| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Yeast mutants null for superoxide dismutase were partially rescued by expression of Bcl 2 . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Human Bcl 2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild type yeast . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Mitochondrial antioxidants ( Mn superoxide dismutase and Bcl 2 ) were up regulated . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Modified expression of Bcl 2 and SOD 1 proteins in lymphocytes from sporadic ALS patients . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| For example , bax , which can exist as a homodimer , is also able to form a heterodimer with bcl 2 . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Simultaneously , FUS downregulated cellular survival components ( e . g . , bcl 2 , SOD ) . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In addition , RA reversed the downregulations of GSH , SOD and Bcl 2 by ADR . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| This was additive to the effect of GM CSF ( 50 U / ml ) , not associated with induction of bcl 2 expression , and was not mimicked by methionine ( 5 mM ) , superoxide dismutase ( 200 micrograms / ml ) or Trolox ( 10 mM ) but was mimicked by catalase ( 250 micrograms / ml ) . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We found that expression of bcl 2 in superoxide dismutase deficient ( SOD ) Escherichia coli resulted in increased transcription of the KatG catalase peroxidase , a 13 fold increase in KatG activity and a 100 fold increase in resistance to hydrogen peroxide . ^^^ In support of a pro oxidant mechanism in eukaryotic cells , we found a 73 % increase in superoxide dismutase activity in a murine B cell line overexpressing Bcl 2 . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The c Myc and TNF induced apoptosis was inhibited by ectopic expression of the Bcl 2 oncoprotein and by the free oxygen radical scavenging enzyme Mn superoxide dismutase . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Differential sensitivity of normal and Ha ras transformed C3H mouse embryo fibroblasts to tumor necrosis factor : induction of bcl 2 , c myc , and manganese superoxide dismutase in resistant cells . ^^^ However , TNF resistant cells , but not sensitive cells , overexpressed bcl 2 , c myc , and manganese superoxide dismutase ( MnSOD ) mRNA following exposure to TNF . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| RESULTS : It has been shown that an increased level of CuZn superoxide dismutase and antiapoptotic protein Bcl 2 in the brains of transgenic mice protects neurons from ischemic / reperfusion injury , whereas a deficiency in CuZn superoxide dismutase or mitochondrial Mn superoxide dismutase exacerbates ischemic brain damage . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| GT 1 7 cells overexpressing bcl 2 had the same level of glutathione peroxidase , catalase , superoxide dismutase , and glutathione reductase activities as control cells . ^^^ PC 12 cells overexpressing bcl 2 had a twofold increase in superoxide dismutase and catalase activity when compared with matched control transfected cells . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Other research has shown that ( ) deprenyl can induce altered expression of a number of genes in preapoptotic neurons both in vitro and in vivo , including the genes for superoxide dismutase ( SOD ) 1 and 2 , BCL 2 and BCL XL , nitric oxide synthase , c JUN , and nicotinamide adenine dinucleotide dehydrogenase . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The onco proteins Bcl 2 and Bax and the scavenger proteins Cu / Zn superoxide dismutase ( SOD 1 ) and Mn superoxide dismutase ( SOD 2 ) are among the 40 50 proteins whose synthesis is altered by ( ) deprenyl . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The onco proteins Bcl 2 and Bax and the scavenger proteins Cu / Zn superoxide dismutase ( SOD 1 ) and Mn superoxide dismutase ( SOD 2 ) are among the 40 50 proteins whose synthesis is altered by ( ) deprenyl . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Total Superoxide Dismutase activity was induced by oxidative t BOOH treatment in bcl 2 transfected cells , which also accumulated less damage to membrane lipids and proteins , as assessed by TBA RS and carbonyl formation respectively . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Superoxide dismutase ( SOD ) and catalase activity , and IL 12 and bcl 2 levels , were decreased at > 6 mm ; total protein and IL 6 concentrations were increased adjacent to > 6 mm , as compared to < or =3 and 4 6 mm , sites . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Astrocytes overexpressing bcl 2 had elevated glutathione levels ( 130 200 % ) , increased superoxide dismutase ( 170 % ) and glutathione peroxidase ( 140 % ) activities compared with beta galactosidase expressing controls . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The expression of TRPM 2 ( a marker for programmed cell death ) , bcl 2 ( the product of which has been shown to prevent apoptosis ) , superoxide dismutase , and catalase genes was studied at different time intervals after irradiation . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Moreover , transgenic HD mice had normal striatal levels of NMDA receptors , calbindin D28k ( calcium buffer ) , superoxide dismutase activity ( antioxidant enzyme ) , Bcl 2 ( anti apoptotic protein ) , heat shock protein 70 ( stress induced anti apoptotic protein ) , and citrate synthase activity ( mitochondrial enzyme ) . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In this study , we have compared the toxicity of amyloid beta peptide on cultured cortical neurons from control mice and transgenic mice expressing either human copper zinc superoxide dismutase or human Bcl 2 , two proteins that protect cells against oxidative damage . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Therefore , in 46 gliomas ( including astrocytomas , oligodendrogliomas , oligo astrocytomas , and glioblastomas ) , the relationship of apoptosis and necrosis and the expression of apoptosis promoting ( p 53 , bax , Fas , Fas L ) and inhibiting ( bcl 2 ) factors as well as of different isoforms of NOS ( NOSb , NOSe , NOSi ) and manganese superoxide dismutase ( MnSOD ) were studied . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| This level of protection is comparable with the level of protection seen with copper / zinc superoxide dismutase and the anti apoptotic gene bcl 2 that had been similarly transfected . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We investigated the possible roles of mitochondrial manganese superoxide dismutase ( MnSOD ) and bcl 2 in etoposide induced cell death in acute myeloblastic leukaemia ( AML ) using two subclones of the OCI / AML 2 cell line , the etoposide sensitive ( ES ) and the etoposide resistant ( ER ) , as models . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| After determining that there were no CuZnSOD mutations present , we measured superoxide production from mitochondria and manganese superoxide dismutase ( MnSOD ) , glutathione peroxidase , NFkappaB , Bcl 2 and Bax by immunoblot . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Recently , genetic manipulation of wild type animals has yielded species that over or under express genes such as , copper zinc superoxide dismutase , manganese superoxide dismutase , nitric oxide synthase , and the Bcl 2 protein . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Studies using transgenic mice expressing mutant superoxide dismutase 1 ( SOD 1 ) , a model for one form of ALS , established that several proteins were neuroprotective , including calbindin , bcl 2 , and growth factors . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The transcription factor NF kappa B can prevent neuronal death in experimental models of neurodegenerative disorders by inducing the expression of anti apoptotic proteins including Bcl 2 and manganese superoxide dismutase . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Methamphetamine ( METH ) induced alterations in the expression of p 53 and bcl 2 protein were studied in the striatum of wild type , neuronal nitric oxide synthase knockout ( nNOS / ) and copper zinc superoxide dismutase overexpressed ( SOD Tg ) mice . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction analysis revealed that up regulation of the anti apoptotic genes for Bcl 2 , Bcl 10 , and manganese superoxide dismutase was observed in PEDF treated immature but not mature neurons . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| BCL 2 , however , does not change the activities of the major cellular antioxidant enzymes superoxide dismutase , catalase or glutathione peroxidase . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Animal studies have confirmed efficacy in the use of specific targeting of molecules regulating cancer growth ( EGF receptor [ EGFR ] , super oxide dismutase [ SOD ] , cyclin D 1 , E1A and Bcl 2 ) . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The delivery of transgenes capable of interfering with antigenic recognition and / or cell death [ e . g . , Fas ligand ( FasL ) , Bcl 2 , Bcl XL ] as well as imparting tolerance / immunoregulation [ e . g . , interleukin ( IL ) 4 , IL 10 , transforming growth factor ( TGF ) beta ] , or cytoprotection [ e . g . , heme oxygenase 1 ( HO 1 ) , catalase , manganese superoxide dismutase ( MnSOD ) ] may prevent recurrent type 1 diabetes in islet transplantation and offer a promising form of immunotherapy . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In the wild type animals , anti apoptotic Bcl 2 was decreased by ethanol treatment , but the pro apoptotic c Jun N terminal kinase ( JNK ) was markedly diminished by ethanol exposure , while the activity of the protective antioxidant superoxide dismutase ( SOD ) was significantly enhanced . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We investigated the effect of exogenous Bcl 2 on motor neurons in transgenic mice expressing human Cu / Zn superoxide dismutase with a G93A mutation ( G93A mice ) , using adenoviral vectors with a cassette for Bcl 2 ( AxCALNLBcl 2 ) and Cre recombinase ( AxCANCre ) to express Bcl 2 by Cre loxP recombination . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis , as well as increased mitochondrial efficiency , superoxide dismutase activity , and Bcl 2 : Bax ratio . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In transplant surgery , the possible use of lecithinized superoxide dismutase to protect donor organs against cold ischaemic and reperfusion injury has been reported , and work with a rat model showed that blockade of caspase 3 can ameliorate reperfusion injury by upregulating bcl 2 and inhibiting TNF alpha . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| To further test this hypothesis , brain derived neurotrophic factor ( BDNF ) , B cell lymphoma protein 2 ( Bcl 2 ) , and copper zinc superoxide dismutase ( Cu / Zn SOD ) were examined immunohistochemically in hippocampal neurons of Sprague Dawley rats following daily treatment with 5 or 10 mg / kg of amitriptyline or venlafaxine for 21 days . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Sequential analyses were made following ethanol exposure on these two postnatal days , with assessments of NTFs nerve growth factor ( NGF ) , brain derived neurotrophic factor ( BDNF ) , neurotrophin 3 ( NT 3 ) , and neurotrophin 4 ( NT 4 ) ; apoptosis related proteins Bcl 2 , Bcl xl , Bax , Akt and c jun N terminal kinase ( JNK ) ; antioxidants superoxide dismutase , glutathione reductase and catalase ; and ROS . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| METHODS : Assessments were made of neurotrophic factors nerve growth factor , brain derived neurotrophic factor , neurotrophin 3 , and neurotrophin 4 ; apoptosis related proteins Bcl 2 , Bcl xl , Bax , Bcl xs , Bad , phosphorylated Bad , phosphorylated Akt , and phosphorylated c Jun N terminal kinase ; and the antioxidants superoxide dismutase , glutathione reductase , and catalase . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The GAPDH binding is associated with decreased synthesis of pro apoptotic proteins like BAX , c JUN and GAPDH but increased synthesis of anti apoptotic proteins like BCL 2 , Cu Zn superoxide dismutase and heat shock protein 70 . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| These data suggest that susceptibility to lipid peroxidation , expression of the scavenging enzyme Mn superoxide dismutase and of the anti apoptotic protein bcl 2 , may contribute to the maturation dependent vulnerability of OLs to oxidant injury . . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Selegiline and its metabolite , desmethylselegiline , reduce apoptosis by altering the expression of a number of genes , for instance , superoxide dismutase , Bcl 2 , Bcl xl , NOS , c Jun , and nicotinamide adenine nucleotide dehydrogenase . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 expression using retrograde transport of adenoviral vectors inhibits cytochrome c release and caspase 1 activation in motor neurons of mutant superoxide dismutase 1 ( G93A ) transgenic mice . ^^^ We explored a possible mechanism of the neuro protective effects of exogenous human Bcl 2 expression on motor neurons of transgenic mice expressing human Cu / Zn superoxide dismutase with a G93A mutation ( G93A mice ) , using retrograde transport and a Cre loxP recombination system employing adenoviral vectors . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| WEHI7 . 2 mouse thymoma cells selected for resistance to hydrogen peroxide or transfected with thioredoxin , manganese superoxide dismutase , catalase or bcl 2 showed resistance to ART compared to the parental cell line . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| However , neither JNKI 1 nor JBD did influence IL 1beta induced NO synthesis or iNOS expression or the transcription of the genes encoding mitochondrial manganese superoxide dismutase ( MnSOD ) , catalase ( CAT ) , glutathione peroxidase ( GPx ) , glutathione S transferase rho ( GSTrho ) , heat shock protein ( HSP ) 70 , IL 1beta converting enzyme ( ICE ) , caspase 3 , apoptosis inducing factor ( AIF ) , Bcl 2 or Bcl xL . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We investigated the effects of dopaminergic stimulation on anti apoptotic protein Bcl 2 , pro apoptotic enzyme caspase 3 , and anti oxidant / anti apoptotic enzyme Cu / Zn superoxide dismutase ( SOD ) in human lymphocytes exposed to dopamine ( DA ) . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Transgenic mice have been generated expressing molecules ranging from Bcl 2 and Bcl 2 family members to CD 95 , superoxide dismutase and rhodopsin . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The DMN model rats were administered with idoxifene or E 2 , and were examined activity of superoxide dismutase ( SOD ) and glutathione peroxidase ( GPx ) and expression of Bcl 2 family proteins in the liver . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| To explore the mechanism for these findings , we examined protein levels of c IAP 1 , c IAP 2 , and Bcl 2 as well as manganese superoxide dismutase and c Jun NH 2 terminal kinase activity . ^^^ These studies showed that protein levels of c IAP 1 and Bcl 2 were significantly lower in the IkappaBalphaDeltaN mice , whereas there was no change in c IAP 2 levels , manganese superoxide dismutase , or c Jun NH 2 terminal kinase activity . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The ability of astrocytes to protect neurons against the toxic action of free radicals depends on their specific energy metabolism , high glutathione level , increased antioxidant enzyme activity ( catalase , superoxide dismutase , glutathione peroxidase ) and overexpression of antiapoptotic bcl 2 gene . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| METHODS : Mouse myocardium of ischemia / reperfusion model was observed for evaluating the activity of superoxide dismutase ( SOD ) , the level of malondialdehyde ( MDA ) , the apoptotic index of cardial myocyte and the expression of apoptosis correlation protein bcl 2 and bax . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In this study , we measured the lymphocyte levels of proteins involved in apoptosis regulation , such as Bcl 2 , the peripheral benzodiazepine receptor ( PBR ) , caspase 3 , and Cu / Zn superoxide dismutase ( Cu / Zn SOD ) , in patients with Parkinson ' s disease ( PD ) , either untreated or under therapy with dopaminergic agents ( l Dopa alone or l dopa + dopamine agonists ) and in healthy volunteers . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Twenty four hour DA 1 10 3 10 ( 6 ) M or 5 10 3 10 ( 4 ) M had no effect on PBMC expression of Cu / Zn superoxide dismutase or Bcl 2 ; however , DA 5 10 3 10 ( 4 ) M decreased caspase 3 activity . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Serum creatinine , blood urea nitrogen , kidney malondialdehyde ( MDA ) level , and superoxide dismutase ( SOD ) were determined as well as examining the kidneys histologically with immunohistochemistry for Bcl 2 , and ICAM 1 . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| One kidney was used for immunohistological examination of osteopontin , superoxide dismutase ( SOD ) , p 65 , p 53 and bcl 2 expression , in situ hybridization of osteopontin and detection of apoptosis , while the other was used for quantitative analysis of SOD activity . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We have observed that thioredoxin ( Trx ) mediates the induction of mitochondrial manganese superoxide dismutase ( MnSOD ) and Bcl 2 during preconditioning induced hormesis . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Redox up regulated expression of rat liver manganese superoxide dismutase and Bcl 2 by thyroid hormone is associated with inhibitor of kappaB alpha phosphorylation and nuclear factor kappaB activation . ^^^ Within this time interval , liver manganese superoxide dismutase ( MnSOD ) activity and the protein expression of MnSOD and Bcl 2 are enhanced . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Apoptosis was measured and the differential response of normal and cancer cells was correlated with the expression of bcl 2 , bax , GSH , and manganese superoxide dismutase ( MnSOD ) . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| NF kappaB activation can prevent the death of neurons by inducing the production of antiapoptotic proteins such as Bcl 2 , IAPs and manganese superoxide dismutase ( Mn SOD ) . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Changes in biochemical parameters , the content of glutathione ( GSH ) and the activity of superoxide dismutase ( SOD ) in liver tissue , Bcl 2 and Bax protein expression and morphological changes of liver tissue were compared between both groups . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Increases in apoptosis , Bax , lipid peroxidation product malondialdehyde , LDH , and decreases in Bcl 2 , superoxide dismutase , and glutathione peroxidase were observed in TNF alpha treated cells . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Apoptosis in ALS is not restricted to motoneurons : Bcl 2 expression is increased in post central cortex , adjacent to the affected motor cortex . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We searched for the presence of apoptotic cell death and studied the distribution of bcl 2 , an oncoprotein that counteracts apoptosis , in amyotrophic lateral sclerosis ( ALS ) . ^^^ Immunocytochemically , the overall distribution of Bcl 2 did not differ between ALS and non neurological controls . ^^^ In ALS , however , we found variable degrees of increased Bcl 2 expressed in the nuclei and in the cytoplasm . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| To study the potential role of apoptosis in the degeneration of these motor neurons , in situ hybridization was used to measure the expression of two apoptotic cell death genes , bcl 2 and bax , in control and ALS lumbar spinal cord sections . ^^^ Surviving lamina 9 motor neurons in ALS spinal cord sections also expressed bcl 2 mRNA , but at levels that were significantly and selectively decreased ( 4 . 7 fold ) compared with controls . bax mRNA hybridization signal was detected in several cells throughout the gray matter in control and ALS lumbar spinal cord , but was significantly and selectively increased ( 2 . 8 fold ) in ALS motor neurons . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In contrast , the antiapoptotic protein Bcl 2 is decreased in the mitochondrial enriched membrane compartment of vulnerable regions in ALS , but is increased in the cytosol , whereas Bcl xL levels are unchanged in both subcellular compartments . ^^^ Coimmunoprecipitation experiments showed that Bax Bax interactions are greater in the mitochondrial enriched membrane compartment of ALS motor cortex compared with controls , whereas Bax Bcl 2 interactions are lower in the membrane compartment of ALS motor cortex compared with controls . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To investigate if degeneration of motor neurons in amyotrophic lateral sclerosis ( ALS ) is related to altered levels of the apoptosis regulating proteins Bcl 2 and Bax . ^^^ MATERIAL AND METHODS : The immunoreactivity of Bcl 2 , Bax and ICH 1L were compared in ALS and control spinal cord motor neurons by immunohistochemical analysis and motor neurons with DNA fragmentation were identified by the TUNEL method . ^^^ RESULTS : The results demonstrate an increased expression of Bax in the ALS material as compared to controls but no change in Bcl 2 and ICH 1L expressions . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , we have demonstrated that overexpression of Bcl 2 , a protein that inhibits apoptosis , attenuates neurodegeneration produced by the familial ALS linked SOD 1 mutant G93A ( mSOD 1 ) . ^^^ That these changes contribute to the neurodegenerative process in this model of ALS is supported by our observations in double transgenic mSOD1 / Bcl 2 mice in which the pernicious increase of Bax is tempered by an increase in formation of Bcl 2 : Bax heterodimers . ^^^ Based on these findings , it may be concluded that Bcl 2 family members appear as invaluable targets for the development of new neuroprotective therapies in ALS . . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno associated virus encoding Bcl 2 . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Effect of overexpression of wild type and mutant Cu / Zn superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide , 4 hydroxynonenal or serum deprivation : potentiation of injury by ALS related mutant superoxide dismutases and protection by Bcl 2 . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The strongest body of evidence supporting this comes from the findings that , in ALS , changes in the levels of members of the Bcl 2 family of oncoproteins results in a predisposition towards apoptosis , there is increased expression or activation of caspases 1 and 3 , and the dying motor neurones in human cases exhibit morphological features reminiscent of apoptosis . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Because BH 3 only members of the Bcl 2 family have pro apoptotic activity , we examined the expression of the BH 3 only peptide harakiri ( Hrk ) in the spinal cord of ALS patients . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In sporadic ALS , an involvement of pathways involving p 53 and Bcl 2 family members appears possible if not likely , but is not established . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We provide evidence that the pharmacological induction of NF kappaB dependent transcription and bcl 2 gene expression is neuroprotective in ALS mice by inhibiting programmed cell death . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In addition , Mcl 1 was found to interact with Bax , a member of the Bcl 2 family that promotes cell death as a homodimer but that can heterodimerize with Bcl 2 to promote cell viability . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| These mutagenesis results can be interpreted to suggest that Bcl 2 has separate binding sites that are responsible for homodimer and heterodimer formation . