| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.62717501 |
| Interactions between ovine cathepsin L , cystatin C and alpha 2 macroglobulin . 0.62717501^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemical study of cathepsin L and rat salivary cystatin 3 in rat osteoclasts treated with E 64 in vivo . ^^^ The localization of cathepsin L and rat salivary cystatin 3 ( RSC 3 ) in rat osteoclasts ( rat femoral and alveolar bones ) treated with or without E 64 ( control ) was examined immunocytochemically . ^^^ |
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| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| The contribution of the kininogens and cystatin C to the functional inhibitory capacity for cysteine proteinases of blood plasma and inflammatory secretions was estimated from ex vivo experiments . 98 . 5 % of the inhibitory capacity of blood plasma for cathepsin L ( 4 5 microM ) is provided by the kininogens ensuring a complete control of this enzyme even at a lowered kininogen concentration . ^^^ |
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| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| Interactions from the side chains of residues in the N terminal binding region and Trp 106 are jointly responsible for the major part of cystatin C affinity for cathepsin L and are also of considerable importance for cathepsin B and H affinity . ^^^ |
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| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| The results demonstrate that 1 ) cystatin D has a characteristic inhibition profile since it does not inhibit cathepsin B ( Ki > 1 microM ) , and when compared to cystatin C and all other known cystatins it is a much poorer inhibitor of cathepsin L ( mean Ki 25 nM ) but binds cathepsin H and S relatively tightly ( mean Ki values of 8 . 5 and 0 . 24 nM , respectively ) ; and 2 ) the inhibitory activities of the two cystatin D variants are not significantly different , demonstrating that the presence of an extra cysteine residue in the cystatin D molecule affects neither the stability nor the functional activity of the inhibitor , thus explaining the widespread distribution of the Cys 26 cystatin D encoding allele in the population . ^^^ |
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| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| These data suggest that the role of cystatin C in the testis may be to inhibit the proteolytic activity of the cysteine protease cathepsin L in all stages except stages 6 VII . . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| The subsequent reduction in cathepsin L expression after this transient increase was accompanied by a concomitant increase in cystatin C expression . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| By comparison with corresponding results for wild type cystatins C and D , it was concluded ( 1 ) that both the N terminal and framework part of the molecules significantly contribute to the observed differences in inhibitory activities of cystatins C and D and ( 2 ) that the N terminal segment of cystatin C increases the inhibitory activity of cystatin D against cathepsin S and cathepsin L but results in decreased activity against cathepsin H . ^^^ |
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| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| The mature recombinant protein processed by insect cells had an N terminal segment 7 residues longer than that of cystatin C and displayed reversible inhibition of papain and cathepsin L ( Ki = 1 . 1 and 0 . 31 nM , respectively ) , but not cathepsin B . ^^^ |
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| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| The concentrations of immunologically detected cathepsin L and cystatin C , but not cathepsin B , were significantly increased in BAL fluid from the smokers with emphysema compared with those without emphysema , although the activity of cathepsin L , measured using a synthetic substrate and cathepsin L , released from cultured alveolar macrophages at 24 h , did not show any significant difference between the two groups . ^^^ In conclusion , increased levels of cathepsin L and cystatin C were demonstrated in bronchoalveolar lavage fluid from subjects with subclinical emphysema . ^^^ |
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| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| In this study we investigated the levels of two lysosomal cysteine protease proteins cathepsin B ( CB ) and cathepsin L ( CL ) and the levels of three cysteine protease inhibitor proteins stefin A ( SFA ) , stefin B ( SFB ) and cystatin C ( CNC ) in squamous cell lung carcinoma ( SQCLC ) and matched lung parenchyma specimens and examined the inhibition of CB and cathepsin C ( CC ) activities by endogenous inhibitors in extracts from SQCLC , lung adenocarcinoma ( LAC ) and lung parenchyma specimens . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| Notably , the affinity of bovine cystatin C for cathepsin H was somewhat weaker than that of human cystatin C , and bovine cystatin C bound to cathepsin L with about a four fold higher association rate constant than the human inhibitor . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| Cathepsin L is capable of truncating cystatin C of 11 N terminal amino acids . ^^^ Such truncation of cystatin C is recorded after action of glycyl endopeptidase and cathepsin L . ^^^ Isoelectric focusing of the cathepsin L and cystatin C mixture showed the formation of two new bands . ^^^ One of them appeared whether E 64 or PMSF was added or not , evidently representing a cystatin C / cathepsin L complex . ^^^ N terminal sequencing after separation by HPLC showed that cystatin C is cleaved by cathepsin L at the Gly 11 Gly12 bond . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| A study was performed to correlate the expression of junctional complex components ( such as zonula occludens 1 [ ZO 1 ] , a tight junction component protein ) and nonjunctional complex components ( such as urokinase type plasminogen activator [ uPA ] , a serine protease ; cathepsin L , a cysteine protease ; alpha 2 macroglobulin , a nonspecific protease inhibitor ; and cystatin C , a cysteine protease inhibitor ) at the time when inter Sertoli tight junctions were established in vitro . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| Reactivity to anti cystatin C and anti cathepsin L antibodies was also detected in the apical bud of newborn rat incisors . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| Cystatin C ( CST 3 ) is a secreted inhibitor of lysosomal cysteine proteases cathepsins B ( CTSB ) and CTSL , which are abundant in the ovine endometrium and conceptus . ^^^ Cystatin C ( CST 3 ) is a secreted inhibitor of lysosomal cysteine proteases cathepsins B ( CTSB ) and CTSL , which are abundant in the ovine endometrium and conceptus . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| The present study examined the effects of basic fibroblast growth factor ( bFGF ) , transforming growth factor beta 1 ( TGF beta 1 ) and platelet derived growth factor ( PDGF ) on the secretion of proteinases [ cathepsin L and matrix metalloproteinases ( MMPs ) ] and their inhibitors [ cystatin C and tissue inhibitor of metalloproteinase 2 ( TIMP 2 ) ] from differentiated podocytes in culture . ^^^ The secretion of cathepsin L , cystatin C and TIMP 2 from differentiated podocytes were shown by immunoblot analysis . ^^^ RESULTS : Expression of mRNAs for receptors of the growth factors , the proteinases and their inhibitors were confirmed . bFGF increased the secretion of cathepsin L ( 5 . 04 fold at 20 ng / mL ) , but did not alter the secretion of its extracellular inhibitor , cystatin C . ^^^ PDGF only slightly increased the secretion of cathepsin L ( 2 . 54 fold at 20 ng / mL ) but exerted no effect on the secretion of cystatin C , MMPs , and TIMP 2 from differentiated podocytes . ^^^ |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01034 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|