| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.62473054 |
| By co immunoprecipitation , we found that Hct 1 interacted with the mitotic cyclins Clb 2 and Clb 3 and the polo related kinase Cdc 5 , whereas Cdc 20 interacted with the securin Pds 1 . 0.62473054^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex ( APC ) bound to Cdc 20 or Cdh 1 . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| One such APC / C substrate , the budding yeast anaphase inhibitor Pds 1 ( securin ) , is degraded prior to anaphase initiation in a destruction box and APC / C ( Cdc 20 ) dependent manner [ 3 , 7 ] . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| APC ( Cdc 20 ) promotes sister chromatid separation by ubiquitinating securin , whereas APC ( Cdh 1 ) ubiquitinates mitotic cyclins , allowing the exit from mitosis . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Recently , an additional cis element called the `` KEN box ' ' was also shown to be required for proteolysis of human CDC 20 and Securin [ 3 , 12 ] . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC / C switches from activation by Cdc 20 to Cdh 1 . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| It binds to human p55CDC and prevents it from promoting destruction of an anaphase inhibitor , securin . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| APC Cdc 20 activity during mitosis triggers anaphase by destroying securin and cyclins . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| We show that the inactivation of PKA or expression of phosphorylation defective Cdc 20 proteins accelerates securin and Clb 2 destruction in chk 1 mutants and is sufficient to remove most of the DNA damage induced delay . ^^^ These data show that PKA pathways regulate mitotic progression through Cdc 20 and support the DNA damage checkpoint pathways in regulating the destruction of Clb 2 and securin . . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Here we show that BubR 1 ( + / ) mouse embryonic fibroblasts are defective in spindle checkpoint activation , contain a significantly reduced amount of securin and Cdc 20 , and exhibit a greater level of micronuclei than do wild type cells . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Cdc 20 assists the activity of the checkpoint pathways in the inhibition of the degradation of mitotic inhibitors securin , Pds 1 , and the B type cyclin , Clb 2 , in order to block anaphase and mitotic exit . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Spo 13 is also required for the reaccumulation of securin , the persistence of centromeric cohesin during meiosis 2 , and the maintenance of a metaphase 1 arrest induced by downregulation of the APC / C activator CDC 20 . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| The APC is activated by the regulatory subunits Cdc 20 ( APC ( Cdc 20 ) ) and Cdh 1 ( APC ( Cdh 1 ) ) to target securin , mitotic cyclins and other cell cycle regulatory proteins for proteasomal degradation . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Recent experiments shed important insight into how Mad 2 molecules bound to centromeres through their association with a protein called Mad 1 might be transferred to Cdc 20 and thereby inhibit securin ' s destruction . . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Separase is activated when its inhibitor , securin , is polyubiquitinated by the Cdc 20 regulated anaphase promoting complex ( APC ( Cdc 20 ) ) and consequently degraded . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Activation of the anaphase promoting complex / cyclosome ( APC / C ) by Cdc 20 and Cdh 1 leads to ubiquitin dependent degradation of securin and cyclin B and thereby promotes the initiation of anaphase and exit from mitosis . ^^^ Cyclin B and securin ubiquitination depend on a destruction box ( D box ) sequence in these proteins , but how APC / C bound to Cdc 20 or Cdh 1 recognizes the D box is poorly understood . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Mad 2 is a pivotal component of the spindle assembly checkpoint ( SAC ) which inhibits anaphase promoting complex / cyclo some ( APC / C ) activity by sequestering Cdc 20 thereby regulating the destruction of securin and cyclin B . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Cdc 20 and Cdh 1 are the activating subunits of the anaphase promoting complex ( APC ) , an E 3 ubiquitin ligase that drives cells into anaphase by inducing degradation of cyclin B and the anaphase inhibitor securin . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| The established view is that Cdc 20 activated APC ( APC ( Cdc 20 ) ) mediates the destruction of cyclin B and securin at the metaphase / anaphase transition , and that Cdh 1 activated APC ( APC ( Cdh 1 ) ) has no role in this process . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| Cdc 20 ( cell division cycle 20 ) and Cdh 1 are the activating subunits of APC ( anaphase promoting complex ) , an E 3 ubiquitin ligase that drives cells into anaphase by inducing degradation of cyclin B and the anaphase inhibitor securin . ^^^ To prevent chromosome missegregation due to early degradation of cyclin B and securin , mitotic checkpoint protein complexes consisting of BubR 1 , Bub 3 and Mad 2 bind to and inhibit APC ( Cdc 20 ) until all chromosomes are properly attached to the mitotic spindle and aligned in the metaphase plate . ^^^ |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95997 and Q12834 |
Pubmed |
SVM Score :0.0 |
| NA |
|