| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.54661139 |
| Moreover , tankyrase 2 associates and co localizes with tankyrase 1 , suggesting that both tankyrases might function as a complex . 0.54661139^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| Mammalian TRF 1 and TRF 2 bind the double stranded telomeric repeat sequence and in turn are bound by TIN 2 , TANK 1 , TANK 2 , and hRAP 1 . ^^^ |
|
| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| Using all trans retinoic acid ( ATRA ) sensitive and resistant APL cell lines NB 4 , NB 4 R1 , and NB 4 R2 , we analyzed a panel of telomeric proteins , including TRF 1 , PINX 1 , TANK 1 , and TANK 2 , at the messenger RNA ( mRNA ) and protein expression levels during the differentiation of these cell lines in the 2 pathways . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| Here we report characterization of a second human tankyrase , tankyrase 2 ( TANK 2 ) , which can also interact with TRF 1 but has properties distinct from those of TANK 1 . ^^^ TANK 2 interacted with TRF 1 in yeast and in vitro and localized predominantly to a perinuclear region , similar to the properties of TANK 1 . ^^^ In contrast to TANK 1 , however , TANK 2 caused rapid cell death when highly overexpressed . ^^^ In vivo , TANK 2 may differ from TANK 1 in its intrinsic or regulated PARP activity or its substrate specificity . . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| The incidence of C . perfringens in water samples was 100 % from scald tank 1 , 100 % from scald tank 2 , 100 % from scald tank 3 , 88 % from the prechill tank , and 63 % from the chill tank . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| It is proved that an intermittent aeration cycle of 90 min , with aeration / anoxic mixing periods of 25 30 min / 65 60 min in Tank 1 , and 30 45 min / 60 45 min in Tank 2 , and a DO control set at 0 . 6 1 mg / L during the aeration period are required for satisfactory treatment performance . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| During the course of the study , it was found that the biofilm thickness ( delta ) in Tank 1 ranged from 1 . 2 to 7 . 2 mm and that in Tank 2 from 0 . 5 to 2 . 2 mm ; the biofilm growth against time ( t ) can be simulated as delta=0 . 07t0 . 99 ( R 2 = 0 . 97 , P = 0 . 002 ) in Tank 1 and delta = 0 . 08t0 . 66 ( R 2 = 0 . 81 , P = 0 . 04 ) in Tank 2 . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| The recent identification of a closely related homolog of tankyrase 1 , tankyrase 2 , opens the possibility for a second PARP at telomeres . ^^^ We therefore sought to establish the role of tankyrase 1 at telomeres and to determine if tankyrase 2 might have a telomeric function . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| Analysis of total cellular and nuclear proteins revealed that cells contain approximately twice as much tankyrase 1 as tankyrase 2 . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| Known family members are PARP 1 , PARP 2 , PARP 3 , vPARP , tankyrase 1 and tankyrase 2 , each of them with a possible specific role in cell biology . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| In particular , tankyrase 1 , tankyrase 2 , PARP 2 as well as PARP 1 have been found in association with telomeric DNA and are able to poly ( ADP ribosyl ) ate the telomere binding proteins TRF 1 and TRF 2 , thus blocking their DNA binding activity and controlling telomere extension by telomerase . . ^^^ |
|
| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| Two other nuclear PARP enzymes , tankyrase 1 and tankyrase 2 , are important for telomere maintenance . . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| Human TRF 1 interacts with tankyrase 1 and tankyrase 2 proteins , two related members of the tankyrase family shown to have poly ( ADP ribose ) polymerase activity . ^^^ Human tankyrase 2 is proposed to have activity similar to that of tankyrase 1 , although tankyrase 2 function has been less extensively characterized . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| We show here by overexpression studies that tankyrase 2 , like its closely related homolog tankyrase 1 , can function as a positive regulator of telomere length in human cells , dependent on its catalytic PARP activity . ^^^ |
|
| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| TNKS 1 and TNKS 2 bound to EBNA 1 in coimmunoprecipitation experiments with transfected cell lysates and with purified recombinant proteins in vitro . ^^^ Overexpression of TNKS 1 or TNKS 2 inhibited OriP dependent DNA replication , while a PARP inactive form of TNKS 2 ( M1045V ) was compromised for this inhibition . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| The tnkl gene maps to chromosome 10 , while the tnks gene encoding tankyrase is located on chromosome 8 . ^^^ |
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| Interacting proteins: Q9H2K2 and O95271 |
Pubmed |
SVM Score :0.0 |
| NA |
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