| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Here we show that the amino terminal phosphotyrosine binding ( PTB ) domain of Dab 1 binds to the transmembrane glycoproteins of the amyloid precursor protein ( APP ) and low density lipoprotein receptor families and the cytoplasmic signaling protein Ship . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Genetic evidence suggests that interpretation of the Reelin signal by migrating neurons involves two neuronal cell surface proteins , the very low density lipoprotein receptor ( VLDLR ) and the apoE receptor 2 ( ApoER 2 ) as well as a cytosolic adaptor protein , Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Loss of the Reln receptor proteins , apolipoprotein receptor 2 and very low density lipoprotein receptor , results in a Reln like phenotype accompanied by increased Dab 1 protein expression . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Disabled 1 ( Dab 1 ) , an intracellular adapter protein containing a PTB ( phosphotyrosine binding ) domain , is tyrosyl phosphorylated during embryogenesis , but it accumulates in a hypophosphorylated form in mice lacking Reelin or both very low density lipoprotein receptor and apolipoprotein E receptor 2 . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in Reelin , Disabled 1 ( Dab 1 ) , or both the very low density lipoprotein receptor ( VLDLR ) and the apolipoprotein E receptor 2 ( ApoER 2 ) exhibit identical neuroanatomic defects in laminar structures throughout the brain . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2 , thereby inducing tyrosine phosphorylation of the adaptor protein Disabled 1 ( Dab 1 ) and suppressing tau phosphorylation in vivo . ^^^ We present genetic evidence that this cascade is dependent on apolipoprotein E receptor 2 , very low density lipoprotein receptor , and Dab 1 . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| The DAB 1 protein docks to the intracellular part of the Reelin very low density lipoprotein receptor and apoE receptor type 2 and becomes tyrosine phosphorylated following binding of Reelin to cortical neurons . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Reelin , Disabled 1 ( Dab 1 ) , apolipoprotein E receptor 2 ( ApoER 2 ) , and very low density lipoprotein receptor ( VLDLR ) participate in a signaling pathway required for layer formation during mammalian brain development . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| We studied the postnatal development of the radial glial scaffold in the dentate gyrus of reeler mice , lacking the extracellular matrix protein Reelin , in scrambler mice , deficient in the intracellular adaptor protein disabled 1 ( Dab 1 ) , which is required for the transmission of the Reelin signal into the cell , and in mutant mice lacking the Reelin receptors apolipoprotein receptor 2 ( ApoER 2 ) and / or the very low density lipoprotein receptor ( VLDLR ) , known to transmit the Reelin signal via Dab 1 . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Formation of the mammalian six layered neocortex depends on a signaling pathway that involves Reelin , the very low density lipoprotein receptor , the apolipoprotein E receptor 2 ( ApoER 2 ) , and the adaptor protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| In developing mammalian ( mouse ) brain , Reelin ( Reln ) is secreted by the Cajal Retzius ( CR ) neurons in the marginal zone , binds apolipoprotein E receptor 2 ( ApoER 2 ) and very low density lipoprotein receptor ( Vldlr ) , and induces the phosphorylation of the downstream cytoplasmic molecule disabled 1 ( Dab 1 ) in cortical plate neurons . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| The Reelin signaling pathway controls neuronal positioning during mammalian brain development by binding to the very low density lipoprotein receptor and apolipoprotein E receptor 2 , and signaling through the intracellular adapter protein Disabled 1 ( Dab 1 ) . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Because the Dab 1 phosphotyrosine binding domain can interact simultaneously with membrane lipids and with the intracellular domains of apolipoprotein E receptor 2 and very low density lipoprotein receptor , Dab 1 is preferentially recruited to the neuronal plasma membrane , where it is phosphorylated . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Reelin is secreted by Cajal Retzius cells and binds to the very low density lipoprotein receptor and apolipoprotein E receptor type 2 receptors on the surface of CP cells , inducing tyrosine phosphorylation of the intracellular Dab 1 adapter . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Binding of Reelin to the neuronal apolipoprotein E receptors apoER 2 and very low density lipoprotein receptor induces tyrosine phosphorylation of Dab 1 and the subsequent activation or relocalization of downstream targets like phosphatidylinositol 3 ( PI 3 ) kinase and Nckbeta . ^^^ The Reelin induced Dab 1 degradation also depends on apoER 2 and very low density lipoprotein receptor in a gene dose dependent manner . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Dab 1 interacts with NPXY motifs in the cytoplasmic tails of the lipoprotein receptors ApoER 2 and very low density lipoprotein receptor through an amino terminal phosphotyrosine binding ( PTB ) domain . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Reelin binds to various cell surface receptors , including two members of the low density lipoprotein receptor family that also bind to Dab 1 . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| Reelin , a large protein that regulates neuronal migration during embryonic development , activates a conserved signaling pathway that requires its receptors , very low density lipoprotein receptor and apolipoprotein E receptor 2 , the cytoplasmic adaptor protein Disabled 1 ( Dab 1 ) , and Src family kinases ( SFK ) . ^^^ |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01130 and O75553 |
Pubmed |
SVM Score :0.0 |
| NA |
|