| Interacting proteins: O75553 and P46108 |
Pubmed |
SVM Score :0.0 |
| Of these , the Crk family proteins ( CrkL , CrkI , and CrkII ) , bind significant quantities of Dab 1 when embryonic cortical neurons are exposed to Reelin . ^^^ |
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| Interacting proteins: O75553 and P46108 |
Pubmed |
SVM Score :0.0 |
| We further show that Crk 1 and Crk 2 , but not CrkL , stimulate phosphorylation of Dab 1 on tyrosine 220 in a Src dependent manner . ^^^ |
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| Interacting proteins: O75553 and P46108 |
Pubmed |
SVM Score :0.0 |
| Overexpression of CrkIIGFP rescued the migration of these cells , suggesting that Dab 1 makes Crk a limiting factor for migration . ^^^ We propose a model that tyrosine phosphorylated Dab 1 engages the conserved Crk Dock 1 Rac signaling cassette , but when bound to Dab 1 this signaling complex does not support migration . . ^^^ Interaction between Dab 1 and CrkII is promoted by Reelin signaling . ^^^ Here we identify CrkII , CrkL and Dock 1 in complexes bound to tyrosine phosphorylated Dab 1 , through mass spectrometry . ^^^ The CrkII Dab 1 interaction requires tyrosine phosphorylation of Dab 1 at residues 220 or 232 and is promoted by Reelin treatment of embryonic forebrain neurons . ^^^ |
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| Interacting proteins: O75553 and P46108 |
Pubmed |
SVM Score :0.0 |
| Furthermore , receptor independent membrane targeting of Dab 1 is required for its interaction with Src and Crk , and disruption of phosphoinositide binding also blocks subsequent Reelin induced tyrosine phosphorylation of Dab1 . . ^^^ |
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