| Interacting proteins: P00749 and P98164 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P00749 and P98164 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00749 and P98164 |
Pubmed |
SVM Score :1.0502929 |
| The activation of pro uPA to the active two chain uPA is accelerated with uPAR bound pro uPA and is achieved by plasmin and proteases of other classes like cathepsins G and L . uPAR bound uPA is susceptible to inhibition by its specific inhibitors ( PAI 1 , PAI 2 , and PN 1 ) . uPA PAI 1 and uPA PN 1 complexes , but not free uPA , are readily internalized and degraded through a mechanism that involves the multiligand receptors alpha 2 macroglobulin receptor / low density lipoprotein receptor associated protein ( alpha 2 MR ) and epithelial glycoprotein 330 ( gp 330 ) . 1.0502929^^^ |
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| Interacting proteins: P00749 and P98164 |
Pubmed |
SVM Score :0.68929223 |
| Using type 2 pneumocytes , endocytosis of a previously described gp 330 ligand , urokinase ( uPA ) complexed with plasminogen activator inhibitor 1 ( uPA : PAI 1 ) and two new ligands , PAI 1 and pro uPA , was demonstrated . 0.68929223^^^ In addition , gp 330 acts in concert with LRP in type 2 pneumocytes to mediate clearance of a variety of proteins involved in plasminogen activation , including uPA : PAI 1 complexes PAI 1 and pro uPA . ( ABSTRACT TRUNCATED AT 250 WORDS ) . 0.51540886^^^ |
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| Interacting proteins: P00749 and P98164 |
Pubmed |
SVM Score :1.739154 |
| In the present report , we describe that affinity purified gp 330 from rabbit renal cortex binds plasminogen activator inhibitor type 1 ( PAI 1 ) complexed with urokinase type plasminogen activator ( uPA ) . alpha 2M methylamine , which binds with high affinity to alpha 2MR / LRP , did not bind to gp 330 . 1.739154^^^ |
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| Interacting proteins: P00749 and P98164 |
Pubmed |
SVM Score :0.0 |
| The alpha 2MR and gp 330 mediated endocytosis of a ligand ( u PA / PAI 1 complex ) initially bound to another receptor ( u PAR ) is a novel kind of interaction between membrane receptors . ^^^ |
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