| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.79253114 |
| Matriptase , a membrane bound serine protease , was shown to activate uPA in a uPA receptor free , solution based study . 0.79253114^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :1.0006063 |
| Initiation of plasminogen activation on the surface of monocytes expressing the type 2 transmembrane serine protease matriptase . uPA ( urokinase type plasminogen activator ) activates plasminogen with high efficiency when bound to its cellular receptor uPAR , but only after a prolonged lag phase during which generated plasmin activates pro uPA . 1.0006063^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| Various proteases reportedly cleave scHGF to generate the active two chain form ( HGF ) , including u PA ( urokinase type plasminogen activator ) , t PA ( tissue type plasminogen activator ) , kallikrein , Factor XIa , Factor XIIa , HGF activator and matriptase . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| HGF activator ( HGFA ) , matriptase , urokinase type plasminogen activator and hepsin are the main factors responsible for converting pro HGF into active HGF . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| Five proteases were identified : urokinase type plasminogen activator , factor 12 , protein C , trypsinogen 4 , and a protease that we refer to as membrane type serine protease 1 ( MT SP 1 ) . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| Cellular localization of membrane type serine protease 1 and identification of protease activated receptor 2 and single chain urokinase type plasminogen activator as substrates . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| Competitive phage display selection yielded a Pkal inhibitor with an apparent dissociation equilibrium constant ( K ( 1 ) * ) of 11 pM , whereas K ( 1 ) * values for related proteases ( such as Factor Xa ( FXa ) , Factor XIa ( FXIa ) , urokinase type plasminogen activator ( uPA ) , thrombin , and membrane type serine protease 1 ( MT SP 1 ) ) were four to seven orders of magnitude higher . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| To establish an introductory understanding of the quantitative mRNA expression of MT SP 1 and to correlate these levels with urokinase type plasminogen activator receptor ( uPAR ) , a key component of extracellular proteolysis , quantitative RT PCR was carried out . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| When ESb MP cells were cultured in the presence of inhibitors of MTSP 1 , such as antithrombin 3 , Pro Phe Arg chloromethylketone , or aprotinin , the ratio of endogenously activated murine u PA to inactive pro u PA in conditioned medium was significantly reduced ( from 80 % to 15 % ) . ^^^ These results suggest a novel autocrine mechanism of plasmin independent pro u PA activation for metastatic T lymphomas by the production of an MTSP 1 related proteinase . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|