| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.52665317 |
| Next , two L transfectants singly expressing claudin 1 , 2 , or 3 were cocultured and we found that claudin 3 strands laterally associated with claudin 1 and 2 strands to form paired strands , whereas claudin 1 strands did not interact with claudin 2 strands . 0.52665317^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| C CPE bound to claudin 3 and 4 with high affinity , but not to claudin 1 or 2 . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| The peptide toxin Clostridium perfringens enterotoxin ( CPE ) has been shown to bind to claudin 3 and 4 , but not to claudin 1 or 2 . ^^^ We constructed claudin 1 / claudin 3 chimeric molecules and found that the second extracellular loop of claudin 3 conferred CPE sensitivity on L fibroblasts . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Stimulation of MT MMP mediated pro MMP 2 activation was also observed with other claudin family members , claudin 1 , claudin 2 , and claudin 3 . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence microscopic analyses of serial frozen sections of mouse kidneys with polyclonal antibodies for claudins and segment markers revealed that claudins demonstrated very complicated , segment specific , expression patterns in nephrons , i . e . , claudin 1 and 2 in Bowman ' s capsule , claudin 2 , 10 , and 11 in the proximal tubule , claudin 2 in the thin descending limb of Henle , claudin 3 , 4 , and 8 in the thin ascending limb of Henle , claudin 3 , 10 , 11 , and 16 in the thick ascending limb of Henle , claudin 3 and 8 in the distal tubule , and claudin 3 , 4 , and 8 in the collecting duct . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Occludin , claudin 1 and claudin 3 mRNAs were expressed in human neonatal and adult keratinocytes as well as in HaCaT keratinocytes . ^^^ Our results indicate that occludin , claudin 1 and claudin 3 are involved in cell to cell contacts between keratinocytes in human epidermis , although their functional importance remains unknown . . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Genuine expression of claudin 1 and claudin 2 , but not of occludin or claudin 3 , was reciprocal to transepithelial resistance . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Isolated primary rat alveolar epithelial cells in culture also expressed claudin 3 , claudin 4 , and claudin 5 , but showed little claudin 1 and claudin 2 expression . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| In addition , a moderate level of claudin 3 and claudin 1 was detected and both were located in the marginal tight junctions . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Moderate claudin 1 and ZO 1 membranous staining were present , whereas only focal weak claudin 3 and 4 membranous staining was present in normal gastric epithelium . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| The expression of claudin 3 in the esophageal mucosa was decreased , while that of claudin 1 was increased . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that retroviral overexpression of Claudin 1 , but not Claudin 3 , on the right side of the chick embryo between HH stages 4 and 7 randomizes the direction of heart looping . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Occludin , claudin 1 , claudin 2 and claudin 3 are integral membrane proteins found in the tight junction of MDCK cells . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| While molecular expression of junctional adhesion molecule ( JAM ) , ZO 2 , ZO 3 , claudin 2 and claudin 3 were unaltered , ZO 1 , occludin , and claudin 4 were all up regulated ( 1 . 6 , 1 . 6 , 2 . 4 fold , respectively ; P < 0 . 001 0 . 01 ) and claudin 1 down regulated ( 2 . 5 fold ; P < 0 . 05 ) by trans 10 , cis 12 CLA , which may underpin its effects on tight junction function and paracellular Ca transport . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to analyse the expression pattern of TJ molecules occludin ( OCLN ) , claudin 1 ( CLDN 1 ) , claudin 3 ( CLDN 3 ) and claudin 5 ( CLDN 5 ) on mRNA and protein level in patients with edema , venous leg ulcers and healthy controls . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Among 23 CLDN family genes within the human genome , CLDN 1 and CLDN 16 genes were clustered on human chromosome 3q28 , CLDN 3 and CLDN 4 on 7q11 , CLDN 6 and CLDN 9 on 16p13 . 3 , CLDN 8 and CLDN 17 on 21q22 . 11 , CLDN 21 and CLDN 22 on 4q35 . 1 . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| METHODS : Altogether , 56 sections from 52 surgically resected breast specimens were analyzed for CLDN 1 , CLDN 3 and CLDN 4 expression by immunohistochemistry . mRNA was also analyzed using real time PCR in 17 of the 52 cases . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| At the protein level , HFL cells expressed claudin 1 , claudin 3 , claudin 4 , claudin 5 , claudin 7 , and claudin 18 , where levels of expression varied with culture conditions . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry showed expression of claudin 1 , claudin 3 , and ZO 1 in the intercellular junctions of a subpopulation of tumor cells . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| The cldn 3 gene showed a steady increase in expression from pregnancy to involution , while cldn 1 and cldn 4 gene expression increased during pregnancy , but decreased sharply by D 10 of lactation , and once again was significantly increased by D 1 of involution ( P < 0 . 001 for both genes ) . ^^^ The different patterns of gene expression observed between cldn 3 , and cldn 1 , and 4 suggest that different family members may be functionally important at different times during mouse mammary gland development . ^^^ Immunostaining with the cldn 3 antibody showed intense staining of epithelial cells ; however , a lesser degree of staining was evident with the cldn 1 antibody . ^^^ In addition , cldn 1 and cldn 3 are detected in mammary tumors and the wide distribution of cldn 3 in particular , suggest specific roles for these proteins in mammary tumorigenesis . . ^^^ |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15551 and O95832 |
Pubmed |
SVM Score :0.0 |
| NA |
|