| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| NO and O 2 . with aconitase and even the enzymatic dismutation of O 2 . by superoxide dismutase . ^^^ |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| As expected , in cells overexpressing CuZn SOD , both total and cytosolic aconitase activities have increased . ^^^ |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| In SOD 2 Ad , high glucose failed to suppress aconitase activity or increase collagen accumulation . ^^^ |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| This fraction of inactive , but activatable , aconitase was increased by augmenting O 2 production with paraquat , decreased by elevation of superoxide dismutase , and increased by inhibiting reactivation with alpha , alpha ' dipyridyl . ^^^ |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Mutants of Escherichia coli lacking superoxide dismutase ( SOD ) activity were used to explore the sensitivity of aconitase toward O 2 and O 2 . ^^^ |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Overproduction of mitochondrial Mn superoxide dismutase protected aconitase from inactivation by PMS or inhibitors of ubiquinol cytochrome c oxidoreductase , but not from normobaric hyperoxia . ^^^ Extracellular O 2 . generated with xanthine oxidase did not affect aconitase activity nor did exogenous superoxide dismutase decrease aconitase inactivation by PMS . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Aconitase activity was approximately 25 % lower in GSH deficient cells growing on either glucose or succinate , and was lower still in strains producing less superoxide dismutase . ^^^ |
|
| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Elevated superoxide dismutase activity did not affect the aerobic inactivation of aconitase by NO . , thus indicating a limited role of the NO . and superoxide derived species peroxynitrite . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The water soluble antioxidant N acetylcysteine only partially inhibits the photoinduced inactivation of the cytoplasmic aconitase function , whereas the lipophilic vitamin E , the iron chelator , desferrioxamine and the superoxide dismutase inhibitor , diethyldithiocarbamate do not protect at all . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Thus peroxynitrite inhibits or damages mitochondrial complexes 1 , 2 , 4 and 5 , aconitase , creatine kinase , the mitochondrial membrane , mitochondrial DNA , superoxide dismutase , and induces mitochondrial swelling , depolarisation , calcium release and permeability transition . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| As with other yeast genes implicated in Fe / S protein assembly , deletion of either ISU 1 or ISU 2 results in increased accumulation of iron within the mitochondria , loss of activity of the [ 4Fe 4S ] aconitase enzyme , and suppression of oxidative damage in cells lacking cytosolic copper / zinc superoxide dismutase . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| To determine if mitochondrial O 2 ( ) production was an important determinant in neuronal death resulting from OGD , metalloporphyrins with varying superoxide dismutase ( SOD ) activity were tested for their ability to protect against mitochondrial aconitase inactivation and cell death . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Some of these measures provided evidence for an increase in oxidative stress in the mutant mice ( aconitase activity , oxidized glutathione , and lipid peroxides ) , but others did not ( superoxide dismutase , protein thiol content , carbonyl protein content , total glutathione , glutathione peroxidase , catalase , and thiobarbituric reducing substances ) . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Third , iron release and IRP 1 activation were observed in lysates from control or iron loaded macrophages , containing increasing levels of Fe S clusters , but not in lysates from iron starved macrophages , in which aconitase had already undergone cluster disassembly and switched to IRP 1 . * NO was less efficient than ONOO ( ) in attacking the Fe S cluster of cytoplasmic aconitase ; in fact , SIN 1 dependent iron release and IRP 1 activation were diminished by superoxide dismutase , which scavenged O ( 2 ) ( * ) before it reacted with * NO to form ONOO ( ) . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| In cultured VSMCs , phenylephrine caused time and dose dependent ROS generation ( aconitase activity ) , had similar efficacy to thrombin ( 1 U / mL ) , and was eliminated by the superoxide dismutase ( SOD ) mimetic Mn ( 3 ) tetrakis ( 4 benzoic acid ) porphyrin chloride ( 200 micromol / L ) and Tiron . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that a subset of mice with partial deficiency of the mitochondrial superoxide dismutase ( Sod 2 ( / + ) ) show increased incidence of spontaneous and handling induced seizures that correlates with chronic mitochondrial oxidative stress ( increased aconitase inactivation and 8 hydroxy 2 ' deoxyguanosine formation in mitochondria ) and diminished mitochondrial oxygen utilization . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| To investigate whether LA and DHLA remove copper or iron from the active site of enzymes , Cu , Zn superoxide dismutase and the iron containing enzyme aconitase were used . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| In this article , we discuss a hypothesis to explain the preferential synthesis of the superoxide sensitive form of aconitase in mitochondria and the phenotype observed in manganese superoxide dismutase mutant mice , which show a gross over accumulation of stored fat in liver . