| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.85906843 |
| CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex . 0.85906843^^^ |
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| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| Recombinant CLF 1 in complex with its physiologic ligand , cardiotrophin like cytokine ( CLC ) , triggered phosphorylation of signal transducer and activator of transcription 3 in mesenchyme , a pathway characteristic of mesenchymal to epithelial conversion . ^^^ Indeed , when applied to isolated rat metanephric mesenchyme , CLF 1 / CLC ( 3 nM ) induced mature nephron structures expressing glomerular and tubular markers . ^^^ |
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| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| One candidate is the heterodimer formed by cardiotrophin like cytokine ( CLC ) and cytokine like factor 1 ( CLF ) . ^^^ |
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| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| The recently identified IL 6 family member cardiotrophin like cytokine ( also named novel neurotrophin 1 or B cell stimulating factor 3 ) forms a secreted complex with cytokine like factor 1 which binds and activates the tripartite ciliary neurotrophic factor receptor . ^^^ |
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| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| Cardiotrophin like cytokine ( CLC ) cytokine like factor 1 ( CLF ) composite cytokine is a second ligand for the CNTF alpha component receptor ( CNTFRalpha ) . ^^^ |
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| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| We recently demonstrated that cardiotrophin like cytokine ( CLC ) associates with the soluble orphan receptor cytokine like factor 1 ( CLF ) to form a heterodimeric cytokine that displayed activities only on cells expressing the tripartite CNTF receptor on their surface . ^^^ In this present study we examined the membrane binding of the CLC / CLF composite cytokine and observed a preferential interaction of the cytokine with the CNTFR subunit . ^^^ Signaling pathways recruited by the CLC / CLF complex in human neuroblastoma cell lines were also analyzed in detail . ^^^ In contrast to that reported before for CNTF , soluble CNTFR failed to promote the action CLC / CLF , and an absolute requirement of the membrane form of CNTFR was required to generate a functional response to the composite cytokine . ^^^ This study reinforces the functional similarity between CNTF and the CLC / CLF composite cytokine defining the second ligand for CNTFR . . ^^^ |
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| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| Although CLC contains a putative signal peptide and therefore should enter into the classical secretory pathway , the protein has been shown to be retained within transfected mammalian cells , unless coexpressed with either sCNTFR or cytokine like factor ( CLF ) [ Elson , G . ^^^ |
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| Interacting proteins: O75462 and Q9UBD9 |
Pubmed |
SVM Score :0.0 |
| Two different contact sites are recruited by cardiotrophin like cytokine ( CLC ) to generate the CLC / CLF and CLC / sCNTFRalpha composite cytokines . ^^^ Both are composite cytokines formed by cardiotrophin like cytokine ( CLC ) associated to either the soluble type 1 cytokine receptor CLF or the soluble form of CNTF receptor alpha ( CNTFRalpha ) . ^^^ Importantly , we found that CLC interacts with the soluble forms of CNTFRalpha and CLF via sites 1 and 3 , respectively . ^^^ Surprisingly , the residues that are important for the interaction of CLC with CLF are part of the conserved FXXK motif of site 3 known to be the interaction site of LIFRbeta . ^^^ This study establishes the molecular details of the interaction of CLC with CLF , CNTFRalpha , and LIFRbeta and helps to define the precise role of each protein in this functional receptor complex . . ^^^ |
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