| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.51249547 |
| Allosteric interactions between GB 1 and GB 2 subunits are required for optimal GABA ( B ) receptor function . 0.51249547^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.69324974 |
| Replacing any of the three intracellular loops of GB 2 with their GB 1 counterparts resulted in nonfunctional receptors . 0.69324974^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Molecular identification of the human GABABR 2 : cell surface expression and coupling to adenylyl cyclase in the absence of GABABR 1 . ^^^ We have identified a gene encoding a GABAB receptor , the human GABABR 2 , located on chromosome 9q22 . 1 , that is distinct from the recently reported rat GABABR 1 . ^^^ GABABR 2 structurally resembles GABABR 1 ( 35 % identity ) , having seven transmembrane domains and a large extracellular region , but differs in having a longer carboxy terminal tail . ^^^ GABABR 2 is localized to the cell surface in transfected COS cells , and negatively couples to adenylyl cyclase in response to GABA , baclofen , and 3 aminopropyl ( methyl ) phosphinic acid in CHO cells lacking GABABR 1 . ^^^ The human GABABR 2 and GABABR 1 genes are differentially expressed in the nervous system , with the greatest difference being detected in the striatum in which GABABR 1 but not GABABR 2 mRNA transcripts are detected . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Their molecular structures in the brain are unique and interesting because of heterodimerization consisting of two distinct genes : GABABR 1 and GABABR 2 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Importantly , GABABR 2 receptors can form a heteromeric assembly with GABABR 1 proteins to operate as a heterodimer that displays robust coupling to inward rectifying K+ channels , as well as inhibition of forskolin stimulated adenylate cyclase activity . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Expression and distribution of metabotropic GABA receptor subtypes GABABR 1 and GABABR 2 during rat neocortical development . ^^^ To understand the possible contribution of metabotropic gamma aminobutyric acid receptors ( GABABR ) in cortical development , we investigated the expression pattern and the cellular and subcellular localization of the GABABR 1 and GABABR 2 subtypes in the rat neocortex from embryonic day 14 ( E 14 ) to adulthood . ^^^ At the light microscopic level , both GABABR 1 and GABABR 2 were detected as early as E 14 . ^^^ Using double immunofluorescence , GABABR 1 colocalized with GABABR 2 in neurons of the marginal zone and subplate , indicating that these proteins are coexpressed and could be forming functional GABABRs during prenatal development in vivo . ^^^ In contrast , only GABABR 1 but not GABABR 2 was detected in the tangentially migratory cells in the lower intermediate zone . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To study gamma aminobutyric acid ( GABA ) B receptor subunits GABABR 1 and GABABR 2 protein expression changes after recurrent febrile seizures in the hippocampus of developing rats . ^^^ Immunohistochemical staining was used to demonstrate GABABR 1 and GABABR 2 expressions in brain sections ( 12 microns each ) . ^^^ RESULTS : GABABR 1 and GABABR 2 protein expressions significantly decreased in dentate gyrus and CA 1 CA3 neurons in FS 10 compared with those in F 10 , F 1 , FS 1 and control groups . ^^^ The expressions of GABABR 1 and GABABR 2 protein showed less intense in F 10 than those in FS 1 , F 1 and control groups . ^^^ Throughout the hippocampus , the expressions of GABABR 1 and GABABR 2 protein largely overlaped . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia : immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor , and the GABABR 1 and GABABR 2 receptor subunits . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Recent studies indicate that this receptor is a heterodimer consisting of GABABR 1 ( GBR 1 ) and GABABR 2 subunits . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Three components ( GA , GB 1 , and GB 2 ) of beta glucosidase were detected in the culture filtrate of Pyricularia oryzae grown in a cellulose or cellulose derivative medium . