription factor and EGCG inhibited , UVB induced activation of AP 1 in HaCaT cells . ^^^ Because AP 1 is important for tumor promotion and c fos is a major component of AP 1 , the inhibitory effects of EGCG on c fos expression may further explain the anti tumor promoting effects of EGCG . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recent studies have demonstrated that chronic alcohol intake can reduce hepatic retinoic acid concentrations , diminish retinoid signaling , and enhance activator protein 1 ( AP 1 ( c Jun and c Fos ) ) expression in rat liver . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF kappaB components p 50 and p 65 , and did not contain other NF kappaB proteins ( p 52 , c Rel , Rel B ) , AP 1 proteins ( c Fos , C Jun ) , CREB or C / EBPbeta ( NF IL 6 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , an assessment of fibroblast and HaCaT c fos and c jun gene expression after exposure to EGF and PMA showed that although both agonists increased the expression of c fos and c jun mRNA in fibroblasts , only EGF did so in HaCaT keratinocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression pattern of c fos , c jun , c kit and stem cell factor ( SCF ) has been investigated in developing human placenta using the highly sensitive technique of in situ reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ Specific transcripts of all genes under study were observed in first trimester placenta sections . c fos , c jun , c kit and SCF transcripts were localized in cells of the villous stroma ; fos , jun and kit specific mRNAs were also found in endothelial cells ; fos , kit and SCF mRNAs were detected in villous trophoblast cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of neurons in the inferior mesenteric ganglion ( IMG ) was assessed using c fos , JunB , and c Jun expression in the guinea pig IMG and colonic myenteric plexus during mechanosensory stimulation and acute colitis in normal and capsaicin treated animals . ^^^ Lower doses of capsaicin or vehicle were used to activate primary afferent fibers during balloon passage . c Jun did not respond to any of the stimuli in the study . c fos and JunB were absent from the IMG and myenteric plexus of untreated and saline treated animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Especially the AP 1 proteins have found increasing interest , since members of these families such as c Fos and c Jun seem to be involved in trophic changes in peripheral organs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Lipopolysaccharide activated AP 1 consisted of c Fos , Jun B , Jun D , and c Jun , while C 2 ceramide induced Jun D and c Jun only . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the studies reported herein , electrophoretic mobility shift assay ( EMSA ) and immunocytochemistry have been applied to document increased levels of AP 1 transcription factor , and its major component , c Fos in the rat brain following behavioral training of two way active avoidance . ^^^ Supershift EMSA analysis with antibodies directed at individual AP 1 components revealed that AP 1 extracted from the brains of trained as well as naive animals is composed of the same proteins , i . e . , in order of relative level within the protein family : c Fos , Fos B , Fra 2 , and Jun D , Jun B , c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential induction of c Fos , c Jun and Jun B in the rat central nervous system following unilateral entorhinal cortex lesion . ^^^ In order to identify some of the molecular mechanisms that occur after a central nervous system trauma , the immediate early gene encoded proteins c Fos , c Jun and Jun B were analysed by immunocytochemistry following unilateral entorhinal cortex lesion ( controls , 30 min , 2 , 5 , 12 and 24 h , two , six , 10 and 14 days , four weeks and six months postlesion ) . ^^^ In the lateral septal area , c Fos and c Jun were induced 30 min postlesion and decreased rapidly thereafter . ^^^ In the cerebral cortex , a widespread induction of c Fos and c Jun occurred within 30 min after entorhinal cortex lesion and this up regulation lasted until two days postlesion . ^^^ These data indicate that electrolytic lesion of the entorhinal cortex leads to a rapid and widespread induction of c Fos , c Jun and Jun B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of mechanical strain on transcription and expression of the immediate early genes , early growth response gene 1 ( Egr 1 ) , c jun , and c fos , was investigated in neonatal rat aortic vascular smooth muscle ( VSM ) cells . ^^^ Egr 1 mRNA increased rapidly in response to cyclic strain , reached a maximum of 10 fold after 30 minutes , and returned to baseline after 4 hours . c jun exhibited a similar pattern , whereas c fos mRNA expression was unaffected by strain . ^^^ These observations indicate that Egr 1 expression and translocation are sensitive to mechanical perturbation of the cell . c jun is also induced by strain , but c fos is not . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
H2O2 preferentially induced the expression of c fos , c jun , c myc and egr 1 , while JunB and JunD levels remained almost unchanged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the second experiment , following the administration of rhGH ( 8 mg / kg b . wt . ) bone osteocalcin mRNA increased by 127 , 177 , 361 , and 413 % over the control level at 30 min , 1 h , 2 h and 4 h , respectively ; IGF 1 mRNAs increased by 38 , 33 , 87 , and 437 at 30 min , 1 h , 2 h and 4 h , respectively , but the levels did not become significant until 2 h ; c fos mRNA increased significantly at 30 min , and c jun and c myc mRNAs did not increase until 4 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos , junB , c jun , MKP 1 and hsp 72 following traumatic neocortical lesions in rats relation to spreading depression . ^^^ The effects of a traumatic neocortical lesion on c fos , junB , c jun , MKP 1 and hsp 72 expression were examined by in situ hybridization and immunocytochemistry 1 6 h following transcranial cold injury . ^^^ In animals without spreading depressions , only a short lasting response of c fos , junB , c jun and MKP 1 messenger RNAs as well as c Fos protein was bilaterally found in the piriform cortex , and with ipsilateral dominance the dentate gyrus and hippocampal CA3 / 4 fields at 1 h after lesioning . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fra 1 potentiates osteoclastic differentiation in osteoclast macrophage precursor cell lines . c Fos , a component of the dimeric transcription factor AP 1 , is necessary for osteoclast formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also assessed the effects of estradiol on the steady state level of c fos and c jun mRNA and on the binding of mesangial cell nuclear extracts to an AP 1 consensus binding site oligonucleotide . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of the expression of the nerve growth factor ( NGF ) gene has been reported previously to be mediated by the interaction of c fos with an activator protein 1 ( AP 1 ) binding site present in the first intron on the NGF gene . ^^^ Our previous studies have shown that haloperidol and ( ) sulpiride induce the expression of c fos and c jun mRNAs and increase their AP 1 DNA binding activities . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of HMG CoA reductase inhibition on PDGF and angiotensin 2 mediated signal transduction : suppression of c Jun and c Fos in human smooth muscle cells in vitro . ^^^ In this study it was investigated whether HMG CoA reductase inhibition could affect induction of the transcription factors c Jun and c Fos in smooth muscle cells , which play an important role in atherogenesis . ^^^ Stimulation in the absence of the HMG CoA reductase inhibitor led to a significant induction of c Jun and c Fos . ^^^ Concomitant addition of mevalonate , farnesylpyrophosphate and geranylgeranylpyrophosphate prevented the effects of HMG CoA reductase inhibition resulting in rescued expression of c Jun and c Fos . ^^^ The data demonstrate that lovastatin can suppress PDGF and angiotensin 2 mediated induction of c Jun and c Fos protein in human SMC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The introduction of a dominant negative version of c Jun into ras transformed fibroblasts was able to rescue c fos gene induction in response to serum stimulation , further demonstrating that AP 1 is indeed involved in c fos gene repression . ^^^ Fra 1 containing AP 1 complexes repress the c fos and possibly other immediate early genes thereby preventing the induction of certain delayed early genes such as the T 1 gene in response to mitogenic stimulation . . ^^^ We provide evidence that Fra1 / c Jun heterodimers are responsible for the repression of c fos gene induction following serum stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In susceptible regions undergoing an apoptotic like death there was not only a prolonged induction of the immediate early genes , c jun , c fos and nur 77 , but also of possible target genes amyloid precursor protein ( APP 751 ) and CPP 32 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RNA expression studies , again based on a multiplexed nuclease protection assay , showed that TGF beta related genes were induced and temporally regulated during POH treatment : ( a ) c jun and c fos were transiently induced within 12 h of chemotherapy ; ( b ) TGF beta 1 was induced within 24 h of chemotherapy ; ( c ) the mannose 6 phosphate / insulin like growth factor 2 receptor and the TGF beta type 1 and 2 receptors were induced within 48 h of chemotherapy ; and ( d ) smad 3 was induced during active carcinoma regression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CREB binding protein ( CBP ) and the closely related adenovirus E1A associated 300 kD protein ( p 300 ) function as coactivators of transcription factors such as CREB , c Fos , c Jun , c Myb , and several nuclear receptors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After portal branch ligation in rat , nuclear factor kappaB , interleukin 6 , signal transducers and activators of transcription 3 , c fos , c myc , and c jun are similarly induced in the ligated and nonligated lobes . ^^^ To assess whether these events do specifically occur in a cellular system undergoing regeneration , we studied the induction of nuclear factor kappaB ( NFkappaB ) , interleukin 6 ( IL 6 ) , signal transducers and activators of transcription 3 ( Stat 3 ) , c fos , c myc , c jun , after portal branch ligation ( PBL ) , which produces atrophy of the deprived lobes ( 70 % of the liver parenchyma ) , whereas the perfused lobes undergo compensatory regeneration . ^^^ IL 6 was elevated in both lobes from 1 to 8 hours after PBL as well as c fos , c myc , and c jun during the first 2 hours . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The analyses of the cell cycle and nuclear transcription factor activities revealed that TNF alpha treatment caused the Ha ras overexpressed transformants to shift from S to G0 / G1 phase and increased the responses of AP 1 , c fos , and c myc . ^^^ Taken together , we suggest that the possible action of Ha ras overexpression to sensitize TNF alpha treated fibroblasts is predominantly through the Ras / Raf 1 / MAPK pathway to increase the responses of AP 1 , c fos , and c myc , which are possibly involved in the aberration of cell cycle machinery , and subsequently to turn on the death program . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of mild traumatic brain injury on immunoreactivity for the inducible transcription factors c Fos , c Jun , JunB , and Krox 24 in cerebral regions associated with conditioned fear responding . ^^^ In the present study , we examined the expression patterns of immunoreactivity ( IR ) for four ITFs ( c Fos , c Jun , JunB , and Krox 24 ) at 3 h after mild fluid percussion TBI . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Within the cell the tumor suppressor gene p 53 and oncogenes c myc , c fos and c jun tend to activate apoptosis , while other genes such as most members of the bcl 2 family , tend to suppress it . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The actions of IGF 1 are associated with the generation of lipidic messengers and the activation of Raf kinase , which results in the rapid induction of the expression of the proliferative cell nuclear antigen ( PCNA ) and the nuclear proto oncogenes c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays of nuclear extracts from TPA treated cells revealed an increase in DNA binding activity specific for the AP 1 like binding site in the 5 ' flanking region of ERCC 1 . c Jun and c Fos proteins were confirmed to be the components of the activated AP 1 complex by supershift analysis . ^^^ TPA stimulation of A2780 / CP70 cells also resulted in a rapid but transient induction of c jun and c fos as determined by Northern and Western blot analyses , which peaked about 2 h before the peak in ERCC 1 expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has been demonstrated that glucocorticoid receptors antagonize the actions of inflammatory mediators through control of the specific DNA binding of the transcriptions factors c Jun and c Fos , and also decrease the mRNA and protein levels of these two transcription factors in a number of in vivo and in vitro studies . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , a more direct approach , investigating expression of putative hibernation responsive genes by Northern analysis , revealed an increase in expression of transcription factors c fos , junB , and c Jun , but not junD , commencing during late torpor and peaking during the arousal phase of individual hibernation bouts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our results demonstrated that : ( 1 ) PGN induced phosphorylation of the transcription factors ATF 1 and CREB ; ( 2 ) ATF 1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid , which was inhibited by dominant negative CREB and ATF 1 ; ( 3 ) PGN induced phosphorylation of c Jun , protein synthesis of JunB and c Fos , and transcriptional activation of the AP 1 reporter plasmid , which was inhibited by dominant negative c Fos ; and ( 4 ) PGN induced activation of CREB / ATF and AP 1 was mediated through CD 14 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has been shown recently that 17beta estradiol ( E 2 ) can stimulate the Src / p21ras / mitogen activated protein kinase pathway in breast cancer cells , and this effect is supposed to mediate the E 2 induced stimulation of breast cancer cell proliferation , possibly via activation of the c fos and c jun early genes or of genes involved in cell cycle control . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After 2 h of aldosterone treatment , fra 2 mRNA was upregulated by 130 % , whereas c myc , c jun , c fos , and glucocorticoid receptor mRNAs were downregulated by 23 43 % . ^^^ After 16 h , c fos and GR mRNAs were further decreased , whereas levels of fra 2 , c jun , and c myc began to return to control levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Defective c Fos and FosB expression in cortical thymocytes is functionally significant , because antibody supershift experiments show that in activated immature and mature thymocytes , most detectable AP 1 DNA binding complexes do contain c Fos or FosB . ^^^ Thus , defective c Fos and FosB expression in cortical thymocytes qualitatively alters any AP 1 complexes they might express . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In rat cardiocytes ANG 2 also causes induction of many immediately early genes ( c fos , c jun , jun B , Egr 1 and c myc ) and induces also late markers of cardiac hypertrophy ( skeletal alpha actin and atrial natriuretic peptide expression ) and growth factors ( TGF beta 1 gene expression ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We focussed our analysis on c Fos ( typical of AP 1 genes which are expressed rapidly and transiently ) and Fra 1 and JunB ( typical of AP 1 genes expressed after a delay but in a sustained manner ) . ^^^ Thrombin stimulated a rapid but transient accumulation of c Fos whereas the expression of Fra 1 , Fra 2 , c Jun and JunB was sustained throughout the G 1 phase of the cell cycle . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using gene targeting , we examined HCT 116 cells that contain the Gly 13 > Asp mutation of Ki ras and activated Ki ras disrupted clones derived from HCT 116 . 12 O Tetradecanoylphorbol 13 acetate ( TPA ) induced immediate early genes , such as c Jun , c Fos , and Egr 1 in activated Ki ras disrupted clones , whereas c Jun induction was rare in HCT 116 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 motif in the human p 53 promoter binds c Fos and c Jun and the NF kappaB motif binds p 50 ( NF kappaB ) and p65RelA . ^^^ In addition , we show that ( a ) the level of endogenous p 53 mRNA and ( b ) transcription from the strictly p 53 dependent human mdm 2 promoter are reduced in the presence of c fos , c jun , p 50 ( NF kappaB 1 ) , p65RelA or c myc antisense oligonucleotides , underscoring the importance of these transcription factors for the expression of functional p53 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Message levels for c fos , jun B , and c jun were increased in the presence of hemolysate , reaching maximum expression between 30 and 60 minutes , whereas the level of jun D mRNA was unaffected . ^^^ Increasing doses of hemolysate caused greater expression of c fos and jun B , but not c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inducible transcription factors encoded by immediate early genes such as c fos , c jun , jun B and zif / 268 ( also known as krox 24 , egr 1 , TIS 8 , NGFI A or zenk ) are supposed to act as messengers in coupling short term neuronal activity with changes at the level of gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The early response genes , c Fos and c Jun , are induced by environmental stress and are thought to modulate injury processes via the induction of AP 1 dependent target genes . ^^^ Reverse transcriptase polymerase chain reaction analysis and immunoblotting demonstrated that c Fos and c Jun were induced 2 10 h following heat shock , and this induction was accompanied by an increase in AP 1 DNA binding . ^^^ These results indicate that heat shock activates c Fos / c Jun gene expression and AP 1 DNA binding and suggests that redox sensitive signal transduction pathways involving Ref 1 may mediate heat induced alterations in AP 1 activation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^ Conversely , c Fos , the canonical dimerization partner of Jun proteins is expressed in substantial quantity in HeLa and ' CGL3 ' cells , but it is completely absent in AP 1 complexes from non tumorigenic ' 444 ' cells . ^^^ AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^ Ectopical expression of c fos under a heterologous promoter in ' 444 ' cells induces tumorigenicity and a change of the Jun / Fra 1 ratio towards a constellation initially detected in ' CGL3 ' and HeLa cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In co transfection studies , the expression of c Jun plus c Fos enhanced the transactivation of oIFNtau CAT but the expression of GATA 1 , GATA 2 or GATA 3 did not . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Are there multiple proteolytic pathways contributing to c Fos , c Jun and p 53 protein degradation in vivo . ^^^ The c Fos and c Jun oncoproteins and the p 53 tumor suppressor protein are short lived transcription factors . ^^^ Several catabolic pathways contribute to their degradation in vivo . c Fos and c Jun are thus mostly degraded by the proteasome , but there is indirect evidence that , under certain experimental / physiological conditions , calpains participate in their destruction , at least to a limited extent . ^^^ Moreover , c Fos , c Jun and p 53 turnovers are regulated upon activation of intracellular signalling cascades . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos , c jun , jun b , jun d , srf and pc 4 mRNA was examined after partial optic nerve crush in the adult rat retina by in situ hybridization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We observed an increase in the amount of both c jun and c fos mRNA in cells with 12 , 65 , or 200 fold higher resistance to adriamycin when compared to drug sensitive MCF 7 wild type ( WT ) cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As judged by the reverse transcriptase polymerase chain reaction , resveratrol selectively inhibited TPA induced expression of c fos and transforming growth factor beta 1 ( TGF beta 1 ) , but did not affect other TPA induced gene products including COX 1 , COX 2 , c myc , c jun , and tumor necrosis factor alpha . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Independent from the induction of cell proliferation , but related to cell differentiation , the early and transitory chromatin dispersion as well as the influence of c fos related to proteic system activator ( AP 1 ) is discussed in referring to recent studies ( 1997 ) , as well as the regulation factors of the chromatin filament structure . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hepatic transcription of insulin like growth factor binding protein 1 ( IGFBP 1 ) is rapidly downregulated by growth hormone ( GH ) which is also known to induce expression of c fos and c jun . ^^^ Co expression of c fos or c jun in rat hepatocytes , individually or together , suppresses IGFBP 1 promoter activity by approximately 60 % . ^^^ When F 1 and F 2 were removed by deletion of the region from 824 to 557 bp , the GH response was lost but suppression by co expression of c fos and c jun was preserved . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Co transfection with expression vectors for p 65 ( RelA ) and the AP 1 subunits c Fos and c Jun resulted in a decrease in the stimulatory effect of PDTC on HIV 1 LTR activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TPA treatment also elevates the expression of cyclooxygenase 1 ( COX 1 ) , cyclooxygenase 2 ( COX 2 ) , c myc , c fos , c jun , transforming growth factor beta 1 ( TGF beta 1 ) and tumor necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous studies in our laboratory have shown that the mood stabilizers , lithium and valproate ( VPA ) , regulate the transcription factors , cyclic AMP responsive element binding protein ( CREB ) , c Fos and c Jun , differentially in cultured human neuroblastoma SH SY5Y cells . ^^^ We found that although chronic treatment with LiCl or VPA did not change the expression of c Fos and c Jun , acute treatment with either drugs increased c Fos expression but not c Jun expression in CA 1 and CA 3 regions of hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos and c jun in the paraventricular nucleus play a role in regulating peptide gene expression , oxytocin and glutamate release , and maternal behaviour . ^^^ We investigated the role of c fos dimerizing with c jun in controlling the induction of maternal behaviour , altered peptide gene expression , and oxytocin and amino acid release in this region at birth . ^^^ Fluorescence labelled antisense oligodeoxyribonucleotides ( ODNs ) against c fos / c jun were infused bilaterally in the PVN , via microdialysis probes with 100 kDa cut off membranes , and were incorporated into 50 60 % of the cells . ^^^ These results suggest that c fos / c jun transcription factors play a role in the birth induced upregulation of oxytocin , CRH and preproenkephalin gene expression , as well as on glutamate and oxytocin release in the sheep PVN . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of a GAL reporter gene along with expression plasmids encoding c Jun plus c Fos , or the catalytic subunit of PKA ( PKAbeta ) , resulted in a 4 to 8 fold enhancement of GAL reporter gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased AP 1 DNA binding activity in RAW264 . 7 cells was associated with raised levels of c Fos expression and induction of mRNA for the AP 1 responsive tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mitogen activated protein kinase activity was evaluated using an in gel assay system , and the mRNA levels of c fos and c jun were determined by quantitation of competitive reverse transcription polymerase chain reaction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The association between c fos and c jun expression and estrogen and progesterone receptors is lost in human endometrial cancer . ^^^ In normal human endometrium , expressions of the proto oncogenes c fos and c jun parallel . ^^^ In this study , we analyzed endometrial cancer tissues for c fos and c jun messenger RNA ( mRNA ) expression by Northern blotting . ^^^ Messenger RNA for c fos was detected in 35 of 37 cancer tissues and mRNA for c jun in 37 of 40 tissue samples studied . ^^^ No correlation was observed between the relative mRNA levels of c fos and c jun , suggesting distinct control mechanisms , if any , in endometrial cancer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 DNA binding capacity of c fos , and to a smaller extent c jun , was increased by glucocorticoids later than after serum treatment . ^^^ Furthermore , ras inhibited the glucocorticoid dependent induction of c fos protein and mRNA , leading to changes in AP 1 composition as compared to normal cells . ^^^ As assessed by transient transfection luciferase assays , glucocorticoids induced significantly a minimal promoter containing 3 copies of an AP 1 DNA binding site as well as the murine c fos 276 to +112 promoter in non transformed cells . ^^^ Dexamethasone treatment induced transiently c jun mRNAs , in contrast to the sustained expression of c fos , whereas its effect on junB expression resulted in a later increase . ^^^ Dexamethasone dependent stimulation of c fos and c jun was modulated predominantly at the level of transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of transcription factors such as NF kappaB and activator protein 1 ( AP 1 ) may be linked to increases in early response genes ( e . g . , c jun and c fos ) which govern proliferation , apoptosis , and inflammatory changes in the cells of the lung . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , we found that NBPhox can also enhance second messenger mediated activation of the c fos promoter and several enhancers , including cyclic AMP response element , the binding site for activator protein 1 , and serum response element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Retinoic acid repressed the expression of c fos and c jun and induced apoptosis in regenerating rat liver after partial hepatectomy . ^^^ Northern blot analysis revealed that RA repressed the expression of c fos and c jun at 15 and 30 min with the up regulation of retinoic acid receptor gamma ( RARgamma ) and RARbeta at 2 h after PH . ^^^ These results suggest that RA exerts the antiproliferative activity only on the early stage of liver regeneration accompanied by the repression of c fos and c jun expression and induction of apoptosis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The activation of MAPK by these compounds may lead to the induction of cell survival / protection genes such as c jun , c fos , or Phase 2 drug metabolizing enzymes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of Ang 2 induced AP 1 activation with c fos antisense oligodeoxynucleotide led to a significant reduction of TGF beta ( 1 ) mRNA in VSMCs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra 1 , Fra 2 , and c Fos bound to AP 1 but that prior treatment of the cells with TGFbeta reduced dramatically c Fos binding , suggesting that c Fos might be playing a negative regulatory role in clusterin gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although c Fos expression did not alter mSP B transcription , Jun D enhanced mSP B promoter activity and reversed inhibition of mSP B by c Jun or Jun B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of the c fos , c jun , and egr 1 genes is essentially absent in cells expressing gp 130 with a Y759F mutation , which is unable to recruit SHP 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The genes examined include c fos , c jun , vascular endothelial growth factor , and creatine kinase B , which are all known to be primary responses to estrogen administration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We measured c fos , c jun , c myc , and hsp 70 induction in preconditioned ( 2 10 5 min ischemia / 10 min reperfusion ) and control rabbit hearts that either underwent 30 or 120 min coronary occlusion and 60 min reperfusion , or did not undergo subsequent sustained ischemia ; the latter hearts were allowed to recover for 0 , 1 , 3 , 6 , 24 , 48 , 72 , or 96 hours . ^^^ Both c fos and c jun in ischemic tissue were strongly induced by ischemia reperfusion injury and preconditioning pretreatment . ^^^ Induction of c fos and c jun preceded that of Hsp 70 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Injections of DA produce a strong and prolonged activated protein 1 ( AP 1 ) activity that contains c fos , c jun , and phosphorylated c jun protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In rat cardiocytes , AngII also causes induction of many immediately early genes ( c fos , c jun , jun B , Egr 1 and c myc ) and induces also late markers of cardiac hypertrophy ( skeletal alpha actin and atrial natriuretic peptide expression ) and growth factors ( TGF beta 1 gene expression ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cellular senescence is characterized by flattened enlarged morphology , inhibition of DNA replication in response to growth factors , inability to phosphorylate the pRb tumor suppressor protein , inability to produce c fos or AP 1 and overexpression of a variety of genes , notably p 21 ( CIP 1 / WAF 1 ) and p 16 ( INK ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoblotting and supershift assays revealed much higher expression of both immunoreactive c Jun and c Fos in hippocampal cytosolic fractions in response to the administration of kainate than N methyl D aspartate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Limited proteolysis by V 8 protease and supershift , as well as immunoblotting assays using antibodies against c Fos and c Jun , invariably gave support for differential expression by N methyl D aspartate and kainate of the activator protein 1 complex consisting of different partner proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the molecular basis of osteogenesis in DC , we examined the temporal pattern of gene expression of the proliferation marker histone H 4 , immediate early response genes ( IEGs ) , c fos , c jun , c myc , osteoblast phenotype associated genes , osteocalcin ( OC ) , osteopontin ( OP ) , type 1 collagen ( COL1A1 ) , alkaline phosphatase ( ALP ) , parathyroid hormone receptor ( PTHR ) and matrix modifying enzyme , matrix metalloproteinase 9 ( MMP 9 ) . ^^^ In vitro , ROS 17 / 2 . 8 cells expressed detectable levels of c fos , c jun , c myc , OC , OP , ALP , COL1A1 , and PTHR but not MMP 9 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PDGF BB provoked induction of c fos mRNA and increases in binding activity to the AP 1 site . ^^^ The c fos induction , the increased AP 1 binding activity and the acceleration of DNA synthesis were all attenuated by genistein ( 100 microM ) or MAPK kinase inhibitor ( 10 or 50 microM PD 98059 ) . ^^^ Interestingly , protein kinase C inhibitor ( 250 nM calphostin C ) attenuated the increases of AP 1 binding activity to some extent , but did not inhibit the c fos induction at all . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : The normal corneal epithelium showed no staining with antibodies against c Fos , Fra 2 , FosB , c Jun or JunB , whereas the limbal and bulbar conjunctival epithelia were positive for c Fos , Fra 2 , and c Jun . ^^^ The dsyplastic epithelium showed positive labelling for c Fos , Fra 2 , c Jun , and JunD throughout its thickness . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neuron loss is not associated with increased vulnerability to nuclear DNA fragmentation , and nor is it accompanied by modifications in the expression of the proteins Bcl 2 and Bax , and transcription factors c Fos and c Jun , thus suggesting that these proteins are probably not involved in cell death in these disorders . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our findings suggested that osteocalcin , a bone formation marker , c fos and c jun genes , and family protein products ( AP 1 ) interacted to restore the normal cell function which deteriorated in the low calcium environment . . ^^^ However , the low calcium environment enhanced the mRNA expressions of c fos , c jun and osteocalcin , a specific marker of the osteoblast phenotype . ^^^ We further studied the differential expressions of c fos and c jun in relation to their responses to serum as a function of phenotypic development in the low calcium environment . ^^^ Both c fos and c jun expressions were highly activated by treatment with epidermal growth factor ( EGF ) , but the magnitude of activation was significantly larger under the low calcium condition than the normal condition at each stage . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we report that the EGF receptor kinase inhibitor AG 1478 and the ERK kinase inhibitor PD 98059 markedly inhibited angiotensin 2 induced c Fos expression and protein synthesis but not c Jun expression in these cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JNKs activity is chronically enhanced in cardiac hypertrophy of hypertensive rats or angiotensin 2 infused rats , which is followed by the increase in activator protein 1 ( AP 1 ) activity composed of c Fos and c Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Co transfection with c Fos and c Jun expression vectors in cells synergistically increased the promoter activity of 12 lipoxygenase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Enhanced DNA binding activity of AP 1 and Elk 1 correlated with increased gene expression of c fos , but not c jun , at 2 h . c myc gene expression was also induced by As ( 3 ) and As ( 5 ) , albeit at a later time point ( 6 h ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous work by others and in our laboratory , using an in vitro uniform laminar shear stress model , has identified various shear stress response elements ( SSREs ) within the promoters of certain endothelial genes that regulate their expression by interacting with various transcription factors , including nuclear factor kappaB ( NF kappaB ) , early growth response 1 ( Egr 1 ) , and activator protein 1 ( AP 1 , composed of c Jun / c Jun and c Jun / c Fos protein dimers ) . ^^^ In the current study , we have examined the topographical patterns of NF kappaB , Egr 1 , c Jun , and c Fos activation in a specially designed in vitro disturbed laminar shear stress model , which incorporates regions of significant spatial shear stress gradients similar to those found in atherosclerosis prone arterial geometries in vivo ( eg , arterial bifurcations , curvatures , ostial openings ) . ^^^ Using newly developed quantitative image analysis techniques , we demonstrate that endothelial cells subjected to disturbed laminar shear stress exhibit increased levels of nuclear localized NF kappaB , Egr 1 , c Jun , and c Fos , compared with cells exposed to uniform laminar shear stress or maintained under static conditions . ^^^ In addition , individual cells display a heterogeneity in responsiveness to disturbed flow , as measured by the amount of NF kappaB , Egr 1 , c Jun , and c Fos in their nuclei . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the extent to which phosphatidylinositol 3 kinase ( PI 3 kinase ) and Rac , a member of the Rho family of small GTPases , are involved in the signaling cascade triggered by tumor necrosis factor ( TNF ) alpha leading to activation of c fos serum response element ( SRE ) and c Jun amino terminal kinase ( JNK ) in Rat 2 fibroblasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of mammalian cells to ultraviolet ( UV ) light and other DNA damaging agents triggers the UV response which is characterized by induction of a large number of genes including c fos , c jun , and the genes for DNA repair enzymes and cell cycle regulatory proteins such as p 21 WAF1 and p 53 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Apoptosis , lipid peroxidation and DNA damage were significantly higher after exposure to P ( GFLG ) ADR , as reflected by simultaneous activation of p 53 , c fos in A 2780 cells ) or c jun ( A2780 / AD ) signaling pathways and inhibition of the bcl 2 gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
GATA 4 , Nkx 2 . 5 , Egr 1 , c jun and c fos expression were increased after 3 , 7 and 14 days of treatment . ^^^ After PE or ISO drug withdrawal the HW / BW was normal and Egr 1 , c jun , c fos and GATA 4 , but not Nkx2 . 5 , expression dropped to control levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
No differences are demonstrated in overall estradiol binding in vascular smooth muscle cells obtained from male or female animals : however , differences in c jun , c fos and TIEG gene expression were gender related . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : ( 1 ) LPS treatment compared with vehicle increases c fos mRNA accumulation 5 fold and AP 1 DNA protein binding ( electrophoretic mobility shift assay ) , which precedes either IL 12 p 35 or IL 12 p 40 mRNA accumulation . ( 2 ) LPS induces a significant increase in IL 12 p 70 protein , IL 12 p 40 mRNA , and the transcription rate in the Homo KO group compared with either the Hetero KO or WT groups . ( 3 ) Compared with vehicle control , we demonstrate that interferon gamma priming increases LPS stimulated macrophage IL 12 p 70 protein in the Hetero KO or WT groups to the level of the Homo KO group but has no significant effect on the Homo KO group . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antisense oligonucleotides to c fos and c jun inhibit intimal thickening in a rat vein graft model . ^^^ BACKGROUND : C fos and c jun are 2 immediate early genes that have been implicated in the stimulation of vascular smooth muscle cell proliferation and migration . ^^^ In previous experiments in our laboratory with a rat vein graft model a 2 to 3 fold increase of messenger RNA of c fos and c jun were noted 1 hour after vein graft perfusion . ^^^ Because c fos and c jun are up regulated after the perfusion of vein grafts , the purpose of this study was to delineate the temporal expression of c fos and c jun protein and to study the effect of antisense oligonucleotides ( ASO ) to c fos and c jun on intimal thickening observed in this model . ^^^ Additional rats underwent bypasses and at the time of the procedure 1 graft was treated with a pluronic gel containing an ASO to c fos , c jun , or sense and the contralateral side was treated with pluronic gel only . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Under oxidative stress , c Fos and c Jun contributed to the AP 1 binding in the embryo ; in the yolk sac , a c Fos shifted complex emerged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The N20 . 1 murine OL cell line provides a model of an intermediate stage of OL maturation in which to study responses to Ca ( 1 ) increases with regard to viability , as well as the expression of mRNAs for myelin basic protein ( MBP ) , proteolipid protein ( PLP ) , DM 20 , SCIP , and the immediate early genes ZIF 268 , c fos , and c jun . ^^^ With both agents , ZIF 268 , c fos , and c jun mRNA levels were unaffected after 1 hr ; c jun mRNA levels showed a significant increase after 3 hr of thapsigargin treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 complex at both sites contained a Fos related protein with c Jun in SH EP cells and c Fos with a Jun related protein in SK N SH cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , prooxidant conditions led to a strong induction of c jun and c fos mRNA levels resulting in a 4 fold higher transactivation of the transcription factor AP 1 in the Mn SOD overexpressing cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershifts , with antibodies against c Fos and phospho c Jun constituencies of the AP 1 dimer , revealed an increased amount of phosphorylated c Jun in the late postischemic phase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive urokinase receptor expression in HCT 116 cells required an intact AP 1 motif in the promoter ( at 184 ) and electrophoretic mobility shifting assays indicated less c Jun , JunD , c Fos and Fra 1 bound to this motif in the K Ras disrupted cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transactivation studies with c Jun and c Fos expression plasmids indicated that PPARs negatively interfere with the activator protein 1 signaling pathway , which mediates thrombin activation of ET 1 gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Intracellular signaling of gp 34 , the OX 40 ligand : induction of c jun and c fos mRNA expression through gp 34 upon binding of its receptor , OX 40 . ^^^ We demonstrated that OX 40 binding resulted in increase in c jun and c fos mRNA levels in this transfectant by Northern blot analysis , which was blocked by the pretreatment with anti gp 34 Ab . ^^^ The studies with various gp 34 deletion mutants showed that the cytoplasmic portion including the amino acid sequence 16 21 ( RPRFER ) was required for the induction of c jun and c fos mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
D dimer increased the binding activity of the transcription factor activator protein 1 components c fos / junD and c fos mRNA levels in a time and concentration dependent manner to a greater extent than fibrinogen . ^^^ Mutations within the AP 1 like element ( 59 to 52 bp ) in the PAI 1 gene affected D dimer induced transcriptional activity , c fos / junD DNA binding , and basal and c fos inducible PAI 1 transcriptional activity . ^^^ D dimer induced binding of c fos / junD to the highly conserved and unique AP 1 like element in the PAI 1 gene provides a mechanism whereby specific fibrin fragments control fibrin persistence at sites of inflammation , fibrosis , and neoplasia . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As distal targets and mediators of signal transduction pathways , activator protein 1 ( AP 1 ) , c Jun , and c Fos are among the primary regulators of genes involved in cell function , proliferation , and differentiation . ^^^ Adenovirus mediated overexpression of c Jun and c Fos induces intercellular adhesion molecule 1 and monocyte chemoattractant protein 1 in human endothelial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : Significantly greater expression of c FOS , phosphorylated c JUN , and phosphorylated JUN N terminal kinase ( JNK ) protein has been identified in CR than in CS subjects . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We propose that the differential induction of c jun / c fos ( AP 1 ) gene expressions and sequential activation of PARP activity are essential in anoxia / hyperoxia induced apoptosis . . ^^^ These results were in accordance with the expressions of c jun and c fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further experiments demonstrated that the expression of immediate early genes , including c jun , c fos and egr 1 , was also induced by copper treatment in these cells , although only egr 1 mRNA was induced in a time and dose dependent manner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NF kappaB and AP 1 components c Fos and c Jun were shown to physically associate by yeast two hybrid assays and electrophoretic mobility shift assays . ^^^ Coexpression of NF kappaB and c Fos or c Jun synergistically transactivated the HIV 1 LTR through the NF kappaB sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : With specific molecular probes , in situ hybridization was used to detect the expression of c myc transgene , IGF 2 gene as well as c jun , c fos , and c H ras oncogenes in the liver sections from WHV / myc transgenic mice in different stages of the carcinogenic process . ^^^ The c jun , c fos and c H ras genes expressed more intensely in the livers from preneoplastic WHV / myc mice than from normal mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of reduced SF / HGF and c met expression on 1 ) SF / HGF dependent induction of immediate early genes ( c fos and c jun ) , indicative of signal transduction ; 2 ) anchorage independent colony formation ( clonogenicity ) , an in vitro correlate of solid tumor malignancy ; and 3 ) intracranial tumor formation in immunodeficient mice were quantified . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ifi 202 encodes the p 202 protein whose overexpression is growth inhibitory and which can bind and inhibit the activity of numerous transcription factors including c Jun , c Fos , NF kappaB , E2F 1 , E2F 4 , MyoD , and myogenin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Such a notion is supported by the findings that timp 1 mRNA accumulation occurs in the rat hippocampus after either kainate or pentylenetetrazole evoked seizures with a delayed , in comparison with AP 1 components , time course , as well as with spatial overlap with c Fos protein ( major inducible AP 1 component ) expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The C terminal 158 residues of Bcl 3 exhibited an autonomous transactivation function and interacted with specific subregions of the AP 1 components c Jun and c Fos , CREB binding protein / p300 , and steroid receptor coactivator 1 , as demonstrated by the yeast and mammalian two hybrid tests as well as glutathione S transferase pull down assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we have investigated for each factor and regulatory cascade of the intermediate step of immediate early gene induction , that is , c myc , c jun , jun D , jun B , c fos , fos B , fra 1 , fra 2 , and egr 1 ; fra 1 and fra 2 expressions were very low . ^^^ TSH or forskolin increased the levels of c myc , jun B , jun D , c fos , and fos B while decreasing those of c jun and egr 1 . ^^^ This suggests that the effect of insulin on mitogenesis might result from quantitative differences in the transcription complexes formed . ( 3 ) c myc , c fos , and jun B mRNA induction by all stimulating agents , whether inducing cell hypertrophy , or growth and dedifferentiation , or growth and differentiation , suggests that , although these expressions are not sufficient , they may be necessary for the various growth responses of thyroid cells . ( 4 ) The inhibition of c jun and egr 1 mRNA expression , and the marked induction of jun D mRNA appear to be specific features of the TSH cAMP pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^ For c jun , junB , c fos and fra 2 , a relatively uniform expression pattern without significant differences among tumors was observed . junD protein amounts varied strongly in the tumor specimens . fosB expression levels also varied strongly in the tumors , weak / absent expression being found in 47 % , while 45 % exhibited strong / very strong levels of expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While the expression of c myc , interferon regulatory factor 1 or 2 ( IRF 1 or IRF 2 ) was not effective , CAT activity was strongly enhanced in both JEG 3 and HeLa cells with the co transfection of c Jun or c Jun plus c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , the monoterpene perillyl alcohol ( POH ) was found to induce transient expression of the c jun and c fos genes transcriptionally . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has been shown previously that the immediate early genes , c fos and c jun mRNA are induced in the 1 day old chick forebrain after one trial passive avoidance training in which chicks learn to avoid pecking at a bitter tasting bead . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Blockade of calcium influx through nifedipine sensitive voltage gated calcium channels reduced buserelin induced activation of extracellular signal regulated kinase ( ERK ) and c Fos while activation of c Jun N terminal kinase and c Jun was unaffected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos , fos B , c jun , jun B , NGFI A , and NGFI B mRNA was rapidly upregulated in the endothelial , myocardial , and smooth muscle cells of coronary vessels by 15 45 min after the onset of immobilization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined the mechanisms of interaction of crocidolite asbestos fibers with the epidermal growth factor ( EGF ) receptor ( EGFR ) and the role of the EGFR extracellular signal regulated kinase ( ERK ) signaling pathway in early response protooncogene ( c fos / c jun ) expression and apoptosis induced by asbestos in rat pleural mesothelial ( RPM ) cells . ^^^ The tyrphostin AG 1478 , which inhibits the tyrosine kinase activity of the EGFR , but not the tyrphostin A 10 , which does not affect EGFR activity , significantly ameliorated asbestos induced increases in mRNA levels of c fos but not of c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of several genes ( including heme oxygenase 1 , HO 1 ; collagenase ; the CL 100 phosphatase and the nuclear oncogenes , c fos and c jun ) is induced following physiological doses of UVA to cells and this effect can be strongly enhanced by removing intracellular glutathione or enhancing singlet oxygen lifetime . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nGRE conferred transcriptional activation by both cAMP and overexpressed c jun or c fos AP 1 nucleoproteins as well as specific glucocorticoid dependent repression to a heterologous promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibodies raised against peptides corresponding to conserved domains of mammalian c Jun and c Fos detected bands of 40 and 60 kDa , respectively , in a nuclear epimastigote preparation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although MCF 7 cells respond to estrogen by inducing the AP 1 family components c Fos and c Jun , HaCaT cells expressing estrogen receptor do not . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although GLP 2 stimulated the expression of c fos , c jun , junB , and zif 268 , and transiently increased p 70 S6 kinase in quiescent BHK GLP 2R cells , GLP 2 also inhibited extracellular signal regulated kinase 1 / 2 and reduced serum stimulated Elk 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In Rat 1 fibroblasts , we measured the effect of IL 6 on matrix metalloproteinase 13 ( MMP 13 ) , c jun , junB , and c fos gene expression , binding of activator protein 1 ( AP 1 ) to DNA , amount of AP 1 proteins , immunoreactive MMP 13 and TIMP 1 proteins , and Jun N terminal kinase activity . ^^^ This effect seems to be mediated by the induction of c jun , junB , and c fos gene expression , by the binding of AP 1 to DNA , by increasing phosphorylated c Jun , and by the inhibition of serine / threonine phosphatase activity . ^^^ This effect was accompanied by a marked increase in c Jun , JunB , and c Fos mRNA , as well as in c Jun protein and its phosphorylated form . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of phospholipase C gamma 1 suppresses UVC induced apoptosis through inhibition of c fos accumulation and c Jun N terminal kinase activation in PC 12 cells . ^^^ Northern blot analysis revealed that UVC induced c fos mRNA accumulation was inhibited in PLC gamma 1 overexpressing cells , while c jun expression was not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we show that CHOP interacts with members of the immediate early response , growth promoting AP 1 transcription factor family , JunD , c Jun , and c Fos , to activate promoter elements in the somatostatin , JunD , and collagenase genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results may explain how p 53 down regulates the expression of some estrogen responsive genes such as c fos , c jun , TPA , and bcl 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mammalian proto oncogenes c jun and c fos are situated at the end of multiple signal transduction pathways and activation of their products Jun and Fos , components of the transcription factor AP 1 , are able to regulate gene transcription in response to extracellular stimuli . ^^^ Djun and Dfos , the products of the Drosophila proto oncongenes Djun and Dfos , are similar in size and sequence to their mammalian counterparts c Jun and c Fos and are related to their mammalian counterparts by their antigenic properties . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The tumor promoter 12 O tetradecanoylphorbol 13 acetate ( TPA ) can induce expression of many immediate early genes , such as c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To further characterize the cellular and molecular mediators of the anabolic response to PTH , we examined the effect of intermittent synthetic hPTH 1 34 on the expression and localization of selected early response genes , c fos , c jun , c myc , and IL 6 protein , in bone tissue by immunohistochemistry . ^^^ Early response genes , c fos , c jun and IL 6 , were strongly expressed in osteoblasts , osteocytes , and megakaryocytes in bones 1 hour after PTH , when compared with vehicle treated controls or sections from rats , 24 hours after PTH injection . ^^^ Scattered islands of hematopoietic cells in the bone marrow stained more strongly for c fos than either c jun or c myc , but neither localization nor stain intensity were regulated by PTH at the time points examined . ^^^ We conclude that during the immediate early phase of the anabolic response , PTH regulates c fos , c jun , and IL 6 expression in osteoblasts , osteocytes , megakaryocytes , and selected bone marrow hematopoietic cells in bone . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription factors of the AP 1 / ATF family , including c Fos , c Jun , and ATF 2 , play an important role in the regulation of cell proliferation and differentiation , and changes in their levels and / or activities may contribute to oncogenesis . ^^^ The expression of c fos and c jun genes was affected differently by the oncogenic transformation . ^^^ By using antibodies to c Jun and c Fos proteins in electrophoretic mobility shift assays ( EMSA ) , we showed that E1A + cHa ras transformants did not contain c Fos under any condition of cell cultivation and growth factor stimulation , whereas c Jun was constitutively upregulated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Isolated DH PH 2 module activates c Jun NH ( 2 ) terminal kinase and the c fos promoter in response to LPA , providing the basis for an ERK independent mechanism . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The UVB mediated enhanced expression of the early response genes , c fos and c jun in human epidermal keratinocytes was reduced in a dose dependent manner by SBTE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study was designated to test the hypothesis that blockade of brain AT ( 1 ) receptors improves the recovery from focal cerebral ischemia and reduces expression of AP 1 transcription factors c Fos and c Jun , which have been associated with programmed cell death and neurodegeneration . ^^^ Twenty four hours after ischemia , neurological outcome was evaluated and expression of c Fos and c Jun proteins in the brain was studied immunocytochemically . ^^^ RESULTS : Focal brain ischemia resulted in a strong induction of c Fos and c Jun proteins in the cortex , which positively correlated with the degree of neurological deficits . ^^^ Treatment of rats with irbesartan significantly improved neurological outcome of focal cerebral ischemia when compared with the vehicle treated group and markedly reduced the expression of c Fos and c Jun proteins in the cortex on the ligated side of the brain . ^^^ CONCLUSIONS : The present study shows a relationship between c Fos and c Jun expression and neurological outcome after focal brain ischemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although no signaling defect could be detected , we did find that naive / resting Jak 3 negative T cells have substantially reduced levels of the transcription factor NF AT 1 and moderately reduced levels of c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The influence of nicotine on the expression of Fos family proteins , which specifically formed complexes with the AP 1 sequence , was assessed . mRNA for c Fos , c jun and jun B were up regulated at 0 . 5 h after nicotine treatment , elevated c Fos also being apparent after withdrawal . ^^^ These results indicate that nicotine treatment may affect the transcriptional activity of many genes through c Fos and c Jun protein expression in neural cells , and that Fra 1 protein may make a contribution . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While NGF somewhat increased c Fos and c Jun protein levels transiently , it had a more robust and persistent stimulatory effect on Jun B protein levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Glial changes following traumatic injury to glial monolayers as well as to neuronal glial co culture systems in vitro were examined with a focus on the expression of mRNAs coding for the immediate early genes ( IEG ) c fos , c jun and zif / 268 , demonstrated using in situ hybridization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To elucidate the endocrine mechanism of human parturition , the expression of c Jun and c Fos mRNA were examined in relation to estrogen receptor ( ER ) and progesterone receptor ( PR ) in human myometrium . c Jun mRNA was detected in all myometrial tissues ( n=5 ) during labor but not before labor ( n=5 ) and in oxytocin resistant postterm pregnancy ( n=3 ) . c Fos mRNA was detected in only one myometrial tissue from a woman in labor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Insulin treatment did not alter levels of messenger RNAs ( mRNAs ) for c fos , c jun , and c myc . ^^^ EGF induced an increase in c myc , but not c fos or c jun , mRNA levels in subconfluent hepatocyte cultures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , gp 120 protein at lower concentrations enhanced mRNA expression of c fos and at higher concentrations promoted mRNA expression of c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , we investigated the effect of extracellular AD levels on c Fos protein and activator protein 1 ( AP 1 ) binding in the basal forebrain of rats . ^^^ Adenosine and behavioral state control : adenosine increases c Fos protein and AP 1 binding in basal forebrain of rats . ^^^ At the end of the perfusion period the basal forebrain tissue was analyzed for the levels of c Fos protein and AP 1 binding . ^^^ The levels of c Fos protein and the AP 1 DNA binding were high in the basal forebrain of both sleep deprived animals and in animals perfused with AD . ^^^ The results suggest that AD might mediate , at least in part , the long term effects of sleep deprivation by inducing c Fos protein and subsequent AP 1 binding . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts indicated that the AP 1 complex consists of c Jun , c Fos , JunD , and possibly JunB proteins , and that the NF kappaB complex contains p 50 , p 65 , and c Rel proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Indeed , several genes induced by Abeta in wild type neurons were also induced in c jun deficient neurons , including c fos , fosB , ngfi B , and ikappaB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein composition of the AP 1 transcription factor complex activated by carbachol stimulation of muscarinic receptors was analysed in control and chronic ethanol exposed cells using a supershift assay with specific antibodies against c Fos , Fos B , c Jun , Jun B and Jun D proteins . ^^^ Supershift analysis revealed that the carbachol induced AP 1 complex was composed predominantly of Jun D and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have studied the contribution of c Fos / activator protein 1 ( AP 1 ) to antigen specific T cell response with reference to T cell anergy by increasing c Fos / AP 1 in vivo and in vitro . ^^^ Electrophoretic mobility shift assay with nuclear protein from the transformants showed that overexpression of the c fos gene compensated the amounts of AP 1 in the nuclei of Con A treated T ( h ) 1 clones . ^^^ Thus , increased c Fos / AP 1 confers resistance against anergy induction on antigen specific T cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The heart of transgenic mice showed elevation of sialylated O glycan and increases of c fos gene expression and AP 1 activity , which are characteristics of cardiac stress . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In U 373MG glioblastoma cells , which also express BRS 1 , and U 87MG cells , cultured in vitro , GRP ( 14 27 ) induced the expression of c fos mRNA , and some c jun mRNA , in a time dependent manner with the maximal effect occurring 2 h after the stimulation and a return to basal levels after 8 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The sensitivity of c Jun and c Fos proteins to calpains depends on conformational determinants of the monomers and not on formation of dimers . ^^^ Motifs responsible for recognition by calpains have not been characterized yet , and recently a role for PEST motifs in this process has been ruled out . c Fos and c Jun transcription factors are highly sensitive to calpains in vitro . ^^^ Using in vitro degradation assays and site directed mutagenesis , we report here that susceptibility to calpains is primarily determined by conformational determinants of the monomers and not by the quaternary structure of c Fos and c Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNA mobility shift assays showed that the in vitro translated Jem protein interacts neither with the DNA binding site of AP 1 , nor directly with in vitro co translated c Fos or / and c Jun proteins bound to this specific sequence . ^^^ Interestingly , Jem 1 1 increased substantially the transcriptional activity of c Jun ( three fold ) and more strongly that of ectopically co expressed c Fos and c Jun ( five to six fold ) , as measured by a CAT reporter gene driven by a heterologous promoter containing the AP 1 binding site of the human collagenase gene . ^^^ We conclude that the 45 kDa nuclear product of the JEM 1 gene has features of a novel transcription cofactor , which is enhancing AP 1 activity without directly interacting with c Jun or c Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since c fos expression may play an important role in UVB induced AP 1 activation , and AP 1 activation is known to play a role in tumor promotion , both p 38 and ERK could be potential targets for chemoprevention of skin cancer . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Tissue differences but limited sex steroid responsiveness of c fos and c jun in human fibroids and myometrium . ^^^ Sex steroids influence the growth of mammalian uterine tissues and the proto oncogenes c fos and c jun have been implicated in the cascade of cellular events induced by the cyclic influence of oestrogen and progesterone . ^^^ The mRNA expression of c fos and c jun in fibroids was significantly lower than in homologous myometrium . ^^^ These results demonstrate a tissue difference in the expression of c fos and c jun between myometrium and fibroids . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Free ADR and HPMA copolymer ADR conjugates had different impacts on the expression of MDR 1 , MRP , c fos , c jun , and bcl 2 genes which encode the P glycoprotein ( MDR 1 ) and the multidrug resistance associated protein ( MRP ) efflux pumps , and play an important role in cell death signaling pathways ( c fos , c jun , and bcl 2 ) . ^^^ There were differences in the expression of c fos , c jun , and bcl 2 genes after the incubation of OVCAR 3 cells with free and HPMA copolymer bound ADR indicating differences in activation of cell death signaling pathways . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Edg 3 and Edg 5 transduced S1P evoked signaling events relevant to cell proliferation and survival , including activation of the ERK / MAP kinases , and immediate early induction of c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel shift analysis in the presence of specific antibodies to c Jun , JunB , JunD , c Fos , and CREB / ATF showed that the AP 1 complexes were probably c Jun / c Jun , c Fos / c Jun , c Fos / JunB , or c Jun / JunB dimers . ^^^ Northern blot analysis confirmed that c jun , junB , and c Fos were the principal proto oncogenes induced by CalC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dimerization of c Fos with other bZIP proteins of the Jun family is necessary to enable transcriptional efficacy at the AP 1 sequence of putative target gene promoter regions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JNK and c Jun but not ERK and c Fos are associated with sustained neointima formation after balloon injury . ^^^ BACKGROUND : Formation of neointima after balloon angioplasty is regulated via inducible transcription factors ( ITF ) , such as c Jun and c Fos , depending on mitogen activated protein ( MAP ) kinases , which have been shown to be activated after balloon injury . ^^^ Cryocut sections were stained using antibodies directed against c Jun , phosphorylated c Jun , c Fos , c Jun amino terminal kinase ( JNK ) , extracellular signal related kinase ( ERK ) , von Willebrand factor , ki 67 antigen , and alpha actin . ^^^ In contrast , c Fos expression was restricted to 30 min and , less pronounced than c Jun and JNK , was visible after 7 days . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased activity of the transcription factor activator protein 1 ( AP 1 ) in retinas of light exposed c fos ( + / + ) mice indicated an acute contribution of AP 1 to apoptosis induction . ^^^ Activated AP 1 mainly consisted of c Fos / Jun heterodimers . ^^^ In c fos ( / ) mice , AP 1 activity remained unchanged , indicating that no other Jun or Fos family member could substitute for c Fos . ^^^ Like damaging light , N methyl N nitrosourea ( MNU ) induced AP 1 containing c Fos in c fos ( + / + ) mice and did not induce AP 1 in c fos ( / ) mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Topical application of 5 nmol TPA to CD 1 mice once daily for 5 days caused epidermal hyperplasia , and increases in the levels of c Fos , c Jun and c Myc in the suprabasal layer of epidermis and the muscle layer of dermis . ^^^ Immunocytolochemical examination showed that pretreatment of 1 mumol crocetin repressed the TPA induced epidermal hyperplasia and the expressions of c Jun , c Fos and c Myc to the extent of 47 , 44 and 45 % respectively . ^^^ These data indicate that crocetin suppresses the TPA induced skin carcinogenesis maybe via its antioxidant property which , in turn , leads to a reduction in the TPA induced expressions of c Jun , c Fos and c Myc in mouse epidermis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In situ hybridization was used to detect the induction of immediate early gene ( IEG ) c fos and c jun mRNA ' s and the levels of AChE mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , induction of c fos resulted in the concomitant increase in the expression of fra 1 and c jun , further highlighting the importance of AP 1 transcription factors in chondrocyte differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assay showed that PDTC inhibited NF kappaB binding activity in heart and kidney , whereas AP 1 activity in the kidney was not decreased . dTGR exhibited increased left ventricular c fos and c jun mRNA expression . ^^^ PDTC treatment reduced c fos but not c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of Bcl 2 , p 53 , c jun and c fos protooncogenes in keloids and hypertrophic scars . ^^^ The c jun and c fos protooncogenes are transactivating factors also involved in fibroblast proliferation . ^^^ The c jun and c fos , at protein and mRNA level , and Ki 67 nuclear antigen expression were also investigated . ^^^ The c jun and c fos mRNA and protein expression was mainly found in dermal fibroblast like cells and elongated perivascular cells in all skin biopsies , and similar immunostaining pattern was observed for Ki 67 antigen . ^^^ Our results suggest that Bcl 2 , c jun and c fos protein expression and lack of p 53 detection in fibroblast like and perivascular spindle cells are related to increased fibroblast proliferation , confirmed by Ki 67 positivity , probably due to alteration of these regulatory apoptotic genes resulting in pathological scarring . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^ The osteoclast differentiation factor Rankl ( also known as TRANCE , ODF and OPGL ; refs 8 11 ) induces transcription of Fosl 1 in a c Fos dependent manner , thereby establishing a link between Rank signalling and the expression of Ap 1 proteins in osteoclast differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These are : 1 ) five E box motifs which are bound by members of the basic helix loop helix family of transcription factors ; 2 ) two dGC rich elements which bind multiple complexes including Sp 1 ; 3 ) a single AP 1 element which binds a complex containing c Fos or Fos related antigens . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction and potentiation of c Jun and c Fos expression in spinal neurons mediated by NK 1 and NK 2 receptors . ^^^ Specific antagonists were used to determine NK 1 and NK 2 receptor mediation of the expression of c Jun and c Fos inducible transcription factors . ( ITFs ) in dorsal horn neurons . ^^^ The induction of c Jun by C fiber stimulation was strongly reduced in the superficial laminae by NK 1 and NK 2 antagonists , but only weakly in the deep laminae by NK 2 antagonism . c Fos induction was reduced in all laminae by both NK 1 and NK 2 antagonism but less than with c Jun . ^^^ The potentiation of c Jun expression , caused by a preceding stimulus , was abolished in all laminae by NK 1 and NK 2 antagonists , whereas that of c Fos was reduced in all laminae but again less than that of c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PACAP potently stimulated the expression of c fos , fosB junB and junD , but not c jun mRNAs , at doses of 0 . 1 10 nM , as revealed by Northern blot analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We immunohistochemically located c Fos and c Jun , the major components of transcription factor activator protein 1 ( AP 1 ) , in normal epithelia of rat cornea and conjunctiva to determine the expression of these genes in the ocular surface epithelia . ^^^ Immunolocalization of c Fos and c Jun in rat ocular surface epithelium . ^^^ Immunoreactivity for c Fos was detected in the nuclei of basal cells of the limbal and conjunctival epithelia , while that for c Jun was detected in the cytoplasm of the cells of these epithelia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , cotransfection of the architectural transcription factor high mobility group ( HMG ) 1 ( Y ) protein with c Fos and c Jun markedly increased trans activation of the CD 44 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using specific antibodies against AP 1 complex proteins , it was demonstrated by gel supershift assay that VT preferentially affected phosphorylated c Jun , Jun B , c Fos , and Fra 2 binding activities , whereas it did not alter Jun D and Fra 1 binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ODC inhibition not only leads to polyamine depletion but also leads to inhibition of cell proliferation and regulates the expression of the immediate early genes c fos , c myc , and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We evaluated lung AP 1 binding as well as that of the AP 1 subunit proteins c Fos , c Jun , phosphorylated c Jun , Jun B , and Jun D after exposure to > 95 % O ( 2 ) for 3 days . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Prostaglandin E ( 2 ) ( PGE ( 2 ) ) induces the c fos and c jun expressions via the EP ( 1 ) subtype of PGE receptor in mouse osteoblastic MC3T3 E 1 cells . ^^^ This study examined which subtype ( s ) of PGE receptors is involved in the induction of c fos and c jun by PGE ( 2 ) in MC3T3 E 1 cells . ^^^ PGE ( 2 ) dose dependently induced c fos and c jun mRNA expressions in MC3T3 E 1 cells . ^^^ Of the PGE analogs , 17 phenyl omega trinor PGE ( 2 ) ( EP ( 1 ) agonist ) and sulprostone ( EP ( 1 ) / EP ( 3 ) agonist ) were far more potent than butaprost ( EP ( 2 ) agonist ) and 11 deoxy PGE ( 1 ) ( EP ( 2 ) / EP ( 4 ) agonist ) in inducing c fos and c jun mRNA expressions . ^^^ Since MC3T3 E 1 cells do not express the EP ( 3 ) subtype , these results suggest that PGE ( 2 ) induces c fos and c jun mRNA expressions through the EP ( 1 ) subtype of its receptor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to expressions of c fos and c jun products and bone matrix proteins : a clinicopathologic review and immunohistochemical study of c fos , c jun , type 1 collagen , osteonectin , osteopontin , and osteocalcin . ^^^ From among these cases , the immunohistochemical expressions of c fos and c jun proto oncogene products and bone matrix proteins of type 1 collagen , osteonectin , osteopontin , and osteocalcin were evaluated in 20 typical fibrous dysplasias and 17 osteofibrous dysplasias using paraffin sections , and these expressions were then assessed semiquantitatively . ^^^ Almost all of the cases of fibrous dysplasia and osteofibrous dysplasia showed positive expressions of c fos and c jun products . ^^^ Fibrous dysplasia and osteofibrous dysplasia share some similar histological features , including c fos and c jun expressions , although different clinicohistologic features and immunohistochemical expressions of osteonectin and osteocalcin were observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 activity is negatively regulated by cannabinol through inhibition of its protein components , c fos and c jun . ^^^ In these studies , the regulation of AP 1 activity , with emphasis on c fos and c jun regulation , was investigated using cannabinol ( CBN ) in primary mouse splenocytes in vitro . ^^^ AP 1 activity is negatively regulated by cannabinol through inhibition of its protein components , c fos and c jun . ^^^ This inhibition of binding was , in part , due to decreased nuclear expression of c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Significantly lower DNA binding and protein expression of JunD were detected in P cells than in P+ cells . c Jun was detected in P+ , but not P , AP 1 DNA complexes , and c Fos was detected in P , but not P+ , AP 1 DNA complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study investigated the effect of clonidine on the basal and inducible c jun and c fos mRNA expression in the nucleus tractus solitarius ( middle , mNTS , and rostral , rNTS ) and the rostral ventrolateral medulla ( caudal , cRVLM , and rostral , rRVLM ) . ^^^ Under basal conditions ( saline infused rats ) , c jun mRNA was expressed in the mNTS and rRVLM but not in the rNTS or cRVLM whereas c fos mRNA was not detectable . ^^^ Clonidine attenuated the increases in c fos in the mNTS and cRVLM and c jun gene expression in the mNTS and rRVLM caused by NP evoked hypotension and also reduced the basal expression of c jun mRNA in the mNTS and rRVLM . ^^^ These findings establish a causal link between clonidine inhibition of c fos expression in brainstem and its hypotensive action , and provide the first evidence that clonidine attenuates the expression of the closely linked c jun gene in neurons implicated in centrally mediated hypotension . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Benign and malignant specimens were subjected to Northern blot analysis to evaluate levels of expression of c fos , c jun , and jun B mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Examples of these important proteins include the tumor suppressor protein p 53 , various cyclins , the cyclin dependent kinase inhibitor p 27 , NFkappaB , IkappaB , c fos , and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Significant increases in the levels of c fos , c jun , and egr 1 but not NGFIB mRNA were observed in PC 12 cells exposed to lead or phorbol 12 myristate 13 acetate . ^^^ In contrast , PC 12 cells depolarized with 56 mM K+ displayed an increase in c fos , egr 1 , and NGFIB but not c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The observed changes were correlated with the expression of the mRNA of hsp 70 , c fos , c jun , and junB , as well as the distribution of DNA double strand breaks visualized by terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labelling ( TUNEL ) . ^^^ Expression of the immediate early genes c jun , c fos , and junB increased both in the penumbra and the periinfarct normal tissue already at 1 hour after vascular occlusion , with slightly different regional and temporal patterns for each of these genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NF kappaB and AP 1 activities ; mucosal p 105 , p 50 , and inhibitor kappaB alpha ( IkappaB alpha ) levels ; and c fos , neurotensin , and ferritin H expression were determined by electrophoretic mobility shift assay and Western and Northern analyses , respectively . ^^^ The activated AP 1 contained c fos but not c jun , fosB , and Fra 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously shown that insulin like growth factor 1 ( IGF 1 ) induces the expression of latent transforming growth factor beta 1 ( LTGF beta 1 ) through activation of c fos and c jun oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of immediate early genes c fos and c jun precedes the synthesis , glycosylation , and redistribution , > 4 hr downstream , of a number of synaptic membrane proteins , notably NCAM and L 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of immediate early gene , c fos , and c jun in the rat small intestine after ischemia / reperfusion . ^^^ METHODS : We examined a sequential expression of c fos and c jun after I / R in rat small intestine using reverse transcription polymerase chain reaction and Northern blot analysis , and compared the patterns with coexistent two parameters : ( 1 ) regeneration determined by immunohistochemical detection of proliferating cell nuclear antigen , ( 2 ) programmed cell death determined with the terminal deoxynucleotidyltransferase mediated dUTP biotin nick end labeling ( TUNEL ) method and DNA fragmentation . ^^^ RESULTS : The expression of c fos and c jun mRNA increased markedly 15 min after reperfusion and was , respectively , 6 . 3 and 4 . 4 times higher than in controls . ^^^ Apoptosis after I / R was detected in the nuclei of absorptive epithelial cells by the TUNEL method , and these apoptotic signals were consistent with the expression of c Fos and c Jun proteins using an immunohistochemical method . ^^^ CONCLUSIONS : These results suggest that overexpression of c fos and c jun after I / R in the small intestine correlates with programmed cell death and subsequent cellular regeneration . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Unmanipulated early growth response 1 ( Egr 1 ) deficient / mice have similar heart to body weight ratios but express lower amounts of atrial natriuretic factor ( ANF ) , beta myosin heavy chain ( beta MHC ) , skeletal actin , NGF 1 A binding protein ( NAB ) 2 , Sp 1 , c fos , c jun , GATA 4 , and Nkx2 . 5 than + / + or + / mice . alpha MHC , tubulin , and NAB 1 expression was similar . ^^^ Isoproterenol ( Iso ) and phenylephrine ( PE ) infusion into + / + and / mice increased heart weight , ANF , beta MHC , skeletal actin , Sp 1 , NAB 2 , c fos , and c jun expression , but induction in / mice was lower . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate this possibility , we examined the capacity of continuous treatments with etoposide ( 10 microM ) and camptothecin ( 0 . 4 microM ) , and pulse treatments with 10 rays ( 20 Gy ) , heat ( 2 h at 42 . 5 C ) and cadmium chloride ( 2 h at 200 microM ) followed by recovery , to provoke apoptosis and to simulate c jun and c fos expression and AP 1 binding in U 937 human promonocytic cells . ^^^ However , the capacity to increase c jun and c fos mRNA levels and to stimulate AP 1 binding was very different , ranging from more than a twelve fold increase in the case of cadmium , to almost no increase in the case of heat shock and etoposide . ^^^ However , cAMP greatly stimulated c jun and c fos expression and AP 1 binding when applied together with etoposide ( which itself was ineffective ) , and potentiated the cadmium induced AP 1 binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , okadaic acid treatment resulted in the activation of ERK 2 ( p 42 MAP kinase ) and the induction of both c Jun and c Fos proteins without activating JNK ( c Jun NH 2 terminal kinase ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Non toxic concentrations of anisomycin were found to stimulate these enzyme activities as well as the expression of the early response genes c jun , c fos and zif 268 , and to inhibit NGF induced neurite formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein levels of cell cycle control genes cyclin D 1 , cdk 2 , and E2F 1 are increased in these adenocarcinomas . c Fos protein levels are slightly increased in these cancers , while c Jun levels do not change . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cotransfection of AP 1 expression vectors ( c Fos plus c Jun ) with c met promoter constructs resulted in stimulation of c met promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of the c fos enhancer by the erk MAP kinase pathway through two sequence elements : the c fos AP 1 and p62TCF sites . ^^^ On the 3 ' side of the SRE is the ' c fos AP 1 site ' ( FAP 1 ) whose role has been less clear . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ASMC and PAC 1 cells but not A 10 showed a decrease in c fos mRNA in response to 1 microgram / ml heparin , and a decrease in the c Fos content of AP 1 DNA binding activity . ^^^ CONCLUSIONS : Smooth muscle cell lines show different responses to the antimitogenic effects of heparin that correlate with the heparin sensitivity of c Fos / c Jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Parallel studies demonstrated that the expression of the AP 1 transcription factor c fos , which interacts with the cyclin A promoter and stimulates VSMC proliferation , was also increased in old VSMCs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
P ( GFLG ) DOX effectively killed both types of tumors inducing apoptosis and necrosis through the activation of p 53 , Apaf 1 , caspase 9 , c fos , or c jun pathways , and the downregulation of the bcl 2 gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
At low concentrations , these chemicals may activate the MAPK ( ERK 2 , JNK 1 , p 38 ) leading to gene expression of survival genes ( c Fos , c Jun ) and defensive genes ( Phase 2 detoxifying enzymes ; GST , QR ) resulting in survival and protective mechanisms ( homeostasis response ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 DNA binding activity increased 7 and 14 days after surgery , but it was reduced below C values at day 60 . c fos and c jun expression were also reduced in Nx rats at day 60 . ^^^ AP 1 DNA binding activity increased 7 and 14 days after surgery , but it was reduced below C values at day 60 . c fos and c jun expression were also reduced in Nx rats at day 60 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined if the induction of immediate early gene ( c fos , c myc , c jun , and junB ) and HSP 70 mRNAs by ischemia is affected by ischemic preconditioning . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interaction between the serotoninergic and dopaminergic systems in d fenfluramine induced activation of c fos and jun B genes in rat striatal neurons . ^^^ Our results demonstrated that d fenfluramine evokes nuclear expression of Fos / Jun B proteins in the striatum , and that the Fos expression was dose dependent and accompanied by transient induction of c fos mRNA . ^^^ These results suggest that the mechanism by which d fenfluramine induces c fos and jun B expression in the rat caudoputamen depends at least in part on activation of the dopaminergic system by serotonin . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results indicate that trc S activates rous sarcoma virus long terminal repeat ( LTR ) , human T lymphotropic virus 2 LTR , human immunodeficiency virus 1 LTR , and the c jun and c fos promoters . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
H . pylori strains that do not express CagA or that are mutated in cag genes encoded by the CagI pathogenicity island do not induce activator protein 1 , MAP kinase activity , or c fos or c jun activation . ^^^ Helicobacter pylori activates mitogen activated protein kinase cascades and induces expression of the proto oncogenes c fos and c jun . ^^^ Activation of the proto oncogenes c fos and c jun is strongly induced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Therefore , at higher concentrations of c Jun , gamma GCS gene expression is repressed , presumably due to generation of a sufficient amount of c Jun + c Fos complex that interferes with the binding of Nrf 2 + c Jun complex to the ARE . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Angiotensin 2 also increased the expression of c fos and c jun mRNA , and antisense oligonucleotides against c Fos blocked the AII induced VEGF mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , since the truncated AP 1 used in this study only has the bZip regions of c Jun and c Fos , it appears that the inhibitory action site of momordin 1 may be the basic region of c Jun instead of on the same region of c Fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Substantial nuclear immunostaining was commonly apparent , indicative of an activated c jun pool , with associations with MAP kinase signalling elements , e . g . , transforming growth factor alpha ( p = 0 . 04 ) , epidermal growth factor receptor ( p = 0 . 08 ) , phosphorylated erk 1 / 2 MAP kinase ( p = 0 . 001 ) and phosphorylated jun kinase ( p = 0 . 05 ) Little association was noted with c fos protein , perhaps indicating alternative AP 1 partners for c jun with a diversity of cellular end points . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is the regulatory subunit of the DNA dependent protein kinase that phosphorylates many proteins , including SV 40 large T antigen , p 53 , RNA polymerase 2 , RP A , topoisomerases , hsp 90 , and many transcription factors such as c Jun , c Fos , oct 1 , sp 1 , c Myc , TFIID , and many more . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Maximal expression was observed at 1 h for c fos and TNF alpha mRNAs , at 3 h for c jun and IL 6 mRNAs , and at 6 h for IL 1 beta mRNA , and these signals were virtually nondetectable after 6 12 h from the onset of the injury . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis using an antibody against c Fos protein demonstrated that enhancement of AP 1 / DNA binding was at least in part due to the expression of c Fos protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cell death and immunohistochemistry of p 53 , c Fos and c Jun after spermine injection into the rat striatum . ^^^ The patterns of p 53 , c Fos and c Jun protein expression were determined using immunohistochemistry . ^^^ The number of p 53 immunoreactive cells increased up to 14 h and returned to basal levels by 24 h . c Fos protein expression transiently increased , peaking at 8 h after injection . c Jun exhibited a protracted pattern of expression , remaining elevated up to 24 h . p 53 protein expression was colocalised with TUNEL staining in areas away from the needle tract , but not in cells at the needle tract , suggesting once again a differential mechanism of cell death . ^^^ At 14 h , c Fos and c Jun were not colocalised with TUNEL staining , suggesting that they are either not involved with the cell death process or that the time course of protein expression and the onset of DNA fragmentation do not overlap . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recently , aldosterone was also shown to act on transcription factors in A 6 epithelia : It down regulates the mRNAs of the proliferation promoting c Myc , c Jun , and c Fos by a post transcriptional mechanism , whereas it up regulates that of Fra 2 ( c Fos antagonist ) at the transcriptional level . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , AA also increased several AP 1 proteins , such as c Fos , Fra 1 , Fra 2 , JunB , JunD , and c Jun , or AP 1 and ENKCRE 2 DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the immediate early genes c Fos and c Jun after head injury in man . ^^^ To examine this further we hypothesized that expression of c Fos and c Jun occurs after contusional head injury in man . ^^^ Expression of c fos and c jun mRNA was observed in 50 % and 64 % of head injured patients respectively . ^^^ The expression of c Fos and c Jun was associated with final outcome . ^^^ Patients with poorer outcomes had higher levels of gene expression ( p = 0 . 08 for c Fos and p = 0 . 006 for c Jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We identified AP 1 factors c Fos and JunB as MFNLP binding proteins , whose binding is abolished by introducing point mutations in the 3 ' half of the MFNLP sequence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A further analysis of the two major subunits of AP 1 ( c fos and c jun ) revealed a selective up regulation of c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since TGF beta 1 pretreatment inhibited LPS stimulated expression of c fos and c jun genes and also the binding of nuclear proteins to the consensus sequence of the binding site for activation protein 1 ( AP 1 ) , a heterodimer of c Fos and c Jun , in the cells , TGF beta 1 inhibition of CD 14 expression may be a consequence of downregulation of AP 1 . ^^^ LPS stimulated expression of CD 14 was dramatically inhibited by addition of antisense , but not sense , c fos and c jun oligonucleotides . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , we show that TGF beta 1 increases c jun RNA levels and induces the formation of new complexes involving c jun , fra 2 , ATF 1 , and c fos , which react with Enhancer A and the DRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nicotine slightly increased both c fos and c jun mRNA level and GTS , which did not affect the basal c fos and c jun mRNA expression , further enhanced nicotine induced c fos and c jun mRNA level at both VTA and NA regions . ^^^ GTS may exert an potentiative effect on both c fos and c jun mRNA expression at NA region through inhibiting the release of DA in NA . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with these results , the C terminal region of SMRT directly interacted with SRF , the AP 1 components c Jun and c Fos , and the NFkappaB components p 50 and p 65 , as demonstrated by the yeast and mammalian two hybrid tests as well as the glutathione S transferase pull down assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ATF 2 related transcription factor CRE binding protein contributes to the activity of the cyclin A CRE in chondrocytes , whereas c Jun and c Fos regulate the promoter independently of the CRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CRE binding studies suggested that the CRE complex consisted of CRE binding protein and EGF ERK dependent recruitment of c Jun c Fos ( AP 1 ) to the CRE . ^^^ A dominant negative form of c Fos ( A Fos ) that specifically disrupts c Jun c Fos DNA binding inhibited synergistic activation of the alpha subunit . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mutation of either the activator protein 1 or the runt domain binding site resulted in the inability of c Fos and c Jun or core binding factor a 1 to increase collagenase 3 promoter activity , suggesting that there is cooperative interaction between the sites and the proteins . ^^^ Overexpression of both c Fos and c Jun in osteoblasts or core binding factor a 1 increased collagenase 3 promoter activity . ^^^ Furthermore , overexpression of c Fos , c Jun , and core binding factor a 1 synergistically increased collagenase 3 promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reactions were performed on total RNA from samples of the brain , heart , liver , and kidney to detect the expressions of c fos and c jun mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the first hour of biaxially applied static stretch , the changes in expression of immediate early genes , such as c fos , c jun and fra 1 , were quantified . ^^^ In stretched myocytes , expression of c fos and ANP increased transiently to 227 % and 176 % respectively after 30 min stretch , whereas c jun and fra 1 expression decreased in the 1st hour of stretch . ^^^ In stretched fibroblasts the expression of c fos and fra 1 increased transiently to maxima of 145 % and 146 % respectively after 30 min stretch , whereas c jun expression did not change significantly . ^^^ CM from stretched myocytes reduced c fos and induced c jun expression in myocytes and fibroblasts , reduced fra 1 expression in myocytes but induced fra 1 expression in fibroblasts . ^^^ CM from stretched fibroblasts induced c fos expression and had little effect on c jun expression in myocytes and fibroblasts , induced the fra 1 expression in myocytes but had little effect on fra 1 expression in fibroblasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Some examples include the activation of IEGs , such as c jun and c fos , the phosphorylation of the transcription factor CREB , and the importance of the serum response element and the serum response factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
