| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| Early studies have suggested that HDAC 3 activity is regulated by association with the corepressors N CoR and SMRT . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| We report here that ETO ( eight twenty one or MTG 8 ) , which is fused to the acute myelogenous leukemia 1 ( AML 1 ) transcription factor in t ( 8 ; 21 ) AML , interacts via its zinc finger region with a conserved domain of the corepressors N CoR and SMRT and recruits HDAC in vivo . ^^^ The fusion protein AML 1 ETO retains the ability of ETO to form stable complexes with N CoR / SMRT and HDAC . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| Recruitment of SMRT / N CoR mSin3A HDAC repressing complexes is not a general mechanism for BTB / POZ transcriptional repressors : the case of HIC 1 and gammaFBP B . ^^^ In the human B cell lymphoma ( BCL 6 ) and promyelocityc leukemia ( PLZF ) oncoproteins , this domain mediates transcriptional repression through its ability to recruit a silencing mediator of retinoid and thyroid hormone receptor ( SMRT ) / nuclear receptor corepressor ( N CoR ) mSin3A histone deacetylase ( HDAC ) complex , a mechanism shared with numerous transcription factors . ^^^ However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , however , numerous biochemical studies have not detected N CoR or SMRT in mSin 3 and HDAC 1 containing complexes . ^^^ Here we show that these RDs are nonredundant , and that one RD , which is conserved in N CoR and SMRT , represses transcription by interacting directly with class 2 HDAC 4 and HDAC 5 . ^^^ Endogenous N CoR and SMRT each associate with HDAC 4 in a complex that does not contain mSin3A or HDAC 1 . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| The class 1 deacetylases HDAC 1 and HDAC 2 are components of multisubunit complexes , one of which could associate with the nuclear hormone receptor corepressor , N CoR . ^^^ N CoR also interacts with class 2 deacetylases HDAC 4 , HDAC 5 , and HDAC 7 . ^^^ Deletion analysis of N CoR revealed that HDAC 3 binds multiple N CoR regions in vitro and that all of these regions are required for maximal binding in vivo . ^^^ The N CoR domains that interact with HDAC 3 are distinct from those that bind other HDACs . ^^^ Transient overexpression of HDAC 3 and microinjection of Abs against HDAC 3 showed that a component of transcriptional repression mediated by N CoR depends on HDAC 3 . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| Association of PML RAR and AML 1 ETO with the nuclear corepressor ( N CoR ) / histone deacetylase ( HDAC ) complex is required to block hematopoietic differentiation . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| We find that both 5 ErbA and TR can recruit the corepressor N CoR , but , in contrast to existing models , show a concomitant enrichment for HDAC 3 that occurs without an association with Sin 3 , HDAC1 / RPD3 , Mi 2 or HDAC 5 . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| The structure appears to contain both class 1 and the recently described class 2 histone deacetylases ( HDAC ) 5 and 7 along with the nuclear receptor corepressors SMRT ( silencing mediator for retinoid and thyroid receptor ) and N CoR ( nuclear receptor corepressor ) . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| Based on Western blotting using antibodies against known subunits , the only HDAC found in the N CoR 1 complex was HDAC 3 . ^^^ In contrast , N CoR 2 contained predominantly HDAC 1 and HDAC 2 as well as several other subunits that are found in the Sin3A . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| We provide evidence that the transcriptional corepressors SMRT and N CoR could serve as critical mediators of HDAC 7 activity by binding class 2 HDACs and HDAC 3 by two distinct repressor domains . ^^^ Different class 2 HDACs reside in the cell nucleus in stable and autonomous complexes with enzymatic activity , but the enzymatic activities associated with HDAC 7 and HDAC 4 rely on shared cofactors , including HDAC 3 and SMRT / N CoR . . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| These results suggest that ER alpha Delta AF 2 and similar mutant receptors recently found associated with certain tumors may actively perturb the normal E ( 2 ) signaling via SWI / SNF , N CoR / SMRT , and HDAC . . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| A cognate DAD is present in the related corepressor N CoR , which can also activate HDAC 3 . ^^^ Thus , SMRT and N CoR do not serve merely as platforms for HDAC recruitment but function as an integral component of an active cellular HDAC 3 enzyme . . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| In this work , we show that unliganded TR specifically recruits only the closely related N CoR and SMRT HDAC 3 complexes , whereas the Mad 1 recruits only the Sin 3 HDAC1 / 2 complex . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| The mammalian SIN 3 complex consists of histone deacetylases ( HDAC 1 , HDAC 2 ) , several known proteins ( SAP 30 , N CoR ) and as yet unidentified proteins . ^^^ We have shown that TIS 7 protein interacts with several proteins of the SIN 3 complex ( mSin3B , HDAC 1 , N CoR and SAP 30 ) by yeast two hybrid screening and co immunoprecipitations . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| HDAC 9 interacts and co localizes in vivo with a number of transcriptional repressors and co repressors , including TEL and N CoR , whose functions have been implicated in the pathogenesis of hematological malignancies . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptor corepressors SMRT ( silencing mediator of retinoid and thyroid receptors ) and N CoR ( nuclear receptor corepressor ) recruit histone deacetylase ( HDAC ) activity to targeted regions of chromatin . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| Unliganded thyroid hormone receptor ( TR ) actively represses transcription via the nuclear receptor corepressor ( N CoR ) / histone deacetylase 3 ( HDAC 3 ) complex . ^^^ N CoR and HDAC 3 are both required for recruitment of SNF2H to the repressed gene . ^^^ |
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| Interacting proteins: Q9UKV0 and O75376 |
Pubmed |
SVM Score :0.0 |
| HDAC 4 , HDAC 5 , and HDAC 7 function as transcriptional corepressors that interact with the MEF 2 transcription factors and the N CoR , BCoR , and CtBP corepressors . ^^^ |
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