| Among overexpressed proteins were transcription factors ( nucleoside diphosphate kinase 1 ) and enzymes involved in gene silencing ( chromobox protein ) , protein synthesis ( 39S ribosomal protein L 12 , BiP protein , protein disulfide isomerase ) , degradation ( cytosol aminopeptidase , endopeptidase Clp , inorganic pyrophosphatase ) and energy metabolism ( acyl CoA dehydrogenase , isocitrate dehydrogenase , NADH ubiquinone oxidoreductase , pyruvate dehydrogenase ) , heat shock proteins ( 60 and 70 kd ) , structural proteins ( cytokeratins ) and membrane proteins ( stomatinlike protein 2 ) . ^^^ |