Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The effect of the activating substances for transferring the Hageman factor into its active form are represented with the role of the pre kallikrein ( Fletcher factor ) and of the highly molecular kininogen ( Fitzgerald factor ) being referred to . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The defect in each assay was reconstituted by afactor separable from Hageman factor or Fletcher factor . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Interactions among Hageman factor ( HG , Factor 12 ) , plasma thromboplastin antecedent ( PTA , Factor 11 ) , plasma prekallikrein ( PK , Fletcher factor ) and high molecular weight kininogen ( HMW K , Fitzgerald factor ) in blood coagulation . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Determination of Hageman factor ( HG , factor 12 ) and plasma prekallikrein ( Fletcher factor ) by radioimmunoassays . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Whale plasma had a greatly prolonged kaolin activated partial thromboplastin time and was deficient in Hageman factor ( factor 12 ) , Fletcher factor ( a plasma prekallikrein ) , and PTA ( factor 11 ) . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
This paper reports an asymptomatic coagulation defect responsible for an abnormality at the contact phase of blood coagulation in vitro , distinct from Hageman factor and Fletcher factor deficiencies . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Distinction from Hageman factor and `` Fletcher factor ' ' deficiency ; family study ; and problems of diagnosis . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Severe Fletcher factor ( plasma prekallikrein ) deficiency with partial deficiency of Hageman factor ( factor 12 ) : report of a case with observation on in vivo and in vitro leukocyte chemotaxis . ^^^ Surface induced fibrinolysis , amidolysis of alpha N benzoyl proline L phenylalanine L arginine p nitroanilide , and cold promoted enhancement of factor 7 activity , reactions requiring the presence in the plasma of fletcher factor ( prekallikrein ) , in addition to Hageman factor and Fitzgerald factor ( high molecular weight kininogen ) , were also defective . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
We found that the clotpromoting activity and antigenic properties of Hageman factor were present in lower levels in the plasma of a small group of Oriental subjects than in that of American whites , whereas the levels of plasma prekallikrein ( Fletcher factor ) , high molecular weight kininogen ( Fitzgerald factor ) , and plasma thromboplastin antecedent ( factor 11 ) in plasma samples from Oriental subjects did not significantly differ from those from normal white subjects . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
It is the absence of this feedback in Fletcher factor deficient plasma that accounts for the diminished rate of activation of Hageman factor and therefore a diminished rate of activation of the coagulation and fibrinolytic pathways . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
To identify this enzyme we first tested the ability of Hageman factor fragments , plasma kallikrein ( EC 3 . 4 . 21 . 8 ) , and plasmin ( EC 3 . 4 . 21 . 7 ) to activate prorenin in acid treated plasma . ^^^ All three enzymes initiated prorenin activation ; 50 % activation was achieved with Hageman factor fragments at 1 microgram / ml , plasma kallikrein at 2 4 microgram / ml , or plasmin at 5 10 microgram / ml . ^^^ We then found that , although plasma kallikrein could activate prorenin in plasma deficient in either Hageman factor or prekallikrein , Hageman factor fragments were unable to activate prorenin in prekallikrein deficient plasma . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Plasma kallikrein was assayed by means of its esterase activity on a synthetic arginine ester substrate , N alpha tosyl L arginine methyl ester ( TAMe ) , after activation of Hageman factor by kaolin . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
At physiological concentration ( 50 microgram / ml ) , alpha 2PI inhibited the clot promoting and prekallikrein activating activity of Hageman factor fragments , the amidolytic , kininogenase , and clot promoting activities of plasma kallikrein , and the clot promoting properties of activated plasma thromboplastin antecedent ( PTA , Factor XIa ) and thrombin . alpha 2PI had minimal inhibitory effect on surface bound activated PTA and activated Stuart factor ( Factor Xa ) . alpha 2PI did not inhibit the activity of activated Christmas factor ( Factor IXa ) or urinary kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Recently , Gjnnaess reported experiments suggesting that plasma kallikrein was an intermediate between Hageman factor and factor 7 . ^^^ These results further support the idea that the enhancement of factor 7 activity by surface contact is via Hageman factor and plasma kallikrein , suggesting a possible link between the intrinsic and extrinsic pathway of blood clotting . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
We herein report that , like plasma kallikrein , preparations rich in this basophil protease also activate human Hageman Factor by proteolytic cleavage of the zymogen molecule into light and heavy chains . ^^^ These fragments of 28 , 000 and 52 , 000 daltons are similar in size to those produced during activation of Hageman Factor by plasma kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
