Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
Lymphocyte samples were simultaneously thawed , phytohemagglutinin activated , and analyzed for benz ( a ) anthracene induced aryl hydrocarbon hydroxylase ( AHH ) levels , [ 3H ] thymidine incorporation , and reduced nicotinamide adenine dinucleotide dependent cytochrome b 5 ( cytochrome c ) reductase activity . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
P 450 ) , cytochrome b 5 ( Cyt . b 5 ) , aryl hydrocarbon hydroxylase ( AHH ) , glutathione S transferase ( GST ) , DT diaphorase ( DTD ) , acid soluble sulfhydryl ( SH ) content and radiation induced malondialdehyde ( MDA ) formation were recorded . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
Animals sacrificed 72 h after a single intraparenteral dose of argemone oil exhibited a significant loss of hepatic cytochrome P 450 ( 35 % ) and cytochrome b 5 ( 34 % ) contents and inhibition of aminopyrine N demethylase ( APD ) , aryl hydrocarbon hydroxylase ( AHH ) and ethoxycoumarin O deethylase ( ECD ) activities ( 21 39 % ) . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
Pretreatment with 7 , 8 BF increased both P 450 and cytochrome b 5 levels , whereas phenobarbital ( PB ) and 3 methylcholanthrene ( MC ) induced P 450 but not cytochrome b 5 . 7 , 8 BF pretreatment increased 7 ethoxyresorufin O deethylase ( EROD ) 3 fold and 7 pentoxyresorufin O dealkylase ( PROD ) 2 . 5 fold , whereas aromatic hydrocarbon hydroxylase ( AHH ) and 7 ethoxycoumarin O deethylase ( ECOD ) activities were only slightly induced by 7 , 8 BF . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
Treatment of guinea pigs on adequate ascorbic acid ( AA ) with 20 methylcholanthrene ( MCA ) and phenobarbital ( PB ) significantly increased hepatic arylhydrocarbon hydroxylase ( AHH ) , cytochrome P 450 and cytochrome b 5 activities . ^^^ In lungs , only MCA treatment significantly enhanced the activities of AHH , cytochrome P 450 and cytochrome b 5 . ^^^ In animals on excessive doses of AA , there was inhibition of hepatic AHH , cytochrome P 450 and cytochrome b 5 levels by treatment with these xenobiotics . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
Both P 450 ALC and P 450 C effectively demethylate N nitrosodimethylamine ( NDMA ) at low substrate concentrations ( 0 . 5 mM ) , especially in the presence of cytochrome b 5 . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
The activities of microsomal aryl hydrocarbon hydroxylase ( AHH ) , aminopyrine demethylase , NADPH cytochrome c reductase , epoxide hydrolase , cytosolic glutathione S transferase as well as the concentrations of cytochrome P 450 and cytochrome b 5 were determined . ^^^ The activity of NADPH cytochrome c reductase and the content of cytochrome b 5 were enhanced by o toluidine only in the liver . m Toluidine enhanced the glutathione S transferase activity while the p isomer increased both the epoxide hydrolase and the glutathione S transferase activities . p Toluidine decreased the AHH and aminopyrine demethylase activities and the cytochrome P 450 content . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
Cytochrome b 5 and cytochrome c reductase were unaffected at any of the dose levels and cytochrome P 450 was significantly induced only at the highest TCDD dose , but marked induction of AHH and 7 ECD was apparent when the animals were treated with 0 . 01 microgram / kg / week ; a clear dose response relationship was present in the induction at the 2 lower doses ( 0 . 01 and 0 . 10 microgram / kg / week ) . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
These results demonstrate that cytochrome b 5 is involved in fatty acyl CoA desaturase activities and in certain cytochrome P 450 monooxygenase activities ( i . e . , MCOD , ECOD , and AHH ) in LPR house fly microsomes . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
In comparison to the aabys strain , LPR had higher levels of total cytochromes P 450 , cytochrome b 5 , P 450 reductase , CYP6D1 , and three P 450 monooxygenase activities : 7 ethoxycoumarin O deethylase ( ECOD ) , methoxyresorufin O demethylase ( MROD ) , and aromatic hydrocarbon hydroxylase ( AHH ) . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
The bioactivation of N nitrosoamines and polycyclic aromatic hydrocarbons ( PAH ) is mediated by the mixed function oxidase system , which includes dimethylnitrosamine N demethylase 1 ( DMN dI ) , arylhydrocarbon hydroxylase ( AHH ) , cytochrome P 450 , cytochrome b 5 and NADPH cytochrome c reductase of liver microsomes . ^^^ Single dose treatment ( 20 mg / kg body weight ) of male mice with ethylbutylnitrosamine , propylbutylnitrosamine , or dibutylnitrosamine : increased ( 1 ) the activity of DMN dI by 108 % , 104 % , 51 % , respectively ; ( 2 ) the cytochrome P 450 content by 106 % , 72 % , 51 % , respectively ; ( 3 ) the activity of AHH by 95 % , 106 % , 80 % respectively ; ( 4 ) the cytochrome b 5 content by 164 % , 97 % , 94 % respectively ; and ( 5 ) decreased the activity of NADPH cytochrome c reductase by 55 % , 50 % and 45 % , respectively . ^^^ Diphenylnitrosamine also decreased cytochrome P 450 by 54 % , AHH activity by 64 % but increased the activity of DMN dI by 42 % , the cytochrome b 5 content by 159 % and NADPH cytochrome c reductase activity by 57 % . ^^^ Also , the extent to which the altered activities of DMN dI , P 450 , AHH , cytochrome b 5 and NADPH cytochrome c reductase depends on the type of alkyl groups linked to the nitroso group . . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
