| Interacting proteins: P01024 and Q07954 |
Pubmed |
SVM Score :0.0 |
| The nucleotide sequences of the lrp and lrp 1 genes differ by only a single nucleotide , a C to G change that would substitute a Glu for an Asp at amino acid 114 . ^^^ |
|
| Interacting proteins: P01024 and Q07954 |
Pubmed |
SVM Score :0.0 |
| LRP expression was weakly but significantly related to in vitro resistance to DNR ( Spearman ' s rank correlation coefficient 0 . 25 , P = . 016 ) but not to VCR , VP 16 , PRD , and ASP . ^^^ |
|
| Interacting proteins: P01024 and Q07954 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that surface exposed aspartic acid and tryptophan residues at identical positions in the two homologous domains , CR 5 and CR 6 ( Asp ( 958 , CR 5 ) , Asp ( 999 , CR 6 ) , Trp ( 953 , CR 5 ) and Trp ( 994 , CR 6 ) ) , are critical for the binding of the complex as well as for the binding of the receptor associated protein ( RAP ) the folding chaperone / escort protein required for transport of LRP to the cell surface . ^^^ |
|
| Interacting proteins: P01024 and Q07954 |
Pubmed |
SVM Score :0.0 |
| The different mechanisms of binding to RAP domains 1 and 3 are further substantiated by the different effects on binding of mutations of the Asp and Trp residues in the LRP CR 5 or CR 6 domains , which are important for the recognition of several ligands . . ^^^ |
|
| Interacting proteins: P01024 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Molecular dynamics simulation of the complex formation between the catalytic domain of APR and the S2D mutant showed that the carboxyl of Asp 2 interacts with the catalytic zinc , thereby partially neutralizing the negative charge that otherwise would clash with the carboxyl group of Glu 177 of APR . ^^^ |
|
| Interacting proteins: P01024 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01024 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01024 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
|