However , despite this remarkable antikallikrein effect and the known importance of plasma kallikrein in the activation of Hageman factor ( factor 12 ) , the compounds had only little influence on the early stages of blood coagulation . . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Activation mechanism of human Hageman factor plasma kallikrein kinin system by Vibrio vulnificus metalloprotease . ^^^ The VVP inoculated into a guinea pig is known to generate bradykinin through activation of the Hageman factor plasma kallikrein kinin system . ^^^ VVP was shown to possess the ability to activate the human system through the same mechanism as that clarified in the guinea pig system , namely , VVP converted both human zymogens ( Hageman factor and plasma prekallikrein ) to active enzymes ( activated Hageman factor and plasma kallikrein ) , and the then generated kallikrein liberated bradykinin from high molecular weight kininogen . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Furthermore , in vitro conversion of plasma prekallikrein to kallikrein by the C . albicans proteinase was observed , and the reaction was inhibited by corn trypsin inhibitor , an inhibitor of activated Hageman factor , and soybean trypsin inhibitor , a well known inhibitor of plasma kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Contact activation was demonstrated by the presence of plasma kallikrein ( KK ) activity and activated Hageman factor ( FXIIa ) and / or KK in complex with C 1 inhibitor ( C1inh ) , detected by chromogenic peptide substrates or radioimmunoassays , using monoclonal antibodies directed to neodeterminants exposed on complexed C1inh , respectively . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Trypsin ( Try ) , plasma kallikrein ( KK ) and plasmin activities together with coagulation factor 12 ( F 12 , Hageman factor ) , high molecular weight kininogen ( HMWK ) , plasma prekallikrein ( PKK ) , alpha 2 macroglobulin ( alpha 2 M ) , C 1 inhibitor ( C1Inh ) , and functional plasma kallikrein inhibition ( KKI ) values were studied in peritoneal fluid and lavage taps of 9 patients with severe acute pancreatitis treated with peritoneal lavage . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
In the in vivo study the enhancement of vascular permeability in guinea pig skin and its sensitivity to inhibitors of activated Hageman factor , plasma kallikrein , or a kininase were examined . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Furthermore , the permeability activity of the protease , but not the amidolytic activity , was inhibited by soybean trypsin inhibitor , a well known inhibitor of plasma kallikrein , as well as by corn trypsin inhibitor , the best inhibitor of activated Hageman factor . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The phenomenon was inhibited by soybean trypsin inhibitor , a well known inhibitor of plasma kallikrein , and also by corn trypsin inhibitor , which is the best inhibitor of the activated Hageman factor . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The inhibitory effects of 6 amidino 2 naphthyl 4 guanidinobenzoate 10 dimethanesulfonate ( FUT 175 ) on the human Hageman factor fragment ( HFf ) , factor Xa , thrombin , plasma kallikrein , and plasmin were studied . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Interaction of trypsin , beta factor XIIa , and plasma kallikrein with a trypsin inhibitor isolated from barley seeds : a comparison with the corn inhibitor of activated Hageman factor . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The chamber fluids were sampled over a 6 hr period for histamine and activated Hageman factor and plasma kallikrein which were complexed to C 1 inhibitor . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
C 1 ( ) inhibitor ( C 1 ( ) INH ) proteins from normal persons and members of eight different kindred with dysfunctional C 1 ( ) INH proteins associated with hereditary angioneurotic edema ( HANE ) were compared with respect to their inhibitory activity against purified preparations of C1s , plasma kallikrein , activated forms of Hageman factor , and plasmin . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Endotoxin induced kinin ( bradykinin ) formation : activation of Hageman factor and plasma kallikrein in human plasma . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Influence of betamethasone on Hageman factor activation of human plasma kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Glucocorticoids and Hageman factor activation of human plasma kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Plasma kallikrein and Hageman factor in Gram negative bacteremia . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Activation of bovine factor 12 ( Hageman factor ) by plasma kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Substances biologically similar to plasma kallikrein ( KK ) , a Hageman factor activator , have been shown to be released by basophils in the course of an IgE dependent reaction . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Various flower bulbs and vegetable and legume seeds were tested for inhibitors of polymorphonuclear leukocyte elastase , pancreatic elastase , cathepsin G , cathepsin B , trypsin , alpha chymotrypsin , Hageman factor fragments , plasma kallikrein , and plasmin . ^^^ Seeds of some members in the Cruciferae family , such as radish and broccoli , were found to contain one or more 2 , 500 4 , 000 dalton inhibitors which inhibited cathepsin G , trypsin , Hageman factor fragments , and plasmin , but not plasma kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The 56K protease , which requires zinc ion for activity , was found to possess plasma kallikrein like properties in vitro as judged by ( 1 ) preferential amidolysis of carbobenzoxy Phe Arg 4 methylcoumaryl 7 amide and Pro Phe Arg 4 methylcoumaryl 7 amide , which are known substrates for plasma kallikrein ; ( 2 ) release of kinin from high molecular weight kininogen ; and ( 3 ) prompt activation of Hageman factor followed by generation of kallikrein from plasma prekallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Assay for Hageman factor ( factor 12 ) in human plasma by means of chromogenic substrate for plasma kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Plasma kallikrein activated to Hageman factor released kinin rapidly from bovine high molecular weight ( HMW ) kininogen . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The 28 , 000 dalton active form of Hageman factor ( beta HFa ) was prepared from guinea pig Hageman factor by treatment with plasma kallikrein . beta HFa caused an increase in vascular permeability when injected into guinea pig skin at concentrations as low as 3 10 10 ( 10 ) M ( 0 . 8 ng ) . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Probably this is the reason why the beta form activated Hageman factor ( the proteinase moiety ) is not liberated in the activation of the bovine molecule with trypsin or plasma kallikrein . . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
These pulmonary lesions were prevented when the infected animals were treated with H D Pro Phe Arg chloromethylketone , an inhibitor of coagulation factor 12 and plasma kallikrein , suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease . . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