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Avicel , hydroxyethylcellulose and methyl beta D glucoside as the carbon source induced both beta glucosidase components , GB 1 and GB 2 , whereas cellobiose and gentiobiose induced only one component , GB 1 . ^^^ GB 2 was found to be an oligomeric glycoprotein , which consisted of two subunits with molecular weight of approximately 120 , 000 , comprising a relatively large number of acidic amino acids and mannose , as is the case with GB 1 . ^^^ These two isozymes were clearly different in thermostability , GB 2 being more thermolabile than GB 1 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| One group had properties identical to the single channels ( gb 1 ) while the other was consistent with a double barreled channel ( gb 2 ) with coordinated activity between proto channels . ^^^ The single channel slope conductances of gb 1 and gb 2 from 60 to +20 mV with a 250 / 70 mM KCl gradient were 41 and 75 pS , respectively . ^^^ With symmetrical 250 mM KCl , the 1 5 relation of gb 1 showed outward rectification with 47 . 8 + / 6 . 6 pS at cis negative potentials and 68 . 9 + / 6 . 1 pS at cis positive potentials . gb 1 was open from 70 to 95 % at all electrochemical potentials from 80 to +40 mV . gb 2 was steeply voltage dependent between 80 and 20 mV . ^^^ Both gb 1 and gb 2 were insensitive to Ca ( from 100 nm to 1 microM ) , blocked by 0 . 1 mM DIDS and highly selective for chloride . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Kolaviron , a fraction of the defatted ethanol extract , and two biflavones of Garcinia kola seeds ( GB 1 and GB 2 ) significantly modified the action of all these hepatotoxins . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Garcinia biflavanones GB 1 , GB 2 and kolaflavanone were isolated as the active constituents . . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| On the question of the structures of GB 1 , GB1a and GB 2 , a new group of bisflavonoids . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Excluding the predicted N terminal signal sequences , 8 of 9 potential N linked glycosylation sites and all 10 cysteine residues in gB 1 are conserved in both gB 2 and gB 3 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Recombinant fowl poxviruses ( rFPV ) were constructed to express genes from serotype 1 Marek ' s disease virus ( MDV ) coding for glycoproteins B ( gB 1 ) , C ( gC ) , and D ( gD ) and tegument proteins UL 47 and UL 48 , as well as genes from serotypes 2 and 3 MDV coding for glycoprotein B ( gB 2 and gB 3 ) . ^^^ Levels of protection by rFPV / gBs of different MDV serotypes was highest for gB 1 , intermediate for gB 2 , and lowest for gB 3 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| However , in leukocytes of HIV infected patients with < 100 / microL CD 4 cells , gB 1 was found significantly less often than in allograft recipients ( 11 % vs . 36 % ) but gB 2 was more frequent ( 56 % vs . 21 % ; P < . 05 ) . ^^^ The decreased incidence of gBl and increased incidence of gB 2 compared with allograft recipients was also seen in urine of HIV infected patients and reflected the distribution seen in leukocytes . gB 4 was found significantly more often ( P < . 05 ) in semen than in leukocytes of HIV infected patients with < 100 / microL CD 4 cells . gB 1 4 genotypes were similar in patients with < 100 / microL CD 4 cells with or without retinitis . . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Death associated with myelosuppression occurred in 2 . 9 % or 4 of 136 patients with gB 1 , 0 % or 0 of 46 patients with gB 2 , 21 . 7 % or 15 of 69 patients with gB 3 , and 17 . 4 % or four of 23 patients with gB 4 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Whereas 70 % of control ( BSA immunized ) HSV 1 infected animals developed ascending myelitis and died , 100 % of mice immunized with either gB 1 , gB 2 , gD 1 , or gD 2 antigens remained free of clinical illness and survived HSV 1 challenge . ^^^ In contrast , gB 1 or gB 2 immunized mice were not protected against acute HSV 2 induced neurological disease and showed a mortality rate of 60 90 % ( equivalent to that seen in controls ) , although mean survival times were prolonged . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The gB 2 protein had an overall nucleotide and amino acid sequence homology of 86 % with the cognate gB 1 protein . ^^^ These epitopes are included in a region of 98 residues identical between gB 1 and gB 2 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Macrophages from Cornell K strain ( B15B15 ) , GB 1 ( B13B13 ) , and GB 2 ( B6B6 ) chickens and a transformed cell line ( MQ NCSU ) were incubated with or without varying concentrations of bacterial lipopolysaccharide ( LPS ) . ^^^ However , nitrite levels produced by K strain ( 42 microM ) and MQ NCSU ( 41 microM ) macrophages were higher ( P < 0 . 05 ) than those produced by the GB 1 ( 14 microM ) and GB 2 ( 14 microM ) per 1 10 10 ( 6 ) macrophages with optimum LPS concentration range of 50 ng to 1 microgram / mL . ^^^ The increased nitrite production by the K strain and MQ NCSU macrophages corresponded to an increased expression of iNOS mRNA as compared to the mRNA produced by GB 1 and GB 2 macrophages . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| One anaplastic astrocytoma ( AA ) , two glioblastoma multiforme ( GB 1 and GB 2 ) cell lines and three anti GFAP mAbs ( B12C4 , B12B4 and B6C6 , all IgG 1 , kappa ) were used . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| In the blood samples , only gB 1 , gB 2 , and gB 3 genotypes were observed . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Three cell lines were examined in detail : two human glioblastoma cell lines , GB 1 and GB 2 , and one gliosarcoma cell line , GS 1 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The distribution of CMV genotypes was : gB 1 , 19 ( 36 % ) patients ; gB 2 , 15 ( 28 % ) patients ; gB 3 , 13 ( 24 % ) patients ; and gB 4 , 4 ( 8 % ) patients . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Characterization of the tissue distribution of each of the receptors by in situ hybridization histochemistry in rat brain revealed co localization of gb 1 and gb 2 transcripts in many brain regions , suggesting the hypothesis that gb 1 and gb 2 may interact in vivo . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Protium deuterium fractionation factors ( phi ) were determined for more than 85 % of the backbone amide protons in the IgG binding domains of protein G , GB 1 and GB 2 , from NMR spectra recorded over a range of H2O / D2O solvent ratios . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| In patient 3 , a ganciclovir resistant UL 97 mutant virus with a gB 1 genotype was cultured from the lung , whereas the CMV in the brain did not contain mutations and its genotype was gB 2 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Specifically , message levels for gb 2 were virtually absent in the caudate / putamen , and significantly lower in the medial basal hypothalamus , septum and brainstem as compared with gb 1 message levels . ^^^ In contrast to gb 1 , gb 2 mRNA was never detected in white matter suggesting that gb 2 message is found exclusively in neurons . ^^^ Finally , in rat brain regions showing significant overlap of message for gb 1 and gb 2 , the transcripts are often found in the same cells . ^^^ Data from our previous work showing that coexpression of gb 2 with gb 1 is necessary for expression of a functional receptor together with the detailed anatomical data presented here indicate that native GABA ( B ) receptors function as heteromeric proteins , the most abundant form being the gb1 / gb2 receptor . ^^^ However , the more limited distribution of gb 2 receptor mRNA suggests that there are brain regions where GABA ( B ) receptors are composed of gb 1 and as yet unidentified family members . . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| We next examined whether mGluR 4 , which forms homodimers and is structurally related to GABA ( B ) , could act as a surrogate coreceptor for gb 1 or gb 2 . ^^^ GABA activated distal signaling events resulted only after the coexpression and heterodimerization of gb 1 and gb 2 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The effect of kolaviron , a mixture of Garcinia biflavonoid 1 ( GB 1 ) , Garcinia biflavonoid 2 ( GB 2 ) and kolaflavanone , used in the treatment of various ailments in southern Nigeria on hepatotoxicity and lipid peroxidation induced by 2 acetylaminofluorene ( 2 AAF ) in rats was investigated . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Two peptides from corresponding segments of the N terminus of HSV 1 and HSV 2 glycoprotein B ( gB ) , i . e . peptide gB 1 ( 60 73 ) ( GAAPTGDPKPKKNK ) and peptide gB 2 ( 55 68 ) ( SPATTKARKRKTKK ) , were identified as immunogenic . ^^^ Peptide gB 1 ( 60 73 ) allowed the discrimination between HSV 1 and HSV 2 type specific antibodies with a specificity of 67 % , whereas peptide gB 2 ( 55 68 ) reacted in a strictly HSV 2 type specific manner . ^^^ It is concluded that peptides from the N terminus of gB 1 and gB 2 are recognized predominantly by human sera in an HSV specific manner . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Surface expression of GABA ( B ) receptors requires heterodimerization of GB 1 and GB 2 subunits , but little is known about mechanisms that ensure efficient heterodimer assembly . ^^^ Interaction of GB 1 and GB 2 through their C terminal coiled coil alpha helices masks the retention signal in GB 1 , allowing the plasma membrane expression of the assembled complexes . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Purified gC and gB proteins differed with respect to sensitivity of their interaction with HS to increased concentrations of sodium chloride in the order gB 2 > gB 1 > gC 1 > gC 2 . ^^^ The O sulfate groups of heparin were found to be more important for interaction with gB 1 than gB 2 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| However , the cloning of GABA ( B ) gb 1 and gb 2 receptor genes and identification of the functional GABA ( B ) gb 1 gb2 receptor heterodimer have so far failed to substantiate the existence of pharmacologically distinct receptor subtypes . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The most prevalent genotype was gB 1 ( 42 % ) followed by gB 3 ( 26 % ) , gB 2 ( 19 % ) and gB 4 ( 13 % ) . ^^^ Rates of disease and CNS damages were higher among children infected by gB 1 ( 35 % , 17 % ) and gB 3 ( 31 % , 28 % ) than in those infected by gB 2 and gB 4 ( 20 % , 17 % and 13 % , 15 % , respectively ) . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Three patients ( 8 % ) were infected by a gB 1 strain , 26 ( 70 % ) by a gB 2 strain , 2 ( 5 . 5 % ) by a gB 3 strain , 1 ( 3 % ) by a gB 4 strain , and 5 ( 13 . 5 % ) by mixed gB strains . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Among the GPCRs , the gamma aminobutyric acid ( GABA ) type B receptor ( GABA ( B ) R ) is the only one known so far that needs two subunits , GB 1 and GB 2 , to function . ^^^ To that end , point mutations in the highly conserved third intracellular loop known to prevent G protein activation of the related Ca sensing or metabotropic glutamate receptors were introduced into GB 1 and GB 2 . ^^^ One mutation , L686P introduced in GB 2 prevents the formation of a functional receptor , even though the heteromer reaches the cell surface , and even though the mutated subunit still associates with GB 1 and increases GABA affinity on GB 1 . ^^^ Accordingly , whereas in all GPCRs the same protein is responsible for both agonist binding and G protein activation , these two functions are assumed by two distinct subunits in the GABA ( B ) heteromer : one subunit , GB 1 , binds the agonists whereas the other , GB 2 , activates the G protein . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Ligand induced signal transduction within heterodimeric GABA ( B ) receptor . gamma aminobutyric acid type B ( GABA ( B ) ) receptors , G protein coupled receptors ( GPCRs ) for GABA , are obligate heterodimers of two homologous subunits , GB 1 and GB 2 . ^^^ Typical for family C GPCRs , the N termini of both GB 1 and GB 2 contain a domain with homology to bacterial periplasmic amino acid binding proteins ( PBPs ) , but only the GB 1 PBP like domain binds GABA . ^^^ We found that both GB 1 and GB 2 extracellular N termini are required for normal coupling of GABA ( B ) receptors to their physiological effectors , G ( 1 ) and G protein activated K ( + ) channels ( GIRKs ) . ^^^ Receptors with two GB 2 N termini did not respond to GABA , whereas receptors with two GB 1 N termini showed increased basal activity and responded to GABA with inhibition , rather than activation , of GIRK channels . ^^^ This GABA induced GIRK current inhibition depended on GABA binding to the chimeric GB ( 1 / 2 ) subunit ( the GB 1 N terminal domain attached to the heptahelical domain of GB 2 ) , rather than the wild type GB 1 subunit . