| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.81919808 |
| When a small amount of NADH cytochrome b 5 reductase is bound liposomes simultaneously with cytochrome b 5 , the two proteins catalyze the reduction of cytochrome c by NADH . 0.81919808^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.69136774 |
| We have demonstrated that the interaction domain of cytochrome b 5 with cytochrome c can be mapped from a comparison of dissociation volumes of these modified cytochrome b 5 cytochrome c complexes with the native complex . 0.69136774^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :2.2216636 |
| The interactions between recombinant cytochrome b 5 and its mutants with cytochrome c were studied by using optical difference spectra . 2.2216636^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.60285912 |
| The variation of these thermodynamic parameters indicates that the strength of mutual interactions between cytochrome c and cytochrome b 5 or its mutants has the following order : Cyt c / Cyt b 5 > Cyt c / Cyt b 5 E56A > Cyt c / Cyt b 5 E44A > Cyt c / Cyt b 5 E44 / 56A . . 0.60285912^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.55594883 |
| The binding between cytochrome c and cytochrome b 5 was studied by optical difference spectra of cytochrome c and variants of cytochrome b 5 . 0.55594883^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.51938625 |
| Experimentally , the interaction of cytochrome c with cytochrome b 5 immobilized on a negatively charged monolayer has been characterized by AG SPR , and both the specific and the nonspecific interactions were quantitatively analyzed . 0.51938625^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Temperature dependence and effects of axial coordination on the spectra of cytochrome c and cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Resonance Raman spectra were measured for various C type cytochromes ( mammalian cytochrome c , bacterial cytochrome c 3 , algal photosynthetic cytochrome f , and alkylated cytochrome c ) and a B type cytochrome ( cytochrome b 5 ) in their reduced and oxidized states . ( 1 ) For ferrous alkylated cytochrome c , a Raman line sensitive to the replacement of an axial ligand of the heme iron uas found around 1540 cm=1 . ^^^ Accordingly two axial ligands are likely to be histidine and methionine as in cytochrome c . ( 3 ) For ferrous cytochrome c 3 , the frequency of the ligand sensitive Raman line was between those of cytochrome c and cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Studies on the reoxidation of W ( 5 ) and reduced heme by O 2 and by cytochrome c suggest that the cytochrome b 5 of sulfite oxidase is the site of electron transfer to cytochrome c , whereas oxidase activity is the property of the molybdenum center . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The reductase could reduce some redox dyes as well as cytochrome c , but could not catalyze the reduction of cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The heme fragment can mediate electron transfer between pig liver microsomal NADH cytochrome b 5 reductase and cytochrome c . ^^^ Isolation of functional heme and molybdenum domains of sulfite oxidase after tryptic cleavage has demonstrated conclusively that the cytochrome b 5 region of the molecule is required for electron transfer to the physiological acceptor , cytochrome c . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| On the other hand , literature data indicate similar electron transfer rates between cytochrome c on one hand , cytochrome b 5 and cytochrome b 2 core on the other hand . ^^^ Biol . 102 , 563 568 ) for the cytochrome c cytochrome b 5 interaction . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Following their isolation from a homogenate containing the combined livers of 14C leucine injected experimental animals and 3H leucine injected control animals , purified fractions of the following proteins were prepared : microsomal cytochrome b 5 , cytochrome P 450 , NADH cytochrome b 5 reductase , NADPH cytochrome P 450 reductase and proteolipids , outer mitochondrial membrane cytochrome b 5 , NADH cytochrome b 5 reductase and proteolipids , inner mitochondrial membrane cytochrome c , NADH dehydrogenase and proteolipids , intermitochondrial membrane cytochrome b 5 and circulating serum albumin . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The solubilization of four integral membrane proteins ( i . e . cytochrome b 561 of the chromaffin granule membrane , cytochrome b 5 of the endoplasmic reticulum and the mitochondrial b type cytochrome ( s ) as well as cytochrome c oxidase ) has been studied at 0 degrees C using the non ionic detergents of the Triton 10 series having the common hydrophobic 4 ( 1 , 1 , 3 , 3 tetramethylbutyl ) phenoxy ( t octyl phenoxy ) group and a variable average number ( n ) of polar ethylene oxide units added . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| We observe in cytochrome c that the shape of the excitation profile agrees with the absorption band shape , while in cytochrome b 5 it does not . ^^^ In addition , we observe in cytochrome b 5 a linewidth substantially larger than that in cytochrome c . ^^^ From our data we conclude that the excited state lifetime in cytochrome c is longer than that in cytochrome b 5 and that in cytochrome b 5 the relaxation of the pi pi * excited state configuration of the porphyrin ring is different in the 10 direction than in the y direction . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Effect of modification of individual cytochrome c lysines on the reaction with cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Interaction between cytochrome c and cytochrome b 5 . ^^^ The reduction of cytochrome c by cytochrome b 5 was studied over a wide range of ionic strengths in four different buffer systems . ^^^ This indicates that the interaction between the two proteins is best described as the sum of n complementary charge interactions , each involving a specific lysine on cytochrome c and a specific carboxyl group on cytochrome b 5 . ^^^ Ultracentrifugation and gel permeation techniques were used to demonstrate that cytochrome b 5 and cytochrome c formed a stable complex at low ionic strength . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The reductase , of molecular weight 42000 and containing two chromophores , an FMN and an iron sulfur complex ( EPR at g = 1 . 95 ) , reduces both one electron and two electron acceptors ( i . e . , ferricyanide , 2 , 6 dichloroindophenol , cytochrome c , and cytochrome b 5 ) at an optimum pH of 8 . 0 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The folding of the protein resembles that of hemerythrin and tobacco mosaic virus protein and shows a different topology from that of cytochrome b 5 , cytochrome c , or the globins . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The enzyme contains molybdenum and a cytochrome b 5 type haem , is localized in the mitochondrial intermembrane space and transfers electrons from sulphite to cytochrome c on the inner membrane . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| A variety of electron acceptors have been compared as to rate with the following result : ferricyanide greater than cytochrome c greater than cytochrome b 5 greater than glyoxylate greater than dichlorophenolindophenol . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Neither inhibitor affected the activity of cytochrome c reductase , cytochrome b 5 reductase or cytochrome P 450 reductase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Significant increases in the mean hepatic weight , the concentrations of hepatic microsomal protein , cytochrome P 450 , cytochrome b 5 , and cytochrome c reductase activity occurred in the aminals given a ration containing 250 mg of hexachlorobenzene / kg for 21 days , when compared with their nontreated controls . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The extent of solubilization was compared with that of protein , rotenone insensitive NADH cytochrome c reductase or NADH cytochrome b 5 reductase , which have been shown to associate with microsomal membrane rather than luminar contents . ^^^ When 0 . 05 % of DOC which was capable of releasing luminar contents of microsomal vesicles was applied to microsomal suspension , only a limited part of NADH cytochrome b 5 reductase , rotenone insensitive NADH cytochrome c reductase or T 4 5 ' deiodinase activity was solubilized . ^^^ Solubilization of protein , NADH cytochrome b 5 reductase or rotenone insensitive NADH cytochrome c reductase was increased abruptly to 66 % , 58 % or 63 % , respectively . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NADH ferricyanide and cytochrome c reductases , cytochrome b 5 , NADPH cytochrome c reductase and cytochrome P 450 , were either solubilized or inactivated by one or both treatments . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The effect of these esters on the microsomal enzymes in the liver such as cytochrome P 450 , cytochrome b 5 , aniline and hexobarbital difference spectra and NADPH dependent cytochrome c reductase was determined . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Only 1 electron was consumed per hemin molecule , and reoxidation of the reduced heme is accompanied by the transfer of 1 electron to oxidizing agents such as cytochrome c , cytochrome b 5 , or potassium ferricyanide . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Riboflavin , FMN , oxidized cytochrome b 5 , oxidized or reduced cytochrome c , NAD ( H ) , and NADP ( H ) were ineffective in the reaction . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Effect of KCl on the interactions between NADPH : cytochrome P 450 reductase and either cytochrome c , cytochrome b 5 or cytochrome P 450 in octyl glucoside micelles . ^^^ Significant dissociation of FMN from NADPH : cytochrome P 450 reductase resulted in loss of the activity for reduction of cytochrome b 5 as well as cytochrome c and cytochrome P 450 . ^^^ The reductions of cytochrome c and detergent solubilized cytochrome b 5 by NADPH : cytochrome P 450 reductase were greatly increased in the presence of high concentrations of KCl , although the stimulatory effect of the salt on cytochrome P 450 reduction was less significant . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Phospholipase A 2 hydrolysis of neutral and negatively charged lipid membranes modified by positively charged proteins has been studied using liposomes composed of either dioleoylphosphatidylcholine ( DOPC ) or dioleoylphosphatidylglycerol ( DOPG ) alone or their equimolar mixture in the presence of cytochrome c , histone H 1 , cytochrome b 5 , and polylysine . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Genetic engineering of redox donor sites : measurement of intracomplex electron transfer between ruthenium 65 cytochrome b 5 and cytochrome c . ^^^ The de novo design and synthesis of ruthenium labeled cytochrome b 5 that is optimized for the measurement of intracomplex electron transfer to cytochrome c are described . ^^^ The ruthenium group at Cys 65 is only 12 A from the heme group of cytochrome b 5 but is not located at the binding site for cytochrome c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| This approach was tested using 32 known protein sequences from different cytochrome b 5 , cytochrome c , lysozyme , hemoglobin , and myoglobin proteins . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The amounts of NAD ( P ) H cytochrome c reductases and cytochrome b 5 type , components of microsomal monooxygenase reaction , have been spectrophotometrically measured . 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The anti ( cytochrome b 5 ) IgG inhibited delta 12 hydroxylase , delta 12 desaturase and cytochrome c reductase activity in the microsomes . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| After 72 h following acute administration of selenium ( 7 . 5 mg / kg , i . p . ) , there was a significant inhibition of the activities of aminopyrine ( AM ) N demethylase and ethylmorphine ( EM ) N demethylase , and cytochrome P 450 levels but no change in the activities of aniline ( AN ) hydroxylase , 7 ethoxycoumarin ( EC ) O deethylase , reduced nicotinamide adenine dinucleotide phosphate ( NADPH ) cytochrome c reductase and reduced nicotinamide adenine dinucleotide ( NADH ) ferricyanide reductase , and cytochrome b 5 content . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Vmax values of reductase 2 for the various electron acceptors , namely , 2 , 6 dichlorophenolindophenol , ferricyanide and cytochrome c through cytochrome b 5 were found to be 1 . 9 , 1 . 8 and 2 times higher than those of reductase 1 . 4 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Two of the MAbs partially inhibited cytochrome b 5 mediated NADH cytochrome c reduction catalyzed by liver microsomes ( 24 36 % ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The role of the internal hydrogen bond network in first order protein electron transfer between Saccharomyces cerevisiae iso 1 cytochrome c and bovine microsomal cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Proton linkage of complex formation between cytochrome c and cytochrome b 5 : electrostatic consequences of protein protein interactions . ^^^ Two potentiometric methods have been used to study the pH dependent changes in proton binding that accompany complex formation between cytochrome c and cytochrome b 5 . ^^^ Under all conditions studied , the stoichiometry of cytochrome c cytochrome b 5 complex formation is 1 : 1 with no evidence of higher order complex formation . ^^^ Although the dependence of complex formation on pH for interaction between different species of cytochrome c and cytochrome b 5 are qualitatively similar , they are quantitatively different . ^^^ In particular , complex formation between yeast iso 1 cytochrome c and lipase solubilized bovine cytochrome b 5 occurs with a stability constant that is 10 fold greater than observed for the other two pairs of proteins under all conditions studied . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Investigations of yeast cytochrome c mutants and their complexes with cytochrome b 5 . ^^^ Direct electrochemistry of site specific mutants of yeast iso 1 cytochrome c ( cyt c ) and their complexes with bovine cytochrome b 5 ( cyt b 5 ) has been investigated at edge plane pyrolytic graphite ( EPG ) and bis ( 4 pyridyl ) disulphide modified gold electrodes . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The relative effect of these two nucleotides changed when animals were fed phenobarbital , and paralleled the levels of NADPH cytochrome c reductase , cytochrome P 450 , cytochrome b 5 and NADH cytochrome c reductase ; results with purified NADPH cytochrome c reductase were consistent with these results . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome P 450 , cytochrome B 5 , cytochrome C , and ethylmorphine N demethylase activities were all increased over controls , with most marked increases in the cytochrome P 450 and ethylmorphine N demethylase activities . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NMR characterization of surface interactions in the cytochrome b 5 cytochrome c complex . ^^^ The complex formed in solution by native and chemically modified cytochrome c with cytochrome b 5 has been studied by 1H and 13C nuclear magnetic resonance spectroscopy ( NMR ) . ^^^ Contrary to predictions of recent theoretical analysis , 1H NMR spectroscopy indicates that there is no major movement of cytochrome c residue Phe 82 on binding to cytochrome b 5 . ^^^ The greater resolution provided by 13C NMR spectroscopy permits detection of small perturbations in the environments of cytochrome c residues Ile 75 and Ile 85 on binding with cytochrome b 5 , a result that is in agreement with earlier model building experiments . ^^^ As individual cytochrome c lysyl residues are resolved in the 1H NMR spectrum of N acetimidylated cytochrome c , the interaction of this modified protein with cytochrome b 5 has been studied to evaluate the number of cytochrome c lysyl residues involved in binding to cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Direct electrochemistry of protein protein complexes involving cytochrome c , cytochrome b 5 , and plastocyanin . ^^^ The direct electrochemistry of the cytochrome c / cytochrome b 5 and cytochrome c / plastocyanin complexes has been investigated at edge plane graphite and modified gold electrode surfaces , which are selective for one of the two components of the complex . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| They are bis histidine , as in mammalian cytochrome b 5 , methionine histidine , typified by cytochrome c and lysine histidine , recently recognized by spectroscopic methods in cytochrome f . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The electrochemistry of the redox proteins , cytochrome c , cytochrome b 5 , plastocyanin and ferredoxin at modified gold electrodes has been examined on the basis that electron transfer takes place at electroactive sites which are microscopic in size . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The association of the tryptic fragment of bovine microsomal cytochrome b 5 with cytochrome c has been studied by one and two dimensional 1H NMR spectroscopy . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Amount of cytochrome b 5 and uridine diphosphoglucuronic acid transferase activity were not affected by age , whereas NADPH cytochrome c ( P 450 ) reductase activity actually decreased after weaning . