| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| Cathepsin S was strongly inhibited by cystatins A and B in the subnanomolar range and by cystatin C in the picomolar range . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| In contrast , for cathepsin S inhibition these interactions are of lesser significance , as reflected by a Ki value of 10 ( 8 ) M for the cystatin C variant devoid of Arg 8 , Leu 9 , Val 10 , and Trp 106 side chains . ^^^ The Leu 9 side chain confers selectivity to the inhibition of the target peptidases ; it contributes to cathepsin B and L affinity by factors of 200 and 50 , respectively , to cathepsin S binding by a factor of 5 only , and results in a 10 fold decreased affinity between cystatin C and cathepsin H . . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| By comparison with corresponding results for wild type cystatins C and D , it was concluded ( 1 ) that both the N terminal and framework part of the molecules significantly contribute to the observed differences in inhibitory activities of cystatins C and D and ( 2 ) that the N terminal segment of cystatin C increases the inhibitory activity of cystatin D against cathepsin S and cathepsin L but results in decreased activity against cathepsin H . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| The t1 / 2 of SCCA 1 cathepsin S complexes was > 1155 min , whereas that of cystatin C cathepsin complexes was 55 min . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| Cathepsin S is not controlled transcriptionally but by a novel mechanism involving alterations in the expression and localization of an endogenous cathepsin S inhibitor cystatin C . ^^^ Thus , the ratio of cystatin C to cathepsin S in developing DCs helps to determine the fate of newly synthesized MHC class 2 molecules . . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| Cystatin C is a cysteine protease inhibitor that regulates the activity of cathepsin S , a protease with central regulatory functions in retinal pigment epithelial cells . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| It has been proposed that the cysteine protease inhibitor cystatin C ( CyC ) plays a pivotal role in the control of this process by regulating the activity of cathepsin S , a protease involved in removal of the MHC 2 chaperone 2 , and hence in the formation of MHC 2 peptide complexes . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expressions of cathepsin S and K and their inhibitor cystatin C were examined during arterial remodeling using a rat carotid artery balloon injury model . ^^^ Western blotting analysis revealed that both cathepsin S and K protein levels also increased in the carotid arteries during neointima formation , coinciding with an increase elastolytic activity assayed using Elastin Congo red , whereas , no significant change in the expressions of cystatin C mRNA and protein was observed during follow up periods after injury . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| We have demonstrated enhanced elastolytic cathepsin S in human atherosclerotic lesions but insufficient amounts of its endogenous inhibitor cystatin C , suggesting alterations of serum cathepsin S and / or cystatin C in patients with atherosclerosis or diabetes . ^^^ In this study , we measured levels of both cathepsin S and cystatin C in sera from 240 patients by ELISA . ^^^ Multiple linear regression analysis demonstrated that significantly higher serum levels of cathepsin S in patients with either atherosclerotic stenosis ( p < 0 . 04 ) or diabetes ( p=0 . 0005 ) persisted after adjustment for cystatin C level , renal function , smoking , and serum glucose levels ( p=0 . 008 , p=0 . 0005 ) . ^^^ Furthermore , patients with acute ( p=0 . 009 ) or previous myocardial infarction ( p < 0 . 02 ) or unstable angina pectoris ( p < 0 . 05 ) had elevated levels of cathepsin S after adjustment for smoking , creatinine , cystatin C , and serum glucose . ^^^ Although the pathophysiology of cathepsin S or cystatin C in atherosclerosis and diabetes requires further investigation , increased serum cathepsin S may serve as a biomarker for both diseases . . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| Overexpression of cystatin C suppressed IL 6 STAT 3 mediated increase of cathepsin S activity and reduction of MHCII alphabeta dimer , 2 , and H 2 DM levels in DCs . ^^^ |
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| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| By using a mouse model of multistage murine pancreatic islet cell carcinogenesis in which cysteine cathepsin activity has been functionally implicated , we demonstrated that selective cathepsin S deficiency impaired angiogenesis and tumor cell proliferation , thereby impairing angiogenic islet formation and the growth of solid tumors , whereas the absence of its endogenous inhibitor cystatin C resulted in opposite phenotypes . ^^^ Although mitogenic vascular endothelial growth factor , transforming growth factor beta 1 , and the anti angiogenic endostatin levels in either serum or carcinoma tissue extracts did not change in cathepsin S or cystatin C null mice , tumor tissue basic fibroblast growth factor and serum type 1 insulin growth factor levels were higher in cystatin C null mice , and serum type 1 insulin growth factor levels were also increased in cathepsin S null mice . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| Both cathepsin S and cystatin C were present in bony areas of the valves , whereas cathepsin 5 localized to endothelial cells in areas rich of neovascularization . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| CTSS activity was maximal in preadipocyte culture medium but decreased thereafter , fitting with increased release of the CTSS endogenous inhibitor , cystatin C , during differentiation . ^^^ |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25774 and P01034 |
Pubmed |
SVM Score :0.0 |
| NA |
|