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The distribution of CMV gB genotypes was : gB 1 , 15 / 58 ( 25 . 9 % ) ; gB 2 , 16 / 58 ( 27 . 6 % ) ; gB 3 , 21 / 58 ( 36 . 2 % ) ; gB 4 , 2 / 58 ( 3 . 4 % ) and four patients ( 6 . 9 % ) had mixed infection . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The results showed that macrophages from K strain ( B ( 15 ) B ( 15 ) ) ( range from two separate trials : 31 89 microM ) and MQ NCSU ( 22 81 microM ) were high responders whereas macrophages from both GB 1 ( B ( 13 ) B ( 13 ) ) ( 15 38 microM ) and GB 2 ( B ( 6 ) B ( 6 ) ) ( 7 15 microM ) chickens were low responders against all LPSs used . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The four biflavanones of interest ( GB 1 , GB 2 and GB 1 glycoside and kolaflavanone ) were quantified in a traditional tea preparation , and two commercially available ethanolic formulations . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| HCMV gB genotype 2 was found more frequently than other genotypes ( gB 2 , 40 % ; gB 1 , 30 % ; gB 3 , 25 % ; and gB 4 , 5 % ) in renal transplant recipients . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| At the onset of treatment , the distribution of CMV gB genotypes was as follows : gB 1 , 19 / 50 ( 38 % ) ; gB 2 , 9 / 50 ( 18 % ) ; gB 3 , 12 / 50 ( 24 % ) ; gB 4 , 2 / 50 ( 4 % ) ; and mixed genotype infection , 8 / 50 ( 16 % ) . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The gamma aminobutyrate B ( GABA ( B ) ) receptor is the first discovered G protein coupled receptor ( GPCR ) that needs two subunits , GB 1 and GB 2 , to form a functional receptor . ^^^ The GB 1 extracellular domain ( ECD ) binds GABA , and GB 2 contains enough molecular determinants for G protein activation . ^^^ GB 1 and GB 2 are structurally related to the metabotropic glutamate , Ca ( 2+ ) sensing and other family 3 GPCRs in which the second ( i 2 ) as well as the third ( i 3 ) intracellular loop play important roles in G protein coupling . ^^^ Here , the role of the i 2 loops of GB 1 and GB 2 in the GABA ( B ) receptor ability to activate G ( alpha ) proteins is investigated . ^^^ To that aim , the i 2 loops were swapped between GB 1 and GB 2 heptahelical domains ( HDs ) , either in the wild type subunits or in the chimeric subunits GB1 / 2 that contain the ECD of GB 1 and the HD of GB 2 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Although pharmacological differences have been observed between various GABA ( B ) mediated effects , a single GABA ( B ) receptor composed of two subunits ( GB 1 and GB 2 ) has been identified . ^^^ Although GB 1 binds GABA , GB 2 plays a critical role in G protein activation . ^^^ Moreover , GB 2 is required for the high agonist affinity of GB 1 . ^^^ Like any other family 3 G protein coupled receptors , GB 1 and GB 2 are composed of a Venus Flytrap module ( VFTM ) that usually contains the agonist binding site and a heptahelical domain . ^^^ Here , we have further refined the GABA binding site of GB 1 and characterized the putative binding site in the VFTM of GB 2 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Significant independent associations between some genotypes and particular HLA alleles were observed : gB 1 was more frequent in the HLA A 24 or HLA B 7 context and underrepresented in patients with HLA DR 11 ; gB 2 was more frequent in HLA A 32 or HLA DR 11 carriers ; and an increased frequency of gB 3 was observed in the HLA A 29 context . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| In neonates three genotypes ( gB 1 , gB 2 and gB 3 ) , were determined while AIDS patients and blood donors only showed one ( gB 2 ) . ^^^ Of all samples analyzed only genotypes gB 1 , 2 and 3 were determined , genotype gB 2 was the most frequent ( 73 % ) and mixed infections were not detected . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The distribution of gB genotypes was as follows : gB 1 , 28 . 9 % of patients ; gB 2 , 19 . 