| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.71735275 |
| By immunofluorescence analysis , the ASYIP protein was shown to be co localized with ASY in the ER . 0.71735275^^^ |
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| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.0 |
| Our previous study demonstrated that the overexpression of reticulon 3 ( RTN 3 , also named HAP , homologue of ASY protein ) caused apoptosis with the depletion of ER Ca ( 2+ ) stores . ^^^ |
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| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.0 |
| Co immunoprecipitation experiments confirmed a physical association between BACE 1 and RTN 4 B , RTN 4 C ( the shortest isoform of RTN 4 ) , and their homologue reticulon 3 ( RTN 3 ) , both in SH SY5Y cells and in transfected human embryonic kidney ( HEK ) 293 cells . ^^^ |
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| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.0 |
| The reticulon family of proteins has four members , RTN 1 , RTN 2 , RTN 3 and RTN 4 ( also known as Nogo ) , the last of which is well known for its role in inhibiting neuritic outgrowth after injury . ^^^ In brain , BACE 1 mainly colocalizes with RTN 3 in neurons , whereas RTN 4 is more enriched in oligodendrocytes . ^^^ |
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| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.0 |
| While the exact functions of RTN 1 to RTN 3 are unknown , mammalian RTN 4 A / Nogo A was shown to inhibit the regeneration of severed axons in the mammalian central nervous system ( CNS ) . ^^^ Reticulons ( RTNs ) are a family of evolutionary conserved proteins with four RTN paralogs ( RTN 1 , RTN 2 , RTN 3 , and RTN 4 ) present in land vertebrates . ^^^ Phylogenetic and syntenic relationships indicate that the identified fish rtn genes are orthologs of mammalian RTN 1 , RTN 2 , RTN 3 , and RTN 4 and that several paralogous fish genes ( e . g . , rtn 4 and rtn 6 ) resulted from genome duplication events early in actinopterygian evolution . ^^^ |
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| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.0 |
| In contrast to the transcripts of RTN 1 and RTN 2 , RTN 3 A1 shares some significant similarity with RTN 4 A in exon structure , tissue distribution , and brain expression profile . ^^^ Since other reports have shown that RTN 4 A inhibits neuronal outgrowth and restricts the plasticity of the central nervous system , we speculate that RTN 3 A1 might play certain roles in the central nervous system . . ^^^ |
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| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95197 and Q9NQC3 |
Pubmed |
SVM Score :0.0 |
| NA |
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