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Hepatic ischemia induced in vivo by ligation of the left hepatic lobe of rats for up to 2 hr had no effect on cytochrome P 450 , cytochrome c reductase , or lobe histology ; however , cytochrome b 5 increased with ischemia duration . ^^^ Reperfusion of tissue previously made ischemic for up to 2 hr was associated with appreciable necrosis as well as decreases in cytochrome P 450 , cytochrome b 5 , cytochrome c reductase , and ethylmorphine demethylation . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Due to their presence in foetal liver or their more rapid evolution , cytochrome b 5 , NADPH cytochrome c reductase , aniline hydroxylase , benzphetamine N demethylase and erythromycin N demethylase did not parallel the ontogenesis of cytochrome P 450 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| On the other hand , no change was observed in reduced nicotinamide adenine dinucleotide phosphate ( NADPH ) cytochrome c reductase activity or cytochrome b 5 content in the hepatic microsomes of the CBD treated rats . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The possible redox linked conformational changes are found to be minimal in contrast with cytochrome c although the procedure additionally highlights aspects of the mobility of certain residues in cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| At 2 , 4 , 8 , 16 , 20 , 24 , or 32 days posttreatment , groups of rats were killed and their livers were analyzed for ( 1 ) cytochrome P 450 , NADPH dependent cytochrome c reductase , cytochrome b 5 and glutathione content or ( 2 ) in vitro irreversible binding of 14CHCl3 derived radiolabel to microsomal protein . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The contents of cytochrome P 450 and cytochrome b 5 , and the NADPH cytochrome c reductase activity in the nasal olfactory mucosa have also been determined . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Both of the reconstituted proteins were found to be capable of transferring electrons to cytochrome c in a reconstituted system dependent on NADH and cytochrome b 5 reductase , thus stimulating the activity of native cytochrome b5 . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Crosslinking of cytochrome c and cytochrome b 5 with a water soluble carbodiimide . ^^^ A water soluble carbodiimide , 1 ethyl 3 ( 3 dimethylaminopropyl ) carbodiimide ( EDC ) , has been used to crosslink horse heart cytochrome c and trypsin solubilized bovine liver microsomal cytochrome b 5 . ^^^ The cytochrome b 5 heme group was readily extracted from each of the 1 : 1 crosslinked complexes by standard techniques , so the crosslinking of heme propionate 7 with Lys 79 of cytochrome c that might have been anticipated on the basis of molecular graphics modeling [ Salemme , F . ^^^ Biol . 102 , 563 568 ] was absent from all peptide maps of 1 : 1 cytochrome c . cytochrome b 5 complexes . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome P 450 , cytochrome b 5 , NADPH cytochrome c reductase , esterases and the activities of six mixed function oxidases were assayed . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Molecular dynamics of a cytochrome c cytochrome b 5 electron transfer complex . ^^^ Cytochrome c and cytochrome b 5 form an electrostatically associated electron transfer complex . ^^^ Previous static modeling studies were extended by molecular dynamics simulations of a cytochrome c cytochrome b 5 intermolecular complex . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The same results were obtained with subchronic treatment of mice with these metabolites ( 5 mg / kg / d , i . v . for 7 d ) , although the effect of 8 beta , 9 beta epoxyhexahydrocannabinol on cytochrome P 450 was not statistically significant . 7 beta Hydroxy delta 8 THC significantly increased nicotinamide adenine dinucleotide phosphate ( NADPH ) cytochrome c reductase and aniline hydroxylase activities by single administration , while the metabolite significantly decreased the contents of cytochrome b 5 and P 450 and p nitrophenol uridine diphosphate glucuronyltransferase activity by the subchronic treatment . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The data are difficult to reconcile with binding of cytochrome c to a cluster of acidic residues in the area of the heme b prosthetic group , as was envisaged for the cytochrome b 5 cytochrome c complex [ Salemme , F . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Chemical modification of cytochrome b 5 , cytochrome c and myoglobin with diethylpyrocarbonate . ^^^ Because of the unexpected ease with which diethylpyrocarbonate displaced the heme from cytochrome b 5 , this same process was investigated in two other hemoproteins , cytochrome c and myoglobin . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Probing the mechanisms of macromolecular recognition : the cytochrome b 5 cytochrome c complex . ^^^ The specificity of complex formation between cytochrome b 5 ( cyt b 5 ) and cytochrome c ( cyt c ) is believed to involve the formation of salt linkages between specific carboxylic acid residues of cyt b 5 with lysine residues on cyt c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Kinetics of flavin semiquinone reduction of the components of the cytochrome c cytochrome b 5 complex . ^^^ The kinetics of flavin semiquinone reduction of the components of the 1 : 1 complex formed by cytochrome c with either cytochrome b 5 or a derivative of cytochrome b 5 in which the heme propionates are esterified ( DME cytochrome b 5 ) have been studied . ^^^ The rate constant for the reduction of horse heart cytochrome c by the electrostatically neutral lumiflavin semiquinone ( LfH ) is unaffected by complexation with native cytochrome b 5 at pH 7 . ^^^ However , complex formation with DME cytochrome b 5 ( pH 7 ) decreases by 35 % the rate constant for cytochrome c reduction by LfH . ^^^ At pH 8 , complex formation with native cytochrome b 5 decreases the rate constant for cytochrome c reduction by LfH markedly , whereas the rate constant for cytochrome c reduction , either unbound or in the complex formed with DME cytochrome b 5 , is increased 2 fold relative to pH 7 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome b 5 , cytochrome c , and cytochrome P 450 interactions with NADPH cytochrome P 450 reductase in phospholipid vesicles . ^^^ Upon incubation of detergent solubilized NADPH cytochrome P 450 reductase and either cytochrome b 5 or cytochrome c in the presence of a water soluble carbodiimide , a 1 ethyl 3 [ 3 ( dimethylamino ) propyl ] carbodiimide ( EDC ) , covalently cross linked complex was formed . ^^^ The binary covalent complex between the flavoprotein and cytochrome b 5 was exclusively observed following incubation of all three proteins including NADPH cytochrome P 450 reductase , cytochrome b 5 , and cytochrome c in L alpha dimyristoylphosphatidylcholine vesicles , and no heterotrimer could be identified . ^^^ The isolated reductase cytochrome b 5 complex was incapable of covalent binding with cytochrome c in the presence of EDC . ^^^ More than 90 % of the cross linked cytochrome c in the purified derivative was rapidly reduced upon addition of an NADPH generating system , whereas approximately 80 % of the cross linked cytochrome b 5 was rapidly reduced . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Hepatic cytochrome P 450 , cytochrome b 5 , and NADPH cytochrome c reductase in chicks and rats fed phenolic monomers , polymers , and glycosides . ^^^ Eight experiments were conducted to determine effects of a phenolic polymer ( Kraft wood lignin , Indulin ) , phenolic glycosides ( cane molasses and wood molasses ) , and phenolic monomers ( vanillin , vanillic acid , ferulic acid , and p coumaric acid ) on liver cytochromes P 450 , cytochrome b 5 , and NADPH cytochrome c reductase in chicks and rats . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Untreated NCI H 322 and NCI H 358 also contained cytochrome b 5 , NADPH cytochrome c reductase and epoxide hydrolase activities . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The interaction of heme nonapeptide ( a proteolytic product of cytochrome c ) with purified NADH : cytochrome b 5 ( EC 1 . 6 . 2 . 2 ) and NADPH : cytochrome P 450 ( EC 1 . 6 . 2 . 4 ) reductases was investigated . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| These results show that the reductase interacts functionally with cytochrome c and cytochromes P 450 on the one hand and cytochrome b 5 on the other through different mechanisms . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Studies of single turnover kinetics with a small molecule ( ascorbate ) or within bound complexes with either cytochrome b 5 or cytochrome c peroxidase demonstrated that redox kinetics are only slightly affected by these substitutions . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In contrast , cytochrome b 5 , NADPH cytochrome c reductase , ethyoxycoumarin O deethylase and the enzymatic activation of ethidium bromide were not affected by fascioliasis whatever pretreatment was given . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Infrared spectroscopic analysis of salt bridge formation between cytochrome b 5 and cytochrome c . ^^^ When cytochrome b 5 is mixed with cytochrome c , under conditions that favor ionic complex formation , changes are seen in protein secondary structure and also in a band at 1562 cm 1 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Similarly , the microsomal NADH cytochrome c reductase system consisting of cytochrome b 5 and its flavoprotein , NADH cytochrome b 5 reductase , was also significantly inhibited by Ebselen . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Effects of two doses of cyproterone acetate ( CA ) and flutamide ( FLU ) ( 50 and 100 mg / kg / 3 days ) on the testicular steroidogenesis in male rats have been investigated , by measuring the content of cytochrome P 450 , cytochrome b 5 and cytochrome c reductase activity in the microsomal fraction . 2 . ^^^ On the other hand , in all cases the cytochrome b 5 and cytochrome c reductase activity remained unchanged . 4 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NADPH : cytochrome c reductase and NADH : cytochrome b 5 reductase were more stable in SD than in HL rat hepatocyte cultures . 16 , 16 Dimethylprostaglandins E 2 and F 2 alpha improved the maintenance of cytochrome P 450 content , MFO activity and NADPH : cytochrome c reductase in the HL rat hepatocyte cultures . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The opposite effect of bivalent cations on cytochrome b 5 reduction by NADH : cytochrome b 5 reductase and NADPH : cytochrome c reductase . ^^^ The effects of bivalent cations on cytochrome b 5 reduction by NADH : cytochrome b 5 reductase and NADPH : cytochrome c reductase were studied with the proteinase solubilized enzymes . ^^^ In contrast , cytochrome b 5 reduction by NADPH : cytochrome c reductase was extremely activated by CaCl 2 or MgCl 2 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Electrostatic analysis of the interaction of cytochrome c with native and dimethyl ester heme substituted cytochrome b 5 . ^^^ The stability of the complex formed between cytochrome c and dimethyl ester heme substituted cytochrome b 5 ( DME cytochrome b 5 ) has been determined under a variety of experimental conditions to evaluate the role of the cytochrome b 5 heme propionate groups in the interaction of the two native proteins . ^^^ Interaction between cytochrome c and the modified cytochrome b 5 was found to produce a difference spectrum in the visible range that is very similar to that generated by the interaction of the native proteins and that can be used to monitor complex formation between the two proteins . ^^^ At pH 8 [ 25 degrees C ( HEPPS ) , 1 = 5 mM ] , DME cytochrome b 5 and cytochrome c form a 1 : 1 complex with an association constant KA of 3 ( 1 ) 10 10 ( 6 ) M 1 . ^^^ The stability of the complex formed between DME cytochrome b 5 and cytochrome c is strongly dependent on ionic strength with KA ranging from 2 . 4 10 10 ( 7 ) M 1 at 1 = 1 mM to 8 . 2 10 10 ( 4 ) M 1 at 1 = 13 mM [ pH 8 . 0 ( HEPPS ) , 25 degrees C ] . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| These shifts are very similar to those observed for the covalently crosslinked complex of cytochrome c peroxidase and horse cytochrome c , but different from those reported for cytochrome c complexes with flavodoxin and cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NMR study of the interaction between cytochrome b 5 and cytochrome c . ^^^ The interaction between horse cytochrome c and the tryptic fragment of bovine liver microsomal cytochrome b 5 in the absence and presence of [ Cr ( ethylenediamine ) 3 ] Cl 3 was studied by 1H NMR spectroscopy . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Activities of reducing enzymes of drug metabolism ( cytochrome P 450 , cytochrome b 5 and NADH : cytochrome c reductases ) , glutathione metabolism enzymes ( glutathione peroxidase , glutathione transferase , glutathione reductase , and gamma glutamyl transpeptidase ) , and free radical scavenging enzymes ( superoxide dismutase , catalase , and quinone reductase ) in tumor were significantly lower than in untreated kidney tissue . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Animals given 1 or 2 g PB for 3 d had higher concentrations of microsomal protein cytochrome b 5 and P 450 and NADPH cytochrome c reductase than control animals ( P less than . 01 ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NADPH : cytochrome c reductase activity was increased by both PB and INH , whereas cytochrome b 5 content was increased by INH only . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Increases of microsomal cytochrome b 5 and P 450 , elevations of NADPH cytochrome C reductase , aminopyrine N demethylase and 7 ethoxycoumarin O deethylase activities and decrease of 3 , 4 benzo ( a ) pyrene hydroxylase activity per cytochrome P 450 were observed after the administration of gomisin A . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| There was a change in the activities of the following enzymes , which could be due either to zinc deficiency and / or food restriction : 1 ) aryl hydrocarbon hydroxylase ; 2 ) cytochrome b ; 3 ) cytochrome c ; and 4 ) cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| These data were compared with hepatic glutathione and with various parameters of the polysubstrate monooxygenase system : cytochrome P 450 , cytochrome c reductase , cytochrome b 5 , and microsomal binding of 14CHCl3 derived radiolabel . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Hepatic and / or cutaneous benzphetamine N demethylase ( BPD ) , NADPH cytochrome c reductase , NADH ferricyanide reductase activities , and the levels of cytochrome P 450 and cytochrome b 5 , remained unchanged following treatment with either topically applied nitroarenes or arenes . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In liver microsomes of rats 5 h after intraperitoneal administration of bromobenzene , the activities of a series of drug metabolizing mixed function oxidases , i . e . , ketamine and aminopyrine N demethylases , methylayapanine and methoxybiphenyl O demethylases , and ethoxycoumarin O deethylase , as well as glutathione and cytochrome b 5 contents were found to be decreased , whereas the activities of microsomal , NADPH dependent cytochrome c and neotetrazolium reductases as well as cytochrome P 450 were unchanged . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Gossypol acetic acid ( GAA ) at the dosage of 30 mg / kg daily for 2 weeks could prolong the sleeping time of pentobarbital , increase the SGPT level , decrease the liver concentration of cytochrome P 450 and GSH content , inhibit the activity of cytochrome C reductase and aminopyrine N demethylase , but was without effect on cytochrome b 5 and aniline hydroxylase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Noticeable impairment in the other components like NADH : cytochrome b 5 reductase , NADPH : cytochrome c reductase , cytochrome b 5 and glucose 6 phosphatase was also observed . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The activities of delta 6 desaturase , NADH cytochrome b 5 ferri reductase , cytochrome b 5 , NADH cytochrome c reductase and microsomal elongation enzymes remained virtually unchanged . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The importance of amino acid composition in determining rates of substitution is illustrated with examples involving cytochrome c , cytochrome b 5 , ras related genes , the calmodulin protein family , and fibrinopeptides . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Levels of cytochrome P 450 and cytochrome b 5 , and activities of NADPH cytochrome c reductase and 7 ethoxycoumarin O deethylase , were found to be significantly decreased in hepatic microsomes prepared from mice killed 24 h after administration of a single intraperitoneal ( i . p . ) dose of adriamycin ( ADR , 5 mg / kg ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The enzyme showed greatest electron acceptor activity with ferricyanide ( 100 % ) , followed by cytochrome c ( 3 . 5 % ) , dichloroindophenol ( 2 . 7 % ) , and cytochrome b 5 ( 0 . 34 % ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In addition to monodehydroascorbate , the enzyme catalyzed the reduction of ferricyanide and 2 , 6 dichloroindophenol but showed little reactivity with calf liver cytochrome b 5 and horse heart cytochrome c . ^^^ Cucumber monodehydroascorbate reductase occurs in soluble form and can be distinguished from NADPH dehydrogenase , NADH dehydrogenase , DT diaphorase , microsome bound NADH cytochrome b 5 reductase , and NADPH cytochrome c reductase by its molecular weight , amino acid composition , and specificity of electron acceptors and donors . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The effect of high salt concentrations upon cytochrome C , cytochrome B 5 , and iron EDTA reductase activities of liver microsomal NADPH cytochrome C reductase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Isolation and characterization of reduced nicotinamide adenine dinucleotide phosphate : ferri cytochrome c oxidoreductase and identification of cytochrome b 5 in the liver of human infants . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Dissociation constants have been determined for complexes of adrenodoxin , hepatoredoxin , cytochrome b 5 heme containing fragment and myoglobin with preparations of cytochrome c immobilized via lysine residues ( adsorbent 1 ) or additionally introduced imidazole groups ( adsorbent 2 ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Use of specific trifluoroacetylation of lysine residues in cytochrome c to study the reaction with cytochrome b 5 , cytochrome c 1 , and cytochrome oxidase . ^^^ The redox reaction rates of these derivatives with cytochrome b 5 , cytochrome c 1 and cytochrome oxidase indicated that the interaction domain on cytochrome c for all three proteins involves the lysines immediately surrounding the heme crevice . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| These lysines are known to play a functional role in the reaction with cytochrome c peroxidase , cytochrome oxidase , cytochrome c 1 , and cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The internal cytochrome c participates in redox reactions with both soluble and insolubilized cytochrome c present externally , and with external cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| During oxidation of exogenous NADH there is a fast and complete reduction of cytochrome b 5 while endogenous or added exogenous cytochrome c become 10 15 % and 100 % reduced , respectively . ^^^ The reoxidation of cytochrome b 5 , after exhaustion of NADH , precedes that of cytochrome c . ^^^ It is concluded that aerobic oxidation of exogenous NADH involves the following pathway : NADH leads to NADH cytochrome b 5 reductase leads to cytochrome b 5 leads to intermembrane cytochrome c leads to cytochrome oxidase leads to oxygen . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| It is concluded that ( 1 ) oxidation of exogenous NADH in the presence of cytochrome c proceeds mostly through NADH cytochrome b 5 reductase and cytochrome b 5 on the outer membrane and then through cytochrome oxidase via the cytochrome c shuttle , and ( 2 ) ATP synthesis during oxidation of exogenous NADH is partly due to oxidation of endogenous substrates and partly to operation of cytochrome oxidase receiving electrons from the outer membrane via cytochrome c . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome b 5 , NADH and NADPH dependent cytochrome c reductase activities were 15 , 6 and 10 fold lower , respectively , in the mammary gland than in the liver microsomes . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Spectrophotometric analysis of the interaction between cytochrome b 5 and cytochrome c . ^^^ The interaction between cytochrome c and the tryptic fragment of cytochrome b 5 has been found to produce a difference spectrum in the Soret region with a maximum absorbance at 416 nm . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The capacities of cytochrome b 5 and cytochrome c oxidase to reduce the succinoylated ferricytochrome c and oxidize succinoylated ferrocytochrome c respectively were decreased to a similar extent . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Lymphocyte samples were simultaneously thawed , phytohemagglutinin activated , and analyzed for benz ( a ) anthracene induced aryl hydrocarbon hydroxylase ( AHH ) levels , [ 3H ] thymidine incorporation , and reduced nicotinamide adenine dinucleotide dependent cytochrome b 5 ( cytochrome c ) reductase activity . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Reduced cytochrome a is low spin ferrous , with parameters similar to those of cytochrome b 5 and cytochrome c . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| H n . m . r . investigation of the interaction between cytochrome c and cytochrome b 5 . ^^^ The interaction between eukaryotic cytochrome c and the tryptic fragment of bovine liver microsomal cytochrome b 5 was studied by 1H n . m . r . spectroscopy , and a procedure was developed that may be generally applicable to the study of macromolecular interactions by n . m . r . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Dissociation constants have been determined for complexes of adrenodoxin , hepatoredoxin , cytochrome b 5 heme containing tryptic fragment and myoglobin with cytochrome c preparations immobilized via lysine residues ( cytochrome c Sepharose 1 ) or additional imidazole groups ( cytochrome c Sepharose 2 ) . ^^^ The efficiency of cytochrome c Sepharose 2 application in the course of adrenodoxin , hepatoredoxin and cytochrome b 5 purification , as well as isolation of cytochrome b 4 heme containing tryptic fragment has been shown . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Electrons resulting from the oxidation of exogenous NADH reduce both cytochrome b 5 and endogenous cytochrome c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In general , the proteolytic digestion had a greater inhibitory effect on oxidation reactions for a given loss of NADPH cytochrome c reductase activity than did flavoprotein antibody ; and of the two proteases , subtilisin , which also diminishes the cytochrome b 5 reduction pathway , had a greater inhibitory effect than trypsin . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| After 21 days on a scorbutogenic diet , microsomal cytochrome P 450 and cytochrome b 5 levels fell by 51 and 32 % , respectively , while cytochrome c reductase activity remained constant . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| There were no significant increases from controls for absolute or relative liver weights , liver microsomal protein concentrations , cytochrome b 5 , cytochrome P 450 or cytochrome c reductase activity in rats dosed repeatedly with 200 mg / kg HQ . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome b 5 content was increased in chicks and young rats , while cytochrome c reductase activity was increased in male and female mice , young rats and chicks and decreased in female guinea pigs . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Gestational and postnatal changes of microsomal NADH : cytochrome b 5 reductase and NADPH : cytochrome c reductase activities were examined in rat brain . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The complex pattern of the behaviour of the activities of aniline hydroxylase , 4 nitroanisole O demethylase , aminopyrine N demethylase and NADH : cytochrome c oxidoreductase was not related to the observed decrease of cytochrome P 450 and cytochrome b 5 contents . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| When reconstituted into phospholipid vesicles , the amphipathic derivative showed substantially reduced Vmax values with the soluble electron acceptors potassium ferricyanide , cytochrome b 5 heme peptide and cytochrome c , and with the membrane bound acceptors amphipathic cytochrome b 5 and stearyl CoA desaturase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Sodium fluoride at a dose level of 5 . 0 mg / kg enhanced aminopyrine N demethylase and NADPH cytochrome c reductase activities and cytochrome P 450 and cytochrome b 5 levels in rat liver , kidney , lung , intestine and testis , whereas acetanilide hydroxylase activity remained unchanged in kidney and lung and was increased in liver , intestine and testis . ^^^ Sodium fluoride at 20 . 0 mg / kg caused a decrease in aminopyrine N demethylase , acetanilide hydroxylase and NADPH cytochrome c reductase activities and cytochrome P 450 and cytochrome b 5 levels in all tissues , except for an increase in NADPH cytochrome c reductase activity in the intestine and testis . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Transfer of cytochrome b 5 and NADPH cytochrome c reductase between membranes . ^^^ NADPH cytochrome c reductase also reduces cytochrome b 5 . ^^^ In contrast , proteins incorporated into liposomes by means of a detergent were not transferred , nor were endogenous cytochrome b 5 and NADPH cytochrome c reductase transferred from microsomes to Golgi membranes or lipid vesicles . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome b 5 content and cytochrome c reductase activity were unaffected by diet . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Clofibrate also promoted a decrease in serum cholesterol and triacylglycerol levels , delta 6 desaturase activity and a suppression of the electron transport chain as measured by NADH cytochrome b 5 reductase and NADH cytochrome c reductase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The membrane enzyme and liver dfp reduced cytochrome c in the presence of detergent solubilized cytochrome b 5 70 80 times faster than in the presence of trypsin solubilized cytochrome b 5 , whereas the cytosol enzyme and liver tfp showed essentially the same low activities with both preparations of cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The levels of hepatic microsomal cytochrome P 450 and cytochrome b 5 and the activities of NADPH dehydrogenase and NADPH cytochrome c reductase were unaffected by morphine treatment . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome c reductase activity and cytochrome b 5 concentration were reduced significantly ( 24 % ) only on day 10 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Comparison of the proposed binding loci for cytochrome b 5 on the methemoglobin subunits with those proposed on cytochrome c reveals considerable structural homology between the cytochrome b 5 binding sites . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Reaction of the antibody with membrane bound cytochrome b 5 inhibits the sarcoplasmic reticulum NADH cytochrome c reductase activity . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome b 5 from rabbit liver microsomes can be an electron intermediate during cytochrome c reduction by metlegoglobin reductase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The treatment also induced cytochrome b 5 content , NADH and NADPH cytochrome c reductase activities ( 1 . 0 1 . 5 fold ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In hepatic microsomes , cytochrome b 5 reductase ( EC 1 . 6 . 2 . 2 ) activity was unaffected by riboflavin deficiency , although NADPH cytochrome c reductase ( EC 1 . 6 . 2 . 4 ) and microsomal flavin content were diminished to approximately half the control values . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The hepatic microsomal cytochrome P 450 , cytochrome b 5 and nicotinamide adenine dinucleotide phosphatase ( NADPH ) cytochrome c reductase activities were found to be elevated in tolerant mice ( 2 mg / day / mouse for 5 days ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The rate equation which represents the reduction of either methemoglobin or cytochrome c was obtained as a function of methemoglobin or cytochrome c , methemoglobin reductase , and cytochrome b 5 by considering the E . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome b 5 and cytochrome c reductase were unaffected at any of the dose levels and cytochrome P 450 was significantly induced only at the highest TCDD dose , but marked induction of AHH and 7 ECD was apparent when the animals were treated with 0 . 01 microgram / kg / week ; a clear dose response relationship was present in the induction at the 2 lower doses ( 0 . 01 and 0 . 10 microgram / kg / week ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Thus , the CO , O 2 and NO bound forms of cytochrome P 450cam , which have two pi type axial ligands , showed the smallest alpha MCD bands ( [ theta ] M = 5 . 2 7 . 5 ) among complexes , while ferrous cytochrome b 5 and cytochrome c , which have two sigma electron donating axial ligands , showed the largest magnitude ( [ theta ] M = 120 176 ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The rotenone insensitive NADH cytochrome c reductase activity and cytochrome b 5 content in mitochondria and microsomes of liver of 1 , 3 , 12 and 24 month old rats were studied . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Since this portion of the globin peptide chain can be structurally superimposed onto the cytochrome c and cytochrome b 5 chains ( Argos and Rossmann 1979 ) , it can be inferred that the cytochrome c gene will contain only one coding sequence while the cytochrome b 5 gene will be composed of three exons as found in the globin gene . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| DTD enzyme activities were measured in tumour extracts using 2 , 6 dichlorophenolindophenol ( DCPIP ) and NADH as substrates ; cytochrome P 450 reductase or cytochrome b 5 reductase activities were assessed with cytochrome c and NADPH or NADH respectively . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Thermodynamic characterization of the interaction between cytochrome b 5 and cytochrome c . ^^^ One of the best studies protein protein complexes has been the cytochrome b 5 and cytochrome c electron transfer pair . ^^^ We report here the use of Isothermal Titration Calorimetry to characterize the association of Rat cytochrome b 5 and Horse cytochrome c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Of the enzyme activities integrated in the microsomal electron transport chains , NADH cytochrome b 5 reductase was not affected by fibrate treatment , NADPH cytochrome c reductase activity was enhanced ( BFB = GFB > CFB ) , whereas NADH cytochrome c reductase activity was reduced by CFB and BFB . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Interpretation of these results has been facilitated through the use of energy minimization calculations to refine the hypothetical models previously suggested for the cytochrome c cytochrome b 5 precursor complex on the basis of Brownian dynamics simulations of the bimolecular encounter event . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Acute ( 165 mg / kg , 1 day ) and subacute ( 55 mg / kg , 3 days ) administration of fenitrothion caused a significant decrease on testicular cytochrome P 450 content ( 51 and 50 % respectively ) but no modification on cytochrome b 5 and NADPH cytochrome c reductase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The in vitro complexes formed between cytochrome b 5 and other proteins ( e . g . cytochrome c ) have served as a useful means to probe electrostatic contributions to macromolecular recognition . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome c was reduced in the presence of reductase plus cytochrome b 5 , and this was inhibited by the anti b 5 IgG . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Although oral administration of a methanolic extract of this plant root ( 50 , 100 or 150 mg / kg for 4 , 8 or 12 weeks ) has been found to have very little or no effect on hepatic microsomal cytochrome P 450 and cytochrome b 5 contents as well as NADPH cytochrome c reductase activity , it afforded a marked induction of uridine diphosphoglucuronyl transferase activities of liver microsomes . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| No significant changes in the components of the electron transport chain of cytochrome P 450 were established the content of cytochrome P 450 , cytochrome b 5 and cytochrome C reductase , both after 5 and 14 day mopyridone administration . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Activities of DT diaphorase , cytochrome P 450 and cytochrome b 5 reductase were determined spectrophotometrically by following the reduction of cytochrome c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| BC treatment either before initiation , during initiation and selection / promotion phases of hepatocarcinogenesis have been found to be effective in elevating hepatic microsomal cytochrome b 5 ( 24 50 % ) , P 450 ( 18 38 . 5 % ) , NADPH cytochrome c reductase ( 17 . 5 43 . 25 % ) and cytosolic aryl hydrocarbon hydroxylase ( 60 . 5 63 . 5 % ) activity to a statistically significant level measured either in the hyperplastic nodule ( HN ) or in the non nodular surrounding liver parenchyma ( NNSP ) compared to carcinogen control . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| We have analyzed the stability of the cytochrome c cytochrome b 5 and cytochrome c cytochrome c oxidase complexes as a function of solvent stress . ^^^ Glycerol promotes complex formation between cytochrome c and cytochrome b 5 but inhibits that between cytochrome c and cytochrome c oxidase . ^^^ The results with cytochrome b 5 and cytochrome c were expected ; the association of this complex is largely entropy driven . ^^^ Our interpretation is that the cytochrome c cytochrome b 5 complex excludes water . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The reductase also readily transfers electrons from NADH to ferricyanide ( Km 56 microM ) , 2 , 6 dichlorophenolindophenol ( Km 65 microM ) and cytochrome c via cytochrome b 5 but not to menadione . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Laser flash photolysis studies of electron transfer to the cytochrome b 5 cytochrome c complex . ^^^ Rate constants for electron transfer in the complex between recombinant rat mitochondrial outer membrane cytochrome b 5 or the tryptic fragment of bovine liver cytochrome b 5 and horse mitochondrial cytochrome c were measured by laser flash photolysis of 5 deazariboflavin EDTA solutions . ^^^ When an excess of cytochrome b 5 was titrated with increasing amounts of cytochrome c at low ionic strength and electron transfer was initiated by a laser flash , both proteins were rapidly reduced by deazariboflavin semiquinone . ^^^ The initial photoreduction was followed by a slower second order reduction of b 5 complexed oxidized cytochrome c by free reduced cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Intracomplex electron transfer between ruthenium 65 cytochrome b 5 and position 82 variants of yeast iso 1 cytochrome c . ^^^ We tested the idea that the aromatic ring on the invariant residue Phe 82 in cytochrome c acts as an electron transfer bridge between cytochrome c and cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Seven days later , significant increases in maternal and foetal cytochrome P 450 , cytochrome b 5 and cytochrome c ( P 450 ) reductase were found . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In microsomal enzyme assay , NADPH cytochrome c reductase activity was significantly increased , however , cytochrome P 450 , cytochrome b 5 levels , aminopyrine N demethylase and benzo [ a ] pyrene hydroxylase activities were not significantly increased in the livers of rats fed 1 . 0 or 5 . 0 % MBEBP for 4 weeks . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| PC and PG liposomes were also treated with PLA 2 in the presence of a number of proteins such as cytochrome c , cytochrome b 5 , cytochrome P 450 , polylysine , and histone H 1 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Heteronuclear filtered NMR spectra of samples containing 15N labelled cytochrome b 5 in complex with unlabelled cytochrome c allowed unambiguous assessment of pseudocontact shifts relative to diamagnetic reference states . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| This treatment caused significant increases in both material and neonatal hepatic cytochrome P 450 , cytochrome b 5 , and cytochrome c ( P 450 ) reductase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Electrochemical measurement of second order electron transfer rate constants for the reaction between cytochrome b 5 and cytochrome c . ^^^ The second order electron transfer reaction between cytochrome b 5 and cytochrome c has been studied by cyclic voltammetry utilizing a gold electrode modified with beta mercaptopropionate . ^^^ When cyclic voltammetry is performed on a solution containing a mixture of cytochrome b 5 , cytochrome c and polylysine , cytochrome b 5 undergoes reversible electrochemistry at the electrode surface while cytochrome c discriminates against the electrode surface . ^^^ The selectivity of the modified electrode for negatively charged proteins makes it possible to selectively reduce a protein possessing a net negative charge and a relatively low reduction potential ( outer mitochondrial membrane cytochrome b 5 , Eo = 102 mV ; microsomal cytochrome b 5 , Eo = 3 mV ) in the presence of another protein possessing a net positive charge and a relatively high reduction potential ( cytochrome c , Eo = 265 mV ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| PB did not affect the hepatic content of cytochrome b 5 and the activity of NADPH cytochrome c reductase , whereas it decreased the activity of NADH cytochrome c reductase in the rhesus monkeys . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Experimental and theoretical analysis of the interaction between cytochrome c and cytochrome b 5 . ^^^ Experimental and theoretical investigation of the interaction of cytochrome c and cytochrome b 5 performed over nearly twenty years has produced considerable insight into the manner in which these proteins recognize and bind to each other . ^^^ The current review provides a comprehensive summary and critical evaluation of the literature on which the current status of our understanding of the interaction of cytochrome c and cytochrome b 5 is based . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Electron transfer from cytochrome b 5 to cytochrome c . ^^^ The reaction of cytochrome b 5 with cytochrome c has become a very prominent system for investigating fundamental questions regarding interprotein electron transfer . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| C NMR spectroscopic and 10 ray crystallographic study of the role played by mitochondrial cytochrome b 5 heme propionates in the electrostatic binding to cytochrome c . ^^^ The role played by the outer mitochondrial membrane ( OM ) cytochrome b 5 heme propionate groups in the electrostatic binding between OM cytochrome b 5 and horse heart cytochrome c was investigated by 13C NMR spectroscopy and 10 ray crystallography . ^^^ Titrations of [ 13C ] heme labeled OM cytochrome b 5 with horse heart cytochrome c were carried out in order to monitor the resonances arising from the heme propionate carbonyl carbons in OM cytochrome b 5 . ^^^ The results from these titrations clearly show that only the heme propionate located on the exposed heme edge in OM cytochrome b 5 participates in the electrostatic stabilization of the complex between OM cytochrome b 5 and horse heart cytochrome c . ^^^ The similarity between the two structures , combined with the findings that only the heme propionate located on the exposed heme edge of OM cytochrome b 5 participates in the electrostatic binding to cytochrome c and that the stability of this complex is similar to that measured for the association between microsomal cytochrome b 5 and cytochrome c , clearly indicates that the site of interaction on OM cytochrome b 5 is almost identical to the one elucidated for microsomal cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Treatment with 6 MFA , 100 mg / kg / day , ip for 1 5 days to adult rats inhibited significantly the different indices of MFO system , viz . hepatic cytochrome P 450 , cytochrome b 5 content , cytochrome c reductase , aminopyrine N demethylase and acetanilide hydroxylase activities . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Groups of female Sprague Dawley rats were orally administered pantoprazole and other proton pump inhibitors , omeprazole and lansoprazole , at 5 , 50 , or 300 mg / kg / day for 7 days , followed by assays to detect changes in the levels of liver microsomal protein , cytochrome P 450 , cytochrome b 5 , NADPH cytochrome c reductase , and drug metabolizing enzyme activities . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| It is assumed that ( 1 ) hypotonic treatment or digitonin causes disruption of the outer mitochondrial membrane , and , as a consequence , desorption of the membrane bound cytochrome c in a Mg2+ dependent fashion ; ( 2 ) incubation in isotonic KCI without Mg2+ results in swelling of mitochondrial matrix , disruption of the outer membrane and cytochrome c desorption whereas Mg2+ lowers the K+ permeability of the inner membrane and , hence , prevents swelling ; ( 3 ) desorbed cytochrome c is reduced by added NADH via NADH cytochrome b 5 reductase and cytochrome b 5 or by ascorbate and is oxidized by cytochrome oxidase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In contrast , extramitochondrial cytochrome c does not stimulate respiration in permeabilized control cells , and catalyzes only a low rate of oxygen consumption via electron transfer to cytochrome b 5 on the outer mitochondrial membrane . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Cytochrome P 450 , cytochrome b 5 , four mixed functional oxidase ( MFO ) activities ( microsomal aniline hydroxylase , p nitroanisole O demethylase , aminopyrine N demethylase and NADPH cytochrome c reductase ) and glutathione levels were measured in unhepatectomized rats ( control group ) and in hepatectomized rats 12 h , 24 h , 3 days and 6 days after 70 % hepatectomy . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In both , PB and 3 MC treatment , the magnitude of increase in microsomal protein content , cytochrome b 5 and aminopyrine N demethylase ( APND ) activity was less in FR animals than in ad libitum fed ; while cytochrome P 450 levels and activities of cytochrome c reductase and acetanilide hydroxylase ( ACOH ) were higher in FR animals . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Only the higher concentrations of the fungicide ( 2 . 5 and 0 . 25 mM ) elicited a sharp decline in cytochrome P 450 , cytochrome b 5 and total sulphydryl groups content as well as in the activities of NADPH cytochrome c reductase , aminopyrine N demethylase and aniline 4 hydroxylase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Levels of the major bioreductive enzymes ( DT diaphorase , cytochrome P 450 reductase and cytochrome b 5 reductase ) were measured in tumours using cytochrome c reduction and menadione as the intermediate electron acceptor . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The reductively dimethylated derivatives of horse and yeast iso 1 ferricytochromes c have been prepared and characterized for use as NMR probes of the complexes formed by cytochrome c with bovine liver cytochrome b 5 and yeast cytochrome c peroxidase . ^^^ Two dimensional 1H 13C NMR spectroscopy of the complexes formed by the derivatized cytochromes with cytochrome b 5 and cytochrome c peroxidase has been used to investigate the number and identity of lysine residues of cytochrome c that are involved in interprotein interactions of cytochrome c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The ability of the purified b 5 1 and b 5 2 fractions to transfer the electrons from NADH cytochrome b 5 reductase to cytochrome c was investigated . ^^^ In addition , cytochrome b 5 1 was found to be more sensitive to heat treatment than b 5 2 when cytochromes were subjected to 62 degrees C for varying periods of time and the coupling of b 5 reduction to cytochrome c reduction was determined . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NMR studies of the association of cytochrome b 5 with cytochrome c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The levels of cytochrome P 450 , cytochrome b 5 , cytochrome b 5 reductase , cytochrome c reductase , hydroxyl radical , and hydrogen peroxide formation significantly increased in the Stg treated rat liver microsomes . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The ability of the purified sheep liver cytochrome b 5 to transfer electrons from NADH cytochrome b 5 reductase to cytochrome c was investigated . ^^^ The K ( m ) and Vmax values were calculated to be 0 . 088 microM cytochrome b 5 and 315 . 8 microM cytochrome c reduced / min / mg enzyme , respectively . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Following the identification of 23 of these spots by either amino acid compositional analysis or peptide mass fingerprinting or a combination of both , we confirm that many of the proteins whose expression is altered following ventricular pacing are associated with the mitochondria and energy production within the cardiomyocyte , including creatine kinase M , triosephosphate isomerase , phosphoglycerate mutase , cytochrome c oxidase , cytochrome b 5 , hydroxymethyl glutaryl CoA synthase , myoglobin , and 3 , 2 trans enoyl CoA transferase . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Unequivocal determination of metal atom oxidation state in naked heme proteins : Fe ( 3 ) myoglobin , Fe ( 3 ) cytochrome c , Fe ( 3 ) cytochrome b 5 , and Fe ( 3 ) cytochrome b 5 L47R . ^^^ The ion atom oxidation state is determined unequivocally as Fe ( 3 ) for each of four gas phase unhydrated heme proteins electrosprayed from H2O : myoglobin , cytochrome c , cytochrome b 5 , and cytochrome b 5 L47R ( i . e . , the solution phase oxidation state is conserved following electrospray to produce gas phase ions ) . ^^^ Finally , infrared multiphoton irradiation of the gas phase Fe ( 3 ) holoproteins releases Fe ( 3 ) heme from each of the noncovalently bound Fe ( 3 ) heme proteins ( myoglobin , cytochrome b 5 and cytochrome b 5 L47R ) , but yields Fe ( 2 ) heme from the covalently bound heme in cytochrome c . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Spectral analyses of key coenzymes of renal cytochrome P 450 monooxygenase , cytochrome b 5 and cytochrome c reductase , demonstrated an inhibition when incubated with high concentrations of propofol ( P < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| In male rats , P 450 and cytochrome b 5 ( b 5 ) contents , and NADPH cytochrome c reductase ( fp 2 ) activity in liver microsomes were increased about 2 fold by 1 % terbutol administration for 7 to 28 days . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Tandem mass spectrometry of protein protein complexes : cytochrome c cytochrome b 5 . ^^^ An improved method to interpret triple quadrupole MS / MS experiments of complexes of large ions is presented and applied to a study of the complex formed by the proteins cytochrome c and cytochrome b 5 . ^^^ Complexes of cytochrome c and cytochrome b 5 are detected in ESI mass spectra but with abundances less than expected from the solution equilibrium . ^^^ Dissociation of the cytochrome c cytochrome b 5 complexes with charge k gives as the most abundant fragments , cytochrome b 5 ( +3 ) and cytochrome c+ ( k 3 ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| One hour after acute exposures to such conditions , the activities of hepatic cytochrome P 450 , cytochrome b 5 and NADPH cytochrome c reductase were significantly decreased in the induced animal model . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Levels of CYP 450 , cytochrome b 5 and NADPH cytochrome c reductase activity did not show differences among groups . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| All 25 currently identified type 1 and type 2 methemoglobinemia mutants have been expressed in Escherichia coli using a novel six histidine tagged rat cytochrome b5 / cytochrome b 5 reductase fusion protein designated NADH : cytochrome c reductase ( H6NCR ) . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| A further investigation of the cytochrome b 5 cytochrome c complex . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Both drugs produced significant decrease in the activity of NADH : cytochrome c oxidoreductase in rats exposed to 21 degrees C , but not to 28 degrees C and 35 degrees C , and did not change the activity of aniline hydroxylase , aminopyrine N demethylase and 4 nitroanisole O demethylase and cytochrome b 5 level at any tested temperatures . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Mapping the binding interface of the cytochrome b 5 cytochrome c complex by nuclear magnetic resonance . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Mapping the electron transfer interface between cytochrome b 5 and cytochrome c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The data obtained show that rats have higher hepato somatic index , specific cytochrome b 5 concentration , and NADPH dependent cytochrome c ( P 450 ) activity compared to ectothermic species , SOD activity similar to those in amphibians , and specific concentration of cytochrome P 450 and catalase activity lower than in a toad , but higher than in fishes and a frog . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The orientations of cytochrome c in the highly dynamic complex with cytochrome b 5 visualized by NMR and docking using HADDOCK . ^^^ Protein protein docking simulations have been performed for the binary cytochrome b 5 cytochrome c and ternary ( cytochrome b 5 ) ( cytochrome c ) 2 complexes using a novel HADDOCK approach . ^^^ It is demonstrated that cytochrome c uses a confined surface patch for interaction with a much more extensive surface area of cytochrome b 5 . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Various spectrophotometric assays have been performed to examine electron accepting properties of CPR and its ability to reduce cytochrome b 5 , cytochrome c , and ferricyanide . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The main components ( total CYP and cytochrome b 5 ; NADPH dependent cytochrome c ( CYP ) reductase , NADH dependent cytochrome c reductase and NADH dependent ferricyanide ( b 5 ) reductase activities ) were found in most species of the Porifera , Cnidaria , Mollusca , Polychaeta , Crustacea and Echinodermata examined . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| For haemoproteins with reduction potentials more positive than 160 mV , such as chloroperoxidase , cytochrome b 5 , methaemoglobin and cytochrome c , there was a good correlation between the second order reduction rate constant and the redox potential , E ( m ) ( Fe ( 3 ) / Fe ( 2 ) ) : [ formula : see text ] . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| Characterization and calculation of a cytochrome c cytochrome b 5 complex using NMR data . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| A cytosolic cytochrome b 5 like protein in yeast cell accelerating the electron transfer from NADPH to cytochrome c catalyzed by Old Yellow Enzyme . ^^^ The cytochrome b 5 like protein enhanced the reduction rate of cytochrome c by OYE , and a plot of the reduction rates against its concentration showed a sigmoidal curve with an inflexion point at 6x10 ( 8 ) M of the protein . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| These proteo dendrimer receptors exhibited higher affinities with cytochrome c proteins in aqueous solutions than with biological cytochrome b 5 . ^^^ Furthermore , they effectively blocked complexation of biological cytochrome b 5 with cytochrome c , indicating that the proteo dendrimers and cytochrome b 5 similarly occupy the polycationic patch of cytochrome c . . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| The reaction of neuroglobin with potential redox protein partners cytochrome b 5 and cytochrome c . ^^^ |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and P99999 |
Pubmed |
SVM Score :0.0 |
| NA |
|