| TRAP 220 also interacts with other nuclear receptors [ vitamin D receptor , retinoic acid receptor alpha , retinoid 10 receptor alpha , peroxisome proliferation activated receptor ( PPAR ) alpha , PPARgamma and , to a lesser extent , estrogen receptor ] in a ligand dependent manner , whereas TRAP 100 shows only marginal interactions with estrogen receptor , retinoid 10 receptor alpha , PPARalpha , and PPARgamma . ^^^ |