| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.66184319 |
| The interaction of C 1 Inh with dimeric C1r in the presence of EDTA resulted into two bimolecular complexes accounting for a disruption of C1r . 0.66184319^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| However , the peptide esterase inhibitors Trasylol , hirudin , leupeptin , and C 1 esterase inhibitor had no effect on the esterase activity of C1r . . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| The role of C 1 esterase inhibitor in the activation of C1r , a subcomponent of the first component of complement from human plasma . ^^^ On thecolumn , the C 1 esterase inhibitor activity was found to coincide with Clr but not C1s ( another subcomponent of the first component ) C1r was isolated from the euglobulin fraction of human serum by DEAE cellulose column chromatograph . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| While single individuals with C1r , C 2 and C1Inh deficiency were found to have low anti PCP antibody levels , no other group of complement deficiency had significantly reduced anti PCP antibody levels compared with 100 controls . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| At the time of acute edema the complement profile was typical : virtual absence of C 1 INH function was associated with diminished concentrations of the components of the classical pathway of complement ( C1q , C1r , C1s , C 2 , C 4 ) and reduced complement hemolytic activity ( CH 50 ) . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| C 1 inhibitor ( C1inh ) , a member of the serine protease inhibitor gene superfamily , is a glycosylated plasma protein inhibiting the proteolytic activities of C1r and C1s and involved in the regulation of coagulation , fibrinolysis and kinin releasing systems . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| To evaluate the involvement of the complement system in atherogenesis , we investigated the effect of camostat mesilate ( CM ) , C1r , and C 1 esterase inhibitor on cholesterol induced atherosclerosis in rabbits . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| During activation , the first component of complement C1q ( C1r C1s ) 2 is dissociated in conjunction with the formation of complexes containing C 1 esterase inhibitor ( C 1 INH ) . ^^^ Trimer complexes , with zymogen C1s associated with a firm C 1 INH C1r complex ( C 1 INH C1r C1s ) can be distinguished from tetramer complexes C 1 INH C1r C1s C 1 INH ) in which C 1 INH is firmly bound to both proteases . ^^^ In the present study a two stage electroimmunoassay was developed for the specific measurement of C 1 INH C1r C1s . ^^^ In the second step , C1s contained in C 1 INH C1r C1s was dissociated in the presence of EDTA and was measured by immunoprecipitation with anti C1s . ^^^ C 1 INH C1r C1s were consistently found in normal sera . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| C 1 INH inactivation of C1r and C1s within activated macromolecular C 1 results in dissociation of C 1 with release of complexes consisting of two molecules of C 1 INH and one molecule each of C1r and C1s . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| C 1 INH is the only plasma protease inhibitor of activated C1r and C1s , the serine protease subcomponents of the first complement component . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| Circulating C1INH C1r C1s complexes were evidenced by reduced ratios of functional to antigenic C1INH and antigenic C1r to C1s . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| The human complement components C1r , C1s , C 4 , C 3 , factor B , and / or activated C1INH were functionally blocked in normal human serum ( NHS ) and EGTA or EDTA treated NHS by polyclonal monospecific Fab ' fragments to the individual components . ^^^ Blocking subcomponent C1r , completely inhibited spontaneous activation of the complement components , indicating that the control of C1r hydrolysis is the essential role of activated C1INH as a regulator of C 1 activation in NHS . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| When macromolecular C 1 was offered in the presence of C 1 INH , C1r cleavage was detected ; however , the presence of C1s was a critical factor for C1r activation , because it was required on CL vesicles , but not on immune complexes . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| CL vesicles which activate C 1 in the presence of C 1 inhibitor ( C 1 INH ) were found to bind C1s in the absence of C1r , and to induce a specific C1r independent cleavage of C1q bound C1s . ^^^ Therefore , several known natural nonimmune activators were analyzed by comparing their ability to activate C 1 in the presence of C 1 INH and to mediate a C1r independent cleavage of C1s . ^^^ DNA , known to activate C 1 only in the absence of C 1 INH , does not induce C1s cleavage in the absence of C1r . ^^^ In the case of `` weak ' ' activators , such as E . coli smooth strains , DNA , or HHM , no C1s binding to activator bound C1q was detected , and C1r independent C1s cleavage and C 1 activation in the presence of C 1 INH were not observed . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| We have studied the effects of polyclonal monospecific Fab ' preparations against C1r , C1s , C1INH , C 4 , C4bp , and fragment Bb of factor B on complement activation in NHS and HAES . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| C 1 Inh , which probably binds to C1r through the open end of the C 1 cone , is too long asymmetric to be included within the cage . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| DFP ( 5mM ) and C 1 Inh at a C 1 Inh / C1r ratio of 1 : 1 were effective on the solely intermolecular activation , leading to partial inhibition of the autoactivation from proenzymic C1r : C1r formed during the activation was titrated by the inhibitors . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| Kinetics of the reaction between human C 1 esterase inhibitor and C1r or C1s . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| Complement components C1q , C1r / C1s , and C1INH in rheumatoid arthritis . ^^^ To analyze the synovial site and the cell types expressing C1q , C1r / C1s , and C 1 esterase inhibitor ( C1INH ) and to characterize newly synthesized C1q in patients with rheumatoid arthritis ( RA ) . ^^^ Tissue and primary cell cultures of synovium from RA patients were analyzed for C1q , C1r / C1s , and C1INH by Northern blotting , in situ hybridization , and pulse chase experiments for C1q . ^^^ The de novo synthesis of C1q , C1r / C1s , and C1INH in synovium and primary cell cultures was proven by Northern blot and by antigenic and functional analysis . ^^^ In in situ hybridization experiments , the synovial lining cell layer was identified as the site of C1q , C1r , and C1INH expression . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| In comparison to the baseline , the mean values for C1q , C1r , C 2 , C 5 , C 6 , C 7 , C 8 , C 9 , FB , C1INH , C4BP , FH and FI exhibited a 3 5 fold increase , C 3 , total C 4 , albumin and the alpha 1 globulin fraction a 6 9 fold increase , and C1s , C4A , C4B , FB and alpha 2 , beta and gamma globulins a 10 20 fold increase . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| In this paper we demonstrate the synthesis of the components of the classical complement pathway , namely C1q , C1r , C1s , C 1 Inh , C 2 , C 4 , and C 5 , by human glioma cell lines ( U118MG , T 193 , and T98G ) . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| C 1 inh antigenic levels were normal in all patients ; however , the function of the C 1 inh tested against C1s and C1r was variable and outside the normal functional range in seven of the eight patients . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| Of the 22 complement proteins examined , 13 bound heparin ( C1q , C 2 , C 4 , C4bp , C1INH , B , D , H , P , C 6 , C 8 , C 9 , and vitronectin ) while 9 did not bind heparin ( C1r , C1s , C 3 , Factor 1 , C 5 , C 7 , C3b , Ba and Bb ) . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemically , C 1 esterase inhibitor ( C 1 Inh ) and the C 1 subcomponents C1s and C1r can not , or only occasionally , be detected in plaques or in astrocytes . ^^^ The present finding that C1q , C1s and C 1 Inh mRNA are present in both AD and control brains suggests that the variable immunohistochemical staining results for C1r , C1s and C 1 Inh are due to a rapid consumption , and that the inability to detect C1s , C1r or C 1 Inh is probably due to the dissociation of C1s C 1 Inh and C1r C 1 Inh complexes from the activator bound C1q into the fluid phase . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| A dysfunctional C 1 inhibitor ( C 1 INH ) from a family in whom the propositus presented with systemic lupus erythematosus but without angioedema previously was shown to have diminished inhibitory activity toward isolated C1r and C1s , and intact C 1 . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| Measuring C1r is a effective way to assess C 1 INH function and monitor therapy . . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| The ratio of AD to control mRNAs in these four areas was 1 . 17 for C 1 inh and 1 . 12 for CD 59 , compared to 3 . 06 for C1r , 2 . 67 for C1s , 2 . 35 for C 5 , 2 . 56 for C 6 , 2 . 42 for C 7 , 5 . 08 for C 8 and 16 . 3 for C 9 . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| Electroimmunoassays showed that lipoteichoic acid separately , yielded detectable amounts of free C1r2s2 subunits ; it also generated significantly more trimer complexes between C1r , C1s and C 1 inhibitor ( C1INH ) than did the other two activators . ^^^ Lipoteichoic acid was , however , a comparatively weak inducer of tetramer C1INH C1r C1s C1INH complexes . ^^^ Analysis through Western blotting showed that all activators accelerated consumption of C1r , induced complex formations between C1INH and C1s and produced cleavage products of C 2 . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| C 1 esterase inhibitor is a M ( r ) approximately 105 , 000 glycoprotein and the sole regulation of the activities of C1r and C1s . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| Thus , C 1 Inh production is refractory to stimulation by plaque associated cytokines , whereas these cytokines do stimulate C1r , C1s , and also C 4 and C 3 secretion by astrocytes and neuronal cells in culture . ^^^ The ability of C1q to reassociate with newly formed C1r and C1s upon activation of C 1 and subsequent inactivation by C 1 Inh , may enable ongoing complement activation at sites of amyloid deposition , especially when C 1 Inh is consumed and not replaced . . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| C 1 inhibitor ( C 1 INH ) , an inhibitor for C1r and C1s , formed equimolar complexes with MASP 1 and MASP 2 and inhibited their proteolytic activities . . ^^^ |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00736 and P05155 |
Pubmed |
SVM Score :0.0 |
| NA |
|