H ( 2 ) O ( 2 ) + Fe ( 2+ ) treatment resulted in a time dependent increase in the steady state level of c myc mRNA while c jun and c fos were not activated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
GnRH induced induction and activation of the JNK target c Jun was inhibited after chelation of intracellular calcium , whereas induction of c Fos , a known target of ERK , was unaffected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PGE 2 also stimulated activation of AP 1 , a heterodimer of c Jun and c Fos , because the prostanoid increased specific binding of nuclear proteins to the AP 1 consensus sequence and stimulated AP 1 promoted luciferase activity . ^^^ PGE 2 stimulated expression of CD 14 was inhibited by antisense c fos and c jun oligonucleotides , but not by their sense oligonucleotides . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The data obtained demonstrate that the growth factor activity of PAs is associated with : a rapid transient activation of early response genes , c fos , c jun and c myc ; the subsequent coordinated down regulation of p 53 and p21CIP1 ; the constant expression of the MEK 1 mRNA in every phase of the cell cycle . ^^^ Quiescent ( G 0 ) cells did not express c fos , c jun , c myc and cyclin A , but upon stimulation with mitogens ( fetal calf serum ( FCS ) , u PA , t PA ) the cyclin A mRNA expression was observed in concomitance with the activation of DNA synthesis . ^^^ Therefore u PA , t PA and FCS similarly modulate the expression of c fos , c jun , c myc , p 53 , p21CIP1 and cyclin A with only slight differences likely related to the time required for activation of DNA synthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have now shown that expression of both c jun and c fos ( AP 1 ) family of transcription factors is modulated by short and long wavelength solar ultraviolet ( UV ) radiation in human fibroblasts and human KB cells . ^^^ Modulation of c jun and c fos transcription by UVB and UVA radiations in human dermal fibroblasts and KB cells . ^^^ UVA radiation activated c jun and c fos in both fibroblasts and KB cells , whereas ultraviolet B ( UVB ) radiation activates such oncogenes only in KB cells . ^^^ Moreover , decreasing the intracellular levels of reducing equivalents in human fibroblasts by glutathione ( GSH ) depletion lowered the UVA dose threshold for c jun and c fos activation several fold and greatly amplified the UVA mediated activation of such genes . ^^^ In both GSH depleted fibroblasts and KB cells , UVB radiation failed to amplify c jun and c fos activation indicating that the oxidative component of UVB plays a minor role in the modulation of such oncogene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of cultured cells to crystals induces expression of cellular proto oncogenes such as c fos , c myc and c jun , by a calcium dependent mechanism , and this response can be blocked by a potential therapeutic compound , phosphocitrate . ^^^ Activation of the c fos and c jun genes is directly involved in expression of metalloproteinases such as collagenase and stromelysin , suggesting that crystal mediated activation of these genes is directly involved in pathogenesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We used single cell techniques ( patch clamp , videomicroscopy and immunocytochemistry ) to clarify some of the specific aspects of S 100 induced apoptosis , the modality ( ies ) of early intracellular Ca2+ concentration increase and the expression of some classes of genes ( c fos , c jun , bax , bcl 10 , p 15 , p 21 ) known to be implicated in apoptosis of different cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , it induced the expression of c Fos , c Jun , and HSP 70 in a time dependent manner in SMC . ^^^ These results also suggest that enhanced eIF4E phosphorylation by H ( 2 ) O ( 2 ) appears to be an important event in SMC in response to oxidant stress and that eIF4E phosphorylation may be associated with the translation of a small subset of mRNAs such as c fos , c jun , and HSP 70 gene mRNAs , whose products may have a critical role in cell survival . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The entire extracellular domain of the GHR was replaced by the hemagglutinin tagged zipper sequence of either the c Fos or c Jun transcription factor ( termed Fos GHR and Jun GHR , respectively ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP 1 site by c Jun , JunB , JunD , c Fos , FosB , and Fra 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TGFalpha mRNA expression was shifted together with the DNA synthesis , but the expression of c myc , c fos , c jun , HGF , TGFbeta 1 , IL1beta did not delay . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Even 2 3 fold overexpression of p202a in cells retards proliferation . p202a was shown to modulate transcription by binding , and inhibiting the activity of several transcription factors including c Fos , c Jun , AP 2 , E2F1 , E2F4 , NF kappaB , MyoD , and myogenin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The human histamine H ( 2 ) receptor regulates c jun and c fos in a differential manner . ^^^ The protein kinase C ( PKC ) inhibitors staurosporine ( 10 ( 6 ) M ) and GF 109203X ( 10 ( 6 ) M ) significantly inhibited histamine stimulated c fos mRNA while not altering c jun expression . ^^^ The protein kinase A ( PKA ) pathway inhibitors Rp cAMP and protein kinase inhibitor did not affect the action of histamine on c jun or c fos mRNA . ^^^ The specific inhibitor of the mitogen activated protein ( MAP ) kinase pathway , PD 98059 ( 5 10 10 ( 5 ) M ) , significantly inhibited histamine induced c fos and c jun mRNA . ^^^ Of interest , the p 70 S6 kinase inhibitor rapamycin ( 10 ( 6 ) M ) but not wortmannin decreased histamine stimulated c jun mRNA by 58 . 5 + / 12 % ( mean + / SE , n = 4 ) while not significantly altering c fos message . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the proto oncogenes c fos , c jun , c ha ras and c myc was studied in in vivo grown and in vitro cultured bovine preimplantation blastocysts employing RT PCR , ribonuclease protection assay and immunohistochemistry . ^^^ In in vivo grown blastocysts c fos , c jun and c ha ras transcripts as well as c Fos , c Jun and c Myc proteins were detected in all stages studied . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cervical carcinoma cell lines were either negative or expressed only low amounts of Fra 1 ( jointly with c Fos ) within their AP 1 complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On electrophoretic mobility shift analysis ( EMSA ) , PMA induces binding to a PGHS 2 probe spanning this sequence , binding is blocked by an unlabeled AP 1 canonical sequence , and antibodies specific for c Jun and c Fos inhibit binding . ^^^ On EMSA , serum induces binding to a PGHS 2 probe spanning the AP 1 site , binding is blocked by an unlabeled AP 1 canonical sequence , and antibodies specific for c Jun and c Fos inhibit binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , the expression of JunB , c jun and c fos , but not JunD , was increased by LPS , TNF alpha , IFN gamma and IL 1 , albeit with different kinetics and magnitude of induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Second , ASC 2 specifically interacted with the activating protein 1 ( AP 1 ) components c Jun and c Fos as well as the nuclear factor kappaB ( NFkappaB ) components p 50 and p 65 , as demonstrated by the glutathione S transferase pull down assays as well as the yeast two hybrid tests . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of these receptors stimulates several linked responses , including cAMP formation and induction of c Fos and c Jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using anti sense c fos strategy , we have shown that c fos is essential for the activation of activator protein 1 transcription factor complex ( AP 1 ) and subsequent stimulation of downstream genes such as tyrosine hydroxylase ( TH ; Mishra et al . 1998 ) . ^^^ Intracellular pathways linking hypoxia to activation of c fos and AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Whilst the expression of JunD was not affected by any of the mediators , the mRNA levels of c fos and JunB were induced by LPS , IL 6 , IFN gamma , PDGF and TNF alpha , and that of c jun by LPS , IFN gamma , PDGF and TNF alpha . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The age related activation of AP 1 and NF kappaB in the gastric mucosa was associated with increased levels of c Jun , c Fos , and p 52 , but not p 50 or p 65 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EM field exposures induced significant increases in protein levels for hsp 70 and c Fos and in AP 1 binding activity . ^^^ Cells treated with the phorbol ester , TPA , served as positive controls for AP 1 activation , c Fos protein synthesis , and ERK1 / 2 phosphorylation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To dissect the mechanism of these effects , we measured c Jun and c Fos expression , and the activity of c Jun NH 2 terminal kinase ( JNK ) and extracellular signal regulated kinase ( ERK ) in human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In a transient transfection assay , all three RAR subtypes , RARalpha , RARbeta , and RARgamma , could effectively inhibit phorbol ester 12 O tetradecanoylphorbol 13 acetate induced AP 1 activity and the activity of oncogenes c Jun and c Fos on AP 1 containing reporter genes in the presence of retinoic acid ( RA ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The data , in combination with our previous results [ Takeuchi J . et al . ( 1993 ) Neuron 11 , 825 836 ] , suggest that activator protein 1 binding sites on ventrolateral suprachiasmatic nucleus target genes are constitutively occupied by DeltaFosB / JunD complexes , and that c Fos , Fra 2 , FosB and JunB compete for binding after photic stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , an increase in HO 1 mRNA level that was detected as early as 2 hrs . following SNP treatment preceded c jun and c fos induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the effects of tumor necrosis factor ( TNF ) alpha , a potent proinflammatory cytokine , on cultured human ASM cells by examining the expression and release of the cytokine interleukin ( IL ) 6 , cell proliferation , and the expression pattern of c fos and c jun , two nuclear proto oncogenes constituting the activator protein 1 transcription factor . ^^^ Northern blot analysis of proto oncogene expression revealed that c fos and c jun mRNA levels were elevated after 30 min of TNF alpha incubation with maximum levels at 1 h and 45 min , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Valsartan prevented monocyte / macrophage infiltration , nuclear factor kappaB ( NF kappaB ) and activator protein 1 ( AP 1 ) activation , and c fos expression in dTGR hearts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A c fos / Estrogen receptor fusion protein promotes cell cycle progression and proliferation of human cancer cell lines . c fos is the prototypic member of a family of transcription factors that regulate many cellular processes , including proliferation . c fos heterodimerizes with jun family members to form the AP 1 transcription factor complex which binds specific DNA recognition elements in the promoters of many genes . ^^^ We concluded that activation of c fosER mediated transcriptional inhibition of p 21 ( Cip1 / WAF1 ) through a previously uncharacterized AP 1 site , revealing an important role for c fos in negative control of cell cycle regulatory genes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phosphoacetylation of histone H 3 on c fos and c jun associated nucleosomes upon gene activation . ^^^ The induction of immediate early ( IE ) genes , including proto oncogenes c fos and c jun , correlates well with a nucleosomal response , the phosphorylation of histone H 3 and HMG 14 mediated via extracellular signal regulated kinase or p 38 MAP kinase cascades . ^^^ Analysis of the associated DNA shows that histone H 3 on c fos and c jun associated nucleosomes becomes doubly modified , the same H 3 tails becoming both phosphorylated and acetylated , only upon gene activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , we tested the hypothesis that c jun and c fos are regulated differentially by shear and pressure . ^^^ Shear stress and pressure exert differential temporal effects on c jun and c fos gene and protein expression , and these immediate early gene responses appear to be cell type specific for endothelial and smooth muscle cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential effects of cholera toxin and pertussis toxin on the c fos and c jun mRNA expression in rat C 6 glioma cells . ^^^ Cholera toxin ( CTX ) increased c fos mRNA level whereas it down regulated the c jun mRNA level in rat C 6 glioma cells . ^^^ In contrast to the action of CTX , pertussis toxin ( PTX ) did not affect either c fos or c jun mRNA level . ^^^ Cycloheximide ( CHX ) increased c fos and c jun mRNA levels . ^^^ Our results suggest that CTX , but not PTX , sensitive G proteins may play an important role for c fos mRNA up regulation and c jun mRNA down regulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The increases of proENK and proDYN mRNA levels induced by KA were well correlated with the increases of c Fos , Fra 2 , FosB , c Jun , and JunB protein levels , which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These are three single stranded DNA binding proteins , YB 1 , Puralpha and Purbeta and two components of the AP 1 complex , c Fos and c Jun . c Jun is a potent transcriptional activator of fas and stimulated expression levels up to 184 fold in reporter gene assays . ^^^ Co expression with c Fos abrogated c Jun mediated activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neuroprotective agent chlomethiazole attenuates c fos , c jun , and AP 1 activation through inhibition of p 38 MAP kinase . ^^^ The inhibition of p 38 MAP kinase resulted in the attenuation of the induction of c fos and c jun mRNA and AP 1 DNA binding by lipopolysaccharide ( LPS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gene expression studies using RNase protection assays , reverse transcription PCR , and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth , such as c fos , c jun , and EGR 1 , as well as cell arrest , such as GADD 153 and GADD 45 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays revealed that antibodies to c Fos , Fos B , Fra 2 , c Jun , Jun B , and Jun D shifted the binding of nuclear extracts from cells treated with PDGF BB to AP 1 sequences . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also observed increased expression of mRNAs for Fos and Jun transcription factor family members c Fos , FosB , Fra 2 , and JunB , as well as Fos family proteins in the entorhinal cortex after MK 801 administration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PURPOSE : To detect the expression of mRNA of protooncogenes ets 1 , c jun , c fos , and platelet derived growth factor ( PDGF ) in proliferative membranes of patients with proliferative diabetic retinopathy ( PDR ) and proliferative vitreoretinopathy ( PVR ) . ^^^ Ets 1 , c jun , c fos , PDGF A , and PDGF B cDNA were amplified using reverse transcriptase polymerase chain reaction ( PCR ) . ^^^ CONCLUSIONS : Our results suggest that not only PDGF mRNA was expressed in the membranes of patients with PDR and PVR , but proto oncogenes ets 1 , c jun , and c fos mRNA were also expressed . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the other hand , c fos combined with any of the Jun related proteins failed to stimulate the TIMP 1 promoter , although it was activated by Fra 1 or Fra 2 / Jun related protein heterocomplexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Biochemical ( serum transaminase and hepatic GSH levels ) and molecular ( c jun and c fos messenger RNA [ mRNA ] levels and activator protein 1 [ AP 1 ] DNA binding activity ) parameters were measured , as well as the consequent effects on gamma GCS levels and activity . ^^^ DEM , APAP , and CCl ( 4 ) increased c jun and c fos mRNA levels , together with an increase in AP 1 binding ; BSO failed to induce AP 1 despite an increase in c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The SPP stimulation was activation protein 1 ( AP 1 ) dependent , because the SPP stimulatory action toward these nuclear gene expressions and the transient CAT activity were inhibited by antisense c fos and c jun oligonucleotides . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^ After Western blot analysis , we found significant associations between members of both groups : whereas c jun was associated with Rb expression ( p = 0 . 002 ) , strong junD and c fos expression correlated with high cyclin E reactivity ( p = 0 . 017 and p = 0 . 013 , respectively ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This requires the rapid entry of c Fos into specific AP 1 DNA binding complexes and can be strongly inhibited by the adenovirus EIA 12S gene product . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Estradiol stimulation of c fos and c jun expressions and activator protein 1 deoxyribonucleic acid binding activity in rat white adipocyte . ^^^ In order to elucidate the molecular mechanisms whereby ovarian hormones , and particularly estrogens , modulate fat cell metabolism , we investigated the effects of estradiol administration on c fos and c jun expressions in fat cells from ovariectomized ( OVX ) rats . ^^^ Estradiol treatment resulted in a rapid increase in c fos and c jun messenger RNA ( mRNA ) and protein levels ( about 2 fold ) . ^^^ These effects of estradiol on c fos and c jun mRNAs were blocked by actinomycin D but not by cycloheximide treatment , suggesting that estradiol modulates c fos and c jun transcription . ^^^ In contrast , progesterone administration did not affect c fos and c jun mRNA levels indicating a hormonal specificity of estrogen action . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of lipopolysaccharide ( LPS ) on the expression of immediate early genes , such as c fos and c jun , was examined in C 6 rat glioma cells . ^^^ Cycloheximide ( CHX , 20 microM ) , a protein synthesis inhibitor , alone caused increases of c fos and c jun mRNA levels . ^^^ LPS showed a potentiating effect in the regulation of c fos mRNA level , whereas LPS showed an additive action for the regulation of CHX induced c jun mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This type of stimulation led to a specific and statistically significant increase in the expression of the protein products of the inducible transcription factors c Fos , JunB , inducible cyclic AMP early repressor and Krox 24 ( also frequently named Zif 268 or Egr 1 ) , but not c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PI 3 K mediated stabilization of mRNA is not a general phenomenon , since other rapidly regulated and unstable mRNAs , such as those encoding c fos , c jun and c myc , are not stabilized upon activation of the PI 3 K signaling pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that expression of c Fos , c Jun , and JunB was induced upon LIF treatment whereas that of JunD , the tyrosine phosphatase ESP , and the components of the LIF receptor remained unaffected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional inhibition of matrix metalloproteinase 9 ( MMP 9 ) activity by a c fos / estrogen receptor fusion protein is mediated by the proximal AP 1 site of the MMP 9 promoter and correlates with reduced tumor cell invasion . ^^^ To determine how a specific AP 1 family member , c fos , regulates MMP 9 promoter activity through these sites , we used an expression vector containing the c fos coding region fused to the estrogen receptor ( ER ) ligand binding domain . ^^^ We concluded that the proximal AP 1 site mediated the transcriptional downregulation of the MMP 9 promoter by a conditionally activated c fos fusion protein . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This study investigates in perfused pig livers the effect of the antioxidant idebenone and of cold ischemia time on the gene expression of c fos and c jun . ^^^ C fos and c jun mRNA were determined by RT PCR at 3 , 30 , 60 , 120 180 , 210 min during reperfusion . ^^^ C fos and c jun were strongly induced in livers stored for 20 h , which was attenuated by idebenone ( p < 0 . 05 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We previously reported that following acute administration of haloperidol or ( ) sulpiride , both dopamine D ( 2 ) receptor antagonists , to mice induced nerve growth factor ( NGF ) gene expression , mediated by the interaction of c fos with the AP 1 binding site present in the first intron on the NGF gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this paper , we attempted to investigate whether the transcription factors regulating the gene expression of c fos and nNOS , including activator protein 1 ( AP 1 ) , nuclear factor kappa B ( NF kappa B ) , and octamer factors ( Oct ) , are activated by CFA during the development of hyperalgesia . ^^^ Based on these findings , we conclude that AP 1 , NF kappa B and Oct are crucial for the expression of c Fos proteins at an early stage ( at 3 h ) and for the expression of nNOS at a late stage of hyperalgesia ( 48 h post injection ) induced by CFA . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of the immediate early genes c myc , c fos , and c jun by IGF 1 was abolished by preincubation with antisense oligos against PLCbeta 3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
BRCA 1 did not induce the c Jun and c fos promoters , which rules out a general effect of BRCA 1 on other immediate responsive genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As a result , Fra 1 and Fra 2 though efficiently form dimers with the Jun proteins , are weak transcriptional activators and inhibit the c Fos dependent activation in transient transfection assay . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the mechanisms of areca quid ( AQ ) induced carcinogenesis , expression of c fos and c jun protooncogenes was examined in human oral mucosal fibroblasts after exposure to areca nut extracts ( ANE ) or arecoline . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The same pattern was found for c Myc , c Jun , and c Fos proteins , which were elevated by 3 . 2 , 2 . 3 , and 3 . 4 fold , respectively , compared to control animals after 3 weeks . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
GAL 4 Elk1 studies revealed that DEX suppressed TGF beta induced ERK activation which led to c fos gene expression followed by increase in AP 1 complex formation , whereas the Smad pathway was not involved in DEX dependent negative regulation of AP 1 in a reporter assay that requires FAST 1 Smad2 for the activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel mobility shift with a [ ( 32 ) P ] labeled collagenase 3 AP 1 site probe indicated the induction of c Fos in osteoblastic cells upon PTH treatment . ^^^ From our studies above , it is evident that the expression of collagenase 3 and its regulation by PTH in osteoblastic and non osteoblastic cells may be influenced by differential temporal stimulation of the AP 1 family members , especially c Fos and Jun B along with the potential for posttranslational modification ( s ) of Cbfa1 . . ^^^ While c fos was induced in UMR cells , both c fos and jun B were induced in ROS cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , while accumulation of c fos mRNA was observed within 30 min of TBH treatment in vector transfected NIH / neo cells , TBH induced c fos mRNA generation was completely suppressed in NIH / beta1 14 cells , while that of c jun and GAPDH was not affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of ERKs by PD 098059 suppressed induction of c fos without affecting early induction of c jun , leading to attenuated activation of AP 1 in response to H2O2 . ^^^ CONCLUSIONS : These results suggested that ( 1 ) activation of JNK and ERKs , but not p 38 kinase , is required for the H2O2 induced apoptosis ; and ( 2 ) suppression of the JNK c Jun / AP 1 pathway and the ERK c Fos / AP 1 pathway is involved in the anti apoptotic effect of quercetin . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because c fos gene expression plays a critical role in UVB induced AP 1 activation and p 38 is required for UVB induced c fos gene expression in HaCaT cells , as reported previously , a potential UVB signaling cascade for AP 1 activation in human keratinocytes has been determined . ^^^ This cascade involves UVB , p 38 activation , c fos gene expression , and AP 1 activation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This increase of c fos mRNA expression was blocked by PD 98059 ; in addition , curcumin , a blocker of the transcriptional factor AP 1 , canceled the effect of Ang 2 on the collagen 1 gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Once mechanical force is sensed , protein kinase C and mitogen activated protein kinases ( MAPKs ) were activated , leading to increased c fos and c jun gene expression and enhanced transcription factor AP 1 DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
FGF 2 elicits a strong mitogenic response in G0 / G1 arrested Y 1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases mitogen activated protein kinases ( ERK MAPK ) ( 2 to 10 min ) , b ) transcription activation of c fos , c jun and c myc genes ( 10 to 30 min ) , c ) induction of c Fos and c Myc proteins by 1 h and cyclin D 1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h . ^^^ ACTH , itself a weak mitogen , interacts with FGF 2 in a complex manner , blocking the FGF 2 mitogenic response during the early and middle G 1 phase , keeping ERK MAPK activation and c Fos and cyclin D 1 induction at maximal levels , but post transcriptionally inhibiting c Myc expression . c Fos and c Jun proteins are mediators in both the strong and the weak mitogenic responses respectively triggered by FGF 2 and ACTH . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The p 56 ( dok 2 ) overexpressing cells showed an impaired induction of c myc but not of c jun , junB or c fos when stimulated with M CSF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , our data suggested that a change in AP 1 composition , particularly c Fos , was important in mediating GnRHa induced inhibition of human GnRHR gene expression . ^^^ By the use of Western blot analysis , a significant increase in c Jun ( 100 % ; P < 0 . 05 ) and c Fos ( 50 % ; P < 0 . 05 ) protein levels was observed after GnRHa treatment in alphaT 3 1 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression levels of protooncogenes ( as c fos , c jun , and fra 1 ) were measured , and as an indication of a hypertrophic response the expression of atrial natriuretic peptide ( ANP ) was measured . ^^^ In stationary cardiomyocytes , CM derived from stretched cardiomyocytes caused decreased c fos and fra 1 expression by 37 and 20 % , respectively ( CM 30 ) , elevated c jun expression by 20 % ( CM 45 CM60 ) , and increased ANP expression by 106 % ( CM 45 ) . ^^^ CM derived from stretched cardiac fibroblasts caused increased c fos expression by 41 % ( CM 60 ) , no significant changes in c jun expression , and increased fra 1 and ANP expression by 39 and 20 % , respectively ( CM 45 ) . ^^^ CM derived from stretched VSMCs induced an initial decrease in c fos expression followed by an increase of 13 % ( CM 45 ) and induced increased c jun , fra 1 , and ANP expression by 39 , 24 , and 22 % , respectively . ^^^ CM 15 CM60 derived from stretched endothelial cells caused decreased c fos , c jun and fra 1 expression by 20 , 25 , and 25 % , respectively , and increased ANP expression by 18 % . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Like all other bZIP proteins , MEQ is capable of dimerizing with itself and with a variety of bZIP partners including c Jun , B Jun , c Fos , CREB , ATF 1 , ATF 2 , and SNF . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
VEGF induced the activation of activator protein 1 ( AP 1 ) and c fos mRNA expression in human dental pulp cells . ^^^ These results suggest that VEGF produced by human dental pulp cells acts directly upon human dental pulp cells in an autocrine manner , and may promote the chemotaxis , proliferation , and / or differentiation of human dental pulp cells via the utilization of kinase insert domain containing receptor and in part through AP 1 by increasing c fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we revealed that PGA 1 induces c fos expression at least partly by increasing the binding between heat shock factor 1 and the HSE , and that PGA 1 enhances activity of activating protein 1 ( AP 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , using IL 1beta , a proinflammatory and prooxidant cytokine that is increased in numerous pathological situations , cells of astrocytoma cell line U 373 MG were exposed to an oxidative stress , leading to c Jun and c Fos activation . ^^^ We observed that antioxidants inhibit IL 1beta effects on c Jun and c Fos proteins , GGT activity and the GSH pool but not on apoE secretion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Therefore , the role of integrins in osteoblast signaling , leading to the induction of AP 1 transcription factors ( c fos and c jun ) which are important in cell proliferation , was studied . c fos and c jun message levels were increased at 60 min in osteoblasts plated onto fibronectin or collagen , but not in cells on osteonectin or poly L lysine . ^^^ These results demonstrate that osteoblast binding to the extracellular matrix through integrins induces c fos and c jun , and that both fibronectin and collagen affect these AP 1 transcription factors through protein kinase sensitive pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Primary osteoblasts from fetal rat calvaria were plated onto TIV , fibronectin ( FN ) , and poly L lysine ( PLL ) and the levels of focal adhesion kinase ( FAK ) , mitogen activated protein kinase ( MAPK ) , and AP 1 transcription factors , c fos and c jun , were compared by Western and Northern blots . ^^^ On TIV and FN , c fos and c jun mRNA levels were maximal within 1 h and then plateaued or declined by 2 h . ^^^ Within 1 h , c fos protein was stimulated in cells attached to TIV and FN and decreased in cells on PLL . c jun protein increased on all substrates compared to unplated cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , concerning the molecular effects , although p 1 30 alone induces the antiapoptotic molecule bcl 2 , we show that it does not influence mRNA expression of c myc , c jun , and c fos oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^ Most of the antibodies against AP 1 family proteins , except for c Fos specific antibody , labeled ameloblast nuclei . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The stimulation of ml receptors enhanced the PMA / A23187 induced binding activity to AP 1 consensus sequences in IL 2 promoter and production of c Fos and c Jun protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show here that ( 1 ) 5 Jun mediated repression of the endogenous SPARC gene is enhanced by Fra 2 but alleviated by ATF 2 , Fra 2 and ATF 2 being the two major partners of 5 Jun in the transformed cells ; ( 2 ) high basal activity as well as repression by 5 Jun and modulation by Fra 2 and ATF 2 is restricted to a small proximal fragment ( 124 / +16 ) of the chicken SPARC promoter ; ( 3 ) the activity of this minimal promoter is modulated by all the AP 1 family members known in chickens ( c Jun and JunD ; c Fos and Fra 2 ; ATF 2 ; c Maf , MafA , and MafB ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To test the hypothesis that loading conditions can be used to engineer early ligament scar behaviors , we used an in vitro system to examine the effect that cyclic hydrostatic compression and cyclic tension applied to 6 week rabbit medial collateral ligament scars had on mRNA levels for matrix molecules , collagenase , and the proto oncogenes c fos and c jun . ^^^ Semiquantitative reverse transcription polymerase chain reaction analysis was performed for mechanically treated medial collateral ligament scars with use of rabbit specific primer sets for types 1 , 2 , and 3 collagen , decorin , biglycan , fibromodulin , versican , aggrecan , collagenase , c fos , c jun , and a housekeeping gene , glyceraldehyde 3 phosphate dehydrogenase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of IL 1 induced gingival collagenase gene expression by activator protein 1 ( c Fos / c Jun ) . ^^^ In this study , we demonstrate that the concentration of the protein components of AP 1 transcription factor , c Fos and c Jun , is enhanced by IL 1beta both at mRNA and protein levels , utilizing Northern blot analysis , electrophoretic mobility gel shift assay and Western blot analysis . ^^^ Further , overexpression of c Fos and c Jun proteins revealed a dose dependent transcriptional activation of the collagenase promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The gene expression was preceded by 1 ) induction of AP 1 components c fos and c jun and 2 ) phosphorylation of extracellular signal regulated kinase ( ERK ) , p 38 mitogen activated protein ( MAP ) kinase , and c Jun NH ( 2 ) terminal kinase ( JNK ) , the upstream inducers / activators of AP 1 . ^^^ Suppression of ERK by PD 098059 abrogated induction of c fos and c jun , and the p 38 MAP kinase inhibitor SB 203580 attenuated c fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of major significance was the finding that FosB could be detected as a component of AP 1 in 7 DIV cells only under excitotoxic conditions , whereas c Fos , Fra 2 , and JunD proteins were detectable under both excitotoxic and nontoxic conditions in cells of this age . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Through the JNK and p 38 pathways , arsenite activates the immediate early genes c fos , c jun , and egr 1 , usually activated by various growth factors , cytokines , differentiation signals , and DNA damaging agents . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The gene expressions of c jun , c fos , and egr 1 , known as downstream effectors of MAPK , were also investigated . ^^^ Hypoxia upregulated egr 1 mRNA but downregulated c jun and c fos mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transfections of various luciferase reporter constructs in HBC cells revealed involvement of activator protein 1 dependent as well as independent pathways in induction of the c fos gene by OA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion , and on the expression of c fos and c jun in the trigeminal complex of the rat in an experimental migraine model . ^^^ In an experimental migraine model , it has been shown that electrical stimulation of the rat trigeminal ganglion induced an increase in the lengths of CGRP immunoreactive axons , increased size and number of pleomorphic axonal varicosities in the dura mater , and an increased number of c jun and c fos protein expressing nerve cells in the trigeminal complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Structure function analysis as well as studies with knock out and transgenic mice have assigned distinct functions to c Fos and Fra 1 , two components of the transcription factor AP 1 ( activator protein 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , neurons of the SOC in adult mammals respond to various kinds of hearing impairment with the expression of plasticity related substances ( e . g . , GAP 43 , c Jun , c Fos , cytoskeletal elements ) , indicative of a restructuring of auditory connectivity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of alpha ( 1 ) ARs by NVI 085 , or beta ARs by salbutamol , increased cortical NGFI A , c jun and c fos mRNA levels , whereas inhibition of alpha ( 1 ) ARs by prazosin , or beta ARs by propranolol , had no marked effect . ^^^ The alpha ( 2 ) AR agonists , clonidine and UK 14304 also had no effect on basal IEG levels , while blockade of alpha ( 2 ) ARs by methoxyidazoxan significantly increased NGFI A and c fos expression , but decreased c jun mRNA levels . ^^^ Prazosin reduced FCL ( SD ) induced elevations of c jun and c fos , but not NGFI A , mRNA . ^^^ Methoxyidazoxan enhanced NGFI A and c fos mRNA expression after FCL ( SD ) , but reduced c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To understand the mechanism of neuronal apoptosis induced by herpes simplex virus ( HSV ) infection in vivo , the distribution of viral antigen , the appearance of apoptotic bodies , and the expressions of the tumor suppressor gene p 53 and several transcription factors such as c fos , c jun and NF kappaB were examined immunohistochemically and histopathologically after corneal infection of mice with HSV type 2 strain 186 . ^^^ Neuronal apoptosis was observed in the brain stem ipsilateral to the HSV infected side with the immunoreactivities of c fos , c jun , NF kappaB and p 53 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction ( RT PCR ) analysis revealed elevated mRNA expression of transcription factor AP 1 ( c jun and c fos ) and increased AP 1 DNA binding activity as determined by electrophoretic mobility shift assay ( EMSA ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We previously showed that Tax induces the expression of various family members of the transcription factor AP 1 such as c Jun , JunD , c Fos , and Fra 1 at the mRNA level in T cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoblotting analysis of c Fos and a gel mobility assay of AP 1 DNA binding activity supported the decrease in c Fos synthesis in permethrin treated CGCs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Amongst the molecules involved in the early marking of cell damage are the genes c fos and c jun , HSP , MAP 2 , cytokines , GLUT 3 and calpaines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The regulatory pathways involved in the rapid response of the AP 1 transcription factor , c fos , to mechanical load in human primary osteoblast like ( HOB ) cells and the human MG 63 bone cell line were investigated using a four point bending model . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemical study on the expression of c Fos and c Jun in human skin wounds . ^^^ An immunohistochemical study on the temporal expression of c Fos and c Jun , both of which designate proto oncogene products , was performed on 60 human skin wounds with different post infliction intervals . ^^^ In unwounded skin , c Fos or c Jun was immunolocalized at the nuclei of the epidermal cells in the basal layer , hair follicle cells and sweat gland cells . ^^^ During the early inflammatory phase of wound healing , the nuclei of polymorphonuclear cells ( probably neutrophils ) , mainly infiltrating at the wound site , were labeled with anti c Fos or c Jun antibody . ^^^ As the wound age increased , the neutrophils had disappeared at the wound site , and both mononuclear cells ( probably macrophages ) and spindle shaped fibroblastic cells , which expressed a c Fos or c Jun positive reaction in the nuclei , were mainly observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The pattern shifted to c Jun and c Fos ( known AP 1 components ) on GD 13 and 14 . ^^^ In SAD treated offspring , however , CREM 1 alone ; c Jun , c Fos , and CREB ; and c Jun and c Fos bound to TRE on GD 12 , 13 , and 14 , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest that in vivo kainate signals may lead to persistent expression of the transcription factor activator protein 1 that consists of different Fos family members , as well as of c Fos protein phosphorylated on serine and / or tyrosine residues , at an early stage after administration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transduction of cells with 5 rasHa results in increased AP 1 dependent transcriptional activity , which is also simulated by transfection of keratinocytes with either c Fos or deltaFos B but not Fra 1 , suggesting that the up regulation of c Fos and deltaFos B contributes to this effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , LIF activated STAT 3 indirectly mediates LIF corticotroph action by inducing and potentiating CRH induced c fos and JunB expression and binding to the POMC AP 1 element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c jun and c fos in apoptotic cells after DNA damage . ^^^ The protein expression levels of c jun and c fos increased in DNA damaged HeLa cells after MNNG treatment in a time dependent fashion . ^^^ Although the levels of c fos increased rapidly during the first 30 min and remained high for 2 hr , the increase in c jun expression was more gradual and slower ( 60 120 min ) after MNNG treatment . ^^^ These results are consistent with the conclusion that c fos is important in the initial stages ( commitment phase ) of apoptosis and c jun is involved in the late stages ( execution phase ) of apoptosis induced with alkylating agents . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , the levels of transforming growth factor beta ( TGF beta ) , gp 130 , c fos , and c jun transcripts in these cells were consistently and significantly different ( higher ) than in all other populations analyzed , including phenotypically similar but biologically different cells from fetal or neonatal sources , as well as adult BM CD 34 ( + ) cells still in G ( 0 ) after 2 days of growth factor stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Human PTH ( 1 34 ) and hPTH ( 1 84 ) increased steady state mRNA expression of c jun , junB , c fos , and fra 2 in an equivalent dose and time dependent manner . ^^^ Expression of c jun , junB , and c fos peaked 30 minutes after the injection while fra 2 expression peaked 30 minutes later . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Atopic dermatitis keratinocyte nuclear lysates had higher constitutive levels of c Jun , and phorbol myristate acetate promoted an earlier and stronger expression of c Jun , JunB , and of the phosphorylated forms of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , HF and HG perfusion had no effect on Na ( + ) dependent glucose transporter ( SGLT 1 ) expression but increased c fos and c jun expression . ^^^ Actinomycin D also prevented the perfusion induced increase in c fos and c jun mRNA abundance but did not affect glucose uptake rate and SGLT 1 mRNA abundance . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In ROS 17 / 2 . 8 cells , TGF beta 1 as well as BMP 2 up regulated the expression of junB and c fos messenger RNAs ( mRNAs ) , and this increase was correlated in both cases with an increase in activator protein 1 ( AP 1 ) DNA binding activity involving JunB and c Fos proteins . ^^^ In osteoblastic cells , transforming growth factor beta 1 ( TGF beta 1 ) has been found to regulate the expression of a variety of proto oncogenes including c fos , c jun , and junB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have used thapsigargin ( TG ) , an ER calcium ATPase pump inhibitor that induces calcium release from the ER , to investigate the possible involvement of c Fos , a component of the AP 1 transcription factor , in grp 78 induction . ^^^ C FosdeltaC , a proteasome resistant c Fos mutant with AP 1 activity similar to that of wild type c Fos , restores grp 78 induction in WEHI7 . 2 cells , detected by both Northern hybridization and a grp 78 promoter luciferase reporter assay . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of membrane bound TNFalpha was also found in c fos gene knockout mice deficient in the AP 1 transcription factor , suggesting that , although AP 1 containing c fos signaling is required for some UV responses , AP 1 containing c fos is not required for this TNFalpha activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increases occurred in oxidative stress responsive genes HO 1 , QR , HSP 70 , GADD 45 , GADD 153 , p 21 ( WAF1 / CIP16 ) , GST ' s , GAPDH , TPX , and GPX 1 ( 0 ) ; transcriptional regulators c jun , c fos , jun B , c myc , and IkappaB ; protein repair components Rdelta , RC 10 2 , C 3 , RC 7 , HR6B ubiquitin conjugating enzyme and ubiquitin ; DNA repair components PCNA , msh 2 , and O 6 methylguanine DNA methyltransferase ; lipid peroxide excision enzyme PLA 2 ; and apoptogenic components TNFalpha , iNOS 1 and FasL . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the effects of these doses of beta carotene on retinoid concentrations , expression of retinoic acid receptors ( RARs ) , activator protein 1 ( AP 1 ; c Jun and c Fos ) , cyclin D 1 , proliferating cellular nuclear antigen ( PCNA ) , and histopathological changes in the lungs of both normal and cigarette smoke exposed ferrets . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CONCLUSIONS : Expression of c fos and c jun mRNA is transiently induced by exposure to damaging light . ^^^ Induced expression of c jun persists longer than expression of c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Human T cell leukemia virus type 1 ( HTLV 1 ) Tax protein induces the expression of various family members of the transcription factor AP 1 , such as c Jun , JunD , c Fos , and Fra 1 , at the level of RNA expression in T cells . ^^^ Activation of transcription through the AP 1 site in Jurkat cells by JunD and / or Fra 2 was weak . c Jun , JunB , and c Fos activation was greater , although the level was still less than that with Tax . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Addition of the peptides to the insulin secreting betaTC 3 cell line results in a marked inhibition of IL 1beta induced c jun and c fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c Myc , c Fos , and c jun in hepatocellular carcinoma . ^^^ The proto oncogenes c fos and c jun are involved in cell cycle progression and cellular proliferation . ^^^ METHODS : The objective of this study was to elucidate the mechanism of hepatocarcinogenesis with regard to the expressions of c myc , c fos , and c jun . ^^^ There was a trend toward a positive association between the expression of c fos and the expression of c jun in tumor tissue ( P = 0 . 07 ; r = 0 . 162 ) . ^^^ The coordinated expression of c fos and c jun in HCC may reflect the coordinated tumor cell cycle of progression and proliferation ; however , future studies are required to elucidate this possibility . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The significant increase in c jun levels along with our earlier observation on the increased c fos levels indicate that AP 1 family of genes may be one of the IEGs involved in the long term changes which eventually lead to OPIDN . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In fact , the fimbriae induced markedly both the expression of c fos and c jun genes and their protein production in the calvarial cells . ^^^ In addition , a mixture of antisense oligonucleotides against c fos and c jun significantly inhibited not only the fimbria induced expression of the IL 1 beta gene but also the fimbria induced bone resorption . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we show that HSP 70 suppresses transcription of c fos , an early response gene that is a key component of the ubiquitous AP 1 transcription factor complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of neonatal diethylstilbestrol exposure on c fos and c jun protooncogene expression in the mouse uterus . ^^^ Quantitative and cell type specific expression of c fos and c jun genes after 17beta estradiol ( E 2 ) stimulation , was investigated in the uteri of neonatally diethylstilbestrol ( DES ) exposed and ovariectomized adult mice ( neoDES mice ) , employing Northern blot analysis , immunohistochemistry and in situ hybridization . ^^^ The permanent changes in the expression of estrogen regulated protooncogenes , c fos and c jun genes , by neonatal DES exposure may be responsible for the wide range of abnormalities in the genital tract of mature animals . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha and interleukin 10 release into the perfusate and bile were measured by ELISA , and expression of these cytokines and that of c fos , c jun , and c myc were studied by reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Topical application of curcumin was reported to inhibit TPA induced c fos , c jun and c myc gene expression in mouse skin . ^^^ CONCLUSIONS : Whereas earlier work demonstrated that topical application of curcumin to mouse skin inhibited TPA induced expression of c fos , c jun and c myc oncogenes , our results are the first to show that orally consumed curcumin significantly inhibited DMBA and TPA induced ras and fos gene expression in mouse skin . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This association is suggested by transcriptional activation of the immediate early response genes , c fos and c jun , within 15 min after exposure to cadmium and by the enhancement of AP 1 DNA binding activity , involving a c Jun protein complex , which is maximally induced ( approximately 4 fold ) by 2 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Intense signals for immediate early genes ( IEG ) / transcriptional factors such as c fos , c jun , and nerve growth factor induced gene A ( NGFI A ) mRNAs were observed in the superficial mucosa and in the blood vessels from 15 min to 6 hr after administration , peaking at 15 30 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hirudin , curcumin , and c fos antisense oligonucleotides could block thrombin induced expression of MMP 9 mRNA as well as AP 1 binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
GILZ also potently inhibited AP 1 driven and IL 2 promoter driven reporter constructs , and recombinant GILZ specifically interacted with c Fos and c Jun in vitro and inhibited the binding of active AP 1 to its target DNA . ^^^ Whereas homodimerization of GILZ required the presence of its leucine zipper , the interaction with c Fos and c Jun occurred through the N terminal 60 amino acid region of GILZ . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , studies with mouse embryo fibroblasts null for Smad 3 show that TGF beta dependent induction of c Jun and c Fos , important in induction of collagen as well as in autoinduction of TGF beta , is mediated by Smad 3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Changes in the induction of the IEGs , c fos and c jun , were compared between control and OJ groups in relation to survival before and after partial hepatectomy . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , the expression of some protooncogenes such as c myc , c fos and c jun was examined , showing that salvicine produced a reduction in the transcription rate of c myc in a dose dependent manner and a marked induction of c fos and c jun expression was observed . ^^^ It appears possible that DNA damage within such genomic regions is an early event , which could lead to growth inhibition mediated by alterations of the expression of selected proliferation regulatory genes , such as c myc , c fos and c jun , and ultimately cell death . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Metabolic changes were compared with responses of the genes c fos , c jun , heat shock protein gene ( hsp ) 72 , p 53 activated gene ( pag ) 608 and caspase 3 , which were investigated by in situ hybridization histochemistry and immunocytochemistry , and correlated with the degree of DNA fragmentation , as assessed by the terminal TdT mediated dUTP biotin nick end labeling method . ^^^ C fos and c jun responses completely disappeared within 24 h of reperfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , c fos expression did not require infectious virus particles , as it occurred even with UV inactivated 10 and was equally induced by the different multiplicities of infection , i . e . 1 . 0 , 5 . 0 , and 25 . 0 . c fos expression was preceded by 10 induced DNA binding activity and was mediated via the cis acting elements serum response element ( SRE ) , activating protein 1 ( AP 1 ) , and cAMP response element ( CRE ) . 10 activated the protein kinases p42MAPK / ERK2 and p44MAPK / ERK1 and the transcription factor ATF 1 in a time dependent manner with kinetics that paralleled those of 10 stimulated DNA protein complex formation . ^^^ This assumption was based on the findings that : 1 ) c fos transcript was down regulated ; 2 ) the SRE , AP 1 , and CRE binding activities were significantly reduced ; and 3 ) the activation of p42MAPK / ERK2 , p44MAPK / ERK1 , and ATF 1 were drastically affected when the viral infections were carried out in the presence of specific protein kinase inhibitor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of egr 1 ( krox 24 ) , egr 2 ( krox 20 ) , egr 3 , c jun , junB , c fos , fosB , fra 1 , fra 2 , and CREB genes was analyzed by reverse transcription polymerase chain reaction ( RT PCR ) in Schwann cells isolated from neonatal rat sciatic nerves and in the cell lines MSC 80 ( mouse Schwann cells ) , NIH 3T3 ( mouse fibroblasts ) , and CHO ( Chinese hamster ovary cells ) . ^^^ T 3 triggered a rapid ( 15 30 min ) , transient ( 1 2 h ) and strong ( 6 to 15 fold ) stimulation of Egr 1 , Egr 2 , Egr 3 , Jun B , c Fos , and Fos B mRNA expression in Schwann cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The composition of AP 1 heterodimers revealed c Jun , Jun D , and c Fos as the major subunits upon PMA + / ascorbate stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In HTs but not NTs , kinase activation was followed by overexpression of c fos and enhanced AP 1 DNA binding activity . ^^^ Our findings suggest that augmented Ang 2 stimulated VSMC growth is mediated via hyperactivation of c Src regulated ERK1 / 2 dependent pathways , leading to overexpression of c fos mRNA and enhanced AP 1 DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is suggested that both genistein and daidzein have an inhibitory effect on estrogen related endometrial carcinogenesis in mice , possibly by suppressing expression of estrogen induced estrogen related genes c fos and c jun , and internal cytokines IL 1alpha and TNF alpha through a cytokine and estrogen receptor mediated pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In gel kinase assays were used to assess their kinase activity towards the immediate early gene products c Jun and c Fos [ constituents of the activator protein 1 ( AP 1 ) transcription factor ] . ^^^ RESULTS : Selective members of the MAPK family were rapidly induced by stretching , as manifested by their ability to enhance phosphorylation of their cognate substrates c Jun and , to a lesser extent , c Fos in the in gel kinase assay . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
VP 16 ERalpha and c Jun , which both interact with GRIP 1 , had synergistic effect on GAL 4 GRIP1 induced transcription in the presence of estradiol , and this synergistic effect was not observed with the ERalpha mutant VP 16 ER241G or when c Fos , which bound GRIP 1 but not ERalpha , was used instead of c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PURPOSE : We investigated the expression of the neural plasticity related genes c fos , zif 268 , c jun , brain derived neurotrophic factor and tissue plasminogen activator in the pontine tegmental area in rats with overactive bladder induced by cerebral infarction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the overexpression of certain growth factors and / or their receptors , such as vascular endothelial growth factor ( VEGF ) , epidermal growth factor receptor ( EGFR ) and HER 2 / neu , as well as various oncogenes like c fos and c jun , is associated with unfavorable prognosis and contributes to progressive growth of ovarian carcinomas , their mRNA levels were analyzed by RT PCR . ^^^ Treatment with AN 152 significantly ( P < 0 . 05 ) reduced the expression of EGFR , VEGF , c fos and c jun , to 49 % , 48 % , 55 % and 58 % respectively , compared to controls . ^^^ Conversely , DOX decreased non significantly the expression levels for EGFR by 32 % , VEGF 35 % , both c fos and c jun approximately 20 % and HER 2 / neu by only 15 % . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We isolated the wee 1 gene promoter and found that it contains one AP 1 binding motif and is directly activated by the immediate early gene product c Fos at cellular G ( 1 ) / S phase . ^^^ Thus , an immediate early gene product , c Fos / AP 1 , directly transactivates the wee 1 kinase gene at G ( 1 ) / S . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Addition of nickel to BEAS 2B human airway epithelial cells stimulated intracellular oxidation , induced c Jun and c Fos mRNA levels , increased phospho and total c Jun protein levels , and elevated PAI 1 mRNA levels over a 24 h time course . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cells differed in their susceptibility towards inhibition by genistein of phorbol ester induced proto oncogene c fos levels , transcription factor activator protein 1 ( AP 1 ) activity and extracellular signal regulated kinase ( ERK ) activity . ^^^ The results suggest that induction of apoptosis , G 2 cell cycle arrest and inhibition of c fos expression , AP 1 transactivation and ERK phosphorylation may contribute to the growth inhibitory effect of genistein in some breast cell types , but none of these effects of genistein constitutes a generic mode of growth arresting action . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transient increase of c fos expression was detected after CT treatment , whereas expression of c jun RNA was down regulated after CT treatment . ^^^ These results suggest that CT may regulate early response genes , c fos and c jun , via a MAP kinase cascade . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis revealed binding of c Jun and c Fos to this AP 1 element . ^^^ Region and developmental stage specific expression of ASBT in the rat intestine correlated with the presence of one of these DNA protein complexes and both c Fos and c Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is now apparent that the constitutive elevation in cAMP level induced by the Gsalpha mutations leads to alterations in the expression of several target genes whose promoters contain cAMP responsive elements , such as c fos , c jun , Il 6 and Il 11 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This process is dependent on the induction of the transcription factor AP 1 , a dimeric complex composed of c Fos and c Jun / JunD phosphoproteins . ^^^ Here we show that N terminal phosphorylation of c Jun , the other main partner of c Fos in induced AP 1 complexes is not required for programmed cell death during retinal development in vivo and is also dispensable for photoreceptor apoptosis induced by the exogenous stimuli `` excessive light ' ' and N nitroso N methylurea ( MNU ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using in situ hybridisation with oligonucleotide probes , an expression of immediate early genes c fos , jun B , c jun , and NGFIA in the rat brain was studied following intrastriatal microinjection of corticotropin releasing hormone ( CRH ) . ^^^ The hormone induced expression of c fos , jun B , and NGFIA mRNAs in the neostriatum as well as in its target brain areas , including nucleus accumbens and different cortical areas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos , c jun and HSP 70 mRNA in rat brain following high acceleration stress . ^^^ In the present study expression of IEGs c fos , c jun and stress response gene HSP 70 were measured in the brains of rats subjected to six 30 s exposures of +22 . 5Gz in a small animal centrifuge . ^^^ Expression of c fos and c jun was significantly stimulated at 0 . 5 , 15 , 30 and 60 min post centrifugation . ^^^ It is concluded that the transient expression of c fos , c jun and HSP 70 mRNA is stimulated by repeated ischemic / reperfusion episodes induced by high acceleration stress . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Many investigators have reported that three oncogenes of c fos , c jun and c myc , so called `` Early Response Genes ' ' , were induced at transcriptional level by a diverse set of stresses such as heat , UV and ionizing radiation , and that the accumulation of the product of a tumor suppressor gene , p 53 was induced at post translational level by the same stresses . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AIMS : To investigate the expression of c fos , a constituent of the transcription factor activator protein 1 , in human ASM cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The action of these factors realization is due to immediately and thought growth factor system ( IGF 1 , IGF 2 , EGF , bFGF ) , working as paracrine amplificators of morphogenetic signals and activators of transcriptional factors c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro , c Jun / c Fos , JunB / c Fos , and JunD / c Fos all interact with the Hex homeodomain more strongly than the respective Jun proteins ( or c Fos ) alone , suggesting that heterodimerization exposes reactive regions in the N termini of the Jun proteins . ^^^ In transfected cells , Hex expression inhibits Jun or Jun / c Fos dependent transcription of a reporter gene ; the presence of Hex binding sites in the promoter enhances the inhibitory effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos and c jun are immediate early genes ( IEGs ) that are rapidly expressed after a variety of stimuli . ^^^ Levels of c fos and c jun mRNA and proteins were modest and evenly distributed among enterocytes lining the villi of unperfused intestines . ^^^ Luminal perfusion induces transient but dramatic increases in c fos and c jun expression in villus enterocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The observed increases in expression of c jun , c myc , and c fos related antigen 1 are consistent with increased Wnt pathway activity in PBC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential effects of forskolin and phobol 12 myristate 13 acetate on the c fos and c jun mRNA expression in rat C 6 glioma cells . ^^^ The effects of forskolin ( FSK ) and phobol 12 myristate 13 acetate ( PMA ) on c fos and c jun mRNA expressions in rat C 6 glioma cells were studied . ^^^ When C 6 glioma cells were incubated with PMA and FSK , the PMA induced c jun mRNA level was inhibited by FSK , whereas FSK did not affect the PMA induced c fos mRNA level . ^^^ In addition , DEX appears to have a selective inhibitory action against c fos , but not c jun , mRNA expression that is regulated by PKA and PKC . ^^^ On going protein synthesis inhibition is required for the superinduction of the c fos expression that is induced by PMA , or FSK and the PMA induced c jun mRNA level . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The functional groups and the differentially expressed genes are as follows : The cancer related genes ( nine genes ) were the ets related transcription factor activated by ras , colony stimulating factor , A myb , sky , cot 1 , c fos , c jun , c myc , and R ras proto oncogenes . ^^^ Using c fos and c jun , two of the differentially expressed genes , as model genes , we have found that in the nontransformed BALB / c 3T3 cells , the beryllium induced transcriptional activation of these genes was dependent on pathways of protein kinase C and mitogen activated protein kinase and independent of reactive oxygen species . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^ RESULTS : Of the seven AP 1 factors , three ( c fos , fra 2 , and junB ) clearly showed higher expression levels in tumors when compared to matched normal endometrial samples . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , we find that T kininogen expressing cell lines are still capable of responding to growth factors present in the serum , both by activating the ERK pathway and by expressing early genes , such as c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Early inductions of c myc and c fos proteins , increased activity of MAPK , and activation of AP 1 were observed by pressure loading . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , by immunohistochemistry , we performed staining for the NF kappaB subunits ( p 50 and p 65 ) and AP 1 subunits ( c fos , c jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have also tested a panel of c Jun and c Fos mutants for their activities on the N to C interaction , and the data demonstrate that the activities of these mutants parallel their activities on hAR transactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Such constitutive ERK and JNK activation as a consequence of continued HBx expression also led to sustained stimulation of further downstream events , such as increased levels of c Jun and c Fos proteins along with the persistent induction of activator protein 1 binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We analysed Epo and GM CSF induced ERK1 / 2 activation , c Fos expression , STAT 5 and AP 1 DNA binding activities in mononuclear cells of umbilical cord blood ( UCBMNC ) , normal marrow ( NBMMNC ) or marrow with MDS , AML with prior MDS and de novo AML . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined calpain content and activity , regulation of immediate early genes ( IEGs ) such as c jun and c fos , reactive astrogliosis as the expression of glial fibrillary acidic protein ( GFAP ) , and apoptosis related features such as caspase 3 mRNA expression and internucleosomal DNA fragmentation in 1 cm long spinal cord segments ( S 1 , distant rostral ; S 2 , adjacent rostral ; S 3 , lesion or injury ; S 4 , adjacent caudal ; and S 5 , distant caudal ) following SCI in rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression and purification of recombinant human c Fos / c Jun that is highly active in DNA binding and transcriptional activation in vitro . c Fos and c Jun are members of the AP 1 family of transcriptional activators that regulate the expression of genes during cell proliferation . ^^^ To facilitate in vitro studies of mechanisms of transcriptional activation by c Jun and c Fos we developed a method for obtaining recombinant c Fos / c Jun that is highly active in DNA binding and transcriptional activation in vitro . ^^^ Full length human c Fos and c Jun were expressed in Escherichia coli . ^^^ Both over expressed c Fos and c Jun were recovered from inclusion bodies . ^^^ A c Fos / c Jun complex was generated by co renaturation and purified via a His tag on the full length human c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The GM CSF promoted cell survival and proliferation correlated with MEK 1 dependent ERK1 / 2 , Elk 1 and CREB phosphorylation and Egr 1 , c Fos expression as well as with increased STAT 5 , AP 1 , c Myb and NF kappaB DNA binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Role of interfacial hydrophobic residues in the stabilization of the leucine zipper structures of the transcription factors c Fos and c Jun . ^^^ In particular , the effect of temperature change over the range of T = 278 338 K on the thermodynamics of interaction of several leucine zipper coiled coil polypeptides related to the transcription factors , c Fos and c Jun , following binding to immobilized n octyl ligands has been determined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , to investigate the functional consequences of c fos and junB induction , MOR mediated formation of the functional transcription factor complex AP 1 was examined by reporter assay and electrophoretic mobility shift assay . ^^^ Electrophoretic mobility shift assay revealed that AP 1 binding activity in the nuclear extract was elevated by MOR activation and further showed that products of c fos and junB genes are involved in formation of AP 1 complex . ^^^ CONCLUSIONS : Mu opioid receptor activation induces c fos and junB expression and elevates AP 1 mediated transcriptional activities via the mitogen activated protein kinase cascade . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , using supershift analysis , we documented the involvement of c Fos and , to a lesser extent , c Jun in leptin induced activating protein 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Physical interaction of the activator protein 1 factors c Fos and c Jun with Cbfa 1 for collagenase 3 promoter activation . ^^^ Previously , we determined that the activator protein 1 ( AP 1 ) binding site and the runt domain ( RD ) binding site and their binding proteins , c Fos . c Jun and Cbfa , regulate the collagenase 3 promoter in parathyroid hormone treated and differentiating osteoblasts . ^^^ Here we show that Cbfa 1 and c Fos . c Jun appear to cooperatively bind the RD and AP 1 binding sites and form ternary structures in vitro . ^^^ Thus , we provide direct evidence that Cbfa 1 and c Fos . c Jun physically interact and cooperatively bind the AP 1 and RD binding sites in the collagenase 3 promoter . ^^^ Both in vitro and in vivo co immunoprecipitation and yeast two hybrid studies further demonstrate interaction between Cbfa 1 with c Fos and c Jun in the absence of phosphorylation and without binding to DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Following kainate ( KA ) induced epilepsy , rat hippocampal neurons strongly express immediate early gene ( IEG ) products , i . e . , c FOS and c JUN , and neural stress protein , HSP 72 . ^^^ Prolonged expression of c JUN and c FOS 48 hr after cerebral ischemia has been underwent delayed neuronal death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , constitutive binding of activator protein 1 ( AP 1 ) was detected , and changes in c fos expression could modulate promoter activity . ^^^ We propose that activated STATs stimulate c fos expression , and changes in expression of the AP 1 components regulate MMP 1 expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The critical role of AP 1 in the PR 2 position was confirmed by supershift of the PR 2 complex with c Fos antibody and markedly decreased activity of the construct with a mutated AP 1 site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ATRA did not interfere with other early mitogenic signals either , such as the phosphorylation of FGF 1 receptor or the induction of immediate early genes c fos , c jun , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gene amplification was investigated in K ras , c myc , c fos , c jun , c sis , erb B 2 and p 53 using differential PCR while random amplified polymorphic DNA fingerprinting was employed to detect genomic instability . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c Fos , Fos B , Jun B , and Zif 268 transcription factor proteins in rat barrel cortex following apomorphine evoked whisking behavior . ^^^ Apomorphine evoked expression of transcription factor proteins : c Fos , Fos B , Jun B , and Zif 268 ( also named Krox 24 , NGFI A , Egr 1 ) , was investigated in rat somatosensory ( barrel ) cortex . ^^^ In contrast , apomorphine ( 5 . 0 mg / kg ) evoked marked c Fos elevation , less pronounced changes in Jun B and Zif 268 and no change in Fos B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Basic calcium phosphate crystals induce matrix metalloproteinase 1 through the Ras / mitogen activated protein kinase / c Fos / AP 1 / metalloproteinase 1 pathway . ^^^ Taken together , these data indicate that multiple elements , including at least AP 1 and PEA 3 , are involved in the induction of hMMP 1 gene expression by BCP crystals and that the induction follows the Ras / MAPK / c Fos / AP 1 / MMP1 signaling pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Anergy is accompanied by a reduction in AP 1 binding to the IL 2 promoter , with selective reduction in binding of c Fos , JunB , and JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Wortmannin stimulation of RAW 264 . 7 macrophages is followed by sustained expression of the mRNA of c fos and a transient expression of the mRNA of c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Sequential up regulation of the c fos , c jun and bax genes in the cortex , striatum and cerebellum induced by a single injection of a low dose of 1 methyl 4 phenyl 1 , 2 , 3 , 6 tetrahydropyridine ( MPTP ) in C57BL / 6 mice . ^^^ We investigated whether single injection of 1 methyl 4 phenyl 1 , 2 , 3 , 6 tetrahydropyridine ( MPTP ) ( 20 mg / kg ) will alter the expression of pro apoptotic genes , namely , the c fos , c jun , and bax , in the striatum , cortex , and cerebellum of adult male C57BL / 6 mice using reverse transcription polymerase chain reaction assay . ^^^ A rapid but transient up regulation of c fos and c jun genes occurred an hour after MPTP injection , and a delayed but persistent up regulation of bax gene expression occurred 3 day after injection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of the AP 1 protein c Jun , but not c Fos , strongly enhanced SKF induced ERalpha target gene expression but only when the TRE was present . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C Jun and c Fos belong to the family of immediate early genes . ^^^ The expression of c Jun and c Fos in sensory ganglia of guinea pig , rat and murine sensory ganglia was examined under normal , unstimulated conditions by quantitative double immunohistochemistry . 4 . 6 + / 2 . 8 % of neuron specific protein gene product 9 . 5 positive cells in nodose ganglia , 51 . 6 + / 2 . 1 % in jugular ganglia , 46 . 4 + / 3 . 0 % in trigeminal ganglia and 42 . 5 + / 1 . 3 % of cervical dorsal root ganglia neurons were positive for c Jun in the guinea pig ( less than 1 % for c Fos ) . ^^^ In rat and mouse , less than 1 % of the sensory neurons exhibited c Jun and c Fos immunoreactivity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In hippocampus of young , aged unimpaired and aged impaired rats , AP 1 consists mainly of c Jun , phosphorylated c Jun ( p c Jun ) , JunD , and smaller amounts of c Fos . ^^^ We conclude that the basal expression of c fos and c jun mRNA , overall AP 1 binding activity and AP 1 composition are not influenced by aging or cognitive ability . . ^^^ Levels of c jun and c fos mRNAs were unchanged with aging or spatial learning ability . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , hypoxia increased the transcriptional activity of a 12 O tetradecanoylphorbol 13 acetate response element like motif on the GRP 78 promoter and increased the abundance and DNA binding activity of AP 1 complex composed of c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNA expression of immediate early genes ( IEG ) such as c fos , c jun and NGFI A , cyclooxygenase ( COX ) 2 and heat shock proteins ( HSP ) 70 in the stomach were studied using in situ hybridization histochemistry . ^^^ In the restraint stress model , IEG ( c fos and NGFI A ) mRNAs were induced in the pit and isthmus of the mucosa , while in the ethanol exposure model , IEG ( c fos , c jun and NGFI A ) and HSP 70 mRNAs were upregulated in the damaged epithelium , especially surrounding the deep erosions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to determine the identities of individual B ZIP proteins in various AP 1 complexes we tested the effect of dominant negative mutants to the B ZIP proteins c Fos , ATF 2 , ATF 4 and CCAAT enhancer binding protein ( C / EBP ) on the activities of the collagenase and c Jun promoters . ^^^ Transcription of a collagenase promoter / reporter gene was induced in HepG 2 hepatoma cells by expression of c Fos and c Jun , administration of PMA ( `` TPA ' ' ) or by expression of a truncated form of MEK ( mitogen activated / extracellular signal regulated kinase kinase ) kinase 1 , MEKK1Delta . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transient induction of metallothionein isoform 3 ( MT 3 ) , c fos , c jun and c myc in human proximal tubule cells exposed to cadmium . ^^^ Expression of MT 3 mRNA and protein was determined in cultured HPT cells and HK 2 cells using reverse transcription polymerase chain reaction ( RT PCR ) and immuno blotting , and expression of c fos , c jun and c myc mRNA by RT PCR . ^^^ It was also demonstrated that the pattern of expression of MT 3 mRNA was similar to that of the early response genes , c fos , c jun and c myc . ^^^ It was shown that the HK 2 cells did not express MT 3 when exposed to Cd ( +2 ) , but had similar expression of the c fos , c jun and c myc genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blotting analysis of c Fos and c Jun suggested that up regulation of c fos and c jun gene expression does not directly contribute to the induction of AP 1 activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A weak C fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c Fos , FosB , Krox 20 or Krox 24 ; but it did reduce the basal expressions of c Jun and JunD in both the medial and lateral areas . ^^^ With repeated stimulation , i . e . when the noxious stimulus was applied to the contralateral hindpaw 6 h after the sciatic stimulation , there was again no induction of c Fos , FosB or Krox 20 in the medial thalamus ; but there was an increase in c Jun and Krox 24 , and a decrease in JunD levels . ^^^ In the lateral thalamus the repeated stimulation again failed to induce c Fos , but the expressions of FosB , c Jun and Krox 24 were increased , and that of JunD was again reduced . ^^^ With coincident stimulation , i . e . when a stimulus was applied to each hindpaw simultaneously , c Fos and Krox 24 remained absent ; but there was a marked induction of FosB and Krox 20 , a strong repression of c Jun , and no effect or a reduction of the basal levels of JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated by RT PCR whether PROG activated expression of transcription factors : Egr 1 ( Krox 24 ) Egr 2 ( Krox 20 ) , Egr 3 , c jun , jun B , jun D , c Fos , Fos B , Fra 1 , Fra 2 , CREB , ATF 4 , SCIP and Sox 10 in cultured Schwann cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein composition of the AP 1 transcription factor complex activated by bryo 1 was analyzed using supershift analysis with specific antibodies against c Fos , Fos B , c Jun , Jun B , and Jun D proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Wnt mediated repression of c Fos , FosB , and JunB expression was consistent with a decrease in their binding to an AP 1 promoter element and decreased target gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MMP 13 mRNA up regulation was preceded by up regulation of c jun and c fos mRNA . ^^^ The mRNA levels of c jun and c fos in response to MIF were also inhibited by PD 98059 . ^^^ Osteoblasts obtained from calvariae of newborn JunAA mice , defective in phosphorylation of c Jun , or newborn c Fos knockout ( Fos / ) mice , showed much less induction of MMP 13 with the addition of MIF than osteoblasts obtained from wild type or littermate control mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
With the aim to identify the oncoprotein partners implicated in the c Jun myogenic influence , we carried out stable transfection experiments of c Jun and / or ATF 2 , Fra 2 , c Fos overexpression in avian myoblasts . ^^^ In search for specific partners involved in this dual influence , we found that a reduction in the amounts of c Fos and Fra 2 and an increase in c Jun proteins occurred at cell confluence , a situation likely to favor cooperation between c Jun and ATF 2 during terminal differentiation . ^^^ Whereas c Fos and Fra 2 cooperated with c Jun to abrogate myoblast withdrawal from the cell cycle and terminal differentiation , ATF 2 co expression potentiated the positive myogenic c Jun influence . ^^^ In addition , myogenin expression was a positive target of this cooperation and this regulation occurred through a stimulation of myogenin promoter activity : ( 1 ) whereas c Fos or Fra 2 co expression abrogated c Jun stimulatory activity on this promoter , ATF 2 co expression potentiated this influence ; ( 2 ) using a dominant negative ATF 2 mutant , we established that c Jun transcriptional activity required functionality of endogenous ATF 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to detect the putative relation of Hsp 27 with AP 1 activation in human astrocytomas we examined eighty astrocytic tumors with different grades of malignancy for c Jun , c Fos , and Hsp 27 expression . ^^^ METHODS : Six pilocytic astrocytomas ( WHO grade 1 ) , 15 diffuse fibrillary astrocytomas ( WHO grade 2 ) , 19 anaplastic astrocytomas ( WHO grade 3 ) , and 40 glioblastomas multiforme ( WHO grade 4 ) , were studied by immunohistochemistry using monoclonal and polyclonal antibodies directed against human Hsp 27 , c Fos , and active ( phosphorylated ) forms of c Jun ( p c Jun ) . ^^^ RESULTS : Overexpression of p c Jun , c Fos and p JNK was observed in the majority of glioblastomas ( grade 4 ) whereas only minimal expression was noted in diffuse fibrillary astrocytomas ( grade 2 ) . ^^^ Hsp 27 expression was observed only in the tumor specimens where c Jun and c Fos were co expressed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of selenium on hepatocellular protooncogene c myc , c fos and c jun expression induced by cadmium in rats ] . ^^^ OBJECTIVES : This study was conducted to explore effects of selenium on hepatocellular protooncogene c myc , c fos and c jun expression induced by cadmium in rats . ^^^ Protooncogene c myc , c fos and c jun expression in rat liver cells was measured with Northern Dot Hybridization . ^^^ RESULTS : The results showed that cadmium chloride at doses of 5 , 10 or 20 mumol / kg , significantly induced proto oncogene c myc , c fos and c jun expression , and when sodium selenite at the dose of 5 mumol / kg was given at the time , the effect of cadmium chloride on hepatocellular protooncogene c myc , c fos and c jun expression was inhibited . ^^^ CONCLUSION : Selenium at certain doses could inhibit hepatocellular protooncogene c myc , c fos and c jun expression induced by cadmium in rats . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun protooncogenes expression by formaldehyde releasing and epoxy resin based root canal sealers in human osteoblastic cells . ^^^ It has been shown that c fos and c jun are induced rapidly by a variety of chemical and physical stimuli . ^^^ Numerous works have extensively investigated the induction mechanisms of c fos and c jun protooncogenes by these agents ; however , little is known about the induction of cellular signaling events and specific gene expression after cell exposure to root canal sealers . ^^^ Therefore , we used osteoblastic cell line U 2 OS to examine the effect of zinc oxide eugenol based ( N 2 and Endomethasome ) , epoxy resin based ( AH Plus ) , and calcium hydroxide based ( Sealapex ) root canal sealers on the expression of c fos and c jun protooncogenes to understand in more detail the molecular mechanisms of root canal sealer induced genotoxicity . ^^^ In addition , N 2 , Endomethasome , and AH Plus rapidly induced c jun and c fos mRNA levels in cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 consists of several proteins , including those encoded by the proto oncogenes c jun and c fos . ^^^ Differential expression of c jun and c fos mRNAs in squamous cell carcinoma of the head and neck : associations with uPA , gelatinase B , and matrilysin mRNAs . ^^^ AP 1 consists of several proteins , including those encoded by the proto oncogenes c jun and c fos . ^^^ The aim of this study was to : first , evaluate the expression levels of matrix metalloproteases ( matrilysin and gelatinase B ) and uPA mRNAs ; second , examine whether these genes might be associated with c jun and c fos expression ; third , examine the relationship between the expression of these genes and HNSCC clinico pathological features . ^^^ METHODS : We have analyzed 38 HNSCC primary tumors and matched mucosa tissues for uPA , gelatinase B , matrilysin , c fos , and c jun by Northern blot analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : Electrophoretic mobility shift assay ( EMSA ) was employed to assess AP 1 DNA binding activity , and Western blot hybridization was used for quantification of c fos and c jun , two subunits of AP 1 dimers . ^^^ Further study demonstrated that thrombin promoted AP 1 DNA binding activity but exerted little effect on c fos or c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of oncoproteins c fos and c jun in hypertrophic scars and chronic dermal ulcers and their regulation of basic fibroblast growth factor . ^^^ OBJECTIVE : To explore the characteristics of oncoprotein expression of c fos and c jun in hypertrophic scars and chronic dermal ulcers and their regulation of basic fibroblast growth factor ( bFGF ) . ^^^ The ABC immunohistochemical method was used to characterize the gene product expression of c fos , c jun and bFGF in the above tissues . ^^^ RESULTS : In normal skin , both c fos and c jun protein expression and bFGF protein expression were observed . ^^^ The different expressions of c fos and c jun gene products play an important role in regulate bFGF action , thus affecting wound healing . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The level of AP 1 binding correlated with the activity of its response element but not with the levels of its leucine zipper containing subunits , c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The two known serum inducible immediate early genes c fos and c jun showed similar expression kinetics , with c jun mRNA levels peaking at 15 min and c fos at 20 min . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of tsaoko anemarrhenae decoction on intracerebral c fos , c jun mRNA expression in interrupting pentylentetrazol kindled epileptic rat model ] . ^^^ The effects of TAD on the c fos , c jun gene expression in the rats ' brain were observed by in situ hybridisation . ^^^ RESULTS : The c fos , c jun gene expression was obviously increased , TAD could effectively block the gene expression of c fos , c jun , showing better antiepileptic effect . ^^^ CONCLUSION : The mechanism of TAD anti epileptic effect might be correlated to the decrease of c fos , c jun gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the immediate early phase after the imposition of ascending aortic banding , the mRNA expression of proto oncogenes ( c fos , c jun and c myc ) was diminished in aged rat hearts compared with young adult hearts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c jun , c fos and MDM 2 mRNA in cultured kerotinocytes through transfecting HPV 16 ] . ^^^ OBJECTIVE : To study the expression of c jun , c fos and MDM 2 mRNA in cultured kerotinocytes through transfecting HPV 16 . ^^^ Reverse transcriptase polymerase chain reaction ( RT PCR ) was used to detect c jun , c fos and MDM 2 mRNA in keratinocytes of normal and transfected keratinocytes . ^^^ In the transfected keratinocytes , the exprssions of c jun , c fos and MDM 2 mRNA were detected and the products were 196 bp , 332 bp and 548 bp fragments , respectively . ^^^ CONCLUSION : HPV leads to cell proliferation by expressing c jun , c fos and MDM2 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Another signaling cascade by which GSA activates VSMCs is the ERK > c Fos > AP 1 pathway , which may lead to stimulation of cell proliferation and migration . ^^^ GSA increased expression of early response genes , c fos and c jun , and inflammatory genes , monocyte chemoattractant peptide ( MCP 1 ) , and interleukin ( IL ) 6 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated whether adrenoceptors , which modulate other central actions of angiotensin 2 like the vasopressin release , also play a role in the AT 1 receptor mediated expression of the transcription factors ( TF ) c Fos , c Jun and Krox 24 in the rat brain . ^^^ Ang 2 , injected intracerebroventricularly , induced the expression of c Fos , c Jun and Krox 24 in the hypothalamic paraventricular ( PVN ) and supraoptic ( SON ) nuclei . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , increased BNP AP 1 binding activity and the presence of c fos were demonstrated in wall stretch stimulated ventricles compared with unloaded ventricles . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of phosphorylation of MAPK and Stat 3 and expression of c fos and c jun proteins on hepatocarcinogenesis and their clinical significance . ^^^ AIM : To study the effect of phosphorylation of MAPK and Stat 3 and the expression of c fos and c jun proteins on hepatocellular carcinogenesis and their clinical significance . ^^^ METHODS : SP immunohistochemistry was used to detect the expression of p42 / 44 ( MAPK ) , p Stat 3 , c fos and c jun proteins in 55 hepatocellular carcinomas ( HCC ) and their surrounding liver tissues . ^^^ RESULTS : The positive rates and expression levels of p42 / 44 ( MAPK ) , p Stat 3 , c fos and c jun proteins in HCCs were significantly higher than those in pericarcinomatous liver tissues ( PCLT ) . ^^^ A positive correlation was observed between the expression of p42 / 44 ( MAPK ) and c fos proteins , and between p Stat 3 and c jun but there was no significant correlation between p42 / 44 ( MAPK ) and p Stat 3 in HCCs and their surrounding liver tissues . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Forty six globes were processed for in situ hybridization with oligonucleotide probes for c fos , fosB , c jun , junB and junD mRNAs , and 60 globes were immunohistochemically analysed using anti c Fos and anti c Jun antibodies . ^^^ Normal lens epithelial cells expressed mRNA signals for junD , but not for c fos , fosB , c jun , and junB . mRNAs for c fos , fosB , c jun , and junB were detected in the whole lens epithelium from the vicinity to the wound to the equator from 30 min to 8 hr post injury with their peaks after 30 min to 1 hr , but were no longer detected at 10 hr or later . ^^^ Expression of c fos mRNA in the equatorial lens cells was more marked than that of c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CONCLUSIONS : Cardiopulmonary bypass with myocardial ischemia rapidly induces the immediate early genes TIS7 / PC4 ( discovered by subtraction hybridization ) , and c fos and c jun ( precursors to the transcriptional regulator AP 1 ) . ^^^ This prompted characterization of the related immediate early genes c fos and c jun , by Northern analysis and in situ hybridization in human and lamb myocardium subjected to cardiopulmonary bypass with myocardial ischemia . ^^^ RESULTS : In ischemic reperfused myocardium at endcardiopulmonary bypass , c fos , c jun , and TIS7 / PC4 were induced , whereas iNOS transcripts were undetectable . ^^^ Expression patterns of c fos and c jun by in situ hybridization were markedly different ; myocardial c fos expression was diffuse and homogeneous , whereas c jun expression was patchy with areas of intense focal localization . ^^^ Immediate early genes presumably contribute to activation of inflammatory mediators after cardiopulmonary bypass and differences in their tissue expression patterns , as observed for c fos and c jun , presumably modulate their effect upon downstream gene activation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hypertrophy was accompanied by the induction of the immediate early response genes , c fos and c jun , and reexpression of atrial natriuretic peptide ( ANP ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of immediate early response genes such as c fos , c jun , and c myc in response to 1 500 microT resultant ( r ) 60 Hz elliptically polarized ( EP ) magnetic fields ( MFs ) , typical of environmental MFs polarization under overhead power lines , was analyzed in both at transcriptional and translational levels using human glioblastoma ( T98G ) cells . ^^^ Pseudo synchronized T98G cells at G 1 phase were exposed to EP MFs ( 1 , 20 , 100 , and 500 microTr ) for up to 3 h , but produced no statistical difference ( P > 0 . 05 ) in the levels of expression ratio at both the transcriptional and translational levels at 30 min for c fos and c jun and at 180 min for c myc after serum stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transactivation of the gammaD MARE by c Maf in lens cells was not enhanced by c Fos or c Jun and was not blocked by dominant negative c Fos or c Jun constructs . c Maf can activate the gammaD MARE as a homodimer since activation of the gammaD crystallin promoter in P 19 embryonic carcinoma cells required only c Maf , but none of a number of c Fos and c Jun family members tested . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After the study about the induction of EGF on human A 431 cell line , it was observed that EGF induced c fos and c jun expression decreased in microgravity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The signal transduction pathways associated with these receptors , and the expression of proto oncogenes c fos , c myc and c jun at the mRNA and protein levels , were examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The molecular markers employed include the NMDA receptor subunit type 1 , the cAMP response element binding protein ( CREB ) , the immediate early gene products c Fos , c Jun and Egr 1 , the growth and plasticity associated protein GAP 43 and its mRNA , the calcium binding protein calbindin , the cell adhesion molecule integrin alpha ( 1 ) , the microtubule associated protein MAP 1b , and the neurofilament light chain ( NF L ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c Fos after noise induced temporary threshold shift in the guinea pig cochlea . c Fos is known to be a component of a transcription factor , activator protein 1 , which is induced by oxidative stress . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
