| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| The NADH dependent stearoyl CoA desaturase of hepatic microsomes ( EC 1 . 14 . 99 . 5 ) is an enzyme system consisting of cytochrome b 5 reductase ( EC 1 . 6 . 2 . 2 ) , cytochrome b 5 , and the terminal desaturase . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| From amino acid analyses , a comparison was made of the hydrophobicity of the membrane portion of cytochrome b 5 with the hydrophobicity reported for stearoyl CoA desaturase . ^^^ The close resemblance of the two values suggested that unlike cytochrome b 5 and its reductase , the stearoyl CoA desaturase may be largely buried in the endoplasmic reticulum . . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| The treatment of ZD rats with Cd reduced the activity of liver microsomal stearoyl CoA desaturase by 90 % without any changes in the activity of NADH cytochrome b 5 reductase or in the microsomal level of cytochrome b 5 whereas the activity of stearoyl CoA desaturase was reduced by only 35 % by the treatment of ZA rats with Cd . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| This suggests that it is not the activated beta ketoreductase which stimulates the cytochrome b 5 reoxidation rate , but another electron acceptor . ( b ) The delta 9 desaturase , present in microsomes from rats fed a fat free diet , was totally inhibited by 4 mM KCN ; beta ketopalmitoyl CoA or malonyl CoA stimulated the reoxidation rate of cytochrome b 5 but this increase was also inhibited by 4 mM KCN . ^^^ This suggests that delta 9 desaturase is involved in the stimulation and shows that any inhibitor of delta 9 desaturase , including cytochrome b 5 antibodies , may induce elongation inhibition . ( c ) NADH dependent beta ketoreductase activity was partially purified from Triton 10 100 solubilised microsomes , in a fraction essentially free of cytochrome b 5 . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| The increase in stearoyl CoA desaturase activity by peroxisome proliferators was not accompanied by any notable increases in the microsomal content of cytochrome b 5 or the activity of NADH : cytochrome b 5 reductase . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| In contrast , reductions in the amount of cytochrome b 5 and the NADH supported rate of stearoyl CoA desaturase were observed . ^^^ These data suggest that decreased stearoyl CoA desaturase activity is the result of lowered cytochrome b 5 levels in microsomes isolated from ethanol consuming hamsters . . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| Preincubation of the mammary microsomes with purified terminal desaturase gives a 55 fold stimulation of stearoyl CoA desaturase activity , whereas preincubation with cytochrome b 5 has no effect . ^^^ These observations suggest that negligible stearoyl CoA desaturase activity in lactating rat mammary microsomes is due to a cytochrome b 5 content and the absence of terminal enzyme . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| In this study it was found that the 14CO2 formation from the 14C labeled lanosterol was inhibited by antibodies to yeast cytochrome b 5 and by palmitoyl CoA , a substrate of the cytochrome b 5 containing fatty acyl CoA desaturase system of yeast microsomes . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate that cytochrome b 5 is involved in fatty acyl CoA desaturase activities and in certain cytochrome P 450 monooxygenase activities ( i . e . , MCOD , ECOD , and AHH ) in LPR house fly microsomes . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| A novel cytochrome b 5 like domain is linked to the carboxyl terminus of the Saccharomyces cerevisiae delta 9 fatty acid desaturase . ^^^ Although the yeast delta 9 fatty acid desaturase does not appear to require cytochrome b 5 , introduction of the rat liver stearoyl CoA desaturase gene into an ole 1 disrupted , cytochrome b 5 disrupted yeast strain revealed that this enzyme specifically requires cytochrome b 5 to function . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| Cloning and expression of the delta 9 fatty acid desaturase gene from Cryptococcus curvatus ATCC 20509 containing histidine boxes and a cytochrome b 5 domain . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| Molecular oxygen is required for enzymatic activity , and cyanide , divalent copper , as well as antibodies raised against cytochrome b 5 are inhibitory , which suggests that this enzyme should be named dihydroceramide desaturase based on these similarities with the mechanism of delta 9 desaturase ( stearoyl CoA desaturase ) . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| The b 5 core domain shows a 52 % identity and 70 % similarity to that of the yeast microsomal cytochrome b 5 and a 35 % identity and 54 % similarity to the b 5 core domain of OLE 1 , the S . cerevisiae Delta 9 fatty acid desaturase . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| Delta 9 fatty acid desaturase gene containing a carboxyl terminal cytochrome b 5 domain from the red alga Cyanidioschyzon merolae . ^^^ CmFad9p is a unique delta 9 fatty acid desaturase among plants , in that it is fused with the cytochrome b 5 domain at its carboxyl terminus . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| The cytochrome b 5 genes were not induced at 6 degrees C and their response to ABA was relatively slow compared with fatty acid desaturase genes . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| Histidine 41 of the cytochrome b 5 domain of the borage delta 6 fatty acid desaturase is essential for enzyme activity . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| This desaturase is a novel member of the cytochrome b 5 containing Delta 5 fatty acid desaturase . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| These genes are alpha 1 protease inhibitor , cytochrome b 5 , stearoyl CoA desaturase and carboxylesterase . ^^^ Stearoyl CoA desaturase , cytochrome b 5 and carboxylesterase are endoplasmic reticulum membrane bound enzymes involved in fatty acid metabolism . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| The expressed sequence tag ( EST ) resource of C . reinhardtii led to the isolation of a cDNA clone that encoded a putative fatty acid desaturase named as CrDES containing a cytochrome b 5 domain at the N terminus . ^^^ |
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| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00167 and O00767 |
Pubmed |
SVM Score :0.0 |
| NA |
|