| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.60246378 |
| Tankyrase ( TANK 1 ) is a human telomere associated poly ( ADP ribose ) polymerase ( PARP ) that binds the telomere binding protein TRF 1 and increases telomere length when overexpressed . 0.60246378^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :1.0298368 |
| Tankyrase 1 , a human telomeric poly ( ADP ribose ) polymerase ( PARP ) , positively regulates telomere length through its interaction with TRF 1 , a telomeric DNA binding protein . 1.0298368^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.51846218 |
| Tankyrase 1 , a human telomeric poly ( ADP ribose ) polymerase , was originally identified through its interaction with TRF 1 , a negative regulator of telomere length . 0.51846218^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.55100584 |
| Tankyrase 1 binds TRF 1 via its ankyrin domain and poly ( ADP ribosyl ) ates it . 0.55100584^^^ |
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| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.57963814 |
| Human TRF 1 interacts with tankyrase 1 and tankyrase 2 proteins , two related members of the tankyrase family shown to have poly ( ADP ribose ) polymerase activity . 0.57963814^^^ |
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| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| TRF 1 is known to be eliminated from telomeres by overexpression of TANK 1 , which induces TRF 1 poly ( ADP ribosyl ) ation . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| Mammalian TRF 1 and TRF 2 bind the double stranded telomeric repeat sequence and in turn are bound by TIN 2 , TANK 1 , TANK 2 , and hRAP 1 . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| Using all trans retinoic acid ( ATRA ) sensitive and resistant APL cell lines NB 4 , NB 4 R1 , and NB 4 R2 , we analyzed a panel of telomeric proteins , including TRF 1 , PINX 1 , TANK 1 , and TANK 2 , at the messenger RNA ( mRNA ) and protein expression levels during the differentiation of these cell lines in the 2 pathways . ^^^ |
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| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| Tankyrase 2 oligomerizes with tankyrase 1 and binds to both TRF 1 ( telomere repeat binding factor 1 ) and IRAP ( insulin responsive aminopeptidase ) . ^^^ The poly ( ADP ribose ) polymerase ( PARP ) tankyrase 1 contains an ankyrin repeat domain that binds to various partners , including the telomeric protein TRF 1 ( telomere repeat binding factor 1 ) and the vesicular protein IRAP ( insulin responsive aminopeptidase ) . ^^^ TRF 1 binding recruits tankyrase 1 to telomeres and allows its PARP activity to regulate telomere homoeostasis . ^^^ |
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| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| Tankyrase 1 and 2 are closely related poly ( ADP ribose ) polymerases that use an ankyrin repeat domain to bind diverse proteins , including TRF ( telomere repeat binding factor ) 1 , IRAP ( insulin responsive aminopeptidase ) , and TAB 182 ( 182 kDa tankyrase binding protein ) . ^^^ Interestingly , mouse TRF 1 lacks this motif and thus does not bind either tankyrase 1 or 2 . ^^^ |
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| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| In contrast , overexpression of Mcl 1 proteins suppressed the ADP ribosylation of the telomeric repeat binding factor 1 , another tankyrase 1 interacting protein . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| Previous results showed that ADP ribosylation of TRF 1 by tankyrase 1 released TRF 1 from telomeres and promoted telomere elongation . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| Human telomere length is regulated by the TTAGGG repeat binding protein TRF 1 and its interacting partners tankyrase 1 , TIN 2 and PINX 1 ( refs 5 9 ) . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| The human telomeric DNA binding factor TRF 1 ( hTRF 1 ) and its interacting proteins TIN 2 , tankyrase 1 and 2 , and PINX 1 have been implicated in the regulation of telomerase dependent telomere length maintenance . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| TRF 1 is known to be eliminated from telomeres by overexpression of tankyrase 1 which induces TRF 1 poly ( ADP ribosyl ) ation . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| TIN 2 is a tankyrase 1 PARP modulator in the TRF 1 telomere length control complex . ^^^ TRF 1 itself can be inhibited by the poly ( ADP ribose ) polymerase ( PARP ) activity of its interacting partner tankyrase 1 , which abolishes its DNA binding activity in vitro and removes the TRF 1 complex from telomeres in vivo . ^^^ TIN 2 formed a ternary complex with TRF 1 and tankyrase 1 and stabilized their interaction , an effect also observed with the PARP dead mutant of tankyrase 1 . ^^^ In vitro , TIN 2 protected TRF 1 from poly ( ADP ribosyl ) ation by tankyrase 1 without affecting tankyrase 1 automodification . ^^^ |
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| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| Indeed , when TRF 1 was removed from telomeres by overexpression of the positive telomere length regulator tankyrase 1 , the TIN2 / TINT1 complex remained on telomeres via an increased association with TRF 2 . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| Tankyrase 1 poly ( ADP ribosyl ) ates TRF 1 and releases it from telomeres , allowing access of telomerase to telomeres . ^^^ Conversely , either tankyrase 1 upregulation or telomere shortening , each of which decreased TRF 1 loading on a chromosome end , attenuated the impact of telomerase inhibition . ^^^ |
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| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| In particular , tankyrase 1 , tankyrase 2 , PARP 2 as well as PARP 1 have been found in association with telomeric DNA and are able to poly ( ADP ribosyl ) ate the telomere binding proteins TRF 1 and TRF 2 , thus blocking their DNA binding activity and controlling telomere extension by telomerase . . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| We examined mRNA expression levels of tankyrase 1 and 2 , TRF 1 and 2 , c myc , TERT and TR in Gallus domesticus , the domestic chicken , by quantitative real time PCR , establishing expression profiles for three contrasting cell systems : the pluripotent gastrula , differentiated embryo fibroblasts and transformed DT 40 cells . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| We surveyed common genetic variation in seven genes that are vital to telomere stability ( TERT , POT 1 , TNKS , TERF 1 , TINF 2 , TERF 2 , and TERF2IP ) and validated single nucleotide polymorphisms ( SNPs ) in four different ethnic groups ( n=118 total ) . ^^^ |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95271 and P54274 |
Pubmed |
SVM Score :0.0 |
| NA |
|