| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.51887425 |
| In addition , Smad 3 was not able to directly bind the ARE in a DNase 1 protection assay , in which FAST 2 binds the ARE around a motif ( TGTGTATT ) previously characterized to associate with the human FAST 1 protein . 0.51887425^^^ |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| Smad 2 and Smad 3 positively and negatively regulate TGF beta dependent transcription through the forkhead DNA binding protein FAST 2 . ^^^ |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| Structural basis for the functional difference between Smad 2 and Smad 3 in FAST 2 ( forkhead activin signal transducer 2 ) mediated transcription . ^^^ In FAST 2 ( forkhead activin signal transducer 2 ) mediated transcriptional regulation using the activin responsive element derived from Xenopus Mix . 2 promoter as a reporter , Smad 3 but not Smad 2 alone was able to stimulate the transcription . ^^^ Taken together , these results suggest that , as compared with Smad 2 , the unique function of Smad 3 in modulating the FAST 2 mediated transcription is contributed to by a subtle difference in the structural features at the MH 1 domain . . ^^^ |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| In transient transfection experiments , overexpression of CBF Cb was able to repress the transactivating activity of Smad 2 and Smad 3 , mediated either by direct binding to the Smad responsive element or through their association with the Smad interacting transcription factor FAST 2 ( forkhead activin signal transducer 2 ) . ^^^ |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| In contrast , Smad 2 ( wt ) , Smad2Deltaexon3 , and Smad 3 efficiently formed ARE binding complexes with Smad 4 and FAST 1 , although Smad 2 ( wt ) did not directly bind to ARE . ^^^ |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| This complex contains Smad 2 or Smad 3 , Smad 4 , and a novel forkhead transcription factor , FAST 1 , and binds to an enhancer ( activin responsive element ; ARE ) that confers activin regulation of Mix . 2 transcription . ^^^ |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| All these Smad 4 variants form complexes with activated Smad 2 and Smad 3 and are incorporated into DNA binding complexes with the transcription factor Fast 1 , regardless of the amount of linker they contain . ^^^ |
|
| Interacting proteins: O75593 and P84022 |
Pubmed |
SVM Score :0.0 |
| In contrast , transcription factors Mixer and FoxH 3 ( FAST 1 ) bind to the bottom side of the Smad 3 MH2 toroid ; therefore , c Ski does not affect the interaction of Smads with these transcription factors . ^^^ |
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