Involvement of cytochrome b 5 in the metabolism of tetrachlorobiphenyls catalyzed by CYP2B1 and CYP1A1 . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
This treatment also results in increases in NADPH cytochrome P 450 reductase and P glycoprotein ( the MDR 1 gene product ) but has no detectable effect on expression of CYP1A1 , CYP2D6 , cytochrome b 5 , liver or intestinal fatty acid binding proteins , or villin . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
The mixed function oxidase system includes the phase 1 drug oxidation proteins e . g . aryl hydrocarbon hydroxylase ( AHH ) , N nitrosodimethylamine N demethylase 1 ( NDMA dI ) and cytochrome b 5 which metabolize most carcinogens and xenobiotics into less and / or more active intermediates . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
The present study was under taken to demonstrate the effect of some commonly used insecticides on the activity of cytochrome P 450 system including cytochrome b 5 , aryl hydrocarbon [ benzo ( a ) pyrene ] hydroxylase ( AHH ) , N nirosodimethylamine N demethylase 1 [ NDMA dI ] and NADPH cytochrome c reductase as phase 1 of drug oxidation . ^^^ In addition , single and repeated dose treatments of mice with lindane induced : ( 1 ) cytochrome P 450 by 23 and 65 % , respectively , ( 2 ) cytochrome b 5 by 49 and 131 % , respectively , ( 3 ) AHH activity by 64 and 50 % , respectively . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
The role of cytochrome b 5 in the cytochrome P 450 dependent hydroxylation of tetrachlorobiphenyl ( TCB ) isomers was examined using a reconstituted system consisting of CYP2B1 and CYP1A1 and rat liver microsomes . 2 . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
This dose markedly increased the hepatic contents of cytochrome P 450 and cytochrome b 5 and activities of NADPH cytochrome c reductase and aryl hydrocarbon hydroxylase ( AHH ) . ^^^
Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P00167 and P04798 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
Both P 450 ALC and P 450 C effectively demethylate N nitrosodimethylamine ( NDMA ) at low substrate concentrations ( 0 . 5 mM ) , especially in the presence of cytochrome b 5 . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
P 450 ) , cytochrome b 5 ( Cyt . b 5 ) , aryl hydrocarbon hydroxylase ( AHH ) , glutathione S transferase ( GST ) , DT diaphorase ( DTD ) , acid soluble sulfhydryl ( SH ) content and radiation induced malondialdehyde ( MDA ) formation were recorded . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
Animals sacrificed 72 h after a single intraparenteral dose of argemone oil exhibited a significant loss of hepatic cytochrome P 450 ( 35 % ) and cytochrome b 5 ( 34 % ) contents and inhibition of aminopyrine N demethylase ( APD ) , aryl hydrocarbon hydroxylase ( AHH ) and ethoxycoumarin O deethylase ( ECD ) activities ( 21 39 % ) . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
Pretreatment with 7 , 8 BF increased both P 450 and cytochrome b 5 levels , whereas phenobarbital ( PB ) and 3 methylcholanthrene ( MC ) induced P 450 but not cytochrome b 5 . 7 , 8 BF pretreatment increased 7 ethoxyresorufin O deethylase ( EROD ) 3 fold and 7 pentoxyresorufin O dealkylase ( PROD ) 2 . 5 fold , whereas aromatic hydrocarbon hydroxylase ( AHH ) and 7 ethoxycoumarin O deethylase ( ECOD ) activities were only slightly induced by 7 , 8 BF . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
Treatment of guinea pigs on adequate ascorbic acid ( AA ) with 20 methylcholanthrene ( MCA ) and phenobarbital ( PB ) significantly increased hepatic arylhydrocarbon hydroxylase ( AHH ) , cytochrome P 450 and cytochrome b 5 activities . ^^^ In lungs , only MCA treatment significantly enhanced the activities of AHH , cytochrome P 450 and cytochrome b 5 . ^^^ In animals on excessive doses of AA , there was inhibition of hepatic AHH , cytochrome P 450 and cytochrome b 5 levels by treatment with these xenobiotics . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
Lymphocyte samples were simultaneously thawed , phytohemagglutinin activated , and analyzed for benz ( a ) anthracene induced aryl hydrocarbon hydroxylase ( AHH ) levels , [ 3H ] thymidine incorporation , and reduced nicotinamide adenine dinucleotide dependent cytochrome b 5 ( cytochrome c ) reductase activity . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
