| Substitution by Asp does not influence the rate of tRNA and rRNA degradation but alters specificity even more markedly than the other mutations : T44D angiogenin has 17 40 fold decreased activity toward CpN ' dinucleotides and 1 . 3 1 . 9 fold increased activity toward UpN ' , resulting in an inverted order of preference ( U > C ) compared to native angiogenin . ^^^ |