| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| The involvement of the Ah receptor , Maf , Nrl , Jun , Fos , and NF kappa B in GST induction is discussed . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| The deduced amino acid sequence of the 5 maf gene product contains a `` leucine zipper ' ' motif similar to that found in a number of DNA binding proteins , including the gene products of the fos , jun , and myc oncogenes . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| However , neither Fos nor Jun , either alone or in combination with each other or c Maf , altered transcription from this element . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF E 2 transcription factor . ^^^ The maf oncogene encodes a bZip nuclear protein which recognizes sequences related to an AP 1 site either as a homodimer or as heterodimers with Fos and Jun . ^^^ This study shows that the small Maf proteins can also dimerize among themselves and with Fos and a newly identified p 45 related molecule ( Ech ) but not with 5 Maf or Jun . ^^^ Although the small Maf proteins preferentially recognize the consensus NF E 2 sequence as heterodimers with either NF E 2 p45 , Ech , or Fos , these heterodimers seemed to be different in their transactivation potentials . ^^^ These results raise the possibility that tissue specific gene expression and differentiation of erythroid cells are regulated by competition among Fos , NF E 2 p45 , and Ech for small Maf proteins and for binding sites . . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| MafB , a new Maf family transcription activator that can associate with Maf and Fos but not with Jun . ^^^ In addition , MafB forms heterodimers with 5 Maf and Fos through its zipper structure . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| The c maf proto oncogene and the neural retina specific gene nrl encode members of a subfamily of bZIP proteins that form heterodimers with Fos and Jun . ^^^ We have determined the DNA binding specificities of various homo and heterodimeric combinations among Nrl , Maf , Fos and Jun . ^^^ Fos Nrl , Jun Nrl and Fos Maf heterodimers bound to nonpalindromic recognition sequences with the consensus sequence TGAC ( N ) 3 4GCA . ^^^ These results indicate that Nrl and Maf have a DNA binding specificity distinct from that of Fos and Jun , and that each subunit in the dimer independently recognizes one half of the recognition sequence . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Maf and Nrl can bind to AP 1 sites and form heterodimers with Fos and Jun . ^^^ Maf and Nrl were also able to form heterodimers with Fos and Jun in vitro . ^^^ All pairwise combinations of Maf , Nrl , Fos and Jun could be co immunoprecipitated by antisera directed against either subunit . ^^^ These results indicate that Maf and Nrl together with Fos and Jun family proteins form a bZIP protein superfamily whose members can form an array of heterodimers that have overlapping DNA binding specificities . . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Maf nuclear oncoprotein recognizes sequences related to an AP 1 site and forms heterodimers with both Fos and Jun . ^^^ Furthermore , Maf efficiently formed heterodimers with the components of AP 1 , Fos and Jun , through their leucine zipper structures , and these heterodimers show binding specificities distinct from those for Maf Maf and Jun Jun homodimers . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Transactivation activity of Maf nuclear oncoprotein is modulated by Jun , Fos and small Maf proteins . ^^^ Co expression of Jun or Fos also affected the transactivation potential of Maf by forming Maf / Jun or Maf / Fos heterodimers of distinct DNA binding specificities . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| We show here that the TCF 11 protein interacts to form heterodimers with small Maf proteins , previously shown to dimerize with p 45 NF E 2 , ECH and Fos . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| It is shown that dimer forming specificities of Maf 1 and Maf 2 to Jun or Fos family proteins are variable . ^^^ Maf 1 efficiently forms heterodimers with Fos family proteins . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Maf 2 heterodimerizes with c Fos . ^^^ We have also found that heterodimer formation of Maf 2 with c Fos dramatically changes the specificity of DNA binding and trans activation activity from that of the Maf 2 homodimer . ^^^ In contrast to 5 Maf which forms heterodimers with all Jun and Fos proteins , Maf 1 heterodimerizes with all four Fos proteins , but not at all with the three Jun proteins . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| MafA is able to bind to MARE sequence and to heterodimerize with 5 Maf , MafB , Jun and Fos , but not with the small MafF and MafK proteins . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Maf is a basic domain / leucine zipper domain protein originally identified as a proto oncogene whose consensus target site in vitro , the T MARE , is an extended version of an AP 1 site normally recognized by Fos and Jun . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Many transcription factors , including Nrf , Jun , Fos , Fra , Maf , YABP , ARE BP 1 , Ah ( aromatic hydrocarbon ) receptor , and estrogen receptor bind to the ARE from the various genes . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| However , two other bZip oncoproteins , Fos and Jun , failed to associate with the Hox proteins , while a distantly related Hox family member , Meis 1 , could not interact with Maf . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Antibody supershift electrophoretic mobility shift assays did not detect Jun , Fos , or ATF / CREB proteins but identified Nrf 2 and the small Maf protein , MafG , as components of complex 10 . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Since the MARE contains a consensus TRE sequence recognized by AP 1 , Jun and Fos family members may act to compete or interfere with the function of CNC small Maf heterodimers . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Dominant negative mutants of Nrf 2 and Maf , but not of c Fos and c Jun , inhibited basal and heme induced expression of an E 1 controlled luciferase gene . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Recent studies have identified several transcription factors such as c Jun , Fos and small Maf proteins that may play critical roles in the brain adaptation to hypercapnia . ^^^ |
|
| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| The Jun proteins Jun , JunB and JunD are core members of activator protein 1 ( AP 1 ) , a dimeric transcription factor complex consisting of homo and heterodimers of the Jun , Fos , activating transcription factor ( ATF ) and musculoaponeurotic fibrosarcoma ( Maf ) families . ^^^ |
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| Interacting proteins: O75444 and P01100 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitation assays showed that the prototype redox sensitive transcription factors , Nrf 2 , small Maf protein ( s ) , and c Fos , were recruited to this promoter in VPA treated cells . ^^^ |
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