The activities of microsomal aryl hydrocarbon hydroxylase ( AHH ) , aminopyrine demethylase , NADPH cytochrome c reductase , epoxide hydrolase , cytosolic glutathione S transferase as well as the concentrations of cytochrome P 450 and cytochrome b 5 were determined . ^^^ The activity of NADPH cytochrome c reductase and the content of cytochrome b 5 were enhanced by o toluidine only in the liver . m Toluidine enhanced the glutathione S transferase activity while the p isomer increased both the epoxide hydrolase and the glutathione S transferase activities . p Toluidine decreased the AHH and aminopyrine demethylase activities and the cytochrome P 450 content . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
Cytochrome b 5 and cytochrome c reductase were unaffected at any of the dose levels and cytochrome P 450 was significantly induced only at the highest TCDD dose , but marked induction of AHH and 7 ECD was apparent when the animals were treated with 0 . 01 microgram / kg / week ; a clear dose response relationship was present in the induction at the 2 lower doses ( 0 . 01 and 0 . 10 microgram / kg / week ) . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
These results demonstrate that cytochrome b 5 is involved in fatty acyl CoA desaturase activities and in certain cytochrome P 450 monooxygenase activities ( i . e . , MCOD , ECOD , and AHH ) in LPR house fly microsomes . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
In comparison to the aabys strain , LPR had higher levels of total cytochromes P 450 , cytochrome b 5 , P 450 reductase , CYP6D1 , and three P 450 monooxygenase activities : 7 ethoxycoumarin O deethylase ( ECOD ) , methoxyresorufin O demethylase ( MROD ) , and aromatic hydrocarbon hydroxylase ( AHH ) . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
The bioactivation of N nitrosoamines and polycyclic aromatic hydrocarbons ( PAH ) is mediated by the mixed function oxidase system , which includes dimethylnitrosamine N demethylase 1 ( DMN dI ) , arylhydrocarbon hydroxylase ( AHH ) , cytochrome P 450 , cytochrome b 5 and NADPH cytochrome c reductase of liver microsomes . ^^^ Single dose treatment ( 20 mg / kg body weight ) of male mice with ethylbutylnitrosamine , propylbutylnitrosamine , or dibutylnitrosamine : increased ( 1 ) the activity of DMN dI by 108 % , 104 % , 51 % , respectively ; ( 2 ) the cytochrome P 450 content by 106 % , 72 % , 51 % , respectively ; ( 3 ) the activity of AHH by 95 % , 106 % , 80 % respectively ; ( 4 ) the cytochrome b 5 content by 164 % , 97 % , 94 % respectively ; and ( 5 ) decreased the activity of NADPH cytochrome c reductase by 55 % , 50 % and 45 % , respectively . ^^^ Diphenylnitrosamine also decreased cytochrome P 450 by 54 % , AHH activity by 64 % but increased the activity of DMN dI by 42 % , the cytochrome b 5 content by 159 % and NADPH cytochrome c reductase activity by 57 % . ^^^ Also , the extent to which the altered activities of DMN dI , P 450 , AHH , cytochrome b 5 and NADPH cytochrome c reductase depends on the type of alkyl groups linked to the nitroso group . . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
This dose markedly increased the hepatic contents of cytochrome P 450 and cytochrome b 5 and activities of NADPH cytochrome c reductase and aryl hydrocarbon hydroxylase ( AHH ) . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
Involvement of cytochrome b 5 in the metabolism of tetrachlorobiphenyls catalyzed by CYP2B1 and CYP1A1 . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
This treatment also results in increases in NADPH cytochrome P 450 reductase and P glycoprotein ( the MDR 1 gene product ) but has no detectable effect on expression of CYP1A1 , CYP2D6 , cytochrome b 5 , liver or intestinal fatty acid binding proteins , or villin . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
The role of cytochrome b 5 in the cytochrome P 450 dependent hydroxylation of tetrachlorobiphenyl ( TCB ) isomers was examined using a reconstituted system consisting of CYP2B1 and CYP1A1 and rat liver microsomes . 2 . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
The mixed function oxidase system includes the phase 1 drug oxidation proteins e . g . aryl hydrocarbon hydroxylase ( AHH ) , N nitrosodimethylamine N demethylase 1 ( NDMA dI ) and cytochrome b 5 which metabolize most carcinogens and xenobiotics into less and / or more active intermediates . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
The present study was under taken to demonstrate the effect of some commonly used insecticides on the activity of cytochrome P 450 system including cytochrome b 5 , aryl hydrocarbon [ benzo ( a ) pyrene ] hydroxylase ( AHH ) , N nirosodimethylamine N demethylase 1 [ NDMA dI ] and NADPH cytochrome c reductase as phase 1 of drug oxidation . ^^^ In addition , single and repeated dose treatments of mice with lindane induced : ( 1 ) cytochrome P 450 by 23 and 65 % , respectively , ( 2 ) cytochrome b 5 by 49 and 131 % , respectively , ( 3 ) AHH activity by 64 and 50 % , respectively . ^^^
Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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Interacting proteins: P04798 and P00167 Pubmed SVM Score :0.0
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