REF cells transformed by oncogenes E1A and cHa ras reveal high and constitutive DNA binding activity of AP 1 factor lacking in c Fos protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Time course experiments revealed that mechanical stretch loaded hPDL cells exhibit a very rapid and relatively sustained increase in the abundance of the immediate early gene products , c Fos and c Jun , components of the activator protein 1 ( AP 1 ) transcription factor . ^^^ Effect of protein kinase inhibitors on the stretch elicited c Fos and c Jun up regulation in human PDL osteoblast like cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , DMSO reduced the expression of immediate early genes ( IEG ) expression ( c myc , c jun , c fos , junB , egr 1 ) and inhibited mitogen activated protein kinase ( MEK ) kinase / extracellular signal regulated kinases ( ERKs ) and p 38 phosphorylation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The significance and characteristics of the gene expressions of c fos and c jun in hypertrophic scar and chronic ulcer tissues ] . ^^^ OBJECTIVE : To explore the characteristics and regularity of the expression of c fos and c jun genes in hypertrophic scar and chronic ulcer tissues and their relationship to different tissue restoration . ^^^ RESULTS : The positive expression of c fos and c jun gene was found in epithelial basal cells and some subcutaneous fibroblasts in normal skin . ^^^ But the expression of c jun was weaker than that of c fos in above tissues . ^^^ A strong positive expression of c fos and c jun genes was found mainly in fibroblasts in the hypertrophic scar . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , AP 1 activation was independent of c Fos . ^^^ This was accompanied by an activation of c Jun and ATF 2 , but not Elk 1 and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Taken together , these data suggest that the PG induces phosphorylation of p 38 MAPK but not of SAPK / JNK and that it increases the expression of both c jun and c fos oncoproteins . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Calcitonin gene related peptide induces AP 1 activity by a PKA and c fos dependent mechanism in pre B cells . ^^^ These results suggest that regulatory influences of CGRP on early B cells and in other tissues can involve a cAMP / PKA , c fos / AP 1 dependent pathway for regulation of specific genes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We developed a sensitive ribonuclease ( RNase ) protection assay for the messenger RNA ( mRNA ) levels of immediate early ( IE ) genes ( c jun , c fos and c myc ) , as well as platelet derived growth factor A ( PDGF A ) , platelet derived growth factor beta receptor , transforming growth factor beta 1 , and vascular endothelial growth factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mice of the three Tg lines analyzed exhibit altered levels of expression of several target mRNAs , such as c myc , c jun , c fos , granulocyte macrophage colony stimulating factor , and tumor necrosis factor alpha . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cellular abundance of the oncogene suppressor protein p 53 , serine phosphorylation of p 53 , and abundance of c fos , c jun , and p 21 mRNAs were also increased by RV . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Bombesin antagonists inhibit growth of MDA MB 435 estrogen independent breast cancers and decrease the expression of the ErbB 2 / HER 2 oncoprotein and c jun and c fos oncogenes . ^^^ We also evaluated whether the mRNA expression for the c jun and c fos oncogenes is affected by the therapy . ^^^ Tumor inhibition was associated with a substantial reduction in the expression of mRNA and protein levels of the ErbB / HER receptor family as well as with a decrease in the expression of c jun and c fos oncogenes . ^^^ BN / GRP antagonists RC 3940 2 and RC 3095 could be considered for endocrine therapy of estrogen independent breast cancers that express members of the ErbB / HER receptor family and the c jun and c fos oncogenes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several cytokine and immediate early ( e . g . , c fos and c jun ) mRNAs are upregulated by ciprofloxacin , possibly reflecting a mammalian stress response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An example discussed in this review is the activator protein 1 ( AP 1 ) , the product of the c fos gene and other immediate early genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , the expression of c Jun and c Fos , the major components of transcription factor activator protein ( AP 1 ) , were evaluated to determine possible alterations to these factors in oral squamous cell carcinoma ( OSCC ) . ^^^ Immunolocalization of c Fos and c Jun in human oral mucosa and in oral squamous cell carcinoma . ^^^ BACKGROUND : Studies have addressed the relevance of c Jun and c Fos proteins in cancer development . ^^^ Tissues were submitted for immunohistochemical analysis to detect c Jun and c Fos proteins . ^^^ RESULTS : The results showed that both c Jun and c Fos are expressed in normal oral mucosa and in OSCC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The inductive effects of HER 2 / neu were mediated , in part , by enhanced binding of AP 1 ( c Jun , c Fos , and ATF 2 ) to the cyclic AMP response element ( 59 / 53 ) of the COX 2 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of this gene is often associated with induction of the AP 1 transcription factor , c Fos . ^^^ Consequently , our results suggest that c Fos exerts its influence on the tyrosine hydroxylase gene via multiple mechanisms that are dependent and independent of the proximal promoter AP 1 site . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RT PCR analysis of nerve growth factor mediated changes in AP 1 transcription factors showed rapid increases in c fos and junB mRNA in PC 12 and B5P cells , while increases in c jun were small . ^^^ Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^ In Fos / Jun functional luciferase reporter assays , nerve growth factor stimulated phosphorylation of c Fos in both PC 12 and B5P cells , but phosphorylation of c Jun only in PC 12 , and not in B5P cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blot analysis showed that the levels of c Fos and c Jun protein expression , which increased at 1 h after partial hepatectomy , were also reduced by methotrexate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of heterophilic and homophilic interactions of cadherins using the c Jun / c Fos dimerization domains . ^^^ At 2 mm Ca ( 2+ ) associated rings involving two cis dimers indicate trans contacts in electron micrographs . cis and trans interactions were further analyzed by heterodimerization of the ectodomains of E cadherin ( ECAD ) and P cadherin ( PCAD ) through the leucine zipper domains of c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ileal ornithine decarboxylase mRNA expression was increased with PRED , but there were no steroid associated changes in the expression of the mRNA of the early response genes c myc , c jun , or c fos or of proglucagon , the liver fatty acid binding protein ( FABP ) , the ileal lipid binding protein , tumor necrosis factor alpha , interleukin 2 ( IL 2 ) , IL 6 , or IL 10 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional repression of the rat steroidogenic acute regulatory ( StAR ) protein gene by the AP 1 family member c Fos . ^^^ A search of the rat StAR promoter revealed three putative AP 1 elements at bp positions 85 , 187 and 1561 , which demonstrated specific binding of c Fos by mobility shift assays . ^^^ Mutation of all three AP 1 sites in the p 1862 StAR promoter abolished c Fos repression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Repeated MAP administration induces immediate early gene such as c fos , c jun and arc , and the increase in arc is inhibited by D 1 and NMDA antagonists , suggesting an important role of such genes in inducing reverse tolerance . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hcys also increases the levels of c fos mRNA in Mo and enhanced nuclear protein binding to the AP 1 sequence of the LPL gene promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
VIP antagonist JV 1 53 reduced tumor weight by 67 % ( p < 0 . 01 ) and suppressed the expression of mRNA for c fos and c jun oncogenes by about 34 % ( p < 0 . 05 ) , without affecting serum levels of insulin like growth factor 1 ( IGF 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift and immunoblotting analyses revealed participation of c Fos , Fos B , and Jun B proteins in potentiation by kainate of mitochondrial AP 1 DNA binding in cortex and hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNA values for tumor necrosis factor alpha ( TNF alpha ) , connective tissue growth factor ( CTGF ) , insulin like growth factor 2 ( IGF 2 ) , and decorin were significantly high at specific times after wounding , but mRNA values for the transcription factors ( c fos and c jun ) were significantly decreased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c Fos proteins form heterodimers with Jun family proteins , and the resulting AP 1 complexes regulate transcription by binding to the AP 1 sequence found in many cellular genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factor , activator protein 1 ( AP 1 ) complexes ( c Jun and c Fos heterodimers ) has been shown to interact with transforming growth factor beta signaling in mammalian cells and Drosophila embryo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , electrophoretic mobility shift assay and cotransfection experiments showed that c jun and c fos proteins bound to the AP 1 site and functionally transactivated the icIL 1Ra promoter in mouse carcinoma CH 72 cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , after incubation with leptin , increased nuclear staining of c fos and c jun , the major components of the transcription factor AP 1 , and increased AP 1 DNA binding were observed . ^^^ Transient transfection studies with ET 1 promoter constructs showed that leptin induced promoter activity was abolished in the absence of AP 1 binding sites or by cotransfection with a plasmid overexpressing a mutated jun , which is able to bind c fos but not DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to study the role of immediate early genes ( IEG ) in the neurotoxic mechanism of lead , expression of c fos and c jun genes in different regions of rat brain treated with lead ( 13 and 130 mg / kg ) were observed by using immuno histochemical method . ^^^ The observation and image analysis showed that after rats treated by lead for 2 hours , the c fos and c jun expression in cortex , CA 3 area of hippocampus and cerebellum of rats were higher than those of control rats significantly ( P < 0 . 05 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both de novo transcription and translation contributed to the UVA induced AP 1 DNA binding . c Fos was implicated as a primary component of the AP 1 DNA binding complex . ^^^ A strong correlation existed between UVA induced AP 1 activity and accumulation of c Fos , c Jun and Fra 1 proteins . ^^^ These results demonstrate that UVA irradiation activates AP 1 and that c fos induction may play a critical role in the response of these human keratinocytes to UVA irradiation . . ^^^ UVA irradiation induced protein expression of c Fos , c Jun , Fra 1 and Fra 2 . ^^^ UVA irradiation also induced c fos and c jun mRNA expression and transcriptional activation of the c fos gene promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fra 1 substitutes for c Fos in AP 1 mediated signal transduction in retinal apoptosis . ^^^ Lack of the AP 1 member c Fos protects photoreceptors against light induced apoptosis , a model for retinal degeneration . ^^^ Opposite to wild type mice , Fra 1 , but not c Fos , was detectable in AP 1 complexes of Fos ( Fosl1 / Fosl1 ) mice . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overall , the complex induction pattern of p CREB , along with our earlier observations of the early induction of c fos , c jun and Protein Kinase A ( PKA ) as well as the induction of Calcium2+ / Calmodulin dependent Protein Kinase 2 ( CaM kinase 2 ) at later periods , strongly suggest an activator role of CREB mediated pathways that may lead to the clinical development of delayed neurotoxicity . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , 15d PGJ ( 2 ) increased c Jun and c Fos DNA binding activity in astrocytes , which may result in the activation of other inflammatory pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we demonstrate that immediate early gene ( i . e . c myc , c fos ) expression and AP 1 activity are preserved in AHF rat livers despite absence of hepatocyte proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ODN driven up regulation of cyclin D ( 2 ) , c Myc , c Fos , c Jun and Bcl ( XL ) and down regulation of cyclin kinase inhibitor p 27 ( kip 1 ) were all blocked by inhibitory ODN . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The MEK inhibitor PD 98059 produced near complete ( 97 98 % ) inhibition of ERK phosphorylation , whereas inhibition of c Fos , c Jun , HB EGF , AR , and VEGF mRNA by this compound was incomplete ( 41 65 % ) . ^^^ PD 98059 was significantly more effective than either PD 158780 or BB 2516 as an inhibitor of ERK phosphorylation and of the rapid rise in c Fos and c Jun mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we investigated the effect of PDGF on the expression of c fos and c jun , because c fos and c jun form activator protein 1 complexes that stimulate genes involved in proliferation . ^^^ We determined whether pentoxifylline would alter the expression of c fos and c jun . ^^^ Our results indicate that PDGF induced the expression of both c fos and c jun . ^^^ Pentoxifylline effectively reduced c jun gene expression , which had been up regulated by PDGF , but did not alter c fos gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos and c jun expressions in nitric oxide synthase immunoreactive neurons in the lateral geniculate nucleus of experimental glaucomatous rats . ^^^ The present study was initiated to investigate the expressions of c fos and c jun in nitric oxide synthase immunoreactive neurons and their possible roles in the lateral geniculate nucleus ( LGN ) of glaucomatous rats . ^^^ Animals were killed by cardiac perfusion , and brains containing the LGN were removed and processed for c fos , c jun and neuronal nitric oxide synthase ( nNOS ) immunohistochemistry . ^^^ No c fos or c jun immunoreactivity was observed in the LGN of control rats . ^^^ In the glaucomatous rats , expression of c fos and c jun was induced bilaterally in the ventral LGN ( vLGN ) as early as 2 h postoperation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have also shown that acid stimulated NHE 3 activity depends on activation of Pyk 2 , c Src , MAP kinase , and the immediate early genes c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We observed that withdrawal of IL 7 induced increased expression of jun and fos family member genes including c jun , junB , junD , c fos and fra 2 . ^^^ The stress response contributed to cell death following IL 7 withdrawal as shown by blocking the activity of the stress ( MAP ) kinases or by blocking the production of c Jun and c Fos using antisense oligonucleotides . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immediate responses to KA are hsp 70 mRNA induction and HSP 70 / 72 protein expression , as well as c fos and c jun mRNA , and c Fos and c Jun protein expression in the hippocampus . ^^^ Yet increased c Fos and c Jun expression is not a predictor of cell death or cell survival . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mechanism of this effect appears to involve activation of the AP 1 site by increased c fos protein . . ^^^ Northern and Western analyses indicated that 10 ( 6 ) M dexamethasone markedly increased the abundance of c fos mRNA at 20 min and c fos protein concentration at 60 min in 1 , 25 ( OH ) 2D3 treated UMR 106 cells but only slightly induced the abundance of c jun mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Noticeably , expression of c fos , c jun ( AP 1 ) , HNF 6 , CCAAT / enhancer binding protein beta and delta , tissue specific enhancer 1 , Ah receptor , and albumin D site binding protein was unchanged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of both c fos ( through the transcription factor Elk 1 ) and c jun , both immediate early genes , is important for the stimulation of VSMC proliferation and migration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibodies revealed that the activated AP 1 complex is composed predominantly of c Fos / c Jun heterodimers . ^^^ Treatment of the cells with ADP , C5a and H ( 2 ) O ( 2 ) ( 100 microM ) all increased the phosphorylation of c Jun . c Fos protein was increased in cells treated with C5a or high dose ( 200 microM ) H ( 2 ) O ( 2 ) , but not in cells treated with ADP . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CREB 2 and ATF 2 in nuclear extracts of unstimulated endothelial cells bound to CRE , whereas USF 2 and c Jun or c Fos bound to non CRE sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Alpha25 ( OH ) 2D3 interferes with retinoic acid induced inhibition of c fos gene expression for AP 1 formation in osteoblastic cells . ^^^ Our previous studies demonstrated retinoic acid ( RA ) inhibition of activation protein 1 ( AP 1 ) formation in TNF alpha treated osteoblastic MC3T3 E 1 cells via c fos suppression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of ERK1 / 2 resulted in induction of c jun , junB , and c fos expression , whereas activation of p 38 alone had no effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of connexin 43 expression by c fos and c jun in myometrial cells . ^^^ We constructed expression vectors for c Fos and c Jun to investigate the role of these transcription factors in the regulation of Cx 43 expression . ^^^ The combinations of c Fos and c Jun proteins activated the Cx 43 promoter while c Jun alone had no effect on Cx 43 promoter activity . ^^^ These data indicate that the transcription factors c Fos and c Jun are important in the regulation of Cx 43 expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of note , in OA chondrocytes , IL 17 and IL 1beta induced collagenase 3 production through AP 1 occurred with differential protein complexes : IL 17 stimulation resulted in FosB activation , while IL 1beta stimulated c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In normal astrocytes , LPA stimulates reactive oxygen species synthesis , activation of multiple protein kinases and expression of c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Short term treatment with 0 . 1 5 microM As ( 3 ) up regulates expression of c Fos and c Jun and the redox regulators , thioredoxin ( Trx ) and Redox factor 1 ( Ref 1 ) and activates both AP 1 and NF kappa B binding . ^^^ Chronic exposure to 0 . 1 or 0 . 5 microM As ( 3 ) decreased c Jun , c Fos and Ref 1 protein levels and AP 1 and NF kappa B binding activity , but increased Trx expression . ^^^ The different effects of short versus long term As ( 3 ) treatment on acute phase response to oxidative stress reflect changes in the expression of Ref 1 , c Fos and c Jun , but not Trx . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western data showed that NOx increased the expressions of c Fos , c Jun , and signaling kinases including MEKK 1 , JNK 1 , and p 38 ( with induction fold of 3 . 3 , 2 . 8 , and 3 . 2 , respectively ) in the cells 12 h after treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While the AP 1 ( activator protein 1 ) genes c fos and c jun have been implicated in the expression of myometrial genes associated with the onset of labor , there are no data concerning the role of other members of this family of transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The exposure of mammalian cells to UV irradiation induces the expression of immediate early genes such as c jun and c fos and activates the transcription factors AP 1 and NF kappaB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By comparing S100A8 and S100A9 mRNA levels in wild type and c Fos deficient mice ( c fos ( / ) ) we found that expression is negatively regulated by c Fos / AP 1 . ^^^ Glucocorticoids , which exhibit potent anti inflammatory and anti tumor promoting activities repressed TPA mediated S100A8 and S100A9 induction in wild type , but not in c fos ( / ) mice , thus identifying both genes as the first examples of AP 1 target genes whose repression of TPA induced transcription by glucocorticoids depends on c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cholinergic stimulation of rat acinar cells increases c fos and c jun expression via a mitogen activated protein kinase dependent pathway . ^^^ CCh induced time and dose dependent increases in the c fos and c jun early response genes , which were blocked by m 1 and m 3 inhibition but not by m 2 inhibition . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have characterized the effects of chronic clozapine and haloperidol treatments on the expression of fos ( c fos , fosB , fra 2 ) and jun ( c jun , junB , junD ) family genes in the rat forebrain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After various survival times , the expression of MAP 2 , brain derived neurotrophic factor ( BDNF ) , c jun , c fos , nerve growth factor ( NGF ) and HSP 70 was assessed by in situ hybridization of coronal brain sections with 35S labeled probes . ^^^ BDNF , NGF , and c jun were significantly upregulated in the hippocampus . c fos was detected in the hippocampus , cortex and striatum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased AP 1 was detected 2 hours after initiation of the inflammatory response in lung with a further increase by 4 hours , while AP 1 activation was found in alveolar macrophages 0 . 5 hour after onset of the inflammatory response . mRNAs and proteins for c fos , c jun , jun B , and jun D were all up regulated in whole lung tissues and in alveolar macrophages during acute lung injury induced by IgG immune complex deposition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An up regulation of COX 2 , c fos , and c jun , but not COX 1 , was observed around the lesion as well as in the neocortex 4 hr after the injection . ^^^ Our studies showed 1 ) that sPLA ( 2 ) selectively induced neuronal COX 2 ; 2 ) that this induction was delayed ( 4 hr after injection of sPLA ( 2 ) ) compared with that elicited by glutamate ( 2 hr after injection ) , suggesting different signaling ; and 3 ) that c fos and c jun were induced around the infarct area as soon as 2 hr after injection , but in other aspects followed a time course similar to that of COX 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A component of the UVB induced AP 1 complex , c fos , also was identified as a mediator of the signaling pathway that leads to AP 1 activation . ^^^ NDGA significantly inhibited UVB induced c fos and AP 1 transactivation . ^^^ In addition , NDGA was found to inhibit activity of phosphatidylinositol 3 kinase ( PI 3 kinase ) , a UVB inducible enzyme that contributes to the induced expression of c fos and AP 1 . ^^^ Therefore , NDGA prevents UVB induced c fos expression and AP 1 transactivation by inhibiting the PI 3 kinase signaling pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Going away from the ischaemic core different neurochemical processes are occurring by space and time . `` Immediate early response ' ' genes ( c fos , fos B , c Jun , krox 20 , 24 ) are activated , heatshock proteins ( hsp 70 , 72 , HSF , HSE , HIF ) , cytokines ( TNF alpha , IL 1 beta ) , inflammatory factors ( COX ) , adhesion and glial factors ( ICAM 1 , ELAM 1 , P selectin ) , vasoactive factors ( IL 6 , 10 , PAF ) , reactive oxigen radicals and connected factors ( O 2 , OH , NO , NOS , SOD ) are produced within minutes and hours . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When the c jun and c fos expression vectors were cotransfected with the RARbeta expression vector into MKN 45 cells , AP 1 activity was also obviously repressed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of triptolide on the proliferation of airway smooth muscle and the expression of c fos and c jun in asthmatic rats ] . ^^^ OBJECTIVE : To study the effect of triptolide on airway smooth muscle ( ASM ) proliferation and expressions of c fos and c jun in asthmatic rats . ^^^ The mRNA expression of c fos and c jun were examined by RT PCR and their protein expression by immunohistochemical method . ^^^ RESULTS : c fos and c jun mRNA and protein expressions of asthma groups A and five therapy groups ( C , D , E , F and G ) were significantly higher than those in the control group B ( P < 0 . 01 ) . ^^^ CONCLUSIONS : ASM proliferation is a feature of asthma . c fos and c jun may promote ASM proliferation in asthma . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To elucidate the role of AP 1 in CYP1A2 regulation , we transiently overexpressed c Jun and c Fos transcription factors in human hepatoma HepG 2 cells , and examined their influence on the CYP1A2 promoter activity by reporter gene assays . ^^^ Therefore , it is unlikely that the c Jun and the c Fos activate the CYP1A2 promoter through this AP 1 consensus like sequence in the PRB region . . ^^^ Cotransfection of the c Jun and the c Fos expression vectors increased the induced transactivation by five to six fold from the CYP1A2 promoter constructs . ^^^ However , deletion of the PRB element did not affect the degree of activation by the c Jun and the c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ultraviolet B ( UVB ) induction of the c fos promoter is mediated by phospho cAMP response element binding protein ( CREB ) binding to CRE and c fos activator protein 1 site ( FAP 1 ) cis elements . ^^^ The AP 1 complex formed in UVB irradiated HaCaT cells is specifically composed of c fos and Jun D . c Fos expression was induced in a manner that correlated with the UVB induced activation of AP 1 . ^^^ Clustered point mutations at the sis inducible element ( SIE ) , serum response element ( SRE ) , c fos AP 1 site ( FAP 1 ) , or cyclic AMP response elements ( CRE ) significantly inhibited UVB induction of the c fos promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Additionally , quantitative reverse transcriptase PCR analysis for levels of c jun and c fos in bronchiolar epithelium isolated by laser capture microdissection demonstrates increases in expression of these genes in asbestos exposed epithelial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We previously showed that gp 34 ( OX 40 ligand ) expressed on vascular endothelial cells is not only involved in adhesion between activated T cells and endothelial cells but also by itself able to transmit intracellular signals leading to expression of c fos and c jun mRNA upon OX 40 binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We also showed that GTE decreased c fos and c jun RNA transcripts , suggesting that activator protein ( AP ) 1 responsive regions present in the human VEGF promoter may be involved in the inhibitory effect of GTE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that the zinc finger region of BCL 6 interacts with c Jun , JunB , and JunD proteins but does not bind c Fos or Fra 2 proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift EMSA revealed that VT preferentially induced JunB , JunD , phosphorylated c Jun , c Fos , and Fra 2 binding activities of the AP 1 family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While both TGF beta 1 and PMA caused a transient increase in expression of the mRNAs for early response genes including c fos , c jun and egr 1 that peaked by 1 hour following treatment , the increase in expression of these mRNAs following treatment with AM peaked only after 3 6 hours . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The a smooth muscle actin ( alpha SMA ) expression in HSC was studied with confocal laser microscopy and flow cytometry . c fos , c jun and cyclin D ( 1 ) expression in HSC was also detected by flow cytometry . ^^^ The intensity of c fos , c jun and cyclin D ( 1 ) expression of HSCs treated with 10 ( 7 ) mol / L genistein for 48 h was also significantly decreased compared with the controls . ^^^ CONCLUSION : Genistein influences proliferation of HSC , suppresses the expression of alpha SMA in HSC and t inhibits the intensity of c fos , c jun and cyclin D ( 1 ) expression of HSCs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Protein substrates of the proteasome that are found concentrated in clastosomes include the short lived transcription factors c Fos and c Jun , adenovirus E1A proteins , and the PML protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This cellular response was the result of TH promoter activation , via c fos and Jun D binding at the AP 1 responsive element . ^^^ The two pathways exert distinct roles ; whereas nitric oxide synthase inhibitors blocked c fos expression , protein kinase C inhibitors blocked that of Jun D . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Whereas TPA treatment resulted in a strong induction of p 21 ( WAF / CIP1 ) , c Fos and c Jun levels , neither one of the novel PKC activators altered expression of these proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using transgenic mice expressing an N terminal portion of mutant huntingtin ( R6 / 2 mice ) , we have examined immediate early gene ( IEG ) expression as an index of dopaminergic signal transduction . c fos , jun B , zif 268 , and N 10 mRNA levels and expression patterns were analyzed using quantitative in situ hybridization histochemistry following intraperitoneal administration of selective D 1 and D 2 family pharmacological agents ( SKF 82958 and eticlopride ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using a model system of in vitro human peripheral blood lymphocytes , the effect of low dose ( 0 . 25 to 1 . 50 Gy ) 250 kVp 10 ray radiation ( 1 Gy . min 1 ) on the expression of several proto oncogenes was examined ( c Haras , c src , c met , c jun , c fos , and c myc ) and beta actin from 0 . 25 to 17 h post radiation . ^^^ A progressive time and dose dependent increase in mRNA levels was observed for c Haras mRNA , while the other proto oncogenes ( c src , c met , c fos , c jun and c myc ) examined were variable during the same time period . beta actin levels were initially decreased but at 17 h post radiation had returned to control levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of protein kinase A or the transcription factor cAMP response element binding protein blocks the stimulation of both promoters by mutant receptors , whereas inhibition of activating transcription factor 2 , c Fos , or c Jun has only minor effects . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Competition and gel mobility supershift assays identify upstream stimulatory factor ( USF ; USF 1 : USF 2 ) and activator protein 1 ( AP 1 ; c Fos : c Jun ) in complexes binding the composite CCTCATGAC element . ^^^ Moreover , glucose stimulates the transactivation functions of c Fos and USF 1 , but not c Jun , in one hybrid assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blot analysis showed that the homocysteine induced decrease in promoter activity was not associated with reduced expression of the AP 1 components c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased Notch 1 signaling , but not Notch 2 , causes a dramatic down modulation of HPV driven transcription of the E6 / E7 viral genes , through suppression of AP 1 activity by up regulation of the Fra 1 family member and decreased c Fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this work we investigated the effect of measles virus ( MV ) infection on the expression of immediate early genes junB , c jun and c fos mRNA as well as AP 1 DNA binding activity in the lung epithelial like adenocarcinoma cell line A 549 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Significant elevations in c fos and c jun mRNA levels were observed within 30 min after exposure to arsenic and by enhancement of AP 1 DNA binding activity and transactivation activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c Fos proteins form heterodimeric proteins with the c Jun family proteins and the resulting AP 1 transcription complex plays a key role in coupling short term events elicited by stimuli received at the cell membrane to long term neuroplastic changes by regulating gene expression . c fos is induced in the hippocampus after spatial learning . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Prostaglandin F2alpha induced nest building behaviour is associated with increased hypothalamic c fos and c jun mRNA expression . ^^^ In this experiment , we examined hypothalamic expression of the immediate early genes c fos and c jun mRNA after treatment with PGF2alpha or cloprostenol . ^^^ Coronal hypothalamic sections and control ovarian tissues were incubated with 45 mer oligonucleotide probes complementary to porcine c fos and c jun genes using standard in situ hybridization histochemistry techniques . ^^^ Significantly higher c fos and c jun mRNA expression was found in PGF2alpha treated compared to saline or cloprostenol treated pigs in the PVN , SON and SOD . ^^^ Significantly higher c fos and c jun mRNA expression was found in corpus lutea of PGF2alphaand cloprostenol treated pigs compared to saline controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibitory effect of glycolic acid on ultraviolet B induced c fos expression , AP 1 activation and p 53 p21 response in a human keratinocyte cell line . ^^^ We also investigated whether glycolic acid could inhibit UVB induced alternation of cell cycle , c fos expression and activation of transcription factor AP 1 in cultured immortalized human keratinocyte HaCaT cells . ^^^ Glycolic acid also inhibited the UVB induced expression of c fos and the activation of transcription factor AP 1 , and inhibited mRNA levels of apoptosis regulatory gene ( p 53 and p 21 ) . ^^^ These results suggest that glycolic acid may exert the inhibitory effect on the UVB induced skin tumor development by blocking the UVB induced of apoptosis and cytotoxicity through inhibition of c fos expression and activation of AP 1 in addition to the inhibition of p 53 p2l response pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of early response gene proteins c Fos , c Jun , and GAP 43 and their association with 6 hydroxydopamine ( 6 OHDA ) mediated oxidative injury were investigated using catecholaminergic PC 12 cell line . ^^^ Significant induction in the expression of c Fos ( P < 0 . 01 ) , c Jun ( P < 0 . 001 ) and GAP 43 ( P < 0 . 05 ) was observed following 2 h exposure to 6 OHDA ( 10 ( 6 ) M ) , which persisted during 24 h of observation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NRC is a 2 , 063 amino acid nuclear protein which contains a potent N terminal activation domain and several C terminal modules which interact with CBP and ligand bound nuclear hormone receptors as well as c Fos and c Jun . ^^^ Although NIF 1 does not directly interact with nuclear receptors , it markedly enhances ligand dependent transcriptional activation by nuclear hormone receptors in vivo as well as activation by c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast to serum , however , ouabain failed to activate the Elk 1 , serum response factor , CREB and activator protein 1 transcription factors identified within the c Fos promoter . ^^^ Incubation of VSMC with ouabain resulted in rapid induction of c Fos protein expression with an approximately sixfold elevation after 2 h of incubation . c Jun expression was increased by approximately fourfold after 12 h , whereas expression of activating transcription factor 2 , cAMP / Ca ( 2+ ) response element binding protein ( CREB ) 1 and c Myc was not altered . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These actions were dependent upon the activation of multiple MAPK signal pathways , including ERK 5 kinase ; transactivation of the epidermal growth factor receptor ; and the increased expression and activities of transcription factors ELK 1 , activating transcription factor 2 , c Fos , c Jun , activator protein 1 , and myocyte enhancer factor 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Relations of transcription expression of IL 2 with nuclear factor of activated T cells as well as changes of C Fos and C Jun after trauma . ^^^ OBJECTIVE : To observe the relations among expression of interleukin 2 ( IL 2 ) in spleen lymphocytes , DNA binding activity of nuclear factor of activated T cells ( NFAT ) and expression of the partly family members C Fos , C Jun after trauma . ^^^ Nuclear protein was extracted , and the DNA binding activity of NFAT was measured using an electrophoretic mobility shift assay ( EMSA ) , the expressions of C Fos , C Jun protein determined by Western blot analysis . ^^^ An decrease in the expression of C Fos on the 1st and 4th day after injury , trauma had no significant effect on the C Jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest that proENK mRNA expression induced by repeated nicotine administrations may be mediated by AP 1 proteins , such as c Fos , c Jun and Fra 2 rather than CREB via interacting to the ENKCRE 2 DNA binding domain in rat adrenal medulla . . ^^^ Additionally , repeated administrations of nicotine transiently induced the c fos and c jun mRNA levels after the first third nicotine administration , and the c fos and c jun mRNA levels were returned to the basal level after the seventh administration of nicotine . c Fos , c Jun and Fra 2 protein levels were persistently increased until the seventh administration . ^^^ Immunohistochemical analysis showed that the increase of c Fos and c Jun proteins by repeated nicotine administrations is mostly medulla specific , while Fra 2 immuno reactivity was shown both in medulla and cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blotting revealed that stress for 3 hr induced significant increases in expression of the components of AP 1 complex , c Fos , c Jun , and Jun B proteins , in adrenals , without markedly affecting expression of Fos B , Fra 2 , and Jun D proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transfection with sense PKB cDNA promoted c fos and c jun expression in 7721 cells , suggesting that ROS may regulate c fos and c jun expression via the PKB pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phosphorylation of the N terminal domain of Jun by the Jun kinases ( JNKs ) modulates the transcriptional activity of AP 1 , a dimeric transcription factor typically composed of c Jun and c Fos , the latter being essential for osteoclast differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As the MMTV promoter contains several putative AP 1 binding sites , we hypothesized that AP 1 , a transcription factor composed of c jun and c fos proteins , might be involved in the TGF beta inhibition of GR functions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Data obtained from knockout mice revealed that some components , such as c Fos are key regulators of bone cell differentiation , whereas others , like c Jun , JunB and Fra 1 are essential in embryonic and / or postnatal development . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The oncoproteins c Fos and c Jun create a transcriptional site early response activating protein ( AP 1 ) mediating the regulation of gene expression in response to extracellular signalling by , for example , cytokines . ^^^ In the present study we visualize the AP 1 transcriptional site factors c Fos and c Jun in 38 human herniated intervertebral disc tissue samples by immunohistochemical staining with monoclonal antibodies . ^^^ Oncoprotein c Fos and c Jun immunopositive cells and cell clusters in herniated intervertebral disc tissue . ^^^ Furthermore , c Jun immunoreactivity was also observed in disc cell clusters , thus demonstrating them to be active transcriptional sites in disc tissue . c Fos immunoreactivity was seen in 15 / 38 and c Jun in 28 / 38 herniated discs ( 39 % and 74 % respectively ) . ^^^ Furthermore , we did not notice any statistical difference regarding the immunoreaction for proto oncogenes c Fos and c Jun in extrusions , sequesters and protrusions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These studies reveal the presence of Tax , a variety of ATF / CREB and AP 1 family members ( CREB , CREB 2 , ATF 1 , ATF 2 , c Fos , and c Jun ) , and both p 300 and CREB binding protein at the HTLV 1 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These effects were associated with the decrease in levels of c fos and c jun mRNA in primary astrocyte cultures exposed to 24 h ischemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of immediate early genes c fos and c jun in the marginal division of striatum during learning and memory . ^^^ OBJECTIVE : To study the expression of immediate early genes c fos and c jun in the marginal division ( MrD ) of rat striatum during learning and memory . ^^^ METHODS : After Y maze training in rats , the expression of immediate early genes c fos and c jun in the MrD was investigated immunocytochemically . ^^^ RESULTS : After 1 h of Y maze training , the expression of c Fos and c Jun proteins was significantly enhanced in the MrD , where c Jun protein in particular was more intensely expressed than in other parts of the striatum . ^^^ CONCLUSION : Immediate early genes c fos and c jun in the MrD participate in the signal transduction during learning and memory processes in the courses of Y maze training of the rats . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proteins of the immediate early genes c Fos and c Jun are thought to be involved in coupling neuronal excitation to target gene expression , due to formation of heterodimers and binding to the AP 1 promotor region . ^^^ MK 801 attenuates c Fos and c Jun expression after in vitro ischemia in rat neuronal cell cultures but not in PC 12 cells . ^^^ We used an in vitro model to compare ischemia induced c Fos and c Jun expression in rat neuronal cell cultures and nerve growth factor ( NGF ) differentiated PC 12 cells . ^^^ Since activation of glutamate receptors is known to mediate ischemic injury we determined the effect of the noncompetitive N methyl D aspartate ( NMDA ) receptor antagonist MK 801 on c Fos and c Jun expression in both cell culture systems during ischemia . ^^^ C Fos and c Jun mRNA expression was analyzed by competitive reverse transcription polymerase chain reaction using glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) as internal standard . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , we observed significant time dependent increases in the expression of the c fos and c jun proto oncogenes after addition of IGF 1 ( n = 5 per group , P < . 05 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos , rather than c jun or glucocorticoid receptor mRNA , correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma . ^^^ In order to investigate the mechanism ( s ) underlying the individual differences of lymphocyte GC response , we examined the relationship between lymphocyte sensitivity to GC in vitro and the expression of mRNAs for GC receptor ( GR ) alpha , GRbeta , c fos and c jun , which are reported to be implicated in the regulation of the pharmacological effects of GCs in asthma patients . ^^^ Transcripts for GRalpha , c fos , c jun and beta actin genes in PBMCs were quantitatively determined by reverse transcription competitive polymerase chain reaction ( RT cPCR ) procedures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of LNCaP cells with EGF resulted in a transient increase in the expression of both c Fos and c Jun . ^^^ Addition of clusterin to these cultures significantly down regulated the protein level of c Fos , but not c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The decline in DNA binding activity of NFAT and AP 1 is partly due to a trauma induced block in the expression of c Fos . . ^^^ The expression of c Fos , c Jun and JunB proteins was determined by the Western blot analysis . ^^^ A decrease in the expression of c Fos on the 1st and 4th day after trauma had no significant effect on c Jun expression ; the increase in expression of JunB was only on the 1st day after injury . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Due to the presence of IP 3 receptors both in the SR ( A band region ) and in the nuclear envelope , these two events appear to be related ; 3 ) Phosphorylation of mitogen activated kinases ( ERK 1 / 2 ) and of the transcription factor CREB ( 30 s 10 min ) , as well as expression of the early genes c fos , c jun and egr 1 mRNA ( 5 15 min ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dentin bonding agents induce c fos and c jun protooncogenes expression in human gingival fibroblasts . ^^^ It has been shown that c fos and c jun are induced rapidly by a variety of chemical and physical stimuli . ^^^ Therefore , we used primary human gingival fibroblasts to examine the effect of six dentin bonding agents on the expression of c fos and c jun protooncogenes to evaluate the genotoxicity / mutagenicity and cacinogenicity potential of the dentin bonding agents . ^^^ The levels of mRNA were measured by the quantitative RT PCR analysis . c fos and c jun mRNA expression in dentin bonding agents treated cells revealed a rapid accumulation of the transcript , a significant signal first was detectable after 1h of exposure . ^^^ Persistent induction of c jun and c fos protooncogenes by dentine bonding agents may distribute systemically to cause some unexpected adverse effects on human beings . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using in situ hybridization it was found that L DOPA treated animals exhibited a pronounced induction in the gene expression of both c jun and c fos in striatum and cerebral cortex restricted to the dopamine depleted hemisphere . ^^^ In contrast , acute treatment with cocaine induced c fos mRNA , but not c jun mRNA , in the striatum of normal animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gene disruption studies indicate that the AP 1 family members c jun , junB , and fra 1 are essential for embryonic development , whereas junD , c fos , and fosB are required for normal postnatal growth . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further , expression of c Jun and c Fos proteins and activator protein ( AP 1 ) DNA binding activity were enhanced in a time dependent manner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A dimer of the basic region leucine zipper proteins c Jun and c Fos constitutes the classical activator protein 1 ( AP 1 ) transcription factor . c Jun is thought to play essential roles in many important cellular pathways , including the control of proliferation and cell death . ^^^ To investigate the roles of c Jun and c Fos concentrations in the regulation of neuronal cell death , we generated conditional alleles by fusing c Jun and c Fos to the ligand binding domain of the murine estrogen receptor ( ER ) , with the aim of controlling the biological activities of c Jun and c Fos by the synthetic ligand 4 hydroxytamoxifen ( 4OHT ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CCY1a as well as PD 98059 almost completely abolished serum induced activation of p42 / 44 mitogen activated protein kinase ( MAPK ) , the downstream effectors of c fos and c jun mRNA expression and activator protein 1 ( AP 1 ) DNA binding activity , suggesting the central roles of these signaling cascades . ^^^ We conclude that CCY1a blocks cell proliferation via inhibition of the upstream effector of Ras and downstream events , including p42 / 44 MAPK activation and c fos and c jun mRNA expression , as well as NF kappa B and AP 1 DNA binding activities . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our results show that IL 2 activates CREB in human NK cells and that CREB activation hasa prominent regulatory role on the IL 2 induced expression of functional c fos and AP 1 in NK cells . ^^^ Our results show that CREB has a relevant role in the cytokine mediated activation of NK cells , and are particularly remarkable in the light of the several genes that are positively regulated by c fos and AP 1 , such as IFN gamma , IL 2 and GM CSF genes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The suppression of various tumor biomarkers including growth factor receptor tyrosine kinases , cytokine receptor kinases , PI3K , phosphatases , ras , raf , MAPK cascades , N 10 FB , 1 10 B kinase , PKA , PKB , PKC , c jun , c fos , c myc , cdks , cyclins , and related transducing proteins by tea polyphenols has been studied in our laboratory and others . ^^^ The mechanisms of this inhibition may be due to the blockade of the mitogenic and differentiating signals through modulating EGFR function , MAPK cascades , NFkappaB activation as well as c myc , c jun and c fos expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrated that c Fos , c Jun , and JunD are involved in TPA inhibitory effect due to their ability to bind TRE ALAS , evidenced by supershift analysis and their capacity to repress promoter activity in transfection assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays demonstrated that c Jun , c Fos and ATF 2 are part of the AP 1 complex , indicating that activated c Jun is dimerized with c Fos or ATF 2 for control of its target gene expression . ^^^ Our results suggest strongly that human amylin induces apoptosis through stimulation of expression and activation of c Jun , and that co expression and dimerization of c Jun and c fos or ATF 2 may be important for activation of the downstream apoptotic process . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further EMSA analysis using antibodies to various AP 1 components revealed that junB antibodies partially depleted the increase in binding to the PRE 1 seen in UK / rap1 cells while antibodies to other AP 1 constituents such as c jun , c fos , and ATF 1 had no effect on binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ginsenosides inhibit EGF induced proliferation of renal proximal tubule cells via decrease of c fos and c jun gene expression in vitro . ^^^ This study investigated the effect of total ginsenosides , protopanaxatriol ( PT ) saponin , and protopanaxadiol ( PD ) saponin fraction on epidermal growth factor ( EGF ) induced renal cell proliferation and , furthermore , c fos and c jun gene expression . ^^^ In addition , the EGF induced increase of c fos and c jun gene expression was completely blocked by total ginsenosides and partially by PT and PD saponins . ^^^ In conclusion , ginsenosides , in part , inhibit EGF induced cell proliferation via decrease of c fos and c jun gene expression in primary cultured rabbit renal proximal tubular cells ( PTCs ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Dominant negative mutants of Nrf 2 and Maf , but not of c Fos and c Jun , inhibited basal and heme induced expression of an E 1 controlled luciferase gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inflammation is associated with up regulation , phosphorylation , and nuclear translocation of c fos , which then represses ASBT promoter activity via binding of the 3 ' AP 1 element by a c fos / c jun heterodimer . . ^^^ RESULTS : Indomethacin induced ileitis in Lewis rats leads to specific reductions in ileal ASBT messenger RNA and protein levels , whereas c jun and c fos are induced . ^^^ The 5 ' site binds a c jun homodimer , whereas the 3 ' site binds a c jun / c fos heterodimer . c Jun overexpression enhances ASBT promoter activity , whereas a dominant negative c jun construct inactivates the promoter . c Fos overexpression represses promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Age dependent differences in flurothyl induced c fos and c jun mRNA expression in the mouse brain . ^^^ In the immature mouse , neither c fos nor c jun mRNA were statistically elevated following any type of acute seizure activity . ^^^ In the mature mouse , seizures of different severity resulted in differential effects on regional c fos and c jun mRNA expression . ^^^ We conclude that the c fos and c jun are not reliable indicators of seizure activity in immature mice , whereas they remain indirect markers of neuronal activity in mature mice . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Palytoxin stimulated an increase in c Fos binding to the activator protein 1 ( AP 1 ) site present in the promoter of the mouse MMP 13 gene . ^^^ PD 98059 also blocked the palytoxin stimulated increases in c Fos protein levels , c Fos binding to the AP 1 site , and MMP 13 mRNA . ^^^ Specifically , our data suggest that , in keratinocytes derived from initiated mouse skin , ERK plays an important role in transmitting palytoxin stimulated signals to three downstream targets that are likely to affect carcinogenesis : c Fos , AP 1 , and MMP 13 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of interest , we detected a significant decrease of NF kappaB , AP 1 , and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides ( NF kappaB , AP 1 , and CREB ) or Abs against various transcription factor subunits ( p 50 , p 65 , c Fos , Jun B , c Jun , and CREB 1 ) were added . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phosphorylated c Jun , JunB , JunD , and Fra 1 , but not c Fos , FosB , or ATF 2 , are detected in the AP 1 DNA binding complex in cells exposed to trivalent arsenicals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we investigated the role of the AP 1 family members c Jun and c Fos in transcriptional regulation of the JC virus ( JCV ) promoter in glial cells . ^^^ Further functional assays indicated that the JCV AP 1 binding site is sufficient to confer responsiveness to both c Jun / c Fos and UV induced activation when transposed to a heterologous promoter . ^^^ Functional analysis of the promoter showed that ectopic expression of c Jun and c Fos results in an additive activation of the JCV early and late promoters . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CONCLUSION : Octreotide inhibits not only ERK 1 / ERK 2 and c Fos expressions but also AP 1 binding activity , which result in inhibition to proliferation of gastric carcinoma cell . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Though there is evidence that c Fos can be ubiquitinylated in vitro , the unambigous demonstration that prior ubiquitinylation is necessary for degradation by the proteasome in vivo is still lacking . c Jun , one of the main dimerization partners of c Fos within the AP 1 transcription complex , is also an unstable protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcriptional regulation of dentin matrix protein 1 ( DMP 1 ) by AP 1 ( c fos / c jun ) factors . ^^^ This study demonstrates the role of c fos and c jun on the transcriptional regulation of DMP 1 gene . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A canonical activation ( increased phosphorylation of mitogen activated protein kinase kinase 4 , c Jun N terminal kinase , and c Jun ) of the AP 1 pathway was found in Atm deficient cerebra , whereas induction of the AP 1 pathway in Atm deficient cerebella is likely to mediate elevated expression of c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine whether c Fos and c Jun are involved in the repair of small intestinal mucosa after ischemia reperfusion ( I / R ) , we investigated the mechanism of regeneration following acute I / R injury in rats by evaluating changes in DNA synthesis , fractional synthesis rate ( FSR ) of proteins , and alkaline phosphatase ( ALP ) activity . ^^^ Furthermore , we examined the sequential expression of c Fos and c Jun using western blot analysis and immunohistochemical staining . ^^^ The expression of c Fos and c Jun proteins increased markedly after I / R and these proteins decreased with time . ^^^ These results indicate that c Fos and c Jun play a central role in the repair process that results in complete restoration of intestinal mucosal function after I / R . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun protooncogenes in the uteri of immature mice neonatally exposed to diethylstilbestrol . ^^^ We studied the cell type specific and temporal expression of c fos and c jun protooncogenes after 17beta estradiol ( E 2 ) stimulation in the uteri of immature 3 week old mice neonatally exposed to diethylstilbestrol ( DES ) , DES mice , and the ontogenic expression of these genes in the uteri of DES mice using immunohistochemistry and in situ hybridization . ^^^ The changes in the expression of c fos and c jun protooncogenes , particularly during postnatal development , are likely to play important roles in the production of uterine abnormalities in the DES mice . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In normal myotubes , 10 micro M nifedipine , but not ryanodine , inhibited c jun and c fos mRNA increase after K ( + ) depolarization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Six proto oncogenes ( K ras , c myc , c fos , c jun , c sis , and erbB ) , as well as the p 53 tumor suppressor , were investigated for gene amplification using differential polymerase chain reaction ( PCR ) , while the expression of the proteins produced by these genes was evaluated by Western blot analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Suppression of insulin induced AP 1 transactivation by menin accompanies inhibition of c Fos induction . ^^^ We found that menin suppressed c Fos induction at the transcriptional level , although that can not explain the entire mechanism of AP 1 suppression by menin . ^^^ Menin did not alter the expression levels of AP 1 proteins except c Fos , phosphorylation of c Jun and JunD and DNA binding properties of AP 1 proteins . ^^^ Suppression of AP 1 activation by menin may be exerted through 2 independent mechanisms , direct inhibition on AP 1 mediated transcription and suppression of c Fos induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of cadmium on the expression of proto oncogene c fos and c jun of liver cell in rats ] . ^^^ The effects of cadmium chloride on the expression of proto oncogene c fos and c jun of rat liver cells were studied with Northern dot hybridization . ^^^ The results showed that at the dose of 5 , 10 or 20 mumol / kg of cadmium chloride , the expression of proto oncogene c fos and c jun could be induced obviously . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , both MK 801 and CNQX partially reduced the increased c Fos and c Jun protein expression in hippocampus induced by KA . ^^^ Furthermore , c Fos and c Jun proteins may serve as third messengers responsible for CA 3 pyramidal cell death induced by supraspinally administered KA . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report that the promoter proximal activator protein 1 ( AP 1 ) site is essential for the response of both Timp 1 and MMP 1 to TGF beta ( induction and repression , respectively ) . c Fos , JunD , and c Jun are essential for the induction of Timp 1 gene expression by TGF beta 1 , but these AP 1 factors transactivate equally well from both Timp 1 and MMP 1 AP 1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We now describe the calcium dependence of P CREB and P ERK induction and of the increases in mRNA of the early genes c fos , c jun , and egr 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of activation of p MAPK on activating c fos and c jun proteins in breast cancer ] . ^^^ METHODS : Immunohistochemical technique was used to detect the expression of p MAPK and c fos and c jun proteins in 68 cases of breast cancers , 42 cases of pericarcinomatous tissues and 7 cases of normal breast tissues . ^^^ RESULTS : Positive stainings of p MAPK , c fos , and c jun were localized in cancer cell nuclei . ^^^ The positive rates of p MAPK , c fos , and c jun were 86 . 8 % ( 59 / 68 ) , 82 . 4 % ( 56 / 68 ) , and 77 . 9 % ( 53 / 68 ) , respectively , which were much higher than that in pericarcinomatous tissues ( P < 0 . 01 ) . ^^^ CONCLUSION : Activated or overexpressive MAPK activates the immediately early oncogenes ( c fos , c jun ) , which might play an important role in carcinogenesis of breast cancer and be an early event of oncogenesis of breast cancer . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of Stat 3 phosphorylation and expression of c fos and c jun proteins on hepatocarcinogenesis ] . ^^^ Expression of phosphorylated Stat 3 ( p Stat 3 ) , c fos and c jun proteins was detected by immunohistochemical technique in 55 hepatocellular carcinomas ( HCC ) and their surrounding liver tissues . ^^^ The results showed that the positive rates and signal intensity of p Stat 3 , c fos and c jun protein in HCCs were significantly higher than those in pericarcinomatous tissues . ^^^ The expressive intensity of c fos and c jun proteins was positively related to p Stat 3 expression in HCCs , whereas the positive correlation of expressive intensity was only observed between c jun protein and p Stat 3 in pericarcinomatous tissues . ^^^ The data suggest that the phosphorylation of Stat 3 may be an early event in hepatocarcinogenesis ; the overexpression of p Stat 3 protein , which activates c fos and c jun genes , may contribute to malignant transformation of hepatocytes ; hepatocytes which expressed p Stat 3 , c fos or c jun proteins may be potentially malignant pre cancer cells in pericarcinomatous liver tissues . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Notably , we have found increased expression of transcription factors c fos and c jun down stream of extracellular signal related kinase , a pathway which is crucial for virus replication and pathogenesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Tumor promoter arsenite stimulates histone H 3 phosphoacetylation of proto oncogenes c fos and c jun chromatin in human diploid fibroblasts . ^^^ We have shown previously that arsenite can potently activate the mitogen activated protein kinase cascades and induce the expression of proliferation associated genes , including proto oncogenes c jun and c fos . ^^^ In order to elucidate further the molecular mechanisms underlying its tumor promoting properties , we investigated the signaling events involved in arsenite mediated induction of c fos and c jun . ^^^ We found that induction of both c fos and c jun by arsenite can be substantially inhibited by the MEK selective inhibitor U 0126 , suggesting that the ERK pathway is critically involved in their up regulation . ^^^ Interestingly , arsenite dramatically induced the phosphorylation and acetylation of histone H 3 preceding the induction of mRNAs encoding c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The PCB effects were studied by semiquantitative RT PCR analysis of AhR target genes ( cytochrome P 450 ( CYP ) 1A1 , 1A2 , UDP glucuronosyl transferase 1 , glutathione S transferase pi 1 and aldehyde dehydrogenase ) and dioxin responsive genes ( IL 1beta , PAI 2 , Cox 2 , TGFalpha , EGF , erbB 1 4 , c fos , c jun , HSP 90 , cyclophilin 40 ) , and by differential display ( DD ) RT PCR . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The amount of PU . 1 increased throughout maturation whereas the level of Elf 1 reached a nadir in MCs / MMs The PU . 1 coactivator c jun and c jun ' s dimerization partner c fos were both detectable in MCs / MMs and increased in amount with maturity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The systemic administration of NMDA at 100 mg / kg resulted in marked expression of c Fos , Fra 2 and c Jun proteins in the granule cell layers of the dentate gyrus in murine hippocampus 2 h later , followed by a significant reduction of the incorporation of 5 bromo 2 ' deoxyuridine ( BrdU ) in a manner sensitive to the antagonist dizocilpine 2 days after administration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since MMP 9 expression by CTB is a prerequisite for matrigel invasion and since the promoter region of the MMP 9 gene contains two AP 1 binding sites , we hypothesized , that transient activation of c jun and c fos oncogenes ( which bind to form AP 1 ) by tumour necrosis factor ( TNFalpha ) , or the phorbol ester TPA will promote the invasive phenotype of CTB and induce the production of MMP 9 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Damage , repair , and transcription of the c FOS gene are presented here as examples , because Fos peptide , one of the components of activator protein 1 , activates nerve growth factor and repair mechanisms . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Prolonged expression of c Fos and c Jun in the cerebral cortex of rats after deltamethrin treatment . ^^^ In this study we investigated the effects of deltamethrin on the expression of c Fos and c Jun in the cerebral cortex of rats . ^^^ The immunostaining for c Jun was also dramatically elevated in the same brain region , showing the same time course of c Fos expression after deltamethrin treatment . ^^^ Further , both MK 801 , an N methyl D aspartate ( NMDA ) receptor antagonist , and NBQX , an alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) / kainate ( KA ) receptor antagonist , attenuated deltamethrin elicited prolonged expression of c Fos and c Jun . ^^^ Since the persistent expression of c Fos and c Jun is unusual , and has been reported before in conditions involving neurodegeneration , our results are consistent with a model that deltamethrin induces neurodegeneration through a glutamate dependent pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blotting analysis for AP 1 subunits indicated that c Fos was similarly expressed in wild type and PARP 1 deficient cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
VIP binds with high affinity to cancer cells , elevates the cAMP and increases gene expression of c fos , c jun , c myc and vascular endothelial cell growth factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Picroliv significantly down regulated the stress sensitive transcription factor AP 1 and decreased the level of c fos mRNA as well as c jun and c fos proteins in liver tissue , indicating that its actions could be mediated through AP 1 and associated signal transduction pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has been established that the collagenase gene can be activated by c Jun and c Fos and that the transcriptional coactivator p 300 is involved in the activation . ^^^ Strikingly , the first modification observed is methylation of histone H 3 lysine 4 , which correlates with the binding of the SET 9 methyltransferase and the assembly of a complex consisting of c Jun , c Fos , TATA binding protein , and RNA polymerase 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the other hand , expressions of proto oncogene c jun , junB and c fos were induced by TPA and Saikosaponin a during 30 min to 6 h of treatment . ^^^ Inductions of c fos RNA by both drugs and c jun phosphorylation by TPA were also significantly reduced by PD 98059 pretreatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We now report Stx 1 induction of both primary response genes c jun and c fos and activation of the stress activated protein kinases , JNK / SAPK and p 38 , in the intestinal epithelial cell line HCT 8 . ^^^ By 1 h of exposure to Stx 1 , mRNAs for c jun and c fos are induced , and both JNK and p 38 are activated ; activation of both kinases persisted up to 24 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Most AP 1 factors predominated in the nuclear fraction with notable exceptions . c Fos predominated in the nucleus in GC and follicles but predominated in the cytoplasmic fraction of CL . ^^^ Nuclear extracts from granulosa cells from 1 2 mm or 8 10 mm antral follicles bound an AP 1 DNA consensus sequence and complexes consisted predominantly of c Jun , JunD , JunB , c Fos , and Fra 2 . ^^^ Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^ The intensities of c Jun and c Fos protein bands were decreased in CL WCE compared to antral follicles . ^^^ In CL , c Jun , JunD , JunB , and Fra 2 were present in DNA binding complexes , and c Fos binding was not detected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In situ hybridization using oligonucleotide probes was used to study the effects of intrastriatal microinjection of corticoliberin on the expression of the early genes c fos , jun B , c jun , and NGFIA in the rat brain . ^^^ Administration of corticoliberin ( 0 . 25 microg ) into the neostriatum induced the expression of mRNA encoded by the early genes c fos , jun B , and NGFIA in both the neostriatum itself and in its efferent structures , particularly the nucleus accumbens and various parts of the cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MEK 5 is a specific activator of ERK 5 . c Fos and Fra 1 , well known immediate early gene products , are members of the AP 1 family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , Rg ( 3 ) exerted potent inhibitory effects on the activation of another transcription factor , activator protein 1 ( AP 1 ) that is responsible for c jun and c fos oncogenic transactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In concert , the proapoptotic signals mediated by JNK l and c fos proteins were also reduced suggesting that the novel cardioprotective properties of GSPE may be at least partially attributed to its ability to block anti death signaling mediated through the proapoptotic transcription factors and genes such as JNK 1 and c JUN . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Its protein product , c Fos , is a short lived transcription factor that heterodimerizes with various protein partners within the AP 1 transcription complex via leucine zipper / leucine zipper interactions for binding to specific DNA sequences . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
During the TRAF 6 and c Src induced AP 1 activation , phosphatidylinositol 3 ( PI 3 ) kinase , its downstream signaling molecule , Akt and c Jun N terminal kinase ( JNK ) were significantly activated and inhibition of these kinase activities down regulated AP 1 activation through the suppression of c fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Many known substrates of the different calpain isoenzymes , such as the transcription factors c Fos and c Jun , the tumour suppressor protein p 53 , protein kinase C , pp60src , or the adhesion molecule integrin , have been implicated in the pathogenesis of various malignancies including squamous ( SCC ) and basal ( BCC ) cell carcinomas of human skin , suggesting an important role of the calpain isoenzymes in malignant diseases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Meanwhile , activation of ERK1 / 2 , phosphorylation of the Elk 1 transcription factor , and , consequently , a substantial elevation of Egr 1 and c Fos levels and AP 1 DNA binding were observed . ^^^ Moderate elevation of [ Ca2+ ] 1 , on the other hand , caused a delayed monophasic activation of ERK1 / 2 and Elk 1 that was accompanied with only a small increase of Egr 1 and c Fos levels and AP 1 DNA binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study was designed to examine in bovine luteal cells ( 1 ) activation of the extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase ( MAPK ) signaling cascade ( Raf / MEK / ERK ) by EGF ; ( 2 ) mRNA expression of AP 1 transcription factors , i . e . c fos and c jun , in response to EGF ; and ( 3 ) the role of ERK in EGF induced expression of c fos and c jun mRNA . ^^^ Epidermal growth factor induces c fos and c jun mRNA via Raf 1 / MEK1 / ERK dependent and independent pathways in bovine luteal cells . ^^^ EGF rapidly and transiently stimulated the expression of c fos and c jun mRNA in bovine luteal cells . ^^^ Maximal induction of c fos and c jun mRNA by EGF occurred within 30 min of treatment with 10 ng / ml EGF . ^^^ However , blocking EGF induced ERK activation by pretreatment with PD 098059 only partially attenuated EGF induced c fos and c jun mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increasing concentrations of the PD 98059 inhibitor in long term monolayer or micromass cultures ( 2 . 5 day ) resulted in differential regulation of c Fos and c Jun protein levels as well as total expression and phosphorylation levels of ERK1 / 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
D 3 stimulates activator protein 1 DNA binding activity by a phosphatidylinositol 3 kinase / Ras / MEK / extracellular signal regulated kinase 1 / 2 and c Jun N terminal kinase 1 dependent increase in c Fos , Fra 1 , and c Jun expression in human keratinocytes . 1alpha , 25 Dihydroxyvitamin D 3 added to human keratinocytes increases differentiation through an activation of the transcription factor activator protein 1 . ^^^ Western blotting experiments revealed that 1alpha , 25 dihydroxyvitamin D 3 caused a rapid and transient activation of the mitogen activated protein kinases , extracellular signal regulated kinase 1 / 2 and c Jun N terminal kinase 1 . 1alpha , 25 Dihydroxyvitamin D 3 also enhanced the expression of the activator protein 1 subunits , c Fos , Fra 1 , and c Jun as determined by northern and western blotting . ^^^ Taken together , our results indicate that 1alpha , 25 dihydroxyvitamin D 3 , via binding to the membrane receptor annexin 2 , induces activation of the phos phatidylinositol 3 kinase / Ras / MEK / extracellular signal regulated kinase 1 / 2 and c Jun N terminal kinase 1 signal transduction pathway resulting in increased expression of c Fos , Fra 1 , and c Jun , and subsequently increased activator protein 1 DNA binding activity and gene transcription . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among the early response genes analyzed , c myc , junB , junD , c jun , c fos , fosB , fra , as well as max , mad 1 4 , sin 3 , only c jun and fra 2 mRNAs were up regulated after 1 , 25 ( OH ) ( 2 ) D ( 3 ) exposure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The oIFNtau gene promoter / enhancer ( 654 to + 1 bases , wild type ) luciferase reporter construct ( pGL 3 654 ) or its mutant at the AP 1 or Ets 2 site was cotransfected with CBP ( pRc / RSV CBP ) construct along with c jun , c fos , and / or Ets 2 expression plasmid . ^^^ Cotransfection of CBP with c jun and / or Ets 2 , but not with c fos , further increased oIFNtau gene transactivation although amounts of c jun and c fos expression , resulting from expression vectors , were similar . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These events were paralleled by an increase of the activator protein 1 constituents c Fos and c Jun . ^^^ Whereas DNA binding activity of c Jun remained unchanged , DNA binding activity of c Fos was significantly enhanced by resveratrol and piceatannol , but inhibited by EGCG . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The JNK deficient cells exhibited decreased expression of c Jun , JunD , c Fos , Fra 1 , and Fra 2 ; decreased phosphorylation of c Jun and JunD ; and decreased AP 1 DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of selenium and iodine on c fos and c jun mRNA and their protein expressions in cultured rat hippocampus cells . ^^^ The objective of the study was to investigate the effect of selenium ( Se ) and iodine ( 1 ) for expressions of c fos and c jun mRNA and their proteins in cultured rat hippocampus cells in selenium and iodine containing medium . ^^^ The expressions of c fos / c jun in cultured rat hippocampus cells ( 1 d , 3 d , 5 d , 7 d , and 10 d ) were studied by using both in situ hybridization histochemistry and SABC immunohistochemistry techniques . ^^^ Both Se and 1 could enhance expressions of c fos and c jun mRNA and their proteins , especially c jun mRNA expression in the Se and 1 united group . ^^^ Se and 1 could promote the expressions of c fos and c jun and thus may affect the differentiation and development of hippocampus neurons . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 17 induced also HLA class 1 , C Fos , nuclear factor kappa B ( NF kappa B ) and C Jun expression by myoblasts but not that of HLA class 2 , CD 40 , vascular cell adhesion molecule 1 ( VCAM 1 ) and intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CRP also activates the MAPK > c Fos / cJun > AP 1 pathway . ^^^ C reactive protein increased the expression of early response genes , c fos and c jun and inflammatory genes , monocyte chemoattractant peptide ( MCP 1 ) and interleukin 6 ( IL 6 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The complexes formed with labeled AP1 / E box oligonucleotide were reduced or supershifted with antisera to Fos family , c Fos , Fra 2 , and Jun D . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Under conditions where JNK 1 and ERK 2 were activated , BHA also activated transcription factors nuclear factor kappa B ( NF kappaB ) , activated protein 1 ( AP 1 ) , and anti oxidant response element ( ARE ) , leading to induction of genes such as c jun , and c fos . ^^^ Our data , together with the work of others , enable us to propose a model in which low concentrations of these chemicals ( e . g . , BHA , PEITC ) activate MAPKs leading to induction of gene expression ( e . g . , c jun , c fos , GSI ) which may protect the cells against toxic insults and enhance cell survival . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thus , the binding of p202a results in the inhibition of the sequence specific binding to DNA of the c Fos , c Jun , E2F1 , E2F4 , MyoD , myogenin , and c Myc transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two days after MCAO , the brains were removed for immunohistochemical evaluation of caspase 3 , terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) , activated microglia , and the expression of AP 1 proteins ( c Fos and c Jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In hepatocytes , CD 40 ligation led to sustained up regulation of AP 1 activity > 24 h associated with increased protein levels of RelA ( p 65 ) , c Jun , and c Fos , whereas no induction of AP 1 activity was observed in IHECs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phosphorylated JNKs activate the oncoprotein c Jun , which is known to form the activator protein 1 ( AP 1 ) transcription factor as a homo or heterodimer . c Jun ' s principal dimerization partner is c Fos , which participates in the differentiation and function of osteoblasts and in the pathogenesis of osteosarcomas . ^^^ We assessed the protein levels of the two major JNK isoforms ( JNK 1 and JNK 2 ) ; their phosphorylated hence activated species , p JNK ; their substrate , c Jun ; its phosphorylated ( activated ) form , pc Jun ; and c Jun ' s heterodimeric partner , c Fos . ^^^ Positive immunostaining for JNK 1 , JNK 2 , p JNK , c Jun , pc Jun , c Fos , and alpha NAC was observed in 86 , 93 , 94 , 99 , 97 , 99 , and 97 . 5 % of the samples , respectively , whereas normal bone was devoid of these immunoreactivities . ^^^ When cellular levels of the JNK pathway components and c Fos were evaluated as possible biological markers of tumor grade , high expression of c Jun and abundant pc Jun predicted a high grade tumor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Members of the AP 1 family , c Jun and c Fos , functionally interact with JC virus early regulatory protein large T antigen . ^^^ We have recently demonstrated the involvement of the AP 1 family members c Jun and c Fos in transcriptional regulation of the human polyomavirus , JC virus ( JCV ) , genome . ^^^ Transfection and replication studies indicated that c Jun and c Fos can significantly diminish T Ag mediated JCV gene transcription and replication . ^^^ Taken together , these data demonstrate that immediate early inducible transcription factors c Jun and c Fos physically and functionally interact with JCV major early regulatory protein large T Ag and that this interaction modulates JCV transcription and replication in glial cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A peptide fragment of ependymin neurotrophic factor uses protein kinase C and the mitogen activated protein kinase pathway to activate c Jun N terminal kinase and a functional AP 1 containing c Jun and c Fos proteins in mouse NB2a cells . ^^^ The CMX 8933 activated AP 1 specifically bound an AP 1 consensus probe and appeared to contain c Jun and c Fos protein components in antibody supershift experiments . ^^^ Because AP 1 influences a variety of positive and negative cellular processes , determined in part by its exact protein composition and mechanism of activation , we extended these initial AP 1 observations in the current study to confirm the identity of the CMX 8933 activated c Jun and c Fos components . ^^^ These data are in agreement with the recently proposed model for the conversion of short to long term synaptic plasticity and memory , in which a JNK activated transcription factor AP 1 , containing c Jun and c Fos components , functions at the top of a hierarchy of transcription factors known to regulate long term neural plasticity . . ^^^ CMX 8933 increases the enzymatic activity of c Jun N terminal kinase ( JNK ) , increases the phosphorylation of JNK and c Jun proteins , and increases the cellular titers of c Jun and c Fos mRNAs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Early targets of activated ERK , c Jun and c Fos , were elevated during infection , as demonstrated by semiquantitative reverse transcription PCR . ^^^ Immunostaining revealed that the endothelium and the interstitial cells were most intensely stained with antibodies to c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of chlorimethylmercury on the expression of c fos and c jun genes in rat brain ] . ^^^ To study the role of immediate early genes ( IEG ) c fos and c jun in the neurotoxic mechanism of methylmercury chloride ( MMC ) , expression of FOS and JUN in rat brains was observed by using immunohistochemical methods . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression levels of c jun , c fos and p 53 were evaluated by western blotting . ^^^ Both were found to be overexpressed in p 53 and c jun proteins , rather than that of c fos , associations with the resulted apoptosis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 ( c Fos / c Jun ) is required for corneal epithelial spreading . ^^^ PURPOSE : We previously demonstrated that the AP 1 components c fos / c jun are up regulated in healing rat corneal epithelium in a relatively early phase following epithelial dbridement , implicating the AP 1 function in the initiation of cell movement . ^^^ CONCLUSION : AP 1 ( c Fos / c Jun ) is required for the corneal epithelial spreading . . ^^^ AP 1 ( c Fos / c Jun ) is required for corneal epithelial spreading . ^^^ To explore this hypothesis , we examined the effect of lack of c Fos and c Jun protein expressions on the spreading of corneal epithelium and in situ in organ culture . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of AP 1 ( c fos / c jun ) in developing mouse corneal epithelium . ^^^ CONCLUSION : These findings indicate that AP 1 ( c fos / c jun ) transcription factor may play a role in the development and maturation of the corneal epithelium in mice . . ^^^ The mRNAs for c jun were also detected , although the temporal expression patterns differed . c Fos immunoreactive nuclei were present from E14 . 5 through P 10 and c Jun immunoreactive nuclei were detected from E14 . 5 through P 3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of the AP 1 proteins studied , c Jun was expressed at the highest level , followed by JunD , c Fos , and Fra 2 , although different treatments induced slightly different levels of expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we showed that the ERE decoy potently ablated the 17beta estrogen inducible cell proliferation and induced apoptosis of human breast carcinoma cells by functionally affecting expression of c fos gene and AP 1 luciferase gene reporter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore exposure of cells to insulin has resulted in transient phosphorylation of Elk 1 on Ser 383 and sustained elevation of c Jun and c Fos protein . ^^^ This includes activation of the MAPK cascade and subsequent phosphorylation of Elk 1 followed by increased expression of c fos and c jun genes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNA array analysis revealed that expression of genes such as the RhoG and D 4 GDI genes was down regulated in TEL overexpressing cells , while that of the representative growth related genes such as the c myc , c fos and c jun genes was not remarkably changed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : We found that nuclear factor kappaB ( NF kappaB ) , as well as c Fos and c Jun , the components of activator protein 1 ( AP 1 ) , are activated after FcepsilonRI cross linking in human intestinal mast cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assay revealed that the elevated cAMP potentiated AP 1 binding activity by enhancing c fos binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Also , simvastatin reduced NF kappa B and AP 1 dependent reporter gene activity in TNF alpha treated HT 1080 fibrosarcoma cells and reduced the nuclear levels of p 50 NF kappa B , p 65 NF kappa B , and the AP 1 components c fos and c jun in HMC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of microcystins on cell cycle and expressions of c fos and c jun ] . ^^^ OBJECTIVES : To investigate the effects of microcystins on cell cycle and expressions of c fos and c jun , and explore the potential carcinogenic mechanisms of Microcystins . ^^^ Immunohistochemistry assay was applied to detect the expressions of c fos and c jun at 1 , 3 , 6 hr time point , and cell cycle at 6 , 12 , 24 hr point were analyzed by flow cytometry respectively . ^^^ RESULTS : Sustained up regulated expression of c fos and c jun were induced by MCE during the experimental period , and 5 6 folds increased expression were observed at 6 hour point after treatment . ^^^ CONCLUSION : Up regulating the expression of transcript factor such as c fos and c jun thus to induce cell abnormal proliferation may be the potential carcinogenic mechanisms of microcystins . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of intra ischemic hypothermia on the expression of c Fos and c Jun , and DNA binding activity of AP 1 after focal cerebral ischemia in rat brain . ^^^ The aim of this study was to examine the effect of hypothermia on expression of c Fos and c Jun , and AP 1 DNA binding activity , after transient focal cerebral ischemia in rat brain , and clarify the role of IEGs and AP 1 after insults . ^^^ In conclusion , hypothermia decreased cerebral infarction in association with early increases in c Fos expression and AP 1 DNA binding activity in peri infarct cortex . ^^^ Increased c Fos immunoreactivity in the cortex was observed at 3 h after reperfusion in the HT , but not the NT group , while c Jun expression was not affected by HT treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : Compared with RPE65Met ( 450 ) , introduction of the RPE65Leu ( 450 ) variant led to increased levels of RPE 65 protein , accelerated rhodopsin regeneration , loss of protection against light induced damage , and AP 1 responsiveness to toxic light doses , despite the absence of c Fos . c Fos was mainly replaced by Fra 2 . ^^^ Under conditions of high rhodopsin availability during exposure to light , Fra 2 and , to a minor degree , FosB substitute for c Fos and enable light induced AP 1 activity and thus photoreceptor apoptosis . ^^^ Thus , not the absence of c Fos per se , but rather impairment of AP 1 DNA binding is protective against light induced damage . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Three predominant signaling pathways were identified to be inhibited by esculetin : ( a ) the activation of p42 / 44 mitogen activated protein kinase ( MAPK ) and the downstream effectors of c fos and c jun immediate early genes by means of western and reverse transcription polymerase chain reaction ( RT PCR ) analyses ; ( b ) the activation of nuclear factor kappaB ( NF kappaB ) and activator protein 1 ( AP 1 ) , using the electrophoretic mobility shift assay ; and ( c ) the activation of phosphoinositide 3 kinase ( PI 3 kinase ) and cell cycle progression , by western blot analysis and flow cytometric detection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The same PKCepsilon inhibitors blocked S1P evoked increases in T cell nuclear levels of c Fos and phosphorylated c Jun and JunD after 24 h , but not 1 h . ^^^ A mixture of c Fos plus c Jun antisense oligonucleotides prevented late recovery of down regulated CT and CI , without affecting S1P induction of down regulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In these cell lines , stimulus induced increases in c Fos protein levels were dramatically attenuated , while c Jun and CREB levels remained unchanged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : Microarray analysis revealed that the mRNA expression of multiple immune modulators , including krox 24 , interferon gamma regulating factor 1 ( IRF 1 ) , monocyte chemoattractant protein 1 ( MCP 1 ) , interleukin 1beta ( IL 1beta ) , CCAAT / enhancer binding protein ( C / EBP ) , p 21 , c fos , c jun , and pJunB , was significantly increased in obstructed compared to sham operated kidneys ( all P < 0 . 05 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , cycloheximide inhibited the increased c Fos and c Jun protein expression levels induced by KA in the hippocampus . ^^^ Our results suggest that the increased expression of the c Fos , c Jun , and phosphorylation of ERK , JNK 1 , and CaMK 2 proteins may play important roles in the memory impairment and the cell death in CA 3 region of the hippocampus induced by i . c . v . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since activator protein 1 ( AP 1 ) , a heterodimer of c jun and c fos proteins , is known to inhibit binding of AR to ARE by protein protein interaction with AR , the findings in the present study suggest a possible involvement of AP 1 in the antiandrogenic effects of PAHs acting as AhR agonists . ^^^ The antiandrogenic PAHs elevated mRNA levels of c fos and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thus , Pdcd 4 suppresses tumor phenotype by inhibiting AP 1 dependent transcription , possibly through inhibiting c Jun and c Fos activation . . ^^^ In a Gal 4 fusion assay , Pdcd 4 specifically inhibited activation of c Jun and c Fos activation domains , but did not inhibit activation of JunB , JunD , Fra 1 , or Fra 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transformation of REF cells by oncogenes E1A and cHa ras leads to activation of AP 1 factor concomitantly with down regulation of c fos gene transcription . ^^^ To this end , we studied the kinetics of serum stimulated transcription of c fos , c jun , fra 1 , egr 1 , and cyclinD 1 genes , as well as the effects of sodium butyrate , an inhibitor of histone deacetylase activity , on transcription of these genes in normal REF cells and transformants E1A+ras . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In HUVECs exposed to SS , chromatin within c fos and c jun promoters was specifically immunoprecipitated by an antibody against acetylated histone H 3 on K 14 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Northern blot analysis 30 min after growth factor stimulation showed that c FOS and c JUN mRNAs were induced more strongly in neointimal than in medial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The levels of c jun mRNA and c Fos protein and mRNA in selenite injected rats also increased more than in the control . ^^^ These results suggested that selenite induced apoptosis accompanied by the activation of caspase 3 and JNK and the upregulation of c jun , c fos , p 53 and p 21 ( WAF1 / CIP1 ) at the early stage of liver regeneration . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several putative transcriptional factor binding sites for nuclear factor of activated T cells 1 , AP 1 ( c JUN and c FOS ) , AP 2 , GABP , OCT 1 , GATA 3 , PRE , and C ETS 1 were predicted in the promoter region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A nuclear run on assay showed induction of c fos and c jun transcripts at the end of the exposure , peaking at 12 hr after resuspension of cells in drug free medium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression levels of heat shock protein 70 ( HSP 70 ) , c jun and c fos genes were remarkably up regulated and those of c myc and poly ( ADP ribose ) polymerase ( PARP ) were down regulated in bupivacaine treated cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IR was found to enhance the expression of c Jun and , in particular , ATF 3 , but , in contrast to various other stress stimuli , did not induce the expression of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition to shock response genes , such as hsp 70 and hsp 40 , the stress response genes c jun , c fos and egr 1 were expressed in the early phase after heat shock . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Also , GLP 2 produced a significant increase in the mRNAs of c fos and c jun when gene expression was determined by Northern blotting . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , using an in vitro model of ovarian cancer , we demonstrated that malignant transformation of ROSE cells resulted in alteration of downstream effectors of the EGFR pathway , as exemplified by aberrant expression of p66Shc , c Jun , c Myc , c Fos , Lot 1 , p21Cip / Waf , and cdc25A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , it was evaluated whether corticosterone regulation of these genes depends on interactions with the transcription factor complex activator protein 1 . c fos antisense oligodeoxynucleotides were injected into the dorsal hippocampus of adrenalectomized rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oncogenes , such as c myc , c fos , and c jun , are also up regulated in this model . alpha Fetal protein can be detected shortly after implantation and correlates with tumor growth , and measurement of serum alpha fetal protein serves as an early biomarker to monitor the effect of antitumor therapy . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The repressor element bears sequence homology to an activator protein 1 element , constitutively binds c Fos but not c Jun , and is activation independent . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility supershift assay indicated that the JunB , JunD , and c Fos components of AP 1 were particularly affected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CHOP dimerizes with and inhibits the binding of C / EBP related transcription factors to their consensus DNA target sequences and also forms novel complexes with other transcriptional proteins ( e . g . c Jun , c Fos ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using specific polyclonal antisera against c Fos , JunB , c Jun and JunD , we tried to identify the candidate transcription factors of the immediate early gene family which may contribute to the molecular processes during contextual memory reconsolidation . ^^^ In these mice context dependent memory retrieval evoked a marked induction of c Fos and JunB , but not of c Jun and JunD , in pyramidal CA 1 neurons of the dorsal hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both VPA and lithium altered the expression of the early inducible genes for c fos and c jun thus promoting the expression of specific proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These biomarkers included the early injury markers HSP 72 , c jun and c fos which are essential for converting stimuli into intracellular changes within neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two cell lines with different expression profiles of AP 1 were employed focusing on the Fos family members c Fos , Fra 1 and Fra 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In F 28 7 strain , FUdR induced the increased mRNA level of c jun , c fos and c myc genes , caspase 3 like protease activity and the changes of mitochondrial membrane potential which were greater and earlier than those of F 28 7 A strain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although expression of the subunits of NF kappaB ( p 65 , p 50 ) and AP 1 ( c fos , c jun ) did not increase , irradiation caused a rapid and persistent translocation of p 65 and p 50 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results from mobility shift assays and Western blotting analysis revealed that this AP 1 binding increase involved c Jun , but not c Fos . ^^^ This study demonstrates that multiple kinase activities are involved in the mechanism of ox LDL induced AP 1 activation in mesangial cells , and ox LDL stimulates AP 1 through JNK c Jun other than MEK c Fos signalling pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Its target c Jun was selectively phosphorylated in CA 1 , CA 3 and the dentate gyrus and c Fos , the transcription of which is under the positive control of c Jun N terminal kinase target Elk 1 , was selectively up regulated in CA 1 and CA 3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Sheep maxillary bone was distracted daily for 15 days . c Jun and c Fos were evaluated by Northern blotting analysis and immunohistochemistry in biopsy specimens removed at 8 and 15 days and were compared with post osteotomy but not distracted repair tissue . ^^^ Elevated levels of c Jun and c Fos mRNA were found after 8 days of distraction . ^^^ After 15 days of distraction , when bone trabeculae start to form distally and proximally in the distracted regeneration tissue , mostly preosteoblasts and osteoblasts retained c Fos and c Jun immunoreactivity , similar to bone associated cells in control non distracted fracture repair tissue . ^^^ We propose that the elevated expression of c Jun and c Fos is related to mechanical stimulation in this in vivo bone regeneration system . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It shifted the TPA response element binding activator protein 1 composition from c Jun homodimers to c Fos / c Jun heterodimers . ^^^ Histamine induced enhancement of nerve growth factor secretion , promoter activity , activator protein 1 transcriptional activity , and c Fos expression was suppressed by H 1 antagonist pyrilamine , protein kinase C inhibitor calphostin C , and PD 98059 , an inhibitor of mitogen activated protein kinase kinase 1 . ^^^ Histamine transiently induced c Fos mRNA expression , which was not detectable in unstimulated keratinocytes , whereas c Jun mRNA expression was constitutive and was not altered by histamine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the current study , we examined the expression of seven fos / jun family member mRNAs ( c fos , fosB , fos related antigen ( fra ) 1 , fra 2 , junB , c jun , and junD ) and three other IEG mRNAs ( egr 1 , egr 3 , and nur 77 ) in mouse brain following short term ( 6 h ) sleep deprivation ( SD ) and 4 h recovery sleep ( RS ) after SD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of proto oncogenes c fos and c jun in osteoblasts activated by excessive fluoride ] . ^^^ OBJECTIVE : To study expression of proto oncogenes c fos and its accompanying gene c jun in osteoblasts activated by action of excessive fluoride in vivo and in vitro . ^^^ Expression of both mRNA and protein of c fos and c jun in bone tissue of rats with chronic fluorosis and cultured osteoblast like cells were determined by hybridization in situ , Western blot and immunohistochemistry at varied time periods after exposure . ^^^ RESULTS : Sodium fluoride could stimulate the proliferation of osteoblast in rats with chronic fluorosis and induce expression of both c fos and c jun in all envelops of the spine bone , as compared with its control group . ^^^ Value of optical absorption in mRNA expression of c fos and c jun was 139 . 63 and 126 . 37 , respectively , in rats with NaF plus high calcium , significantly lower than that in control group with high calcium only ( 107 . 74 and 117 . 48 , respectively ) ( P < 0 . 001 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the nuclear factor kappaB and proto oncogenes c fos and c jun are induced by low extracellular Mg2+ in aortic and cerebral vascular smooth muscle cells : possible links to hypertension , atherogenesis , and stroke . ^^^ Proto oncogene ( c fos , c jun ) and nuclear factor kappa B ( NF kappaB ) expression , as well as DNA synthesis , in aortic and cerebral vascular smooth muscle cells ( VSMCs ) were upregulated by a decrease in extracellular magnesium ions ( [ Mg2+ ] o ) . ^^^ These data show that [ Mg2+ ] o may be an important , heretofore , overlooked natural modulator of proto oncogene and NF kappaB expression in VSMCs and that Ca2+ and PKC may play critical roles in induction of c fos and c jun in VSMCs induced by a decrease in [ Mg2+ ] o . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using the MEK inhibitor PD 098059 in order to assess the role of ERK MAPK in PMA / Io stimulated splenocytes ( SPLC ) , it was determined that IL 2 production and expression of c fos and c jun nuclear protein expression depended on activation of ERK MAPK . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EMSAs indicated that multiple transcription factors including c Jun and c Fos bound to the activator protein 1 like site and that their DNA binding activity was not significantly affected by E 2 treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Viability was analyzed by a colorimetric assay , islet mass by DNA content , JNK activity by Western blots , AP 1 nuclear activity with a promoter Luciferase AP 1 responsive construct , and c Fos , Jun D , and ATF 2 nuclear activities by an enzyme linked immunosorbent assay . ^^^ The 17beta estradiol induced a significant reduction in nuclear AP 1 , c fos , Jun D , and ATF 2 activities . ^^^ These effects were associated with reduction in JNK targets , including the nuclear activities of transcription factors AP 1 , c Jun , c Fos , Jun D and ATF 2 , involved in apoptosis in beta cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The 6 cDNA probes ( p 16 , c fos , c jun , c myc , p 21 , and p 53 mRNA ) were found to be existing in Beijing Cancer Institute L 1210 and two different cloned cell strains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of proto oncogens c fos and c jun expression in BALB / c 3T3 cells by cadmium chloride ] . ^^^ METHODS : We investigated the alternations in expressions of the proto oncogens c fos and c jun in BALB / c 3T3 cells induced by cadmium chloride ( CdCl 2 ) , using differential RT PCR protocol . ^^^ CONCLUSION : The results seem to indicate that overexpressions of c fos and c jun are related to genotoxicity of CdCl 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis revealed participation of particular Fos / Jun family proteins , such as c Fos , Fos B , c Jun , Jun B , and Jun D , in MT 9 binding in hippocampal mitochondrial extracts prepared 4 hr after kainate treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Suppressive effect of taurine on platelet derived growth factor ( PDGF ) BB induced c fos and c jun mRNA expressions through extracellular signal regulated kinase ( ERK ) in mesenchymal cell lines . ^^^ Taurine inhibited PDGF BB induced c fos and c jun mRNA expressions dose dependently , although structural analogues of taurine did not . ^^^ Thus , the inhibitory mechanism of taurine on PDGF induced c fos and c jun mRNA expressions may depend on the p44 / p42 ERK pathway , but not on PDGF beta receptor tyrosine phosphorylation , JNK / SAPK or p 38 MAPK pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 subunits c Fos , Fos B , Jun B , and Jun D , but not Fra 1 or Fra 2 , were all induced by CpG ODNs in B cells within 30 minutes of stimulation , followed by c Jun at 1 2 hours . c Jun reached maximum at 6 hours . ^^^ AP 1 subunits c Fos , Fos B , Jun B , and Jun D , but not Fra 1 or Fra 2 , were all induced by CpG ODNs in B cells within 30 minutes of stimulation , followed by c Jun at 1 2 hours . c Jun reached maximum at 6 hours . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The 32 globes were immunohistochemically analyzed using anti c Fos and anti c Jun antibodies . ^^^ RESULTS : Immunohistochemistry showed that normal LECs lacked immunoreactivity for c Fos or c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By using the DNA affinity precipitation assay in HaCaT and SL 2 cells , Sp 1 directly interacted with the Sp 1 site of the promoter , and c Jun and c Fos precipitated with the Sp 1 oligonucleotide was attributable to the interaction between the Sp 1 and AP 1 proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of c Jun N terminal kinase and p 38 MAPK by GnRH was unaffected by EGFR or gelatinase inhibition that , however , suppressed GnRH induction of c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , co transfection of c jun and c fos expression vectors resulted in stimulation of reporter gene activity , indicating an involvement of AP 1 transcription factors in PLZF expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phosphorylation of the carboxyl terminal transactivation domain of c Fos by extracellular signal regulated kinase mediates the transcriptional activation of AP 1 and cellular transformation induced by platelet derived growth factor . ^^^ Among them , the AP 1 ( activating protein 1 ) family of transcription factors , including c Fos and c Jun family members , plays a key role , as AP 1 activity is potently activated by PDGF and is required to stimulate cell proliferation . ^^^ In this study , we show that PDGF regulates AP 1 by stimulating the expression and function of c Fos through extracellular signal regulated kinase ( ERK ) . ^^^ Interestingly , the phosphorylation of c Fos by ERK was required for the ability of PDGF and serum to stimulate the activity of c Fos as well as AP 1 dependent transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hypertrophic agonists induce the binding of c Fos to an AP 1 site in cardiac myocytes : implications for the expression of GLUT 1 . ^^^ Hypertrophic stimuli transiently induced AP 1 dimers containing c Fos , and this was dependent on the ERK mitogen activated protein kinase pathway and coincided with the activation of AP 1 mediated transcription and the induction of GLUT 1 in cardiac myocytes . ^^^ CONCLUSION : Our data suggest that induction of c Fos containing AP 1 heterodimers may partly activate AP 1 mediated transcription in cardiac myocytes treated with hypertrophic agonists under conditions known to induce GLUT 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : First , the authors studied the inhibitory effects of intrathecal c Fos antibody electroporation on the activating protein ( AP 1 ) promoter activity in cultured spinal neuronal cells transfected with p AP Luc plasmid and activated with 100 microm glutamate . ^^^ The inhibitory effect of c Fos antibody electroporation in the regulation of AP 1 promoter activity was assessed according to the relative luciferase activity . ^^^ RESULTS : Cotransfection of c Fos antibody significantly decreased glutamate induced AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To further delineate ultraviolet A ( UVA ) signaling pathways in the human keratinocyte cell line HaCaT , we examined the potential role of mitogen activated protein kinases ( MAPKs ) in UVA induced activator protein 1 ( AP 1 ) transactivation and c Fos expression . ^^^ The role of JNK and p 38 MAPK activities in UVA induced signaling pathways leading to AP 1 activation and c Fos expression . ^^^ To examine the role of p 38 and JNK MAPKs in UVA induced AP 1 and c fos transactivations , the selective pharmacologic MAPK inhibitors , SB 202190 ( p 38 inhibitor ) and SP 600125 ( JNK inhibitor ) , were used to independently treat stably transfected HaCaT cells in luciferase reporter assays . ^^^ Both SB 202190 and SP 600125 dose dependently inhibited UVA induced AP 1 and c fos transactivations . ^^^ These results demonstrated that activation of both JNK and p 38 play critical role in UVA mediated AP 1 transactivation and c Fos expression in these human keratinocyte cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Co transfection with c jun and c fos expression plasmids , which encode the two subunits of AP 1 , activated the wild type Nac 1 intron 1 enhancer two fold over basal , nearly at the level of NAC 1 enhancer activity seen in differentiated N2A cells . ^^^ Activation of immediate early genes such as c fos and c jun following chronic drug treatments has been well characterized . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c myc , c fos , c jun , Ha ras , and p 53 mRNAs was determined using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The immediate early gene c fos is part of the activator protein 1 transcription factor and has been postulated to participate in the molecular mechanisms of learning and memory . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Human wee 1 kinase is directly transactivated by and increased in association with c Fos / AP 1 : rheumatoid synovial cells overexpressing these genes go into aberrant mitosis . ^^^ We isolated human wee 1 kinase gene promoter and found that it contained one AP 1 binding motif in its promoter region ( 5 ' CGAGTCA 3 ' ; 823 / 817 ) , through which wee 1 kinase gene was directly transactivated by c Fos / AP 1 . ^^^ In rheumatoid synovial cells , wee 1 kinase was increased in conjunction with the increase of c Fos / AP 1 and the substrate of wee 1 , cdc 2 , was phosphorylated . ^^^ The amount of wee 1 and c Fos and the phosphorylation of cdc 2 were decreased after treatment of the cells with an inhibitor of AP 1 , curcumin . ^^^ Thus , human wee 1 kinase gene is directly transactivated by and increased in association with c Fos / AP 1 , and rheumatoid synovial cells overexpressing these genes go into aberrant mitosis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blot analysis demonstrated decreased expression of transcriptional activators ( pCREB 1 , pATF 1 , USF 1 , c Fos , c Jun , Sp 1 , and Sp 3 ) and / or increased expression of repressors ( short Sp 3 isoforms ) , whereas normal AP2alpha levels were retained . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By employing conditional c Fos expression , we observed that continuous activation of c Fos and consequently AP 1 activity leads to depolarization of differentiated murine epithelial hepatocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of JNK significantly reduced phosphorylation of the specific JNK substrate c Jun ( p < 0 . 05 ) , IL 1beta induced apoptosis ( p < 0 . 001 ) , and IL 1beta mediated c fos gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) binding to DNA increased more in VSMC from old versus young rats ( P < 0 . 02 ) and was related to increased expression of its components , c Fos , Fra 1 , and JunD . ^^^ Activator protein 1 ( AP 1 ) binding to DNA increased more in VSMC from old versus young rats ( P < 0 . 02 ) and was related to increased expression of its components , c Fos , Fra 1 , and JunD . ^^^ PD 98059 , a MEK inhibitor , attenuated AP 1 activation , lowered c Fos and Fra 1 protein levels and reduced cell number and cells positive for proliferating cell nuclear antigen in old . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This is the only functional AP 1 site identified in the proximal 398 bp , since its mutation eliminates FSHbeta induction by c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous studies showed that palytoxin simulates an ERK dependent selective increase in the c Fos content of AP 1 complexes that bind to the promoter of the MMP 13 gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has also been demonstrated that the additional feedback from factor E2F to genes c fos and c jun , which was predicted earlier based on the computer analysis of promoters , plays an important role in the transition of the cell to the S phase . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The precise mechanisms are not known , but involve the up regulation of c fos , which binds to MMP promoters at a proximal activator protein 1 ( AP 1 ) site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A Western blot analysis revealed an overexpression of BCL 2 , c JUN , c FOS , and RAF 1 proteins , which are involved in the antiapoptotic response and in the regulation of cell growth , differentiation , and development . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hexachlorobenzene induced early changes in ornithine decarboxylase and protein tyrosine kinase activities , polyamines and c Myc , c Fos and c Jun proto oncogenes in rat liver . ^^^ In the present study the in vivo effect of HCB treatment on ornithine decarboxylase ( ODC ) and protein tyrosine kinase ( PTK ) activities , free polyamine content , and c Myc , c Fos , and c Jun protein levels in rat liver were investigated . ^^^ HCB ( 1000 mg / kg body weight ) increased hepatic immunodetectable c Myc , c Fos , and c Jun levels after 6 h , and ODC activity and spermine and putrescine content after 18 and 24 h , while maximum stimulation of PTK activity occurred at 12 h . ^^^ The time course of c Myc , c Fos , and c Jun protein levels was different for each proto oncogene . ^^^ They were all elevated at the second day of treatment , while only c Fos and c Jun remained elevated after 10 days of HCB exposure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays ( EMSAs ) showed that the binding activity of the transcription factor AP 1 ( c Fos / c Jun ) to TF promoter was elevated in response to these oxidation products . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Human peripheral blood mononuclear cells were cultured with M CSF / RANK L for 18 days , and we evaluated bone resorption , the expression of the protein and mRNA of the integrins , c jun and c fos in the presence or absence of estradiol . ^^^ Moreover , the mRNAs of c fos and c jun were both diminished by estradiol and raloxifene , particularly in early osteoclasts , but also to a lesser extent in mature cells . ^^^ These findings suggest that the direct inhibitory action of estradiol on bone resorption may affect human osteoclast differentiation through downregulation of c fos and c jun and adhesion through modulation of beta 3 integrin . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Through the use of a dominant negative c Fos mutant , we show that DDT exposure induces the collagenase promoter in an AP 1 dependent manner . ^^^ DDT stimulates an AP 1 complex shift at the DNA to one favoring c Jun / c Fos dimers through both increasing c Jun levels and by post translational activation of c Jun and c Fos in HEK 293 and human endometrial Ishikawa cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Progestin treatment or overexpression hPR did not alter appreciably the content of c jun or c fos in decidual fibroblasts nuclear extracts . ^^^ Antibody to hPR ( hPRa 3 ) , which precipitated hPR also coprecipitated c jun and c fos , whereas CREB was not precipitated by hPRa 3 . ^^^ In summary , this study provides molecular evidence that the CRE / AP1 site and c jun / c fos in decidual fibroblasts mediate the hPR enhanced activation of FN transcription . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Androgen dependent expression of c jun and c fos in human non transformed epithelial prostatic cells : association with cell proliferation . ^^^ OBJECTIVE : To assess the effect of dihydrotestosterone ( DHT ) on the gene expression of C FOS and C JUN and on the proliferation of human non transformed epithelial prostatic ( HNTEP ) cells . ^^^ METHODS : Cell proliferation ( MTT ) and C FOS and C JUN mRNA expression ( RT PCR ) were determined in cells treated with DHT ( 10 ( 8 ) , 10 ( 10 ) , and 10 ( 13 ) M ) or with control medium . ^^^ RESULTS : DHT 10 ( 13 ) M had a significant stimulatory effect on cell proliferation ( p < 0 . 05 ) and C FOS and C JUN gene expression when compared to cells treated with higher concentrations of this hormone ( 10 ( 10 ) and 10 ( 8 ) M ) or with the control group . ^^^ CONCLUSIONS : Our data demonstrate that the increase in C FOS and C JUN expression and cell growth in HNTEP cells is maximal with the lowest DHT concentration ( 10 ( 13 ) M ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These data suggest that c Fos may act as an inducible cofactor for cell specific transcription factors and unravel a novel mechanism for transcriptional regulation by c Fos , independent of the well studied AP 1 pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AM produced a concentration and time dependent increase in c fos and jun B mRNA expression without observable effects on fos B and c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The interaction between Met and HGF / SF triggers a signaling cascade that leads to increased levels of c Jun , c Fos , and Egr 1 proteins , in agreement with data reported on the signaling events evoked by HGF in other cellular types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All samples were read in triplicate ( n = 4 in all cases ) . c Fos , c jun , caspase 3 , c myc , and p 53 expression was determined after TA treatments after 0 , 10 , 20 , 30 , 40 , 50 , 60 , and 90 minutes . ^^^ Caspase 3 was elevated in both ARPE 19 and SVG cells after TA treatment . c Fos and c jun expression was also increased in ARPE 19 cells but not in SVG . ^^^ TA caused the activation of the caspase 3 pathway more readily than the cell protective c fos and c jun pathways in SVG cells , making those cells more vulnerable than the ARPE 19 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The two cell growth and differentiation related proto oncogenes c FOS and c JUN were increased in all treated animals at early stages . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Similarly to that observed for c Fos expression , HPR treatment increased c Jun expression in HPR sensitive but not in HPR resistant cells , suggesting the involvement of the transcription factor activating protein 1 ( AP 1 ) in HPR induced apoptosis . ^^^ Overall , the results indicate that c Fos plays a role in mediating HPR induced growth inhibition and apoptosis in ovarian cancer cells and suggest that c Fos regulates these processes as a member of the AP 1 transcription factor . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , in brains of Elk 1 deficient mice , cortical and hippocampal CA 1 expression of c fos , but not Egr 1 or c Jun , was markedly reduced 4 h following kainate induced seizures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Possible mechanisms to explain these findings were investigated , and it was found that mepacrine had a strikingly different effect on c Jun , as opposed to c Fos activation . ^^^ While mepacrine treatment alone led to increased concentrations of c Jun within the nuclear compartment , c Fos translocation into the nucleus was blocked in synoviocytes treated with mepacrine and stimulated with PMA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
OBJECTIVE : To study the effects of progesterone ( P ) and 18 methyl levonorgestrel ( LNG ) on the expression of P receptors ( PRA and PRB ) , c fos , c jun , and osteocalcin in the human osteosarcoma cell line MG 63 and human normal osteoblasts in order to understand the mechanism of progestin action on the proliferation and differentiation of osteoblasts . ^^^ The expression of PR , c fos , c jun , and osteocalcin was measured by semi quantitative RT PCR , Western immunoblot or immunocytochemistry . ^^^ Progesterone and LNG did not affect the expression of PRA and PRB mRNA and protein , but c fos and c jun mRNA and protein were upregulated in a dose dependent manner . ^^^ CONCLUSION : Progesterone and LNG promote osteocalcin gene transcription by stimulating the expression of c fos and c jun , and result in osteoblast proliferation and differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos but not 5 Fos protein induces programmed cell death of 5 myb transformed monoblasts . c Fos and 5 Fos belong to a group of proteins forming the transcription factor AP 1 that is important for regulation of proliferation , differentiation and programmed cell death in multiple cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The activation of downstream transcription factors , c jun and c fos was also observed in response to UVB irradiation . ^^^ The role of PD 98059 , SB 202190 , genistein , and wortmannin in regulating UVB induced c jun and c fos activation and transcription was also investigated . ^^^ The data suggests the involvement of p42 / 44 , p 38 and JNK MAPK pathway and subsequent induction of c fos and c jun in the signal transduction process leading to the activation of macrophages exposed to UVB . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In situ hybridization was used to evaluate depolarization thresholds for induction of mRNAs encoding the 70 kDa heat shock / stress protein , hsp 72 , as well as several immediate early genes ( c fos , c jun , junB , and junD ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ischemia induced changes were related to expression levels of immediate early genes , c fos and c jun , and to expression levels of different cell type specific transcripts . ^^^ Immediate early genes c fos and c jun were transiently upregulated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Matrix assisted laser desorption / ionization ( MALDI ) mass spectrometry was used to obtain spectra of peptide DNA complexes formed by basic domain ( BD 15 ) of c Fos protein and DNA AP 1 site ( 5 ' TGAGTCA 3 ' ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Those that were markedly up regulated were c fos protooncogene , FBJ osteosarcoma oncogene B , and Jun oncogene ; those markedly down regulated were pleiotrophin , histidine triad nucleotide binding protein , protein kinase C iota , and large multifunctional protease 7 . ^^^ The genes were c fos , FBJ osteosarcoma , Jun , pleiotrophin , a disintegrin like and metalloprotease with TS 1 motif protein 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A relatively small number ( approximately 30 ) of genes changed expression , including several proliferation inducing transcription factors such as c fos and c jun , protein phosphatases , and adhesion molecules , but no genes involved in differentiation to mature T cell stages . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the possible mechanism of electroacupuncture preconditioning ( EAPC ) and combined with ATP sensitive potassium channel ( KATP ) blocker preconditioning for hypoxia / ischemic brain injury protection by observing the changes of the immediate genes ( c fos and c jun protein content ) in brain at the early stage after cerebral hypoxia / ischemic injury , and the effect of EAPC on these changes . ^^^ METHODS : Integrated density ( ID ) of c fos and c jun expression was measured by Western blot and computerized image processing . ^^^ RESULTS : Hypoxia / ischemia could induce c fos and c jun protein in both cerebral cortex and hippocampus simultaneously , with the peak appearing 2 4 hrs later , and the expression in hyppocampus was higher than that in cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PURPOSE : The sex steroid control of the endometrial cycle is mediated by transcription factors , four of which are the estrogen and progesterone receptors , c jun and c fos , all expressed by the endometrium . ^^^ RESULTS : A correlation between estrogen receptor and c jun and c fos expression was observed in stroma and epithelia , and progesterone receptor expression correlated with c jun expression in epithelia . ^^^ C jun and c fos presented greater expression in the proliferative phase than in the secretory phase , in the stroma and in both epithelia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In astrocytes , like in neurones , ischemia induces the expression of immediate early genes : c fos , c jun , fos B , jun B , jun D , Krox 24 , NGFI B and others . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrated previously that c Jun , JunB and c Fos RNA were dysregulated in metastatic melanoma cells compared with normal human melanocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunohistochemistry was performed to structural neuronal proteins ( MAP 2 , neurofilament proteins ) , beta amyloid precursor protein , growth associated protein 43 and to injury response proteins ( poly ( ADP ribose ) polymerase , poly ( ADP ribose ) , c fos , and c jun ) . ^^^ Poly ( ADP ribose ) polymerase , poly ( ADP ribose ) and c fos were up regulated in both infiltrated and non infiltrated cortex , but c jun expression was greater in areas of tumor infiltrated cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Selegiline also attenuated MPP ( + ) induced transcriptional activation of c fos , c jun , GAPDH , and caspase 3 , suggesting that it may provide neuroprotection by preserving mitochondrial membranes , by attenuating molecular markers of apoptosis , by scavenging free radicals , and by regulating immediate early genes involved in neurodegeneration . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electro acupuncture preconditioning abrogates the elevation of c Fos and c Jun expression in neonatal hypoxic ischemic rat brains induced by glibenclamide , an ATP sensitive potassium channel blocker . ^^^ Using Western blot , the expression of c fos protein ( c Fos ) and c jun protein ( c Jun ) induced by glibenclamide , an ATP sensitive potassium ( K ( ATP ) ) channel blocker was examined from cerebral cortical and hippocampal samples in neonatal hypoxic ischemic rats , with or without EA preconditioning . ^^^ Interestingly , low c Fos and c Jun expressions were found both in diazoxide and EA groups , 24 h after HI . ^^^ However , the level of c Fos and c Jun expression in the group administered glibenclamide after EA was significantly lower than in the glibenclamide group ( P < or =0 . 05 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The use of a dominant negative ERK 5 construct caused selective downregulation of c jun expression , whereas inhibition of Src by PP 2 or MEK 1 by PD 98059 caused decreases in c fos , fra 1 and c jun expression in asbestos exposed C 10 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
C fos and c jun , but not c Met , were observed in OFD and in the fibrous and epithelial components of differentiated and classical adamantinomas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We compared the expression of the early genes c fos , c myc , and c jun in six dilated cardiomyopathic hearts ( DCM ) and 15 patients with left ventricular volume overload ( VOL ) resulting from mitral / aortic regurgitation and no significant stenosis or hypertrophic manifestations , using eight healthy donor hearts as controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that Ogt mutation results in the loss of O GlcNAc and causes T cell apoptosis , neuronal tau hyperphosphorylation , and fibroblast growth arrest with altered expression of c Fos , c Jun , c Myc , Sp 1 , and p 27 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , we found enhanced activation of the RAF / MEK / ERK cascade as mRNAs of MKP 1 , c jun , c fos , and egr 1 were significantly increased at relapse . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression levels of c fos , c jun , Bcl 2 , and Bax were examined . ^^^ The addition of BDNF and FGF promoted survival of adult retinal neurons , increased the number of cells positive for neuron specific enzyme ( NSE ) , Thy1 . 1 , c fos , c jun , and Bcl 2 . ^^^ More c fos and c jun positive cells were observed in cell cultures containing medium with RA . ^^^ However , NT 4 and EGF treatment groups showed no significant difference from control groups in that neuron cell survival was low and fewer cells were positive for NSE , Thy1 . 1 , c fos , c jun , and Bcl 2 . ^^^ CONCLUSIONS : BDNF , FGF and RA improve survival of adult human retinal neurons in vitro via a mechanism that may involve c fos , c jun , and Bcl 2 expression , However , EGF and NT 4 do not improve survival of the adult human retinal neurons . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Besides its function in DNA repair , APE serves to maintain several transcription factors in an active reduced state such as c Fos , c Jun , NF kappaB , p 53 and HIF 1alpha , all of which have been shown to play a role in tumorigenesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hepatocyte treatment with ATPgammaS , a nonhydrolyzable ATP analog , recapitulated early signaling events associated with liver regeneration that is , rapid and transient activation of JNK signaling , induction of immediate early genes c fos and c jun , and activator protein 1 ( AP 1 ) DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interleukin 1beta up regulates the expression of thrombopoietin and transcription factors c Jun , c Fos , GATA 1 , and NF E 2 in megakaryocytic cells . ^^^ In this study , we investigated the possible direct effects of IL 1beta on the expression of thrombopoietin ( TPO ) and transcription factors c Jun , c Fos , GATA 1 , and p 45 nuclear factor E 2 ( NF E 2 ) in MK cell lines CHRF and Meg 01 . ^^^ In CHRF cells , mRNA : c Jun [ 3 . 4 fold , peaked at 15 minutes ] , c Fos [ 4 . 2 fold , 15 minutes ] , GATA 1 [ 4 . 0 fold , 60 minutes ] , NF E 2 [ 3 . 2 fold , 120 minutes ] and protein expression : c Jun [ 3 . 0 fold , 30 minutes ] , c Fos [ 1 . 7 fold , 30 minutes ] , GATA 1 [ 11 . 5 fold , 60 minutes ] , NF E 2 [ 12 . 5 fold , 120 minutes ] were evidently enhanced after treatment with IL 1beta . ^^^ We conclude that IL 1beta up regulates the expression of TPO , c Jun , c Fos , GATA 1 , and NF E 2 in MK cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that dexamethasone ( Dex ) effectively suppressed T cell receptor induced ( TCR induced ) proliferation of naive CD4+ T cells , through a mechanism involving downregulation of c Fos expression and inhibition of activator protein 1 ( AP 1 ) , nuclear factor of activated T cells ( NF AT ) , and NF kappaB transcriptional activity . ^^^ However , enhancement of TCR signaling by CD 28 or IL 2 mediated costimulation abrogated the suppressive effect of Dex on c Fos expression and AP 1 function and restored cellular proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Functional classification of the 25 genes demonstrated alterations of expression of several kinds of biological pathways , regulating transcription ( Bhlhb 2 , Jun , c fos , Egr 1 , Egr 2 , Fosb , Junb , Ifrd 1 , Neurod 6 ) , the cell cycle ( c fos , Fosb , Jun , Junb , Dusp 1 ) , stress response ( Dusp 1 , Dnajb 1 , Dnaja 4 ) , chaperone activity ( Dnajb 1 , Dnaja 4 ) and cell death ( Ptgs 2 , Gadd45g , Tdag 51 ) , in the mouse hippocampus by 24 h of reperfusion . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c jun and c fos was determined by the combination of immunocytochemistry and image analysis software . ^^^ Taurine markedly increased the synthesis of cAMP and suppressed the gene expression of c jun and c fos ( P < 0 . 01 ) in addition to the inhibition of the proliferative effect of platelet derived growth factor BB on HSC . ^^^ This effect on HSC proliferation is associated with the enhancement of the synthesis of cAMP and inhibition of the gene expression of c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blot analysis revealed that phosphorylation of c Jun , a component of AP 1 , occurred in the infected cells , and an analysis of c Fos binding to an oligonucleotide containing an AP 1 consensus site also demonstrated AP 1 activation in infected osteoblasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oxidants cause activation of the AP 1 transcription factor in cardiomyocytes . c Fos , a component of the AP 1 transcription factor , is transiently induced by H2O2 and the induction is sensitive to the protein synthesis inhibitor cycloheximide . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These changes support the increased availability of c Jun / c Fos AP 1 complexes for mediating transcription at the tissue factor promoter . ^^^ Thrombin and tumor necrosis factor alpha synergistically stimulate tissue factor expression in human endothelial cells : regulation through c Fos and c Jun . ^^^ This was due to altered regulation of the transcription factors c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because the diverse biological actions of GnRHa and TGF beta are mediated in part through the MAPK pathway , we determined whether utilization of MAPK / ERK and transcriptional activation of immediate early genes c fos and c jun result in differential regulation of fibronectin , known as key regulator of embryo implantation and endometriosis progression . ^^^ TGF beta 1 and GnRHa increased ERK1 / 2 nuclear accumulation and inversely regulated the expression of c fos and c jun and that of fibronectin in a cell specific manner . ^^^ Pretreatment with U 0126 , a MEK1 / 2 inhibitor , blocked basal , as well as GnRHa and TGF beta 1 induced pERK1 / 2 ; however , it differentially affected c fos , c jun , and fibronectin expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Binding of NF kappaB p 50 , c Rel , p 65 , Sp 1 , Sp 3 , c Fos , and c Jun proteins to their cognate nuclear factor binding sites was somewhat impaired by HV infection , although a role for other as yet unidentified factors can not be dismissed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine the role of AP 1 transcription factors in the development of rat oviduct , we performed immunohistochemistry for epithelial c jun and c fos proteins in E 2 untreated and treated newborn rats . ^^^ Epithelial c jun and c fos are temporally and spatially regulated by estradiol during neonatal rat oviduct differentiation . ^^^ E 2 increased the expression of c jun and c fos during proliferation of undifferentiated epithelial cells , but diminished both proteins during accelerated differentiation of ciliated epithelial cells . ^^^ This study shows that c jun and c fos are regulated during epithelial cell proliferation and differentiation in a region specific manner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We carried out immunohistochemistry in embryonic eye specific antibodies in the mouse to determine the spatial / temporal expression pattern of c Fos and c Jun proteins the main components of the AP 1 transcription factor , in lens epithelial cells during mouse lens morphogenesis . c Fos protein expression was detected in the equatorial epithelium at E14 . 5 P 25 , with a peak at P 1 P8 . c Jun protein expression was detected in equatorial lens epithelial cells at E18 . 5 P 8 , with a peak at P 1 . ^^^ Expression of c Fos and c Jun in developing mouse lens . ^^^ During these intervals , the anterior epithelium lacked expression of c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Earlier we have reported on the transcriptional regulation of DMP 1 by c Fos and c Jun ( AP 1 ) transcription factors . ^^^ Results from earlier study indicate that c Fos and c Jun play an important role in early osteoblast differentiation , whereas they do not have a significant effect on the terminally differentiated osteoblasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , the level of MIP 1alpha , c jun , and c fos genes was not changed by the presence of PTIO in U 937 cells and was even reduced in Mono Mac 6 cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PRL activation of these pathways leads to increased c Jun protein and phosphorylation , JunB protein , and phosphorylation of c Fos , elevating the levels of AP 1 complexes able to bind DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The role of the AP 1 transcription factors c Fos , FosB , Fra 1 and Fra 2 in the invasion process of mammary carcinomas . ^^^ Members of the Fos family of AP 1 transcription factors ( c Fos , FosB , FosB 2 , Fra 1 and Fra 2 ) are able to form dimers with Jun proteins which bind to the regulatory sequences of target genes . ^^^ Results of cotransfection with a MMP 9 promoter construct and AP 1 expression vectors do not indicate a direct up regulation of MMP 9 expression by Fos proteins except a positive effect of c Fos in MCF 7 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cyclic adenosine 5 ' monophosphate response element modulator is responsible for the decreased expression of c fos and activator protein 1 binding in T cells from patients with systemic lupus erythematosus . ^^^ Decreased levels of c fos protein result in decreased AP 1 activity , as determined in shift assays . ^^^ Blockade of the translation of CREM mRNA with an antisense CREM vector increases the expression of c fos and the AP 1 activity . ^^^ We conclude that CREM represses the expression of c fos and limits the activity of the enhancer AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 specific DNA protein binding activity was increased by TNF alpha , and the supershift assay identified the components of c fos and c jun . ^^^ The inhibitory effects of apigenin and luteolin on ICAM 1 expression are mediated by the sequential attenuation of the three MAPKs activities , the c fos and c jun mRNA expressions , and the AP 1 transcriptional activity . ^^^ AP 1 specific DNA protein binding activity was increased by TNF alpha , and the supershift assay identified the components of c fos and c jun . ^^^ Extracellular signal regulated kinase ( ERK ) and p 38 were involved in the c fos mRNA expression , and c Jun NH ( 2 ) terminal kinase ( JNK ) was involved in the c jun mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present communication , we report that human Bcl 2 can positively regulate expression of the proto oncogenes c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of EGCG , a major component of green tea , on the expression of Ets 1 , c Fos , and c Jun during angiogenesis in vitro . ^^^ In this study , we used rat aortic endothelial cells and human umbilical vein endothelial cells growing in collagen gel as a model system to study the tea catechin , ( ) epigallocatechin ( EGCG ) , on the differential expression of transcription factors , Ets 1 , c Fos , and c Jun during endothelial morphogenesis in vitro . ^^^ Immunohistochemistry and immunofluorescence microscopy showed that the reaction products of Ets 1 , c Fos , and c Jun presented predominantly in the nucleus . ^^^ Western blotting showed that the levels of Ets 1 , c Fos , and c Jun reached the highest levels at 12 24 h , decreasing to the basal level at 48 h . ^^^ These results indicated that the morphogenesis of endothelial cells in collagen gel was inhibited by EGCG through the down regulation of Ets 1 , c Fos , and c Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Subsequently , curcumin inhibits the activation of NF ( nucleor factor ) kappaB and the expressions of oncogenes including c jun , c fos , c myc , NIK , MAPKs , ERK , ELK , PI3K , Akt , CDKs and iNOS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In analogous fashion , DON upregulated expression of the chemokines macrophage inhibitory protein 2 ( MIP 2 ) , cytokine induced chemoattractant protein 1 ( CINC 1 ) , monocyte chemoattractant protein ( MCP ) 1 , MCP 3 , and cytokine responsive gene 2 ( CRG 2 ) . c Fos , Fra , c Jun , and JunB , components of the activator protein 1 ( AP 1 ) transcription factor complex , were induced by DON as well as another transcription factor , NR4A1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential expression of AP 1 transcription factor genes c fos and c jun in the helminth parasites Taenia crassiceps and Taenia solium . ^^^ RT PCR amplification of the parasite ' s total RNA , showed that T . crassiceps expressed both AP 1 complex genes , while T . solium only expressed c fos . ^^^ Homologues of c fos and c jun from total DNA of Taenia crassiceps and Taenia solium were cloned and sequenced . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , experiments revealed that the protein and mRNA expression of the AP 1 subunits c Fos , Fra 1 and c Jun was reduced in lesional psoriatic skin compared with nonlesional psoriatic skin , whereas the protein and mRNA expression of the subunit JunB was increased . ^^^ Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP 1 DNA binding activity , and an increase in the protein and mRNA expression of c Fos , Fra 1 and c Jun , together with a decrease in JunB protein and mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cell line studies demonstrate that c Jun and c Fos , via formation of the transcription factor activated protein 1 ( AP 1 ) , activate androgen regulated genes independent of androgens and that c Jun alone acts as an androgen receptor co factor . ^^^ The role of c Jun and c Fos expression in androgen independent prostate cancer . ^^^ Tumour c Jun , activated c Jun , c Fos , and pan protein kinase C ( PKC ) protein expression were analysed by immunohistochemistry and protein expression was scored by two independent observers using a weighted histoscore . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this review , we summarise what is known about the expression and activation of G proteins , JNKs , c Jun and c Fos under oxidative stress conditions within the mammalian cochlea . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Given the evidence for abnormalities in schizophrenia in a neural circuit involving the cerebellum and thalamus , the present study was conducted to examine the expression of MAP kinases extracellular signal regulated kinase ( ERK ) , c Jun N terminal kinase ( JNK ) and p 38 , as well as immediate early genes fos ( c fos and fos B ) and jun ( c jun , jun B and jun D ) using a Western blot analysis and reverse transcription polymerase chain reaction ( RT PCR ) in postmortem thalamus from schizophrenic and control subjects . ^^^ There were significant increase in ERK 2 , c fos and c jun protein and mRNA levels in thalamus of patients with schizophrenia relative to controls . ^^^ These results taken together with our previous findings provide new evidence for selective abnormalities of distinct MAP kinases and immediate early genes c fos and c jun in a circuit involving the thalamus and cerebellum , which may contribute significantly to the pathophysiology of schizophrenia . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the activation of the signaling pathways involving protein kinase C ( PKC ) and the subsequent steps involving mitogen activated protein kinase ( MAPK ) and c fos and c jun oncogenes are known to be important mechanisms implicated in cellular growth , we investigated how the blockade of tumoral GHRH receptor splice variants and BN / GRP receptors by these antagonists could interfere with these intracellular signaling pathways . ^^^ In addition , expression of c fos and c jun mRNA was reduced after combined treatment with JV 1 65 and RC 3940 2 . ^^^ These findings suggest that the anti proliferative effects of antagonists of GHRH and BN / GRP on H 69 SCLC involve an inhibition of the signaling pathways of specific PKC isoforms , MAPK and c fos and c jun oncogenes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hydrogen peroxide treatment enhanced the accumulation of hsp 90 , hsp 70 , hsp 30 , c jun , c fos , and actin mRNAs with distinct temporal patterns . ^^^ Although hsp 70 , c fos , and c jun mRNA levels peaked at 1 2 h before declining , hsp 30 and hsp 90 mRNA levels were maximal at 4 6 h . ^^^ Treatment of kidney cells with a combination of mild heat shock plus hydrogen peroxide resulted in a synergistic increase in the relative levels of both hsp 70 and hsp 30 mRNA , but not hsp 90 , c fos , c jun , or actin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Developmentally regulated expression of c Fos and c Jun in the brainstem auditory nuclei of Gallus domesticus is modified by prenatal auditory enrichment . ^^^ To understand the cellular mechanism of response to prenatal auditory stimulation , we studied the expression of c Fos and c Jun in brainstem auditory nuclei , nucleus magnocellularis , and nucleus laminaris of the domestic chick . ^^^ In controls , c Fos and c Jun expression in both the nuclei was developmentally up regulated . ^^^ Reduced c Fos expression and increase in c Jun was temporarily observed between E 12 16 . ^^^ In the stimulated groups , c Fos expression was elevated while c Jun showed a reduction matched to controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After the hindpaw injection of formalin in mice , we measured changes in expression of immediate early genes including c fos , c jun , jun B , nerve growth factor induced genes ( NGFI A and NGFI B ) and activity related cytoskeletal protein ( ARC ) using real time PCR . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The significance of activating proteins ( AP 1 ) , c fos , c jun and jun B relative to the AP 1 responsive metallothionein , collagenase and stromelysin gene expression in the pathophysiology of osteoarthritis ( OA ) was investigated . ^^^ The ' early ' c fos , c jun and jun B mRNAs were ubiquitously expressed in normal and OA human knee synovial membranes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RA treatment also induced c fos mediated AP 1 binding , and cAMP responsive element binding protein ( CREB ) mediated CRE binding via ERK1 / 2 and PKA pathway , respectively , in the Cdk 5 promoter region , resulting in the induction of Cdk 5 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two ER subtypes , ERalpha and ERbeta , activate the Activator Protein 1 ( AP 1 ) response elements , and through interactions between ERs and the AP 1 transcription factors c fos and c jun , these transcription factors regulate the genes involved in many cellular processes , including proliferation , differentiation , cell motility , and apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of MAP kinase cascades by arsenic and subsequent regulation of genes including c fos , c jun , and the matrix degrading proteases may play an important role in arsenic induced skin carcinogenesis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ritonavir induced HO 1 protein was suppressed by SB 203580 or SB 202190 and preceded by immediate upregulation of cellular c Fos and c Jun protein levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Quantitative RT PCR revealed that warm ischemia significantly induced up regulation of immediate early genes , c fos , Egr 1 , and c jun , in lung , but not in liver . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Constitutive expression of the AP 1 transcription factors c jun , junD , junB , and c fos and the marginal zone B cell transcription factor Notch 2 in splenic marginal zone lymphoma . ^^^ The AP 1 transcription factors c jun , junD , junB , and c fos as well as Notch 2 were found to be specifically up regulated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AR also strongly and quickly stimulated Akt and ERK phosphorylation and c fos and c jun expression in an EGF receptor dependent manner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^ Results indicate that though AP 1 showed high binding activity and the majority of its members were highly expressed in tumor tissues , there is a distinct pattern of gradual increase of c fos and a concomitant decrease of fra 1 expression that perfectly match the progression of cervical lesions . ^^^ Interestingly , despite very low or absent AP 1 binding in normal as well as in premalignant lesions , AP 1 transcription and its binding activity was found to be very high in malignant tissues showing a preferential heterodimerization of c fos with JunB instead of its canonical dimerization partner c jun . ^^^ Both in vivo and in vitro studies demonstrate that the overexpression of c fos and downregulation of fra 1 expression as well as a change in the dimerization pattern of the AP 1 complex seem to play a crucial role during progression to malignancy . ^^^ Observation of curcumin mediated complete downregulation of AP 1 binding activity and reversal of c fos / fra 1 transcription to a normal state in tumorigenic HeLa cells represents a novel mechanism that can control transcription of pathogenic HPVs during keratinocyte differentiation and progression of cervical cancer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The immediate early gene c fos is part of the AP 1 transcription factor complex , which is involved in molecular mechanisms underlying learning and memory . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression levels of activator protein 1 family members ( c jun , junB , junD , and c fos ) and transforming growth factor ( TGF ) alpha were significantly lower in TPA treated Smad 3 ( / ) skin , cultured keratinocytes , and papillomas , as compared with Smad 3 ( + / + ) controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
COBRA 1 physically interacted with the AP 1 family members , c Jun and c Fos , and the middle region of COBRA 1 bound to c Fos . ^^^ Lack of c Fos binding site in the COBRA 1 completely abolished the COBRA 1 inhibition of AP 1 trans activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because GnRH and TGF beta receptor signaling is in part mediated through the MAPK pathway , we determined whether the contribution of MAPK / ERK and transcriptional activation of c fos and c jun , result in differential regulation of type 1 collagen , fibronectin , and plasminogen activator inhibitor 1 ( PAI 1 ) gene expression , whose products are known to influence extracellular matrix turnover , which is critical in leiomyoma growth and GnRHa induced regression . ^^^ GnRHa and TGF beta increased ERK1 / 2 nuclear accumulation resulting in differential regulation of c fos and c jun mRNA expression via downstream signaling from MAPK kinase ( MEK ) 1 / 2 , because pretreatment with U 0126 , a synthetic inhibitor of MEK1 / 2 , abolished basal and GnRHa and TGF beta induced pERK1 / 2 and the expression of c fos and c jun . ^^^ We concluded that GnRHa and TGF beta acting through a MAPK / ERK pathway and transcriptional activation of c fos / c jun results in differential regulation of specific genes whose products may in part influence the outcome of leiomyoma growth and regression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , the NO induced apoptosis was associated with increase in caspase 3 activity and in the protein levels of caspase 3 , c Fos , and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of c Fos prior to TH , in conjunction with the upregulation of pCREB and CBP in the LC , suggests that activator protein 1 and CRE transcription sites in the TH gene may be involved in the cell type specific activation in the stress response , at least , by pERK1 / 2 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ionizing radiation induces alterations in cellular proliferation and c myc , c jun and c fos protein expression in breast epithelial cells . ^^^ Expression of the nuclear proto oncogenes , c myc , c jun and c fos , are indicative of early response events during cellular proliferation . ^^^ In contrast , in BP 1 E tumorigenic cell line radiation increased the expression in 68 80 % of c myc , c jun and c fos protein expression relative to non irradiated control . ^^^ Furthermore , radiation increased c my , c jun and c fos protein expression in the c Ha ras 3 Gy cell line relative to non irradiated control cell line ( ranging from 45 and 120 % ) . ^^^ Interesting , among the tumorigenic MCF 10F cells previously exposed to both BP and c Ha ras ( BP 1 Tras 3 Gy cell line ) , radiation increased the c myc , c jun , c fos protein expression by more than 120 % relative to the non irradiated controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Conversely , stable ectopic expression of Net in malignant cells negatively regulated endogenous c fos , resulting in a disappearance of the c Fos protein from the AP 1 transcription complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of trypan blue on the expression of apoptosis related and cell cycle arrest gene expressions including c fos , c jun , p 53 , and p 21 were performed using reverse transcription polymerase chain reaction and immunostaining . ^^^ No significant change in the expression of c fos and c jun was found with all three concentrations of trypan blue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
KA increased immunoreactivities ( IRs ) of phorylated extracellular signal regulated kinase ( p ERK ; at 30 min ) , p CaMK 2 ( at 30 min ) , c Fos ( at 2 h ) , c Jun ( at 2 h ) , glial fibrillary acidic protein ( GFAP at 1 day ) , and the complement receptor type 3 ( OX 42 ; at 1 day ) in hippocampal area . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
UV irradiation increased mRNA and protein expression of the AP 1 family members , c Jun and c Fos , which bound to the AP 1 element in the Smad 7 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of this study was to ascertain the proliferative and probably reparative potentials of the periarticular osteophytes by evaluating the sites of expression of c myc , c jun and c fos oncogenes in this neoplastic repair tissue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Most prominently , c Fos , a component of AP 1 transcription factor , was synergistically induced by SDF 1 / CXCL12 plus other cytokines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of alpha CaMKII decreases the expression of c fos , AP 1 transactivation , and AP 1 DNA binding activity . ^^^ Inhibition of alpha CaMKII results in a decrease in c fos expression and AP 1 activation , leading to inhibition of osteoblast differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
HTLV 1 encoded Tax elevates AP 1 activity through the induction of AP 1 family member gene expression , including c Jun , JunD , c Fos , and Fra 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift EMSA identified c Jun , Fra 2 , and c Fos in AP 1 binding complexes in IE 1 transfected NIH 3T3 cells . ^^^ Ectopic expression of c Jun plus Fra 2 , but not c Fos , induced relB promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cerebral hypoxia and / or ischaemia also produce hyperexpression of specific genes ( c fos , c jun ) which may be involved , in vulnerable districts , in the mechanisms of excitotoxic neuronal death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In human fibroblasts ( HFFF 2 ) , cDNA array , RT PCR and Western blotting studies demonstrated that tryptase , but not 15d PGJ 2 , up regulates c jun , c fos and COX 2 expression , and phosphorylates the extracellular signal regulated kinase isoforms 1 and 2 ( erk1 / 2 ) . ^^^ Furthermore , tryptase effects on erk1 / 2 , c jun , c fos , COX 2 and cell proliferation were prevented by PD 98059 , an inhibitor of the mitogen activated protein kinase kinase ( MEK ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EGF stimulation is mediated by increased synthesis of c fos and c jun , resulting in AP 1 binding to the proximal hPRL pituitary promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our results revealed that pretreatment with ISO significantly inhibited Ang 2 mediated NF kappaB through affecting the degradation and phosphorylation of IkappaBalpha and the activity of IKKbeta and AP 1 activation by influencing the expression of c Fos and c Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report here that c Fos and Fos related antigen 1 ( Fra 1 ) , two inducible components of AP 1 , are recruited to the endogenous interleukin ( IL ) 8 promoter in an IL 1 dependent manner . c Fos activates IL 8 transcription and synergizes in this effect with p 65 NF kappaB . ^^^ Relative to c Fos , the delayed recruitment of Fra 1 to the IL 8 promoter provides an example how AP 1 subunits may dampen excessive chemokine synthesis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CD 14 and toll like receptor 4 dependent regulation of c Fos , c Jun and c Jun phosphorylation in the adrenal gland after burn injury . ^^^ The regulation of c Fos , c Jun , and c Jun phosphorylation in the adrenal gland after burn injury was investigated in this study . ^^^ METHODS : Adrenal glands harvested after an 18 % total body surface area burn were subjected to RT PCR and Western blot analyses of c Jun and c Fos . ^^^ RESULTS : There was a rapid induction of c Jun and c Fos expression ( mRNA and protein ) , and c Jun serine phosphorylation . ^^^ CONCLUSIONS : These data suggest that c Fos and c Jun are activated in the adrenal gland in response to burn injury . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In RAW 264 . 7 macrophages , ricin induced the activation of ERK , JNK , and p 38 MAPK , the accumulation of mRNA encoding tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 1 , the transcription factors c Fos , c Jun , and EGR 1 , and the appearance of TNF alpha protein in the culture medium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While TPA induced activation of nuclear factor ( kappa ) B remained unaffected by both extracts , they inhibited TPA induced activation of activator protein 1 ( AP 1 ) and attenuated the expression of its key component c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This was concurrent with increased transcription of immediate early genes linked to differentiation such as cdk 5 and NeuroD 6 , and activity of AP 1 transcription family members such as c fos , fos B , and jun D . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Three MAPKs , extracellular signal regulated kinase ( ERK ) , p 38 MAPK and c Jun N terminal kinase ( JNK ) , which were simultaneously activated by IL 1beta , mediated subsequent c fos and c jun mRNA expression and DNA binding of AP 1 at different magnitudes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In psoriatic epidermis , c Jun expression was prominent in both hyperproliferating basal and suprabasal keratinocytes , whereas c Fos expression was unchanged . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neither cellular changes in isozymes of PKC nor translocation of these isozymes from cytosol to cell membrane were seen in 278E treated HL 60 cells . 278E caused a downregulation of c myc as well as an up regulation of c fms , c jun and c fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of ATP sensitive potassium channels prevents the cleavage of cytosolic mu calpain and abrogates the elevation of nuclear c Fos and c Jun expressions after hypoxic ischemia in neonatal rat brain . ^^^ The purpose of this study was to determine whether activation of ATP sensitive K+ ( KATP ) channels with diazoxide ( DIZ ) is able to prevent the cleavage of cytosolic mu calpain and abrogate the elevation of nuclear c Fos and c Jun protein ( c Fos , c Jun ) expressions after hypoxic ischemia ( HI ) in brain . ^^^ Western blot and computer image processing were used to detect the integrated density of nuclear c Fos and c Jun at 4 h and cleavage of cytosolic mu calpain at 24 h after HI insults from cerebral cortical and hippocampal samples . ^^^ These data suggests that activation of KATP channels by DIZ reduces the degree of mu calpain proteolysis , and c Fos and c Jun expressions in immature brain may contribute to the neuroprotection of K ( ATP ) channel openers against HIBI . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EPO increased myocyte ( 1 ) nuclear translocation of AP 1 ( c fos / c jun ) , ( 2 ) eNOS , but not iNOS , protein expression , and ( 3 ) NO production . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The eTag technology was used to simultaneously measure the level of expression of four mRNAs c fos , c jun , c myc , and gapdh in NGF treated PC 12 cells in a standard 96 well format . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Deoxynivalenol was found to readily induce expression of cytokines ( IL 1alpha , IL 1beta , and IL 6 and IL 11 ) , chemokines ( MCP 1 , MCP 3 , CINC 1 and MIP 2 ) , components of the activator protein 1 ( AP 1 ) transcription factor complex ( c Fos , Fra 2 , c Jun and JunB ) , as well as two hydrolases ( MKP 1 , CnAbeta ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There was a 2 . 5 + / 0 . 35 fold increase in maximal PTH stimulation of c jun mRNA and smaller but significant increases in c fos accompanied by increased basal and PTH stimulated AP 1 binding in cells expressing increased G ( 11 ) alpha . ^^^ This leads to increased PTH stimulation of MMP 13 expression by increased stimulation of AP 1 factors c jun and c fos . . ^^^ The increase in PTH stimulation of c jun , c fos , and MMP 13 in G ( 11 ) alpha transfected cells were all blocked by bisindolylmaleimide 1 , a selective inhibitor of PKC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The complexes formed were competed out by preincubation with the cold consensus AP 1 binding site , and the DNA binding complex formed on the site contained c Jun and c Fos , which are components of AP 1 transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 DNA binding activity consists primarily of JunD , c Fos , and Fra 1 , and is accompanied with the increased expression and phosphorylation of these subunits . ^^^ The importance of AP 1 as a mediator ERK signaling during differentiation is demonstrated by the findings that expression of c fos siRNA and dominant negative AP 1 / c Jun ( bZIP ) downregulate the TPA and ERK induced expression of alpha2beta1 integrin mRNAs and proteins . ^^^ While inhibition of JNK mainly prevents expression and phosphorylation of JunD and c Jun , inhibition of the ERK pathway suppresses both phosphorylation and expression of Jun proteins , and expression of c Fos and Fra 1 . ^^^ Conversely , coexpression of JunD or c Jun and c Fos can induce alpha2beta1 integrin expression independently of upstream signals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This phosphorylation is transduced into changes in its transcriptional ability as p 38 activated c Fos enhances AP 1 driven gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Brain , pituitary gland , and adrenal gland were obtained to determine the mRNA levels for corticotropin releasing hormone ( CRH ) , CRH receptor 1 ( CRHR 1 ) , pro opiomelanocortin ( POMC ) , ACTH receptor ( MC2R ) , c jun and c fos . ^^^ It was found that maternal deprivation caused significantly higher transcript levels of c fos and CRH in brain accompanied by a down regulation of CRHR 1 mRNA and an up regulation of c jun in the pituitary gland . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of apoptosis related genes ( c fos and c jun ) and cytokines ( TNF alpha and IL 1beta ) mRNAs markedly increased before the development of apoptosis . ^^^ These findings indicate that c fos and c jun oncogenes and TNF alpha and IL 1beta play an important role in the development of T 2 toxin induced apoptosis in keratinocytes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MPTP induced increase in c Fos and c Jun like immunoreactivity in the monkey cerebellum . ^^^ The transcription factors c Fos and c Jun have been described to be overexpressed following many pathological stimuli , but whether they are required for neurodegeneration or neuroprotection is still open . ^^^ In the present report , we analyzed the role of c Fos and c Jun proteins in Purkinje cell degeneration caused by the neurotoxin MPTP ( 1 methyl 4 phenyl 1 , 2 , 3 , 6 tetrahydropyridine ) in the monkey cerebellum , and determined the neuroprotective effect of the antioxidant drug a dihydroergocryptine ( DHEC ) , whose prior and simultaneous administration reduced the MPTP induced neuronal loss in the substantia nigra . ^^^ Immunocytochemistry for c Fos and c Jun like proteins showed persistent increased staining in Purkinje cells of MPTP treated monkeys . ^^^ The results suggest that , at least as far as the cerebellum is concerned , the increase in c Fos and c Jun expression correlate with cell damage , rather than with preservation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In an electrophoretic mobility shift assay , shear stress stimulated nuclear protein binding to the AP 1 binding site , which was supershifted by antibodies to c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we found that MX 1 , a human breast cancer cell line lacking estrogen receptors , exhibited higher AP 1 activity and expressed higher levels of c Jun , c Fos , and Fra 1 when compared with conventional estrogen receptor positive human breast cancer cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Selected genes for cytokines ( interleukin ( IL ) 1 beta and IL 6 ) , chemokines ( RANTES ) , and immediate early genes ( Jun B , c Fos , and c Jun ) were also studied by real time polymerase chain reaction ( PCR ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription of c fos gene and DNA binding activity of transcription factor AP 1 increase upon differentiation of mouse F 9 teratocarcinoma cells ] . ^^^ These complexes contain c Fos / c Jun with Col AP 1 site and c Jun / ATF 2 with Jun 2 AP 1 site as revealed by supershift analysis . ^^^ DNA binding activity of AP 1 transcription factor correlates with increased expression of c fos and c jun genes . ^^^ RT PCR analysis showed an increase in steady state level of c fos and c jun gene transcription at the stage of parietal endoderm ( terminally differentiated F 9 cells ) . ^^^ Transcription of immediate early c fos and c jun genes and DNA binding activity of c Fos / c Jun complex are serum dependent . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
E 2 or E 2 BSA enhanced DNA binding and transcriptional activity of AP 1 and generated c Fos / c Jun heterodimers by inducing c Fos expression . ^^^ Antisense oligonucleotides against c Fos , c Jun , and Sp 1 blocked E 2 or E 2 BSA induced HB EGF transactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jejunum was harvested for nuclear factor ( NF ) kappaB and activator protein 1 ( AP 1 ) measured by electrophoretic mobility shift assay and c jun and c fos ( AP 1 family ) by supershift . ^^^ Arginine and glutamine had no differential effect on NF kappaB , whereas AP 1 expression ( c jun but not c fos ) was markedly enhanced by arginine and significantly lessened by glutamine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of cytokine signaling 3 suppressors gene on c fos and c jun mRNA expression and proliferation of pulmonary arterial smooth muscle cells in rat under hypoxia ] . ^^^ OBJECTIVE : To explore the effects of suppressors of cytokine signaling ( SOCS ) 3 gene on expression of c fos , c jun mRNA and proliferation of rat pulmonary arterial smooth muscle cells ( PASMCs ) under hypoxia . ^^^ After PASMCs were exposed to normoxic and hypoxia at various time points respectively , expression of c fos and c jun mRNA was assessed by semi quantitive RT PCR . ^^^ CONCLUSION : Hypoxia induced expression of c fos and c jun genes , which might play an vital role in the early stage of PASMCs proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results indicated that c Jun N terminal phosphorylation was not required for EGF induced expression of COX 2 . c Jun , which could recruit other transcription factors such as c Fos , was required for EGF induced expression of COX 2 in A 431 cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hydroxyurea induced c Fos heterodimer activity in the embryo peaked 3 4 fold above control at 3 h and remained elevated by 6 h ; in contrast , the activity of c Jun dimers was not altered by drug exposure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of anisomycin on activation of early response genes c fos , c jun , Egr 1 in cells transformed by E1A and cHa ras oncogenes ] . ^^^ Using specific inhibitors of various MAP kinase cascades it has been shown for E1A + ras transformed cells that the anisomycin induced transcription of c fos gene is mainly adjusted through MEK / ERK kinase pathway while high level of c jun gene transcription is supported by activity of JNK kinases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An AP 1 transcription factor complex containing c Fos plays a crucial role in these processes , although results in conditional knockout mice show that Jun family members have a redundant role . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A role for AP 1 was confirmed by over expression of c Jun and c fos in confluent MDA MB 231 cells , showing with c Jun increased MMP 2 ( 5 fold ) , MMP 3 ( 1 . 6 fold ) , and MMP 9 ( 160 fold ) expression , as well as enhanced invasive potential , while TIMP 1 expression was down regulated ( 2 fold ) when compared to vector controls . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fourteen weeks later , the expression of PPARgamma , P 50 ( subunit of NF kappaB ) and c Fos ( subunit of AP 1 ) was determined by indirect immunofluorescence in the aortic endothelial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of c fos and c jun proteins in the marginal division of the rat striatum during learning and memory training . ^^^ The aim of this study was to investigate the expression of the immediate early genes c fos and c jun in the MrD of the striatum during learning and memory processes in the rat , immunocytochemical and Western blot methods were used to examine Y maze trained rats . ^^^ After Y maze training , the expression of the immediate early genes c fos and c jun in the MrD of the rats was investigated using immunocytochemical and Western blot methods . ^^^ RESULTS : After one hour of Y maze training , the expression of c jun and c fos proteins was significantly enhanced in the MrD ; the c jun protein , in particular , was more intensely expressed in this region than in other parts of the striatum . ^^^ Western blot disclosed two immunoreactive bands for the anti c fos antibody ( 47 kD and 54 kD ) and two immunoreactive bands for the anti c jun antibody ( 39 kD and 54 kD ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Striatal neurons of wv / wv mice exhibited age dependent increase in dense cored intra neuronal inclusions , cellular aggregation , proto oncogenes ( c fos , c jun , caspase 3 , and GAPDH ) induction , inter nucleosomal DNA fragmentation , and neuro apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift and chromatin immunoprecipitation assays indicated that LXR agonists inhibit cytokine induced c Fos and phospho c Jun binding to this AP 1 site . ^^^ Cytokine induced c Fos and phospho c Jun protein expression was inhibited by LXR ligands and overexpression of c Fos and c Jun reversed the inhibitory effect of LXR ligands on OPN promoter activity in transactivation assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The role of AP 1 in the hypertrophic phenotype was evaluated with the use of an adenoviral construct expressing a dominant negative mutant of the c Fos proto oncogene ( AdAFos ) . ^^^ CONCLUSIONS : Although c Fos / AP 1 is necessary for induction of the pathological / fetal gene program , it does not appear to be critical for cardiomyocyte hypertrophy . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results indicate that JNK AP 1 pathway has an important role in the potentiation of 1 , 25D ( 3 ) induced differentiation by antioxidants , and regulates expression of Egr 1 and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reporter assays indicated that both EGCG and Poly E inhibited the transcriptional activity of the activator protein 1 ( AP 1 ) , c fos , nuclear factor kappaB , and cyclin D 1 promoters . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with this , overexpression of c jun and c fos in confluent breast cancer cell lines leads to up regulation of MMP expression , proteolytic activity and invasion as well as down regulation of TIMP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Epstein Barr virus ( EBV ) encoded latent membrane protein 1 ( LMP 1 ) may trigger the transcription factor AP 1 including c Jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Four genes previously shown to be associated with TBI ( c Fos , Jun B , HSP 70 , and Zif / 268 ) were all found to be up regulated in at least one TBI patient . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Valproic acid , but not lamotrigine , suppresses seizure induced c fos and c Jun mRNA expression . ^^^ Seizure induced activity has been shown to increase the expression of immediate early genes ( IEGs ) c fos and c Jun in the CNS . ^^^ We found that valproic acid ( VPA ) , but not lamotrigine ( LTG ) , was capable of suppressing seizure induced c fos and c Jun mRNA expression in rats despite a similar anticonvulsant effect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , the polyphenol triggered the phosphorylation of c JUN ( Ser 63 and Ser 73 ) and induced c JUN / c FOS , thereby increasing the DNA binding activity of activator protein 1 ( AP 1 ) , as shown by an AP 1 luciferase reporter assay . ^^^ Our results suggest that some green tea catechins induce pro MMP 7 production via O 2 production and the activation of JNK1 / 2 , c JUN , c FOS and AP 1 in HT 29 cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activating transcription factor 2 ( ATF 2 ) is a member of the activator protein 1 family of transcription factors , which includes c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Similar to ANG 2 , ANG 3 induced the expression of c Fos , c Jun , and Krox 24 in four brain regions , subfornical organ , median preoptic area , paraventricular nucleus , and supraoptic nucleus of the hypothalamus , with the same efficacy . ^^^ Interestingly , the AT ( 2 ) receptor antagonist PD 123319 alone slightly enhanced the expression of c Fos , c Jun , and Krox 24 in different populations of neurons of the paraventricular nucleus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , Tat strongly activates the c Jun component of the multimolecular complex AP 1 , whereas TGF beta triggers c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DL threo 1 phenyl 2 hexadecanoyl amino 3 pyrrolidino 1 propanol ( PPPP ) , which causes accumulation of intracellular ceramide , stimulated the TNF alpha induced expression of the c fos and c jun genes . ^^^ In addition , cell permeable ceramide ( N acetylsphingosine , N hexanoylsphingosine or N octanoylsphingosine ) stimulated expression of the c fos and c jun genes and nuclear protein binding to TRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The early response genes ( c fos , c jun ) , the second message systems ( Ca2+ , NO , cAMP ) and the mechano sensitive cation channel are involved in the mechanotransduction course when osteoblasts respond to the mechanical stimulation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CXCL 16 promoter reporter activity was increased by constitutively active c Fos and c Jun and decreased by dominant negative or antisense c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the effect of 10 mug GDNF and BDNF injected by lumbar puncture on the expression of the immediate early gene ( IEG ) products c Fos , c Jun , and Krox 24 in the adult rat dorsal horn . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several connections were demonstrated between Cox and a few oncogenes ( 5 src , 5 Ha ras , HER 2 \ neu , Wnt , p 53 mutated ) , alimentary products ( PUFAs ) , transcription factors ( c jun and c fos ) , proapoptotic proteins [ Bax et Bcl 10 ( L ) ] or antiapoptotic ( Bcl 2 ) , CYP 19 aromatase gene , NFkappaB receptor ( RANKL ) , angiogenesis ( via VEGF , TXA 2 , oxid nitric synthetase , alphaVbeta 3 integrin receptor ) , peroxisome gamma proliferator receptor ( PPARgamma ) and its ligand PGJ 2 and with antitubuline chemotherapy drugs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This phenotype was related to an increase in c Jun and c Fos expression and extinction of tumor suppressor gene expression ( p 53 , p21WAF1 , Rb 3 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Instead , IL 4 treatment ( but not IL 13 treatment ) was associated with an increased activity of ERK1 / 2 and c Fos , the downstream target of ERK1 / 2 and component of the transcription factor AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Preconditioning effects on expression of proto oncogenes c fos and c jun after hepatic ischemia / reperfusion in rats . ^^^ The purpose of this research was to investigate the effects of preconditioning on expression of immediate early genes c fos and c jun following hepatic ischemia / reperfusion ( IR ) and its roles in cellular regeneration and apoptosis . ^^^ After 0 , 0 . 5 , 1 , 2 , 4 , 8 , 12 , 24 hour reperfusion , the serum and liver tissue in each group were collected to detect the level of serum ALT / AST , liver histopathology , expression of c fos , and c jun mRNA . ^^^ Expressions of c fos and c jun mRNA were low , especially c jun at 0 . 5 , 1 and 2 hours after reperfusion . ^^^ CONCLUSION : Ischemic preconditioning can protect liver cells against ischemia / reperfusion injury , and this protective effect may be related to influence transcription levels of c fos and c jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The surface activity of c Jun , together with that of c Fos , its common partner in AP 1 transcription heterodimers , drives interfacial complex formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , our data suggest the implication of c Fos on the induction of the main angiogenic factor VEGF since the promoter region of the VEGF gene possesses AP 1 ( i . e . , c Fos / c Jun heterodimer ) response elements . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All assayed transcription factors were up regulated by 12 h , but only c fos and c jun up regulation persisted to the 48 h time point . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Additionally , PGF2alpha rapidly and transiently stimulated the expression of immediate early response genes , i . e . c fos and c jun mRNA , further suggesting a mitogenic effect for this prostaglandin in LEC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
There were also increases in synaptophysin and syntaxin 1 expressions in the sound enriched groups and modulation of the developmental expression of transcription factors c Fos and c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , inhibition of ERK and JNK by EPA resulted in the decrease of c Fos expression and c Jun phosphorylation / expression induced by UV , respectively , which led to the inhibition of UV induced activator protein 1 DNA binding activity . ^^^ In conclusion , our results demonstrate that EPA can inhibit UV induced MMP 1 expression by inhibiting the MEK1 / ERK / c Fos and SEK1 / JNK / c Jun pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Congenital iodine deficiency and hypothyroidism impair LTP and decrease C fos and C jun expression in rat hippocampus . ^^^ In hippocampus of pup rats , the induction of LTP in area CA 1 was determined on PN 60 and the expression of c fos and c jun proteins was examined on PN 20 , PN 30 and PN 60 . ^^^ Compared to control pups , both treated groups have shown : ( 1 ) significantly lower concentrations of serum FT ( 3 ) and FT ( 4 ) , ( 2 ) much smaller population spike ( PS ) amplitude ( p < 0 . 01 ) and field excitatory postsynaptic potential ( f EPSP ) slope induced by high frequency stimulation ( HFS ) ( P < 0 . 01 ) , and ( 3 ) significantly lower integrated optical density ( IOD ) total of c fos and c jun expression ( P < 0 . 05 or P < 0 . 01 ) . ^^^ In summary , iodine deficiency and hypothyroidism during critical periods of brain development impair LTP induction and decrease the expression of c fos and c jun proteins in hippocampus . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of group 1 metabotropic glutamate receptors evokes calcium signals and c jun and c fos gene expression in human T cells . ^^^ Finally , specific stimulation of these receptors in Jurkat cells upregulates c jun and c fos gene expression , thus activating multiple downstream signalling regulating important T cell functions . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 family and Blimp 1 mRNAs were transiently induced in the control B cells , and overexpression of c Fos induced a sufficient amount of Blimp 1 for terminal differentiation in the H 2 c fos B cells . ^^^ However , expression of c fos / AP 1 family mRNAs in LPS stimulated normal B cells was similar to that of normal B cells stimulated with CD40L and IL 4 . ^^^ Thus , although c Fos is not essential for Blimp 1 expression , c Fos / AP 1 positively regulates Blimp 1 expression and terminal differentiation of activated B cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Also , DADLE at 1 pM selectively increases c Jun and c Fos , but not c Rel . ^^^ These results indicate that DADLE is one of the most potent agents in increasing the NGF in the biological system and that this action of DADLE involves selective increases of c Jun and c Fos , transcription factors that promote the NGF expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The heart weight / body weight ratio , cardiac muscle cell cross sectional area ( CSA ) , interstitial collagen volume fraction ( CVF ) and the ratio of perivascular collagen area to vessel luminal area ( PVCA ) were calculated , the expression of alpha 1 adrenergic receptor , c fos and c Jun in heart were measured by RT PCR , Western blotting and immunohistochemistry . ^^^ RT PCR showed that the expression of alpha1D adrenergic receptor mRNA of the immunization group was 0 . 55 + / 0 . 01 , significantly lower than that of the normal control group ( 0 . 88 + / 0 . 08 , P < 0 . 05 ) ; the expression of c jun mRNA in the immunization group was 0 . 82 + / 0 . 02 , significantly higher than that in the normal control group ( 0 . 42 + / 0 . 07 , P < 0 . 05 ) ; and there were no significant differences in the expressions of heart alpha1A and alpha1B afrenergic receptors and c fos mRNAs between these 2 groups . ^^^ Western blotting showed that the expression of c jun protein in the immunization group was 6 . 24 + / 2 . 13 , significantly higher than that in the normal control group ( 2 . 55 + / 0 . 58 , P < 0 . 05 ) ; and there were no significant differences in the expressions of c fos andalpha1A adrenergic receptor proteins between these 2 groups . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of NMDA receptors will also lead to activation of the early gene transcription factors including AP 1 ( c fos , c jun ) and NF kappaB which may play a role in modulation of the subsequent response to hypoxia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Additionally , phosphorylation of JNK and activation of the transcription factor , c jun and c fos was also observed in response to rF 1 treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