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Thus , in this paradigm , either Bcl 2 functions as a homodimer or essential sequences lie outside of the BH 1 or BH 2 domains . . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In might be implied that in the glioma cells , excessive expressions of Bcl 2 and Bax alpha would favor the formation of the Bax alpha / Bax beta heterodimer or the Bax beta / Bcl 2 heterodimer rather than the Bax beta / Bax beta homodimer , which might be presumed to be functional proteins . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Cell sensitivity to programmed cell death is primarily modulated by members of the Bcl 2 family , as the balance of homodimer or heterodimer formation between proapoptotic and antiapoptotic members defines apoptosis susceptibility in the great majority of cellular contexts . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated Bad , an apoptotic member of the Bcl 2 family , can not bind to Bcl xL and results in Bcl xL homodimer formation and subsequent antiapoptotic activity . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis reveals that the different domains of BNIP 3 have been conserved throughout evolution . ceBNIP 3 contains a C terminal transmembrane ( TM ) domain , a conserved domain ( CD ) of 19 amino acids , a BCL 2 homology 3 ( BH 3 ) like domain and a PEST sequence . ceBNIP 3 is expressed primarily as a 25 kDa monomer and a 50 kDa homodimer . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We investigated the role of NF kappaB 1 ( p 50 ) homodimers in the expression of Bcl 2 in two murine B cell lymphoma cell lines : LY as , an apoptosis proficient line with low Bcl 2 protein expression and no nuclear NF kappaB activity , and LY ar , a nonapoptotic line with constitutive p 50 homodimer activity and 30 times more Bcl 2 protein expression than LY as . ^^^ We found that nuclear p 50 homodimer activity correlated with Bcl 2 expression in these cell types and identified several sites within the bcl 2 5 ' flanking region that p 50 was capable of binding . ^^^ We conclude that the p 50 homodimer is capable of transcriptional activation of the bcl 2 gene and suggest that its nuclear activity contributes to the expression of bcl 2 in LY ar cells . . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We investigated the ability of inhibitors with specificities for the proteasome and for another protein degradation enzyme , calpain , to sensitize a murine B cell lymphoma with constitutive NF kappa B 1 homodimer activity and high expression of Bcl 2 protein to radiation induced apoptosis . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The MEK / ERK pathway acts upstream of NF kappa B 1 ( p 50 ) homodimer activity and Bcl 2 expression in a murine B cell lymphoma cell line . ^^^ In the present study , we investigated the upstream signals leading to p 50 homodimer activation and Bcl 2 expression . ^^^ Treatment of LY ar cells with the MEK inhibitors PD 98059 , U 0126 , and PD 184352 led to a loss of phosphorylated ERK 1 and ERK 2 , a reversal of nuclear p 50 homodimer DNA binding , and a decrease in Bcl 2 protein expression . ^^^ We conclude that the MEK / ERK pathway acts upstream of p 50 homodimer activity and Bcl 2 expression in this B cell lymphoma cell system and suggest that the use of MEK inhibitors could be useful clinically in combination with ionizing radiation to treat lymphoid malignancies . . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Here we mapped the interface of the Bcl 2 homodimer in a cell free system using site specific photocross linking . ^^^ Bcl 2 homodimer specific photoadducts were detected from 11 of 17 sites studied . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| By preventing the transferring of the Bax protein from cell plasma to mitochondrion membrane , it takes the advantage of Bcl 2 in forming Bcl 2 / Bax homodimer so as to prevent the opening of the permeability transition pore to avoid the changing of mitochondrion membrane potential and the destruction of biosynthesis caused by the mitochondrion release of apoptosis inducing factors and to reach the objective of restraining apoptosis . . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Simultaneously IP : Bcl 2 / WB : Bax showed that a higher quantity of Bax protein was bound in the heterodimer form to Bcl 2 protein as opposed to the quantity of pro apoptotic Bax protein potentialy bound in the homodimer form . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the CD8alphaalpha homodimer is also transiently up regulated on influenza A virus specific CD8alphabeta T cells after infection in vivo , temporally correlating with increased levels of the memory T cell development and survival related molecules IL 7Ralpha and Bcl 2 , respectively . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In addition , selegiline may act through a mechanism unrelated to MAO B to increase neurotrophic factor activity and upregulate molecules such as glutathione , SOD , catalase , and BCL 2 protein , which protect against oxidant stress and apoptosis . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Collectively , these data indicate that the gonadotropin mediated inhibition of apoptosis in rabbit luteal cells involves enhanced expression of the oxidative stress response gene , manganese containing SOD , whose protein product may then function to protect luteal cells directly from the damaging effect of reactive oxygen species and / or indirectly by acutely down regulating expression of Bax , a prooxidant member of the Bcl 2 protein family . . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| They also demonstrate that this protection is not associated with significant alterations in SOD activity , but is associated with the induction of Bcl 2 and TIMP 1 . . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical study on the distribution of Bcl 2 and Bax in the central nervous system of the transgenic mice expressing a human Cu / Zn SOD mutation . ^^^ In the present study , we performed immunohistochemical studies to investigate the changes of Bcl 2 and Bax in the central nervous system of the transgenic mice expressing a human Cu / Zn SOD mutation . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Cu / Zn superoxide dismutase ( SOD ) and Mn SOD were modestly induced , and Bcl 2 was modestly reduced ; however , several other stress genes ( catalase , heat shock protein 70 , and p 53 ) were unaltered . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis of Bcl 2 , Bcl xL , Bad , Caspase 3 , PDK 1 , and phospho Akt also revealed SOD mediated changes in gene expression consistent with protection and decreased apoptosis . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| We examined the influence of ROS on the phosphorylation and complex formation of Bcl 2 family proteins in Mn superoxide dismutase ( SOD ) antisense transfected squamous cell carcinoma cells , OSC 4 cells . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The results showed that the decrease of GPx activity , T AOC , SOD activity , the fluidity of cell membrane , the Delta psi ( m ) , and the mRNA expression of c myc , bcl 2 , GPx , and TR of VSMCs and the increase of MDA , ROS generation , and intracellular Ca ( 2+ ) , significantly induced by Triol ( 10 microM , 24h ) were inhibited to a different extent , respectively , when cells were pretreated with sodium selenite ( 50 nM , 12 or 24h ) before exposure to Triol . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Choline / M ( 3 ) mAChR activated several survival signaling molecules ( antiapoptotic proteins Bcl 2 and ERKs ) , increased endogenous antioxidant reserve ( SOD ) , and reduced apoptotic mediators ( proapoptotic proteins Fas and p 38 MAPK ) and intracellular Ca2+ overload . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that the protective effects of adiponectin on MPP+ induced apoptosis may be ascribed to its anti oxidative properties , anti apoptotic activity via inducing expression of SOD and catalase , and regulation of Bcl 2 and Bax expression . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| RESULT : Intestinal / R resulted in histopathological changes in intestinal mucosa , increased Chiu ' s scores , apoptosis index , IWC and MDA content , and reduced SOD activity and the protein expression of Bcl 2 significantly ( P < 0 . 01 ) . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| In contrast , overexpression of bcl 2 , which also rescues these cells form loss of trophic support , was equally effective in saving the cells in the SOD 1 downregulation paradigm . ^^^ |
|
| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| The oncoprotein BCL 2 and the scavenger protein SOD 1 have been shown to reduce apoptosis by facilitating closure of the PTP . ^^^ A number of agents have been shown to maintain BCL 2 and / or SOD 1 synthesis in damaged nerve cells and thereby reduce apoptosis . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 transfectants of both cell lines were more resistant to H ( 2 ) O ( 2 ) and showed increases in GSH level and Cu / Zn superoxide dismutase ( SOD 1 ) activity , but not in Mn superoxide dismutase , glutathione peroxidase , or glutathione reductase activities . ^^^ |
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| Interacting proteins: P00441 and P10415 |
Pubmed |
SVM Score :0.0 |
| Another glial activation related gene ( CTSS ) was slightly up regulated in obex , whereas constitutive expression was detected for SOD 1 , YWHAZ , PRNP , and the apoptosis related genes BCL 2 , MCL 1 , and BAX . ^^^ |
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