| Interacting proteins: O75030 and P01100 |
Pubmed |
SVM Score :0.0 |
| Microphthalmia associated transcription factor interacts with PU . 1 and c Fos : determination of their subcellular localization . ^^^ We found normal MITF ( + MITF ) c Fos and mi MITF c Fos complexes in the cytoplasm by immunoblotting , and showed that PU . 1 bound with both + MITF and mi MITF using an electrophoretic mobility shift assay . ^^^ Furthermore , the nuclear localization of PU . 1 and c Fos was inhibited by over expressed mi MITF in WEHI 3 cells . ^^^ These results indicate that mi MITF expressing in osteoclasts specifically binds to c Fos and PU . 1 which are essential transcription factors of osteoclastgenesis and that mi MITF blocks the nuclear localization of these other transcription factors , which may result in osteopetrosis in mi / mi mutant mice . . ^^^ |
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| Interacting proteins: O75030 and P01100 |
Pubmed |
SVM Score :0.0 |
| Some ubiquitously expressed genes seem unexpectedly to have unique functions that are largely confined to bone cells : M CSF , C Fos , PU . 1 , and NF kappaB are required for osteoclast formation , whereas c Src and Mitf ( microphthalmia transcription factor ) are required for osteoclast activity after the cells have formed . ^^^ |
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| Interacting proteins: O75030 and P01100 |
Pubmed |
SVM Score :0.0 |
| STAT 3 and MITF cooperatively induce cellular transformation through upregulation of c fos expression . ^^^ Microarray analysis revealed that c fos is highly expressed in transformants expressing STAT3C and MITF . ^^^ Promoter analysis and chromatin immunoprecipitation assay suggested that both STAT 3 and MITF can cooperatively upregulate the c fos gene . ^^^ These data indicate that MITF and STAT 3 cooperatively induce c fos , resulting in cellular transformation . . ^^^ |
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| Interacting proteins: O75030 and P01100 |
Pubmed |
SVM Score :0.0 |
| Recent molecular genetic studies have identified several transcription factors , such as NF kappaB , c Fos , MITF , and NFATc 1 , which are essential for osteoclast differentiation . ^^^ |
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| Interacting proteins: O75030 and P01100 |
Pubmed |
SVM Score :0.0 |
| By quantitative RT PCR , sMCs expressed lower levels of c fos , PU . 1 , C / EBPalpha , and C / EBPepsilon than monocytes and granulocytes , but higher levels of MITF , SCL , GATA 1 and GATA 2 . ^^^ At the protein level , MITF , SCL , GATA 2 , Elf 1 and c fos were clearly detectable in sMCs . ^^^ |
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| Interacting proteins: O75030 and P01100 |
Pubmed |
SVM Score :0.0 |
| METHODS : Using real time quantitative reverse transcriptase polymerase chain reaction ( [ q ] RT PCR ) , the authors examined 36 samples ( 30 melanomas , 4 benign nevi , and 2 reactive lymph nodes ) for the expression of 20 melanoma related genes that function in cell growth and differentiation ( epidermal growth factor receptor [ EGFR ] , WNT5A , BRAF , FOS , JUN , MATP , and TMP 1 ) , cell proliferation ( KI 67 , TOP2A , BUB 1 , BIRC 5 , and STK 6 ) , melanoma progression ( CD 63 , MAGEA 3 , and GALGT ) , and melanin synthesis ( TYR , MLANA , SILV , PAX 3 , and MITF ) . ^^^ |
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