G 17 also stimulated tyrosine phosphorylation of ERKl / 2 , p 38 , FAK , and paxillin , and up regulated the mRNA expression of early response gene c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The objective of this study was to examine temporal expression patterns of early responsive genes ( Sox 9 , c Fos , c Jun , and TGF beta type 1 and 2 receptors ) and induction of their corresponding proteins in agarose culture of rabbit BM MSCs subjected to cyclic compressive loading . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes c fos , fosB , and c jun were not detected , whereas junB was induced by IL 5 stimulation in both types of cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , IFN alpha stimulates the expression of the primary response genes c fos and egr 1 , which was followed by an increase in DNA binding activity of c FOS and EGR 1 proteins , as verified by shift assays using the cis acting elements AP 1 and EGR 1 localized at the alpha ENO promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has been shown that mice lacking the AP 1 family member c Fos exhibit an impaired transition from benign to malignant skin tumors . ^^^ Within the Rab11a gene promoter , we identified a functional AP 1 binding element that exhibited elevated c Fos binding activity after TPA treatment of keratinocytes . ^^^ These data identify Rab11a as a novel , tumor associated c Fos / AP 1 target and may point to an as yet unrecognized function of Rab11a in the development of skin cancer . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The basal protein and mRNA levels and nuclear binding activities of c Jun , c Fos , p 50 , and p 65 were lower in F 1 and F 2 cells and exhibited a blunted response to TBH . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment with HNE increased ERK phosphorylation , c Fos protein , JNK phosphorylation , c Jun phosphorylation , and AP 1 binding . ^^^ Whereas inhibiting the ERK pathway with the MEK inhibitor PD 98059 significantly decreased HNE mediated ERK phosphorylation , c Fos protein induction , AP 1 binding , and HO 1 protein induction , inhibition of the ERK pathway had no effect on HNE induced HO 1 mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 induced the nuclear transcription factor activator protein 1 family , including the c Jun , JunD , c Fos , FosB , and Fra 1 proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When H 3 WT was overexpressed , EGF induction of c fos and c jun promoter activity was significantly increased compared with control cells but not in the H 3 mutant S10A or S28A cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c fos and c jun genes after kainate stimulation . ^^^ Kainate stimulation induces the expression of immediate early genes , c fos and c jun genes . ^^^ Trichostatin A ( TSA ) , a potent histone deacetylase ( HDAC ) enzyme inhibitor was used to test the role of histone hyperacetylation in the transcriptional regulation of c fos and c jun genes in neuronal cells in vivo and in vitro . ^^^ TSA did not prolong the expression of c fos or c jun gene , in contrary to what we expected . ^^^ Primary hippocampal neuron cell culture also displayed a similar pattern of c fos and c jun mRNA enhancement with trichostatin A pretreatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Down regulation of CYP2J2 in hypoxic HepG 2 cells was closely associated with the up regulation of c fos and transient transfection analysis demonstrated that c Fos abolishes the activation of CYP2J2 by the AP 1 protein c Jun . ^^^ In contrast to the behaviour of the 56 / 63 element , c Jun homodimers and c Fos / c Jun heterodimers bound to the 105 / 95 element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After exposure to the compound , the modulated genes were involved in inflammatory responses as with the mitogen activated protein kinase 14 ( MPK 14 ) , or in tumor and metastasis progression as with the matrix metalloproteinase 17 ( MMP 17 ) , in cell proliferation as with c jun and c fos , and moreover in the apoptotic process as with interferon alpha inducible protein ( IFI ) , BAX and BCL 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Anti AT 1 receptor antibodies purified by affinity chromatography were prepared to detect their effect on vascular smooth muscle cell ( VSMC ) proliferation by the method of bromodeoxyuridine incorporation and cell cycle distribution , and their effect on the expression of VSMC c jun and c fos mRNA by reverse transcription polymerase chain reaction and Western blot . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
First , SHRs had higher expression levels of c fos and c jun genes , which encode the component of the AP 1 transcription factor that activates NGF gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Puerarin reduces increased c fos , c jun , and type 4 collagen expression caused by high glucose in glomerular mesangial cells . ^^^ AIM : Increased expression of c fos , c jun and type 4 collagen ( CoIV ) in glomerular mesangial cells ( GMC ) are important characteristics of diabetic nephropathy . ^^^ Both c fos and c jun regulate the gene expression of extracellular matrix components , and CoIV is the main component of the extracellular matrix . ^^^ The aim of this study is to investigate the effect of puerarin on c fos , c jun and CoIV expression in GMC cultured in medium containing 5 . 6 or 27 . 8 mmol / L glucose . ^^^ METHODS : The expressions of c fos and c jun were measured at the protein level using flow cytometry . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mechanistic studies to determine the potential of deguelin to block a number of established UVB induced molecular events yielded negative results [ including UVB induced AP 1 DNA binding , c fos and TNFalpha mRNA induction , arachidonic acid release and UVB induced phosphorylation of mTOR ( Ser 2448 ) , akt ( Ser 473 ) and erk ( Thr202 / Tyr204 ) ] . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased activity of activator protein 1 transcription factor components ATF 2 , c Jun , and c Fos in human and mouse autosomal dominant polycystic kidney disease . ^^^ Here , it is reported that activity of the AP 1 components c Jun , ATF 2 , and c Fos is altered in renal cystic tissue of patients with autosomal dominant polycystic kidney disease and of hypomorphic Pkd 1 mice with polycystic kidney disease . ^^^ Significant upregulation of Thr 71 and Thr69 / 71 phosphorylated ATF 2 and Ser 73 phosphorylated c Jun and increased c Fos were detected in small cysts and ( dilated ) ducts and tubules surrounded by fibrotic interstitium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Assessment of c Jun , c Fos and cyclin D 1 in premalignant and malignant oral lesions . ^^^ In the present study , the expression of c Jun , c Fos , and cyclin D 1 proteins in oral epithelial lesions with different degrees of dysplasia , and in oral squamous cell carcinomas ( OSCCs ) was evaluated . ^^^ Results : c Jun expression increased according to the degree of oral dysplasia , with the greatest expression found in OSCC . c Fos expression was intense in normal mucosa , reduced in mild dysplasia and high in moderate to severe dysplasia and in OSCCs . ^^^ The present results indicate a possible role of c Jun and c Fos in malignant transformation of oral mucosa . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several MAPK regulated host transcription factors such as c Jun , STAT1alpha , MEF 2 , c Myc , ATF 2 and c Fos were induced early during infection , and ERK inhibition significantly blocked the c Fos , c Jun , c Myc , and STAT1alpha activation in the infected cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Down regulation of c Fos / c Jun AP 1 dimer activity by sumoylation . ^^^ The inducible transcriptional complex AP 1 , composed of c Fos and c Jun proteins , is crucial for cell adaptation to many environmental changes . ^^^ Using nonsumoylatable mutants of c Fos and c Jun as well as a chimeric protein mimicking sumoylated c Fos , we show that sumoylation entails lower AP 1 transactivation activity . ^^^ We report here that lysine 265 of c Fos is conjugated by the peptidic posttranslational modifiers SUMO 1 , SUMO 2 , and SUMO 3 and that c Jun can be sumoylated on lysine 257 as well as on the previously described lysine 229 . ^^^ Sumoylation of c Fos preferentially occurs in the context of c Jun / c Fos heterodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of c fos and c jun immediate early genes was increased 30 min after glutamate exposure . ^^^ The study of c Fos and c Jun protein expression revealed an increase in the number of cells positive for both antibodies . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Long term activation of c Fos and c Jun in optic nerve head astrocytes in experimental ocular hypertension in monkeys and after exposure to elevated pressure in vitro . ^^^ This study investigates whether the immediate early gene ( IEG ) products c Fos and c Jun are activated in vivo in monkeys with experimental glaucoma , and in vitro in cultured human ONH astrocytes exposed to hydrostatic pressure ( HP ) . ^^^ ONH tissues were stained with GFAP , DAPI , and c Jun or c Fos , and transcription factor positive and negative nuclei were counted to determine nuclear localization . ^^^ Activation and nuclear localization of c Fos and c Jun increased significantly in the monkeys with elevated IOP . ^^^ Cultured human ONH astrocytes showed increased nuclear localization of c Fos and c Jun under exposure to HP . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These events lead to the down modulation of c Jun , c Fos , Egr 1 , and NF kappaB transcription factors and thereby inhibit production of cytokines , e . g . , IL 2 , IL 4 , IFN gamma , and TNF alpha , upon TCR stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activations of c fos / c jun signaling are involved in the modulation of hypothalamic superoxide dismutase ( SOD ) and neuropeptide Y ( NPY ) gene expression in amphetamine mediated appetite suppression . ^^^ Results showed that AMPH treatment decreased food intake , which was correlated with changes of NPY mRNA level , but increased c fos , c jun and superoxide dismutase ( SOD ) mRNA levels in hypothalamus . ^^^ To determine if c fos or c jun was involved in the anorectic response of AMPH , infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats , and the results showed that c fos or c jun knockdown could block this anorectic response and restore NPY mRNA level . ^^^ Moreover , c fos or c jun knockdown could partially block SOD mRNA level that might involve in the modulation of NPY gene expression . ^^^ It was suggested that c fos / c jun signaling might involve in the central regulation of AMPH mediated feeding suppression via the modulation of NPY gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNA expressions of C / EBPbeta , C / EBPdelta , C / EBPgamma , c Jun , JunB , c Fos , Fra 1 and IkappaBalpha and protein level of IkappaBalpha were all unaffected by VIP . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our data indicated that treatment of dermal fibroblasts with stratifin resulted in rapid and transient upregulation of c jun and c fos mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that c fos , Jun B , Jun D and p c Jun were super shifted by ADR , indicating that these proteins have an important role in the ADR induced AP 1 activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : Extracellular regulated kinase ( ERK ) and c Jun NH terminal kinase ( JNK ) phosphorylation , c fos mRNA expression , and activator protein 1 ( AP 1 ) DNA binding activity stimulated by TGF beta 1 were completely suppressed by the ERK kinase ( MEK ) inhibitors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among the downstream effectors of ERK examined , we found that Epimedin C selectively decreased the expression of c Fos , but not c Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The activation of the activating protein 1 ( AP 1 ) family of transcription factors , including c Fos and c Jun family members , is one of the earliest nuclear events induced by growth factors that stimulate extracellular signal regulated kinases ( ERKs ) . ^^^ Our findings suggest that c Fos represents a novel target for the isomerizing activity of Pin 1 and support a role for Pin 1 in the mechanism by which c Jun and c Fos can cooperate to regulate AP 1 dependent gene transcription upon phosphorylation by mitogen activated kinase ( MAPK ) family members . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neither PDT nor heat damaged cells induced changes in mRNA expressions for GADD 45 , P 21 ( WAF / cip1 ) , C JUN , C FOS , and BAX in the bystander cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The combination of c Fos and c Jun or c Fos and JunD strongly suppresses hTERT promoter activity in transient expression analyses . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Pretreatment of PC 12 cells with c fos antisense oligonucleotide abolished the NO induced increase in DNA binding of AP 1 and upregulation of COX 2 expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Co transfection of c jun and c fos expression vectors , or p 65 and p 50 expression vectors , rescued decreased CAT activity by RXM , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we found that among the immediate early serum responsible genes , exemplified by c jun , c fos and c myc , induction of c jun in a human bronchial epithelial cell line , BEAS 2B , was dependent on anchorage , in contrast to clear induction of c fos and c myc under both anchorage dependent and independent conditions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Up regulation correlated with activator protein ( AP ) 1 activation , notably c Jun and c Fos that bind cognate elements in the ICP 10 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Macrophage colony stimulating factor ( M CSF ) , receptor activator of NF kappaB ligand ( RANKL ) , and other osteoclastogenic ligands activate the NF kappaB components p 50 or p 52 , the AP 1 component c Fos , and NFATc 1 in osteoclast precursors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our team designed anti c Fos drugs that specifically inhibit action of c Fos at the AP 1 consensus sequence by using a computer assisted drug design , which was the front runner work executed in Japan . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
During 7 days after the intraperitoneal injection of MNU ( 60 mg / kg ) , rat retinas exhibited DNA fragmentation characteristic of apoptosis and activation of PARP , phosphorylation of JNK and c Jun , induction of AP 1 ( c Jun and c Fos ) and Bax , as well as photoreceptor cell loss . ^^^ However , when NAM ( 1000 mg / kg , subcutaneously ) was given immediately after MNU , it was found that PARP activation was diminished , the phosphorylation of JNK and c Jun was suppressed , and the induction of c Jun , c Fos and Bax was suppressed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A treatment with silibinin to A 549 cells also led to a dose dependent inhibition on the activation of NF kappaB , c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The specificity of AP 1 binding for relevant DNA motifs was confirmed by competition EMSA and by supershift EMSA using antibodies specific to c Jun and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , we established that overexpressed c fos and c jun partially abolished the ability of retinoids to inhibit AP 1 activity , suggesting that c jun and / or c fos containing dimers may constitute one target of retinoids for transrepression of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , we evaluated the effect of increasing doses of cocaine on the expression of immediate early genes ( IEGs ) , c fos and c jun , and closely related transcription factors , SP 1 and NF kbeta , at 24 h after the exposure to cocaine ( 50 , 100 , 200 , 500 , 1000 , 2500 microM ) in NGF differentiated PC 12 cells . ^^^ Cocaine ( 50 500 microM ) resulted in significant induction of the expression of c fos , c jun , SP 1 , and NF kbeta . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunodepletion gel shift assays demonstrated that GP 5 EpRE bound JunB , c Jun , FosB , and Fra 2 from unstimulated cells , and that after exposure to HNE , EpRE binding complexes contained nuclear factor erythroid 2 related factor ( Nrf ) 1 , Nrf 2 , JunB , c Jun , FosB , c Fos , Fra 1 , and Fra 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Members of the Fos family ( c Fos , FosB and its smaller splice variants , Fra 1 and Fra 2 ) dimerise with Jun proteins to form the AP 1 transcription factor complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , using the rat as an animal model of domoic acid intoxication , we compared histochemical staining of the limbic system and especially the hippocampus with degeneration selective techniques ( Fluoro Jade and silver ) , a conventional Nissl stain for cytoplasm ( Cresyl violet ) , a myelin selective stain ( Black Gold ) , an astrocyte specific stain ( glial fibrillary acidic protein ) , early / immediate gene responses ( c Fos and c Jun ) , as well as for heat shock protein ( HSP 72 ) and blood brain barrier integrity ( rat IgG ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The essential roles of NF kappaB and AP 1 in osteoclast differentiation have been clearly demonstrated in numerous studies . c Fos , a component of AP 1 transcription factor , plays a key role in osteoclast differentiation . ^^^ Momordin 1 remarkably inhibited the activation of NF kappaB as well as AP 1 in RANKL induced RAW264 . 7 cells , in which momordin 1 appeared to target IkappaB degradation and c Fos expression , respectively , but not MAPK signaling pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In archived biopsies from 15 healthy subjects exposed to DE [ particulates with a mass median diameter of < 10 mum , 300 microg / m3 ] and air , immunohistochemical staining was used to quantify the expression of the transcription factors NF kappaB ( p 65 ) and AP 1 ( c jun and c fos ) , as well their upstream MAPKs , p 38 and JNK , in the bronchial epithelium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of SLE T cells with PP2Ac siRNA decreased the protein levels and activity of PP2Ac in a specific manner and increased the levels of phosphorylated cAMP response element binding protein and its binding to the IL 2 and c fos promoters , as well as increased activator protein 1 activity , causing normalization of IL 2 production . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the nuclear transcription factors c Fos and c Jun in the paraventricular nucleus ( PVN ) and arcuate nucleus ( ARC ) of the hypothalamus of obese Zucker rats was studied using immunohistochemical methods . ^^^ It was observed that the numbers of c Fos positive and c Jun positive neurons in these regions decreased in obese rats compared to lean rats , and that difference was more evident in the ARC than in the PVN which has to do with the regulation of body weight . ^^^ The reduction in expression in the ARC of obese rats was greater for c Jun than for c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vivo , 14 3 3 is inducibly recruited to c fos and c jun nucleosomes upon gene activation , concomitant with H 3 phosphoacetylation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpressions of CREB and c Jun , but not c Fos , also significantly increased the promoter activity , which suggests that CREB and c Jun are the crucial transcription factors involved in regulating nectin 2 gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ischemia induced the expression and binding of c Fos , c Jun , JunB , FosB , and Fra 2 to a noncanonical activating protein 1 ( AP 1 ) site present in the MMP 2 promoter and decreased binding of the transcriptional repressor JunD . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has also been shown that extracellular signal regulated kinase activation can regulate cocaine induced expression of c Fos and FosB , two possible components of activator protein 1 . ^^^ SL 327 pre treatment , however , reduces the DNA binding activity of the activator protein 1 complex induced six hours after an acute cocaine treatment as well as one hour after the last of the chronic cocaine injections , a phenomenon that results from the concomitant reduction of all cocaine induced proteins ( c Fos , FosB , deltaFosB , JunB ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Function of c Fos like and c Jun like proteins on trichostatin A induced G2 / M arrest in Physarum polycephalum . ^^^ The homologs of transcription factors c Fos and c Jun have been detected in slime mold Physarum polycephalum during progression of the synchronous cell cycle . ^^^ Here we demonstrated that c Fos like and c Jun like proteins participated in G2 / M transition by the regulation of the level of Cyclin B 1 protein in P . polycephalum . ^^^ The study of antibody neutralization revealed that interruption of the functions of c Fos like and c Jun like proteins resulted in G2 / M transition arrest , implicating their functional roles in cell cycle control . ^^^ When G2 / M transition was blocked by histone deacetylase inhibitor trichostatin A , changes in c Fos and c Jun like protein levels , and hyperacetylation of c Jun like protein , were observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we first investigated the effect of IL 1 on MAPK activity , c Jun and c Fos mRNA expression , and MMP 1 and MMP 2 production in UVA irradiated human dermal fibroblasts . ^^^ Both IL 1alpha and IL 1beta activated MAP kinase , significantly elevating c Jun and c Fos mRNA expression . ^^^ IL 1Ra dose dependently inhibited c Jun mRNA expression of fibroblasts with no significant effect on c Fos mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IEGs such as c fos and c jun were induced in the retina of the glaucomatous rat as early as 2 hr after the onset of glaucoma and lasted up to 2 weeks . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , we investigated the effects of these antagonists on intracellular signalling pathways of protein kinase C ( PKC ) , mitogen activated protein kinases ( MAPK ) and c fos and c jun oncogenes that are involved in tumour cell proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Indeed , E ( 2 ) stimulated estrogen receptor ( ER ) alpha and beta protein levels and increased mRNA expression levels of protooncogenes ( c fos , c jun , and c myc ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Estrogen receptor ( ER ) beta modulates ERalpha mediated transcriptional activation by altering the recruitment of c Fos and c Jun to estrogen responsive promoters . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 subunits , c Jun and c Fos , were responsible for the constitutive occupancy at the proximal region . ^^^ AP 1 subunits , c Jun and c Fos , were responsible for the constitutive occupancy at the proximal region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : Hyperosmolarity ( 405mosmol / l ) increased MKP 1 expression by MG 132 , which was accompanied by an induction of c Fos , c Jun , cJun Ser 73 phosphorylation , and AP 1 DNA binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We will focus on some results from our group within this context and summarize some recent evidence for the active involvement of extrinsic ( myelin basic protein ) , integral ( Folch Lees proteolipid protein ) and amphitropic ( c Fos and c Jun ) proteins , as well as a membrane active amphitropic phosphohydrolytic enzyme ( neutral sphingomyelinase ) , in the process of lateral segregation and dynamics of phase domains , sculpturing of the surface topography , and the bi directional modulation of the membrane biochemical reactivity . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 DNA binding complex in control and ethanol treated nuclear extract was composed of c Fos , FosB , c Jun , JunD , and phosphorylated CREB ( p CREB ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JNK / ERK MAPKs and their downstream effectors , c Jun and c Fos ( AP 1 ) , are involved in chondroblastic differention / proliferation . ^^^ We evaluated the cellular levels of JNK 2 , p JNK 2 ( phosphorylated / activated JNK 2 ) , its main substrate , c Jun , pc Jun ( phosphorylated / activated c Jun ) and c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Concomitantly , the PPARgamma ligands diminished the cellular amount of mRNA encoding for IL 6 , CXCL 8 and CCL 5 and the RSV induced binding activity of the transcription factors NF kappaB ( p65 / p50 ) and AP 1 ( c fos ) , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of mRNA for IL 2 and the NF kappaB dependent gene A 20 and of the AP 1 components c fos and c Jun was examined by quantitative RT PCR . ^^^ In contrast , NF ATp dephosphorylation and nuclear localization , nuclear AP 1 binding activity , and expression of c fos , but not c Jun , were all impaired . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential bindings of the CREB 1 , ATF 2 , c jun to the CRE site , and the c fos , c jun , ATF 2 to the AP 1 site are demonstrated by DNA affinity protein binding , supershift , and chromatin immunoprecipitation assays . ^^^ These results indicate that H . pylori acts through TLR 2 and TLR 9 to activate MAPKs , especially p 38 , and their downstream transcription factors ( CREB 1 , ATF 2 , c jun , and c fos ) , resulting in the activations of CRE and AP 1 on the COX 2 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The electrophoretic mobility shift assay revealed that TNF alpha triggered AP 1 and DNA binding and again , NS 398 and meloxicam inhibited this reaction via reducing c Fos synthesis . ^^^ Furthermore , COX 2 facilitates CCL 2 transcription in NPFs via a c Fos and AP 1 signaling pathway . . ^^^ A transient elevation of c Fos and c Jun messenger RNAs was induced by TNF alpha , whereas COX 2 inhibitors NS 398 and meloxicam abolished the up regulation of c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While anti CR 1 had no effect on the activation of the immediate early genes c jun or c fos nor on the early increase of gamma interferon or interleukin 2 specific RNA , the protein synthesis of those cytokines was inhibited . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Subgroup analysis showed tumor specific binding for c Fos in 58 % , for c Jun in 50 % , for JunD in 39 % , and for Fra 1 in 4 % of cases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AOM treatment induced c Jun and c Fos expressions in the liver but increased only Fos B in the colon , whereas T cell deficiency enhanced c Jun overexpression in the liver . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The upstream mediators of the effect involved c jun , c fos and NF kappaB , as evidenced by reduced phosphorylation of the proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
KA increased the phosphorylated extracellular signal regulated kinase ( p ERK ) and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( p CaMK 2 ) immunoreactivities ( IRs ) 30 min after KA treatment , and c Fos , c Jun IR 2 h , and glial fibrillary acidic protein ( GFAP ) , complement receptor type 3 ( OX 42 ) IR 1 day in hippocampal area in KA injected mice . 5 AV attenuated KA induced p CaMK 2 , GFAP and OX 42 IR in the hippocampal CA 3 region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antisense RIalpha in the liver induced the phase 2 enzymes , glutathione S transferase and quinone oxidoreductase , c fos protein , and activator protein 1 ( AP 1 ) and cAMP response element ( CRE ) directed transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast treatment with pure compound showed no inhibitory effect on ERK . c fos and c jun mRNA levels were also reduced in PMA stimulated cells on treatment with crude extract and pure compound . ^^^ This reduction in c fos and c jun levels , when taken together with inhibition of MAPK activation , provides a possible mechanism by which both crude ethyl acetate extract and purified compound isolated from C . mukul exert its action . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transportin is a major nuclear import receptor for c Fos : a novel mode of cargo interaction . c Fos , a component of the transcription factor AP 1 , is rapidly imported into the nucleus after translation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expressions of the immediate early genes , c fos and c jun , and their product proteins C FOS , C JUN , and P JUN were examined in the hippocampal CA 1 subfield after global ischemia and reperfusion in rats treated with cyclosporin A . ^^^ The expressions of c fos and c jun mRNA in the control animals were detected with an increase from 1 to 48 h after ischemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , c fos and c jun were found in the cell nuclei after RGDS treatment , suggesting that the RGDS effect could be mediated by the AP 1 transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This difference between c fos and c jun expression on pHA after 0 . 5 h could be related to the fact that these two genes may differ in their signalling pathways . ^^^ Indeed , the signal transduction pathways involved in adhesion of Saos 2 cells on HA and titanium were confirmed by the sequential expression of alphav and beta 1 integrins , FAK , and ERK genes followed by the expression of c jun and c fos genes for proliferation and alkaline phosphatase gene for differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A mechanism of AP 1 suppression through interaction of c Fos with lamin A / C . ^^^ Here we show that the intermediate filament protein lamin A / C suppresses AP 1 function through direct interaction with c Fos , and that both proteins can interact and colocalize at the nuclear envelope ( NE ) in mammalian cells . ^^^ In vitro , preincubation of c Fos with lamin A prior to the addition of c Jun inhibits AP 1 DNA binding activity . ^^^ In vivo , overexpression of lamin A reduces the formation of c Fos / c Jun heterodimers , and suppresses AP 1 DNA binding and transcriptional activity . ^^^ Notably , c Fos colocalizes with lamin A / C at the NE in starvation synchronized quiescent cells lacking detectable AP 1 DNA binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of c fos and c jun was also abrogated in mesangial cells pre exposed to MphiCM , and the suppression was attenuated by blockade of MAPK activation during the first exposure to MphiCM . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Brains were fixed by transcardial perfusion and frozen sections were stained with polyclonal antibodies directed against three immediate early gene encoded proteins , c Fos , c Jun , and Krox 24 ( NGFI A , Egr 1 , Zif 268 , Tis 8 , Zenk ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Persistent oxidative stress in cancer may also cause activation of transcription factors and protooncogenes such as c fos and c jun as well as genetic instability . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present study has shown that cell preparation procedure , i . e . , cell collection by centrifugation and the subsequent adjustment and culture of cell density at the desired concentrations , transiently induced gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) and the AP 1 components ( c fos , c jun , and junB ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , almost all kinds of the AP 1 family genes including c jun , c fos , junD , junB , atf 2 and b atf were successfully selected from an mRNA display library constructed from a mouse brain poly A ( + ) RNA after six rounds of selection . ^^^ Under improved selection conditions using a TPA responsive element ( TRE ) as a bait DNA , known interactors c fos and c jun were simultaneously enriched about 100 fold from a model library ( a 1 : 1 : 20 000 mixture of c fos , c jun and gst genes ) after one round of selection . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of immediate early genes ( c fos , c jun , and c myc ) was augmented and activator protein 1 DNA binding activity was enhanced in untrained rats immediately after a single bout of exercise . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Avian fibroblasts transformed simultaneously by the 5 myc and 5 mil ( raf ) oncogenes of acute leukemia and carcinoma virus MH 2 contain elevated levels of c Fos and c Jun , major components of the transcription factor complex AP 1 . ^^^ Electrophoretic mobility shift assays , chromatin immunoprecipitation and transcriptional reporter gene analyses showed that c Fos and c Jun bind specifically to this site and that c Fos efficiently transactivates the OPN promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ganglioside GM 3 promotes cell migration by regulating MAPK and c Fos / AP 1 . ^^^ Finally , sustained expressions of c Fos in GM 3 KO MEFs were shown to correlate with DNA binding activity between c Fos and AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of transcription factors c Fos , c Jun , CREB 1 and ATF 2 , and caspase 3 in relation with abnormal tau deposits in Pick ' s disease . ^^^ In order to better understand the possible role of selected transcription factors and members of the caspase family in cell death and cell survival , immunohistochemistry to c Fos , c Jun , CREB 1 , ATF 2 ; c Fos ( P ) , c Jun ( P ) and CREB 1 ( P ) ; and procaspase 8 , procaspase 3 and active ( cleaved ) caspase 3 immunohistochemistry was carried out in the frontal cortex and hippocampus . ^^^ Increased expression of c Fos , c Jun , CREB 1 and ATF 2 was observed in PiD cases . ^^^ Increased c Fos ( P ) , c Jun ( P ) and CREB 1 ( P ) was also found in the nuclei of neurons in diseased brains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gene expression profile of MMP 2 , MMP 9 , MT 1 MMP , fibronectin , procollagen type 1 , c fos and c jun , were determined by quantitative real time ( qRT ) PCR . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The first involves PKCdelta , ERK phosphorylation and c Fos accumulation , whilst the second requires another PKC isoform that induces the phosphorylation of c Jun . c Fos and c Jun jointly form an active AP 1 complex , which functions to activate the lytic cascade of KSHV . . ^^^ This inhibition prevented c Fos accumulation , yet increased c Jun phosphorylation . ^^^ Notably , the PKC inhibitor GF 109203X reduced ERK1 / 2 phosphorylation , c Fos accumulation , c Jun phosphorylation and KSHV reactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mitogen and stress activated protein kinase 1 is critical for interleukin 1 induced , CREB mediated , c fos gene expression in keratinocytes . c fos , which encodes a transcription factor of the AP 1 family , is a prototypical immediate early gene induced by a number of proinflammatory cytokines including interleukin 1 ( IL 1 ) , the latter being an important regulator of skin homeostasis . ^^^ Simultaneous activation of several of the mitogen activated protein kinase ( MAPK ) cascades occurred in response to IL 1 , but each differentially contributed to c fos induction by IL 1 , with the p38 / MAPK being the most crucial of all , the extracellular signal regulated kinase pathway contributing in an additive manner and the Jun N terminal kinase pathway playing little , if any , role . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of IL 10 is dependent on TLR 2 and dectin 1 mediated activation of ERK MAPK via a mechanism independent of the activation protein 1 ( AP 1 ) transcription factor c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition to induction of c fos and c jun immediate early genes ( IEGs ) expression in mouse hippocampus , we also found the upregulation of acetylation and phosphorylation of histones , coupled with status epilepticus after kainate administration . c fos and c jun mRNA were sequentially induced in response to kainate , in different hippocampal subpopulations , starting from the dentate gyrus ( DG ) and spreading to the cornus ammonis regions . ^^^ Immunohistochemical analysis showed that the spatio temporal distribution of histone H 4 hyperacetylation after kainate treatment was well correlated with the expression of c fos and c jun genes . ^^^ Chromatin immunoprecipitation analysis showed that both histone modifications were associated with c fos gene promoter after kainate stimulation , but only histone acetylation with c jun gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel shift , enzyme linked immunosorbent , and chromatin immunoprecipitation assays revealed a strong induction of IL 18 mediated AP 1 ( c Fos , c Jun , and Fra 1 ) and NF kappaB ( p 50 and p 65 ) activation and stimulation of MMP 9 promoter dependent reporter gene activity in an AP 1 and NF kappaB dependent manner . ^^^ Ectopic expression of p 65 , c Fos , c Jun , and Fra 1 induced MMP 9 promoter activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Taps represents a potential AP 1 target gene because TPA induced expression in epidermal keratinocytes critically depends on c Fos , and co treatment with dexamethasone , a potent inhibitor of AP 1 mediated gene regulation , resulted in impaired activation of Taps expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased expression of c fos and c jun in the rat small intestinal epithelium after ischemia reperfusion injury : a possible correlation with the proliferation or apoptosis of intestinal epithelial cells . ^^^ BACKGROUND AND PURPOSE : An increased expression of immediate early genes , such as the c fos and c jun , is observed in some organs after ischemia reperfusion ( I / R ) injury . ^^^ Semiquantitative reverse transcription polymerase chain reaction was used to quantify c fos and c jun messenger RNAs . ^^^ RESULTS : The messenger RNA levels of the c fos and c jun showed characteristic patterns in the IECs after the I / R stress . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although GC 1 induced hepatocyte proliferation was associated with a rapid increase in cyclin D 1 mRNA levels , no change in the expression of c jun and c fos was observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The restoring effect of EPO in the RAW264 . 7 cells was associated with the increased of c Fos and c Jun expression as well as AP 1 activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have found the upregulation of acetylation and phosphorylation of histones , coupled with status epilepticus after kainate administration . c fos and c jun mRNA have been sequentially induced in response to kainate , in different hippocampal subpopulations starting from the dentate gyrus and spreading to the cornus ammonis regions well correlated with the spatio temporal distribution of histone H 4 hyperacetylation . ^^^ Both histone modifications are associated with the c fos gene promoter after kainate stimulation , while only histone acetylation with the c jun gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both inhibited the activation of the transcription factor NF kappaB , but had no effects on activation of the AP 1 subunits c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , the phosphorylation of ERK1 / 2 and JNK and the expression of the early response genes c jun , c fos , ATF 3 and egr 1 induced by camostat feeding were not affected by rapamycin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Under conditions in which ICAM 1 and VCAM 1 were expressed , the regulatory AP 1 proteins c Fos and c Jun were also highly expressed in the endothelial cell cytoplasm and observed within the cell nucleus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The mRNA of CYP1A1 and 1A2 , c fos , and c jun and protein levels of c fos and c jun were analyzed in lungs using a real time reverse transcription polymerase chain reaction ( real time RT PCR ) assay and Western blot analysis , respectively . ^^^ Meanwhile , the mRNA and protein levels of c jun and c fos were increased significantly . ^^^ Nevertheless , exposure to B ( a ) P plus inhaled SO 2 increased the mRNA and protein levels of c jun and c fos in lungs compared with lungs exposed to SO 2 alone . ^^^ However , when B ( a ) P and SO 2 were given in the combinations , one might postulate that a synergistic effect on the expressions of c fos and c jun between SO 2 and B ( a ) P , which might be one of the possible mechanisms of combination effects between B ( a ) P and the air pollutants . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Small increases in mRNA levels encoding all AP 1 component proteins , except c fos , were also noted . ^^^ Following the addition of 1 nmol / L of 1 , 25D , the cellular content of each of these four proteins markedly increased in a sustained manner , whereas the increases in c fos , fra 1 , fra 2 , and jun D were minimal , if any . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Whole cell and nuclear extracts from lymphocytes were immunoblotted for GR , c fos , JNK and NF kappaB and nuclear aliquots were submitted to electrophoretic mobility shift assay for GR , AP 1 and NF kappaB . ^^^ Euthymics had normalized whole cell GR content ( 73 . 64 + / 5 . 95 % ) and GR DNA binding activity ( 76 . 82 + / 7 . 29 % ) but higher nuclear GR content ( 86 . 89+ / 3 . 96 % , P < 0 . 01 ) than controls ; ( b ) nuclear c fos content and AP 1 DNA binding were significantly lower in depressed patients than controls ( 80 . 49 + / 2 . 03 versus 84 . 82 + / 3 . 48 % , P < 0 . 05 and 78 . 46 + / 4 . 17 versus 84 . 80 + / 5 . 79 % , P < 0 . 05 , respectively ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The depletion of TIMP 1 and TIMP 2 from FCS affected remarkably the induction of c jun and c fos mRNAs , but not that of c ets 1 mRNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Further , in contrast to the JunD and Fra 2 components present in the AP 1 complex at this AP 1 site in UECs , c Fos was the major detectable AP 1 component in HCCCs . ^^^ Small interfering RNAs ( siRNAs ) against c Fos significantly suppressed AP 1 activity at the relevant AP 1 site , and led to a decrease in TGFbeta 1 secretion by the HCCCs . ^^^ Our results indicate for the first time that c Fos binding at the TGFbeta 1 promoter proximal AP 1 site in HCCCs is required for TGFbeta 1 production by the tumor cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we demonstrate that siRNAs that have been generated in vitro by recombinant human Dicer ( re hDicer ) significantly suppress not only the exogenous expression of a puromycin resistance gene but also the endogenous expression of H ras , c jun and c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Super shift / shift inhibition analysis demonstrated the presence of c Fos and c Jun protein families in the transcriptional complex bound to AP 1 sequences . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In LT 97 cells , COX 2 upregulated c fos expression and c jun content in nuclear extracts 1 . 7 and 1 . 2 fold , respectively , in a PG dependent way . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
At the beginning of the night , norepinephrine ( NE ) elicits a rapid and sustained phosphorylation of CREB into pCREB and a transient synthesis of the immediate early gene products c FOS and c JUN that peak 3 h after dark onset . c FOS synthesis requires both pCREB and the pERK1 / 2 pathways . ^^^ Interestingly , injection of the protein synthesis inhibitor cycloheximide before , but not after , the c FOS / c JUN peak markedly reduces Aanat mRNA levels . ^^^ This finding suggests that the c FOS / c JUN dimer is required for transcriptional activation of the Aanat gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
At the end of observation , vaccinated SHRs manifested lower BP , decreased cardiac hypertrophy and attenuation of kidney injuries . mRNA levels of c fos and c jun in heart and kidneys were decreased in vaccinated SHRs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift , supershift , and chromatin immunoprecipitation assays showed increased binding of c Fos and c Jun to the 72 and 181 AP 1 sites during H . pylori infection . ^^^ The combined induction of c fos , c jun , and polyoma enhancing activator 3 ( pea 3 ) by H . pylori caused maximal increase in MMP 1 expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Results of in situ hybridization show that the level of c fos and c jun expression is significantly higher 3 . 5 h after exposure to pheromones of adult males . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment with TGF beta in mast cells resulted in the differential gene induction of the AP 1 components , i . e . , transient induction of c fos but not of c jun and junB . ^^^ Our results suggest that TGF beta stimulates mmcp 7 transcription through the Smad 3 Smad4 pathway as well as c fos induction , and that the AP 1 components distinctly related with the TGF beta pathway . . ^^^ Expression of c fos further enhanced Smad 3 and Smad 4 induced transcription of mmcp 7 , whereas c jun expression inhibited the transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of electro acupuncture on the expression of c jun and c fos in spared dorsal root ganglion and associated spinal laminae following removal of adjacent dorsal root ganglia in cats . ^^^ This study evaluated the plastic changes of c jun and c fos in the right sixth lumbar dorsal root ganglion ( L 6 DRG ) , Rexed ' s lamina 2 in representative spinal segments L 3 , L 5 , and L 6 and in the nucleus dorsalis ( ND ) at L 3 segments after electro acupuncture ( EA ) in cats subjected to removal of L 1 L5 and L 7 S2 DRG . ^^^ Following dorsal root ganglionectomy , there was a significant increase in the density of c jun immunoreactivity in the neurons and glia in spinal lamina 2 and in the ND ; there was also marked elevation in the expression of c fos in ND . ^^^ In both cases there was no change in the c jun and c fos immunoreactivity in the DRG . ^^^ After EA in the operated animals , there was an up regulation in the expression of c jun in the L 6 DRG and the associated spinal lamina 2 ; however , increased c fos expression was detected only in the L 6 DRG . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We mimicked the action of environmental ultraviolet on skin and investigated the effects of UVB irradiated human keratinocytes HaCaT and IL 1alpha on mitogen activated protein ( MAP ) kinase activation , c Jun and c Fos ( AP 1 is composed of Jun and Fos proteins ) mRNA expression and MMP 1 production in UVA irradiated dermal fibroblasts . ^^^ MAP kinase activity expression in fibroblasts was detected by Western blot . c Jun and c Fos mRNA expressions were determined by reverse transcriptional polymerase chain reaction ( RT PCR ) ; MMP 1 production in culture medium was detected by enzyme linked immunosorbent assay ( ELISA ) . ^^^ IL 1alpha increased MAP kinase activity and c Jun mRNA expression , IL 1alpha also increased c Fos mRNA expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^ The latter two were designed to specifically target c Fos or c Jun . ^^^ Thermal melts of all 45 possible dimeric interactions have been surveyed , with the FosW c Jun complex displaying a melting temperature ( T ( m ) ) of 63 degrees C , compared to only 16 degrees C for wild type c Fos c Jun interaction . ^^^ However the T ( m ) far exceeds wild type c Fos c Jun and averaged JunW and c Fos , indicating a preference over either homodimer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , inhibitions of ERK and JNK by 2 ' , 4 ' , 7 THF resulted in the decrease of c Fos expression and c Jun phosphorylation / expression induced by UV , respectively , which led to the inhibition of UV induced AP 1 DNA binding activity . ^^^ In conclusion , our results demonstrate that 2 ' , 4 ' , 7 THF can inhibit UV induced MMP 1 expression by inhibiting the MEK1 / ERK / c Fos and SEK1 / JNK / c Jun pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immediately following RF field exposure ( T = 6 h ) and 18 h post exposure ( T = 24 h ) , cell pellets were collected from each of the culture dishes and analyzed for transcript levels of proto oncogenes ( c jun , c myc and c fos ) and the stress related genes ( heat shock proteins ( HSP ) HSP 27 and HSP70B ) by quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ RESULTS : No significant effects were observed in mRNA expression of HSP 27 , HSP 70 , c jun , c myc or c fos between the sham and RF exposed groups , in either of the two cell lines . ^^^ However , the positive ( heat shock ) control group displayed a significant elevation in the expression of HSP 27 , HSP 70 , c fos and c jun in both cell lines at T = 6 and 24 h , relative to the sham and negative control groups . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
During Ag stimulation of T cells , the recognition of B 7 molecules by the CD 28 costimulatory receptor increases the level of c Fos , a component of the AP 1 transactivator known to bind the 5 ' Il 2 gene enhancer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It was not clear which style was more related with cell mechanotransduction . c fos is known to be a component of a transcription factor , activator protein 1 , which is induced by oxidative stress . ^^^ The regulatory pathways involved in the rapid response of the AP 1 transcription factor , c fos , to mechanical load in the human pulmonary epithelial cell line A 549 were investigated using a four point bending model . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ligation of CD 6 induced the transcriptional activation of reporter genes under the control of the c Fos serum responsive element and AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mechanistic studies showed that Dz 13 blocks cytokine inducible endothelial c Jun , E selectin , ICAM 1 , VCAM 1 and VE cadherin expression but has no effect on JAM 1 , PECAM 1 , p JNK 1 or c Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Abundance of c fos , c jun , interleukin ( IL ) 1beta , Toll like receptor ( TLR ) 2 , TLR 4 , and tumor necrosis factor ( TNF ) alpha message levels were measured by RNase protection assay . ^^^ Exposure to ozone for 4 h induced a c fos and c jun response in 4 ; 10 ; and 56 day old mice in a dose dependent manner , was localized to conducting and terminal airways , and also induced TLR 4 message abundance in 10 and 56 day old mice . ^^^ Exposure to LPS induced c fos and c jun 30 and 60 min postinhalation in 10 and 56 day old mice only . ^^^ Exposure to LPS followed by ozone increased message abundance of IL 1beta , TNFalpha , TLR 2 , TLR 4 , and c jun / c fos at 10 and 56 days , suggesting that combined exposures that induce cellular stresses can regulate gene expression by activating signaling pathways that operate through both transcription factors activator protein ( AP ) 1 and nuclear factor ( NF ) kappaB . ^^^ However , only c jun / c fos and TNFalpha were elevated in 4 day old mice after sequential exposures , suggesting that the early activation of the inflammatory response after sequential exposures may occur through a TLR independent pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
LPS stimulated both AP 1 ( c Fos , c Jun ) and NF kappaB ( p 50 and p 65 ) activation , but only inhibition of AP 1 attenuated LPS induced CXCR 6 expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Microglia derived IL 1beta consequently triggers transcriptional upregulation of immediate early genes such as c Jun , Egr 1 , and c Fos in the mixed glial cultures , and stimulates the upregulation of late response genes such as lipocalin in purified oligodendrocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : In Caco 2 cells , ASBT messenger RNA expression was reduced 65 % after interleukin 1beta treatment , while c fos and c jun were up regulated 2 fold . ^^^ Human ASBT promoter activity was enhanced by c jun and repressed by a dominant negative c jun , c fos , or a dominant negative c fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : We performed enumeration of total ( CD45+ ) leukocytes and cells expressing c fos and total and phosphorylated c jun and JNK in bronchial biopsy sections from 9 GC sensitive and 17 GC resistant asthmatic patients taken before and after oral prednisolone ( 40 mg / 1 . 72 m ( 2 ) body surface area daily for 14 days ) using specific antibodies , immunohistochemistry , and image analysis . ^^^ RESULTS : At baseline , mean total ( CD45+ ) mucosal leukocytes , total cells expressing phosphorylated c jun and JNK , and mean percentages of cells in which these molecules were phosphorylated were similar in both groups , whereas mean total numbers of c fos immunoreactive cells were increased in the GC resistant asthmatic subjects ( P = . 04 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Minutes after Ca2+ signal initiation , an increase in ERK1 / 2 and CREB phosphorylation and of mRNA for the early genes c fos and c jun was detected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The top list of genes displaying high degree and high betweennes , such as p 53 , c fos , c jun and c myc , is enriched with genes that are known as having tumor suppressor or proto oncogene properties , which supports the biological significance of the identified key topological elements . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the c Fos and c Jun , components of activator protein 1 ( AP 1 ) , which are known to regulate bcl 10 ( L ) gene transcription , were increased in response to EGF . ^^^ Pretreatment of the cells with PD 98059 , an inhibitor of MAP kinase kinase , inhibited the EGF induced c Fos and c Jun expression , AP 1 DNA binding , Bcl 10 ( L ) expression , and the resistance against ADR induced apoptosis , suggesting that EGF transmitted the antiapoptotic signal in such a way that it activated AP 1 via a MAP kinase signaling pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Phosphorylation of p 300 is triggered by phosphorylated AML 1 as well as by PU . 1 , c MYB , c JUN and c FOS , and is inhibited by dominant negative HIPK 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Pharmacological inhibition of EGFR tyrosine kinase significantly inhibited UVB mediated induction of ERK , p 38 , and JNK MAP kinases , and their effectors , transcription factors c Fos and c Jun . ^^^ In addition , UVB induced both c Fos and c Jun proteins in B82K+ cells , whereas neither were induced in B 82 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thereafter , rats were sacrificed ( N=3 6 / group ) at times 15 and 30 min and 1 , 2 , 6 , and 24 hr and the livers analyzed by Northern blot analyses for mRNA of the following immediate early proto oncogenes ( IEP genes ) : c fos , c jun , and c myc . ^^^ The results of the study revealed that within 15 min , c fos and c jun mRNA expression increased in colectomized rats , with peak expression occurring at 30 and 60 min , respectively . c myc mRNA expression was more delayed , with peak expression occurring at 6 hr post colectomy . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oxidative stress , assessed as the ratio of glutathione disulfide ( GSSG ) to reduced glutathione ( GSH ) , and AP 1 DNA binding activity ( c Fos and c Jun dependent DNA binding ) were measured in the maternal livers and embryos 0 . 5 , 3 , and 6 hr after treatment . ^^^ While c Jun DNA binding activity in embryos was not affected , c Fos DNA binding activity was elevated significantly 3 hr after BrdU exposure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription factors , c jun , c fos and cyclin AMP responsive element binding ( CREB ) protein , could markedly enhance the promoter activities . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of insulin like growth factor receptor ( IGF 1R ) , c Fos , and c Jun in uveal melanoma : an immunohistochemical study . ^^^ The immunoreactivity of insulin like growth factor receptor type 1 ( IGF 1R ) , c Fos , and c Jun by immunohistochemistry was studied in three groups of uveal melanomas and was correlated clinicopathologically . ^^^ In group C ( n = 6 ) , tumors with liver metastasis showed higher expressions of IGF 1R ( p = 0 . 0001 ) , c Fos ( p = 0 . 004 ) , and c Jun ( p = 0 . 018 ) compared with the tumors with no extension / extrascleral extension without liver metastasis ( groups A 45 and B 9 ) . ^^^ Further studies are required to elucidate the role of sequential upregulation of these proteins and the transcriptional activity of c Fos and c Jun in uveal melanomas with liver metastasis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We find that cyclin A and p34cdc2 expression is decreased by two to four fold in old fibroblasts , but that Fos expression and binding activity are reduced by as much as 95 % in old , as opposed to young cells , despite equivalent amounts of p105Rb and Jun proteins being expressed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun : oncogenic transcription factors . ^^^ The fos and jun proto oncogenes are members of the set of genes known as cellular immediate early genes . ^^^ Continuous overexpression of fos or jun causes transformation of fibroblasts . ^^^ Because of their ubiquitous expression it is believed that the target genes regulated by Fos and Jun are different in the many circumstances in which they are expressed . ^^^ These include formation of a large number of heterodimeric complexes , post translational modification by phosphorylation and a novel reduction / oxidation ( redox ) mechanism , presence of both positive and negative transcriptional domains and the ability of Fos and Jun to induce distinct bends in DNA structure . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A consideration of the role of the T antigens in the initiation of a mitogenic response of the host cell has to take into account the recent discovery that virus adsorption is sufficient to induce the synthesis of proteins which are known to appear early after quiescent cells are stimulated by the addition of serum , namely fos , jun , and myc ( J . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , cotreatment with RA results in a decrease of phorbol induced mRNA levels of fos and jun , and binding of nuclear proteins to an AP 1 oligonucleotide . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Basal expression of Fos , Fos related , Jun , and Krox 24 proteins in rat hippocampus . ^^^ The basal expression of the protein products of the inducible immediate early genes ( IEGs ) , Fos , Jun , and Krox 24 , was investigated in rat hippocampus using immunocytochemical visualization methods with antisera specific for Fos only , Fos and the Fos related antigens ( FRAs ) , the Jun family , and Krox 24 ( previously described as TIS 8 , egr 1 , NGF IA or zif 268 ) . ^^^ In the normal adult rat brain basal levels of Jun , Krox 24 and Fos related antigens but not Fos were seen within the hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CAT expression from pICP 10 cat was enhanced by co transfection with jun and fos encoding DNA , and the ICP 10 promoter complexed with in vitro synthesized jun protein . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun together with Fos effectively activated the collagenase promoter that contains a single TRE site . ^^^ However , not only was BZLF 1 unable to stimulate the collagenase promoter , but it also inhibited activation by Jun and Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Opposing actions of Fos and Jun on transcription of the phosphoenolpyruvate carboxykinase ( GTP ) gene . ^^^ Jun homodimers and Fos / Jun heterodimers bind to the gene for phosphoenolpyruvate carboxykinase ( GTP ) ( EC 4 . 1 . 1 . 32 ) ( PEPCK ) at three sites within the first 350 base pairs of the promoter . ^^^ Over expression of Jun in HepG 2 cells resulted in a 10 15 fold increase in the level of transcription of a chimeric PEPCK ( 490 to +73 ) CAT gene , while expression of Fos decreased transcription and blocked the induction of transcription from the PEPCK promoter by Jun . ^^^ The action of Fos and Jun on PEPCK gene transcription involved each of the Fos / Jun binding sites and was modulated by additional transcriptional regulatory elements within the PEPCK promoter . ^^^ The ability of Fos to inhibit PEPCK transcription was dependent upon P 3 ( 1 ) , a region of the promoter which does not bind Fos / Jun heterodimers , but does bind members of the C / EBP family of transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Involvement of FOS and JUN in the activation of visna virus gene expression in macrophages through an AP 1 site in the viral LTR . ^^^ In the present investigation , we examined the association of two DNA binding proteins , the proto oncogene proteins FOS and JUN , with this AP 1 site in the visna virus LTR . ^^^ Furthermore , the binding of cellular proteins from the U 937 nuclear extracts to this AP 1 site was significantly decreased in the presence of antibodies to JUN and FOS . ^^^ In vitro translated JUN protein also binds to this AP 1 sequence , and this binding is enhanced by the FOS protein . ^^^ These results indicate that JUN and FOS are directly involved in the differential regulation of visna virus gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of the transcription factors Fos and Jun was studied in rat brain after transection of the fornix fimbria ( FF ) using polyclonal antibodies to these proteins and immunocytochemical detection methods . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factor AP 1 which regulates expression of collagenase in response to various extracellular signals is a multimeric complex composed of members of the Jun and Fos families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report here an analysis of the interactions of transcription factors that are also the products of oncogenes : the erbA , jun and fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results identify an additional functional requirement for transformation by Fos proteins and have implications for the mechanism ( s ) of mitogenic signaling by the AP 1 transcription complex . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we demonstrate that the protein product of the ref 1 gene stimulates the DNA binding activity of Fos Jun heterodimers , Jun Jun homodimers and Hela cell AP 1 proteins as well as that of several other transcription factors including NF kappa B , Myb and members of the ATF / CREB family . ^^^ Redox activation of Fos Jun DNA binding activity is mediated by a DNA repair enzyme . ^^^ The DNA binding activity of Fos and Jun is regulated in vitro by a post translational mechanism involving reduction oxidation . ^^^ Redox regulation occurs through a conserved cysteine residue located in the DNA binding domain of Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Early response genes such as the jun and fos gene family members encode such nuclear transcription factors which are expressed in lung cancer cells and primary bronchial epithelial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The number of glial cells labelled by c JUN and JUN D did not change , and glial cells were not labelled by FOS and KROX 24 proteins following sciatic nerve transection . ^^^ Expression of CREB , JUN , FOS and KROX 24 proteins was investigated in glial cells of the lumbar spinal cord . ^^^ These findings demonstrate that proliferation and differentiation of glial cells in vivo can occur in absence of JUN , FOS and KROX proteins . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because agonist induced modulations in the rate of synthesis of tPA and ET have been associated with the Fos and Jun protein families , it seems reasonable to propose that genetic expression in shear stress or mechanical strain stimulated endothelial cells is also regulated by selective induction of fos and jun gene products . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The purpose of the current study was to determine whether TGF beta 1 could regulate the expression of both the jun and fos genes that encode transcriptional regulatory proteins that constitute the AP 1 complex , and to determine whether expression of these genes may be coordinated with the decrease in albumin mRNA . ^^^ Transforming growth factor ( TGF ) beta stimulates hepatic jun B and fos B proto oncogenes and decreases albumin mRNA . ^^^ Transforming growth factor beta 1 increased the levels of both jun B and fos B mRNA by 60 minutes after treatment of mouse hepatoma ( BWTG 3 ) cells . ^^^ The tumor promoting phorbol ester ( phorbol 12 myristate 13 acetate [ PMA ] ) , known to induce jun and fos gene expression , caused increases in jun B and fos B that preceded the decrease in albumin mRNA levels at 24 hours . ^^^ These observations are consistent with our hypothesis that jun B and fos B induction may participate in downregulation of albumin synthesis as well as other hepatic responses to TGF beta . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Glucocorticoids modulate the transcription of genes in association with other transcription factors such as Fos , Jun , CREB , These combinatorial associations differing according to the differentiation and / or activation state of the cell may therefore produce a fine tuning of the induction or repression of genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 ( Fos Jun ) regulation by IP 1 : effect of signal transduction pathways and cell growth . ^^^ Transcription factor AP 1 is constituted by the various products of the fos and jun proto oncogene family members , which associate as dimers to bind with variable efficiency to 12 O tetradecanoyl phorbol 13 acetate ( TPA ) responsive promoter elements ( TREs ) . ^^^ AP 1 ( Fos Jun ) regulation by IP 1 : effect of signal transduction pathways and cell growth . ^^^ We conclude that IP 1 regulation has a pivotal role in the final modulation of Fos Jun by signal transduction pathways . . ^^^ Transcription factor AP 1 is constituted by the various products of the fos and jun proto oncogene family members , which associate as dimers to bind with variable efficiency to 12 O tetradecanoyl phorbol 13 acetate ( TPA ) responsive promoter elements ( TREs ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of fos and jun during T cell activation was accompanied by increased specific binding of JunB , FosB , and fos related antigen containing complexes to the TPA responsive element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The amino acid sequences of subunit 9 of plant mitochondrial ATP synthase contain a leucine motif which differs from the leucine repeat earlier detected within the composition of proteinaceous products of Myc , Fos , and Jun proto oncogens . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In both tissue biopsies and derivative cell lines , the proto oncogenes junB and c jun are induced in the latter two stages , in contrast to junD and fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These two regions are also required for tyrosine phosphorylation of an 85 kDa cellular protein ( p 85 ) and the accumulation of fos and jun mRNAs . ^^^ This observation suggests also that the activation of a receptor associated tyrosine kinase in response to IL 2 stimulation is primarily responsible for subsequent activation of the pathway through Ras to Fos and Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PDGF increases the expression of Fos and Jun in newly formed oligodendrocytes that have become resistant to the mitogenic effect of PDGF . ^^^ Here we show that PDGF increases the expression of the Fos and Jun nuclear proteins in newly formed oligodendrocytes in vitro , suggesting that at least one intracellular signalling pathway to the nucleus is activated by PDGF in these cells even though they do not synthesize DNA in response to PDGF . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , the H3 . 2 specific complex exhibits different reactivity toward the Jun and Fos specific antibodies as compared to complexes formed with a collagenase AP 1 element . ^^^ Antibodies specific to the different members of the Jun and Fos family of transcription factors show that , in gel retardation assays , a Jun like factor is a component of the H3 . 2 specific complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure of mammalian cells to DNA damaging agents induces the ultraviolet ( UV ) response , involving transcription factor AP 1 , composed of Jun and Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and jun heterodimers activate the transcription of genes containing an AP 1 site . ^^^ The activity of Fos and Jun proteins is regulated by post translational modification . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Tax protein ( p40tax ) of HTLV 1 activates in trans its own transcriptional enhancer in the long terminal repeat and also those in some cellular genes such as interleukin 2 receptor alpha , granulocyte macrophage colony stimulating factor , Fos , Jun and MHC class 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Some members of the Ets family , Ets 1 and Ets 2 , cooperate in transcription with the AP 1 transcription factor , the product of the proto oncogene families , fos and jun , while others , Elk 1 and SAP 1 , form ternary complexes with the serum response factor ( SRF ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Jun and Fos oncoproteins belong to the AP 1 family of transcriptional activators and are believed to induce cellular transformation by inappropriately activating genes involved in cell replication . ^^^ GCN 4 induces transcriptional activation through AP 1 sites but , unlike Jun and Fos , fails to induce cellular transformation , in cooperation with Ha ras . ^^^ Jun GCN 4 and Fos GCN 4 homodimers independently induce cellular transformation indicating that the amino terminal regions of Jun and Fos each contain regulatory functions that are required for oncogenesis but are distinct from generic transcriptional activation domains . ^^^ In addition , these observations have implications for the nature of the oncogenically relevant target genes that respond to Jun and Fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun form a tight heterodimeric complex that activates transcription by AP 1 sites . ^^^ Conserved motifs in Fos and Jun define a new class of activation domain . ^^^ We have recognized that two adjacent regions of the Jun A 1 activation domain are conserved in the Fos protein , and we refer to these two homologous regions as homology box 1 ( HOB 1 ) and homology box 2 ( HOB 2 ) . ^^^ Using GAL 4 chimeras , we show that the HOB1 / HOB2 region of Fos and Jun is an independent activation domain in which HOB 1 and HOB 2 act cooperatively to activate transcription . ^^^ This cooperativity is retained after the replacement of Fos HOB 1 or HOB 2 with the equivalent domain of Jun or when duplicated HOB1 / HOB1 and HOB2 / HOB2 combinations are generated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of mRNAs for nuclear oncogenes such as MYC , FOS and JUN was decreased by TAPP Br after treatment for 3 h and the effect continued for 48 h . mRNA expression of epidermal growth factor receptor , transforming growth factor beta and type 4 collagenase was suppressed at 48 h after the initiation of TAPP Br treatment , suggesting an indirect action of TAPP Br . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To gain understanding of the early genetic response of F MELC to the dimethyl sulfoxide ( DMSO ) inducer of F MELC differentiation , we have investigated by Northern blot analysis the expression of fos and jun family genes that encode components of the transcription factor AP 1 complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two heterodimer forming `` zipper ' ' peptides derived from the Fos and Jun proteins were respectively linked to the Fab ' portions of two different mAb by gene fusion . ^^^ Anti Tac Fab ' Jun and anti CD 3 Fab ' Fos were expressed individually as F ( ab ' zipper ) 2 homodimers in the mouse myeloma cell line Sp2 / 0 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear factor of activated T cells contains Fos and Jun . ^^^ We show that the inducible nuclear form of NF AT contains Fos and Jun proteins . ^^^ On the basis of binding , reconstitution and cotransfection experiments , we propose that activation of NF AT occurs in at least two stages : a CsA sensitive stage involving modification and / or translocation of the pre existing NF AT complex , and a CsA insensitive stage involving the addition of newly synthesized Fos or Fos / Jun proteins to the pre existing complex . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although it is not excluded , that also in the case of overlapping DNA binding elements protein protein interaction might in fact be responsible for repression instead of substitution , the two situations can be clearly distinguished by specific mutants in the glucocorticoid receptor and in Jun and Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun form a heterodimeric complex that regulates gene transcription by binding to the activator protein 1 ( AP 1 ) DNA sequence motif . ^^^ Although Ref 1 does not bind to the AP 1 site in association with Fos and Jun , it partially copurifies with a subset of AP 1 proteins . ^^^ Purified Ref 1 protein stimulates AP 1 DNA binding activity through the conserved Cys residues in Fos and Jun , but it does not alter the DNA binding specificity of Fos and Jun . ^^^ Previously , we demonstrated that the DNA binding activity of Fos and Jun is regulated in vitro by a novel redox ( reduction oxidation ) mechanism . ^^^ Reduction of a conserved cysteine ( cys ) residue in the DNA binding domains of Fos and Jun by chemical reducing agents or by a nuclear redox factor stimulates DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of jun and fos gene family members , which make up the AP 1 complex , can be stimulated by serum and a number of growth factors , including EGF , and by TPA . ^^^ Therefore , the possibility that differential expression of one or more forms of jun or fos contributes to the differential AP 1 activity was considered . ^^^ The data presented here demonstrate both similarities and differences in the basal and TPA or EGF induced levels of fos and jun family members between P+ and P cells . ^^^ The most striking observation was that the overall TPA and EGF induced levels of jun but not fos expression were higher in P+ cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inductions of jun and fos transcripts in the uterus by estradiol exhibit similar dose response curves ( maximum responses at 4 micrograms / kg ) . ^^^ In vivo treatment with the phorbol ester TPA rapidly elevates uterine levels of fos , jun , and myc transcripts , indicating that expression of these protooncogenes is under non estrogenic as well as estrogenic regulation in this target tissue . ^^^ These results suggest that multiple members of the jun and fos protooncogene families may play a role in amplifying the uterine response to estrogens . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of fos , jun , myc and ets oncogene RNA in mos induced hyperplastic Harderian glands shows that there are no consistent changes in the level of expression of these oncogenes , suggesting that mos acts via a mechanism other than by increasing the expression of these genes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This result , taken together with the repression of transformation by the leucine zipper deficient mutants L 345 and J / R510s , indicates that the interaction of Fos with proteins other than Jun is necessary for transformation . ^^^ This suggests that their inhibitory effect on transformation may at least in part be the result of the squelching of proteins other than Jun family members that are required for Fos mediated transactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among these marker genes , keratin 18 , has been shown to contain an AP 1 binding site , TGA ( C / G ) TCA , which is essential for high level , differentiation dependent expression and which is transactivated by Jun and Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cellular transition from the resting state to DNA synthesis involves master switches genes encoding transcriptional factors ( e . g . , fos , jun , and egr genes ) , whose targets remain to be fully characterized . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To identify proteins that interact with Jun or Fos we have used the protein interaction cloning system developed by S . ^^^ Several transformants exhibiting GAL 4 activity were identified and shown to harbor plasmids encoding polypeptides predicted to form coiled coil structures with Jun and / or Fos . ^^^ The tropomyosin polypeptides were found to interact in the yeast assay system with the bZIP region of Jun but not with the bZIP region of Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The basic domain of ZEBRA is homologous to the Fos / Jun oncogene family , and both proteins bind the canonical AP 1 site ( TGAGTCA ) . ^^^ Conversely , the Fos GCN 4 chimera recognizes only the Z AP 1 octamer . ^^^ Additionally , we have found that flanking sequences influence binding of Fos GCN 4 to a degenerate AP 1 site ( TGAGCAA ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Characterisation of functional inhibition of the glucocorticoid receptor by Fos / Jun . ^^^ We have studied the effects of Fos and Fos / Jun on glucocorticoid induction of hormone sensitive gene expression . ^^^ In NIH3T3 cells overexpression of Fos or Fos / Jun by transfection of pSV 2 fos and pSV 2 jun inhibited glucocorticoid dependent expression of MMTV LTR CAT . ^^^ It was established that the C / D domain of the receptor was a sufficient target for inhibition by Fos and Fos / Jun . ^^^ When present simultaneously in the cell nucleus Fos and Jun were shown to form a specific and stable protein / protein complex with the glucocorticoid receptor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Results of DNase 1 footprint protection and gel retardation assays demonstrated that proteins in extracts of HeLa and BHK 21 cells as well as bacterially expressed Jun and Fos proteins bind to these AP 1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Muscle specific expression from the 28 bp MRE and the 2 . 3 kb skeletal actin promoter was trans repressed by the Fos and Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Platelet activating factor and polyunsaturated fatty acids in cerebral ischemia or convulsions : intracellular PAF binding sites and activation of a fos / jun / AP 1 transcriptional signaling system . ^^^ PAF activates the transcription of the immediate early genes fos and jun , whose gene products are regulators of the transcription of other genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , Fos and Jun expression were only very slightly increased in a few scattered neurons in the dopamine denervated striatum . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the one hand , enhanced intracellular calcium mobilization may play a role in arterial tone and contraction whereas , on the other hand , enhanced activation of proto oncogenes , myc , fos , and jun , may be involved in the mechanisms of arteriosclerosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the neu oncogene but not the protooncogene in NIH 3T3 cells was associated with enhanced levels of the jun and fos oncoproteins and loss of serum growth factor induction of immediate early mRNA responses . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of jun and fos gene expression in human monocytes by the macrophage colony stimulating factor . ^^^ The present studies have examined the effects of M CSF on potential signaling pathways involving expression of the jun and fos early response genes . ^^^ Taken together , the results indicate that M CSF treatment is associated with differential activation of multiple members of the jun / fos family and that expression of these genes could contribute to nuclear signaling mechanisms that regulate a specific program of monocyte differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The contribution of expression of human cytomegalovirus ( HCMV ) immediate early ( IE ) genes to the rapid and transient increase in cellular ( c ) oncogene ( fos , jun , myc ) transcription following HCMV infection was investigated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
