| Interacting proteins: O95832 and P08253 |
Pubmed |
SVM Score :0.0 |
| Stimulation of MT MMP mediated pro MMP 2 activation was also observed with other claudin family members , claudin 1 , claudin 2 , and claudin 3 . ^^^ Direct interaction of claudin 1 with MT 1 MMP and MMP 2 was demonstrated by immunoprecipitation analysis . ^^^ TIMP 2 enhanced cell surface localization of MMP 2 mediated by MT 1 MMP , and claudin 1 also stimulated it . ^^^ |
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| Interacting proteins: O95832 and P08253 |
Pubmed |
SVM Score :0.0 |
| Tight junction protein claudin 1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin 5 gamma 2 chain via matrix metalloproteinase ( MMP ) 2 and membrane type MMP 1 . ^^^ Compared with OSC 7 , both OSC 4 and NOS 2 more strongly expressed claudin 1 and possessed high activities of MMP 2 and MMP 9 . ^^^ Claudin 1 siRNA largely suppressed the invasion of OSC 4 and decreased the activation of MMP 2 , the expression of membrane type MMP 1 ( MT 1 MMP ) , and the cleavage of laminin 5 gamma 2 . ^^^ These results suggest that claudin 1 up regulates cancer cell invasion activity through activation of MT 1 MMP and MMP 2 , which results in enhanced cleavage of laminin 5 gamma 2 chains . . ^^^ |
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