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Measurements of ( mitochondrial matrix ) aconitase inhibition , performed in the presence of exogenous superoxide dismutase and catalase , confirmed this hypothesis . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Here , we show that in superoxide dismutase 1 ( SOD 1 ) knock out mice , lacking Cu , Zn SOD , an enzyme that acts to reduce the concentration of O2 * mainly in cytosol , not only is aconitase activity of IRP 1 inhibited but the level of IRP 1 is also strongly decreased . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The topology of superoxide generation by sn glycerol 3 phosphate dehydrogenase and complex 3 in intact Drosophila mitochondria was studied using aconitase inactivation to measure superoxide production in the matrix , and hydrogen peroxide formation in the presence of superoxide dismutase to measure superoxide production from both sides of the membrane . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Whereas the manganese superoxide dismutase ( MnSOD ) activity was increased in the heat shocked cells , the mitochondrial aconitase activity was reduced . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Serum was assayed for protein , albumin , total antioxidant status ( TAS ) , manganese superoxide dismutase ( Mn SOD ) , aconitase , glutathione peroxidase ( GPx ) , heat shock protein 70 , isoprostane , and reactive oxygen species , using electron spin resonance and chemiluminescence . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The inactivation of aconitase was iron dependent , and prevented by TEMPOL , a scavenger of reactive oxygen species and superoxide dismutase , suggesting that the hinokitiol / iron mediated generation of superoxide anion is responsible for the inactivation of aconitase . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Preconditioning induced oxidative stress was assessed using aconitase activity and manganese superoxide dismutase ( MnSOD ) transcript levels . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the refed rats show , in both SS and IMF muscle mitochondria , a lower aconitase activity ( whose inactivation is an index of increased reactive oxygen species [ ROS ] ) , associated with higher superoxide dismutase activity and increased proton leak . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Inactivation of the TCA cycle enzyme , aconitase , was used as a marker of intracellular O 2 levels , and a porphyrin SOD mimetic was used to scavenge O 2 . ^^^ The selective , reversible , and SOD sensitive inactivation of aconitase by known O 2 generators was used to validate aconitase activity as a marker of O 2 generation . ^^^ The SOD mimetic , but not its less active congener , attenuated both aconitase inactivation and cell death produced by NMDA , KA , and PQ2+ . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The functions controlled by this system consist of a wide variety of enzymes such as manganese containing SOD ( Mn SOD ) ; glucose 6 phosphate dehydrogenase ( G6PD ) , the DNA repair enzyme endonuclease 4 , fumarase C , NADPH : ferredoxin oxidoreductase , and aconitase . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Sod 2 / mice on a CD 1 ( outbred ) genetic background die within the first 10 days of life ( mean , 5 . 4 days ) with a complex phenotype that includes dilated cardiomyopathy , accumulation of lipid in liver and skeletal muscle , metabolic acidosis and ketosis , and a severe reduction in succinate dehydrogenase ( complex 2 ) and aconitase ( a TCA cycle enzyme ) activities in the heart and , to a lesser extent , in other organs . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| In vitro infection of mesangial cells ( MC ) with a recombinant adenovirus encoding human SOD 1 increased SOD 1 activity threefold over control cells and prevented the reduction of aconitase activity , an index of cellular superoxide , and the increase in collagen synthesis that otherwise occurred in control MC in response to culture with 300 or 500 mg / dl glucose . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The resulting peptide mass spectrum was compared with the Mascot and Protein Prospector databases and resulted in the specific identification of heart mitochondrial proteins , specifically Mn superoxide dismutase ( SOD ) , aconitase ( ACN ) , and malate dehydrogenase ( MDH ) . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Eleven loci Gpi , Hk 4 , Odh , Est 2 , Pgm , Sod 1 , Gpd , Had , Aco 2 , Idh 2 , and Est 5 were assigned to LG 2 and spanned approximately 60 map units . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The overexpression of Sods mitochondrial Sod 2 and cytosolic CuZnSod ( Sod 1 ) delays the age dependent reversible inactivation of mitochondrial aconitase , a superoxide sensitive enzyme , and extends survival by 30 % . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Conversely , mitochondrial aconitase activity is relatively insensitive to loss of Sod 1 function , but drops dramatically if Sod 2 activity is impaired . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The activity of a second matrix protein , the tricarboxylic acid cycle enzyme aconitase , was similarly lowered in sod 1 Delta mutants . ^^^ |
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| Interacting proteins: P00441 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The 11 genes and their chromosomal positions are as follows : ALVEB 5 , 1p26 24 ; ACO 2 , 1p16 14 ; HSP 108 , 1p14 13 ; CD 4 , 1q11 ; HSD3B ; 1q11 ; SOD 1 , 1q14 21 ; LAMP 1 , 1q24 31 ; P2Y5 , 1q35 36 ; EN 2 , 2p31 24 ; NPY , 2p14 13 and CA 2 , 2q31 32 . ^^^ |
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