In the activation of the contact system , blood coagulation factor 12 and plasma kallikrein play central roles , and a specific inhibitor of these serine proteinases inhibited the release of bradykinin by S . aureus in human plasma . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
This short lived peptide hormone is liberated from its large precursor protein high molecular weight kininogen ( HK ) through the contact system cascade involving coagulation factor 12 and plasma kallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Blood coagulation factor 12 ( FXII , Hageman factor ) is a plasma serine protease which is autoactivated following contact with negatively charged surfaces in a reaction involving plasma kallikrein and high molecular weight kininogen ( contact phase activation ) . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Interactions among Hageman factor , plasma prekallikrein , high molecular weight kininogen , and plasma thromboplastin antecedent . ^^^ In the absence of plasma prekallikrein , maximal activation of plasma thromboplastin antecedent was slightly delayed in plasma , a delay not observed with similarly treated purified Hageman factor . ^^^ Thus , high molecular weight kininogen was needed for expression of Hageman factor ' s clot promoting properties and plasma prekallikrein played a minor role in the interaction of ellagic acid treated Hageman factor and plasma thromboplastin antecedent . . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Human plasma prekallikrein : mechanism of activation by Hageman factor and participation in hageman factor dependent fibrinolysis . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The mean titers of Hageman factor , plasma prekallikrein and serum hemolytic complement activity were decreased at the time of admission and 2 hours after treatment , and rose to normal values during convalescence . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The author describes the method of assessment of the C 1 inhibitor , the principle being activation of plasma prekallikrein by Hageman factor fragment ( HFf ) to the active enzyme kallikrein which splits the specific chromogenic substrate NO Pro Phe Arg pNA . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Similarly , only small amounts of Hageman factor ( factor 12 ) and antihemophilic factor ( factor 8 ) were detected , and none of plasma prekallikrein , high molecular weight kininogen , and Christmas factor ( factor 9 ) . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The incubation of rat or human plasma with degranulated mast cell ( DMC ) suspension did not cause the activation of plasma prekallikrein , but did cause a loss in the activity of coagulation factor 12 , as ascertained by the lack of activation of prekallikrein in either the DMC treated plasma by glass powder or in the incubation of DMC treated human plasma with factor 12 deficient plasma activated by kaolin . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Immunoblotting studies of coagulation factor 12 , plasma prekallikrein , and high molecular weight kininogen . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Immunoblotting of blood coagulation Factor 12 and plasma prekallikrein in whole plasma was performed using radiolabeled antigen for detection . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Determination of plasma prekallikrein using beta XIIa ( Hageman factor fragment ) ] . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Within the first day after trauma significantly reduced values were found for plasma prekallikrein ( PKK ) , Hageman factor ( HF ) and Antithrombin 3 ( AT 3 ) . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Plasma prekallikrein : quantitative determination by direct activation with Hageman factor fragment ( beta XIIa ) . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Studies on Hageman factor , plasma prekallikrein , kallikrein `` like ' ' activity and kallikrein inhibition in plasma samples from normal subjects and clinical material . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Enzymatic properties of human Hageman factor fragment with plasma prekallikrein and synthetic substrates . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Its dependence on Hageman factor , plasma prekallikrein , and high molecular weight kininogen . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Studies on some coagulation factors ( Hageman factor , plasma prekallikrein , and high molecular weight kininogen ) in the normal newborn . ^^^ The present study confirms the presence of decreased titers of Hageman factor ( HF , factor 12 ) , plasma prekallikrein , and high molecular weight kininogen during the neonatal period , as demonstrated in clotting assays ; the degree of these relative deficiencies is usually such that only the low titer of HF appears to contribute significantly to the abnormally long PTT . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Bradykinin ( BK ) is released directly from kininogens or through activation of either Hageman factor or subsequent plasma prekallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
The initial step in activation of the plasma kinin system is activation of Hageman factor ( coagulation factor 12 ) and / or plasma prekallikrein . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Determination of serum complement factors , C 1 inhibitor protein , C 1 inhibitor function , coagulation factor 12 , plasma prekallikrein , high molecular weight kininogen , and selected DNA sequences were performed in affected members by using standard assays . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
A procedure of isolation of human blood plasma prekallikrein , coagulation factor 12 and active fragment beta XIIa has been developed . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
Plasma prekallikrein failed to induce regression without coactivators such as high molecular weight kininogen ( HMWK ) or coagulation Factor 12 . ^^^
Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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Interacting proteins: P03952 and P00748 Pubmed SVM Score :0.0
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