CNE 323 transferred moderate transforming activity when introduced into JB 6 P+ cells and showed no homology to Ha , Ki , or N ras genes ; human promotion sensitivity genes ; src , myb , jun , myc , fos , raf , or int 2 oncogenes ; or epidermal growth factor receptor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous studies in PC 12 pheochromocytoma cells indicate that lithium has a dramatic augmenting effect on expression of the fos proto oncogene , a component of the AP 1 transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results indicate that both adapted and unadapted strains of HCMV induce substantial increases in c oncogene RNA levels for fos , jun , and myc measured by Northern blot hybridization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 is constituted by the various products of the jun and fos gene family members . ^^^ AP 1 is constituted by the various products of the jun and fos gene family members . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of the protein products of the immediate early genes ( IEGs ) , members of the fos , jun and krox families ( Jun , Fos , and Krox , resp . ) was investigated in the spinal cord and sensory ganglia ( DRG ) of normal rats ; and following transection of , block of axonal transport in , or electrical stimulation of their peripheral axons . ^^^ The nuclei of many moto and DRG neurons showed a faint basal immunoreactivity ( IR ) for Jun proteins , but not for Fos or Krox proteins . ^^^ In contrast , Jun , Fos and Krox proteins were all induced transynaptically in spinal dorsal horn neurons following electrical stimulation of the C fibers in the afferent nerves . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Levels of Fos protein induced through diverse signal transduction pathways , the amount of AP 1 DNA binding activity in vitro , and the activity of an AP 1 dependent reporter gene in vivo are substantially decreased as fibroblasts age . ^^^ Moreover , the composition of the AP 1 complex changes , so that old cells produce predominantly Jun Jun homodimers instead of Fos Jun heterodimers . ^^^ Changes in AP 1 activity may be due in part to changes in posttranslational modification of Fos protein that impair its ability to form active DNA binding heterodimers with Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Its C terminal region contains a basic motif and a leucine zipper domain similar to the DNA binding proteins of the jun and fos oncoprotein family , and it shows a strong similarity to the product of an avian retroviral oncogene , 5 maf . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Sequential expression of JUN B , JUN D and FOS B proteins in rat spinal neurons : cascade of transcriptional operations during nociception . ^^^ Expression of the immediate early gene encoded proteins JUN B , JUN D and FOS B was investigated by immunocytochemistry in rat L 5 spinal cord up to 24 h following stimulation of hind limb somatosensory nociceptors by noxious heat or injection of formalin . ^^^ The results are discussed in respect to their meaning for transcriptional operations of JUN and FOS proteins . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we demonstrate that the expression of jun and fos gene family members is induced with variable kinetics during 12 O tetradecanoylphorbol 13 acetate induced differentiation , with c jun expression best paralleling differentiation . ^^^ The role of jun and fos gene family members in 12 O tetradecanoylphorbol 13 acetate induced hemopoietic differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An empirical Gibbs free energy , delta G , function which incorporates hydrophobic force , electrostatic interactions , and conformational entropy loss as the major intermolecular interactions was used to estimate the delta G of dimer formation in fos , jun , and GCN 4 zipper sequences . ^^^ The preferential stability of fos jun heterodimer over the jun jun and fos fos homodimers is primarily due to the side chains Asp b 1 , Glu g 1 , Asp b 2 , Glu e 2 , Glu g 2 , Glu g 3 , and Lys a 5 of the fos helix , and Arg c 1 , Lys g 1 , Lys b 2 , Lys e 2 , Arg e 4 , and Glu g 4 of the jun helix . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , GalTase gene expression is regulated in a manner that resembles other `` early response ' ' genes such as jun and fos upon reentry into the cell cycle from quiescence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cloning and characterization of transcription factors has revealed that these factors coordinately regulate the transcription of specific genetic programs ; for example , a number of phorbol ester induced genes are activated by binding of the transcription factors Fos and Jun to specific DNA sequences . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrate that CREB will form heterodimers with ATF 1 , but not ATF 2 , Jun , Fos , or C / EBP whereas , ATF 2 will form heterodimers with Jun and Fos , but not with C / EBP or ATF 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , co expression of antisense fos ( here referred to as sof ) inhibited the down regulatory effect of Fos on glucocorticoid induced gene expression . 5 mos expression in NIH3T3 cells induces fos mRNA and functional fos product ( Fos ) as reflected by its ability to induce expression of a transiently transfected AP 1 dependent reporter plasmid . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We examined the expression of the nuclear `` early response ' ' genes jun and fos and the `` tumor suppressor ' ' retinoblastoma ( Rb ) gene , as well as genes involved in invasion ( major excreted protein [ MEP ] , tissue inhibitor of metalloproteinases [ TIMP ] ) , and cell adhesion ( secreted phosphoprotein 1 [ SPP 1 ; also known as osteopontin ] ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Molecular cloning and expression of a protein tyrosine phosphatase showing homology with transcription factors Fos and Jun . ^^^ The non catalytic region of this PTPase located at the carboxy terminus shows homology with the basic domains of transcription factors Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A summary of what is known about some of these regulatory oncogenes ( fos , jun , myc , and Rb 1 ) and where they might function in the progression of a cell from G 0 to G 1 and G 1 to S is presented . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Our findings indicate that a set of potentially interacting C / EBP like proteins exists , whose complexity is comparable to that of other bZIP protein subfamilies such as Jun , Fos , and ATF / CREB . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos and Jun proteins , which are components of the transcription factor AP 1 , associate through the interaction of their so called leucine zipper domains and bind strongly and specifically to DNA at phorbol ester responsive elements . ^^^ Jun also homodimerizes and binds the same element whereas Fos seems to have no specific affinity for DNA . ^^^ We show that a single amino acid change in the leucine zipper of Fos is sufficient to allow a truncated Fos protein to homodimerize and thus form a complex with DNA , even in the absence of Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulated and unstimulated extracts with high and low AP 1 DNA binding activities contain the same levels of proteins reactive with antisera against Jun and Fos , proteins which are shown to be involved in the AP 1 / DNA complexes detected in vitro . ^^^ These observations , taken together , suggest that the efficiency with which pre existing Fos and Jun proteins can bind an AP 1 target sequence in vitro can be controlled by a nuclear activity which is sensitive to oxidation / reduction and that this control mechanism is specific for AP 1 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 consists of the products of the fos and jun oncogenes , which associate as dimers to bind TPA responsive promoter elements ( TRE ) efficiently . ^^^ IP 1 specifically blocks DNA binding of AP 1 from nuclear extracts and of in vitro synthesized Fos / Jun proteins . ^^^ IP 1 : a dominant inhibitor of Fos / Jun whose activity is modulated by phosphorylation . ^^^ AP 1 consists of the products of the fos and jun oncogenes , which associate as dimers to bind TPA responsive promoter elements ( TRE ) efficiently . ^^^ Competition experiments with synthetic peptides suggest that IP 1 could interact with Fos and / or Jun leucine zippers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We analyzed mRNA expression for different classes of immediate early genes ( JUN , EGR 1 , and FOS ) after cellular 10 irradiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Non leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization . ^^^ Various transcription factors , including C / EBP , GCN 4 and members of the Fos , Jun and Myc families have been shown to form highly specific complexes via alpha helical structures referred to as leucine zippers . ^^^ In this study , we show that amino acids , which are located in positions a , e , and g are instrumental in the formation of Fos / Jun heterodimers , presumably by establishing intermolecular electrostatic and hydrophobic interactions . ^^^ These residues are highly conserved in proteins of the Fos or Jun families but completely different between Fos and Jun , suggesting that these residues determine the specificity of interaction . ^^^ This conclusion is supported by the observation that the substitution of amino acids in position a or g in Fos with the corresponding Jun amino acids facilitates the association of two Fos leucine repeats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both , fosB and 5 fos transformed cells show increased expression of a number of endogenous genes , including c jun , transin , alpha 1 ( 3 ) collagen and tissue plasminogen activator . ^^^ Transactivation by FosB and 5 fos of the c jun and alpha 1 ( 3 ) collagen gene promoters and of a 3 10 TRE tk chimeric promoter could be shown in transient CAT assays . 5 Fos , but not FosB transformed cells , also show elevated levels of urokinase and plasminogen activator inhibitor mRNAs , pointing to potential differences in the gene regulatory properties of the two Fos family members . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro DNA binding activity of Fos / Jun and BZLF 1 but not C / EBP is affected by redox changes . ^^^ The bacterially expressed DNA binding domains of Fos / Jun and BZLF 1 are unable to bind DNA under non reducing conditions whereas binding of the C / EBP DNA binding domain is unaffected . ^^^ Sensitivity to redox state is due to the presence of a conserved cysteine residue in the basic DNA binding motif of Fos , Jun and BZLF 1 but not C / EBP . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These data suggest that the IL 1 beta R G mutein triggers an incomplete or defective signal transduction cascade and demonstrate that fibroblast fos and jun expression is not necessarily accompanied by increased transcription of genes containing the AP 1 binding site . ^^^ An interleukin 1 beta point mutant demonstrates that jun / fos expression is not sufficient for fibroblast metalloproteinase expression . ^^^ Although both IL 1 beta and the IL 1 beta R G mutein stimulate transcription of fibroblast immediate early ( fos and jun ) and early ( IL 1 beta and IL 6 ) genes , the IL 1 beta R G mutein , in contrast to the wild type IL 1 beta protein , induces minimal or no transcription of late genes such as procollagenase and prostromelysin . ^^^ The effect of the naturally occurring IL 1 receptor antagonist protein ( IL 1ra ) on fibroblast transcription is distinct from that of the IL 1 beta R G mutein , for the IL 1ra fails to stimulate not only late ( procollagenase and prostromelysin ) but also immediate early ( fos and jun ) gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Amino acid substitutions in this domain of Fos which impair DNA binding also destroy the transforming potential of Fos , suggesting that the interaction of Fos Jun complexes with TREs may be a crucial part of Fos induced transformation . ^^^ This hypothesis is further strengthened by our observation that Fos and Jun can cooperate in the induction of transformation . ^^^ We show that a Fos protein which contains a Jun leucine zipper and is thus capable of dimerization is still dependent on the presence of exogenous Jun to induce transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of jun transformation by a mutated fos gene : design of an anti oncogene . ^^^ The protein products of the fos and jun oncogenes ( Fos and Jun ) function as transcriptional regulators in the form of homo or heterodimeric complexes that bind to DNA . ^^^ Although Fos participates exclusively in heterodimeric complexes , Jun can function either as a homodimer that has a low apparent affinity for DNA or as a more stable heterodimer with Fos that has a higher apparent affinity for DNA . ^^^ We have used these properties of Fos and Jun to design a mutated fos gene , lacking a functional DNA binding domain ( supfos 1 ) , that suppresses the transforming activity of jun in trans . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By footprinting and gel retardation analysis we found that it contained two binding sites for transcription factor AP 1 , encoded by the fos and jun proto oncogene families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Studies performed over the last three years on the jun and fos oncogenes have taught us a great deal about how these cancer causing genes function in the nucleus . ^^^ The products of the jun and fos protooncogenes appear to enhance the transcription of specific genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Incubation with TNF in vitro has been shown to increase viability , DNA synthesis and the expression of the protooncogenes myc , fos and jun in the tumour cells from these patients . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNA bending by Fos and Jun : the flexible hinge model . ^^^ This technique has been applied to the analysis of DNA bending by the transcription regulatory proteins Fos and Jun . ^^^ Complexes that contained different combinations of full length and truncated Fos and Jun induced DNA bends of different magnitudes and orientations . ^^^ This information was used to visualize the consequences of DNA bending by Fos and Jun for the structures of Fos Jun DNA and Jun DNA complexes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to evaluate the role of proto oncogenes in the regulation of growth of bronchial epithelial cells , we studied steady state levels of fos , jun , and myc transcripts in response to fetal calf serum , bovine pituitary extract , and insulin . ^^^ We observed rapid but transient increases of fos , jun , and myc expression in association with such growth stimulation . ^^^ Other `` growth factors ' ' ( epidermal growth factor , hydrocortisone , epinephrine , triiodothyronine , and transferrin ) were also studied and did not affect either cell growth or expression of fos , jun , or myc . ^^^ TGF beta 1 consistently inhibited the growth induced by fetal calf serum , bovine pituitary extract , or insulin and , interestingly , reduced proto oncogene myc mRNA level without altering that of fos and jun . ^^^ In conclusion , proto oncogenes fos , jun , and myc appear to play a role in the regulation of growth response in bovine bronchial epithelial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Surprisingly , two thirds of these genes are also expressed in BALB / c 3T3 cells , but only 10 were identified in previous studies of 3T3 cells , and of these , 6 include well known genes like jun and fos , and only 4 are novel . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect on the gene for the alpha subunit of chorionic gonadotropin is due to DNA binding competition between the receptor and the protein mediating cAMP induction , whereas repression of the collagenase gene involves an interaction of the receptor with components of the AP 1 complex , Jun and Fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of various protooncogenes ( myc , Ki ras , Ha ras , erbB , fms , sis , jun and fos ) and a gene implicated in multidrug resistance ( mdr 1 ) was investigated in cell sublines , isolated from a rat rhabdomyosarcoma cell line , and in the corresponding tumors induced by injection of these cells into syngeneic rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The series of enzymatic reactions set in motion by indirect transduction systems require strict regulation systems , the diversity and the complexity of which has been perceived in studies on jun and fos gene families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DBP belongs to a family of related transcription factors including Fos , Jun , CREB , and C / EBP , which share a conserved basic domain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fos protein made in insect cells manifested most of the characteristics of mammalian fos protein , which include ( 1 ) 55 kilodalton size , ( 2 ) nuclear localization , ( 3 ) phosphoesterification at serine residues , ( 4 ) identical 35S tryptic peptide maps , ( 5 ) ability to make heterodimers with the nuclear jun oncoprotein , and ( 6 ) cooperation with the jun protein to bind to a 12 O tetradecanoyl phorbol 13 acetate responsive element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein products of the fos and jun protooncogenes interact cooperatively in the form of a heterodimer with the activator protein 1 ( AP 1 ) regulatory element . ^^^ Moreover , UV crosslinking studies demonstrated that Fos and Jun contact DNA directly and that both proteins interacted equivalently with either strand of the AP 1 binding site . . ^^^ Expression and purification of the leucine zipper and DNA binding domains of Fos and Jun : both Fos and Jun contact DNA directly . ^^^ To characterize the properties of these proteins , we have expressed polypeptides comprised of the dimerization and DNA binding domains of Fos and Jun in Escherichia coli . ^^^ The mini Fos ( wbFos ) and the mini Jun ( wbJun ) proteins were purified to apparent homogeneity by using a nickel affinity chromatography procedure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fos / jun heterodimer binds to and activates transcription from TPA responsive promoter elements ( TGACTCA ) , which represent one final target of the protein kinase C pathway . ^^^ We show that jun efficiently trans activates CRE sequences and that fos and jun efficiently bind and cooperate in activating CRE promoter elements . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both Jun and Fos contribute to transcription activation by the heterodimer . ^^^ The addition of Fos and the formation of Jun Fos heterodimers strongly increases the transactivation level . ^^^ Jun mutants that are inactive alone gain partial or full activity in the presence of Fos . ^^^ These results show that in Jun Fos heterodimers both the N terminal part of Jun and the C terminal part of Fos contribute to transactivation with a more pronounced role for the latter . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and Fos nuclear oncoproteins form a complex that regulates transcription from promoters containing activator protein AP 1 binding sites . ^^^ Trans dominant negative mutants of Fos and Jun . ^^^ Jun and Fos nuclear oncoproteins form a complex that regulates transcription from promoters containing activator protein AP 1 binding sites . ^^^ The leucine zipper and basic region domains of both Fos and Jun are necessary for formation of the heterodimer that binds to DNA . ^^^ Reciprocal mutations in the basic region of Fos or Jun can influence the binding of the heterodimer to DNA , implying a symmetrical binding site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recently , AP 1 preparations from HeLa cells were shown to contain a product of the c JUN protooncogene ( Jun / AP 1 ) which forms a tight complex with the Fos protein . ^^^ In this paper , we examine the role of the Fos protein in the DNA binding activity of the AP 1 complex . ^^^ The site of Fos interaction is within the DNA binding domain of Jun / AP 1 , and anti Fos antibodies interfere with the binding of affinity purified AP 1 to DNA . ^^^ These results suggest that , by associating with Jun / AP 1 , Fos is responsible for the formation of a multimeric protein complex that has greater affinity for the target sequence than does Jun / AP 1 alone . . ^^^ DNA binding activity of Jun is increased through its interaction with Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Additionally , the potential interaction of fos and jun proteins with the GST pi promoter was examined by co transfection of GST cat constructs with jun and fos expression vectors in F 9 cells . ^^^ These data suggest that the putative TRE sequence in GST pi is unresponsive both to phorbol esters and to these particular transcriptional activating factors of the fos and jun family . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two nuclear oncoproteins , fos and jun ( AP 1 ) , cooperate in forming a very stable heterodimeric complex that binds to the AP 1 site on DNA with high affinity . ^^^ The ' leucine zipper ' domain of both fos and jun is necessary for the formation of this heterodimer . ^^^ However , results from mutagenesis of the first leucine of the heptad repeat in either fos or jun basic regions and alteration of the spacing between the basic and leucine zipper domains indicate that the basic region of fos plays a crucial role in determining the DNA binding affinity of the transcriptional complex . ^^^ Mutations of the basic amino acids in fos protein prevent binding to the tumour promoter response element ( TRE ) in the presence of wild type jun protein . ^^^ Thus fos protein appears to be dominant in jun fos binding to DNA , even though fos alone can not bind to TRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Drosophila Fos related AP 1 protein is a developmentally regulated transcription factor . ^^^ Drosophila AP 1 consists of two proteins ( dFRA and dJRA ) that have functional and structural properties in common with mammalian Fos and Jun proto oncogene products . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Enhancer activity appears to be mediated by the binding of a complex of proteins from the jun and fos families to tandem AP 1 consensus sequences . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , we demonstrate that GR is capable of inhibiting , in a hormone dependent fashion , Fos mediated transactivation of AP 1 dependent transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Induction of early response genes ( fos , jun , and zif 268 ) by NGF and FGF but not by TPA was also inhibited by high levels of p 21 ( Asn 17 ) Ha ras . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Included among the targets of PKC is activation of fos protooncogene expression , a well established component of the AP 1 transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The activation of the heme oxygenase ( HO ) , fos , and AP 1 genes was determined at intervals after treatment of M 1 cells ( derived from mouse myeloleukemia ) with heme or 12 O tetradecanoylphorbol 13 acetate ( TPA ) . ^^^ Moreover , the sequential activation of the fos , AP 1 , and HO genes was observed during this period , with the maximal transcriptional activities after TPA treatment for 0 . 5 , 1 , and 1 . 5 h , respectively . ^^^ Thus , the HO gene was activated by treatment with either heme or TPA , and the latter activation was associated with activations of the fos and AP 1 genes . ^^^ As the rat HO gene is known to have a TPA sensitive element in its promoter region , this gene was suggested to be activated by a fos AP 1 complex protein . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JUN C , the product of the c jun protooncogene , is a nuclear protein that can interact with FOS to modulate the activity of AP 1 responsive promoters . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Xenopus fos protein readily associates with murine jun ( AP 1 ) oncoprotein , and the complex binds efficiently to AP 1 recognition elements . ^^^ Furthermore , the Xenopus fos protein collaborates with mammalian jun protein to activate transcription from 12 O tetradecanoylphorbol 13 acetate responsive element . ^^^ The differential expression of fos during Xenopus development and its ability to regulate transcription in association with jun suggest a role during embryogenesis . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and jun : two into one will go . c jun was the first oncogene to be identified as a transcription factor thus realizing the long standing prediction that gene regulation plays a fundamental role in growth control . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mutational analyses of Jun show that the leucine zipper mediates dimerization with other Jun molecules or with the Fos protein and determines the three dimensional orientation of the adjacent basic region , facilitating interaction with DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun oncogenes transactivate chimeric or native promoters containing AP1 / GCN4 binding sites in plant cells . ^^^ In transient expression experiments , Fos and Jun strongly activated chimeric promoters composed of the TATA box region of the cauliflower mosaic virus 35S transcript preceded by one to five copies of an AP1 / GCN4 binding site . ^^^ Fos and Jun also stimulated a wheat high molecular weight glutenin promoter in which similar binding sites are located more than 500 base pairs from its transcription start site . ^^^ Both the DNA binding and the transcription activation domains of these proteins were required for proper promoter stimulation by Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Members of two of these families , the Jun and Fos related proteins , have been shown to directly interact and form heterodimeric complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The proto oncogene products Fos and Jun form a stable heterodimeric complex that functions in transcriptional regulation by interacting with the DNA sequence known as the AP 1 site . ^^^ Dimer formation occurs through the leucine zipper , a structural motif involving a heptad repeat of leucine residues that is conserved in several fos and jun related genes . ^^^ CRE BP 1 also forms heterodimers with Jun but not with Fos . ^^^ Thus , the DNA binding specificity and affinity of Jun are modulated by association with Fos or with CRE BP1 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The products of the Jun and Fos proto oncogenes form a heterodimer that binds to and activates transcription from 12 O tetradecanoylphorbol 13 acetate responsive promoter elements ( TGACTCA ) and AP 1 binding sites ( TGACATCA ) . ^^^ Domain swapping reveals the modular nature of Fos , Jun , and CREB proteins . ^^^ To assess the role of these two domains in three related proteins , Fos , Jun , and CREB , we carried out extensive domain swapping analysis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein sequence deduced from the open reading frame of a human placental cDNA encoding a cAMP responsive enhancer ( CRE ) binding protein ( CREB 327 ) has structural features characteristic of several other transcriptional transactivator proteins including jun , fos , C / EBP , myc , and CRE BP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , this peptide readily forms CRE binding heterodimers with full length CREB both synthesized by in vitro cell free translation and isolated from PC 12 cells , but did not heterodimerize with in vitro translated jun or fos . ^^^ Heterodimerization of CREB 327 does not form heterodimers with jun or fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Functional analysis of an isolated fos promoter element with AP 1 site homology reveals cell type specific transcriptional properties . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos , Jun and CREB basic domain peptides have intrinsic DNA binding activity enhanced by a novel stabilizing factor . ^^^ In this report we demonstrate that the basic domains of the oncoproteins Fos , Jun and the transcription factor CREB , possess the structural information necessary to compete for promoter specific binding . ^^^ To study the relative binding affinity of the basic motifs to specific promoter elements , we used synthetic peptides to compete for intrinsic Fos / Jun and CREB DNA binding activity present in HeLa cell nuclear extracts . ^^^ These studies demonstrate that the basic peptides of both Fos and Jun have higher affinity for the TPA responsive element ( TRE ) and the cAMP responsive element ( CRE ) relative to the corresponding peptide for CREB . ^^^ Our competition binding assay has also helped to identify a novel protein factor , termed ABP ( auxilliary bridging protein ) , which interacts to stabilize Fos and Jun basic domain binding interaction with specific promoter elements . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These AP 1 binding sites in HPV 16 and other papillomaviruses may provide a link between cellular oncogenes like jun , fos and possibly ras , whose transcription stimulating activity may lead to an elevated expression of the viral transforming genes E 6 and E7 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA ( PMA or TPA : phorbol 12 myristate 13 acetate ) responsive promoter elements ( TRE ) , the recognition site for the transcription factor AP 1 . ^^^ Coupled and uncoupled induction of fos and jun transcription by different second messengers in cells of hematopoietic origin . ^^^ The fos / jun heterodimer has a higher affinity to the TRE and stimulates transcription of responsive genes more than the jun homodimer . ^^^ We further defined the regulation of fos and jun by studying their inducibility by second messengers in cells of hematopoietic origin . ^^^ In THP 1 monocytic leukemia cells fos and jun mRNA levels are regulated in a coupled manner by second messengers activated after membrane phospholipid turnover . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This response element contains a consensus AP 1 site TGACTCA and in vitro is bound by the Jun Fos complex . ^^^ Jun Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene . ^^^ Unexpectedly , cotransfection of Jun and Fos expression vectors suppresses basal level transcription of the osteocalcin gene and suppresses induction by both retinoic acid and vitamin D 3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A portion of Region 2 also resembles part of the human c jun oncoprotein ' s leucine zipper , which in turn , has been demonstrated to be the heterodimerization site between the jun and fos oncoproteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antitumor promotion and antiinflammation : down modulation of AP 1 ( Fos / Jun ) activity by glucocorticoid hormone . ^^^ Coprecipitation experiments suggest direct AP 1 hormone receptor interaction , which also possibly explains the reverse experiment : overexpression of Fos or Jun inhibits the expression of hormone dependent genes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since heterodimers of the Jun and Fos proteins have been shown to bind to the phorbol ester responsive element ( AP 1 binding site ) , the present findings indicate that cAMP induced signaling events may also regulate gene transcription through formation of Fos / Jun heterodimers and that interaction between phorbol ester and cAMP dependent pathways could occur through induction of the c jun gene in these cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among nuclear oncogene families , such as myc , jun , fos , myb , or ets related , and among homologous proteins across species , the significant charge clusters are part of the most conserved region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this review we discuss the leucine zipper structure , which has been found in several nuclear factors , including the oncoproteins Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results demonstrate that the leucine zipper domain of avian cMyc is required for both transformation and autoregulation , and suggests that essential leucine residues within the motif may be spaced differently from those in the zippers of Fos and Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All three proteins , TREB 5 , TREB 7 and TREB 36 , contained a leucine zipper structure and basic amino acid domain , which are conserved in FOS , JUN and CREB , and also had multiple potential phosphorylation sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Specifically , it is a nuclear DNA binding protein with a short half life , a high proline content , segments that are rich in glutamine and acidic residues , and a carboxyl terminal oligomerization domain containing the leucine zipper and helix loop helix motifs that serve as oligomerization domains in known regulators of transcription , such as C / EBP , Jun , Fos , GCN 4 , MyoD , E 12 , and E 47 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The HS 2 enhancer consists of tandem AP 1 binding sites and has been shown to bind members of the ubiquitous jun and fos families of proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recently , it has been reported that the FOS protein is associated in transcriptional complexes with the product of the jun oncogene , the transcription factor AP 1 . ^^^ As the fos gene is induced in response to mitogens during initiation of cell growth , we investigated whether expression of the nuclear transcription factor AP 1 is also inducible . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun bind cooperatively to the AP 1 site : reconstitution in vitro . ^^^ The protein products of the fos ( Fos ) and jun ( Jun ) proto oncogenes have been shown to associate with a DNA element known as the transcription factor activator protein 1 ( AP 1 ) binding site . ^^^ Jun ( previously known as the Fos binding protein p 39 ) and Fos form a protein complex in the nucleus . ^^^ To investigate the nature of the association of Fos and Jun with the AP 1 site , and to determine the role of protein complex formation in DNA binding , we have reconstituted the protein protein and protein DNA interactions in vitro using Fos and Jun synthesized in reticulocyte lysates . ^^^ The Fos Jun complex formed extremely rapidly in vitro and possessed similar , though not identical , chromatographic and sedimentation properties to the complex isolated from cell extracts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The opaque 2 protein contains a domain similar to the leucine zipper motif identified in DNA binding proteins of animal protooncogenes such as fos , jun and myc , and in the transcriptional activators GCN 4 and C / EBP . ^^^ The region of 30 amino acid residues next to the leucine repeats towards the N terminus is rich in basic amino acids and is also homologous to a domain present in fos , jun and GCN 4 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The leucine repeat motif in Fos protein mediates complex formation with Jun / AP 1 and is required for transformation . ^^^ Cellular and viral Fos proteins form a tight complex with other nuclear proteins , including the transcription factor and proto oncogene AP 1 / Jun . ^^^ We have mapped the c Jun binding site in Fos to a region containing regularly spaced leucine residues recently suggested to interdigitate with a similar structure in Jun . ^^^ These results strongly suggest that the formation of a `` leucine zipper ' ' mediates the interaction between Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two functionally different regions in Fos are required for the sequence specific DNA interaction of the Fos / Jun protein complex . ^^^ THE products of the cellular and retroviral fos genes associate with other nuclear proteins , among them the transcription factor AP1 / Jun ( see ref . 3 for a review ) . ^^^ The Fos / Jun complex binds to a specific symmetrical DNA recognition sequence ( termed TRE ) , thus stimulating transcription of the respective gene . ^^^ Here , we show that two distinct regions in Fos are required for the formation of a Fos / Jun / TRE complex . ^^^ Specific amino acid substitutions in this basic , presumably alpha helical , region abolish the interaction of Fos / Jun with the TRE but not the association of the two proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein . ^^^ The products of the proto oncogenes c jun and c fos are known to form a complex in vivo . ^^^ Here we show that the viral Jun oncoprotein , which differs structurally from cellular Jun , is also capable of complex formation with Fos . ^^^ Thus the oncogenic potency of viral Jun is unlikely to be due to an altered affinity for Fos . ^^^ We find that complex formation with c Fos does not occur with 5 Jun deletions affecting one or more leucine residues in the zipper domain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The region of the C / EBP polypeptide required for direct interaction with DNA has been identified and shown to bear amino acid sequence relatedness with the product of the myc , fos , and jun proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The discovery that the AP 1 family of enhancer binding factors includes a complex of the cellular Fos ( cFos ) and cellular Jun ( cJun ) proteins established a direct and important link between oncogenesis and transcriptional regulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains . ^^^ The protein products of the fos and jun proto oncogenes form a heterodimeric complex that participates in a stable high affinity interaction with DNA elements containing AP 1 binding sites . ^^^ The effects of deletions and point mutations in Fos and Jun on protein complex formation and DNA binding have been examined . ^^^ The data suggest that Fos and Jun dimerize via a parallel interaction of helical domains containing a heptad repeat of leucine residues ( the leucine zipper ) . ^^^ Dimerization is required for DNA binding and results in the appropriate juxtaposition of basic amino acid regions from Fos and Jun , both of which are required for association with DNA . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The product of a novel growth factor activated gene , fos B , interacts with JUN proteins enhancing their DNA binding activity . ^^^ Immunoprecipitation studies showed that fos B as c fos protein , forms a complex in vitro with c jun and jun B proteins in the absence of a target binding sequence . ^^^ Gel retardation assays demonstrated that fos B protein positively influences the binding of c jun and jun B proteins to an AP 1 binding consensus sequence , suggesting that fos B protein plays a role in control of gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One of these complexes includes the product of the proto oncogene FOS or an antigenically related protein , and the FOS protein may , in turn , be associated with the product of the proto oncogene JUN . ^^^ Similarly , FOS and JUN proteins produced by translation in vitro bind cooperatively to the negative regulator . ^^^ These results raise the possibility that FOS and JUN participate in the regulation of MYC . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Growth factors and membrane depolarization activate distinct programs of early response gene expression : dissociation of fos and jun induction . ^^^ Prototype members of this group , c fos and c jun , encode products that form a heterodimer and have been implicated in the regulation of gene expression and cell growth . ^^^ Notably , c fos and c jun activation can be dissociated ; whereas c jun is coinduced with c fos and jun B after growth factor stimulation , membrane depolarization activates c fos and jun B without stimulating c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An AP 1 binding site in the c fos gene can mediate induction by epidermal growth factor and 12 O tetradecanoyl phorbol 13 acetate . ^^^ Although recent reports have shown that fos protein binds to AP 1 binding sites through an interaction with AP 1 protein and have raised the speculation that fos protein may negatively regulate expression of the c fos gene via this interaction , we found no role for the AP 1 consensus homology in the downregulation of c fos expression following induction by epidermal growth factor and TPA . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos and Jun / AP 1 proteins are involved in the downregulation of Fos transcription . ^^^ Fos and Jun / AP 1 protein cooperate in the repression mechanism . ^^^ Overexpressions of Fos and Jun decrease basal and induced transcription from Fos CAT constructs and from the endogenous gene in NIH3T3 cells . ^^^ The introduction into cells of either antisense Fos or antisense Jun sequences leads to elevated basal Fos promoter activity . ^^^ Gel retardation experiments with synthetic oligonucleotides define two target sequences in the Fos promoter which bind Fos Jun / AP 1 ( centering at about 296 and 60 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos Jun interaction : mutational analysis of the leucine zipper domain of both proteins . ^^^ Jun and Fos oncoproteins form a complex that regulates transcription from promoters containing AP 1 binding sites . ^^^ The ' leucine zipper ' domain of both Fos and Jun is necessary for the formation of the heterodimer , but the role of specific leucine residues is unclear . ^^^ We have used site specific mutagenesis to examine the contribution of individual leucine residues to the formation of a stable Fos Jun protein complex and the binding of this complex to the AP 1 site . ^^^ Mutation of a single leucine in either Fos or Jun had no effect on protein complex formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Preferential heterodimer formation by isolated leucine zippers from fos and jun . ^^^ The products of the nuclear oncogenes fos and jun are known to form heterodimers that bind to DNA and modulate transcription . ^^^ The leucine zipper regions from Fos and Jun therefore correspond to autonomous helical dimerization sites that are likely to be short coiled coils , and these regions are sufficient to determine the specificity of interaction between Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A Fos protein containing the Jun leucine zipper forms a homodimer which binds to the AP 1 binding site . ^^^ The TPA ( 12 O tetradecanoyl phorbol 13 acetate ) responsive element ( TRE ) is recognized by the inducible transcription factor AP 1 , a heterodimeric complex of Fos and Jun protein subunits , which each contain a specific structure known as the leucine zipper through which they interact . ^^^ Studies using site directed mutagenesis have shown that a basic region adjacent to the leucine zipper in Fos is crucial for the interaction of the Fos Jun complex with the TRE , and probably represents a site of interaction with DNA . ^^^ The functionally crucial amino acids in this region are almost completely conserved between Fos and Jun ( refs 6 , 7 and 11 ; M . ^^^ M . , unpublished results ) , indicating the formation of a nearly symmetrical DNA binding site in the Fos Jun complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transforming ras protein activated an intracellular signal pathway , which led to the induction of 12 O tetradecanoyl phorbol 13 acetate responsive elements ; activation was enhanced by coexpression of the proto oncogene jun ( encoding AP 1 ) and was further augmented by fos . ^^^ PC 12 cells : possible involvement of fos and jun . ^^^ We propose a possible involvement of fos and jun in ras induced differentiation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and fos oncoproteins form a complex which regulates transcription from promoters containing AP 1 binding sites . ^^^ We have used site specific mutagenesis to examine the contribution of individual leucine residues to the formation of a stable fos / jun protein complex and the binding of this complex to the AP 1 site . ^^^ Jun and fos oncoproteins form a complex which regulates transcription from promoters containing AP 1 binding sites . ^^^ The `` leucine zipper ' ' domain of both fos and jun is necessary for the formation of the heterodimer , but the role of specific leucine residues is unclear . ^^^ Mutation of a single leucine in either fos or jun had no effect on protein complex formation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Asymmetrical recognition of the palindromic AP 1 binding site ( TRE ) by Fos protein complexes . ^^^ Fos and Jun proteins form a tight complex which binds specifically to the AP 1 recognition sequence , a palindromic DNA element also referred to as the TPA responsive element ( TRE ) . ^^^ To elucidate the mechanism of Fos Jun interaction with the TRE we have performed UV cross linking studies using oligonucleotides where thymines were replaced with bromouracil . ^^^ Our results indicate that both Fos and Jun directly contact the TRE but that the interaction of Fos and Jun with thymines in structurally equivalent positions in the two half sites of the TRE is different . ^^^ The results of this analysis clearly show that the palindromic TRE is asymmetrical with respect to binding of Fos Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos Jun heterodimers and Jun alone , but not Fos alone , bind to the symmetrical sequences TGACTCA ( AP 1 site ) or TGACGTCA ( cAMP response element or CRE ) . ^^^ Heterodimers with mixed Fos and Jun leucine repeat segments showed high affinity binding to the AP 1 site or CRE whether they contained two basic regions from Jun , two basic regions from Fos , or one from each source . ^^^ Heterodimers with two Fos basic regions showed somewhat greater affinity for the CRE and AP 1 site than the heterodimer with two Jun basic regions . ^^^ The DNA binding domains of the members of the Fos and Jun families of proteins consist of a basic region followed by a dimerizing segment with heptad repeats of leucine . ^^^ We set out to test the hypothesis that in the Fos Jun heterodimer the basic region of Fos confers specific DNA binding properties equivalent to the contribution of the basic region of Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun co operatively repress the fos promoter . ^^^ Removal of all putative Fos / Jun binding sites from the fos promoter neither obliterates the repression by Fos / Jun in transient cotransfection experiments in NIH3T3 cells nor the turn off kinetics of serum induced fos expression in stably transfected NIH3T3 cells . ^^^ However , one of the putative Fos / Jun binding sites ( 292 to 299 and thus located immediately adjacent to the DSE ) , determines the very low level of basal expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although cFos , itself , does not seem to dimerize and bind to the AP 1 site , Jun : Fos heterodimers have higher stability than Jun homodimers , which accounts for their increased DNA binding activity . ^^^ Different requirements for formation of Jun : Jun and Jun : Fos complexes . ^^^ However , these residues can be mutated without affecting formation of Jun : Fos heterodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Behind the Fos and Jun leucine zipper . ^^^ The production of the nuclear oncoproteins Fos and Jun is rapidly induced in response to extracellular signals . ^^^ The resulting Fos Jun heterodimer can bind to the TPA responsive element ( TRE ) by way of a novel , highly basic motif and can activate the transcription of TPA responsive genes . ^^^ The existence of several Fos and Jun related proteins with dimerization and DNA binding properties similar to Fos and Jun suggests that these two oncoproteins may be part of a network of related but functionally distinct transcription factors . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The composition of AP 1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos related proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two nuclear oncoproteins , fos and jun ( AP 1 ) , cooperate in forming a very stable heterodimeric complex that binds to the AP 1 site with increased affinity . ^^^ The ' leucine zipper ' domain of both fos and jun is necessary for the formation of this heterodimer . ^^^ However , mutagenesis of the first leucine of the heptad repeat in either fos or jun basic regions and alteration of the spacing between the basic and leucine zipper domains indicate that the basic region of fos has a crucial role in determining the DNA binding affinity of the transcriptional complex . ^^^ Mutations of the basic amino acids in fos protein prevent binding to TPA ( phorbol ester ) responsive element ( TRE ) in the presence of wild type jun protein . ^^^ Thus fos protein appears to be dominant in jun fos binding to DNA , even though fos alone can not bind to TRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription factor AP 1 is a heteromeric complex composed of the Jun and Fos proteins . ^^^ Both Jun and Fos contribute to trans activation by the AP 1 complex , and the augmentation of Jun activity by Fos is probably due to the increased DNA binding activity of the Jun : Fos heterodimer . . ^^^ It has been shown that by associating with Jun , Fos increases Jun ' s ability to bind DNA and activate transcription . ^^^ We show that both the cellular Jun and its viral counterpart , 5 Jun , are efficient transcriptional activators even in the absence of Fos . ^^^ Although trans activation by Fos was previously shown to be dependent on the presence of Jun , by fusing Fos to a heterologous DNA binding domain we show that once given the ability to bind DNA on its own , Fos is also an independent trans activator . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Conformational energy analysis of the leucine repeat regions of C / EBP , GCN 4 , and the proteins of the myc , jun , and fos oncogenes . ^^^ It has been recently proposed that certain DNA binding proteins ( including C / EBP , GCN 4 and the myc , jun , and fos oncogene proteins ) share a common structural motif based on helix promoting regions containing heptad repeat sequences of leucines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Glutamate receptor agonists increase the expression of Fos , Fra , and AP 1 DNA binding activity in the mammalian brain . ^^^ Previous studies have established that Fos , as well as several Fra , contribute to transcription factor AP 1 nucleoprotein complexes along with Jun , the product of the jun proto oncogene . ^^^ The appearance in brain of Fos and Fra coincides with a protracted increase in total AP 1 DNA binding activity , indicating that all the Fos like proteins can participate in AP 1 complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The deduced amino acid sequence of the 5 maf gene product contains a `` leucine zipper ' ' motif similar to that found in a number of DNA binding proteins , including the gene products of the fos , jun , and myc oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These elements share no apparent sequence motif and bind different trans acting proteins ; a member of the NF kappa B family binds to the HIV 1 enhancer , the heterodimer of Jun and Fos ( AP 1 ) binds to the collagenase enhancer , and the serum response factors p 67 and p 62 bind to fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While strong c Jun or Jun D binding requires a perfect palindrome , Jun Fos complexes can also efficiently recognize sequences where the right half of the palindrome is less conserved ( TGACTAA or TGACGCA ) . . ^^^ Jun DNA binding is modulated by mutations between the leucines or by direct interaction of fos with the TGACTCA sequence . ^^^ As shown previously , addition of Fos strongly increases the affinity of Jun for DNA by forming a heterodimer . ^^^ The jun down mutation ( Asn 301 to Ala ) also diminishes DNA binding by the Fos Jun D heterodimer . ^^^ Ultraviolet cross linking experiments have shown that both Fos and Jun directly contact the TGACTCA palindromic sequence defined as a TPA ( 12 O tetradecanoyl phorbol 13 acetate ) response element or TRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of the neu tyrosine kinase induces the fos / jun transcription factor complex , the glucose transporter and ornithine decarboxylase . ^^^ Induction of the expression of jun mRNAs was an immediate early effect of EGF stimulation , followed by a marked increase in the biosynthesis of the fos / jun transcription factor complex and an increased transcription factor activity as measured by a recombinant transcription unit using chloramphenicol acetyltransferase assays . ^^^ In distinction , elevated AP 1 / PEA 1 activity in the absence of a significant increase in jun and fos expression was characteristic of the neu oncogene expressing cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The region of the C / EBP polypeptide required for specific recognition of DNA is related in amino acid sequence to other regulatory proteins , including the Fos and Jun transforming proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The products of these genes ( e . g . , FOS , JUN ) are DNA binding proteins and it is thought that they alter , perhaps in a coordinate fashion , the transcription of `` late effector genes . ' ' These late genes may code for enzymes , neuropeptides , receptors , ion channels , structural proteins , growth factors , etc . that may cause permanent biochemical and / or morphological changes in the brain that give rise to the kindled state . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two of these regulatory genes , fos and jun , are discussed in detail because of their induction by growth factors and their central role in the transactivation of genes which have been implicated in rheumatoid synovitis . ^^^ A model for gene activation in the rheumatoid synovium is proposed based on the premise that fos and jun are an important link in the intracellular transduction pathways used by cytokines to induce cellular phenotypic changes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP 1 is associated with fos protein . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos protein complex and several Fos related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 ( AP 1 ) . ^^^ The Fos complex and Fos related antigens recognize sequence elements that contain AP 1 binding sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The role of the leucine zipper in the fos jun interaction . ^^^ Mutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine residues stabilizes the interaction between the fos and jun proteins . ^^^ We show that the complex between fos and jun can bind to DNA more tightly than either protein alone and that basic residues adjacent to the leucine repeat of fos contribute to the DNA binding potential of the complex . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show that one of the fos associated proteins , p 39 , is immunologically and structurally related to nuclear factor AP 1 . ^^^ Cooperation between nuclear oncoproteins fos and jun is required for full activation of transcription from a TPA responsive promoter element in transfected mammalian cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increases in intraneuronal free calcium result in the rapid , transient , induction of the fos and jun proto oncogenes . ^^^ In the brain , c fos and c jun may be induced by elevated neuronal activity such as occurs during pentylenetetrazole ( PTZ ) seizures . ^^^ Fos and Jun form a noncovalent nucleoprotein complex that binds to the consensus recognition sequence of the AP 1 transcription factor . ^^^ Thus in a larger picture we envisage Fos and Jun as members of a concerted stimulus transcription coupling pathway that links alterations in external stimuli to long term adaptive responses . ^^^ In this context Fos , Jun and the other immediate early genes should be viewed as third messengers which are regulated by second messengers such as intracellular calcium . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Novel Jun and Fos related proteins in Drosophila are functionally homologous to enhancer factor AP 1 . ^^^ Antibody cross reactivity experiments suggest that these proteins are Drosophila homologs of proto oncogene products , Jun and Fos . ^^^ The Drosophila Jun and Fos related antigens , when separated , are individually capable of sequence specific DNA binding , and the Jun related antigen activates transcription in vitro . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The periodic array of at least four leucines was also noted in the sequences of the Fos and Jun transforming proteins , as well as that of the yeast gene regulatory protein , GCN 4 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In these alpha helix permissive regions of the jun and GCN 4 products there is also a lesser but still significant amino acid resemblance to the fos protein and a marginal degree of similarity to myc proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel supershift assays with Jun and Fos antibodies showed that the AP 1 transcription factor present in the various cell types was unable to recognize the 352 to 324 and 306 to 285 AP 1 putative binding sites . ^^^ Interestingly , Jun and Fos components of AP 1 interact with the variant TGGCTCA sequence located in the 247 to 222 region of both neurotropic strains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report here that Myc , but not Fos and / or Jun , was able to rescue the block . ^^^ In contrast , Fos and Jun , but not Myc , rescued the block induced by dominant negative Ras . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The resulting 5 Jun chimeric proteins , called 5 Juneb 1 and 5 Jungcn 4 , which can no longer dimerize with Jun or Fos , should only form homodimers in the cell . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factors are composed of the Fos and Fos related antigens as well as Jun and related proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results further define the functional requirements for transformation by Fos proteins and suggest that the subunit composition of AP 1 complexes is an important determinant of mitogenic signalling capability . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fourth is an AP 1 site , the target sequence for the proto oncoproteins fos and jun . ^^^ One proceeds through the EGF RE , which may be involved in nonmalignant hyperproliferation processes ; the other , through the AP 1 site and the fos jun proto oncoproteins , may be related to induction in malignant processes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Redox regulation is mediated by a conserved cysteine residue in the DNA binding domain of Fos and Jun . ^^^ Previously , we demonstrated that a DNA repair protein , Ref 1 , could stimulate the DNA binding activity of Fos Jun dimers by reducing this cysteine residue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Arabidopsis thaliana apurinic endonuclease Arp reduces human transcription factors Fos and Jun . ^^^ Arp stimulates in vitro DNA binding activity of the human transcription factor Jun and Fos by the reduction of a cysteine residue located in the DNA binding domain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The inducible nuclear transcription factor complex , AP 1 , typically consists of heterodimers between Jun and Fos proteins . ^^^ Although components are drawn from families of related molecules , little is known about the physiologic regulation of jun and fos related gene products . ^^^ They also indicate that separate intracellular pathways may be used for induction of jun and fos gene products and that the same transcription factor ( junB ) may be triggered by two surface receptors through separate pathways that differ in PKC dependence . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the axotomized neurons of the medial septal nucleus ( MS ) and ventral diagonal band of Broca ( VDB ) , the expression of Jun , Fos , Krox , CREB transcription factors , choline acetyltransferase ( ChAT ) and nitric oxide synthase ( NOS ) were studied by immunocytochemistry . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The two subunits that make up the AP 1 heterodimer , Fos and Jun , possess identical residues at positions that make sequence specific contacts to DNA . ^^^ However , in the cooperative complex formed with NFATp on a composite response element , the AP 1 bZip adopts a single orientation , with Jun and Fos bound to the NFATp proximal and NFATp distal half sites , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to evaluate the potential involvement of immediate early genes in ischemic tolerance , we examined Fos and Jun related protein immunoreactivity in gerbil brain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IEG expression was measured by immunocytochemistry for the FOS and JUN proteins . ^^^ NRB rats exposed for the first time to the maze showed extensive FOS and JUN positive cells in the reticular formation , the granular and pyramidal neurons of hippocampus , the amygdaloid nuclei , all layers of somatosensory cortex , and the granule cells of the cerebellar cortex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
An oligonucleotide representing the AP 1 recognition sequence also blocked the NFAT DNA binding activity , as did a combination of anti Fos and anti Jun antibodies . ^^^ Together these data suggest that the NFAT complex in mast cells contains Fos and Jun proteins as does NFAT in T cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neurotransmitter modulation of Fos and Jun like proteins in the turtle retina . ^^^ The expression of the Fos and Jun families of nuclear phosphoproteins can be induced by a variety of extracellular stimuli and is known to participate in the transcriptional regulation of target genes . ^^^ There were no dramatic differences in the levels of Fos like immunoreactivity or Jun like immunoreactivity between light or dark adapted retinas . ^^^ The excitatory amino acids increased both Fos and Jun like immunoreactivity , while GABA generally showed no such stimulatory effect . ^^^ Our results suggest that Fos and Jun related proteins may play an important role in the postsynaptic responses to amino acid transmitters in a wide variety of amacrine and ganglion cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Band shift and supershift assays identified Jun , Fos , and novel proteins in the hARE nuclear protein complexes that mediate regulation of the NQO 1 gene expression . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MK 801 blockade of Fos and Jun expression following passive avoidance training in the chick . ^^^ To determine the relationship between NMDA receptor up regulation and IEG induction during memory formation we have examined the expression of Fos , Jun and their related proteins 2 h following training in the presence / absence of the putative amnestic agent MK 801 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A cloning and expression system allowing display of functional cDNAs or other gene products on the surface of filamentous phage has been developed , exploiting the high affinity interaction of the Jun and Fos leucine zippers . ^^^ Using a second lacZ promoter of the phagemid , gene fos was co expressed as an N terminal fusion peptide to cDNA library gene products , so that the resulting Fos fusion proteins could become associated with the Jun decorated phage particles . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Secondly , analysis of a Fos derivative containing the GCN 4 leucine zipper indicates that Fos represents a novel intermediate between AP 1 and ATF / CREB proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine whether both arms are necessary or only one arm is sufficient for operator binding , we constructed heterodimeric repressors with two , one , or no arms by fusing the DNA binding domain of lambda repressor to leucine zippers from Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Clinical implication of fos and jun expressions and protein kinase activity in endometrial cancers . ^^^ Under the previous data of the presence of fos / jun expression via protein kinase C ( PKC ) activation by estrogen in endometrial cancer cell line ( 1 ) , the following experiment was made on the endometrial cancer tissue of the human subject . ^^^ The ratio of membrane / cytosol PKC activity and the level of fos / jun expression were significantly higher in well differentiated endometrial cancers than in those of moderately or poorly differentiated ones . ^^^ It is suggested that the linkage of fos / jun expression via PKC activation by estrogen might be exaggerated in the endometrial cancers , especially in the well differentiated , plausibly with the loss of the anti estrogen effect of progesterone , but dedifferentiation might lose this linkage . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immunoprecipitation of the gp 160 induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP 1 complex is comprised of members of these family of proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ref 1 is a nuclear protein that possesses DNA repair activity and has a role in the redox activation of Fos and Jun transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is shown herein that the 1 , 25 dihydroxyvitamin D 3 receptor binds to the osteocalcin 1 , 25 dihydroxyvitamin D 3 response element along with activator protein 1 ( AP 1 ) complexes and that the DNA binding activities of members of the Jun and Fos proto oncogene families , which make up the AP 1 transcription factor , are differentially regulated by 1 , 25 dihydroxyvitamin D 3 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA binding and in its ability to form an NFAT complex with Fos and Jun . ^^^ Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effects of truncated Fos ( residue 116 211 ) and / or Jun ( residue 224 334 ) proteins on the DNA replication of plasmid with or without an AP 1 binding site were examined in a cell free extract of Xenopus eggs . ^^^ These results suggest that truncated Fos and Jun proteins act together to stimulate DNA replication and that activation depends on the presence of an AP 1 binding site in the Xenopus cell free DNA replication system . . ^^^ Stimulation of DNA replication by truncated Fos and Jun proteins in a cell free extract of Xenopus eggs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Focal brain injury is known to markedly induce the fos and jun families of immediate early genes ( IEGs ) . ^^^ Since these zinc finger genes were expressed in the same regions where fos and jun family members are induced by similar types of brain injury , it is suggested that these transcription factors may act in concert with Fos / Jun family members . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , gel shift assays clearly demonstrate that DNA binding to AP 1 sites by Fos : DER heterodimers or DER homodimers is estrogen dependent . ^^^ Our results indicate that the DER protein is a direct , hormone reversible inhibitor of Fos and that estrogen controls the conditional positive or dominant negative activities of DER at the level of DNA binding to AP 1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When sympathetic neurons are deprived of NGF , the level of c Jun protein significantly increases , whereas the levels of the other members of the Jun and Fos family remain relatively constant . c Jun also becomes more phosphorylated , probably on its amino terminal transactivation domain . ^^^ We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of AP 1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos . ^^^ Since the binding of Jun Jun and Jun Fos dimers to the AP 1 DNA binding site is regulated in vitro by a redox process involving conserved cysteine residues , we hypothesized that some of the biological actions of gold and selenium are mediated via these residues . ^^^ Cysteine to serine mutants demonstrated that these effects of gold ( 1 ) and selenite require Cys 272 and Cys 154 in the DNA binding domains of Jun and Fos , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using a concatenated probe with several copies of this element to screen a lambda gt 11 cDNA expression library from mouse Swiss 3T3 fibroblasts , we report here the molecular cloning of a cDNA coding for a novel protein ( SPBP ) of 937 amino acids that binds to this element and has several features of a transcription factor , such as a putative leucine zipper region , a nuclear localization signal , and a basic domain with homology to the DNA binding domains of Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , we show that , unlike in other cases , trans activation of the vimentin AP 1 enhancer element can occur in undifferentiated embryonal carcinoma cells , despite the low amount of Jun and Fos proteins present in these cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When these morphologically altered CEF were challenged by superinfection with oncogenic retroviruses , they were resistant to transformation by the nuclear oncogenes jun , fos , junD , myc , and qin but were readily transformed by cytoplasmic oncogenes src , mil / raf , ras , and fps . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , neither Fos nor Jun , either alone or in combination with each other or c Maf , altered transcription from this element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , TGF beta 1 augmented AP 1 binding activity , suggesting that fos and / or jun protooncogene products could be implicated in the response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Neuronal expression of Fos and Jun protein in the rat medulla and spinal cord after anoxic and hypercapnic stimulations . ^^^ After inhalation of 100 % N 2 ( anoxia ) or 8 % CO 2 ( hypercapnia ) , neurons that express Fos protein ( FOS ) and / or Jun protein ( JUN ) were immunohistochemically identified in the CNS of rats anesthetized with urethane and alpha chloralose . ^^^ JUN labeled cells were characteristically found in the respiration related motor nuclei of the medulla and spinal cord , and in the central chemoreceptive area of the ventral medullary surface on which hypercapnia was more effective than anoxia , whereas FOS labeled cells were dominant in the respiration related sensory nuclei of the medulla on which anoxia was more effective than hypercapnia . ^^^ The results suggest that the peripheral chemoreceptor and the central chemoreceptive pathways in the medulla and spinal cord may be traced by a combination of FOS and JUN expression methods . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Jun proteins can form both homo and heterodimers within the Jun family and can also cross dimerize with the Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present report summarizes the current molecular biological aspects of several oncogenes ( erbB , ras , myc , raf , fos , jun , bcl , mdm 2 , myb , kit CSF1R , met ) and tumor suppressor genes ( p 53 , rb , mts ) involved in lung cancer development with respect to the pathology of lung tumors , including the importance of these genes as far as the clinical course of the disease is concerned . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We developed transgenic mice carrying fos lacZ fusion genes with clustered point mutations in each of several distinct regulatory sequences : the sis inducible element , the serum response element , the fos AP 1 site , and the calcium / cAMP response element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Whereas the encoded proteins of the three genes share highly conserved regions distinct from other bZIP families such as Jun or Fos , remaining regions diverged considerably from each other . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cyclosporin sensitive factor NFATp cooperates with Fos and Jun family proteins to regulate transcription of the interleukin 2 gene in activated T cells . ^^^ We have defined a 187 amino acid fragment of NFATp , located centrally within the protein sequence , as the minimal region required for DNA binding and for complex formation with Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several lines of evidence indicate that NOT and NAK1 / TR3 form a distinct and exclusive subgroup of orphan steroid receptors , whose expression characteristics in vitro and in vivo resemble the expression of nonsteroid immediate early transcription factors such as jun and fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The NF AT complex in T cells and B cells appears to be identical , comprising both Fos and Jun proteins and the 120 kDa cytosolic component of NF AT ( NF ATp ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To explore nuclear events involved in growth regulation by G protein coupled receptors in this setting , we compared the effect of platelet derived growth factor ( PDGF ) and the cholinergic agonist , carbachol , on the expression of mRNA for members of the jun and fos family of nuclear proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The maf oncogene encodes a bZip nuclear protein which recognizes sequences related to an AP 1 site either as a homodimer or as heterodimers with Fos and Jun . ^^^ This study shows that the small Maf proteins can also dimerize among themselves and with Fos and a newly identified p 45 related molecule ( Ech ) but not with 5 Maf or Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The effect of acute cyanide intoxication on levels of transcriptional regulatory proteins Fos and c Jun in rat cortex , hippocampus , cerebellum and brain stem was studied . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNA synthesis and Fos and Jun protein expression in mitotic and postmitotic WI 38 fibroblasts in vitro . ^^^ DNA synthesis of mitotic and postmitotic WI 38 cell populations may be regulated by the expression of Fos and Jun proteins . ^^^ The Fos level of MFs was higher by a factor of 15 24 and the Jun level of MFs by a factor of 4 . 2 6 . 3 than those of spontaneously arisen PMFs . ^^^ In 2 10 MMC induced PMFs , the Fos level was about 4 . 4 7 . 5 times higher and the Jun level 1 . 7 3 . 3 times higher than that of spontaneously arisen PMFs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TRE is a binding sequence of the transcription factor AP 1 , which consists of several closely related proteins belonging to the Jun and Fos family . ^^^ Jun and Fos related gene products bind to and modulate the GPE 1 , a strong enhancer element of the rat glutathione transferase P gene . ^^^ The gel retardation experiments show that all the heterodimers formed between the Jun and Fos related gene products bind to the GPE 1 as well as to the TRE . ^^^ Co transfection studies of the reporter construct containing the GPE 1 and expression constructs of each of the Jun and Fos family cDNAs indicate that FosB and delta FosB repress transcription through the GPE 1 enhancer . ^^^ These results suggests that some of Jun / Fos family may regulate the rat GST P gene expression through the GPE 1 in vivo . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Consistent with this possibility , IL 1 and TNF alpha markedly increase the binding of Fos and Jun to the AP 1 site , and NF IL 6 activates the native TSG 6 promoter . ^^^ Thus , the functionally distinct NF IL 6 isoforms cooperate with Fos and Jun to positively and negatively regulate the native TSG 6 promoter by TNF alpha and IL 1 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using Fos and Jun deletion derivatives , we found that an acidic Fos region ( amino acids 118 to 138 ) , outside the DNA binding and dimerization domains , was necessary for the in vitro reconstitution of the NFAT complex in both B and T lymphocyte extracts although it was not required for binding to an AP 1 site . ^^^ Mutating a variant AP 1 site in the NFAT oligonucleotide abolished both direct binding of Fos Jun heterodimers and in vitro reconstitution of NFAT . ^^^ These results demonstrate a central role of Fos in NFAT complex formation in both B and T lymphocytes and show that NFAT assembly involves direct binding of Fos Jun heterodimers to a variant AP 1 site within the human NFAT recognition site . . ^^^ Nuclear factor of activated T cells ( NFAT ) is a multicomponent transcription factor that contains Fos and Jun family proteins in addition to a constitutively expressed factor ( s ) . ^^^ Here we show that NFAT complexes in B and T cell nuclear extracts can be supershifted prominently with Fos antibodies and to a variable extent with Jun family protein antibodies . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The c maf proto oncogene and the neural retina specific gene nrl encode members of a subfamily of bZIP proteins that form heterodimers with Fos and Jun . ^^^ We have determined the DNA binding specificities of various homo and heterodimeric combinations among Nrl , Maf , Fos and Jun . ^^^ Fos Jun heterodimers and Jun homodimers bound to a palindromic TGAC ( G ) TCA recognition sequence as previously demonstrated . ^^^ Fos Nrl , Jun Nrl and Fos Maf heterodimers bound to nonpalindromic recognition sequences with the consensus sequence TGAC ( N ) 3 4GCA . ^^^ These results indicate that Nrl and Maf have a DNA binding specificity distinct from that of Fos and Jun , and that each subunit in the dimer independently recognizes one half of the recognition sequence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although EGF and TGF alpha enhanced tyrosine phosphorylation of both receptors , CHO cells expressing HER497K exhibited an attenuated growth response to EGF and TGF alpha and a reduced induction of the protooncogenes FOS , JUN , and MYC . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Binding of the 160 kDa protein to oligonucleotides containing the ARE in gel mobility shift assays is diminished or abolished by increasing concentrations of the reducing agent dithiothreitol , but not by anti Jun or anti Fos antibodies . ^^^ The effect of dithiothreitol is opposite to that observed for the Ref 1 mediated binding of Fos / Jun to the ARE or to the related 12 O tetradecanoyl phorbol 13 acetate responsive element ( TRE ) . ^^^ The 160 kDa protein does not contain Fos or Jun proteins , and its binding is abolished by the reducing agent , dithiothreitol . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The physical linkage of cDNA encoded proteins to the genetic information required for their production , achieved by exploiting the high affinity interaction of the Jun and Fos leucine zippers , allows screening of up to 1 10 10 ( 10 ) independent clones in 50 microliters aliquots applied to a well of a microtiter plate coated with the ligand . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The methyl deficient diet may have caused activation of the transcription factor fos and thus the activation of the transcription regulatory complex , AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Kainate also induced biphasic increases in the concentrations of some of the AP 1 constituent proteins ( immediate early gene protein products ) , with initial increases of c Jun , Fos , and Jun B occurring at 1 . 5 h and secondary larger increases at 4 . 5 h , but the level of Jun D was not altered by kainate treatment . ^^^ Binding of the activated glucocorticoid receptor to c Jun or Fos is likely to contribute to the decreased AP 1 DNA binding activity following dexamethasone treatment . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Influence of age on the production of Fos and Jun by influenza virus exposed T cells . ^^^ Immunofluorescent staining and flow cytometric analysis were then used to detect T cells producing the transcriptional regulating proteins Fos and Jun . ^^^ Fewer virus exposed cells from elderly donors stained for Fos and Jun at each data point compared with cells from young donors . ^^^ Flow cytometric analysis also showed that at 72 h of virus exposure fewer T cells from the elderly produced interferon gamma ( IFN gamma ) , suggesting a link between the magnitude of the Fos and Jun and IFN gamma responses . ^^^ Thus , failure of virus exposed T cells to produce Fos and Jun could contribute to the increase in illness due to influenza virus in the elderly . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Tissue differences in the expression of mRNAs of Ha ras , c myc , fos and jun in human uterine endometrium , myometrium and leiomyoma under the influence of estrogen / progesterone . ^^^ Ha ras expression level in uterine endometrium ( EM ) in the proliferative phase ( PP ) was significantly higher than that in the secretory phase ( SP ) . c myc expressions were detected in EM , uterine myometrium ( MM ) and uterine leiomyoma ( LM ) without any cyclic change ; fos expressions in LM , MM , and EM were detectable in PP , but not in SP . jun expression level in LM was significantly higher than that in MM and EM in PP , but did not alter during the menstrual cycle . ^^^ Estrogen elevated the levels of Ha ras and fos mRNAs in the three tissues , jun mRNA in MM and EM , and c myc mRNA in LM and MM . ^^^ These results suggest that there is a tissue difference in the expression of Ha ras , c myc , fos and jun among EM , MM and LM , under the influence of estrogen / progesterone . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and Fos regulation of NAD ( P ) H : quinone oxidoreductase gene expression . ^^^ High basal expression of the NQO 1 gene and its induction by beta NF and BHA are mediated by 31 bp of the antioxidant response element ( ARE ) containing more than one copy of the AP1 / AP1 like binding sites , Jun and Fos and other ( s ) as yet unknown regulatory proteins . ^^^ The possibilities include involvement of protein ( s ) which receive signals from beta NF and BHA and modulate the Jun and Fos proteins for increased binding to the ARE element or increased activities of the transcriptional activation domains of the regulatory proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear proteins of the CREB , Fos , and Jun families bind to these sites , but , surprisingly , their levels only show limited regulation during NTERA 2 differentiation . ^^^ This suggests novel members able to interact via leucine zippers with other members of the Jun Fos CREB family of DNA binding proteins that are also involved in this regulation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Energy transfer analysis of Fos Jun dimerization and DNA binding . ^^^ The protooncogenes fos and jun encode proteins that bind to DNA as dimeric complexes and regulate gene expression . ^^^ We have developed an approach based on resonance energy transfer for the quantitative analysis of dimerization and DNA binding by Fos and Jun in solution . ^^^ Fos ( 118 211 ) and Jun ( 225 334 ) polypeptides were labeled with either 5 iodoacetamidofluorescein or rhodamine 10 iodoacetamide on unique cysteine residues located in their DNA binding domains . ^^^ Using this assay , we determined the affinity of the Fos Jun interaction and examined the kinetics of dimerization and DNA binding as well as the rate of subunit exchange . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
TNF regulates some of its cellular responses via induction of the transcription factors NF kappa B and AP 1 ( jun / fos ) . ^^^ Induction of jun and fos proteins ( polypeptide components of AP 1 ) are mediated via pathways involving protein kinase C and the protein kinase encoded by the raf proto oncogene . ^^^ The induction of jun and fos proteins ( as detected by Western blot analysis ) showed greater heterogeneity . ^^^ The data suggest that the pathways for the activation of jun and fos by TNF are defective in some B CLL and HCL cells and that these defects may be heterogeneous . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These proteins include mdr 1 encoded P glycoprotein , metallothionein , glutathione S transferase ( GST ) , dTMP synthase , and the proteins Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays suggest that this binding is due to AP 1 nuclear factors and that members of the jun family are induced to a greater degree than fos by hypoxia . ^^^ Thus , the hypoxic response of DT diaphorase expression is mediated in part through AP 1 , initially by a jun related mechanism and then by the involvement of fos . ^^^ The affinity of transcription factors for the AP 1 binding site depends on the redox state of a cysteine residue located close to the DNA binding region of both Fos and Jun . ^^^ A nuclear protein , Ref 1 , maintains the reduced state of Fos and Jun and promotes binding to AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differences between drug sensitive and resistant human leukemic CEM cells in c jun expression , AP 1 DNA binding activity , and formation of Jun / Fos family dimers , and their association with internucleosomal DNA ladders after treatment with VM 26 . ^^^ Using Jun and Fos family member antibody inhibition experiments in gel mobility shift assays , we found that AP 1 binding activity appeared to be preferentially mediated by c Jun / Fra 1 heterodimers in both CEM and at MDR cells . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EB 1 belongs to the Jun , Fos , ATF , CREB , C / EBP and GCN 4 family of proteins , carrying a sequence specific DNA binding domain called `` basic Zipper ' ' ( bZIP ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ether lipid 1 octadecyl 2 methyl rac glycero 3 phosphocholine induces expression of fos and jun proto oncogenes and activates AP 1 transcription factor in human leukaemic cells . ^^^ Addition of ET 18 OCH 3 to these human leukaemic cells induced an increase in the steady state mRNA levels of fos and jun proto oncogenes , components of the transcription factor AP 1 . ^^^ These increases in fos and jun mRNA levels were associated with the activation of the AP 1 transcription factor after addition of ET 18 OCH 3 to human leukaemic cells , as assessed by an enhanced binding activity of transcription factor AP 1 to its cognate DNA sequence as well as by stimulation of transcription from an AP 1 enhancer element . ^^^ These data demonstrate that the ether lipid ET 18 OCH 3 can affect gene expression by inducing expression of fos and jun proto oncogenes and by modulating the activity of transcription factor AP 1 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The enhanced DNA binding of oxidized HoxB 5 protein is the opposite of the redox regulation reported for other mammalian transcription factors such as Fos , Jun , USF , NF kappa B , c Myb , and 5 Rel , in which oxidation of cysteine residues inhibits DNA binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Maf and Nrl can bind to AP 1 sites and form heterodimers with Fos and Jun . ^^^ Maf and Nrl were also able to form heterodimers with Fos and Jun in vitro . ^^^ All pairwise combinations of Maf , Nrl , Fos and Jun could be co immunoprecipitated by antisera directed against either subunit . ^^^ These results indicate that Maf and Nrl together with Fos and Jun family proteins form a bZIP protein superfamily whose members can form an array of heterodimers that have overlapping DNA binding specificities . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gene products of different IEG families ( JUN and FOS proteins ) and cAMP responsive element binding protein ( CREBP ) were examined by immunohistochemistry under three different paradigms . ^^^ In both groups , the time course of RGC survival and JUN , CREB , and FOS protein expression was monitored . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This immunoelectron pattern seems to indicate that active genes containing activator protein 1 and cyclic AMP response element recognition sites are extensively distributed in euchromatin regions and suggests that the Fos positive nuclear domains correspond to the actively transcribing chromatin regions , at least in supraoptic neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Kinetic analyses suggest that the aforedescribed biological effect is mediated by the AP 1 complex ( JUN / FOS ) when dealing with rapid inhibition ( HT 29 D 4 and IEC 6 ) and by an autocrin TGF beta loop when dealing with slow inhibition ( IEC 6 ) . . ^^^ Effect of interleukin 2 on the proliferation of two intestinal cell lines and on the expression of TGF beta gene and JUN / FOS oncogenes ] . ^^^ Northern blot characterization of cellular mRNA revealed that interleukin 2 enhances the expression of JUN , FOS and TGF beta which are known to be involved in antiproliferative processes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun , Fos , MyoD 1 , and myogenin proteins are increased in skeletal muscle fiber nuclei after denervation . ^^^ After denervation , mRNA levels of the jun and fos protooncogenes and of the muscular differentiation factors myoD 1 and myogenin are increased . ^^^ An increase in Fos and Jun as well as MyoD 1 and Myogenin immunoreactivity was found after 2 2 . 5 days of denervation . ^^^ Fos , MyoD 1 , and Myogenin immunoreactivity was mostly confined to muscle cell nuclei , whereas Jun antibodies stained muscle cell and some interstitial cell nuclei . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Despite the high homology of the sequence 137 / 131 to the consensus AP 1 binding site ( TRE ) , the nuclear factor ( s ) in AtT 20 cells binding to this region appears to be different than authentic AP 1 since neither a competitor oligonucleotide having the authentic TRE sequence nor antibodies against Jun or Fos affected the gel shift pattern of a probe having the 137 / 131 sequence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We and others have shown previously that under cell culture conditions , the regulation of human collagenase 1 is regulated by the transcription factor Fos / Jun ( AP 1 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Because many of the early genes operating in T cell mitogenesis possess a TPA response element ( TRE ) in their promoter region , we tested the effect of cAMP on the TRE binding protein , TPA response element ( TRE ) in their promoter region , we tested the effect of cAMP on the TRE binding protein , AP 1 . dbcAMP increased the binding activity of nuclear proteins consisting of Fos : Jun heterodimers to a TRE containing oligonucleotide , but altered the composition of Jun proteins in the AP 1 . ^^^ Evidence that cAMP alters PKC induced transcription regulation of members of the jun and fos family of genes . ^^^ Furthermore , the TPA plus ionomycin induced transcription program of members of the jun and fos family of genes was altered by dbcAMP , suggesting that inhibition of T cell proliferation by dbcAMP is a consequence of intervention in transcriptional regulation by TRE binding proteins . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It is clear that URE bound proteins consist of multiple transcription factors , some of which are well characterized ( i . e . , jun , CREB , and fos families ) ; however , it is likely that the growth release phenomenon we relate to is also mediated by ( 1 ) other members of these transcription factor families which have not been identified as yet and ( 2 ) a specific combination of known transcription factors which bind to this response element under certain circumstances . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel shift analysis with and without antisera to Fos and CREB showed that AP 1 binding activity , containing Fos protein , was induced by hyperosmotic stress . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the ARE is responsive to TPA and shows some sequence similarity to an AP 1 binding site ( Jun / Fos recognition motif ) , we have explored whether members of the Jun / Fos family of transcription factors might bind to the ARE . ^^^ Using in vitro synthesized Jun and Fos , binding to the ARE could not be detected , whereas Jun / Fos binding to a classical AP 1 binding site , a TPA response element ( TRE ) from the human collagenase gene , could be demonstrated by gel retardation assays . ^^^ Taken together , our data suggest that the ARE is not a high affinity binding site for the Jun / Fos heterodimer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using cotransfection assays in P 19 embryonal carcinoma cells , we show that NF L promoter fragments fused to the reporter chloramphenicol acetyltransferase gene can be trans activated by expression vectors encoding FOS and JUN ( AP 1 ) and by Krox 24 protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear factor Fos participates in the transcriptional regulation of genes that contain a functional AP 1 binding site . ^^^ Double immunofluorescence staining of Fos and Jun in the hypothalamus of the rat . ^^^ Fos appears to depend on the co expression of the nuclear factor Jun , with which it dimerizes , to complete its regulatory role . ^^^ The present study was designed to analyze the distribution of Fos and Jun by double immunofluorescence staining in Long Evans rats that were osmotically challenged by a single intraperitoneal injection of 1 . 5 M NaCl . ^^^ The immunofluorescence for Fos in all 3 nuclei followed a similar pattern to that for Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To understand the role of endogenous AP 1 activity in cellular transformation induced by oncogenes , we have made use of a fos mutant ( supfos 1 ) and a jun mutant ( supjun 1 ) , either of which can function as a transdominant inhibitor of AP 1 mediated transcriptional regulation . ^^^ Cellular transformation induced by several exogenously expressed transforming genes of the fos or jun family was efficiently suppressed , as expected . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos Jun complexes , capable of binding to AP 1 sequences , were present continuously during the delay in morphological transformation . ^^^ The proto oncogene transcription factors Fos and Jun form a heterodimeric complex that binds to DNA and regulates expression of specific target genes . ^^^ Thus , the Fos Jun complexes present before L 1 3c fos cells become fully transformed are transcriptionally active . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These include peptide growth factors ( FGF and TGF beta ) , immediate early gene products ( Fos , Jun and Myc ) , other oncogene products ( Ras , Src ) , the Id protein , and innervation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and Fos are major components of the transcriptional complex AP 1 ( Activator Protein 1 ) , a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins , that bind to a common site known as TRE ( TPA Responsive Element ) or the AP 1 site . ^^^ Jun and Fos are major components of the transcriptional complex AP 1 ( Activator Protein 1 ) , a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins , that bind to a common site known as TRE ( TPA Responsive Element ) or the AP 1 site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Two pairs of oppositely charged amino acids from Jun and Fos confer heterodimerization to GCN 4 leucine zipper . ^^^ The preferential assembly of Jun and Fos into heterodimers has been shown to be mainly driven by 16 amino acids ( 8 from each protein ) situated in positions e and g of the leucine zipper coiled coil structures of the two proteins ( O ' Shea , E . ^^^ These residues are 2 glutamic acid side chains in positions g 1 and e 2 of the Fos leucine zipper and 2 lysine residues in the equivalent positions of the Jun zipper . ^^^ On the contrary , peptides harboring the 12 amino acids from Jun and Fos in the other e and g positions ( i . e . in e 1 , g 2 , e 3 , g 3 , e 4 , and g 4 ) show only a moderate tendency to form heterodimers . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although no conventional estrogen responsive element was identified within the promoter fragment , the AP 1 motif located therein was shown to be essential ; the estrogen responsive enhancement of the Fos Jun binding to the AP 1 motif , which takes place by means of post translational modification , mediates the estrogen action . ^^^ A direct or indirect interaction between the estrogen ER complex and the Fos Jun complex seems to facilitate the Fos Jun binding to the target DNA . ^^^ In conclusion , our present observations demonstrate that the chicken IGF 1 gene promoter is controlled by estrogen through a unique pathway involving Fos , Jun , and the DNA binding domain of ER . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The protein products of the jun and fos oncogenes require a functional protein protein interaction domain , called the `` leucine zipper domain ' ' , to exert their transcriptional regulatory activity . ^^^ A scintillation proximity assay was developed in which the biotinylated leucine zipper domain of the Jun protein ( 275 315 ) was immobilized on streptavidin coated microfluorospheres and in which the leucine zipper domain of the Fos protein ( 160 200 ) was used as free , labeled ligand . ^^^ The Fos leucine zipper peptide specifically bound to the Jun leucine zipper peptide , and for the first time , a dissociation constant ( Kd = 110 + / 12 nM in PBS / 0 . 1 % Tween ) could be determined . ^^^ A commercially obtained recombinant Jun protein competed as efficiently as the Jun leucine zipper peptide for binding to the Fos peptide , confirming the feasibility of using the two leucine zipper peptides to study the interactions between the two transcription factors . ^^^ We also injected leucine zipper peptides individually into Xenopus oocytes to study whether they would interfere with the activity of the Fos / Jun heterodimer in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immediate early genes ( IEGs ) , including the fos , jun , and NGFI A families , are induced by a wide variety of intracellular signaling pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest that the HO gene is activated at the spermatogonia stage by a fos / jun heterodimer complex ( AP 1 ) through c kinase activation . . ^^^ As the mouse HO gene is known to have a 12 o tetradecanoyl phorbol 13 acetate ( TPA ) responsive element ( TRE ) in its upstream region and is activated by TPA in mouse M 1 cells , we also examined the activation of the nuclear proto oncogenes fos and jun , which are activators of TRE . ^^^ Moreover activation of fos , jun and HO genes in spermatogonia was strongly inhibited by a c kinase inhibitor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To learn how light and circadian phase affect the binding of Fos to DNA , we analyzed the photic and temporal regulation of immunoreactive Jun protein expression and AP 1 DNA binding activity in the rat suprachiasmatic nucleus . ^^^ Immunohistochemistry and gel mobility shift assays suggest that AP 1 activity during the night and after a light pulse consists of constant , as well as variable , protein components ; JunD could be identified as a constituent of both dark and light activated binding complexes , whereas binding by JunB and Fos could be implicated only after photic stimulation . ^^^ Since JunD or JunB could be colocalized with Fos in individual suprachiasmatic nucleus cell nuclei , light may be acting in at least some suprachiasmatic nucleus cells by altering AP 1 protein composition rather than binding site occupancy . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of a non receptor type protein tyrosine phosphatase ( the T cell phosphatase or PTP S ) which shows homology with basic domains of Fos and Jun , was investigated upon mitogenic stimulation of rat splenic T lymphocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Other experiments demonstrated that the AP 1 complexes expressed by stimulated T cells of elderly and young subjects exhibited similar properties in gel shift assays with competing unlabeled AP 1 oligonucleotides and with blocking antibodies specific for Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Intriguingly , autonomous growth correlates with the suppression of CSF 1 mediated MAP Kinase activation and with the low constitutive expression of a number of CSF 1 inducible genes , including fos , jun , ets 2 , and myc , but also the genes for the inflammatory cytokines TNF alpha and IL 1 beta . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thus , JUN and FOS bind to the AP 1 site in the promoters of cellular genes and activate their transcription , resulting in maturation of the monocyte into a macrophage . ^^^ Intrinsic to this maturation is the induction of a class of immediate early genes in the monocyte that includes the transcription factors JUN and FOS . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increasing the number of stimulus trains resulted in a greater probability of eliciting long term potentiation with a time constant of several weeks ( long term potentiation 3 ) , as well as increasing the induction of zif / 268 , c Jun , Jun B , Jun D and Fos related proteins . ^^^ One possible mechanism is altered gene expression , initiated by immediate early gene transcription factors such as zif / 268 and possibly homo or heterodimers of Fos and Jun family members , that then contributes to the stabilization or maintenance of long term potentiation 3 . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cascade includes SRC family kinase members such as lck , fyn , and lyn , activation of Raf 1 and PI 3K , and ras , and increased expression of the fos , fra 1 , and jun protooncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of AP 1 expression and activity in antigen stimulated mast cells : the role played by protein kinase C and the possible involvement of Fos interacting protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , Cys SOH derivatives have been suggested to play important roles in redox regulation of the DNA binding activities of transcription factors such as Fos and Jun , OxyR , and bovine papillomavirus type 1 E 2 protein . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NF IL 6 homodimers can bind to both NF IL 6 and AP 1 sites , whereas Fos and Jun can not bind to most NF IL 6 sites . ^^^ Fos and Jun repress transcription activation by NF IL 6 through association at the basic zipper region . ^^^ We show that the basic leucine zipper ( bZIP ) region of NF IL 6 mediates a direct association with the bZIP regions of Fos and Jun in vitro . ^^^ Cross family association with Fos or with Jun alters the DNA binding specificity of NF IL 6 and reduced its binding to NF IL 6 sites . ^^^ Activation of a reporter gene linked to the NF IL 6 site by NF IL 6 is repressed by Fos and by Jun in transient transfection assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Maf nuclear oncoprotein recognizes sequences related to an AP 1 site and forms heterodimers with both Fos and Jun . ^^^ Furthermore , Maf efficiently formed heterodimers with the components of AP 1 , Fos and Jun , through their leucine zipper structures , and these heterodimers show binding specificities distinct from those for Maf Maf and Jun Jun homodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using gel shift assays , we demonstrated that RXR alpha inhibits Jun and Fos DNA binding and that 9 cis RA enhances this inhibition , suggesting that a mechanism involving direct protein protein interaction between RXR and AP 1 components mediates the inhibitory effect observed in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several factors , including AP 1 ( Jun / Fos ) , contribute to the cell type specific transcription of HPV genes . ^^^ Pulse chase experiments indicated that Jun and Fos are relatively stable in human keratinocyte cells after serum induction , whereas in early passage human fibroblasts they are rapidly broken down . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It was found that deletion of a fragment containing the binding site for transcription factor AP 1 ( Jun Fos ) substantially decreases inducibility of the human c myc promoter by preS2 / St . ^^^ A subsequent investigation of AP 1 activation by preS2 / St revealed the following : ( a ) insertion of multimeric AP 1 binding sites confers inducibility to an otherwise unstimulatable test promoter ; ( b ) transactivation of AP 1 sites is dramatically increased when Jun and Fos are overexpressed by cotransfected expression plasmids ; and ( c ) inhibitors of AP 1 activation also impair transactivation by preS2 / St . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential roles for Fos and Jun in DNA binding : redox dependent and independent functions . ^^^ The Fos and Jun family of transcription factors contain an invariant sequence motif lysine cysteine arginine ( KCR ) in the highly conserved DNA binding region . ^^^ Here , we examined the potential dual roles of the flanking lysine and arginine residues in influencing the redox reactivity of the cysteine and the DNA binding activity of Fos and Jun . ^^^ Two sets of Fos and Jun mutants were generated : the KCR and KSR series representing proteins capable of redox dependent and redox independent DNA binding activity , respectively . ^^^ Mutation of the lysine in Fos Jun heterodimers had no obvious effect on the redox reactivity of the cysteine , suggesting that lysine is not essential in this respect . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although TPA stimulates expression of the jun and fos family genes , only c jun expression shows higher elevation in P+ cells than in P cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cellular targets of DNA PK are nuclear , DNA binding , regulatory proteins including Sp 1 , Fos , Jun , Myc , the tumor suppressor protein p 53 , and RNA polymerase 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The gene products of fos , jun and Krox , multimember gene families that belong to the class of IEGs , participate in a fundamental biological control mechanism , the regulation of gene transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Their expression is greatly modulated by cytokines and growth factors and involves the gene products of the Fos and Jun families of oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As part of our investigation into the signal transduction pathway responsible for the hypoxia and cobalt induction of these genes , we discovered that the expression of members of the jun and fos protooncogene families is also up regulated early after exposure to either of these stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 is a transcriptional activator composed of homo and heterodimers of Jun and Fos proteins . ^^^ Transcriptional control of jun and fos gene expression determines the amount and composition of the AP 1 complex . ^^^ AP 1 is a transcriptional activator composed of homo and heterodimers of Jun and Fos proteins . ^^^ The jun and fos genes are regulated both positively and negatively and are highly inducible in response to extracellular stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased immunoreactivity for Jun and Fos related proteins in Alzheimer ' s disease : association with pathology . ^^^ The protein products of the Jun and Fos immediate early gene ( IEG ) families are cooperative transcriptional regulatory factors implicated in regulating the expression of many genes . ^^^ In order to evaluate the potential involvement of IEGs in AD pathology , we have examined Jun and Fos related protein immunoreactivity in control and AD brain . ^^^ Specifically , we investigated the correspondence of immunoreactivity for Jun and Fos proteins with immunoreactivity for paired helical filament 1 ( PHF 1 ) , a marker for neurofibrillary tangles which recognizes abnormally phosphorylated tau , glial fibrillary acidic protein ( GFAP ) , and thioflavine staining in double labeling experiments . ^^^ An intensification of both Jun and Fos immunoreactivity was observed in AD cases ; in addition , both Jun and Fos immunoreactivity were colocalized with PHF 1 in some neurons in AD brain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Competition with an AP 1 motif or with anti Jun and anti Fos antibodies abolished binding to the NFAT motif in both T and B cells , indicating that Jun and Fos are critical for NFAT complex formation in both cell types . ^^^ Purified recombinant Jun and Fos proteins failed to bind directly to the NFAT motif . ^^^ However , when combined with unstimulated B or T cell extracts , full length , but not truncated , Jun / Fos heterodimers were able to form an NFAT complex , indicating the presence of a constitutively expressed nuclear factor ( s ) in B and T cells necessary for the formation of the NFAT complex in both cell types . ^^^ We therefore propose a model whereby a core NFAT complex consisting of Jun , Fos , and a constitutive nuclear factor is formed in both T and B cells , but an additional factor and / or post translational modification of a factor , missing in B cells , might be required for transactivation by NFAT . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun transcription factors are induced during the normal course of the proliferative response of quiescent cells to serum or to growth factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated the expression of the immediate early proteins ( IEPs , Fos , Fos B , Jun , Jun B , Jun D , Krox 20 and Krox 24 ) in non nerve cells in rat brain after mechanical brain injury . ^^^ Injury produced by infusion of 5 microliters of saline into the hippocampus produced a time dependent expression of Fos , Jun and Krox 24 , but not Fos B , Krox 20 or in non nerve cells around the wound margin , in cells lining the lateral and third ventricles and in cells in the pial surfaces of the brain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun immunoreactivities are also increased after ischemia , and provide indexes of functional gene expression during earlier recirculation periods . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NF AT is thought to consist of two components : a ubiquitous , inducible nuclear component that we have identified as Fos and Jun proteins , and a preexisting , T cell specific component ( NF ATp ) which is the target for the immunosuppressive agents cyclosporin A ( CsA ) and FK 506 . ^^^ Moreover we present evidence that the component that forms the faster migrating ( `` lower ' ' ) nuclear NF AT complex is derived by a calcium dependent , cyclosporin sensitive , posttranslational modification of NF ATp , and that Fos and Jun proteins stabilize its interaction with DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun form dimeric complexes that bind to activator protein 1 ( AP 1 ) DNA sequences and regulate gene expression . ^^^ Phosphorylation of Fos by cAMP dependent protein kinase and cdc 2 is relatively insensitive to dimerization and DNA binding , whereas phosphorylation of Fos and Jun by DNA dependent protein kinase is dramatically stimulated by binding to the AP 1 site . ^^^ Dimerization and DNA binding alter phosphorylation of Fos and Jun . ^^^ The role of Fos and Jun in gene transcription is complex and may be regulated in several ways including association with different dimerization partners , interactions with other transcriptional factors , effects on DNA topology , and reduction / oxidation of a conserved cysteine residue in the DNA binding domain . ^^^ In addition , phosphorylation has been suggested to control the activity of Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This regulatory mechanism has been proposed , in part , because the cAMP response element 2 ( CRE 2 ) site , the key DNA regulatory element within the proenkephalin second messenger inducible enhancer , avidly binds AP 1 proteins , including Fos , in vitro . ^^^ Even though our striatal nuclear extracts had substantial basal and haloperidol inducible AP 1 binding activities that contained Fos , we could not detect Fos in complexes bound to the CRE 2 element . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The induction of fos and jun expression by Wy 14643 was specifically inhibited by the protein kinase C inhibitor 1 ( 5 isoquinolinesulfonyl ) 2 methylpiperizine dihydrochloride ( H 7 ) . ^^^ The activation of fos and jun gene expression by PPs was independent of peroxisome proliferation since it was an immediately early response not requiring protein synthesis and since the cell lines used in this study do not undergo peroxisome proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The DNA bends induced by the various heterodimeric complexes suggested that each component of the complex induced an independent DNA bend as previously shown for Fos and Jun . ^^^ ATF 2 also bent DNA toward the minor groove in heterodimers formed with Fos , Fra 2 , and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The high level of expression of the NQO 1 gene and its induction by beta NF and BHA require the presence of an AP 1 binding site contained within the human Antioxidant Response Element ( hARE ) and are mediated by products of proto oncogenes , Jun and Fos . ^^^ Induction of NQO 1 gene expression involves transfer of a redox signal from xenobiotics to unknown ' redox protein ( s ) ' which in turn , modify the Jun and Fos proteins for greater affinity towards the AP 1 site of the NQO 1 gene and activates transcription . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since normal Ito cells contain abundant amounts of vitamin A which is lost during activation , these data suggest that retinoids could contribute to the maintenance of the quiescent non proliferative state by suppressing mitogenesis at a post cytokine receptor step distal from or independent of fos / jun / egr [ e . g . via changes in activator protein 1 ( AP 1 ) binding ] . . ^^^ Retinoic acid suppresses the response to platelet derived growth factor in human hepatic Ito cell like myofibroblasts : a post receptor mechanism independent of raf / fos / jun / egr activation . ^^^ In addition , RAc functioned via a pathway distal or independent of cytoplasmic raf activation ( i . e . phosphorylation , kinase function and perinuclear translocation ) and nuclear fos , jun and egr expression , as these steps were similarly unaffected by RAc treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This result , taken together with data on stimulation induced changes in expression of preproenkephalin and other AP 1 transcription factors in wild type animals and stimulation induced changes in CAT activity in transgenic mice expressing portions of the proenkephalin promoter , is consistent with a role for the enhanced fos B expression in upregulation of expression of preproenkephalin in these neurons . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mutational analysis of the steroid hormone binding domain and the overlapping AP 1 site at the VDRE supports mutually exclusive occupancy by Fos Jun heterodimers and vitamin D receptor . ^^^ Such protein DNA interactions at the VDRE are consistent with repression of competency for vitamin D mediated transcriptional enhancement in proliferating osteoblasts expressing high levels of Fos and Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro binding studies revealed that , in contrast to the consensus AP 1 site which is preferentially targeted by dimers composed of the Jun and Fos families , the jun2TRE binds heterodimers composed of cJun and ATF 2 ( like ) proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transcription factor AP 1 is constituted by the products of the various fos and jun genes . ^^^ AP 1 activity is modulated by second messengers and appears to involve post translational modifications of Fos and Jun . ^^^ AP 1 activity is modulated by second messengers and appears to involve post translational modifications of Fos and Jun . ^^^ Transcription factor AP 1 is constituted by the products of the various fos and jun genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In a manner similar to that of the phorbol ester tumor promoter , TCDD induces intracellular Ca2+ changes , accumulation of FOS and JUN mRNAs , and large increases in AP 1 transcription factor activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The T cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun . ^^^ NFAT contains a subunit ( NFATp ) which is present in unstimulated T cells and which forms a complex with Fos and Jun proteins in the nucleus of activated T cells . ^^^ Purified NFATp forms DNA protein complexes with recombinant Jun homodimers or Jun Fos heterodimers ; the DNA binding domains of Fos and Jun are essential for the formation of the NFATp Fos Jun DNA complex . ^^^ The interaction between the lymphoid specific factor NFATp and the ubiquitous transcription factors Fos and Jun provides a novel mechanism for combinatorial regulation of interleukin 2 gene transcription , which integrates the calcium dependent and the protein kinase C dependent pathways of T cell activation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