6 % ; gB 3 , 23 . 7 % ; gB 4 , 2 . 0 % ; and mixed infection , 25 . 8 % . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The hypolipidaemic effect of kolaviron , a mixture of Garcinia biflavonoid 1 ( GB 1 ) , Garcinia biflavonoid 2 ( GB 2 ) and kolaflavanone , used in the treatment of various ailments in southern Nigeria , was investigated in rats . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Agonist induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO K 1 cells . gamma Aminobutyric acid B ( GABA ( B ) ) receptor is the first discovered G protein coupled receptor that requires two subunits , GB 1 and GB 2 , to form a functional receptor . ^^^ Fusion proteins were generated by attachment of cyan fluorescent protein ( CFP ) and yellow fluorescent protein ( YFP ) to GB 1 and GB 2 , respectively , and confocal microscopy experiments in intact living cells semi stably expressing the constructs were performed . ^^^ Incubation of co expressing CFP GB 1 and YFP GB 2 cells in the presence of GABA ( 100 microM ) for 2 h induced a profound receptor internalization , and CFP GB 1 and YFP GB 2 appeared co localized in the endosome ( labelled with Cy 3 transferrin ) . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The gamma aminobutyric acid type B ( GABAB ) receptor is an allosteric complex made of two subunits , GABAB 1 ( GB 1 ) and GABAB 2 ( GB 2 ) . ^^^ GB 1 binds GABA , and GB 2 plays a major role in G protein activation as well as in the high agonist affinity state of GB 1 . ^^^ We show that isolated versions of GB 1 and GB 2 VFTs in the absence of the HD and C terminal tail can form hetero oligomers as shown by time resolved fluorescence resonance energy transfer ( based on HTRF technology ) . ^^^ GB 2 VFT and its association with GB 1 VFT controlled agonist affinity in GB 1 in two ways . ^^^ First , GB 2 VFT exerted a direct action on GB 1 VFT , as it slightly increased agonist affinity in isolated GB 1 VFT . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| The rFPV containing gB 1 provides better protection than rFPV containing gB 2 or gB 3 in all three B genotypes . ^^^ Moreover , the gB proteins were critical , since the B * 21 / * 21 chickens had better protection than chickens with B * 13 / * 13 or B * 5 / * 5 using rFPV with gB 1 , gB 2 , or gB 3 . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The distribution of GB types were as follows : GB 1 , 19 / 38 ( 50 . 0 % ) ; GB 2 , 3 / 38 ( 7 . 9 % ) , GB 3 , 14 / 38 ( 36 . 8 % ) . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| Its GB 1 subunit , carrying the retention signal RSR , only reaches the cell surface when associated with the GB 2 subunit . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| CSF samples obtained early after the onset of GBS were significantly more likely to be positive for CMV DNA ( P= . 048 ) . gB 1 was the most prevalent genotype detected in patients with GBS ( 88 % ) , followed by gB 3 ( 8 % ) and gB 2 ( 4 % ) . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| In all these cases , the most prevalent genotype was gB 1 ( 50 . 63 % ) , followed by gB 3 ( 21 . 52 % ) , gB 2 ( 17 . 72 % ) , and coinfection ( 10 . 13 % ) ; gB 4 was not found . ^^^ The gB 1 genotype is the most prevalent in Chinese infants with congenital CMV disease , especially in those with liver damage , followed by genotypes gB 3 , gB 2 , and gB4 . . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| In Brome mosaic virus ( BMV ) , genomic RNA 1 ( gB 1 ) and RNA 2 ( gB 2 ) , encoding the replication factors , are packaged into two separate virions , whereas genomic RNA 3 ( gB 3 ) and its subgenomic coat protein ( CP ) mRNA ( sgB 4 ) are copackaged into a third virion . ^^^ Cultures of agrotransformants , engineered to express sgB 4 and CP subunits either transiently ( sgB 4 ( Trans ) and CP ( Trans ) ) or in replication dependent transcription and translation when complemented with gB 1 and gB 2 ( sgB 4 ( Rep ) and CP ( Rep ) ) , were mixed in all four pair wise combinations and infiltrated to Nicotiana benthamiana leaves to systematically evaluate requirements regulating sgB 4 packaging . ^^^ |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75899 and Q9UBS5 |
Pubmed |
SVM Score :0.0 |
| NA |
|