| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Activation of hepatocyte growth factor by urokinase type plasminogen activator is ionic strength dependent . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| In BAE cells , u PA activity and tube like structures in collagen gel were induced in the presence of HGF alone . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| The uPA expression in NUGC 3 cells was enhanced by adding conditioned media of fibroblast cells or HGF . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| HGF and EGF ) , and increased proteolytic enzyme activity ( e . g . uPA ) . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor increases urokinase type plasminogen activator ( u PA ) and u PA receptor expression in Madin Darby canine kidney epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA . ^^^ Herein we report that both urokinase type plasminogen activator and tissue type plasminogen activator can cleave single chain hepatocyte growth factor , generating two chain hepatocyte growth factor . ^^^ Also , urokinase type plasminogen activator was inactive against hepatocyte growth factor molecules with a mutated cleavage site . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| In view of the well recognized roles of u PA as one of the major initiators of the matrix proteolysis cascade and as an activator of plasminogen and hepatocyte growth factor ( HGF ) , we studied matrix degradation in liver shortly after partial hepatectomy . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor ( c met ) , autocrine motility factor receptor , and urokinase type plasminogen activator receptor . ^^^ BACKGROUND : Hepatocyte growth factor receptor ( c met ) , autocrine motility factor receptor ( AMFR ) , and urokinase type plasminogen activator receptor ( uPAR ) are known to play important roles in tumor cell migration , invasion , and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Western blot analyses and co immunoprecipitations were used to investigate the association of proteins involved in epidermal growth factor and hepatocyte growth factor activation and signaling : epidermal growth factor receptor , hepatocyte growth factor receptor ( MET ) , urokinase type plasminogen activator and its receptor , and a member of the signal transducer and activator of transcription family , STAT 3 . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Treatment of cells with hepatocyte growth factor , vascular endothelial growth factor , or transforming growth factor beta , all of which are known to be activated by a uPA dependent pathway , did not stimulate tyrosine phosphorylation of the 78 kDa protein . uPA induced an increase in [ ( 3 ) H ] thymidine incorporation into DNA , and cell numbers were unaffected in the presence of A 5 . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| These factors include hepatocyte growth factor ( HGF ) and its receptor c MET , and urokinase plasminogen activator ( uPA ) and its receptor uPAR , basic fibroblast growth factor ( bFGF ) , TGF alpha and TGF beta 1 . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| The demonstration of uPAR and uPA in primary granules is of particular interest , and may indicate that uPAR and uPA participate in the activation of latent hepatocyte growth factor of neutrophils . . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Urokinase type plasminogen activator ( uPA ) may serve this function , as it is an initiator of the matrix proteolysis cascade and induces hepatocyte growth factor expression . ^^^ Urokinase type plasminogen activator ( uPA ) may serve this function , as it is an initiator of the matrix proteolysis cascade and induces hepatocyte growth factor expression . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Urokinase type plasminogen activator ( uPA ) is implicated in the regulation of hepatic regeneration by activating hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Met protein positive papillary carcinoma cells may produce hepatocyte growth factor ( HGF ) and may activate HGF through the urokinase type plasminogen activator ( uPA ) bound to urokinase type plasminogen activator receptor ( uPA R ) . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Despite the fact that active uPAR / uPA complex is critical for hepatocyte growth factor ( HGF ) activation , no differences were detected between the IL 6 + / + and / livers in HGF activation as measured by receptor phosphorylation . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| This protease activates hepatocyte growth factor ( HGF ) and urokinase plasminogen activator ( uPA ) , two proteins thought to be involved in the growth and motility of cancer cells , particularly carcinomas , and in the vascularization of tumors . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| To determine whether these factors contribute to the distinct etiologies of fibrolamellar hepatocellular carcinoma and traditional hepatocellular carcinoma , we assayed hepatocyte growth factor , the hepatocyte growth factor receptor , and two hepatocyte growth factor activators , hepatocyte growth factor activator and urokinase type plasminogen activator , in hepatocellular carcinoma , fibrolamellar hepatocellular carcinoma , cirrhotic liver and normal liver . ^^^ Antibodies against urokinase type plasminogen activator , urokinase type plasminogen activator receptor , hepatocyte growth factor and hepatocyte growth factor receptor were used to analyze immunoperoxidase stained slides from the paraffin blocks . ^^^ Western blot analyses using antibodies against hepatocyte growth factor , hepatocyte growth factor receptor , phosphotyrosine , hepatocyte growth factor activator , urokinase type plasminogen activator receptor , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , fibrinogen and plasmin were performed on membrane enriched fractions from the frozen tissue , as was collagen zymography for matrix metalloproteinase 2 and matrix metalloproteinase 9 . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Effects of hepatocyte growth factor on urokinase type plasminogen activator ( uPA ) and uPA receptor in DU 145 prostate cancer cells . ^^^ Upstream , uPA and uPAR are regulated by various factors including hepatocyte growth factor ( HGF ) , which stimulates the uPA / uPAR proteolytic system and increases invasion of cancers . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Increased expression of the hepatocyte growth factor ( HGF ) receptor ( c met ) and urokinase type plasminogen ( uPA ) correlated with the development and metastasis of cancers . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine whether insulinlike growth factor 1 ( IGF 1 ) and hepatocyte growth factor ( HGF ) cooperate to induce migration and invasion of human colorectal carcinoma ( CRC ) cells and whether the effects of IGF 1 and / or HGF are mediated through activation of the urokinase plasminogen activator ( uPA ) / uPA receptor ( uPAR ) system , a central mediator of tumor cell migration and invasion . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To investigate the effect of combinational delivery of urokinase type plasminogen activator ( uPA ) and hepatocyte growth factor ( HGF ) genes on hepatic fibrosis . ^^^ Treatment of experimental hepatic fibrosis by combinational delivery of urokinase type plasminogen activator and hepatocyte growth factor genes . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| We investigated the hypotheses that ( a ) insulin like growth factor 1 ( IGF 1 ) and hepatocyte growth factor ( HGF ) mediated migration and invasion of human pancreatic carcinoma cells require uPA and uPAR function and ( b ) inhibition of uPAR inhibits tumor growth , retroperitoneal invasion , and hepatic metastasis of human pancreatic carcinomas in mice . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| The increase in hepatic activity of urokinase type plasminogen activator was also accompanied by more activation of the hepatocyte growth factor receptor c Met . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Recently , signaling events involving the urokinase type plasminogen activator receptor , which is a key regulator for the activation of hepatocyte growth factor ( HGF ) , have been implicated in modulating cortical neuron migration . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Up regulation of the hepatocyte growth factor ( HGF ) , its transmembrane tyrosine kinase receptor ( c Met ) , and urokinase type plasminogen activator ( uPA ) , is associated with the development and metastasis of various types of cancers . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| These complexes were probably formed by activation of urokinase type plasminogen activator ( u PA ) , and not tissue type plasminogen activator ( t PA ) , since SF levels of both u PA antigen and u PA plasminogen activator inhibitor ( PAI ) complexes were increased in 27 of the 42 patients . ^^^ In some patients , activation of factor 12 presumably also contributed to plasminogen activation in SF , since levels of factor XIIa C 1 inhibitor in SF were increased in 8 of the 42 patients and correlated , as did u PA PAI levels , with levels of PAP complexes . ^^^ Several of the parameters of fibrinolysis in SF , particularly u PA antigen and u PA PAI 1 complexes , were found to correlate with clinical and biochemical parameters . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| In contrast , u PA related plasminogen activation was strongly enhanced : urokinase type plasminogen activator ( u PA ) antigen ( 23 . 1 + / 12 . 4 ng / ml ) was more than four fold higher , single chain u PA ( scu PA ) ( 5 . 3 + / 1 . 9 ng / ml ) three fold higher than in plasma of the same patients or of healthy donors , and active two chain u PA ( tcu PA ) was detected in 14 of the 36 SF samples of RA patients . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| An autotumorolytic fraction ( ATF ) derived from sera of mice bearing spontaneous mammary adenocarcinoma has been purified by sequential chromatography on Sephacryl 200 SF , DEAE Sephacel , hydroxylapatite , and Sephacryl 200 SF . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| At the same time , internalization of u PA / u PAR complexes increased after incubation of chondrocytes with piroxicam or PAI 1 rich SF . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| In paired ( series 1 ) and unpaired SF ( series 2 ) we examined the occurrence of gelatinase B , prostromelysin 1 , and urokinase type plasminogen activator ( u PA ) . ^^^ The SF samples with the activated form of gelatinase B showed a significantly higher ability to induce permeability changes in cultured monolayers of human endothelial cells , had more myeloperoxidase activity secreted by infiltrated leukocytes and had higher u PA antigen concentrations , compared to SF samples without the activated form of gelatinase B . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Concentrations of PAI 2 correlated significantly with SF leukocyte count and cytidine deaminase ( CD ) activity and u PA concentrations correlated with CD activity . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Our results showed a low production of tissue type Plasminogen Activator ( t PA ) in both OA and RA SF , but relatively high levels of u PA , until confluence , both in OA and in RA . ^^^ Receptors for u PA were evident on both RA and OA SF . ^^^ Our data show that SF in vitro produce mainly u PA , the most important plasminogen activator involved in tissue modifications . ^^^ The demonstration of u PA receptors on the surface of OA and RA SF represents a step forward in the understanding of the possible role of fibrinolytic and tissue destructive proteinase cascade in joint inflammation . . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| During EGF or SF induced invasion , UM SCC 1 cells expressed urokinase type plasminogen activator ( uPA ) and uPA receptor as well as the matrix metalloproteinases ( MMPs ) , membrane type MMP 1 , collagenase 1 , stromelysin 1 , and gelatinase B . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| HGF / SF has to be cleaved in its heterodimeric form by the urokinase type plasminogen activator ( uPA ) to become active as a ligand for Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Maximum TGF responses , assessed from changes in proximal stop flow pressure ( P ( SF ) ) during orthograde loop of Henle ( LH ) perfusion of artificial tubular fluid ( ATF ) , were enhanced in SHR [ Wistar Kyoto rat ( WKY ) 8 . 8+ / 0 . 4 ( n = 30 nephrons ) vs . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Thrombin / antithrombin 3 complex ( TAT ) , soluble fibrin ( SF ) , total fibrinogen and fibrin degradation products ( TDP ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , urokinase type plasminogen activator ( uPA ) and uPA receptor ( uPAR ) were measured preoperatively , starting anesthesia , during surgery and postoperatively . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| METHODS : In SF obtained from RA patients and control subjects , uPA , uPAR and PAI 1 were measured by ELISA of cell lysates and culture medium and by RT PCR of mRNAs . uPA was also studied by zymography . ^^^ RESULTS : RA SF over express uPAR and PAI 1 and are more prone than the normal counterpart to spontaneous and uPA challenged invasion and proliferation , which are counteracted by antagonists of the fibrinolytic system . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| METHODS : We compared the antigenic values of urokinase type PA ( uPA ) , soluble uPA receptor ( suPAR ) , and PA inhibitor type 1 ( PAI 1 ) and the levels of matrix metalloproteinase 2 ( MMP 2 ) and MMP 9 in 63 synovial fluid ( SF ) samples from knee joints of 38 patients with gouty arthritis and 20 SF samples from knee joints of 20 patients with osteoarthritis ( OA ) . ^^^ RESULTS : The increases of uPA , suPAR , and PAI 1 antigenic values in SF were associated with increased levels of latent MMP 9 ( pro MMP 9 ) ( p < 0 . 001 , p < 0 . 001 , p < 0 . 001 , respectively ) in gouty arthritis , whereas a correlation was not observed between uPA , suPAR , and PAI 1 antigenic values and MMP 2 levels . ^^^ Increased uPA , suPAR , and PAI 1 antigenic values in gouty arthritis SF were also correlated to each other ( p < 0 . 001 , p < 0 . 001 , p < 0 . 001 ) . ^^^ In gouty arthritis SF , no significant relations were observed between uPA and suPAR antigenic values and leukocyte , neutrophil , or monocyte counts , while increased values of PAI 1 corresponded closely with increased leukocyte and neutrophil counts ( p = 0 . 005 , p = 0 . 004 ) . ^^^ Significantly higher values of the uPA , suPAR , and PAI 1 ( p < 0 . 001 , p < 0 . 001 , p = 0 . 012 ) appeared in SF of gouty arthritis than in SF from patients with OA . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| The increase in PAI 1 and TF mRNA was also seen when HepG 2 were incubated with HGF in the presence of cycloheximide , thereby indicating that de novo protein synthesis is not required to mediate the effect . u PA could be detected neither in unstimulated or HGF stimulated HepG 2 cells on the antigen level nor on the mRNA level . ^^^ One could speculate that HGF might modulate processes requiring matrix degradation by increasing the expression of the protease u PA in one cell type and by upregulating the expression of the serine protease inhibitor PAI 1 in a different cell type . ^^^ Because u PA has been shown to activate latent HGF to the active form , it could furthermore be speculated that by upregulating PAI 1 , which in turn could inhibit u PA , HGF might regulate its own activation . . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| HGF is produced in an inactive single chain form that can be cleaved in vitro to the active two chain form by tissue type and urokinase type plasminogen ( PLG ) activators ( tPA and uPA ) . ^^^ The uPA present in remnant liver homogenates from rats that underwent PHx is the primary agent that cleaves single chain HGF to its two chain form , because cleavage can be prevented when antibody against uPA is included in the liver homogenates . ^^^ These findings imply that both uPA and uPAR are involved in activating endogenous HGF in the regenerating livers of animals that underwent PHx . . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| We previously reported that the urokinase type plasminogen activator ( uPA ) activates pro HGF in vitro . ^^^ Activation involves the formation of a stable complex between pro HGF and uPA . ^^^ This complex was isolated from the in vitro reaction of pure uPA with recombinant pro HGF , as well as from the membrane of target cells , after sequential addition of uPA and pro HGF . ^^^ On the cell membrane , the uPA HGF complex was bound to the Met receptor . ^^^ The stoichiometry of the activation reaction suggests that the biological effects of HGF can be titrated in vivo by the level of uPA activity . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Infusion of EGF , HGF , uPA , or any combination thereof for up to 7 days resulted in increased numbers of [ 3H ] thymidine labeled ductal and periductal cells expanding into the liver acinus . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Analysis of cultures treated with HGF , epidermal growth factor , and transforming growth factor alpha ( TGF alpha ) alpha showed these growth factors increased the hepatocyte PA activity in parallel with the mRNA for u PA . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated the production of u PA in HLF cells . ^^^ These data suggest that HGF increase the invasion activity of human HCC cell lines by affecting the production of u PA or the chemotaxis for fibronectin . . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Zymography for proteolytic enzymes demonstrated high levels of type 4 collagenase and urokinase type plasminogen activator ( u PA ) activity in GB d 1 , GB h 3 and GB d 2 even in the absence of HGF . ^^^ In the presence of HGF , the 72 kDa type 4 collagenase ( MMP 2 ) activity of GB h 3 and u PA activities of GB d 1 , GB h 3 and GB d 2 were enhanced . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| In vitro , the HGF stimulated motogenesis of pancreas cancer cells involves the activation of the u PA / u PA receptor proteolytic system , suggesting its role in the invasive stages of tumor progression . . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| FGF 2 stimulated migration was blocked by antibodies against urokinase type plasminogen activator ( uPA ) or uPA receptor ( uPAR ) and by neutralizing anti HGF antibodies . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Likewise , HGF strongly enhanced urokinase type plasminogen activator activity and invasion of MMT cells through Matrigel : a 15 fold stimulation in the invasion of MMT cells was seen by HGF . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| In RT PCR experiments , tissue type PA ( tPA ) mRNA levels in both aged hGF and rGF were higher than in young cells , whereas plasminogen activator inhibitor 1 ( PAI 1 ) mRNA remained unchanged and urotype PA ( uPA ) mRNA was not detected . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Results obtained from in vitro experiments showed that urokinase type plasminogen activator ( uPA ) and tissue type plasminogen activator ( tPA ) can cleave single chain HGF . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| MDCK cells transformed by LMP 1 showed invasive growth to form branching tubules into collagen gel without HGF treatment . mRNA differential display and Northern hybridization identified plasminogen activator inhibitor 1 ( PAI 1 ) , urokinase type plasminogen activator ( uPA ) and ets 1 as genes upregulated during transformation by LMP 1 . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| In contrast , neither anti interleukin 8 ( IL 8 ) antibody nor anti hepatocyte growth factor ( HGF beta ) antibody affected uPA activity in the endothelial cells . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| These data show that a loss of balance concerning HGF , c met , and u PA mRNA expression occurs during hepatocarcinogenesis . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| In this study , effects of HGF / SF on urokinase type plasminogen activator ( uPA ) mediated proteolysis network were examined in c Met positive human glioma cell lines . ^^^ Treatment of the glioma cells with various concentrations of HGF / SF resulted in an enhanced secretion of uPA proteins accompanying increased transcription of uPA mRNA in a dose dependent fashion . ^^^ The levels of uPA receptor ( uPAR ) mRNAs were also elevated simultaneously upon HGF / SF stimulation , and the cell surface associated uPA activity was also elevated by the treatment . ^^^ Since concomitant expression of HGF and its receptor c Met are frequently observed in malignant gliomas , these results suggest that HGF / SF participates in invasive process of malignant glioma cells not only by its motility stimulating activity but also through enhanced degradation of the extracellular matrix induced by autocrine activation of uPA proteolysis network . . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| To explore the potential mechanisms involved in the beneficial effects of HGF , we performed in vitro studies with A 549 pulmonary epithelial cells and found that HGF enhanced cell surface plasmin generation , expression of u PA activity , and cell migration . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Caco 2 cells were found to express HGF receptor but not HGF and to secrete several proteases , namely matrix metalloproteinase 1 ( MMP 1 ) , MMP 2 , possibly MMP 9 and urokinase plasminogen activator ( uPA ) . ^^^ The involvement of proteases in the HGF induced invasion process was further investigated using either a synthetic general MMP inhibitor or neutralizing antibodies against MMPs or uPA . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| HGF further induced expression of the Ets 1 and urokinase type plasminogen activator ( uPA ) genes specifically in E1AF transfected cells . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| The novel serine protease HGF activator and urokinase type plasminogen activator ( u PA ) are responsible for the latter extracellular processing . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| We investigated the effect of HGF on the invasion of PC 3 and DU 145 prostate cancer cells through a reconstituted basement membrane ( Matrigel ) , the haptotactic migration to fibronectin substrate , the expression of protein and mRNA for matrix metalloproteinases ( MMP ) 1 and 9 , membrane type 1 MMP ( MT 1 MMP ) , urokinase type plasminogen activator ( u PA ) and its receptor ( uPAR ) . ^^^ Furthermore , HGF also increased the production of MMP 1 and 9 , MT 1 MMP , u PA and uPAR of these cells . ^^^ These results suggested that HGF increased the invasive potential of prostate cancer cells probably through enhancement of cell motility and the production of MMPs and u PA . . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Matrigel invasion was significantly enhanced in 3 of the cell lines and uPA levels were significantly increased in the SAOS 2 cells following HGF treatment . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| We also demonstrated that the HGF stimulated stromal cell invasion was due in part to the induction of urokinase type plasminogen activator , a member of the extracellular proteolysis system . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Moreover , functional analysis by Madine Darby canine kidney cell scattering and urokinase type plasminogen activator assays demonstrated that hFab Met 1 is not an agonist to HGF / Met signaling compared with a murine intact monoclonal antibody ( MAb ) Met 5 . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| Up regulations of hepatocytes growth factor ( HGF ) , its receptor ( c Met ) , and urokinase type plasminogen activator ( uPA ) are correlated with the development and metastasis of cancers . ^^^ In order to investigate roles of HGF / c Met signaling in tumor progression and metastasis in stomach cancers , we determined effects of a specific MEK 1 inhibitor ( PD 098059 ) and a p 38 kinase inhibitor ( SB 203580 ) on HGF mediated cell proliferation and uPA expression in stomach cancer cell lines ( NUGC 3 and MKN 28 ) . ^^^ Pre treatment with PD 098059 reduced HGF mediated cell proliferation and uPA secretion . ^^^ Stable expression of dominant negative MEK 1 in NUGC 3 cells showed a decrease in HGF mediated uPA secretion . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| HGF activator ( HGFA ) , matriptase , urokinase type plasminogen activator and hepsin are the main factors responsible for converting pro HGF into active HGF . ^^^ |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P00749 |
Pubmed |
SVM Score :0.0 |
| NA |
|