When positions on either side of the hydrophobic spine of GCN 4 are diversified to include the corresponding residues of Jun , a large percentage of the resulting sequences form homodimers , and a large percentage form heterodimers with Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Many of the Ets related proteins have been shown to be transcription activators , like other nuclear oncoproteins and anti oncoproteins ( Jun , Fos , Myb , Myc , Rel , p 53 , etc . ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Evidence is provided here that the nuclear component of human NF AT contains the phorbol ester inducible transcription factor AP 1 ( Jun / Fos ) . ^^^ Antisera to Fos inhibits NF AT DNA binding as does an oligonucleotide containing a binding site for AP 1 . ^^^ Overexpression of cJun or JunD , but not JunB , also eliminates the requirement for PMA , indicating that many but not all Jun and Fos related proteins functionally activate NF AT dependent transcription in the presence of the cytoplasmic component . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun form dimeric complexes that bind to DNA sequences containing activator protein 1 ( AP 1 ) sites and regulate gene expression . ^^^ In infected chicken embryo fibroblasts ( CEFs ) , both vectors expressed similar levels of Fos protein , which formed heterodimers with Jun at equivalent efficiencies . ^^^ These results suggest that redox regulation may limit the total level of functional Fos Jun complexes in vivo and that escape from this control enhances transforming activity . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since AP 1 sites bind dimeric protein complexes composed of individual members of the Fos and Jun families of transcription factors , we used antibodies specific for individual Fos and Jun family members to determine whether they are present in the NFAT 1 binding complex . ^^^ In addition , these data indicated that specific heterodimers of Fos and Jun family members may have selective roles in the induction of transcription during cellular activation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The noncatalytic domain of a non receptor type protein tyrosine phosphatase ( the T cell phosphatase or PTP S ) isolated from a rat spleen cDNA library shows homology with the basic domains of transcription factors Fos and Jun [ Swarup , G . , Kamatkar , S . , Radha , V . , & Rema , 5 . ( 1991 ) FEBS Lett . 280 , 65 69 ] . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In vitro run off transcription and Western blot analysis revealed the expression of the protooncogenes Fos and Jun . ^^^ This suggests that Fos / Jun homo or heterodimeric complexes may interact with the 5 ' CTGCGTCAGCG 3 ' motif , present within the human CCK promoter . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Complex interactions among second messenger pathways , steroid hormones , and protooncogenes of the Fos and Jun families converge in the regulation of the nerve growth factor gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the basis of biological functions of the Fos protein , well known to be a component of a transcription factor , AP 1 , ( activator protein 1 ) a hypothesis suggesting a role of transcription factors in the integration of information during learning processes is proposed . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun proteins bind to the AP 1 consensus sequence as homodimers or heterodimers with members of the Fos protein family . ^^^ Jun proteins bind to the AP 1 consensus sequence as homodimers or heterodimers with members of the Fos protein family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos is a preferential target of glucocorticoid receptor inhibition of AP 1 activity in vitro . ^^^ We have investigated the effect of the purified glucocorticoid receptor ( GR ) DNA binding domain ( GR residues 440 to 533 [ GR 440 533 ] ) on DNA binding and transcription activation by Fos Jun heterodimers and Jun homodimers . ^^^ GR 440 533 differentially inhibited DNA binding and transcription activation by Fos Jun heterodimers . ^^^ An excess of Fos monomers protected Fos Jun heterodimers from inhibition by GR 440 533 . ^^^ Surprisingly , regions outside the leucine zipper and basic region were required for GR inhibition of Fos and Jun DNA binding . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Rapid , transient increases in the levels of c jun and jun B mRNA and protein , and in the levels of Fos related proteins ( FRAs ) , occurred in the dentate gyrus after LTP inducing tetanization of the perforant path . ^^^ The induction of c Jun , Jun B , Jun D and Fos related proteins was prevented by administration of an N methyl D aspartate receptor antagonist , which also blocked LTP induction , and by pentobarbital , which reduced but did not block LTP . ^^^ The pattern of expression of fos and jun family immediate early genes following the induction of long term potentiation ( LTP ) was investigated in the dentate gyrus of awake rats . ^^^ These findings show that differential expression of fos and jun gene family members occurs in a distinct pattern following LTP in awake rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of JUN and FOS , as well as numerous other transcription factors through the alteration of the transcription factor redox state . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Monoclonal antibodies raised against the CRE binding factors ATF 1 and CREB 1 supershifted the constitutive factors ATF 1 and CREB 1 supershifted the constitutive factor , while Jun and Fos family members , which constitute the AP 1 factor , were immunologically undetectable . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By contrast , CHX completely inhibits the induction of activator protein 1 DNA binding activity by GH , indicating that this action is secondary to the stimulation of Fos and / or Jun protein biosynthesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Myc , Fos , Jun , and Mos protein localization has been studied by immunocytochemistry in the testis of the frog , Rana esculenta , during the annual reproductive cycle . ^^^ Myc , Fos , and Jun in SPG translocate in the nucleus during the periods of active spermatogenesis . ^^^ Myc , Fos , and Jun are also localized in Sertoli cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Multiple members of the jun and fos gene families were frequently expressed at the mRNA level in vitro , with detectable functional activity ( as defined by AP 1 specific DNA binding and / or transactivation of an AP 1 driven reporter construct ) present in all 10 NSCLC cell lines examined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
For the short coiled coils , GCN 4 leucine zipper , and its fragments , Fos and Jun , very good agreement is found with experiment . ^^^ Finally , the specificity of heterodimer formation in the Fos Jun system comes from the relative instability of Fos homodimers , resulting from unfavorable intra and interhelical interactions in the interfacial coiled coil region . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 activity can also be elevated by increased expression of the Fos protein , a further AP 1 component . ^^^ Phosphorylation of Elk 1 by SAPKs and the ensuing expression of Fos protein thus constitutes an additional mechanism by which cells can upregulate AP 1 activity in response to stress . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Transactivation activity of Maf nuclear oncoprotein is modulated by Jun , Fos and small Maf proteins . ^^^ Co expression of Jun or Fos also affected the transactivation potential of Maf by forming Maf / Jun or Maf / Fos heterodimers of distinct DNA binding specificities . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factor AP 1 , made up of dimers of Fos and Jun proto oncogene products , is involved in distinct cellular processes , including cell proliferation , differentiation and apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 is an ubiquitous transcription factor which is composed of the Jun and Fos proto oncogene proteins and is thought to play a role in both cell proliferation and differentiation . ^^^ AP 1 is an ubiquitous transcription factor which is composed of the Jun and Fos proto oncogene proteins and is thought to play a role in both cell proliferation and differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The heterodimer forming leucine zippers Fos and Jun can efficiently mediate the formation of bispecific F ( ab ' ) 2 when they are fused separately to two different Fab ' fragments . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A highly conserved AP 1 element , the recognition site for members of the jun and the fos oncoproteins family , is also present in this proximal region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Numerous breast cancer cell lines showed variable levels of expression of jun and fos family member RNA , activator protein 1 ( AP 1 ) DNA binding , and transcriptional activating activities during exponential growth . ^^^ Multiple peptide growth factors as well as the tumor promoter 12 0 tetradecanoylphorbol 13 acetate induced the expression of jun and fos family member RNAs and also increased AP 1 DNA binding activity and functional AP 1 transcriptional activating activity in MCF 7 breast cancer cells . ^^^ However , treatment with estrogen , a steroid growth factor , failed to increase jun and fos RNA expression and induced minimal increases in AP 1 DNA binding and AP 1 induced transcriptional activating activity in comparison with that seen after peptide hormone treatment . ^^^ We have studied the expression and activity of the jun and fos families of transcription factors in a panel of human breast cancer cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The designed protein M ( 2 ) Gly Lys His Fos ( 138 211 ) specifically cleaves the AP 1 binding site containing DNA . ^^^ The site of cleavage by GKH Fos ( 138 211 ) on DNA provides further information regarding the bending of DNA upon binding to Fos Jun heterodimers . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrostatic interactions between charged amino acids often affect heterospecificity in coiled coils as evidenced by the interaction between the oncoproteins , fos and jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although the levels of Jun and Fos gene expression did not differ from those observed in normal fibroblasts , AP 1 binding activity , as measured by the ability to bind to an oligonucleotide containing a TPA responsive element , was significantly elevated in CL fibroblasts as compared with normal fibroblasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear extracts from LPS and zymosan treated cells showed strong AP 1 activity by gel shift analysis , and supershift analysis showed the AP 1 complexes contained specific members of both the jun and fos gene families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays identified an AP 1 binding site ( AP 1 60 ) within the proximal promoter region and evidenced differences in the pattern of the Fos family members bound to the AP 1 60 element in undifferentiated and differentiated myeloid cells , as well as between B lineage derived cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun do not bend the AP 1 recognition site . ^^^ K . & Curran , T . ( 1991 ) Cell 66 , 317 326 ] , basic region leucine zipper proteins Fos and Jun do not significantly bend their AP 1 recognition site . ^^^ Both these methods independently indicate that Fos and Jun bend their AP 1 target site by < 5 degrees , an observation that has important implications in understanding their mechanism of transcriptional regulation . . ^^^ The cyclization probabilities of DNAs with altered phasings are not significantly affected by Fos Jun binding . ^^^ Similarly , Fos Jun and Jun Jun bound to differently phased DNA constructs show insignificant variations in gel mobilities . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos Jun dimerization promotes interaction of the basic region with TFIIE 34 and TFIIF . ^^^ Here we show that the oncogenic transcription factors Fos and Jun make direct physical contacts with three proteins of the basal transcription apparatus , TFIIE 34 ( TFIIE beta ) , TFIIF 30 ( RAP 30 ) , and TFIIF 74 ( RAP 74 ) . ^^^ Both coimmunoprecipitation and protein blotting experiments demonstrated that the interactions were strongly favored by dimerization of Fos and Jun and that they involved the basic region and basic region proximal domain of both proteins . ^^^ Mutations within the DNA binding domains of Fos and Jun abolished binding to GTFs , although the presence of DNA was not required for the association . ^^^ Squelching of AP 1 dependent transcription in vitro by an excess of Fos Jun dimers was relieved by the addition of TFIIE , indicating that it is a direct functional target of Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and Fos ( AP 1 ) transcription factors were recently proposed to mediate induction of the mouse heme oxygenase 1 gene by different agents including heme and cadmium . ^^^ Jun and Fos ( AP 1 ) transcription factors were recently proposed to mediate induction of the mouse heme oxygenase 1 gene by different agents including heme and cadmium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , immunodepletion / supershift assay using antibodies directed to Fos , Jun and CREB proteins , showed that the binding activities to TRE and CRE in the nuclear extracts were derived in part from these proteins . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A truncated murine IgG 3 hinge region and a Fos or Jun leucine zipper were cloned into four scFv fragments previously isolated from a synthetic antibody phage display library . ^^^ The secreted fusion proteins were shown to spontaneously and efficiently form stable Fos Fos or Jun Jun homodimers in the Escherichia coli periplasm at levels comparable to their monovalent counterparts . ^^^ Fos and Jun homodimer ( scFv ) 2 antibodies with different specificities could be reduced , reshuffled , and reoxidized to form preparations of functional bispecific ( scFv ) 2 Fos Jun heterodimers . ^^^ These Fos and Jun fusion protein cassettes provide a universal basis for the construction of dimeric scFv antibodies with enhanced avidity or dual specificity . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel retardation assays revealed that the PDTC induced DNA protein complexes were restricted to members of the Fos and Jun families that bound to an AP 1 site located at position 60 from the transcription start site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The physical linkage of cDNA gene products to the genetic information required for their production , achieved by exploiting the high affinity interaction of the Jun and Fos leucine zippers , allows rapid and easier screening of large libraries in semifluid systems . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays with the 231 to 172 probe demonstrate JunD and Fos binding in both control and induced nuclear extracts ; however , binding of c Jun is only detected following LPS stimulation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun B , Jun D and Fos B proteins were identified as the major components of the AP 1 complex binding to the TRE element at 6 h . ^^^ Northern and Western blot analyses revealed a correlation between increased AP 1 binding activity and accumulation of jun B , jun D and fos B mRNAs and proteins . ^^^ Jun B , Jun D and Fos B proteins were identified as the major components of the AP 1 complex binding to the TRE element at 6 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 is a collection of dimeric sequence specific , DNA binding , transcriptional activators composed of Jun and Fos subunits . ^^^ AP 1 is a collection of dimeric sequence specific , DNA binding , transcriptional activators composed of Jun and Fos subunits . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We therefore conclude that induction of human NAD ( P ) H : quinone oxidoreductase by monofunctional inducers is via the ARE and not the TRE , and that the induction is mediated by proteins other than Fos and Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) is a complex of Fos and Jun , and it regulates the transcription of genes possessing the AP 1 binding sequence . ^^^ Activator protein 1 ( AP 1 ) is a complex of Fos and Jun , and it regulates the transcription of genes possessing the AP 1 binding sequence . ^^^ The Fos and Jun components of AP 1 were induced rapidly and transiently in PC 12 cells following the addition of phorbol ester ( phorbol 12 myristate 13 acetate , PMA ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , the CD 28 binding NF AT complexes do not contain Jun and Fos family proteins that have been proposed to serve as NF AT partners in the activation of the IL 2 NF AT motif . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This has important implications for the interaction of Tat with cellular proteins , specifically Fos and Jun , that contain bZIP domains . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
EMSA studies showed that the region 12 to 6 of the human IL 1 alpha promoter contains an LPS inducible AP 1 binding site composed of Jun and Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
At the nuclear level , rel , C / EBP , Ets , Egr , fos , and jun family members have been implicated in activation of LPS inducible gene expression . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The hydrophobic transmembrane regions of DRalpha and DRbeta facilitate assembly of the heterodimer and were therefore replaced by the leucine zipper dimerization motifs from the transcription factors Fos and Jun , which assemble as a soluble , tightly packed coiled coil structure . ^^^ The DRalpha Fos and DRbeta Jun constructs were expressed in a methyltrophic yeast , Pichia pastoris , using the alpha mating factor secretion signal to direct expression to the secretory pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Irradiation dramatically increased the level of the p 53 transcription factor and the abundances of mRNAs coding for the cell cycle inhibitor p21 / Waf 1 / Cip 1 and the AP 1 associated transcription factors Fos and JunB . ^^^ These results indicate that radiation elicited apoptosis of fetal brain cells is associated with activation of the p 53 system , probable increases in AP 1 Fos / JunB heterodimers , and an increased ratio of Bax to Bcl 2 + Bcl xL . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) is an inducible transcription factor , and is comprised of multiple protein complexes that include the gene products of the fos and jun gene families . ^^^ Activator protein 1 ( AP 1 ) is an inducible transcription factor , and is comprised of multiple protein complexes that include the gene products of the fos and jun gene families . ^^^ Numerous cellular and viral genes contain AP 1 binding sites within their promoters and , accordingly , AP 1 has been shown to play a role in the regulation of both basal and inducible transcription of these genes . fos related antigen 2 ( fra 2 ) has been found to have both similar and unique properties to that of other fos gene members in terms of its regulation and expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential induction of fos and jun family genes by thyrotropin in rat thyroid FRTL 5 cells . ^^^ Effect of thyrotropin ( TSH ) on the expression of the members of fos and jun family genes in a rat thyroid cell line ( FRTL 5 ) was examined by the reverse transcription polymerase chain reaction ( RT PCR ) method . ^^^ The differential induction of fos and jun family genes suggests an important role of their gene products on the regulation of thyroid cell function by TSH . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A response common to estrogen , progestins and most polypeptide mitogens is induction of the nuclear transcription factors myc , fos and jun in early G 1 phase of the cell cycle . 4 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Changes in Fos and Jun expression in the rat brainstem in the process of vestibular compensation . ^^^ By means of immunohistochemical technique , we examined the changes in Fos and Jun expression after unilateral labyrinthectomy ( UL ) in the rat brainstem . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The dopamine receptor antagonist , haloperidol , produced a time dependent differential induction of inducible transcription factors ( ITFs ) in rat striatal neurons : Fos , Fos B , Jun B , Jun D , Krox 20 , and Krox 24 , but not c Jun , were induced in the caudate putamen and nucleus accumbens with varying time courses . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , cotransfection of Fos and Jun expression vectors blunted the stimulatory effect of retinoic acid on the CYP7A / luciferase gene activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activation of muscarinic receptors also induces members of the krox as well as the fos and jun family ( jun B but not c jun ) IEGs in hippocampal neurons and this action may be involved in the facilitatory effects of muscarinic receptor activation on both hippocampal LTP and learning . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , activated ras proteins are potent inducers of the transcription factor AP 1 , which is composed of heterodimeric complexes of Fos and Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mobility shift assays with UM SCC 1 nuclear extract revealed binding of fos and junD proteins to an oligonucleotide spanning the AP 1 site at 1967 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We report that components of the AP 1 transcription factor , Fos and Jun , interact with T antigen in vitro to enhance unwinding of the viral origin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Upon treatment with LPS , H2O2 was produced , the nuclear proto oncogenes fos and jun were activated , then the HO gene was activated . ^^^ The extent of transcriptional activation of the fos , jun and HO genes in M 1 cells treated with LPS was strongly reduced by a scavenger of oxygen radicals ( N acetyl L cysteine ) , but a specific inhibitor of protein kinase C only reduced transcriptional activation by 10 20 % . ^^^ Essentially the same extends of transcriptional activation of the fos , jun and HO genes were observed as those observed after LPS treatment . ^^^ Super shift assays with DNA that contained the TRE motif revealed that the Fos and Jun proteins from nuclei of M 1 cells treated with LPS and H2O2 bound weakly to the TRE motif , and , in assays with DNA that contained the NF kappa B motif , nuclear protein from M 1 cells treated with H2O2 or LPS bound strongly to the NF kappa B motif . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Differential expression of fos and jun family members during murine postnatal intestinal development . ^^^ We have examined the patterns of expression of members of the fos and jun families of transcription factors during murine postnatal intestinal development . ^^^ Thus , modifications in expression of certain members of the fos and jun families in vivo correlate with major maturational changes during murine intestinal development and support a role for these transcription factors in the regulation of intestinal functions . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cysteine residues in the basic DNA binding domains of Jun and Fos , members of the activator protein 1 ( AP 1 ) transcription factor family , have been identified as likely targets for the therapeutic action of antirheumatic gold ( 1 ) thiolates . ^^^ The results suggest that D penicillamine is distinguished from other thiols by its formation of sulfur containing radicals capable of inhibiting AP 1 DNA binding by a mechanism involving the cysteine residues of Jun and Fos . . ^^^ Mutant proteins were used to identify the cysteine residues within the DNA binding domains of Jun and Fos that are essential for the inhibitory action of D penicillamine . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , the specific interaction between these cis elements and different combinations of Fos , Jun , and Ets proteins which recognize these sites may be important in controlling both the positive and negative regulation involved in the tissue restricted pattern of MMP expression in normal and neoplastic tissues . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous studies revealed that reduction of oxidized Fos and Jun by a cellular protein , Ref 1 , stimulates sequence specific AP 1 DNA binding activity . ^^^ This mode of regulation has been proposed to control both the transcriptional activity and the oncogenic potential of Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factors myc , jun , and fos have been characterized in both normal and transformed lung epithelial cells through detailed studies using cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun bend the AP 1 site : effects of probe geometry on the detection of protein induced DNA bending . ^^^ The effect of Fos and Jun binding on the structure of the AP 1 recognition site is controversial . ^^^ Results from ligase catalyzed cyclization experiments have been interpreted to indicate the absence of DNA bending in the Fos Jun AP 1 complex . ^^^ The analogous phase and shape dependence of the electrophoretic mobilities of the Fos Jun AP 1 complex and an intrinsic DNA bend confirm that Fos and Jun bend DNA , which may contribute to their functions in transcription regulation . . ^^^ Results from phasing analysis and phase sensitive detection studies of DNA bending by Fos and Jun have led to opposite conclusions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Promoters of many developmentally regulated genes , including osteocalcin , a marker of osteoblast differentiation , contain AP 1 sites that bind Fos / Jun dimers . ^^^ All Fos and Jun family members are involved in AP 1 complex formation in proliferating cells , whereas Fra 2 and Jun D predominate in AP 1 complexes in differentiated osteoblasts . ^^^ Coexpression of only one AP 1 pair , Fra 2 and Jun D , stimulated reporter expression , whereas coexpression of other AP 1 pairs down regulated expression ( i . e . c jun and any Fos family member ) or had no effect ( i . e . ^^^ Consistent with recent findings suggesting that AP 1 complex composition can selectively regulate gene transcription , our findings demonstrate that differential expression of Fos and Jun family members could play a role in the developmental regulation of bone specific gene expression and , as a result , may be functionally significant for osteoblast differentiation . . ^^^ Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation : role of Fra 2 and Jun D during differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Melanotransferrin gene expression in melanoma cells is correlated with high levels of Jun / Fos family transcripts and with the presence of a specific AP 1 dependent ternary complex . ^^^ By Northern analysis , we demonstrate that MTf mRNA is detected at various levels in melanoma SK MEL 28 cells and that its greatest expression coincides with the presence of large amounts of jun and fos transcripts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Various IEGs of fos , jun , and zinc finger families are differentially expressed in dorsal horn neurons in a time dependent manner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
OBJECTIVE : To identify the cells that express transcription factor NF kappa B subunits p 50 and p 65 in synovial tissue from patients with rheumatoid arthritis ( RA ) and to correlate the distribution of p 50 and p 65 with CD 14 ( macrophage lipopolysaccharide receptor ) and members of the AP 1 transcription factor family , Jun and Fos . ^^^ Different but overlapping distributions of nuclear p 50 and p 65 versus Jun and Fos indicate separate or divergent mechanisms for the activation of NF kappa B and the expression of AP 1 proteins in rheumatoid synovium . . ^^^ METHODS : Immunohistochemistry was used to identify p 50 , p 65 , Jun and Fos in sections of synovial tissue from 13 patients with RA and 4 `` normal ' ' control subjects . ^^^ Jun and Fos were present in the nuclei of a large proportion of synovial lining cells with significantly less expression elsewhere . ^^^ In each case the Jun / Fos distribution was clearly different from the p50 / p65 distribution , although there was significant overlap in many cases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously described a dominant negative mutant of cJun that lacks the transactivation domain ( TAD ) of cJun and prevents AP 1 mediated transcriptional activation by quenching endogenous Jun or Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although many studies with UVC and UVB radiations involve lethal doses , it is clear that these radiations have the property of mimicking growth factor responses and stimulate various signal transduction pathways that lead to gene activation including transcriptional activation of the jun and fos proto oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of proteins coded by the immediate early genes of the fos family and c jun was used to study the effect of acute ethanol administration on convulsant induced neuronal activity in rat brain . ^^^ In contrast , N methyl D aspartic acid induced FOS immunoreactivity in the hippocampus was not inhibited by any dose of ethanol . c JUN immunoreactivity showed a distinct pattern of induction in the hippocampus after injection of N methyl D aspartic acid . ^^^ FOS and JUN as markers for ethanol sensitive pathways in the rat brain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Upon treatment with TPA , H2O2 was produced first , the nuclear proto oncogenes fos and jun were activated , and then the HO gene was activated . ^^^ The extent of transcriptional activation of the fos , jun , and HO genes in M 1 cells treated with TPA was reduced by a specific inhibitor of C kinase and a scavenger of oxygen radicals . ^^^ When M 1 cells were treated with H2O2 , essentially the same level of transcription of the HO gene was observed , but the extent of transcriptional activation of the fos and jun genes was about half of the treatment with TPA . ^^^ Super shift assays using the TRE of the HO gene revealed that the Fos and Jun proteins from nuclei of M 1 cells treated with TPA bound to the TRE , and same assays using DNA with the NF kappa B motif also revealed that the active NF kappa B protein from M 1 cells treated with H2O2 or TPA also bound to the corresponding motif . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Based on the fact that synovial lining cells have some properties of transformed appearing cells , we have examined the expression of Myc , Myb , Fos , Jun and Ras oncoproteins in synovial tissues from patients with different types of arthritis . ^^^ The expression of Myc , Myb , Fos and Jun was significantly correlated both to the degree of synovial hypercellularity and the synovial lymphocytic infiltration . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MKP 1 may contribute in the specific subpopulations where it is induced to the post translational control of inducible transcription factors of the fos , jun and myc family . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , overexpression and constitutive nuclear localization of NF AT , but not Jun , Fos , NF kappaB , Oct or Ets family members , renders the interleukin 2 enhancer in Jurkat T lymphocytes resistant to FK 506 and cyclosporin A . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Temporal relationship between the expression of fos , jun and krox 24 in the guinea pig vestibular nuclei during the development of vestibular compensation for unilateral vestibular deafferentation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This inhibition results , at least in part , from RA induced decreases in the mRNA for the transactivators Fos and Jun ( with concominant increases in RAR mRNA ) and by sequestration of Fos / Jun by RARs / RXRs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate two unresolved issues in the initiation of signaling , the role of receptor extracellular domains and receptor stoichiometry , we replaced the mouse GM Ralpha and GM Rbeta extracellular domains with the leucine zipper domain of either the Fos or Jun molecule . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , glucocorticoid hormones repress transcription of the collagenase gene by the interaction of glucocorticoid receptors with the AP 1 proteins , Fos and Jun . ^^^ Retinoids also suppress transcription by mechanisms that involve down regulation of fos and jun mRNA , sequestration of Fos and Jun proteins , and the formation of complexes of retinoic acid receptors ( RAR / RXR heterodimers ) and AP 1 proteins on the DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This motif binds Oct 1 and Oct 2 as well as the phorbol ester and calcium ionophore inducible jun and fos AP 1 factors . ^^^ PGE 2 does not regulate octamer function by influencing the jun and fos mRNA or Oct 1 protein levels or their DNA binding abilities . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While isoproterenol treatment increased steady state mRNA levels for fos , jun , myc , src , c erbB 2 , ras and topo 2 , inclusion of pefloxacin with the isoproterenol regimen blocked these increases . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this investigation , untreated non B type acute lymphoblastic leukemia ( ALL ) of 104 children was analyzed using immunocytochemistry for expression of protein kinase C , proto oncogene products ( Fos , Jun , Ras ) and resistance related proteins ( topoisomerase 2 , P glycoprotein , glutathione S transferase pi , metallothionein , dihydrofolate reductase , thymidylate synthase ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Twenty tumoral and peritumoral tissues from patients with lung cancer were analyzed immunohistochemically for the drug resistance related proteins P glycoprotein ( P 170 ) , topoisomerase 2 ( Topo 2 ) , glutathione S transferase pi ( GST pi ) , metallothionein ( MT ) , heat shock protein 70 ( HSP 70 ) and the putative regulators of resistance ( ErbB 1 , Fos and Jun ) . ^^^ Protein expression of Topo 2 , GST pi , MT , HSP 70 , ErbB 1 , Fos and Jun was elevated in tumor tissue in comparison to normal tissue . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oncogenes which activate ras signal transduction pathways stimulate expression of the K 18 gene through transcription factors including members of the AP 1 ( jun and fos ) and ETS families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Evidence from a synthetic peptide model suggests that TodS binds as a dimer to a pseudopalindromic sequence ( 5 ' TGACTCA ) , which resembles the recognition sequence of the eukaryotic transcription factors Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun expression in rat supraoptic nucleus neurons after acute vs . repeated osmotic stimulation . ^^^ Using a double label immunofluorescence method , we analyzed the time course of the appearance of Fos and Jun in the nuclei of supraoptic nucleus ( SON ) neurons following intraperitoneal injection of hypertonic saline . ^^^ Fos and Jun immunostaining appeared within 30 min , peaked at 90 120 min , and disappeared 4 5 h later . ^^^ At all time points ( 30 , 60 , 120 , 180 , 240 min postinjection ) , colocalized Fos and Jun immunostaining was observed ( > 90 % colocalized staining in labeled neurons ) . ^^^ A second injection of normal saline resulted in no Fos / Jun immunostaining 90 min later , while hypertonic saline induced combined Fos / Jun staining in only 17 % of SON neurons . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To analyse the potential link betwen AP 1 activity , encoded by members of the jun and fos gene families , and Ras mediated cellular transformation , we have studied several NIH3T3 clones which overexpress the Ha Ras or Ki Ras oncogenes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The following oncogenes were examined : ras family ( c H , c N , and c K ras ) , early genes ( fos , jun ) , and tumor suppressor genes ( p 53 and nm 23 H 1 ) . ^^^ Our findings suggest that the ras family of oncogenes , fos and jun oncogenes , and nm 23 and p 53 tumor suppressor genes are present in congenital SCT , indicating a possible role in genesis and development of these tumors . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays using specific antibodies to Jun and Fos demonstrated the participation of both proteins in the binding activities generated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We compared the efferent fiber distributions anterogradely traced from these sites to the distributions of striatal neurons activated by microstimulation to express Fos and Jun B like immediate early gene proteins . ^^^ We show that the microstimulation of sensorimotor cortex induces Fos and Jun B expression in localized cell clusters in the putamen and that these clusters match the anatomical input fiber clusters ( matrisomes ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 ( activating protein 1 ) is a collective term referring to dimeric transcription factors composed of Jun , Fos or ATF ( activating transcription factor ) subunits that bind to a common DNA site , the AP 1 binding site . ^^^ In addition to regulation by heterodimerization between Jun , Fos and ATF proteins , AP 1 activity is regulated through interactions with specific protein kinases and a variety of transcriptional coactivators . . ^^^ AP 1 ( activating protein 1 ) is a collective term referring to dimeric transcription factors composed of Jun , Fos or ATF ( activating transcription factor ) subunits that bind to a common DNA site , the AP 1 binding site . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of MT leads to increased AP 1 ( Fos / Jun ) transcriptional complex activity . ^^^ Wild type and mutant polyomavirus middle T ( MT ) overexpressing cell lines , generated with retroviral vector constructs , were used to investigate the role played by peptide growth factor primary response genes ( fos , jun , myc , JE , KC ) in viral transformation and to map the transduction pathway of the mitogenic signal of MT . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reconstruction experiments using leucine zippers from GCN 4 , Jun , Fos , and C / EBP showed that this assay distinguishes pairs that form heterodimers from those that do not . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of genes for all the other known members of chicken AP 1 , which include such transforming genes as c jun and fra 2 , however , caused no macroscopic abnormalities in limb formation , indicating a specific function of Fos proteins in embryonic endochondral bone differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western and supershift analyses indicated that functional Jun and Fos proteins were present in nuclear extracts of PMA differentiated U 937 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have recently demonstrated that CR asthma is associated with decreased GR and increased AP 1 ( Fos ; Jun ) DNA binding in peripheral blood mononuclear cells as compared to corticosteroid sensitive asthma . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To precisely analyze the P 2 binding factors we used antibodies against NF ATp , NF ATc , Fos , Jun , Oct 1 and Oct 2 in EMSA . ^^^ The PMA / ionomycin inducible complex contains NF ATp / c , Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To investigate the PMA dependent effect on proteinase secretion in more detail , we have now analysed the role of a downstream transmitter of PKC activity in this process , namely Fos , which is part of the AP 1 transcription factor in the nucleus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we examine the effects of single amino acid substitutions adjacent to the basic regions of Fos and Jun as well as changes in sequences flanking the AP 1 site on DNA bending . ^^^ These results suggest that Fos and Jun induce DNA bending in part through electrostatic interactions between amino acid residues adjacent to the basic region and base pairs flanking the AP 1 site . ^^^ DNA bending by Fos and Jun at inverted binding sites indicated that heterodimers bind to the AP 1 site in a preferred orientation . ^^^ Mutation of a conserved arginine within the basic regions of Fos and transversion of the central C : G base pair in the AP 1 site to G : C had complementary effects on the orientation of heterodimer binding and DNA bending . ^^^ The conformational variability of the Fos Jun AP 1 complex may contribute to its functional versatility at different promoters . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This FGF inducible response element ( FiRE ) consists of a 170 bp array of five DNA motifs which bind two FGF inducible Fos Jun heterodimers , one inducible AP 2 related protein , a constitutively expressed upstream stimulatory factor , and one constitutive 46 kDa transcription factor . ^^^ They activate a number of genes , including immediate early genes , such as the transcription factors Fos and Jun , which are also common targets for other tyrosine kinase receptor activating growth factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of some PDGF primary response genes ( fos , jun , myc , JE , KC ) was shown to be rendered constitutive by MT overexpression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions . ^^^ We show that the transcription activation domains of Fos and Jun induce DNA bending . ^^^ Therefore , the opposite directions of DNA bending by Fos and Jun are caused , in part , by the opposite locations of the transcription activation domains relative to the DNA binding domains in these proteins . ^^^ DNA bending is reduced in the presence of multivalent cations , indicating that electrostatic interactions contribute to DNA bending by Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNA bending by Fos Jun and the orientation of heterodimer binding depend on the sequence of the AP 1 site . ^^^ We show that Fos and Jun induce distinct DNA bends at different binding sites , and that heterodimers bind to AP 1 sites in a preferred orientation . ^^^ Substitution of sequences flanking the AP 1 site has converse effects on DNA bending in opposite directions , suggesting that the extent of DNA bending by Fos and Jun is determined in part by the anisotropic bendability of sequences flanking the AP 1 site . ^^^ The preferred orientation of heterodimer binding is determined both by contacts between a conserved arginine in the basic region of Fos and the central asymmetric guanine as well as the structure of sequences flanking the AP 1 site . ^^^ Consequently , the structural adaptability of the Fos Jun AP 1 complex may contribute to its functional versatility at different promoters . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Chicken embryo fibroblasts ( CEF ) transformed with 5 src were previously reported to revert to normal phenotype after the introduction of dominant negative mutants of Fos or Jun , indicating that endogenous AP 1 activity is essential for the cellular transformation . ^^^ The major changes in the expression levels of fos and jun family genes induced by 5 src were the elevation of fra 2 and c jun transcripts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Many factors affect the formation and activity of AP 1 dimers ( Fos and Jun heterodimers ) through protein specific interactions or by the modulation of pre existing complexes by phosphorylation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Based on nucleotide sequence requirements and immunoreactivity , we demonstrate that this DNA protein complex is comprised of the AP 1 components , Fos and Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 is a heterodimer of the oncogenes Fos and Jun , members of the bZIP family of transcription factors . ^^^ Expression of A Fos in mouse fibroblasts inhibits focus formation more than colony formation , reflecting the ability of A Fos to interfere with the AP 1 biological functions in mammalian cells . ^^^ This reagent is more potent than a deletion of either the Fos or Jun transactivation domain , which has been used previously as a dominant negative to AP 1 activity . . ^^^ AP 1 is a heterodimer of the oncogenes Fos and Jun , members of the bZIP family of transcription factors . ^^^ Gel shift assays indicate that A Fos can inactivate the DNA binding of a Fos : Jun heterodimer in an equimolar competition . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the 5 ' upstream region of the EDN 1 gene , AP 1 and NF 1 elements were found , suggesting the possibility that the expression of swine EDN 1 gene is controlled by protooncogene products Fos and Jun , and TGF beta . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays , using Jun and Fos family member specific antibodies , showed that protein complexes formed by AtT 20 cell nuclear extracts bound to the c jun AP 1 site were comprised of Jun family members , JunD , JunB , and cJun . ^^^ No clear association of Fos family members with the c jun AP 1 site could be demonstrated . ^^^ Pan Jun and pan Fos antibodies were able to supershift protein CRE complexes formed using NIH 3T3 nuclear extracts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To study the effects of in vivo pancreatic stimulation with cerulein , we analyzed the expression of the protooncogenes jun , myc , and fos on the mRNA and protein levels . ^^^ In conclusion , ( 1 ) acinar cells in the rat pancreas respond to cerulein stimulation by increasing the expression of jun ; ( 2 ) in vivo high doses of cerulein increase the jun mRNA and jun protein levels , whereas low doses raise only the protein levels ; and ( 3 ) myc and fos are apparently uninfluenced by cerulein administration . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Comparison of DNA bending by Fos Jun and phased A tracts by multifactorial phasing analysis . ^^^ Studies of DNA bending by Fos and Jun using different methods have yielded contradictory results . ^^^ Whereas gel electrophoretic phasing analysis indicates that Fos and Jun bend DNA , results obtained through 10 ray crystallography and ligase catalyzed cyclization suggest that they do not . ^^^ To test the assumptions underlying phasing analysis and to examine DNA bending by Fos and Jun , a multifactorial phasing analysis approach based on the distinct electrophoretic mobilities of DNA fragments of diverse shapes was developed . ^^^ Complexes formed by the bZIP domains of Fos and Jun fulfilled each of these criteria . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since AP 1 is part of the NFAT complex , we conclude that the IL 7 signaling pathway is involved in the activation of the fos and jun proteins of which AP 1 consists . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Likewise , replacement studies with an AP 1 element that binds heterodimers of jun and fos indicated that this element was incapable of compensating for either the tandem CRE or JRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , p 80 transformed cells showed elevated expression of several immediate early genes involved in cellular proliferation , including fos , jun , and c myc . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Thus , in addition to its known role as a transcriptional activator of the cellular heat shock response , heat shock factor 1 also antagonizes the expression of Fos , a key component of the ubiquitous AP 1 transcription factor complex and as such could influence multiple aspects of cell regulation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear extracts from PC 12 cells display a cAMP induced complex binding to the DB 1 element , and antisera to transcription factors CREB , CREM , Fos , and Jun indicate that these proteins , or closely related family members , interact with DB 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Drosophila melanogaster genomic sequences homologous to the mammalian oncogenes ras , src , jun , fos , ets , and wnt are considered . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
D Fos is shown to act in a similar manner to Drosophila Jun : in the cells of the leading edge it is required for the expression of the TGFbeta like Decapentaplegic ( Dpp ) protein , which is believed to control the cell shape changes that take place during dorsal closure . ^^^ These results indicate that D Fos is required downstream of the Drosophila JNK signal transduction pathway , consistent with a role in heterodimerization with D Jun , to activate downstream targets such as dpp . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of JUN and FOS , HeLa AP 1 , and numerous other transcription factors , including Myb , members of the CREB family and nuclear factor kappa B . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of AP 1 DNA binding by nitric oxide involving conserved cysteine residues in Jun and Fos . ^^^ Cysteine to serine mutants showed that the inhibition of AP 1 activity following NO treatment was dependent on the presence of Cys 7272 and Cys 154 in the DNA binding domain of Jun and Fos , respectively . ^^^ Since DNA binding of Jun Jun and Jun Fos dimers is regulated in vitro by redox control involving conserved cysteines , we hypothesized that the action of NO is mediated via these residues . ^^^ We performed electrophoretic mobility shift analyses using Jun and Fos recombinant proteins and NO solutions . ^^^ Our results demonstrate that NO mediates its inhibitory effect by reacting specifically with the conserved cysteine residues in Jun and Fos . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos and Jun family proteins were identified as components of the DNA protein complexes by anti peptide antibodies in gel supershift assays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Other D N inhibitors generated in a similar manner with the dimerization domains of Fos , Jun , C / EBP , ATF 2 , or VBP did not block CREB DNA binding activity , nor did they inhibit transcriptional activation of a minimal promoter containing a single CRE in PC 12 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ability of Fos / Fra proteins to participate in a transcriptional complex was confirmed in gel shift experiments with an AP 1 element , and the biphasic trend of binding activity was observed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Jun protein appears only in 3 h after the onset of lymphocyte activation ; this suggests independent participation of Fos in the early stages of lymphocyte activation prior to the appearance of Jun , preceding the joint action of Fos and Jun within the AP 1 transcription complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos protein is shown to be a component of the activated AP 1 complex , as determined by supershift analysis , suggesting that it consists of Jun / Fos heterodimers . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrate the use of a DNA minicircle competition binding assay , together with DNA cyclization kinetics and gel phasing methods , to show that the DNA binding domains ( dbd ) of the heterodimeric leucine zipper protein Fos Jun do not bend the AP 1 target site . ^^^ Competition binding experiments reveal that ( dbd ) Fos Jun has a slight preference for binding to linear over circular AP 1 DNAs , independent of whether the site faces in or out on the circle . ^^^ A single A tract bend replacing the AP 1 site is readily detected by its effect on cyclization kinetics , in contrast to the observations for Fos Jun bound at the AP 1 locus . ^^^ In contrast , comparative electrophoresis reveals that Fos Jun DNA complexes , in which the A tract bend is positioned close ( 1 2 helical turns ) to the AP 1 site , show phase dependent variations in gel mobilities that are comparable with those observed when a single A tract bend replaces the AP 1 site . ^^^ DNA binding domains of Fos and Jun do not induce DNA curvature : an investigation with solution and gel methods . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The after discharge produced a rapid ( after 1 h ) increase in Fos , Jun B , c Jun , Krox 24 mRNA and protein and Krox 20 protein in dentate granule neurons and a delayed , selective expression of Fos , Jun D and Krox 24 in hilar interneurons . ^^^ MK 801 pretreatment produced a very strong inhibition of Fos , Jun D and Krox 20 increases in dentate neurons but had a much smaller effect on Jun B and c Jun expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This transcription factor is composed of products from the fos and jun proto oncogene family and is believed to be important in regulating cell growth and proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Prognostic value of ERBB 1 , VEGF , cyclin A , FOS , JUN and MYC in patients with squamous cell lung carcinomas . ^^^ For this reason , immunohistochemistry was used to examine the squamous cell lung carcinomas from 121 patients for their expression of ERBB 1 , vascular endothelial growth factor ( VEGF ) , cyclin A , FOS , JUN and MYC . ^^^ Median survival was shorter for patients with ERBB 1 , VEGF , cyclin A , FOS , or JUN positive tumours . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Ref 1 protein is a bifunctional nuclear enzyme involved in repair of DNA lesions and in redox regulation of DNA binding activity of AP 1 family members , such as Fos and Jun transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
DNA bending and the curious case of Fos / Jun . ^^^ For the Fos and Jun transcription factors , this has resulted in controversy over whether these factors significantly bend DNA at all . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This tyrosine kinase phosphorylates a number of intracellular substrates that activates pathways leading to cell growth , DNA synthesis and the expression of oncogenes such as fos and jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear factor of activated T cells ( NFAT ) and the AP 1 heterodimer , Fos Jun , cooperatively bind a composite DNA site and synergistically activate the expression of many immune response genes . ^^^ A 2 . 7 A resolution crystal structure of the DNA binding domains of NFAT , Fos and Jun , in a quaternary complex with a DNA fragment containing the distal antigen receptor response element from the interleukin 2 gene promoter , shows an extended interface between NFAT and AP 1 , facilitated by the bending of Fos and DNA . ^^^ Structure of the DNA binding domains from NFAT , Fos and Jun bound specifically to DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The GF induced hepatocellular proliferation was mediated through activation of immediate early genes such as Fos , Jun , Myc , and NFKB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Enhanced Jun activity is likely to target several different genetic programs as Jun forms heterodimers with one of several members of the Fos and ATF 2 subfamilies , resulting in transcription factors with different sequence specificities . ^^^ Upon introduction into CEFs , a Jun mutant selective for the Fos family induced anchorage independent growth but no growth factor independence . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We found that a dimer of this site fused to a minimal uPA CAT fusion gene was responsive to 1 mM 8 BrcAMP ( 100 % CAT increase ) , not responsive to 100 nM tRA , and synergistically responsive to 100 nM tRA+1 mM 8 BrcAMP ( 240 % CAT increase ) in cells co transfected with Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We determined the specificities of heterodimer formation with all members of the Jun and Fos family . ^^^ In contrast to 5 Maf which forms heterodimers with all Jun and Fos proteins , Maf 1 heterodimerizes with all four Fos proteins , but not at all with the three Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Distribution of Fos and Jun related proteins and activator protein 1 composite factors in mouse brain induced by neuroleptics . ^^^ We immunocytochemically investigated the expression of Fos and Jun related proteins and examined activator protein 1 DNA binding activity in ddY mouse brain 120 min after the administration of haloperidol ( 1 mg / kg ) , ( ) sulpiride ( 20 mg / kg ) and a selective dopamine D 1 receptor antagonist , SCH 23390 ( 1 mg / kg ) . ^^^ These results suggested that induced Fos , FosB , Fra 1 , Jun and JunD proteins constitute the activator protein 1 complex after the administration of haloperidol and sulpiride . ^^^ The densities of Fos , FosB , Fra 1 , Jun and JunD immunoreactive nuclei induced by haloperidol and sulpiride in the hippocampus , piriform cortex and accumbens nucleus were higher than those in the control groups . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One copy of MeIARV was found to be inserted at the end of the 6th leucine domain of the c maf proto oncogene , which encodes a basic region / leucine zipper transcription factor related to the AP 1 family that is able to form homodimers or heterodimers with Fos and Jun transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , collagen induces a time dependent increase in the DNA binding activity of the activator protein 1 , which is well correlated with an increase in Fos expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This up regulation is accompanied by an increased binding of jun and fos family members to a consensus AP 1 binding site of the proximal ( 16 ) CD 69 promoter region , which seems to be functionally responsive to different activation signals and is trans activated by c jun expression vectors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The present work was designed ( a ) to study comparatively the effect of 2Hz and 100Hz electroacupuncture ( EA ) on the expression of oncogene c fos / c jun and three opioid ( preproenkephalin PPE ; preprodynorphin PPD ; proopiomelanocortin POMC ) genes in the rat brain ; ( b ) to clarify the role of Fos / Jun ( AP 1 ) on opioid genes expression induced by EA stimulation through specific blockade of EA induced Fos / Jun expression using antisense oligodeoxynucleotides ( ODNs ) of c fos / c jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has also revealed that the level of fos , a component of the AP 1 transcription factor , decreases with age , which has implications for AP 1 regulated genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Alterations in levels of the immediate early gene ( IEG ) proteins Fos , FosB , DeltaFosB , Jun , JunB , JunD , and NGFI A were investigated in rat hippocampus by immunohistochemistry 2 , 12 , 24 , and 48 h after forebrain ischemia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Regulation of gene activation by the estrogen receptor ( ER ) is complex and involves co regulatory proteins , oncoproteins ( such as Fos and Jun ) , and phosphorylation signaling pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have investigated the roles of two elements of the TH promoter , the TH ' Fat Specific Element ' ( TH FSE ) which binds the Fos Jun complex , and the cAMP Response Element ( CRE ) , which binds CREB and the co activator protein , CREB Binding Protein ( CBP ) in regulating TH gene transcription . ^^^ In F 9 cells , the TH promoter was strongly activated by Fos and Jun , and by PKA stimulated CREB protein . ^^^ In F 9 and NIH3T3 cells , CBP , a co activator which targets Fos Jun and PKA stimulated CREB , also induced the TH promoter . ^^^ Immunohistochemical studies in rat brain regions enriched in dopaminergic neurons , including the midbrain and olfactory bulb ( OB ) , suggest that Fos Jun and CREB make differential contributions to TH gene activity in different tissues . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ap 1 proteins such as Fos and Jun are nuclear transcription factors that have been postulated to function as third messengers in signal transduction pathways to regulate target gene expression . ^^^ Analysis of AP 1 binding activity in both hypothalamus and pituitary by supershift , immunodepletion and shift Western blot indicated that part of the AP 1 binding was due to the presence of Fos and Jun proteins . ^^^ Ap 1 proteins such as Fos and Jun are nuclear transcription factors that have been postulated to function as third messengers in signal transduction pathways to regulate target gene expression . ^^^ However , Western blot analysis shows that the levels of Fos and Jun proteins in the hypothalamic nuclear extracts were not altered by E treatment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Both DNA binding and transactivation of AP 1 and NF kappaB transcription factors showed elevation in the anchorage independent ( 16RH ) and tumorigenic ( 18 5 fos ) keratinocyte lines compared to the less progressed but immortalized cell lines . ^^^ Blocked shift / supershift analysis indicates that Fos family member proteins especially Fra 1 and Fra 2 are related to progression and no changes found in the Jun family member proteins although they are present in the AP 1 / DNA binding complex . ^^^ When a dominant negative mutant c jun driven by a human keratin 14 promoter was co transfected with AP 1 or NF kappaB reporters , both AP 1 and NF kappaB activities were suppressed in the more progressed cell lines 16RH and 18 5 fos but not in the less progressed 16RL or 18 cell lines . ^^^ Stable transfectants of this mutant c jun in the two more progressed cell lines 16RH and 18 5 fos showed reduced AP 1 and NF kappaB activation and reduced anchorage independent growth . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Some of these downregulated IEGs encode Fos related components of the activator protein 1 ( AP 1 ) complex , which is likely re regulate a number of genes important for neuronal function . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Modulation of Fos mediated AP 1 transcription by the promyelocytic leukemia protein . ^^^ There is significant sequence homology between the dimerization domain of PML and the Fos family of proteins , which imply that PML may be involved in AP 1 activity . ^^^ Here we show that PML can cooperate with Fos to stimulate its AP 1 mediated transcriptional activity . ^^^ This study demonstrated that PML is involved in the AP 1 complex and can modulate Fos mediated transcriptional activity , which may contribute to its growth suppressor function . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MafA is able to bind to MARE sequence and to heterodimerize with 5 Maf , MafB , Jun and Fos , but not with the small MafF and MafK proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , we show that the formation of the previously described ternary complex Ergp55 / Fos / jun is mediated by ETS domain and Jun protein , while the ternary complex Ergp49 / Fos / Jun is mediated by Fos protein . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using insect cells , we expressed large quantities of soluble human integrin alpha 3 beta 1 ectodomain heterodimers , in which cytoplasmic and transmembrane domains were replaced by Fos and Jun dimerization motifs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using a purified CREB fusion protein , a novel dye label technique , and sedimentation equilibrium analysis , we directly and conclusively demonstrate that , unlike Jun and Fos , CREB dimerization is DNA dependent . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AT 1 receptor mediated regulation of certain signaling events ( such as activation of the Ras Raf 1 mitogen activated protein ( MAP ) kinase signaling pathway , nuclear translocation of transcription factors such as Fos and Jun , and the interactions of these factors with AP 1 binding sites ) is involved in this NE neuromodulation ( Lu et al . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Upregulation of Jun and Fos family members and permanent JNK activity lead to constitutive AP 1 activation in Theileria transformed leukocytes . ^^^ Thus , constant AP 1 transcriptional activity involves both an upregulation in the levels of Jun and Fos proteins and constitutive JNK activation . . ^^^ Parasite infection leads to an up regulation of all members of the Jun / Fos family of proteins and surprisingly , this occurs in the absence of any detectable ERK , or p 38 MAP kinase activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Soluble HLA DR 2 was expressed in the baculovirus system by replacing the hydrophobic transmembrane regions and cytoplasmic segments of DRalpha and DRbeta with leucine zipper dimerization domains from the transcription factors Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We investigated whether osmotic stress in vivo or muscarinic ACh receptor activation in vitro changed the expression levels of the cellular protooncogene products Fos and Jun , which may play a role in the initiation of the adaptive processes . ^^^ Using Fos and Jun specific polyclonal antisera in Western blot experiments , we demonstrated that Jun is constitutively expressed in nasal gland tissue , whereas Fos is not detectable in tissue from unstressed ( naive ) animals . ^^^ Under conditions of osmotic stress imposed by replacing the drinking water of the animals with a 1 % NaCl solution , Jun protein remains constant in nasal gland tissue , whereas Fos protein is transiently upregulated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of AP 1 and C / EBP binding and in the expression of c jun and c myc mRNA in the first 4 hours after PH , as well as the apparent lack of Fos in AP 1 complexes , had no effect on the timing or extent of DNA replication . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Simultaneously , the construct was designed to form specific heterodimers by inclusion of the well known leucine zipper motiv of Jun and Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have determined the orientation of Fos Jun binding at different AP 1 sites using a novel gel based fluorescence resonance energy transfer assay . ^^^ DNA bending determines Fos Jun heterodimer orientation . ^^^ Single amino acid substitutions that reduce the difference in DNA bending between Fos and Jun also reduced the orientation preference . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As GnRH is a major regulator of FSHbeta expression and is also known to stimulate the synthesis of Jun and Fos family members ( AP 1 ) , we investigated the possibility that oFSHbeta transcription may be regulated by GnRH through AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Discordant effects of activator protein 1 transcription factor on gene regulation , invasion , and metastasis in spontaneous , radiation induced , and fos induced osteosarcomas . ^^^ Bone cells are a prime target for the biological function of the fos / jun ( activating protein 1 ( AP 1 ) ) transcription factor complex . ^^^ Here we compared the expression of AP 1 dependent genes and AP 1 activity in cell lines from fos induced , radiation induced , and spontaneous osteosarcomas . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Expression of PAX 5 was limited to those cells which also expressed the oncogenes myc , fos , or jun singularly or in combination . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition to its ability to activate transcription from androgen response elements , AR can inhibit activator protein 1 ( AP 1 ) activity , composed of Jun and Fos oncoproteins , in a ligand dependent manner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activating protein 1 ( AP 1 ) , a dimeric complex consisting of proteins encoded by the Jun and Fos gene families , is a transcription factor induced by a variety of signals , including those eliciting proliferation , differentiation and programmed cell death ( apoptosis ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Mutation of a critical Arg residue in the basic leucine zipper domain of either Fos or Jun yielded single point mutant heterodimers that bind DNA in a single defined orientation , as determined directly by native chemical ligation / affinity cleavage ; by contrast , the corresponding wild type protein binds DNA as a roughly equal mixture of two isomeric orientations , which are related by subunit interchange . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Targeting of the visna virus tat protein to AP 1 sites : interactions with the bZIP domains of fos and jun in vitro and in vivo . ^^^ AP 1 sites within the visna virus LTR , which can be bound by the cellular transcription factors Fos and Jun , are also necessary for Tat mediated transcriptional activation . ^^^ A potential mechanism by which the visna virus Tat protein could target the viral promoter is by protein protein interactions with Fos and / or Jun bound to AP 1 sites in the visna virus LTR . ^^^ AP 1 sites within the visna virus LTR , which can be bound by the cellular transcription factors Fos and Jun , are also necessary for Tat mediated transcriptional activation . ^^^ To examine protein protein interactions with cellular proteins at the visna virus promoter , we used an in vitro protein affinity chromatography assay and electrophoretic mobility shift assay , in addition to an in vivo two hybrid assay , to show that the visna virus Tat protein specifically interacts with the cellular transcription factors Fos and Jun and the basal transcription factor TBP ( TATA binding protein ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The pJuFo phage display system , based on the interaction between the leucine zippers Jun and Fos , has been modified and used to create a genomic phage display library from Escherichia coli MG 1655 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Structure and transcriptional regulation of BKJ , a novel AP 1 target gene activated during jun or fos induced fibroblast transformation . ^^^ We now show that BKJ is a direct transcriptional target of the AP 1 transcription factor components Jun and Fos . ^^^ Activation of BKJ in fibroblasts by retroviral or deregulated cellular jun or fos alleles may contribute to cell transformation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos and Jun oncoproteins form dimeric complexes that stimulate transcription of genes containing activator protein 1 regulatory elements . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 components Jun and Fos were also present in the intimal lining and was significantly greater in RA than OA . ^^^ AP 1 components Jun and Fos were also present in the intimal lining and was significantly greater in RA than OA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos B was found to be the exclusive member of the Fos family present in the TH AP 1 complex . ^^^ These results indicated that Fos B , acting through both AP 1 and CRE motifs , may be implicated in the regulation of TH expression in the olfactory bulb dopaminergic neurons . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fusion of Jun and Fos to the constant domains also decreased the folding yield , because of premature association of intermediates leading to aggregation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In situ DNA fragment labelling and immunocytochemical analysis of these tumours reveals that they display enhanced levels of apoptosis , which is associated with elevated levels of Myc , Fos , Jun , and p 53 protein expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Absence of activity of AP 1 family transcription factors ( the products of early fos and jun genes in juvenile snails belong to AP 1 family ) may underlie the incapability for sensitization and avoidance conditioning in juvenile snails . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun and Fos family protein levels have been found not to be limiting for AP 1 response . ^^^ Jun and Fos family protein levels have been found not to be limiting for AP 1 response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Uncoiling c Jun coiled coils : inhibitory effects of truncated Fos peptides on Jun dimerization and DNA binding in vitro . c Jun is an oncoprotein that comprises a portion of the AP 1 transcription factor and belongs to the basic leucine zipper ( bZIP ) DNA binding protein family . ^^^ Fos peptides that were effective inhibitors in the DNA binding assay were also found to inhibit cellular Jun binding to an AP 1 site in a luciferase reporter plasmid in MCF 7 cells . ^^^ Using peptides derived from the leucine zipper region of Fos , we have developed agents that inhibit Jun ' s DNA binding in the low micromolar range . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays revealed binding of Jun and Fos to AP 1 and CRE sequences and binding of activating transcription factor 2 to CRE . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The MDV genes currently thought to be involved in lymphomagenesis include a bZIP transactivator that is homologous to fos and jun oncogenes but do not appear to have counterparts in other oncogenic herpesviruses . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As Ca2+ signals are short lived when compared to alterations in differentiated gene expression , it is generally considered that genes coding for short lived transcription factors ( i . e . fos , jun ) are the immediate target of Ca2+ signalling . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Changes in proto oncogene expression , determined by measuring Fos , Jun , and Myc mRNA levels as well as by the DNA binding activity of the AP 1 , AP 2 and NF kappaB transcription factors , were used as indicators of a general stress response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effects of chronic hypoxia on the expression of oncogene jun fos and myb mRNA in rat lung ] . ^^^ This paper is to investigate the expression of oncogene jun fos and myb mRNA in the lung of rats exposed to chronic hypoxia . 15 SD rats were put in low oxygen chamber ( FiO 2 = 0 . 1 ) , 8 hrs daily for 1 , 2 and 3 weeks . ^^^ The results showed that ( 1 ) there was a slight expression of jun mRNA but not fos and myb mRNA in the control normoxic rats ' lung ; ( 2 ) it was found that a less expression of jun mRNA in lung after 1 week hypoxia , but after 2 week hypoxia jun mRNA elevated again and significantly increased after 3 week hypoxia as compared with that in normoxia ; ( 3 ) the oncogene myb mRNA expression showed significant increase in 1 and 2 week hypoxia and returned to normal status in 3 week hypoxia ; ( 4 ) after 1 to 3 week hypoxia , a significant increased expression of fos mRNA was found as compared with that in normoxia . ^^^ It is suggested hypoxia may induce increased expression of proto oncogene jun myb and fos , which may be related to proliferation of pulmonary arterial smooth muscle cells and fibroblasts . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This demonstration of nuclear immunoreactivity for Fos suggests that cellular glucopenia elicits the transcriptional activation , via AP 1 regulatory sites , of multiple populations of hypothalamic neurons characterized by the functional capacity to generate NO , and thus that this gaseous neurotransmitter may fulfill a role ( s ) in central neural mechanisms governing regulation of compensatory motor responses to metabolic imbalance . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cell death process is accompanied by induction of JunB , c Jun , JunD and Fos proteins . ^^^ In addition , dose response and time course studies provided strong correlative evidence that Fos and Jun proteins are involved in the apoptotic death cascades . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nuclear translocation of Fos is stimulated by interaction with Jun through the leucine zipper . ^^^ Jun and Fos , b ZIP transcription factors , form a heterodimer and bind to DNA enhancer elements , thereby regulating the expression of target genes . ^^^ The present study was undertaken to investigate the molecular mechanism underlying nuclear translocation of the Jun / Fos complex . ^^^ For this purpose , normal rat kidney cells were microinjected with a DNA expression vector containing wild type or mutant c or 5 jun together with c or 5 fos , followed by detection of the subcellular localization of Jun or Fos by immunofluorescence staining . ^^^ The nuclear accumulation of Fos was markedly enhanced by the presence of wildtype Jun , but not by Jun mutants lacking nuclear targeting or zipper dimerization functions , implying that Jun and Fos mutually interact via their leucine zippers and translocate from the cytoplasm to the nucleus using the markedly stronger nuclear localization signal of Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This change in the fos / jun ratio has important implications for the composition of the AP 1 transcription factor and for the expression of genes that it regulates . . ^^^ Fluorescence in situ hybridization analysis of the fos / jun ratio in the ageing brain . ^^^ We have examined the expression of the fos and jun genes in the cerebellum of the rat brain during ageing , by use of a semi quantitative fluorescence in situ hybridization ( FISH ) method . ^^^ In these experiments we have utilised the digital imaging capabilities of a cooled CCD camera system to store the fluorescence intensities of individual cells and to compare the data from each target ( fos or jun ) gene with that of a control ( beta actin ) gene . ^^^ In this way we have been able to obtain a relative quantitation of fos and jun mRNA levels . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analyses demonstrated that the AP 1 complex induced by TGF beta 1 was composed of Jun isoforms and absent of Fos isoforms . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Nestler , Induction of a long lasting AP 1 complex composed of altered Fos like proteins in brain by chronic cocaine and other chronic treatments , Neuron 13 ( 1994 ) 1235 1244 [ 10 ] ; T . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The increased activity of transcription factor AP 1 , a complex of oncoproteins Jun and Fos , is associated with cell growth and proliferation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine why alveolar macrophages do not express AP 1 DNA binding activity , we first showed that there was not a decrease in expression of the FOS and JUN proteins that make up the AP 1 complex . ^^^ There was , however , a significant difference in the amounts of the nuclear protein , REF 1 ( which regulates AP 1 DNA binding by altering the redox status of FOS and JUN proteins ) , in alveolar macrophages compared with monocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , to gain further insight into how AP 1 family members regulate expression of the loricrin gene , we co transfected the loricrin reporter constructs with expression plasmids for various fos and jun family members and demonstrated that c Fos / Jun B heterodimers could mimic the differentiation specific induction of loricrin . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously shown that they interact with the adenovirus E1a oncoprotein , mediating part of its transcriptional activity and heterodimerize with the Jun , Fos or related transcription factors , thereby modulating their DNA binding specificity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NFAT 5 , a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun . ^^^ NFAT transcription factors are related to NF kappaB / Rel proteins and form cooperative complexes with Fos and Jun on DNA . ^^^ However , it lacks the majority of Fos / Jun contact residues and does not bind cooperatively with Fos and Jun to DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factor , which is composed of various combinations of Fos and Jun proteins , is believed to be a key participant in molecular processes that guide activity dependent changes in gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , helical phasing analysis indicates that GKH Fos ( 139 211 ) / Jun ( 248 334 ) and control Fos ( 139 211 ) / Jun ( 248 334 ) both bend the DNA at the AP 1 site toward the minor groove . ^^^ Our results suggest that the unfavorable energetic cost of the increased DNA bending by GKH Fos ( 139 211 ) / Jun ( 248 334 ) results in a decrease in both specificity and affinity of binding of the heterodimer to the AP 1 site . ^^^ GKH Fos ( 139 211 ) / Jun ( 248 334 ) ( GKH : glycine lysine histidine ) is a modified Fos / Jun heterodimer designed to contain a metal binding motif in the form of a GKH tripeptide at the amino terminus of Fos bZIP domain dimerized with the Jun basic region leucine zipper ( bZIP ) domain . ^^^ We examined the effect of the addition of positively charged GKH motif to the N terminus of Fos ( 139 211 ) on the DNA binding characteristics of the Fos ( 139 211 ) / Jun ( 248 334 ) heterodimer . ^^^ However , due to the presence of the positively charged GKH motif on Fos , the degree of the induced bend by GKH Fos ( 139 211 ) / Jun ( 248 334 ) is greater than that induced by the unmodified Fos / Jun heterodimer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factor ( the Jun and Fos proteins ) is suspected of playing an important role in the biology of human cancer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
