| Interacting proteins: O76074 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O76074 and P42574 |
Pubmed |
SVM Score :0.0 |
| The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP specific phosphodiesterases ( PDE 6 and PDE 5 ) by caspase 3 . ^^^ We have investigated whether the proteolysis of members of the cGMP binding phosphodiesterases ( PDE 6 , PDE5A1 , and PDE10A2 ) by caspase 3 is modulated by the gamma inhibitor subunit of PDE 6 . ^^^ In contrast , rod PDEgamma converted PDE5A1 ( molecular mass of 98 kDa ) to a better substrate for caspase 3 . ^^^ In addition , caspase 3 induced an approximately 80 % reduction in the activity of a partially purified preparation of PDE5A1 in the presence of rod PDEgamma . ^^^ These data show that rod PDEgamma interacts with at least two members of the cGMP binding PDE family ( PDE5A1 and PDE 6 ) and can exert differential effects on the cleavage of these enzymes by caspase 3 . . ^^^ |
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| Interacting proteins: O76074 and P42574 |
Pubmed |
SVM Score :0.54472462 |
| Interaction of caspase 3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase ( PDE5a1 ) . 0.54472462^^^ |
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