| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Disabled 1 ( Dab 1 ) , an intracellular adapter protein containing a PTB ( phosphotyrosine binding ) domain , is tyrosyl phosphorylated during embryogenesis , but it accumulates in a hypophosphorylated form in mice lacking Reelin or both very low density lipoprotein receptor and apolipoprotein E receptor 2 . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in Reelin , Disabled 1 ( Dab 1 ) , or both the very low density lipoprotein receptor ( VLDLR ) and the apolipoprotein E receptor 2 ( ApoER 2 ) exhibit identical neuroanatomic defects in laminar structures throughout the brain . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2 , thereby inducing tyrosine phosphorylation of the adaptor protein Disabled 1 ( Dab 1 ) and suppressing tau phosphorylation in vivo . ^^^ We present genetic evidence that this cascade is dependent on apolipoprotein E receptor 2 , very low density lipoprotein receptor , and Dab 1 . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Reelin , Disabled 1 ( Dab 1 ) , apolipoprotein E receptor 2 ( ApoER 2 ) , and very low density lipoprotein receptor ( VLDLR ) participate in a signaling pathway required for layer formation during mammalian brain development . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| In developing mammalian ( mouse ) brain , Reelin ( Reln ) is secreted by the Cajal Retzius ( CR ) neurons in the marginal zone , binds apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( Vldlr ) , and induces the phosphorylation of the downstream cytoplasmic molecule disabled 1 ( Dab 1 ) in cortical plate neurons . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Because the Dab 1 phosphotyrosine binding domain can interact simultaneously with membrane lipids and with the intracellular domains of apolipoprotein E receptor 2 and very low density lipoprotein receptor , Dab 1 is preferentially recruited to the neuronal plasma membrane , where it is phosphorylated . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Reelin is secreted by Cajal Retzius cells and binds to the very low density lipoprotein receptor and apolipoprotein E receptor type 2 receptors on the surface of CP cells , inducing tyrosine phosphorylation of the intracellular Dab 1 adapter . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| It binds to lipoprotein receptors very low density lipoprotein receptor and apolipoprotein E receptor type 2 , thereby inducing phosphorylation of the adapter Dab 1 . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Reelin binding to apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( VLDLR ) leads to phosphorylation of disabled 1 ( Dab 1 ) , an adaptor protein which associates with the intracellular domains of both receptors . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Furthermore , serine and threonine phosphorylation increased the interaction of LRP with other adaptor proteins such as Dab 1 and CED 6 / GULP . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| Reelin , a large protein that regulates neuronal migration during embryonic development , activates a conserved signaling pathway that requires its receptors , very low density lipoprotein receptor and apolipoprotein E receptor 2 , the cytoplasmic adaptor protein Disabled 1 ( Dab 1 ) , and Src family kinases ( SFK ) . ^^^ |
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| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75553 and Q07954 |
Pubmed |
SVM Score :0.0 |
| NA |
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