As extracellular signal regulated kinase ( Erk ) and stress activated protein kinase / c Jun N terminal kinase ( SAPK / JNK ) phosphorylation may induce Fos and Jun gene transcription and activator protein 1 ( AP 1 ) DNA binding , the activation of Erk 1 , Erk 2 , p 38 , and SAPK / JNK was examined in the nucleus tractus solitarii and neocortex during hypoxia and following administration of MK 801 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Addition of Fos and Jun dimerization domains to the N termini of hCGalpha and hCG / hFSHbeta subunit chimeras overcame the effects of the seatbelt mutations on subunit combination and enabled preparation of heterodimers containing six , seven , or nine residues in their seatbelt loops . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In conclusion , we show that Fos and GnRH activity does not correlate in the frog brain and , for the first time in a vertebrate species , we give evidence of a cytoplasmic AP 1 complex in neuronal cells . . ^^^ The complex was not available in the nuclear extracts from the same preparation , suggesting that , besides Fos , Jun products were also present . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Increased nuclear binding of AP 1 and NF kappaB after injury was associated with increased expression of fos , jun , and p 105 subunit mRNA and restored the proliferative response of SMC after balloon injury . ^^^ Phosphorylation of transcription factors fos / jun dimer activator protein ( AP ) 1 and nuclear factor kappaB ( NF kappaB ) plays a cardinal role in vascular smooth muscle cell ( SMC ) response to growth stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
During NGF mediated differentiation , an increase in the expression of specific mRNAs for the early response genes Fos , cJun , and NGF1a was detected in both the vector control and Rsu 1 transfectants . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
It has recently been reported that the glucocorticoid receptor inhibits activity of the AP 1 transcription factor by the ligand dependant binding of glucocorticoid receptor ( GR ) to the fos and jun components of AP 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift analysis using antibodies against different Jun and Fos family members differentiated between AP 1 DNA binding in hippocampal nuclear extracts obtained 2 and 18 h after the administration of KA . ^^^ These results suggest that neuronal death may not always follow modulation of de novo synthesis of particular proteins through sustained potentiation of AP 1 DNA binding which involves expression of different Jun and Fos family members in response to systemic administration of KA in murine hippocampus . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
SHORT COMMUNICATION maternal thyroid dysfunction and c fos and c jun expression in rat placenta . ^^^ To investigate whether these effects occur secondary to placental dysfunction , c fos and c jun expression in placenta from normal ( euthyroid ) and moderately hypothyroid rat dams were investigated by Northern hybridization analysis . ^^^ In normal placenta , c fos expression increased by 74 per cent between 16 and 21 days of gestation ( dg ) whereas c jun expression declined by 46 per cent . ^^^ Moderate maternal hypothyroidism depressed placental c fos expression by 32 per cent at 19 dg , but elevated c fos and c jun expression by 139 and 86 per cent , respectively , at 21 dg . ^^^ Maternal hypothyroidism may therefore induce c fos / c jun related placental dysfunction , but only relatively late in gestation when fetal thyroid function is already established . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The current studies investigated the role of this neurotransmitter in glucoprivic induction of AP 1 transcriptional activity in hypothalamic vasopressinergic neurons by examining whether pharmacological manipulation of central nitric oxide / guanylate cyclase / cGMP signaling alters nuclear accumulation of Fos immunoreactivity in these cells . ^^^ The present studies demonstrate that exogenous activation of the nitric oxide / guanylate cyclase / cGMP pathway in the brain inhibits nuclear accumulation of the AP 1 transcription factor , Fos , in vasopressinergic neurons during cellular glucopenia , and suggest that this neurotransmitter is critical for transactivational effects of glucoprivation on these neuropeptidergic neurons . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Substantial chemical data have also been presented which implicate Cys SOH in redox regulation of transcription factors such as Fos and Jun ( activator protein 1 ) and bovine papillomavirus 1 E 2 protein . ^^^ In Fos and Jun and the E 2 protein , on the other hand , a key Cys SH serves as a sensor for intracellular redox status ; reversible oxidation to Cys SOH as proposed inhibits the corresponding DNA binding activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These results suggest a common selective process in the genesis of these three viral oncoproteins and a mechanistic link with Jun , Fos and Myb oncoproteins which are also stabilized relative to their cellular counterparts . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Maf is a basic domain / leucine zipper domain protein originally identified as a proto oncogene whose consensus target site in vitro , the T MARE , is an extended version of an AP 1 site normally recognized by Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Tissue activation of liver and kidney was assessed by staining of immediate early gene products ( IEG : FOS , JUN ) , and inflammatory markers ; cell adhesion molecules ( Intercellular adhesion molecule 1 , vascular cell adhesion molecule 1 ) , leukocyte infiltrates ( CD 45 , T cell receptor , CD 8 , CD 4 ) , and MHC class 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Meq dimerizes with Jun or Fos and the Meq / Jun heterodimer is able to transactivate promoters with AP 1 site . ^^^ We have previously described Meq protein ( MEQ gene product ) , a transcriptional factor with homology to proto oncogenes Jun and Fos in the bZIP domain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , to gain insight into the functional composition of the AP 1 complex , supershift analysis was performed to characterize which Fos and Jun family members are included in the AP 1 binding complex at the different time points analyzed . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The primary components present in this TGFbeta stimulated AP 1 complex are JunD and Fra 2 , although c Jun , and possibly Fos B , may also be present . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
On the contrary , early immediate genes expressions ( c myc , NGF1B , egr 1 , genes of the fos and jun families ) were decreased . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Di n butyltin dichloride induced mRNA species included members of the fos and jun proto oncogene families , c myc , egr 1 , ribonucleotide reductase ( R 2 subunit ) , odc , macrophage chemotactic protein / je , hsp 70 , metallothionine IIA , c sod and mn sod . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Immediate early genes , including fos , jun , and early growth response 1 ( Egr 1 ) , are induced during cellular response to changes in extracellular environment . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of calpain with ALLN causes preadipocytes to arrest just prior to S phase and prevents phosphorylation of the retinoblastoma gene product , DNA replication , clonal expansion , and subsequent adipocyte differentiation but does not affect the expression of immediate early genes ( i . e . fos , jun , C / EBPbeta , and C / EBPdelta ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After 3 h there were increased levels of AP 1 and CREB , with increased amounts of Fos family , Jun B and Jun D transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatments that caused dyskinesias induced , in the striatum , chronic Fos proteins of the deltaFosB family which , when coupled with Jun D , form AP 1 complexes that can affect several genes , including enkephalin and N methyl D aspartate receptor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
B ATF functions as a negative regulator of AP 1 mediated transcription and blocks cellular transformation by Ras and Fos . ^^^ Jun / B ATF dimers display similar DNA binding profiles as Jun / Fos dimers , with a bias toward binding TRE ( 12 O tetradecanolyphorbol 13 acetate response element ) over CRE ( cyclic AMP response element ) DNA sites . ^^^ B ATF inhibits transcriptional activation of a reporter gene containing TRE sites in a dose dependent manner , presumably by competing with Fos for Jun and forming transcriptionally inert Jun / B ATF heterodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ATFa proteins , which are members of the CREB / ATF family of transcription factors , have previously been shown to interact with the adenovirus E1a oncoprotein and to mediate its transcriptional activity ; they heterodimerize with Jun , Fos or related transcription factors , possibly altering their DNA binding specificity ; they also stably bind JNK 2 , a stress induced protein kinase . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
IL 4 deprivation induces downregulation of Jun expression and upregulation of Fos expression , both of which are proteins involved in the formation of AP 1 and AP 1 like transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
While gene expression studies have focused on MYC , effects of ELF EMFs on the expression of beta actin , histone H2B , beta tubulin , SRC , FOS and JUN have also been reported . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factor AP 1 , composed of Jun and Fos proteins , is a major target of mitogen activated signal transduction pathways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In cooperation with constitutively expressed Jun , Fos presumably serves as a transcription factor altering gene expression during cell growth and differentiation processes in the gland associated with adaptation to osmotic stress in animals . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A model is proposed where the actions of IGF 1 and NGF contribute to the combinatorial expression of Jun and Fos family members in particular domains of the otic vesicle . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , Ski repressed a TGF beta inducible promoter containing AP 1 ( TRE ) elements activated by a combination of Smads , Fos , and / or Jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Many transcription factors , including Nrf , Jun , Fos , Fra , Maf , YABP , ARE BP 1 , Ah ( aromatic hydrocarbon ) receptor , and estrogen receptor bind to the ARE from the various genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A detailed analysis of the repression by p21SNFT repression on the IL 2 promoter distal NF AT / AP 1 site demonstrates that it can bind DNA with NF AT and Jun , strongly suggesting that it represses NF AT / AP 1 activity by competing with Fos proteins for Jun dimerization . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 complexes bound to the AP 1 sequence contained c Jun , and those bound to the NF AT AP 1 composite site contained c Jun and Fos . ^^^ AP 1 complexes bound to the AP 1 sequence contained c Jun , and those bound to the NF AT AP 1 composite site contained c Jun and Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The TPA induced complex was supershifted in the presence of antibody against the Jun family of proteins , but not the Fos family of proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The calcium signal activates the calmodulin ( CaM ) dependent phosphatase calcineurin , which dephosphorylates the regulatory domain of NFAT and promotes its nuclear import , while the phorbol ester signal results in synthesis and activation of Fos and Jun , transcription factors that bind cooperatively with the NFAT DNA binding domain in the nucleus to mediate the transcription of many target genes . ^^^ Our data indicate that a 144 amino acid segment of NFAT 1 , containing the N terminal TAD but lacking the DNA binding and Fos / Jun interaction domains , resembles the full length protein in requiring a combined input from two separate signaling pathways for optimal function in cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reconstruction experiments with the fos and jun leucine zippers detected protein protein interactions between either homodimeric or heterodimeric leucine zippers . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results show that hydroxyl radicals generated by the Fenton reaction induced apoptosis in cerebellar granule cells , which was associated with the decrease in the Bcl 2 mRNA level and the increase in the protein levels of the transcription factors Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , all GABA ( B ) receptor antagonists were able to induce an increase in Fos and Jun protein expression in pentylenetetrazole ( 25 mg / kg i . p . ) treated mice whilst the GABA ( B ) receptor agonist R baclofen ( 2 or 6 mg / kg ) attenuated the expression of Fos and Jun protein , at cortical and limbic structures . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ATF 3 is a transcription factor belonging to the Jun / Fos family whose mouse homologue ( TI 241 ) was isolated , using the differential screening method , from B 16 mouse melanoma cells as a blood borne metastasis associated gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Inhibition of growth of OV 1063 human epithelial ovarian cancers and c jun and c fos oncogene expression by bombesin antagonists . ^^^ In OV 1063 cells cultured in vitro , GRP ( 14 27 ) induced the expression of mRNA for c jun and c fos oncogenes in a time dependent manner . ^^^ Antagonist RC 3940 2 inhibited the stimulatory effect of GRP ( 14 27 ) on c jun and c fos in vitro . ^^^ In vivo , the levels of c jun and c fos mRNA in OV 1063 tumours were decreased by 43 % ( P < 0 . 05 ) and 45 % ( P = 0 . 05 ) respectively , after treatment with RC 3940 2 at 20 microg per day . ^^^ Our results indicate that antagonists of bombesin / GRP inhibit the growth of OV 1063 ovarian cancers by mechanisms that probably involve the downregulation of c jun and c fos proto oncogenes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Cooperation between nuclear factor of activated T cells ( NFAT ) and AP 1 ( Fos Jun ) proteins on composite NFAT AP 1 DNA elements constitutes a powerful mechanism for signal integration of the calcium and protein kinase C / Ras pathways in the regulation of gene expression . ^^^ Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun . ^^^ Here we report that NFAT can induce expression of certain genes in T cells without the need for cooperative recruitment of Fos and Jun . ^^^ Using NFAT 1 mutant proteins that are unable to interact with Fos Jun dimers but are unaffected in DNA binding or transcriptional activity , we show that expression of interleukin ( IL ) 2 , granulocyte macrophage colony stimulating factor ( GM CSF ) , IL 3 , IL 4 , MIP1alpha and Fas ligand mRNAs is absolutely dependent on cooperation between NFAT and Fos Jun ; in contrast , NFAT induces tumor necrosis factor alpha ( TNFalpha ) mRNA and IL 13 promoter activity without any necessity to recruit Fos and Jun . ^^^ Furthermore , we show that NFAT Fos Jun cooperation is also essential to elicit the NFAT dependent program of activation induced cell death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This review deals with the induction of Fos , Jun and Egr ( Krox ) transcription factors in response to NMDA or non NMDA ( AMPA / kainate ) ionotropic receptor agonists in vivo or in neuronal cultures in vitro . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 DNA binding complex is not a single transcription factor but a dimer consisting of members of Fos and Jun families . ^^^ AP 1 DNA binding complex is not a single transcription factor but a dimer consisting of members of Fos and Jun families . ^^^ Furthermore , we describe biochemical properties of Fos and Jun proteins that may explain the ability of this transcription factor to activate different sets of genes in response to different stimuli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ape1 / ref 1 has been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression such as Fos , Jun , NF ( B , PAX , HIF 1 ( , HLF and p 53 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , two other bZip oncoproteins , Fos and Jun , failed to associate with the Hox proteins , while a distantly related Hox family member , Meis 1 , could not interact with Maf . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos / Jun dimers . ^^^ Fos family proteins form stable heterodimers with Jun family proteins , and each heterodimer shows distinctive transactivating potential for regulating cellular growth , differentiation , and development via AP 1 binding sites . ^^^ SNF chromatin remodeling complex , is a determinant of the transactivation potential of Fos / Jun dimers . ^^^ BAF60a binds to a specific subset of Fos / Jun heterodimers using two different interfaces for c Fos and c Jun , respectively . ^^^ SNF complex is present , can c Fos / c Jun ( high affinity to BAF60a ) but not Fra 2 / JunD ( no affinity to BAF60a ) induce the endogenous AP 1 regulated genes such as collagenase and c met . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
They are also involved in DNA binding and transactivation processes resembling the situation in AP 1 ( Jun / Fos ) dependent DNA binding in rheumatoid synovium . ^^^ Coiled coil domains can also be found in jun and fos oncogene products , which are frequently upregulated in RA synovial fibroblasts . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The level of estrogen ( ER ) and progesterone receptor ( PR ) proteins , the hormone binding of E ( 2 ) receptors and the effects of single injection of ENK with or without naltrexone ( NAL ) on the E ( 2 ) induced changes in the level of Fos and Jun proteins and the binding of AP 1 proteins to DNA were studied . ^^^ The E ( 2 ) induced increase in the level of Fos proteins and the binding of AP 1 proteins to DNA was inhibited by a single injection of ENK . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We demonstrate that AP 1 ( Fos and Jun ) , induced transiently by CD 40 ligand or LPS , binds a DNA element in the mouse GL epsilon promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of the investigated proto oncogenes ( Fos , Jun , ErbB 1 , ErbB 2 , Myc , Ras ) , only ErbB 2 is weakly associated with the in vitro short term test . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The bZIP proteins Fos and Jun bind DNA rapidly and with high affinity , forming a heteromeric complex that mediates activated transcription . ^^^ Though dimerization of Fos and Jun occurs rapidly in the absence of DNA , the rate of dimerization is enhanced in the presence of DNA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Long range electrostatic interactions influence the orientation of Fos Jun binding at AP 1 sites . ^^^ Fos Jun heterodimers bind to AP 1 sites with different flanking sequences in opposite orientations . ^^^ A gel based fluorescence resonance energy transfer assay , gelFRET , was used to define the mechanism whereby amino acid residues and nucleotide base pairs outside the Fos Jun AP 1 contact interface determine the orientation of heterodimer binding . ^^^ Single amino acid and base pair substitutions had parallel effects on DNA bending by Fos Jun AP 1 complexes and on heterodimer orientation . ^^^ The binding orientation exhibited a close correspondence with both the difference in bending propensities of opposite sides of the AP 1 site as well as the difference in bending potentials of the Fos and Jun subunits of the heterodimer . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Extracellular ionotropic glutamate ( Glu ) signals lead to rapid and selective potentiation of DNA binding of the nuclear transcription factor activator protein 1 ( AP 1 ) that is a homo and heterodimeric complex between Jun and Fos family members , in addition to inducing expression of the corresponding proteins , in a manner unique to each Glu signal in murine hippocampus . ^^^ Therefore , extracellular Glu signals may be differentially transduced into the nucleus to express AP 1 with different assemblies between Jun and Fos family members , and thereby to modulate de novo synthesis of the individual target proteins at the level of gene transcription in the hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We now demonstrate that : ( 1 ) NO targets two transcriptional elements in the fos promoter , i . e . , the fos AP 1 binding site and the cAMP response element ( CRE ) ; ( 2 ) NO activation of these two enhancer elements requires the CRE binding protein CREB because a dominant negative CREB fully inhibits NO transactivation of reporter genes whereas dominant negative Fos or CCAAT enhancer binding proteins have no effect ; ( 3 ) CREB is phosphorylated by G kinase in vitro and its phosphorylation increases in vivo when G kinase is activated either directly by cGMP or indirectly by NO via soluble guanylate cyclase ; ( 4 ) NO activation of fos promoter elements requires nuclear translocation of G kinase but not activation of mitogen activated protein kinases . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) , a dimeric complex consisting of proteins encoded by the jun and fos gene families , is a transcription factor induced by a variety of signals including those eliciting proliferation , differentiation , and neoplastic transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
One of the two complexes was shown to contain a member of the fos family of transcription factors but no jun family members were involved . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Oxidative stress in the conceptus is characterized by an increased oxidized to reduced glutathione ( GSSG : GSH ) ratio and the induction of fos and jun mRNAs , transcripts for components of the activator protein 1 ( AP 1 ) transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ROS are known to regulate the activity of transcription factors such as activator protein 1 ( AP 1 ) , which is a dimer consisting of members of the Jun and Fos families . ^^^ Protein expression of c Jun and c Fos was examined by immunohistochemistry and Western blotting . ^^^ RESULTS : In wild type mice , immunohistochemistry demonstrated acute c Jun and c Fos activation in ischemic cortex and its outer boundary . ^^^ Western blotting confirmed that SOD 1 overexpression was associated with reduced c Jun and c Fos protein levels in ischemic brain . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , A 2 could rapidly increase mRNA levels of several factors belonging to the Fos and Jun families which may be components of the AP 1 complex . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Jun , Fos and Krox in the hippocampus after noxious stimulation : simultaneous input dependent expression and nuclear speckling . ^^^ Stimulation of sensory C fibres produces extensive expression of the Fos , Jun and Krox families of inducible transcription factors ( ITFs ) in many nociceptive CNS areas [ 28 ] . ^^^ MK 801 blocked these changes in ITF expressions , but it could also cause the C fibre stimulations to induce c Fos and c Jun in specific areas of the hippocampus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Control of the orientation of Fos Jun binding and the transcriptional cooperativity of Fos Jun NFAT 1 complexes . ^^^ Fos Jun heterodimers bind in opposite orientations to AP 1 sites with different flanking sequences . ^^^ Base pairs at positions + / 6 and + / 10 relative to the center of the AP 1 site were the principal determinants of Fos Jun binding orientation . ^^^ Amino acid residues of opposite charge adjacent to the basic regions of Fos and Jun had independent effects on heterodimer orientation . ^^^ Exchange of these amino acid residues between the basic region leucine zipper domains of Fos and Jun reversed the binding orientation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Effect of immobilization and concurrent exposure to a pulse modulated microwave field on core body temperature , plasma ACTH and corticosteroid , and brain ornithine decarboxylase , Fos and Jun mRNA . ^^^ Core body temperatures , plasma levels of the stress induced hormones adrenocorticotrophic hormone ( ACTH ) and corticosterone , and brain levels of ornithine decarboxylase ( Odc ) , Fos and Jun mRNAs were measured as potential markers of stress responses mediated by RF radiation . ^^^ Levels of Odc , Fos and Jun mRNA were also monitored in brains of animals exposed to the RF field for 2 h , and they showed no differences from sham exposed ( loose tube immobilized ) animals that were due to RF field exposure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This review describes the different DNA binding domains of the MMP 9 gene , summarizes our knowledge about the transcription factors involved and speculates about a potential role of these transcription factors ( particularly the oncogenes Jun and Fos ) in regulating trophoblast invasion . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg Jun / Fos DNA ternary complex formation . ^^^ Jun , Fos , and Ets proteins belong to distinct families of transcription factors that target specific DNA elements often found jointly in gene promoters . ^^^ Here we used the known three dimensional structures of the ETS DNA binding domain and Jun / Fos heterodimer to model an ETS Jun / Fos DNA ternary complex . ^^^ To support the model , different Erg ETS domain mutants were obtained by deletion or by single amino acid substitutions and were tested for their ability to mediate DNA binding , Erg Jun / Fos complex formation , and transcriptional activation . ^^^ We identified point mutations that affect both the DNA binding properties of Erg and its physical interaction with Jun ( R367K ) , as well as mutations that essentially prevent transcriptional synergy with the Jun / Fos heterodimer ( Y371V ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activity of extracellular regulated kinases ( ERK ) 1 and 2 and c jun and c fos mRNA levels were significantly elevated in CAPAN 2 cells cultured continuously in serum free medium . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
All of these adaptive responses coexist within a signaling scheme that could account for known inductions of genes ( e . g . fos and jun proteins , and cyclic AMP response element binding protein ) previously shown to be relevant to cocaine ' s behavioral actions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A crucial step in the BER pathway involves the cleavage of baseless sites in DNA by an apurinic / apyrimidinic or baseless ( AP ) endonuclease ( Ape1 / ref 1 ) , which is a multifunctional enzyme that acts not only as an AP endonuclease but also as a redox modifying factor for a variety of transcription factors including Fos , Jun , paired box containing genes ( PAX ) , nuclear factor kappaB , hypoxia inducible factor alpha ( HIF 1alpha ) , HIF like factor ( HLF ) , p 53 , and others . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Drosophila puckered regulates Fos / Jun levels during follicle cell morphogenesis . puckered ( puc ) encodes a VH 1 like phosphatase that down regulates Jun kinase ( JNK ) activity during dorsal closure of the Drosophila embryo . ^^^ Strikingly , decreased or increased puc function leads to a corresponding increase or decrease , respectively , of Fos and Jun protein levels . ^^^ Consistent with this , overexpression of a dominant negative DRac 1 resulted in lower levels of Fos / Jun . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Even though the basal level AP 1 protein DNA binding pattern is different between normal and malignant cells , PMA significantly enhances Jun and Fos binding to the consensus TRE site in both cell types . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we use direct binding assays , native gel electrophoresis , and fluorescence polarization measurements to show for the first time that the cAMP response element binding protein ( CREB ) and related AP 1 and jun and fos constituents are recognized by importin beta 1 ( Impbeta ) with nanomolar affinity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We showed here that there were dramatic changes in protein components of AP 1 including an initial recruitment of the transcriptional activators c Fos and Jun B then of Fra 2 and Jun D . ^^^ Moreover , the presence of Fra 2 / Jun D dimers suppressed the CRH induction of c fos mRNA expression as well as c Fos / Jun B recruitment in AP 1 complexes , suggesting the existence of autoregulatory loops of AP 1 composition that involve complex interactions between the different members of the Jun and Fos families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In this study , we used expression vectors for wild type , dominant negative , and forced homodimeric ( Jun / eb1 chimeric factors ) forms of JunD and other Fos and Jun proteins to determine the requirement for JunD in the transcriptional regulation of the TIMP 1 and interleukin 6 ( IL 6 ) genes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Antibody supershift electrophoretic mobility shift assays did not detect Jun , Fos , or ATF / CREB proteins but identified Nrf 2 and the small Maf protein , MafG , as components of complex 10 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
More than a decade ago our view of gene regulation by glucocorticoids ( GC ) and other steroid hormones underwent a dramatic change with the discovery of negative crosstalk ( transcriptional interference ) between the GC receptor ( GCR ) and transcription factor AP 1 ( Jun : Fos ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 family consists of several bZIP ( basic region leucine zipper ) domain proteins , the Jun , the Fos , and the ATF subfamilies , which all have to dimerize before they can bind to their DNA target sites . ^^^ Although we have come a long way from discovering its major components , the heterodimer between c Fos and c Jun , it is daunting to realize that we still lack a detailed molecular knowledge of how these factors interact with DNA to activate or repress genes in the nucleus . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In recent years , studies in the model organism Drosophila melanogaster have contributed significant insights into the molecular and developmental biology of the AP 1 transcription factors Jun and Fos . ^^^ The range of biological processes that Jun and Fos regulate in this organism is equally multi faceted . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factor is composed of a mixture of homo and hetero dimers formed between Jun and Fos proteins . ^^^ The different Jun and Fos family members vary significantly in their relative abundance and their interactions with additional proteins generating a complex network of transcriptional regulators . ^^^ Thus , the functional activity of AP 1 in any given cell depends on the relative amount of specific Jun / Fos proteins which are expressed , as well as other potential interacting proteins . ^^^ We shall discuss recent studies which suggest that different Jun and Fos family members may have both opposite and overlapping functions in cellular proliferation and cell fate . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Extensive analyses of mice and cells with genetically modified Fos or Jun proteins provide novel insights into the physiological functions of AP 1 proteins . ^^^ Using knock out strategies it was found that some components , such as c Fos , FosB and JunD are dispensable , whereas others , like c Jun , JunB and Fra 1 are essential in embryonic development and / or in the adult organism . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Close encounters of many kinds : Fos Jun interactions that mediate transcription regulatory specificity . ^^^ Fos and Jun family proteins regulate the expression of a myriad of genes in a variety of tissues and cell types . ^^^ Several general principles including binding cooperativity and conformational adaptability have emerged from studies of regulatory complexes containing Fos Jun family proteins . ^^^ The structural properties of Fos Jun family proteins including opposite orientations of heterodimer binding and the ability to bend DNA can contribute to the assembly and functions of such complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis . ^^^ Jun : Fos and Jun : ATF complexes represent two classes of AP 1 dimers that ( 1 ) preferentially bind to either heptameric or octameric AP 1 binding sites , and ( 2 ) are differently regulated by cellular signaling pathways and oncogene products . ^^^ To discriminate between the functions of Jun : Fos , Jun : ATF and Jun : Jun , mutants were developed that restrict the ability of Jun to dimerize either to itself , or to Fos ( like ) or ATF ( like ) partners . ^^^ Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The four calcium regulated transcription factors of the NFAT family act synergistically with AP 1 ( Fos / Jun ) proteins on composite DNA elements which contain adjacent NFAT and AP 1 binding sites , where they form highly stable ternary complexes to regulate the expression of diverse inducible genes . ^^^ Concomitant induction of NFAT and AP 1 requires concerted activation of two different signaling pathways : calcium / calcineurin , which promotes NFAT dephosphorylation , nuclear translocation and activation ; and protein kinase C ( PKC ) / Ras , which promotes the synthesis , phosphorylation and activation of members of the Fos and Jun families of transcription factors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have identified seven ERK related proteins ( `` ERPs ' ' ) , including ERK 2 , that are stably associated in vivo with AP 1 dimers composed of diverse Jun and Fos family proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interestingly , APE also possesses an activity ( Ref 1 ) that controls the redox status of a number of transcription factors including Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
By supershift experiments , jun and fos proteins were identified as components of the CA activated AP 1 complexes . ^^^ Western blot analyses revealed that the induction of the AP 1 activity was not dependent to an increase in the levels of jun and fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The extracellular signals are transduced by the activation of classical signal transduction pathways , such as those involving PKA and PKC , and pivotal transcription regulators , i . e . the Fos , Jun and SMAD proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assay , transcription of the target genes , and Western analysis studies indicated that the increased AP 1 binding activity was attributable to induction of the Jun but not the Fos protein families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of Jun D , but not of the other Jun or Fos proteins increased by threefold NF kappaB transactivation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These data argue for a combined regulation of cpcA that includes a translational regulation like that of yeast GCN 4 as well as a transcriptional regulation like that of the mammalian jun and fos genes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interestingly , Ape1 / ref 1 is a multifunctional protein that not only is a DNA repair enzyme , but also functions as a redox factor maintaining transcription factors , such as Fos , Jun , nuclear factor kappaB , PAX ( paired box containing family of genes ) , hypoxia inducible factor lalpha ( HIF 1alpha ) , HIF 1 like factor , and p 53 , in an active reduced state . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although fos and jun proteins were still clearly present at 60 cPD , utilisation of the AP 1 DNA consensus sequence could not be demonstrated after 54 cPD . ^^^ After 49 cPD there was a gradual decline in the levels of fos and jun proteins , but disproportionately , so that the fos / jun protein ratio also declined . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to identify central cell populations that are functionally responsive to decreased SGLT 1 function in the brain , the present study utilized immunocytochemical techniques to demonstrate cellular expression of the inducible activator protein 1 transcription factor , Fos , following i . c . v . delivery of phlorizin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 activation and altered AP 1 composition in association with increased phosphorylation and expression of specific Jun and Fos family proteins induced by vinblastine in KB 3 cells . ^^^ AP 1 activation and altered AP 1 composition in association with increased phosphorylation and expression of specific Jun and Fos family proteins induced by vinblastine in KB 3 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 , composed of fos and jun proteins , is a critical effector of TCR signaling and binds several sites in the IL 2 promoter . ^^^ AP 1 , composed of fos and jun proteins , is a critical effector of TCR signaling and binds several sites in the IL 2 promoter . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Stimulation of APP promoter activity by BDNF was not affected by the PKC inhibitor bisindolylmaleimide , or by dominant negative mutants of the AP 1 components Fos and Jun , which , however , blocked the response to phorbol esters . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Supershift assays using antibodies directed against different members of the Fos and Jun protein families showed that the AP 1 complex in retinal neurons includes proteins of the Fos family , namely , Fra 2 , c Jun , and Jun D . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Among these we identified two oncogene products ( Jun and Fos ) which were activated by TNF or phorbol esters and which promoted the synthesis of MMP 9 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
RESULTS : In contrast to non endocrine tumours of the digestive system such as carcinoma of the pancreas , colon and stomach , dNETs do not show alterations in oncogenes ( ras , Myc , fos jun , Src ) or in common tumor suppressor genes [ p 53 , retinoblastoma suspectibility gene ( Rb ) ] . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Actin , TNF alpha , Fos , Jun protein and their mRNA expression levels in small airway epithelium were analyzed by immunohistochemistry and in situ hybridization . ^^^ Fos and Jun proteins may also play important roles in up regulating the TNF alpha protein . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
However , we identified another Fos family member , Fra 1 , together with its transcriptional activation partner , c Jun , as being stably up regulated in GBM cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Of the proto oncogenes and suppressor gene products N RAS , P 53 , FOS and JUN revealed a relationship to the take rate of NSCLC , while such a relationship was not found with MYC , ERBB 1 and ERBB 2 . ^^^ The expression of JUN , N RAS , FOS , cyclin D , and cdk 4 were significantly different in both groups with non overlapping confidence intervals . ^^^ Thus , the up regulation of the proteins JUN , N RAS , FOS , cyclin D and cdk 4 predicts the growth of NSCLC in nude mice . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The activator protein 1 ( AP 1 ) transcriptional complex , containing Jun and Fos proteins , is involved in regulating many cellular processes such as proliferation and differentiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^ All cells expressed fos , fra 1 and jun proteins and none expressed fosB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The apoptotic elimination of the proliferative cells was accompanied by rapid upregulation of c jun , downregulation of c fos , and activation of the AP 1 complex , which normally only occur during the differentiation process of post mitotic keratinocytes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Ribonuclease protection assays demonstrated that increases in mRNA levels of the early response protooncogenes c jun , junB , fra 1 , and fra 2 accompanied cell proliferation at low concentrations of PM whereas apoptotic concentrations of PM caused transient increases in expression of fos and jun family members and dose responsive increases in mRNA levels of receptor interacting protein , Fas associated death domain , and caspase 8 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Adenoviral delivery of A FOS , an AP 1 dominant negative , selectively inhibits drug resistance in two human cancer cell lines . ^^^ To assess the clinical efficacy of AP 1 inhibition toward reversing drug resistance , we have developed an adenovirus expressing a dominant negative that inhibits AP 1 DNA binding , namedAdA FOS . ^^^ Because of an association of up regulated AP 1 activity with their drug resistance , these cell lines were considered good targets of AdA FOS therapy . ^^^ Although the efficiency of AdA FOS in therapy would need to be further analyzed with other cisplatin resistant and mdr cell lines , these results suggest that AP 1 is a therapeutic molecular target and that inhibition of AP 1 DNA binding may be of clinical value in treating chemotherapeutic resistance . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
For elucidation of mechanisms underlying long term consolidation of transient extracellular signals , we have examined expression and degradation of particular Fos family member proteins required for assembly to the nuclear transcription factor activator protein 1 in this study . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 transrepressing retinoic acid does not deplete coactivators or AP 1 monomers but may target specific Jun or Fos containing dimers . ^^^ Overexpression of AP 1 components did not rescue TPA induced AP 1 activation nor did a GST pull down experiment implicate direct binding , thus rendering unlikely both a Jun / Fos RA RAR direct interaction and a Jun / Fos sequestration mechanism . ^^^ RA treatment also did not block TPA induced ERK phosphorylation , Jun / Fos family protein expression except for cFos , or DNA binding of the AP 1 complex . ^^^ AP 1 transrepressing retinoic acid does not deplete coactivators or AP 1 monomers but may target specific Jun or Fos containing dimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , using a Drosophila model synapse , we analyse cellular functions and regulation of the best known immediate early transcription factor , AP 1 ; a heterodimer of the basic leucine zipper proteins Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To this end , the DM beta chain ectodomains were fused to acidic LZ domains ( AcidP 1 or Fos ) ; similarly , the DR 1 beta chain ectodomains were fused to basic LZ domains ( BaseP 1 or Jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Factors involved in proliferation ( ras , fos , erbB 1 , jun , cyclin A ) were downregulated whereas factors involved in apoptosis ( p 53 , bcl 2 , CD 95 ) were upregulated in the long survival group . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun proteins homo or heterodimerize to form functional AP 1 transcription factors . ^^^ Drosophila mutants lacking either Jun or Fos display indistinguishable dorsal open phenotypes , indicating an essential function of both Jun and Fos for embryonic dorsal closure . ^^^ By combining mutant alleles and transgenes expressing Fos and Jun variants with altered dimerization preferences , fly lines were generated in which only specifically defined dimer variants can form . ^^^ Phenotypic analysis of these mutants reveals that homodimers of Fos or of Jun can not replace the function of the heterodimeric complex . ^^^ This defect is not explained by the lower stability of homodimers as compared to heterodimers , because ' pseudo homodimers ' which are as stable as native Jun Fos heterodimers can not substitute for their function . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) is a group of dimeric transcription factors composed of Jun , Fos , and ATF family proteins . ^^^ Activator protein 1 ( AP 1 ) is a group of dimeric transcription factors composed of Jun , Fos , and ATF family proteins . ^^^ The resultant single chain AP 1 molecules showed DNA binding specificity and transcriptional activation potentials similar to those of untethered dimers , even in the presence of dominant negative AP 1 monomers . c Jun containing dimers showed distinct promoter specificity in transient transfection experiments , depending on the Fos , Fra , or ATF partner . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
FOS , P 53 , RAS , ERBB 1 , JUN , PCNA , cyclin A , FAS / CD95 , and HIF 1beta revealed a correlation to survival . ^^^ The expression of FOS , JUN , ERBB 1 , and cyclin A or PCNA were decreased in carcinomas of patients with long term survival . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Whereas IL 2 responsiveness requires Stat 5 and HMG 1 ( Y ) binding , TCR responsiveness of PRRIV requires two AP 1 and two NFAT binding sites that bind Jun , Fos and NFAT family members in vitro and in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
JunD , a member of the Jun family of nuclear transcription proteins , dimerizes with Fos family members or other Jun proteins ( c Jun or JunB ) to form the activator protein 1 ( AP 1 ) transcription factor . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To determine if D ( 2 ) dopamine receptor mediated nuclear signaling is altered during the development of amphetamine sensitization , we examined the expression of immediate early gene ( IEG ) products , Fos , Jun , and Fos related antigen ( FRA ) , in both controls and amphetamine sensitized rats after a challenge with the D ( 2 ) antagonist haloperidol . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Direct binding of AP 1 ( Fos / Jun ) proteins to a SMAD binding element facilitates both gonadotropin releasing hormone ( GnRH ) and activin mediated transcriptional activation of the mouse GnRH receptor gene . ^^^ Competition electrophoretic mobility shift assay experiments using 335 / 312 as probe and alphaT 3 1 nuclear extract or SMAD , Jun , and Fos proteins demonstrate direct binding of AP 1 ( Fos / Jun ) protein complexes to 327 / 322 and SMAD proteins to 329 / 328 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos is thought to be involved with long term changes in a neuron ' s structure and function that may underlie learning by altering the expression of other genes with AP 1 sites . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the MARE contains a consensus TRE sequence recognized by AP 1 , Jun and Fos family members may act to compete or interfere with the function of CNC small Maf heterodimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays ( EMSAs ) identified binding of the transcription factors CREB and Fos at the CRE in AtT 20 cells while CREB and cJun were detected in placental cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To test this possibility , we systematically compared the expression of the fos and Jun family immediate early genes in the nucleus accumbens and caudoputamen in D 1 receptor mutant and wild type control mice after acute and repeated cocaine exposure . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This report is the first demonstration that defined members of the Fos and Jun transcription factor families specifically regulate this gene under conditions relevant to critical pathophysiological processes . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This elevated phosphorylation of c Jun correlated with enhanced DNA binding and transcriptional activation of an AP 1 complex consisting of c Jun and Fos but lacking the c Jun antagonist JunB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using a ribonuclease protection assay , increased mRNA levels of fos and jun family members were seen in response to DQ 12 quartz and CMD with high quartz content . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
They include all members of the jun and fos families as well as the cAMP response element binding protein , activating transcription factor 1 , activating transcription factor 2 , and RelA ( p 65 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We tested the importance of the RA induced AP 1 activity by establishing clones which stably express a dominant negative fos gene ( A fos ) and have greatly diminished AP 1 activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This sustained transcriptional response correlated with a modest sustained increase in adrenal TH AP 1 binding , but not in the levels of Fra 2 or other fos or jun proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Asymmetric recognition of nonconsensus AP 1 sites by Fos Jun and Jun Jun influences transcriptional cooperativity with NFAT 1 . ^^^ Fos Jun heterodimers were found to bind nonconsensus AP 1 sites in a preferred orientation . ^^^ Jun dimerization with Fos versus ATF 2 caused it to bind opposite half sites at nonconsensus AP 1 elements . ^^^ The orientations of nonconsensus AP 1 sites within composite regulatory elements affected the cooperativity of Fos Jun as well as Jun Jun binding with NFAT 1 . ^^^ The asymmetric recognition of nonconsensus AP 1 sites can therefore influence the transcriptional activities of Fos and Jun both through effects on the orientation of heterodimer binding and through differential conformational changes in the two subunits of the dimer . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Interestingly , transient Erk activation resulted in altered AP 1 DNA binding activity and the induction of an AP 1 complex that was devoid of Fos protein and consisted of Jun Jun dimers . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Reciprocal effects of varicella zoster virus ( VZV ) and AP 1 : activation of jun , fos and ATF 2 after VZV infection and their importance for the regulation of viral genes . ^^^ Performing quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) we found an increase of transcription of AP 1 components jun , fos and of ATF 2 at different times post infection ( p . i . ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The expression of dominant negative Fos or C / EBP alpha proteins , which prevent binding of AP 1 or C / EBP complexes to DNA , also reduced CD 40 mediated IL 6 gene expression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
FHL 2 powerfully stimulates Fos and Jun dependent transcription , thereby acting as an inducible coactivator of AP 1 function . ^^^ Thus , FHL 2 , as an inducible coactivator of AP 1 , coordinately participates with Fos and Jun in the early transcriptional response to serum factors . . ^^^ Induction of FHL 2 is coordinated in time with the increased levels of two early response products , the oncoproteins Fos and Jun . ^^^ FHL 2 associates with both Jun and Fos , in vitro and in vivo . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Overexpression of Nrf 2 increased the tBHQ induced thioredoxin gene activation through the ARE , whereas that of Jun and Fos suppressed the activation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The results with the JDP 2 chimeras suggest that the JDP 2 homodimer and the JDP2 / Jun heterodimer ( or other bZip heterodimers formed with the Fos leucine zipper ) are nontransforming , leaving as possible transforming combination the JDP2 / Fos heterodimer . ^^^ The unexpected transforming activity of a negative regulator of TRE and CRE dependent transcription raises an important question concerning the mechanisms of transformation by the related bZIP proteins Jun and Fos that address the same target sequences . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Bimolecular complex formation between fragments of different fluorescent proteins did not differentially affect the dimerization efficiency of the bZIP domains of Fos and Jun or the subcellular sites of interactions between these domains . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos proteins heterodimerize with members of the Jun family to form active AP 1 transcription factor complexes . ^^^ In the present study , we took advantage of this property and generated transgenic mice , using the tetracycline gene regulation system , that support the inducible , brain region specific expression of a dominant negative mutant form of c Jun ( Deltac Jun ) , which can antagonize the actions of Fos proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
First , ACTH coordinately induces fos and jun gene families via activation of both ERK1 / 2 and cAMP / PKA pathways , resembling a mitogen . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Although Ref 1 provides the major AP 1 reducing activity in murine cells , ref 1 ( C64A ) cells retain normal levels of endogenous AP 1 DNA binding activity in vivo as well as normal Fos and Jun reducing activity in vitro . ^^^ The redox function of Ref 1 involves reduction of oxidized cysteine residues within the DNA binding domains of several transcription factors , including Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Since the proteins of the Fos and Jun families of immediate early genes dimerize to form activating protein ( AP ) 1 , the present study was conducted to examine the expression of Jun transcription factors in schizophrenic and control subjects . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Moreover , by using a competitive electromobility shift assay , we found that AP 1 , a Fos / Jun heterodimer , in HCS 2 / 8 was capable of binding not only to a typical AP 1 binding DNA fragment but also to the enhancer fragment of the ctgf gene . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We first assessed the effect of oxidant exposure on activator protein 1 ( c Jun and Fos ) and c Jun N terminal kinase ( JNK ) regulation in MLE 12 cells . ^^^ Both oxidants induced c Jun and Fos expression , albeit with a different pattern of regulation hyperoxia ( 95 % O 2 ) induced a biphasic response , whereas H2O2 ( 500 microM ) induced a sustained response . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Western blots for AP 1 and its signal mediators Erk and JNK showed that expression of Fos and JNK were decreased by the addition of FZFAT at 300 microg / ml , whereas Erk was not . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : From cDNA microarray screening of those specimens , several gene clusters , including Nos 2 and the transcription factors Fos , Fosl 1 , Jun and Nfkb 1 , were identified as possible upstream regulators of Na+ transport protein expression . ^^^ Gene expression for Fos was suppressed at both times , while that for Fosl 1 and Jun was augmented at 12 h and suppressed at 48 h . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Therefore , the transcription factor AP 1 and its subunits , proteins of the Jun and Fos proto oncogene families , are interesting targets for analysis in RA . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Autotransporters as scaffolds for novel bacterial adhesins : surface properties of Escherichia coli cells displaying Jun / Fos dimerization domains . ^^^ Hybrid proteins containing the beta autotransporter domain of the immunoglobulin A ( IgA ) protease of Neisseria gonorrhoea ( IgA beta ) and the partner leucine zippers of the eukaryotic transcriptional factors Fos and Jun were expressed in Escherichia coli . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Longitudinal transcriptional profiling revealed that simvastatin downregulated the inflammatory genes fos , jun , and tumor necrosis factor alpha and upregulated the cell cycle inhibitor p27Kip1 , endothelial nitric oxide synthase , and bone morphogenetic protein receptor type 1a . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factor , composed of Jun and Fos proteins , plays a crucial role in the fine tuning of cell proliferation . ^^^ We showed previously that AP 1 complexes are activated during the proliferative response that parallels the development of renal lesions after nephron reduction , but little is known about the specific role of individual Jun / Fos components in the deterioration process . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Microarray analysis and luciferase reporter assays indicate that adipokines specifically induce several transcriptional programs involved in promoting tumorigenesis , including increased cell proliferation ( IGF 2 , FOS , JUN , cyclin D 1 ) , invasive potential ( MMP 1 , ATF 3 ) , survival ( A 20 , NFkappaB ) , and angiogenesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recently , we reported on a C5a mutant , jun / fos A 8 , as a potent antagonist for the human and mouse C5a receptor ( CD 88 ) . ^^^ Replacements by either hydrophobic or negatively charged amino acids switched the CD 88 antagonist jun / fos A 8 to a CD 88 agonist . ^^^ A jun / fos A 8 mutant in which the jun / fos moieties and amino acids at positions 71 73 were deleted , A8Delta71 73 , blocked C5a and C5adesArg74 binding to CD 88 and C5L2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The nuclear transcription factor AP 1 , composed of dimers of Fos and Jun proteins , has been linked to a startling breadth of cellular events including cell transformation , proliferation , differentiation and apoptosis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The two types of cells share abundant transcripts of many genes , some of which are highly expressed in myeloid progenitors ( thymosin beta 4 and beta 10 , fos and jun ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The AP 1 ( activator protein 1 ) complex , which consists of proteins of the Fos and Jun families , is thought to play an important role in the balance between cell proliferation and apoptosis , the response to genotoxic stress and cell transformation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Up regulated genes in cardiac tissues included inflammatory and transcription activators FOS ; jun B proto oncogene ; nuclear receptor subfamily 4 , group A , member 3 ; MYC ; transcription factor 8 ; endothelial leukocyte adhesion molecule 1 ; and cysteine rich 61 ; apoptotic genes nuclear receptor subfamily 4 , group A , member 1 and cyclin dependent kinase inhibitor 1A ; and stress genes dual specificity phosphatase 1 , dual specificity phosphatase 5 , and B cell translocation gene 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The integrity of the sequence specific AP 1 element in StAR gene transcription was assessed using the AP 1 family members , Fos ( c Fos , Fra 1 , Fra 2 , and Fos B ) and Jun ( c Jun , Jun B , and Jun D ) , which demonstrated the involvement of Fos and Jun in StAR gene transcription to varying degrees . ^^^ Disruption of the AP 1 binding site reversed the transcriptional responses seen with Fos and Jun . ^^^ EMSA studies utilizing antibodies specific to Fos and Jun demonstrated the involvement of several AP 1 family proteins . ^^^ Functional assessment of Fos and Jun was further demonstrated by transfecting antisense c Fos , Fra 1 , and dominant negative forms of Fos ( A Fos ) and c Jun ( TAM 67 ) into MA 10 cells , which significantly ( P < 0 . 01 ) repressed transcription of the StAR gene . ^^^ Mammalian two hybrid assays revealed high affinity protein protein interactions between c Fos and c Jun with steroidogenic factor 1 , GATA 4 , and CCAAT / enhancer binding protein beta . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In fibroblasts , the expression of immediate early gene ( IEG ) encoded Fos , Jun , Myc , and early growth response gene 1 ( Egr 1 ) transcription factors is significantly extended by sustained extracellular signal regulated kinase 1 and 2 ( ERK 1 and 2 ) signaling . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun inhibit estrogen induced transcription of the human progesterone receptor gene through an activator protein 1 site . ^^^ We have identified an activating protein 1 ( AP 1 ) site at +745 in the human PR gene that bound purified Fos and Jun and formed a complex with Fos / Jun heterodimers present in MCF 7 nuclear extracts . ^^^ In support of this idea , transient transfection assays demonstrated that increasing levels of Fos and Jun repressed transcription of a reporter plasmid containing the +745 AP 1 site . ^^^ Fos levels were transiently increased , ERalpha levels were decreased , and Jun was dephosphorylated after MCF 7 cells were treated with estrogen . ^^^ Chromatin immunoprecipitation assays demonstrated that Jun was associated with the +745 AP 1 site in the endogenous PR gene in the presence and in the absence of estrogen , but that ERalpha and Fos were only associated with the +745 AP 1 site after estrogen treatment of MCF 7 cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos protein , a major component of the AP 1 transcription factor , is essential for osteoclast differentiation , acts as an oncogene , potentiates transforming signals , and controls invasive growth and angiogenesis during tumor progression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The tight junction protein ZO 2 associates with Jun , Fos and C / EBP transcription factors in epithelial cells . ^^^ We identified the existence of a specific interaction of ZO 2 with Fos , Jun and C / EBP ( CCAAT / enhancer binding protein ) . ^^^ To analyze if this association is present `` in vivo ' ' , we performed immunoprecipitation and immunolocalization experiments , which revealed an interaction of ZO 2 with Jun , Fos and C / EBP not only at the nucleus but also at the TJ region . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After 1 h of stimulation with PE , mRNA expression of c Fos and c Jun was upregulated to 185 + / 32 and 132 + / 13 % of control . ^^^ Fos and Jun proteins formed the AP 1 complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays identified binding of the transcription factors CREB and Fos at the CRE in AtT 20 cells , whereas CREB and cJun were detected in placental cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PKC activation induces the synthesis of the Fos and Jun proteins , known as the major components of activation protein 1 ( AP 1 ) transcriptional factor implicated in transcriptional control . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In adult mice , all seven Jun and Fos family members constituting the AP 1 complex were expressed more abundantly in the female gland than in the male gland , and JunD was the most abundant of the members . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The vitamin E deficiency mediated loss of AP 1 activity was not due to an alteration in the dimeric composition of constituent proteins , but rather to a general down regulation of steady state levels of members of the Fos and Jun families of proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here , we show that Aplidin induces c JUN , JUN B , JUN D , c FOS , FRA 1 and FOS B genes of the activator protein ( AP ) 1 family , and also p65 / RELA , a major component of nuclear factor kappa B ( NF kappaB ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The research in the field of AP 1 transcription factor expression , such as Jun or Fos proteins , in the brain was a milestone in neurosciences . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fugu Human Genome Synteny Viewer has been tested by comparing results with examples from a paper that includes a study of transcription factors , Fos and Jun encoding regions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Exposure to electric fields resulted in changes in Western blot patterns for the neuronal activity markers Fos , Fos B . and Jun in whole brain homogenate . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Whereas earlier studies have primarily demonstrated an early and transient transcriptional activation of members of the Fos , Jun , and Krox families , recent microarray studies investigating the delayed response could additionally identify several transcriptional repressors such as cAMP response element modulator ( CREM ) , IkappaB , silencer factor B , helix loop helix proteins , or glucocorticoid induced leucine zipper , indicating the attempt of the brain to re establish homeostasis after withdrawal induced excitation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel mobility shift analyses identified a short 40 nucleotide stretch of the promoter carrying AP 1 and HoxA 5 consensus motifs that responded with an altered shift pattern in THP 1 cells treated with oxLDLs , however , without evident involvement of either the Fos , Jun , Nrf 2 or HoxA 5 transcription factors . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In addition , expression of beta 4 integrin and in situ occupation of its promoter by AP 1 components , c Jun and Fos , was glucocorticoid dependent . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Members of AP 1 family , the Jun and fos related protein , have been shown to directly interact and form heterodimeric complexes . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Membrane depolarization of skeletal muscle cells induces slow inositol trisphosphate mediated calcium signals that regulate the activity of transcription factors such as the cAMP response element binding protein ( CREB ) , jun , and fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP 1 , essential for cell differentiation and immune and antioxidant defenses . ^^^ AP 1 activity is controlled , in part , by the redox state of critical cysteine residues within the basic regions of Jun and Fos . ^^^ AP 1 activity is controlled , in part , by the redox state of critical cysteine residues within the basic regions of Jun and Fos . ^^^ Mutation of these cysteines contributes to oncogenic potential of Jun and Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In contrast , Fos , a key component of AP 1 , is primarily transcriptionally regulated by serum responsive factors ( SRFs ) and ternary complex factors ( TCFs ) . ^^^ To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We have previously shown that peptides corresponding to the leucine zipper region of the Fos and Jun oncoproteins preferentially form heterodimeric coiled coils , and that simple principles involving electrostatic interactions are likely to determine the pairing specificity of coiled coils . ^^^ RESULTS : Based on studies of the Fos , Jun and GCN 4 leucine zippers , we have designed two peptides that are predominantly unfolded in isolation but which , when mixed , associate preferentially to form a stable , parallel , coiled coil heterodimer . ^^^ CONCLUSIONS : Our successful design strategy supports previous conclusions about the mechanism of interaction between the Fos and Jun oncoproteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Noncovalent multivalent assembly of jun peptides on a leucine zipper dendrimer displaying fos peptides . [ reaction : see text ] The synthesis and characterization of a new leucine zipper dendrimer ( LZD ) is reported that displays four copies of the peptide corresponding to the coiled coiled dimerization domain of Fos . ^^^ Circular dichroism spectroscopy , fluorescence titration , and sedimentation equilibrium experiments demonstrate that Fos LZD can noncovalently assemble four copies of the peptide corresponding to the coiled coil domain of Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Furthermore , when EGF receptor signalling was evaluated , by examination of mRNA expression for several EGF responsive genes ( EGF receptor , EGR 1 , Fos and Jun ) , it was observed that induced expression of REPS 2 exerts an inhibiting effect on this signalling . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
We show here that overexpression of p21SNFT in HepG 2 cells leads to repression of matrix metalloproteinase 1 by 70 80 % . p21SNFT interacted with Jun at the matrix metalloproteinase 1 promoter 88 Ets / AP 1 enhancer element , where Jun is known to activate transcription via interaction with Fos and Ets proteins . ^^^ When p21SNFT / Jun dimers bound the element in the presence of Ets , DNA was protected differently than when Fos was paired with Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The localization of Fos B , a member of transcription factor AP 1 family , in rat odontoblasts and pulpal undifferentiated ectomesenchymal cells . ^^^ The aim of this study was to compare the localization of Fos B , which is a component of AP 1 , in postmitotic differentiated and undifferentiated cells via Fos B immunoreactivity . ^^^ These findings suggest that Fos B , a component of AP 1 family , seems to have a negligible effect on differentiation and proliferation in odontoblasts and pulpal undifferentiated ectomesenchymal cells . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The 27 up regulated genes mainly encoded transcription factors ( JUN , EGR 1 , JUNB , FOS , FOSB , MYCN , and SNAIL 1 ) , growth factors ( VEGF , DTR / HB EGF , IGFBP 7 , IL 6 , ANGPT 2 , EREG , CCL3 / MIP1A , and CCL5 / RANTES ) and growth factor receptors ( TBXA2R , TNFRSF10A / TRAILR1 , and ROBO 2 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NO further completely abrogated IgE / Ag induced DNA binding activity of the nuclear AP 1 proteins Fos and Jun . ^^^ Nitric oxide inhibits IgE dependent cytokine production and Fos and Jun activation in mast cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) transcription factor dimers are composed of Jun , Fos , and ATF member proteins , but the mechanisms that determine AP 1 composition are not clearly defined and the function of specific dimers is not well understood . ^^^ Activator protein 1 ( AP 1 ) transcription factor dimers are composed of Jun , Fos , and ATF member proteins , but the mechanisms that determine AP 1 composition are not clearly defined and the function of specific dimers is not well understood . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
AP 1 is a dimer consisting of two Jun proteins ( homodimers ) or Jun and Fos proteins ( heterodimers ) . ^^^ Although the levels of particular Jun and Fos proteins do not decrease after glucocorticoid administration , the formation or DNA binding activity of some AP 1 dimers is specifically abolished . ^^^ AP 1 is a dimer consisting of two Jun proteins ( homodimers ) or Jun and Fos proteins ( heterodimers ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Proteins studied included cell surface receptors ( Ephrins and Eph receptors , CD 44 ) , kinases ( EGFR cytoplasmic domain , CDK 2 and 4 ) , proteases ( MMP 1 , CASP 2 ) , signal transduction proteins ( GRB 2 , RAF 1 , HRAS ) and transcription factors ( GATA 2 , Fli 1 , Trp 53 , Mdm 2 , JUN , FOS , MAD , MAX ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A Ras ( V 12 ) responsive element was mapped to the 5 ' leader sequence of the murine Dmp 1 promoter , where endogenous Fos and Jun family proteins bind . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Q RT PCR and Western blot in prospectively collected gastric mucosal samples confirmed the differential expression of Fos and Jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previously , we showed that the mRNA coding for Fra 1 , a FOS family member and an AP 1 transcription factor component , was highly expressed in the more invasive estrogen receptor negative ( ER ) breast cancer cell lines . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Deletion of the distal AP 1 site did not abrogate transcription driven by Fos / Jun , whereas a 2 bp mutation in the proximal AP 1 site significantly reduced pCx 43 transactivation by AP 1 dimers . ^^^ Transfection with c Jun or JunB had no effect on transcription from the Cx 43 promoter , whereas transfection with JunD or combinations of Jun and Fos family members led to significant increases in transcription . ^^^ Dimers comprising Fos / Jun proteins conferred greater transcriptional activity than Jun dimmers , with Fra 2 / JunB combination conferring greatest activity . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Estrogen signaling occurs through at least two distinct molecular pathways : ( 1 ) direct binding of liganded estrogen receptors ( ERs ) to estrogen responsive DNA elements ( EREs ) ( the `` ER / ERE pathway ' ' ) and ( 2 ) indirect recruitment of liganded ERs to activating protein 1 ( AP 1 ) responsive DNA elements via heterodimers of Fos and Jun ( the `` ER / AP 1 pathway ' ' ) . ^^^ Our studies indicate that ( 1 ) ERalpha / AP 1 complexes play a critical role in promoting the formation of stable RNA polymerase 2 preinitiation complexes leading to transcription initiation , ( 2 ) chromatin is a key determinant of estrogen and selective estrogen receptor modulator signaling in the ERalpha / AP 1 pathway , ( 3 ) distinct domains of ERalpha are required for recruitment to DNA bound Fos / Jun heterodimers and transcriptional activation at AP 1 sites , and ( 4 ) different enhancer / activator combinations in the ERalpha and AP 1 pathways use coactivators in distinct ways . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
At 2 4 hours after injury , genes such as Fos , Jun , and early growth response protein were up regulated , while genes responsible for intercellular adhesion were down regulated . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These repressed genes clustered mainly into classes involved in transcriptional regulation , signal transduction , immune and stress response , and apoptosis , as exemplified by genes encoding the transcription factors Myc , Jun , Fos , Ids , and CEBPs . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The variant EGFR ( HER 1 497K ) may lead to attenuation in ligand binding , growth stimulation , tyrosine kinase activation , and induction of proto oncogenes myc , fos , and jun . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
UVB radiation induced skin carcinogenesis is associated with the induction of activator protein 1 ( AP 1 ) signaling and factors , namely FOS and JUN family members . ^^^ In contrast , FOS and JUN proteins were transiently induced shortly after exposure to UVB radiation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The ATF 7 proteins , which are members of the cyclic AMP responsive binding protein ( CREB ) / activating transcription factor ( ATF ) family of transcription factors , display quite versatile properties : they can interact with the adenovirus E1a oncoprotein , mediating part of its transcriptional activity ; they heterodimerize with the Jun , Fos or related transcription factors , likely modulating their DNA binding specificity ; they also recruit to the promoter a stress induced protein kinase ( JNK 2 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Heat shock protein 90 is required for increased DNA binding activity of activator protein 1 , a heterodimer of Fos / JunD , in rheumatoid synovial cells under inflammatory stimuli . ^^^ Upon stimulation with inflammatory cytokines IL 1beta or TNFalpha , the AP 1 binding activity was further increased in rheumatoid synovial cells , and increased AP 1 protein was composed as heterodimers of Fos and JunD which was not known before as a major component of AP 1 in rheumatoid synovial cells . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Several genes were selected from p 53 related genes ( CDKN1A , TP53I11 and CDC 14 ) , Akt 2 related genes ( PRKCD , BRCA 1 , TRIB 3 and APPL ) , mitogen activated protein kinase related genes ( RSK and SH3BP5 ) , Ras superfamily genes ( RAP1GA1 , RHOC and ARHGDIA ) and AP 1 family and related genes ( RIP 140 , FOS , ATF 3 , JUN and FRA 2 ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Recent studies have identified several transcription factors such as c Jun , Fos and small Maf proteins that may play critical roles in the brain adaptation to hypercapnia . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Here we argue that this dismal outcome can be largely attributed to the fact that the potential of recently available neurobiological techniques has not been utilized , review some of these techniques and propose a step by step scenario for future research , concentrating on the heuristic potential of instrumentalizing inducible transcription factors ( ITFs ) such as Jun , Fos , Fos related antigens and Krox . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In order to identify novel binding partners of a alpha2beta1cytoplasmic domain complex , we have generated recombinant GST fusion proteins , incorporating the leucine zipper heterodimerization cassettes of Jun and Fos . ^^^ GST alpha 2 and GST Jun alpha 2 bound His tagged calreticulin while GST beta 1 and GST Fos beta 1 proteins bound talin . ^^^ In screening assays for novel binding partners , the immobilized GST Jun alpha2 / GST Fos beta 1 heterodimeric complex , but not the single subunits , interacted specifically with endothelial cell derived vimentin . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The assay uses the leucine zipper domains from the mammalian transcription factors Fos and Jun to force the interaction of two proteins . ^^^ With a target protein fused to the Jun zipper and a library of open reading frames fused to the Fos zipper , we demonstrate this approach in yeast with both a selection to identify membrane associated proteins and a selection to identify candidate components of the filamentous growth MAP kinase pathway . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
After 1 h or 96 h of treatment , Fos and Jun protein levels were altered and the DNA binding activity of AP 1 was increased in response to both substances . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Adult female rats were sacrificed by transcardial perfusion 2 h after infusion of graded doses of the monocarboxylate transporter inhibitor , alpha cyano 4 hydroxycinnamic acid ( 4 CIN ) , or vehicle into the caudal fourth ventricle , and tissue sections through the NTS / AP were processed by dual label immunofluorescence histochemistry for demonstration of cytoplasmic tyrosine hydroxylase ( TH ) and the inducible nuclear AP 1 regulatory factor , Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
ERK and p 38 MAP kinases , acting through the downstream mitogen and stress activated kinase 1 / 2 ( MSK1 / 2 ) , elicit histone H 3 phosphorylation on a subfraction of nucleosomes including those at Fos and Jun concomitant with gene induction . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , the effects of cocaine and BD 1063 on the expression of six fos and jun genes were evaluated in mouse brains using cDNA microarrays . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Fos and Jun , two components of the AP 1 transcription factor , are known to exert their function as a dimer and can therefore serve as a reference for dimer formation . ^^^ Expressing fusion proteins between Fos and the enhanced green fluorescent protein ( EGFP ) , as well as Jun and the monomeric red fluorescent protein 1 ( mRFP 1 ) in HeLa cells , we show here , for the first time , in vivo FCCS detection of protein protein interactions . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The fast activation of Jun and Fos proteins and other proteins encoding inducible transcription factors ( ITFs ) occurs in most tissues upon exposure to a variety of stressors including exposure to mitochondrial inhibitors . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Whereas elevated mRNA levels of the Fos gene could not be correlated with provirus presence , in one case , Northern blot analysis as well as quantitative real time PCR indicated proviral activation of the AP 1 super family member Batf , a gene not previously reported to be a target of insertional mutagenesis . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Previous in vitro studies have shown a transcriptional synergy between Erg protein , an Ets family member , and Jun / Fos heterodimer , members of the bZip family , which requires direct Erg Jun protein interactions . ^^^ For this purpose , we generated fusion proteins of Erg , Fos , and Jun with yellow and cyan fluorescent proteins , YFP and CFP , respectively . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Finally , the application of EGF to young cells resulted in increased phosphorylation of Fra 2 , a Fos protein component of the Jun / Fos heterodimer AP 1 complex . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
This was associated with increased DNA binding activities of the transcription factors Fos and Jun , and increased expression of a reporter gene driven by activator protein ( AP ) 1 binding elements in biotin deficient cells compared with physiological controls . ^^^ This study is consistent with the existence of clusters of biotin responsive proteins in distinct biological processes , including signaling by Fos / Jun ; the latter might mediate the proinflammatory and antiapoptotic effects of biotin deficiency . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 is composed of 2 proto oncogene families , namely Jun and Fos . ^^^ Activator protein 1 is composed of 2 proto oncogene families , namely Jun and Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Under multiple signaling pathways , Jun and Fos family proteins are known to play important roles as components of an AP 1 ( activator protein 1 ) complex , to regulate the transcription of various genes involved in cell proliferation , differentiation and programmed cell death . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Using AP 1 dependent reporter assays , we observed that Tam 67 and Tam / Fos mutants inhibited AP 1 transcriptional activity , while the Tam / Squelcher mutant did not . ^^^ These results suggest that Tam 67 suppresses breast cancer cell growth by interacting with Fos family members , specifically with cFos , to produce an inactive AP 1 complex . . ^^^ We created a Tam / Fos mutant in which the cJun dimerization domain was replaced by the cFos dimerization domain , and a Tam / Squelcher mutant in which the cJun dimerization domain was deleted . ^^^ In the present study , we used immunoprecipitation Western blotting to demonstrate that Tam 67 binds all Jun and Fos proteins in breast cancer cells . ^^^ In addition , we used two variants of the Tam 67 mutant to investigate whether Jun or Fos protein was required for breast cancer cell growth . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
METHODS : Using real time quantitative reverse transcriptase polymerase chain reaction ( [ q ] RT PCR ) , the authors examined 36 samples ( 30 melanomas , 4 benign nevi , and 2 reactive lymph nodes ) for the expression of 20 melanoma related genes that function in cell growth and differentiation ( epidermal growth factor receptor [ EGFR ] , WNT5A , BRAF , FOS , JUN , MATP , and TMP 1 ) , cell proliferation ( KI 67 , TOP2A , BUB 1 , BIRC 5 , and STK 6 ) , melanoma progression ( CD 63 , MAGEA 3 , and GALGT ) , and melanin synthesis ( TYR , MLANA , SILV , PAX 3 , and MITF ) . ^^^ RESULTS : Hierarchical clustering analysis of the expression data was able to distinguish between the melanoma and nonmelanoma samples and further stratified the melanoma samples into two groups differentiated by high expression of the genes involved in beta catenin activation ( EGFR and WNT5A ) and the MAPK / ERK pathway ( BRAF , FOS , and JUN ) . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
OBJECTIVES : Although several lines of evidence suggest that the overall effects of the ACTH receptor , melanocortin 2 receptor ( MC 2 R ) , mediated signal transduction on adrenocortical growth and tumorigenesis are anti proliferative , activation of MC 2 R induces mitogens like jun , fos , and myc and activates the MAPK pathway . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The cluster of genes whose up regulation was potentiated by GSH depletion included two HSPs ( HSP 40 and HSP 70 ) and the AP 1 transcription factor components Fos and FosB . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
A robust increase in expression of 10 immediate early genes including Egr 1 4 , Hes 1 , Junb , Jun and Fos was observed already after 1 h treatment with NGF alone . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The earliest genes induced consisted primarily of early response gene families ( Jun , Fos , Ier , Egr , growth arrest and DNA damage 45 ) and the inflammatory response element cyclooxygenase 2 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In summary , insertion of sequence 962 to 868 from the TRAP gene into the U 3 region of the MMLV LTR confers RANK L induced retroviral gene expression via Fos family protein interaction at AP 1 sites . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
To achieve this objective , full length coding sequences of chicken MHC class 2 B 21 and B 19 molecules were amplified and the molecules were expressed as fusion proteins , carrying Fos and Jun leucine zipper ( LZ ) , histidine tag and biotin ligase recognition site sequences , using a baculovirus expression system . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
In the present study , we examined the effect of the KD on the increase of PENK , Fos , Jun , AP 1 DNA binding activity and JNK gene expression induced by KA in the mouse hippocampus . ^^^ In addition , we have also found that KD diminished KA induced AP 1 DNA binding activity , Fos and Jun expression , and phoshorylated form of the three types of JNKs . ^^^ PENK is regulated by the c jun amino terminal kinase ( JNK ) signaling pathway , the crucial role of which is involved in the regulation of transcription factors , such as Jun and Fos . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Hence , the activities of several transcription / nuclear factors for inflammatory mediators ( NF kappaB , NFAT ) are markedly reduced , while those of others ( Jun , Fos , Fra , p90rsk ) are unaltered . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
PTHrP increased mRNA and protein levels of all Fos members , but only one Jun member ( JunB ) was increased . ^^^ RESULTS : PTHrP treatment in vitro resulted in a time dependent upregulation of mRNA and proteins for the Fos family members , but only JunB of the Jun family . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Jun proteins Jun , JunB and JunD are core members of activator protein 1 ( AP 1 ) , a dimeric transcription factor complex consisting of homo and heterodimers of the Jun , Fos , activating transcription factor ( ATF ) and musculoaponeurotic fibrosarcoma ( Maf ) families . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factor AP 1 , which is composed of Fos and Jun family proteins , plays an essential role in tumor cell invasion by altering gene expression . ^^^ We report here that Krp 1 , the AP 1 up regulated protein that has a role in pseudopodial elongation in 5 Fos transformed rat fibroblast cells , forms a novel interaction with the nondifferentially expressed actin binding protein Lasp 1 . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Especially noteworthy and potentially significant in the progression program were the deregulation of the WNT / beta catenin pathway , the decreased expression of Jun B and Fos , alternative kinase deregulation , such as Arg ( Abl 2 ) , and an increased expression of PRAME . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
These signaling pathways lead to the enhanced ability of Jun and Fos family members ( i . e . , components of the activator protein [ AP ] 1 transcription factor ) to activate transcription of a number of AP 1 dependent target genes involved in cell proliferation or death , differentiation , and inflammation . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Analysis of this cooperativity in vitro shows that ( 1 ) many different spatial arrangements of the Ets and AP 1 sites support cooperative binding , ( 2 ) the bZIP motifs of Fos and Jun are sufficient to support this cooperativity , and ( 3 ) both the Ets domain and carboxy terminal sequences of Fli 1 are important for cooperative DNA binding . ^^^ Here we show that those Ets family proteins that participate in Ewing ' s sarcoma , including Fli 1 , ERG , and ETV 1 , cooperatively bind these tandem elements with Fos Jun while other Ets family members do not . ^^^ EWS Fli 1 activates the expression of UPP mRNA , is directly bound to the UPP promoter , and transforms 3T3 fibroblasts ; in contrast , a C terminally truncated mutant form of EWS Fli 1 that can not cooperatively bind DNA with Fos Jun is defective in all of these properties . ^^^ The results show that the ability of EWS Ets proteins to cooperatively bind DNA with Fos Jun is critical to the biologic activities of these proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Gel shift assay and Western blotting revealed that elimination of Fos expression significantly reduced both AP 1 DNA binding activity and PPE expression in the ipsi MVN after UL . ^^^ All these findings suggest that , immediately after UL , Fos induced in some of the ipsi MVN neurons could regulate consequent PPE expression via the AP 1 activation and facilitate the restoration of balance between bilateral MVN activities via the opioid receptor activation , resulting in progress of vestibular compensation . . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Perturbations in the expression levels of the proto oncogenes FOS , JUN and MYC after exposure to sham and RF fields were assessed by real time RT PCR . ^^^ However , concurrent positive ( heat shock ) control samples displayed a significant elevation in the expression of HSP 27 , HSP 70 , FOS and JUN . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Treatment of the non neoplastic , immortalized human breast epithelial MCF 10F cells with these low concentrations of genistein was associated with decreased cell proliferation , down regulation of the protooncogene MET , up regulation of the breast tumor suppressor gene EGR 1 , and up regulation of the immediate early response genes FOS and JUN . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
Members of the inducible transcription factor Fos family , that are part of the AP 1 complex that binds to the corresponding promoter site , are implicated in the regulation of gene transcription after acute and chronic seizures . ^^^ In this study , the AP 1 binding capacity , its content of different Fos proteins , and the anatomical specificity , were analyzed 2 or 18 h after achieving full kindling in rats . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The transcription factor activator protein 1 ( AP 1 ) consists of a variety of dimers composed of members of the Jun and Fos families of proteins . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
The Fos protein , a major component of the AP 1 transcription factor , is essential for osteoclast differentiation , acts as an oncogene , potentiates transforming signals and controls invasive growth and angiogenesis during tumor progression . ^^^
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01100 and P05412	Pubmed	SVM Score :0.0
NA