| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.73331864 |
| The receptor Tom 22 stably associates with Tom 40 , the main component of the GIP , in a complex with a molecular weight of approximately 400 , 000 ( approximately 400K ) , while the other receptors , Tom 20 and Tom 70 , are more loosely associated with this GIP complex and can be found in distinct subcomplexes . 0.73331864^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :1.346621 |
| The central receptor Tom 22 binds preproteins through both its cytosolic domain and its intermembrane space domain and is stably associated with the channel protein Tom 40 ( refs 11 13 ) . 1.346621^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.54874235 |
| Mitochondria lacking Mdm 10 are selectively impaired in the final steps of the assembly pathway of Tom 40 , including the association of Tom 40 with the receptor Tom 22 and small Tom proteins , while the biogenesis of porin is not affected . 0.54874235^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| Tom 40 is found in a high molecular weight complex termed the general import pore ( GIP ) complex where it is tightly associated with the receptor protein Tom 22 along with Tom 7 , Tom 6 and Tom 5 . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| Thus , the TOM core complex , consisting of Tom 40 , Tom 22 , Tom 6 and Tom 7 , is a molecular machine that can recognize and partially translocate mitochondrial precursor proteins . . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| In blue native PAGE , Tom 40 , Tom 22 , and a portion of Tom 20 migrated as a complex of approximately 400 kDa , and the other portion of Tom 20 migrated in smaller forms of approximately 100 and approximately 40 kDa . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| The preprotein translocase of the yeast mitochondrial outer membrane ( TOM ) consists of the initial import receptors Tom 70 and Tom 20 and a approximately 400 kDa ( 400 K ) general import pore ( GIP ) complex that includes the central receptor Tom 22 , the channel Tom 40 , and the three small Tom proteins Tom 7 , Tom 6 , and Tom 5 . ^^^ Together , Tom 40 and Tom 22 thus represent the functional core unit that stably holds accumulated preproteins . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| Moreover , the porin precursor can be cross linked to Tom 20 , Tom 22 , and Tom 40 on its import pathway . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| A lack of Tom 7 stabilized the interaction between the receptors Tom 20 and Tom 22 and the import pore component Tom 40 . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| One complex of approximately 400 kDa contains the receptor Tom 22 and the general import pore component Tom 40 , the other complex of approximately 120 kDa contains the receptor Tom 70 . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| The Tom 40 assembly is influenced by a block of negatively charged amino acid residues in the cytosolic domain of Tom 22 , indicating a cross talk between preprotein receptors and the translocation pore . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| Using IgG Sepharose affinity chromatography of solubilized zippered membranes , we have isolated a multisubunit complex that contains all Tom and Tim components known to be essential for import of matrix targeted proteins , namely Tom 40 , Tom 22 , Tim 17 , Tim 23 , Tim 44 , and matrix localized Hsp 70 . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| It consists of Tom 40 , Tom 22 , and the small Tom components , Tom 6 and Tom 7 . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| The precursor of the channel lining Tom 40 is first targeted to the membrane via the receptor proteins Tom 20 and Tom 22 ; it then assembles with Tom 5 to form the 250 kDa intermediate exposed to the intermembrane space . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| We have isolated Tom 40 of Neurospora crassa by removing the receptor Tom 22 and the small Tom components Tom 6 and Tom 7 from the purified TOM core complex . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| This translocase of the outer membrane ( TOM ) consists of three receptor proteins , Tom 20 , Tom 22 and Tom 70 , the channel protein Tom 40 , and several small Tom proteins . ^^^ From mutant mitochondria lacking Tom 22 , native electrophoresis separates an approximately 80 kDa subcomplex that consists of Tom 40 only and is functional for accumulation of a precursor protein . ^^^ We conclude that while Tom 40 forms the import channels , the two receptors Tom 22 and Tom 20 are required for the organization of Tom 40 dimers into larger TOM structures . . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| Mitochondria with reduced levels of Tom 40 were deficient for import of mitochondrial preproteins and contained reduced levels of the TOM complex components Tom 22 and Tom 6 , suggesting that the import and / or stability of these proteins is dependent on the presence of Tom 40 . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| It is then transported into the sperm mitochondria by Tom 22 and Tom 40 , where it destroys the sperm mtDNA , establishing the maternal inheritance of mtDNA . . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| In cells lacking mitochondrial DNA , Rpm2p influences the levels of TOM 40 , TOM 6 , TOM 20 , TOM 22 , and TOM 37 mRNAs , which encode components of the mitochondrial import apparatus , but not that of TOM 70 mRNA . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| This revealed that ( 1 ) Map targeting is dependent on the predicted N terminal mitochondrial targeting sequence , ( 2 ) the N terminal 44 residues are sufficient to target proteins to mitochondria and ( 3 ) Map import involves the mitochondrial outer membrane translocase ( Tom 22 and Tom 40 ) , the mitochondrial membrane potential , and the matrix chaperone , mtHsp 70 . ^^^ |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NS69 and O96008 |
Pubmed |
SVM Score :0.0 |
| NA |
|