| Interacting proteins: P55735 and O94979 |
Pubmed |
SVM Score :0.0 |
| The structures marked by Sec31A contain Sec 13 , a component of COPII that is well characterized to mark the ER exit sites . ^^^ Immunoelectron microscopy revealed that Sec31A colocalizes with Sec 13 in structures with extensive vesicular tubular profiles . ^^^ Antibodies raised against a C terminal portion of Sec31A co precipitate Sec 13 and inhibit ER Golgi transport of temperature arrested vesicular stomatitis G protein in a semi intact cell assay . ^^^ Cytosol immunodepleted of Sec31A failed to support vesicular stomatitis G protein transport , which can be rescued by a high molecular weight fraction of the cytosol containing both Sec31A and Sec 13 . ^^^ |
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| Interacting proteins: P55735 and O94979 |
Pubmed |
SVM Score :0.0 |
| The structures marked by Yip1A co localized with Sec31A and Sec 13 , components of the COPII coat protein complex . ^^^ |
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| Interacting proteins: P55735 and O94979 |
Pubmed |
SVM Score :0.0 |
| Sec31B F closely resembles Sec31p and Sec31A , with canonical WD repeats in an N terminal domain that binds Sec 13 and a proline rich C terminal region that presumably binds Sec23 / 24 . ^^^ When expressed as a fusion protein with eYFP in cultured cells , Sec31B F associates with the endoplasmic reticulum and with vesicular tubular clusters , displays restricted intracellular movement characteristic of COPII vesicle dynamics , co distributes on organelles with Sec 13 , Sec31A and Sec 23 ( markers of the COPII coat ) , and concentrates with ts 045 VSV G CFP ( VSV G ) when examined early in the secretory pathway or after temperature or nocodazole inhibition . ^^^ |
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