| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| Cystatin A bound tightly and rapidly to papain and cathepsin L , with dissociation equilibrium constants of approximately 10 ( 11 ) 10 ( 13 ) M and association rate constants of 3 10 10 ( 6 ) 5 10 10 ( 6 ) M 1 . s 1 . ^^^ |
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| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| Linkage between phosphorylated cystatin alpha and filaggrin by epidermal transglutaminase as a model of cornified envelope and inhibition of cathepsin L activity by cornified envelope and the conjugated cystatin alpha . ^^^ The conjugated protein and purified cornified envelope showed an inhibitory effect against papain and cathepsin L , but cathepsin B and H were not inhibited by these P cystatin alpha conjugates . ^^^ Although the component protein , P cystatin alpha itself , inhibited cathepsin H strongly , these conjugated proteins inhibited specifically the cathepsin L family . ^^^ |
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| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly 4 mutants with papain , cathepsin B , and cathepsin L . ^^^ |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| The contribution of N terminal region residues of cystatin A ( stefin A ) to the affinity and kinetics of inhibition of papain , cathepsin B , and cathepsin L . ^^^ These differential effects indicate that the N terminal portion of cystatin A primarily functions by stabilizing the complexes with enzymes having easily accessible active site clefts , e . g . , papain and cathepsin L . ^^^ |
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| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : We examined cathepsin L activity , expression of cystatin A , and copper and zinc containing superoxide dismutase in human chronic otitis media . ^^^ No relationships were found between cystatin A expression and grade of cathepsin L activity . ^^^ |
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| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors . ^^^ Cathepsin L , a cysteine proteinase , and cystatin A , an inhibitor of cysteine proteinases , are thought to regulate the invasion and metastasis of malignant cells . ^^^ In this study , the expression of cathepsin L and cystatin A in skin tumors was investigated immunohistochemically in order to examine the relationship between these two enzymes in the pathophysiology of malignant cells . ^^^ Formalin fixed and paraffin embedded specimens from normal skin , seborrheic keratoses , and squamous cell carcinomas were reacted with polyclonal antibodies against rat cathepsin L or cystatin a which cross react to human cathepsin L and cystatin A , respectively . ^^^ In well differentiated squamous cell carcinoma ( SCC ) ( 9 cases ) , staining for cathepsin L and cystatin A was moderately positive in differentiated tumor cells and negative in undifferentiated SCC ( 5 cases ) . ^^^ |
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| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| Bovine stefin A bound tightly and rapidly to cathepsin L ( kass = 9 . 6 10 10 ( 6 ) M 1 . s 1 , Ki = 29 pM ) . ^^^ |
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| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| In this study we investigated the levels of two lysosomal cysteine protease proteins cathepsin B ( CB ) and cathepsin L ( CL ) and the levels of three cysteine protease inhibitor proteins stefin A ( SFA ) , stefin B ( SFB ) and cystatin C ( CNC ) in squamous cell lung carcinoma ( SQCLC ) and matched lung parenchyma specimens and examined the inhibition of CB and cathepsin C ( CC ) activities by endogenous inhibitors in extracts from SQCLC , lung adenocarcinoma ( LAC ) and lung parenchyma specimens . ^^^ |
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| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| Our purpose was to analyze the predictive relevance of DNA ploidy , S phase fraction ( SPF ) , and tissue levels of lysosomal proteinases cathepsin D ( CD ) , cathepsin B ( CB ) , cathepsin L ( CL ) , and urokinase type plasminogen activator ( uPA ) and that of the intracellular cysteine proteinase inhibitor stefin A on clinical outcome . ^^^ |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| Comparison of potential biological markers cathepsin B , cathepsin L , stefin A and stefin B with urokinase and plasminogen activator inhibitor 1 and clinicopathological data of breast carcinoma patients . ^^^ Enzyme linked immunosorbent assays ( ELISAs ) were used to measure cysteine cathepsin B ( CatB ) and cathepsin L ( CatL ) and their inhibitors , stefin A ( StA ) and stefin B ( StB ) , together with urokinase ( u PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , in 150 cytosols of primary invasive breast carcinoma . ^^^ |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01040 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|